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https://www.readbyqxmd.com/read/28550709/effect-of-renal-function-status-on-the-prognostic-value-of-heart-rate-in-acute-ischemic-stroke-patients
#1
Zhengbao Zhu, Chongke Zhong, Tian Xu, Aili Wang, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Qingjuan Du, Yongqiu Li, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND AND AIMS: The association between heart rate and prognosis of ischemic stroke remains debatable, and whether renal function status influences the relationship between them is still not elucidated. METHODS: A total of 3923 ischemic stroke patients were included in this prospective multicenter study from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after stroke...
May 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28550648/pregnancy-outcome-in-more-than-5000-births-to-women-with-viral-hepatitis-a-population-based-cohort-study-in-sweden
#2
Knut Stokkeland, Jonas Filip Ludvigsson, Rolf Hultcrantz, Anders Ekbom, Jonas Höijer, Matteo Bottai, Olof Stephansson
Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28550494/cost-effectiveness-of-combined-serum-anti-helicobacter-pylori-igg-antibody-and-serum-pepsinogen-concentrations-for-screening-for-gastric-cancer-risk-in-japan
#3
Shota Saito, Motoi Azumi, Yusuke Muneoka, Katsuhiko Nishino, Takashi Ishikawa, Yuichi Sato, Shuji Terai, Kouhei Akazawa
BACKGROUND: A combination of assays for the presence of serum anti-Helicobacter pylori IgG antibody (HPA) and serum pepsinogen (PG) concentrations can be used to screen for gastric cancer risk. In Japan, this "ABC method" is considered an effective means of stratifying gastric cancer risk. This study aimed to ascertain its cost-effectiveness for assessing gastric cancer risk. METHODS: A Markov model was constructed to compare the cost-effectiveness of two strategies for gastric cancer-risk screening over a 30-year period: the ABC method, which uses a combination of assessing the presence of HPA and measuring serum PG concentrations and scheduling endoscopies accordingly, and annual endoscopic screening...
May 26, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28550491/influence-of-diet-on-the-course-of-inflammatory-bowel-disease
#4
Laura Tasson, Cristina Canova, Maria Grazia Vettorato, Edoardo Savarino, Renzo Zanotti
BACKGROUND: While the importance of diet in the pathogenesis of inflammatory bowel disease (IBD) is generally recognized, influence of food on the course of IBD is little understood. AIM: The purpose of this study was to assess the association between food intake and course of disease in patients with IBD. METHODS: We performed a cross-sectional study on 103 adult patients (50 with active disease and 53 in remission, divided by their calprotectin level), who completed a food frequency questionnaire on their intake of several foods over 1 year...
May 26, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28550481/antiplatelet-pretreatment-and-outcomes-in-intravenous-thrombolysis-for-stroke-a-systematic-review-and-meta-analysis
#5
Georgios Tsivgoulis, Aristeidis H Katsanos, Ramin Zand, Vijay K Sharma, Martin Köhrmann, Sotirios Giannopoulos, Efthymios Dardiotis, Anne W Alexandrov, Panayiotis D Mitsias, Peter D Schellinger, Andrei V Alexandrov
Since there are contradictory data regarding the association of antiplatelet pretreatment (AP) with safety and efficacy outcomes of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), we conducted a systematic review and meta-analysis of available randomized-controlled clinical trials (RCTs) to investigate the association of AP with outcomes of AIS patients treated with intravenous alteplase. The outcome events of interest included symptomatic intracranial hemorrhage (sICH), fatal ICH, complete recanalization (CR), 3-month favorable functional outcome (FFO, mRS score 0-1), 3-month functional independence (FI, mRS score 0-2), and mortality...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28550476/stroke-and-other-cardiovascular-events-in-patients-with-obstructive-sleep-apnea-and-the-effect-of-continuous-positive-airway-pressure
#6
Mirjam H Schipper, Korne Jellema, Bregje J W Thomassen, Diego Alvarez-Estevez, Johan Verbraecken, Roselyne M Rijsman
Obstructive sleep apnea (OSA) is a known-risk factor for cardiovascular diseases. There are indications that treatment with continuous positive airway pressure (CPAP) reduces the risk of new cardiovascular events. In this study, we analyzed the incidence of cardiovascular events in patients with OSA and compared for the impact of CPAP therapy. All polysomnographies performed in 2009 and 2010 were selected with an AHI ≥5 and patients older than 18 years. These 1110 patients were approached with a questionnaire about cardiovascular events and CPAP treatment...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28550456/what-doesn-t-work-for-whom-exploring-heterogeneity-in-responsiveness-to-the-family-check-up-in-early-childhood-using-a-mixture-model-approach
#7
William E Pelham, Thomas J Dishion, Jenn-Yun Tein, Daniel S Shaw, Melvin N Wilson
This study applied latent class analysis to a family-centered prevention trial in early childhood to identify subgroups of families with differential responsiveness to the Family Check-Up (FCU) intervention. The sample included 731 families with 2-year-olds randomized to the FCU or control condition and followed through age 5 with yearly follow-up assessments. A two-step mixture model was used to examine whether specific constellations of family characteristics at age 2 (baseline) were related to intervention response across ages 3, 4, and 5...
May 27, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28550446/short-stay-vs-long-stay-postpartum-psychiatric-admissions-a-population-based-study
#8
Inbal Shlomi-Polachek, Kinwah Fung, Samantha Meltzer-Brody, Simone N Vigod
About 1-2/1000 of postpartum women require psychiatric admission. Length of stay is variable, and little is known about short postpartum admission. From all women in Ontario, Canada, with a psychiatric admission within 1 year postpartum (2007-2012) (n = 1702), we compared women with admissions <72 h to women with longer admissions on sociodemographics, clinical characteristics and post-discharge mental health service use. About 37% of admissions were <72 h. These women were more likely to be adolescents (11...
May 26, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28550378/longitudinal-modeling-of-depressive-trajectories-among-hiv-infected-men-using-cocaine
#9
Shibani Mukerji, Roxanna Haghighat, Vikas Misra, David R Lorenz, Alex Holman, Anupriya Dutta, Dana Gabuzda
Cocaine use is prevalent among HIV-infected individuals. While cross-sectional studies suggest that cocaine users may be at increased risk for depression, long-term effects of cocaine on depressive symptoms remain unclear. This is a longitudinal study of 341 HIV-infected and uninfected men (135 cocaine users and 206 controls) ages 30-60 enrolled in the Multicenter AIDS Cohort Study during 1996-2009. The median baseline age was 41; 73% were African-American. In mixed-effects models over a median of 4.8 years of observation, cocaine use was associated with higher depressive symptoms independent of age, education level, and smoking (n = 288; p = 0...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550093/causal-effect-of-plasminogen-activator-inhibitor-type-1-on-coronary-heart-disease
#10
REVIEW
Ci Song, Stephen Burgess, John D Eicher, Christopher J O'Donnell, Andrew D Johnson
BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. METHODS AND RESULTS: To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies...
May 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28550072/plasma-%C3%AE-synuclein-predicts-cognitive-decline-in-parkinson-s-disease
#11
Chin-Hsien Lin, Shieh-Yueh Yang, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu, Ming-Jang Chiu
OBJECTIVE: α-Synuclein is critical to the pathogenesis of Parkinson's disease (PD). Few studies examined the plasma levels of α-synuclein due to the exceptionally low level of α-synuclein in plasma compared with cerebrospinal fluid. We aimed to investigate plasma α-synuclein in patients with PD of different disease severity. METHODS: There were total 114 participants, including 80 patients with PD and 34 controls, in the study. Participants received a complete evaluation of motor and non-motor symptoms, including cognitive function...
May 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28549956/serum-high-sensitive-c-reactive-protein-hscrp-level-and-crp-genetic-polymorphisms-are-associated-with-abdominal-aortic-aneurysm
#12
Zuo Shangwei, Wei Yingqi, Xiong Jiang, Wu Zhongyin, Juan Juan, Chen Dafang, Hu Yonghua, Guo Wei
BACKGROUND: Abdominal aortic aneurysm (AAA) development involves an inflammatory process with a potential genetic background. C-reactive protein (CRP) is an acute phase protein and was elevated in patients with AAA. The aim of this study was to investigate the association among serum high-sensitive CRP (hsCRP) concentration, its CRP genetic polymorphisms and AAA. METHODS: Serum hsCRP concentrations and abdominal aorta diameters were measured, correlation analysis between them were performed in 155 unrelated participants with AAA and 310 non-AAA controls...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549819/rivaroxaban-for-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-and-active-cancer
#13
Eva S Laube, Anthony Yu, Dipti Gupta, Yimei Miao, Patrick Samedy, Jonathan Wills, Stephen Harnicar, Gerald A Soff, Simon Mantha
Rivaroxaban is broadly used for the primary prevention of stroke and systemic embolism in the general population with nonvalvular atrial fibrillation (AF). However, there is little published evidence on the safety and efficacy of rivaroxaban for AF in patients with active cancer. The aim of this study was to assess the safety and efficacy of rivaroxaban in patients with active cancer and AF. The use of rivaroxaban in patients with cancer at the Memorial Sloan Kettering Cancer Center is monitored in the setting of a Quality Assessment Initiative...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28549758/prevalence-of-abdominal-obesity-and-its-association-with-cardio-metabolic-risk-factors-among-older-adults-in-ecuador
#14
Carlos H Orces, Martha Montalvan, Daniel Tettamanti
AIMS: To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador. MATERIALS AND METHODS: The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the association of abdominal obesity with cardio metabolic risk factors...
May 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28549705/association-of-grip-strength-with-risk-of-all-cause-mortality-cardiovascular-diseases-and-cancer-in-community-dwelling-populations-a-meta-analysis-of-prospective-cohort-studies
#15
Yili Wu, Weijing Wang, Tianwei Liu, Dongfeng Zhang
OBJECTIVES: Grip strength has been linked to risk of adverse health outcomes. This study aimed to quantitatively assess the associations between grip strength and risk of all-cause mortality, cardiovascular diseases, and cancer in community-dwelling populations. DESIGN: A meta-analysis of prospective cohort studies was conducted. SETTING: Embase, Medline, and PubMed were searched from inception to September 14, 2016. Study-specific most adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were combined with a random effects model...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549500/greater-preclinical-atherosclerosis-in-treated-monogenic-familial-hypercholesterolemia-vs-polygenic-hypercholesterolemia
#16
Mahtab Sharifi, Elizabeth Higginson, Sven Bos, Angela Gallivan, Darren Harvey, Ka Wah Li, Amali Abeysekera, Angela Haddon, Helen Ashby, Kate E Shipman, Jackie A Cooper, Marta Futema, Jeanine E Roeters van Lennep, Eric J G Sijbrands, Mourad Labib, Devaki Nair, Steve E Humphries
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes causing FH and are most likely to have a polygenic cause for their raised LDL-C. We assessed the degree of preclinical atherosclerosis in treated patients with monogenic FH versus polygenic hypercholesterolemia...
May 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28549465/early-feeding-and-risk-of-juvenile-idiopathic-arthritis-a-case-control-study-in-a-prospective-birth-cohort
#17
Erik Kindgren, Mats Fredrikson, Johnny Ludvigsson
BACKGROUND: Juvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA. METHODS: All parents with children born between October 1, 1997 and October 1, 1999 in Southeast Sweden were asked to participate in the ABIS prospective cohort study (All Babies in Southeast Sweden), At 1 year, questionnaires with information on breastfeeding and introduction of foods were completed by 10,565 families...
May 26, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28549429/sleep-characteristics-in-child-and-adolescent-offspring-of-parents-with-bipolar-disorder-a-case-control-study
#18
Antonin Sebela, Tomas Novak, David Kemlink, Michal Goetz
BACKGROUND: Impairment of sleep and circadian rhythm is a typical feature of bipolar disorder (BD). We carried out an exploratory cross-sectional case-control study to extend the knowledge of sleep characteristics in offspring at risk for BD. METHODS: We investigated 42 offspring of bipolar parents (OB) (mean age 12.5 ± 3.2) and 42 sex and age matched comparison offspring of healthy parents. We administered the Pediatric Sleep Questionnaire, the Morningness/Eveningness Questionnaire and The General Behavior Inventory Sleep Subscale (GBISS) to assess circadian preference, and to identify sleep impairment symptoms...
May 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28549428/rheumatoid-factors-do-not-predict-cardiovascular-disease-and-mortality-in-the-general-population-in-the-busselton-health-survey
#19
Johannes Nossent, Warren Raymond, Mark Divitini, Matthew Knuiman
BACKGROUND: Rheumatoid Factors (RF) are antibodies directed against the Fc portion of IgG and are involved in clearance of immune complexes. While RF can develop in a wide range of conditions, higher RF levels indicate a greater risk for a severe disease course in Rheumatoid Arthritis (RA) patients including cardiovascular complications and premature death. We investigated whether RF also constitute a risk factor for these outcomes in the general population. METHODS: We included 2,323 participants (46% male, mean age 50 years) free of CVD at baseline in 1972...
May 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28549302/partner-level-substance-use-associated-with-increased-sexual-risk-behaviors-among-men-who-have-sex-with-men-in-san-francisco-ca
#20
Robert E Brown, Caitlin Turner, Jaclyn Hern, Glenn-Milo Santos
BACKGROUND: Substance use is highly prevalent among men who have sex with men (MSM) and is associated with individual-level sexual risk behaviors. However, few studies have explored the relationship between substance use and HIV risk behaviors within partnerships. METHODS: We examined partner-level data between MSM participants (n=23) and their sexual partners (n=52). We used multivariable generalized estimating equations (GEE) logistic regression to assess the relationship between partner-level substance use during their last sexual encounter with each partner, and engaging in condomless anal intercourse (CAI) and serodiscordant CAI...
April 21, 2017: Drug and Alcohol Dependence
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