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GDF-15

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https://www.readbyqxmd.com/read/28891811/nf-%C3%AE%C2%BAb-regulates-gdf-15-to-suppress-macrophage-surveillance-during-early-tumor-development
#1
Nivedita M Ratnam, Jennifer M Peterson, Erin E Talbert, Katherine J Ladner, Priyani V Rajasekera, Carl R Schmidt, Mary E Dillhoff, Benjamin J Swanson, Ericka Haverick, Raleigh D Kladney, Terence M Williams, Gustavo W Leone, David J Wang, Denis C Guttridge
Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms underlying their self-protection remain unclear. Here, we report that this dynamic interaction between tumor cells and macrophages is integrally linked by a soluble factor identified as growth and differentiation factor 15 (GDF-15). In vitro, tumor-derived GDF-15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide (NO) production...
September 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28872977/growth-differentiation-factor-15-gdf-15-level-and-relation-to-clinical-manifestations-in-egyptian-systemic-sclerosis-patients-preliminary-data
#2
Sherif M Gamal, Fatema T Elgengehy, Asmaa Kamal, Samah A El Bakry, Elham Shabaan, Aliaa Elgendy, Iman H Bassyouni
AIM OF THE WORK: This study aims to assess Growth differentiation factor-15 (GDF-15) level in Scleroderma patients and its relation to disease manifestations. PATIENTS AND METHODS: This study included 55 scleroderma patients and 40 age and sex matched healthy volunteers. All patients were subjected to full history taking, thorough clinical examination, and laboratory investigations. GDF-15 serum levels were analyzed in patients and controls using human GDF-15 immunoassay Quantikine ELISA kit...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28869715/growth-differentiation-factor-15-as-a-predictor-of-adverse-renal-outcomes-in-patients-with-immunoglobulin-a-nephropathy
#3
Ki Ryang Na, Yoo Hyung Kim, Hyo Kyun Chung, Min-Kyung Yeo, Young Rok Ham, Jin Young Jeong, Koon Soon Kim, Kang Wook Lee, Dae Eun Choi
BACKGROUND: Growth differentiation factor 15 (GDF 15) has recently been reported as a useful prognostic marker in patients with chronic inflammatory disease and heart disease. AIM: Our aim of this study is evaluating the role of GDF 15 as a potential predictor of renal outcome in immunoglobulin A nephropathy (IgAN). METHODS: 212 patients in the Chungnam National Hospital glomerulonephritis cohort, who were diagnosed as biopsy-proven IgAN from March 2010 to June 2014, were included...
September 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28819713/plasma-growth-differentiation-factor-15-is-a-potential-biomarker-for-pediatric-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease
#4
Gang Li, Yan Li, Xiao-Qiu Tan, Peng Jia, Jian Zhao, Dong Liu, Ting Wang, Bin Liu
We aimed to investigate plasma growth differentiation factor-15 (GDF-15) levels in pediatric pulmonary arterial hypertension secondary to congenital heart disease (PAH-CHD), and assess the association with hemodynamic parameters. Plasma GDF-15 levels were measured in children with PAH-CHD (n = 46) and compared to children with CHD without PAH (n = 39). Normal individuals (n = 30) served as health control group. Plasma GDF-15 levels were significantly elevated in patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, interquartile range [IQR] 926...
August 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28815568/gliptin-therapy-reduces-hepatic-and-myocardial-fat-in-type-2-diabetic-patients-gliptins-and-cardiometabolic-risk
#5
Lana Kosi-Trebotic, Jürgen Harreiter, Marek Chmelik, Anita Thomas, Ivica Just-Kukurova, Siegfried Trattnig, Alexandra Kautzky-Willer
AIMS: Increased hepatic and cardiac fat are common in patients with Type 2 diabetes mellitus (T2DM) and associated with greater risk of liver fibrosis and cardiovascular (CV) events. Sex-specific differences of Dipeptidyl peptidase-four (DPP-4) inhibitor effects on hepatic (HCL) and myocardial fat content (MYCL) have not been evaluated yet. METHODS: 41 T2DM patients received a gliptin add-on therapy when not reaching HbA1c goals under metformin monotherapy. They underwent cardiac and liver magnetic resonance tomography and spectroscopy before and 6 months after therapy initiation...
August 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28814234/biomarkers-of-cardiovascular-risk-in-haemodialysis-patients
#6
Beata Franczyk, Anna Gluba-Brzózka, Jacek Rysz
BACKGROUND: All stages of chronic kidney disease (CKD) are associated with increased risks of atherosclerosis and cardiovascular morbidity and mortality. According to studies, levels of copeptin, growth differentiation factor-15 (GDF-15) and heart fatty-acid binding protein (h-FABP) are increased in dialysis patients. MATERIALS: This study included 50 patients (19 women, 31 men) chronically undergoing haemodialysis. The concentration of markers: copeptin, GDF-15, h-FABP, troponin and serum creatine kinase MB (CKMB) were measured with the use of ELISA tests...
August 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28771550/gdf-15-predicts-cardiovascular-events-in-acute-chest-pain-patients
#7
Stergios Tzikas, Lars Palapies, Constantinos Bakogiannis, Tanja Zeller, Christoph Sinning, Stephan Baldus, Christoph Bickel, Vassilios Vassilikos, Karl J Lackner, Andreas Zeiher, Thomas Münzel, Stefan Blankenberg, Till Keller
BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI. METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI...
2017: PloS One
https://www.readbyqxmd.com/read/28762934/-diagnostic-value-of-biochemical-markers-in-patients-with-chronic-heart-failure-with-reduced-borderline-and-preserved-left-ventricular-ejection-fraction
#8
E V Bazaeva, R P Myasnikov, V A Metelskaya, S A Boytsov
PURPOSE OF THE STUDY: The study of the diagnostic value of biochemical markers of myocardial stress and inflammation in chronic heart failure (CHF) with different values of the ejection fraction (EF) of the left ventricle (LV). MATERIAL AND METHODS: The cross-sectional study included 105 patients aged 24 to 84 years (mean 58+/-14 years) with stable chronic heart failure I-II NYHA functional class classification. The causes of CHF were ischemic heart disease (IHD) in 33% of patients and arterial hypertension (AH) - 67%...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28762762/gdf-15-and-trail-r2-are-powerful-predictors-of-long-term-mortality-in-patients-with-acute-myocardial-infarction
#9
Emma Skau, Egil Henriksen, Philippe Wagner, Pär Hedberg, Agneta Siegbahn, Jerzy Leppert
Background The Proximity Extension Assay proteomics chip provides a large-scale analysis of 92 biomarkers linked to cardiovascular disease or inflammation. We aimed to identify the biomarkers that best predicted long-term all-cause mortality in patients with acute myocardial infarction. Methods In this prospective cohort study, 92 biomarkers were analysed in 847 consecutive patients from the Västmanland Myocardial Infarction Study with a median follow-up of 6.9 years. Results The mean (± standard deviation) age of the patients was 70 (11...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28760218/growth-differentiation-factor-15-and-risk-of-major-bleeding-in-atrial-fibrillation-insights-from-the-randomized-evaluation-of-long-term-anticoagulation-therapy-re-ly-trial
#10
RANDOMIZED CONTROLLED TRIAL
Ziad Hijazi, Jonas Oldgren, Ulrika Andersson, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Paul A Reilly, Salim Yusuf, Agneta Siegbahn, Lars Wallentin
OBJECTIVE: To evaluate and validate the prognostic value of growth-differentiation factor 15 (GDF-15) beyond clinical characteristics and other biomarkers concerning bleeding and stroke outcomes in patients with atrial fibrillation in the RE-LY trial. METHODS: GDF-15 was measured in samples collected at randomization in 8,474 patients with a median follow-up time of 1.9 years. Patients were stratified based on predefined GDF-15 cutoffs: group 1, <1,200 ng/L (the 90th percentile in healthy individuals); group 2, 1,200-1,800; and group 3, >1,800 ng/L (high-risk individuals)...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28734463/usefulness-of-elevated-levels-of-growth-differentiation-factor-15-to-classify-patients-with-acute-coronary-syndrome-having-percutaneous-coronary-intervention-who-would-benefit-from-high-dose-statin-therapy
#11
Ioannis Tentzeris, Serdar Farhan, Matthias Karl Freynhofer, Miklos Rohla, Rudolf Jarai, Birgit Vogel, Sabina Baumgartner-Parzer, Michael Nürnberg, Alexander Geppert, Emil Wessely, Johann Wojta, Kurt Huber, Alexandra Kautzky-Willer
The aim of this study was to evaluate whether growth differentiation factor-15 (GDF-15) plasma concentration at the time of percutaneous coronary intervention (PCI) might help identify those patients with acute coronary syndrome (ACS), who benefit most from high-dose statin treatment. Two hundred eighty-four consecutive patients, who underwent percutaneous coronary intervention (PCI) for ACS, were included in a prospective registry. The combined end point at 3 months after PCI consisted of cardiovascular death, nonfatal myocardial infarction, and unstable angina...
September 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28721832/biomarkers-associated-with-bleeding-risk-in-the-setting-of-atrial-fibrillation
#12
Skevos Sideris, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Konstantinos Tsioufis, Dimitris Tousoulis
Background Prevention of thromboembolic disease, mainly stroke, with oral anticoagulants remains a major therapeutic goal in patients with atrial fibrillation. Unfortunately, despite the high efficacy, anticoagulant therapy is associated with a significant risk of, frequently catastrophic, hemorrhagic complications. Among different clinical and laboratory parameters related to an increased risk of bleeding, several biological markers have been recognized and various risk scores for bleeding have been developed...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28700471/plasma-cytokines-can-help-to-identify-the-development-of-severe-acute-pancreatitis-on-admission
#13
Li-Hui Deng, Cheng Hu, Wen-Hao Cai, Wei-Wei Chen, Xiao-Xin Zhang, Na Shi, Wei Huang, Yun Ma, Tao Jin, Zi-Qi Lin, Kun Jiang, Jia Guo, Xiao-Nan Yang, Qing Xia
Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicytokine array, were submitted to quantitative determination using either microparticle-based multiplex immunoassays analyzed on a Luminex 100 platform or enzyme-linked immunosorbent assay kits...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28683166/multibiomarker-analysis-in-patients-with-acute-myocardial-infarction
#14
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, Paul Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analysed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n = 61; NSTEMI, n = 57) compared to controls with excluded coronary artery disease (n = 76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28667186/analytically-sensitive-protein-detection-in-microtiter-plates-by-proximity-ligation-with-rolling-circle-amplification
#15
COMPARATIVE STUDY
Tonge Ebai, Felipe Marques Souza de Oliveira, Liza Löf, Lotta Wik, Caroline Schweiger, Anders Larsson, Ulrich Keilholtz, Johannes Haybaeck, Ulf Landegren, Masood Kamali-Moghaddam
BACKGROUND: Detecting proteins at low concentrations in plasma is crucial for early diagnosis. Current techniques in clinical routine, such as sandwich ELISA, provide sensitive protein detection because of a dependence on target recognition by pairs of antibodies, but detection of still lower protein concentrations is often called for. Proximity ligation assay with rolling circle amplification (PLARCA) is a modified proximity ligation assay (PLA) for analytically specific and sensitive protein detection via binding of target proteins by 3 antibodies, and signal amplification via rolling circle amplification (RCA) in microtiter wells, easily adapted to instrumentation in use in hospitals...
September 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28664745/association-between-pentraxin-3-and-growth-differentiation-factor-15-in-adolescent-male-swimmers
#16
N Karakuyu, M Belviranli, N Okudan
BACKGROUND: The purpose of this study was to evaluate plasma pentraxin 3 (PTX3) and growth differentiation factor-15 (GDF-15) concentrations in adolescent male swimmers and compare any possible interactions with canonical biochemical parameters. METHODS: Twenty-six adolescent male swimmers and 29 gender- and age-matched sedentary controls participated in this study. Fasting blood samples were taken from the participants. Biochemical values and plasma PTX3 and GDF-15 levels were measured...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28644092/single-and-multiple-cardiovascular-biomarkers-in-subjects-without-a-previous-cardiovascular-event
#17
Manan Pareek, Deepak L Bhatt, Muthiah Vaduganathan, Tor Biering-Sørensen, Arman Qamar, Axel Cp Diederichsen, Jacob Eifer Møller, Peter Hindersson, Margrét Leósdóttir, Martin Magnusson, Peter M Nilsson, Michael H Olsen
Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28641514/clinically-relevant-biomarkers-in-acute-heart-failure-an-update
#18
Agnibh Mukherji, Uzair Ansari, Martin Borggrefe, Ibrahim Akin, Michael Behnes
Acute heart failure (AHF) has been one of the fields, where owing to difficulties in diagnosis, prognostic stratification and management the associated morbidity and mortality remains unusually high. The advent of novel biomarkers apart from the traditional B-type natriuretic peptide and N-terminal proBNP involved in myocardial injury, neuro-hormonal activation, and ventricular remodeling augurs immense hope in redefining our approach towards AHF. METHODS: Biomarkers like midregional proatrial natriuretic peptide, soluble ST2, highly-sensitive troponin, and midregional proadrenomedullin are some such examples that have passed various stages of substantiation while there is an array of potential biomarkers in nascent stages like osteopontin, CTGF, GDF-15 and TGF beta-1 awaiting further reiteration...
June 22, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28635193/comparing-the-effect-of-cardiac-biomarkers-on-the-outcome-of-normotensive-patients-with-acute-pulmonary-embolism
#19
Yaser Jenab, Marzieh Pourjafari, Maryam Sotoudeh, Masoumeh Lotfi-Tokaldany, Nasrin Etesamifard, Shapour Shirani, Arash Jalali, Younes Nozari, Hamid-Reza Poorhosseini
Acute pulmonary embolism (PE) is a cardiovascular challenge with potentially fatal consequences. This study was designed to observe the association of novel cardiac biomarkers with outcome in this setting. In this prospective study, from 86 patients with a confirmed diagnosis of PE, 59 patients met the inclusion criteria (22 men, 37 women; mean age, 63.36±15.04 y).The plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), growth differentiation factor-15 (GDF-15), heart-type fatty acid-binding protein (H-FABP), tenascin-C, and D-dimer were measured at the time of confirmed diagnosis...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28612904/prognostic-value-of-growth-differentiation-factor-15-in-chinese-patients-with-heart-failure-a-prospective-observational-study
#20
Hua Wang, Qingyong Chen, Yingying Li, Xianchao Jing, Jiefu Yang
BACKGROUND: Growth differentiation factor-15 (GDF-15), a biomarker associated with remodeling, oxidative stress and inflammation, has been used to stratify heart failure (HF) patients. However, its prognostic value in Chinese HF patients is still unknown. METHODS: GDF-15 levels were examined on admission in 272 consecutive HF patients in Beijing Hospital (a Chinese tertiary medical center) by a commercial enzyme-linked immunosorbent assay. We recorded the incidence of all-cause mortality and/or readmission for HF during a median follow-up period of 558 days...
June 14, 2017: Cardiology Journal
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