keyword
https://read.qxmd.com/read/37985065/enzymatically-derived-oligo-carrageenans-interact-with-%C3%AE-gal-antibodies-and-galectin-3
#21
JOURNAL ARTICLE
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Carrageenans are linear sulfated galactans synthesized in the Gigartinales, Rhodophyceae species with a varied range of biological properties that are of value to the pharmaceutical and cosmetic sectors. It is unknown how the fine structure of carrageenans dictates their capacity to affect molecular and cellular responses important to wound healing, or the ability to mitigate oxidative, hemostatic and inflammatory processes. Here we use specific endo-carrageenases, from the marine bacterium Zobellia galactanivorans, to produce enzymatically defined neo-series oligosaccharides from carrageenans with 3,6-anhydro-D-galactose on the non-reducing end...
January 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/37943208/ige-to-common-food-allergens-is-associated-with-cardiovascular-mortality-in-the-national-health-and-examination-survey-and-the-multi-ethnic-study-of-atherosclerosis
#22
JOURNAL ARTICLE
Corinne Keet, Emily C McGowan, David Jacobs, Wendy S Post, Nathan E Richards, Lisa J Workman, Thomas A E Platts-Mills, Ani Manichaikul, Jeffrey M Wilson
BACKGROUND: In individuals without symptomatic food allergy, food-specific IgE is considered clinically irrelevant. However, recent studies have suggested that galactose-α-1,3-galactose (alpha-gal) IgE is associated with cardiovascular (CV) disease. OBJECTIVE: We sought to determine whether sensitization to common food allergens is associated with CV mortality. METHODS: The association between IgE sensitization to foods and CV mortality ascertained to 2019 was examined in the National Health and Examination Survey (NHANES) 2005-2006 and the Wake Forest site of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort; MESA enrolled adults without baseline clinical CV diseases between 2000 and 2002...
February 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37936368/use-of-antithymocyte-globulin-rabbit-in-a-patient-with-known-alpha-gal-syndrome-undergoing-allogenic-stem-cell-transplantation
#23
JOURNAL ARTICLE
Hannah Peterson, Drew A Wells, Dennis Marjoncu, Kori Holman
INTRODUCTION: Alpha-gal syndrome (AGS) is a hypersensitivity disorder in which tick bites-most commonly from the lone star tick ( Ambylomma americanum )-trigger immunoglobulin E-mediated hypersensitivity reaction upon exposure to oligosaccharide galactosse-alpha-1,3-galactose (α-gal). α-gal is most notorious for being found in "red meat" products but is present in mammalian meats such as beef, pork, lamb, rabbit, and others. Manifestations of AGS hypersensitivity are variable...
November 7, 2023: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/37922649/multi-omics-analysis-of-zebrafish-response-to-tick-saliva-reveals-biological-processes-associated-with-alpha-gal-syndrome
#24
JOURNAL ARTICLE
Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Marinela Contreras, Sara Artigas-Jerónimo, Almudena González-García, Christian Gortázar, José de la Fuente
The alpha-Gal syndrome (AGS) is a tick-borne allergy. A multi-omics approach was used to determine the effect of tick saliva and mammalian meat consumption on zebrafish gut transcriptome and proteome. Bioinformatics analysis using R software was focused on significant biological and metabolic pathway changes associated with AGS. Ortholog mapping identified highly concordant human ortholog genes for the detection of disease-enriched pathways. Tick saliva treatment increased zebrafish mortality, incidence of hemorrhagic type allergic reactions and changes in behavior and feeding patterns...
December 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37918651/alpha-gal-ige-prevalence-patterns-in-the-united-states-an-investigation-of-3000-military-recruits
#25
JOURNAL ARTICLE
Samuel M Ailsworth, Apryl Susi, Lisa J Workman, Yun-Seong Ji, Jaimin Patel, Michael R Nelson, Thomas A E Platts-Mills, Cade M Nylund, Jeffrey M Wilson
BACKGROUND: IgE to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) is an important cause of allergic reactions to mammalian meat. The "alpha-gal syndrome" (AGS) is strongly associated with preceding history of tick bites and in the US is most commonly reported in parts of the southeast, but there has been limited investigation into national alpha-gal sensitization patterns and the relevance of other risk factors. OBJECTIVE: Systematically investigate alpha-gal IgE prevalence, regional patterns and risk factors...
October 31, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/37901762/unique-allergen-specific-human-ige-monoclonal-antibodies-derived-from-patients-with-allergic-disease
#26
JOURNAL ARTICLE
Bryan R E Smith, Kristina Reid Black, Max Bermingham, Sayeh Agah, Jill Glesner, Serge A Versteeg, Ronald van Ree, Glorismer Pena-Amelunxen, Lorenz Aglas, Scott A Smith, Anna Pomés, Martin D Chapman
INTRODUCTION: Allergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies in a human serum. Here, we report the production of unique human IgE monoclonal antibodies to major inhaled allergens and food allergens that can be produced at scale in perpetuity. MATERIALS AND METHODS: The IgE antibodies were derived from peripheral blood mononuclear cells of symptomatic allergic patients, mostly children aged 3-18 years, using hybridoma fusion technology...
2023: Front Allergy
https://read.qxmd.com/read/37838514/tick-salivary-glycans-a-sugar-coated-tick-bite
#27
REVIEW
Shahid Karim, Juan Manuel Leyva-Castillo, Sukanya Narasimhan
Ticks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain tick species...
October 12, 2023: Trends in Parasitology
https://read.qxmd.com/read/37831041/alpha-gal-syndrome-a-novel-and-increasingly-common-cause-of-anaphylaxis
#28
REVIEW
Jonathan A Edlow
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency over time. It is related to Lone Star tick bites in the United States and occurs in many other parts of the world. It is especially common in the southeastern United States. In addition to the usual symptoms of anaphylaxis, gastrointestinal symptoms are prominent. Another unusual feature is the delay of several hours between eating meat and the development of symptoms. Diagnosis can be made by a blood test for the immunoglobulin E antibodies to a specific oligosaccharide...
October 11, 2023: Annals of Emergency Medicine
https://read.qxmd.com/read/37774431/c-376a-g-p-ser126gly-alpha-galactosidase-a-mutation-induces-er-stress-unfolded-protein-response-and-reduced-enzyme-trafficking-to-lysosome-possible-relevance-in-the-pathogenesis-of-late-onset-forms-of-fabry-disease
#29
JOURNAL ARTICLE
Concetta Riillo, Giuseppe Bonapace, Maria Teresa Moricca, Simona Sestito, Alessandro Salatino, Daniela Concolino
Fabry Disease (FD) (OMIM 301500) is a metabolic X-linked inherited lysosomal storage disorder that results from the deficient activity of Alpha-Galactosidase A (Alpha-Gal), a lysosomal hydrolase that cleaves neutral glycosphingolipids with terminal N-linked galactosyl moieties, mainly globotriaosylceramides (Gb3). The enzyme, encoded by a 12-kb gene mapping on the long arm (Xq22.1 region) of the X chromosome, is constituted by a glycosylated subunit of approximately 55 kD, synthesized as an inactive precursor that undergoes maturation in endoplasmic reticulum (ER) and Golgi apparatus before being delivered to the lysosome to form a functional dimer...
September 14, 2023: Molecular Genetics and Metabolism
https://read.qxmd.com/read/37740636/delayed-anaphylaxis-due-to-alpha-gal-allergy-a-modified-desensitization-protocol-with-red-meat-in-an-adult-patient
#30
JOURNAL ARTICLE
Fatma Merve Tepetam, Zeynep Yegin Katran, Ravza Bayraktar Barın, Betül Çakmak Uğurlu
Alpha-gal allergy is the sensitization to Alpha-gal present in saliva when a tick bites and the development of an IgE-mediated reaction to Alpha-gal also present in red meat by cross-reactivity. In contrast to other food allergies, symptoms occur as late as 2-6 hours after a meal. Prick to prick testing with nonmammalian meat in combination with cooked mammalian meat is recommended for diagnosis. However, the main diagnostic test is Alpha-gal sIgE> 0.1 IU/mL. The primary recommendation in patients with Alpha-gal syndrome is to prevent new tick bites and avoid all mammalian meats...
September 2023: Tüberküloz Ve Toraks
https://read.qxmd.com/read/37705677/high-risk-groups-for-alpha-gal-sensitization
#31
JOURNAL ARTICLE
Marie Benders-Guedj, Martin Köberle, Heidelore Hofmann, Tilo Biedermann, Ulf Darsow
BACKGROUND: Tick bite-induced IgE-mediated reactions to the oligosaccharide galactose α-1,3-galactose (alpha-gal) are increasingly recognized. This study investigated alpha-gal sensitization in three groups with different tick bite exposure. MATERIALS AND METHODS: Specific IgE antibodies to alpha-gal and total IgE were investigated in 485 patients with Lyme borreliosis with different disease manifestations and compared to a control group of 200 randomly selected patients without increased exposure to tick bites...
2023: Allergologie Select
https://read.qxmd.com/read/37689672/treatment-of-idiopathic-anaphylaxis-with-dupilumab-a-case-report
#32
JOURNAL ARTICLE
Elizabeth Pepper, Luke Pittman
BACKGROUND: Anaphylaxis is an acute, potentially life-threatening allergic reaction that typically occurs after exposure to a trigger, while idiopathic anaphylaxis (IA) occurs in the absence of a trigger. Acute management of both triggered anaphylaxis and IA relies on the use of epinephrine. In some patients with recurrent IA, glucocorticoid prophylaxis with prednisone can be effective. While there is currently no high quality evidence for the use of other prophylactic options to prevent recurrent IA, evolving data exists to support the consideration of biologics that target IgE or the Th2 pathway...
September 9, 2023: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/37642435/an-outbreak-of-anaphylactic-transfusion-reactions-to-group-b-plasma-and-platelets-and-its-possible-relationship-to-alpha-gal-syndrome
#33
Colleen W Gilstad, Kathleen Conry-Cantilena, Roya Zarpak, Anne F Eder
BACKGROUND: Alpha-gal syndrome (AGS) is a potentially life-threatening acquired meat allergy associated with tick bites. The allergen Galactose-α-1,3-Galactose is antigenically similar to the B blood group antigen. B blood group status offers some protection against development of the allergy. Although not preferred practice, transfusion of plasma and platelets from group B donors is believed to be safe for group O recipients. STUDY DESIGN AND METHODS: Anaphylactic transfusion reactions were reported for three patients in two Washington DC hospitals from Nov 2022 to February 2023...
October 2023: Transfusion
https://read.qxmd.com/read/37636877/alpha-gal-syndrome-food-or-drug-allergy-a-case-report
#34
Marina Božan, Vesna Vukičević Lazarević, Ivan Marković, Jadranka Morović-Vergles, Joško Mitrović
Alpha-gal syndrome is an immunoglobulin E-mediated hypersensitivity characterized by delayed allergic reactions to ingested products containing alpha-gal carbohydrate. We present a patient with recurrent urticaria and suspected repaglinide hypersensitivity, who was eventually diagnosed with alpha-gal syndrome, wanting to emphasize possible drug allergy misdiagnosis and required caution with the medication choice.
September 2023: Clinical Case Reports
https://read.qxmd.com/read/37600621/delayed-hypersensitivity-reaction-to-infliximab-due-to-mammalian-meat-allergy
#35
Esthermari González Polanco, Stephen Borowitz
Mammalian meat allergy is a delayed immunoglobulin E (IgE) mediated hypersensitivity reaction to galactose-alpha-1,3-galactose (alpha-gal). Alpha-gal is an oligosaccharide present on glycoproteins and glycolipids of nonprimate mammals as well as biologic agents prepared using mammalian cells including infliximab. We describe a pediatric patient with Crohn's disease who developed urticaria and pruritus roughly 6 hours after her very first infliximab infusion that progressed to chronic urticaria following subsequent infliximab infusions...
August 2023: JPGN reports
https://read.qxmd.com/read/37545316/oral-immunotherapy-in-alpha-gal-red-meat-allergy-could-specific-ige-be-a-potential-biomarker-in-monitoring-management
#36
JOURNAL ARTICLE
D Ünal, D Eyice-Karabacak, A Kutlu, S Demir, C Tüzer, A F Arslan, S R Işık, A Gelincik
BACKGROUND: Oral immunotherapy (OIT) is a promising treatment for food allergies. Our aim was to establish the long-term safety and efficacy of a novel red meat (RM) OIT in galactose-alpha-1,3-galactose (alpha-gal) allergy in adults. METHODS: Out of 20 patients with confirmed RM allergy, five (41.66%) underwent an early OIT, seven (58.33%) underwent a delayed protocol and eight patients who were not desensitized formed the patient control group. 15 and 27 day RM OIT for early-onset and delayed-onset alpha-gal allergy were administered, respectively...
August 7, 2023: Allergy
https://read.qxmd.com/read/37512948/alpha-gal-bound-aptamer-and-vancomycin-synergistically-reduce-staphylococcus-aureus-infection-in-vivo
#37
JOURNAL ARTICLE
Matthew K Doherty, Claire Shaw, Leslie Woods, Bart C Weimer
Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive and persistent threat that requires the development of novel therapies or adjuvants for existing ones. Aptamers, small single-stranded oligonucleotides that form 3D structures and can bind to target molecules, provide one possible therapeutic route, especially when presented in combination with current antibiotic applications. BALB/c α-1, 3-galactosyltransferase (-/-) knockout (GTKO) mice were infected with MRSA via tail vein IV and subsequently treated with the αSA31 aptamer (n = 4), vancomycin (n = 12), or αSA31 plus vancomycin (n = 12), with split doses in the morning and evening...
July 8, 2023: Microorganisms
https://read.qxmd.com/read/37498792/health-care-provider-knowledge-regarding-alpha-gal-syndrome-united-states-march-may-2022
#38
JOURNAL ARTICLE
Ann Carpenter, Naomi A Drexler, David W McCormick, Julie M Thompson, Gilbert Kersh, Scott P Commins, Johanna S Salzer
Alpha-gal syndrome (AGS) is an emerging, tick bite-associated immunoglobulin E-mediated allergic condition characterized by a reaction to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is found in mammalian meat and products derived from mammals, including milk, other dairy products, and some pharmaceutical products. Symptoms range from mild (e.g., a rash or gastrointestinal upset) to severe (anaphylaxis); onset typically occurs ≥2 hours after exposure to alpha-gal. No treatment or cure is currently available...
July 28, 2023: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/37498787/geographic-distribution-of-suspected-alpha-gal-syndrome-cases-united-states-january-2017-december-2022
#39
JOURNAL ARTICLE
Julie M Thompson, Ann Carpenter, Gilbert J Kersh, Tyler Wachs, Scott P Commins, Johanna S Salzer
Alpha-gal syndrome (AGS) is an emerging, tick bite-associated allergic condition characterized by a potentially life-threatening immunoglobulin E (IgE)-mediated hypersensitivity to galactose-alpha-1,3-galactose (alpha-gal), an oligosaccharide found in most nonprimate mammalian meat and products derived from these mammals. Specific symptoms and severity of AGS vary among persons, and no treatment or cure is currently available. During 2010-2018, more than 34,000 suspected cases of AGS were identified in the United States, but current knowledge of where cases occur is limited...
July 28, 2023: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/37468955/allergic-reactions-to-tick-saliva-components-in-zebrafish-model
#40
JOURNAL ARTICLE
Marinela Contreras, Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Sara Artigas-Jerónimo, Almudena González-García, Nadezhda V Shilova, Nicolai V Bovin, Sandra Díaz-Sánchez, Elisa Ferreras-Colino, Iván Pacheco, Jindřich Chmelař, Petr Kopáček, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente
BACKGROUND: Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without α-Gal modifications involved in modulating human immune response against this carbohydrate...
July 19, 2023: Parasites & Vectors
keyword
keyword
37426
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.