Marinela Contreras, Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Sara Artigas-Jerónimo, Almudena González-García, Nadezhda V Shilova, Nicolai V Bovin, Sandra Díaz-Sánchez, Elisa Ferreras-Colino, Iván Pacheco, Jindřich Chmelař, Petr Kopáček, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente
BACKGROUND: Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without α-Gal modifications involved in modulating human immune response against this carbohydrate...
July 19, 2023: Parasites & Vectors