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GDF-15

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https://www.readbyqxmd.com/read/29771963/predictive-value-of-long-term-changes-of-growth-differentiation-factor-15-over-a-27-year-period-for-heart-failure-and-death-due-to-coronary-heart-disease
#1
Nina Fluschnik, Francisco Ojeda, Tanja Zeller, Torben Jørgensen, Kari Kuulasmaa, Peter Moritz Becher, Christoph Sinning, Stefan Blankenberg, Dirk Westermann
BACKGROUND: Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. METHODS AND RESULTS: Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785)...
2018: PloS One
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#2
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29714603/growth-differentiation-factor-15-in-a-community-based-sample-age-dependent-reference-limits-and-prognostic-impact
#3
Steven Doerstling, Pär Hedberg, John Öhrvik, Jerzy Leppert, Egil Henriksen
BACKGROUND: Despite the growing body of evidence on growth differentiation factor 15 (GDF-15) reference values for patients with existing cardiovascular disease, limited investigation has been dedicated to characterizing the distribution and prognostic impact of GDF-15 in predominantly healthy populations. Furthermore, current cutoff values for GDF-15 fail to account for the well-documented age-dependence of circulating GDF-15. METHODS: From 810 community-dwelling older adults, we selected a group of apparently healthy participants (n = 268)...
May 1, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29698460/growth-differentiation-factor-15-and-fibroblast-growth-factor-23-are-associated-with-mortality-in-type-2-diabetes-an-observational-follow-up-study
#4
Marie Frimodt-Møller, Bernt Johan von Scholten, Henrik Reinhard, Peter Karl Jacobsen, Tine Willum Hansen, Frederik Ivar Persson, Hans-Henrik Parving, Peter Rossing
OBJECTIVES: Two biomarkers, growth differentiation factor 15 (GDF-15) and fibroblast growth factor 23 (FGF-23)), reflecting different aspects of renal pathophysiology, were evaluated as determinants of decline in estimated glomerular filtration rate (eGFR), incident cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D) and microalbuminuria, but without clinical cardiac disease. MATERIALS AND METHODS: Prospective study including 200 T2D patients...
2018: PloS One
https://www.readbyqxmd.com/read/29695834/contribution-of-three-dimensional-architecture-and-tumor-associated-fibroblasts-to-hepcidin-regulation-in-breast-cancer
#5
Nicole Blanchette-Farra, Daniel Kita, Anna Konstorum, Lia Tesfay, David Lemler, Poornima Hegde, Kevin P Claffey, Frank M Torti, Suzy V Torti
Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important role in controlling the growth of breast tumors. In patients with breast cancer, the combined expression of hepcidin and its membrane target, ferroportin, predict disease outcome. However, mechanisms that control hepcidin expression in breast cancer cells remain largely unknown. Here, we use three-dimensional breast cancer spheroids derived from cell lines and breast cancer patients to probe mechanisms of hepcidin regulation in breast cancer...
April 26, 2018: Oncogene
https://www.readbyqxmd.com/read/29682806/biomarkers-for-heart-failure-small-molecules-with-high-clinical-relevance
#6
REVIEW
C Magnussen, S Blankenberg
Heart failure (HF) is a rising epidemic due to the ageing population and progress in all areas of medicine. Thus, research efforts are made to ensure a timely diagnosis, to improve prognosis and treatment of the disease and to facilitate risk prediction at the population level. Because of their noninvasive determination with mostly high sensitivity and accuracy, circulating blood biomarkers are becoming increasingly important for daily clinical practice. Natriuretic peptides, especially B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and midregional pro-atrial natriuretic peptide (MR-proANP) and cardiac troponins are established blood biomarkers in HF diagnosis and prognosis of HF-related outcomes...
April 22, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29682097/growth-differentiation-factor-15-as-a-predictor-of-idiopathic-membranous-nephropathy-progression-a-retrospective-study
#7
Young Rok Ham, Chang Hun Song, Hong Jin Bae, Jin Young Jeong, Min-Kyung Yeo, Dae Eun Choi, Ki-Ryang Na, Kang Wook Lee
Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome. No biomarker to predict the long-term prognosis of IMN is currently available. Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor- β superfamily and has been associated with chronic inflammatory disease. It has the potential to be a useful prognostic marker in patients with renal diseases, such as diabetic nephropathy and IgA nephropathy. This study examined whether GDF-15 is associated with the clinical parameters in IMN and showed that GDF-15 can predict IMN disease progression...
2018: Disease Markers
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#8
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29652651/prediction-of-organ-involvement-in-systemic-sclerosis-by-serum-biomarkers-and-peripheral-endothelial-function
#9
Shin-Ya Kawashiri, Ayako Nishino, Takashi Igawa, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Akitomo Okada, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Munetoshi Nakashima, Akinari Mizokami, Naoki Matsuoka, Kiyoshi Migita, Fumihide Ogawa, Satoshi Ikeda, Koji Maemura, Hideki Nakamura, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami
OBJECTIVES: To identify prognostic factors among serum biomarkers and endothelial vasodilator function findings in patients with systemic sclerosis (SSc). METHODS: This is a clinical observational study. We assessed 60 consecutive SSc patients (44 limited cutaneous-type, 16 diffuse cutaneous-type). Circulating growth differentiation factor-15 (GDF-15), placenta growth factor (PlGF), endostatin, vascular endothelial growth factor (VEGF), and pentraxin 3 (PTX3) were measured by ELISA...
April 12, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#10
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29628937/a-meta-analysis-of-genome-wide-association-studies-of-growth-differentiation-factor-15-concentration-in-blood
#11
Jiyang Jiang, Anbupalam Thalamuthu, Jennifer E Ho, Anubha Mahajan, Weronica E Ek, David A Brown, Samuel N Breit, Thomas J Wang, Ulf Gyllensten, Ming-Huei Chen, Stefan Enroth, James L Januzzi, Lars Lind, Nicola J Armstrong, John B Kwok, Peter R Schofield, Wei Wen, Julian N Trollor, Åsa Johansson, Andrew P Morris, Ramachandran S Vasan, Perminder S Sachdev, Karen A Mather
Blood levels of growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), have been associated with various pathological processes and diseases, including cardiovascular disease and cancer. Prior studies suggest genetic factors play a role in regulating blood MIC-1/GDF-15 concentration. In the current study, we conducted the largest genome-wide association study (GWAS) to date using a sample of ∼5,400 community-based Caucasian participants, to determine the genetic variants associated with MIC-1/GDF-15 blood concentration...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29615435/association-of-biomarker-clusters-with-cardiac-phenotypes-and-mortality-in-patients-with-hiv-infection
#12
Rebecca Scherzer, Sanjiv J Shah, Eric Secemsky, Javed Butler, Carl Grunfeld, Michael G Shlipak, Priscilla Y Hsue
BACKGROUND: Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied. METHODS AND RESULTS: Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29607212/further-evidence-of-accelerated-aging-in-bipolar-disorder-focus-on-gdf-15
#13
Fang Yang, Izabela G Barbosa, Erica L Vieira, Moises E Bauer, Natalia P Rocha, Antonio L Teixeira
Background: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Methods: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study...
2018: Translational Neuroscience
https://www.readbyqxmd.com/read/29529072/growth-differentiation-factor-15-levels-and-the-risk-of-contrast-induced-acute-kidney-injury-in-acute-myocardial-infarction-patients-treated-invasively-a-propensity-score-match-analysis
#14
Ling Sun, Xuejun Zhou, Jianguang Jiang, Xuan Zang, Xin Chen, Haiyan Li, Haitao Cao, Qingjie Wang
BACKGROUND: Growth differentiation factor-15 (GDF-15) is an emerging biomarker for risk stratification in cardiovascular disease. Contrast-induced acute kidney injury (AKI) is an important complication in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). In this retrospectively observational study, we aimed to determine the role of GDF-15 and the risk of AKI in acute myocardial infarction (AMI) patients. METHODS: The medical records of 1195 patients with AMI were reviewed...
2018: PloS One
https://www.readbyqxmd.com/read/29512624/association-between-reverse-electrical-remodeling-and-cardiac-fibrosis-markers-in-patients-with-cardiac-resynchronization-therapy
#15
Hamza Sunman, Uğur Canpolat, Hikmet Yorgun, Adem Özkan, Muhammet Ulvi Yalçın, Tülin Bayrak, Levent Şahiner, Ergün Barış Kaya, Asuman Özkara, Kudret Aytemir, Ali Oto
OBJECTIVE: Cardiac resynchronization therapy (CRT) induces structural and electrical reverse remodeling of the failing heart. However, the association between native QRS narrowing and cardiac fibrosis markers has not been investigated in patients with an implanted CRT device. METHODS: A total of 41 symptomatic patients diagnosed with systolic heart failure who underwent CRT implantation were included in this study. Electrocardiogram findings and cardiac fibrosis marker levels [galectin-3, growth-differentiation factor-15 (GDF-15) and procollagen III N-terminal propeptide (P3TD)] were collected before and 12 months after initiation of biventricular pacing...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29489980/correlation-between-gdf-15-gene-polymorphism-and-the-formation-of-collateral-circulation-in-acute-st-elevation-myocardial-infarction
#16
Xiao-Ping Chen, Xiao-Sen Shang, Yan-Bin Wang, Zhi-Hua Fu, Yu Gao, Tao Feng
OBJECTIVE: To explore the correlation between growth differentiation factor 15 (GDF-15) -3148C/G polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction (STEMI) in Han population of Taiyuan area. METHOD: The present study included 92 STEMI patients and 56 normal controls based on coronary angiography; STEMI group was divided into collateral group and non-collateral group according to Rentrop's grading method. Polymerase chain reaction (PCR) and DNA sequencing methods were used to detect and analyze the GDF-15 -3148C/G polymorphism in all participants...
December 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29487139/proteomic-biomarkers-for-incident-aortic-stenosis-requiring-valvular-replacement
#17
Johan Ljungberg, Mikael Janiec, Ingvar A Bergdahl, Anders Holmgren, Johan Hultdin, Bengt Johansson, Ulf Näslund, Agneta Siegbahn, Tove Fall, Stefan Söderberg
Background -Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untreated AS is linked to high mortality. The aetiological background of AS is unknown. Previous human studies were typically based on case-control studies. Biomarkers identified in prospective studies could lead to novel mechanistic insights. Methods -Within a large population survey with blood samples obtained at baseline, 334 patients were identified that later underwent surgery for AS (median age (interquartile range) 59...
February 27, 2018: Circulation
https://www.readbyqxmd.com/read/29467963/new-extracellular-factors-in-glioblastoma-multiforme-development-neurotensin-growth-differentiation-factor-15-sphingosine-1-phosphate-and-cytomegalovirus-infection
#18
REVIEW
Jan Korbecki, Izabela Gutowska, Ireneusz Kojder, Dariusz Jeżewski, Marta Goschorska, Agnieszka Łukomska, Anna Lubkowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Recent years have seen considerable progress in understanding the biochemistry of cancer. For example, more significance is now assigned to the tumor microenvironment, especially with regard to intercellular signaling in the tumor niche which depends on many factors secreted by tumor cells. In addition, great progress has been made in understanding the influence of factors such as neurotensin, growth differentiation factor-15 (GDF-15), sphingosine-1-phosphate (S1P), and infection with cytomegalovirus (CMV) on the 'hallmarks of cancer' in glioblastoma multiforme...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29419569/brief-report-statin-effects-on-myocardial-fibrosis-markers-in-people-living-with-hiv
#19
Christopher deFilippi, Robert Christenson, Jessica Joyce, Elli A Park, Ashley Wu, Kathleen V Fitch, Sara E Looby, Michael T Lu, Udo Hoffmann, Steven K Grinspoon, Janet Lo
BACKGROUND: In observational studies, patients with HIV have higher levels of soluble ST2 (sST2), galectin-3, and growth differentiation factor-15 (GDF-15) than non-HIV controls. As statins exert pleiotropic immunomodulatory effects that may affect markers of myocardial fibrosis, the objective of the current study is to determine whether biomarkers of myocardial fibrosis reflecting subclinical pathology may be modified by statin therapy in patients with HIV. SETTING AND METHODS: Forty HIV+ men and women participated in a single center 12-month randomized, double-blind placebo-controlled trial of atorvastatin 40 mg every day vs...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29402827/expanded-haemodialysis-therapy-of-chronic-haemodialysis-patients-prevents-calcification-and-apoptosis-of-vascular-smooth-muscle-cells-in-vitro
#20
Kevin Willy, Matthias Girndt, Jakob Voelkl, Roman Fiedler, Peter Martus, Markus Storr, Ralf Schindler, Daniel Zickler
BACKGROUND: Vascular calcification is a common phenomenon in patients with chronic kidney disease and strongly associated with increased cardiovascular mortality. Vascular calcification is an active process mediated in part by inflammatory processes in vascular smooth muscle cells (VSMC). These could be modified by the insufficient removal of proinflammatory cytokines through conventional high-flux (HF) membranes. Recent trials demonstrated a reduction of inflammation in VSMC by use of dialysis membranes with a higher and steeper cut-off...
2018: Blood Purification
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