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https://www.readbyqxmd.com/read/27918822/growth-differentiation-factor-15-induced-contractile-activity-and-extracellular-matrix-production-in-human-trabecular-meshwork-cells
#1
Arumugam Ramachandran Muralidharan, Rupalatha Maddala, Nikolai P Skiba, Ponugoti Vasantha Rao
Purpose: To determine the role and regulation of growth differentiation factor-15 (GDF-15), a TGF-β-related cytokine in human trabecular meshwork (TM) cells in the context of aqueous humor (AH) outflow and IOP. Methods: Regulation of expression by external cues, and the distribution and secretion of GDF-15 by human TM primary cell cultures, and the effects of recombinant (r) GDF-15 on TM cell contractile characteristics, actin cytoskeleton, cell adhesion, extracellular matrix (ECM), α-smooth muscle actin (αSMA), SMAD signaling, and gene expression were determined by immunoblot, immunofluorescence, mass spectrometry, cDNA microarray, and real-time quantitative PCR (RT-qPCR) analyses...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27895795/growth-differentiating-factor-15-gdf-15-a-potential-biomarker-and-therapeutic-target-for-cancer-associated-weight-loss
#2
Lorena Lerner, Jeno Gyuris, Richard Nicoletti, James Gifford, Brian Krieger, Aminah Jatoi
Growth differentiating factor-15 (GDF-15), also known as macrophage inhibiting factor-1, is a member of the transforming growth factor-β superfamily, which has been implicated in cancer-associated weight loss. The present study investigated the association between cancer-associated weight loss and plasma GDF-15 concentration, as well as other biomarkers, in patients with metastatic lung or exocrine pancreatic cancer. A total of 218 patients were enrolled over a 1-year period. The patient cohort included 152 patients with incurable lung cancer and 66 patients with incurable pancreatic cancer...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27852365/-the-study-of-growth-differentiation-factor-15-in-chronic-thromboembolic-pulmonary-hypertension-following-acute-pulmonary-thromboembolism
#3
J X Xu, H Z Yu, Q Wu, J Mi
Objective: To evaluate the incidence of chronic thromboembolic pulmonary hypertension (CTEPH) secondary to acute pulmonary thromboembolism (PTE) and the serum level of growth differentiation factor-15(GDF-15). Methods: Ninety-six acute PTE patients were recruited in the study. Clinical data, Wells score, blood gas analysis, D-dimmer level, GDF-15 level, atrial and ventricular sizes, pulmonary arterial systolic pressure (PASP) and pulmonary artery CT (CTPA) data were collected. Patients were followed up to evaluate the cardiac function (WHO class), ultrasonic cardiogram and CTPA to confirm the incidence of CTEPH...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27832613/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-troponin-t-and-growth-differentiation-factor-15-in-adult-congenital-heart-disease
#4
Vivan J Baggen, Annemien van den Bosch, Jannet A Eindhoven, Anne-Rose Schut, Judith A A E Cuypers, Maarten Witsenburg, Monique de Waart, Ron H van Schaik, Felix Zijlstra, Eric Boersma, Jolien W Roos-Hesselink
BACKGROUND: -The number of patients with adult congenital heart disease (ACHD) is rapidly increasing. In order to optimize patient management, there is a great need to accurately identify high-risk patients. Still, no biomarker has been firmly established as a clinically useful prognostic tool in this group. We studied the association of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitive troponin-T (hs-TnT) and growth-differentiation factor 15 (GDF-15) with cardiovascular events in ACHD...
November 3, 2016: Circulation
https://www.readbyqxmd.com/read/27817223/discovery-of-biomarkers-for-endometrial-cancer-current-status-and-prospects
#5
Tea Lanišnik Rižner
Endometrial cancer is the most frequent gynecological malignancy in the developed world. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid noninvasive diagnostic methods available. Biomarkers for endometrial cancer would be invaluable for screening of high-risk women, detection of primary and recurrent disease, and preoperative stratification of patients as high-risk and low-risk categories, enabling personalized therapeutic approaches. Areas covered: This report reviews publications of blood biomarkers evaluated in patients with endometrial cancer and/or control patients, over the last five years...
December 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27811204/growth-differentiation-factor-15-predicts-all-cause-morbidity-and-mortality-in-stable-coronary-heart-disease
#6
Emil Hagström, Claes Held, Ralph A H Stewart, Philip E Aylward, Andrzej Budaj, Christopher P Cannon, Wolfgang Koenig, Sue Krug-Gourley, Emile R Mohler, Philippe Gabriel Steg, Elizabeth Tarka, Ollie Östlund, Harvey D White, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Higher growth differentiation factor 15 (GDF-15) concentrations are associated with cardiovascular (CV) and non-CV morbidity and mortality. However, information on associations between GDF-15 and the risk of specific CV and non-CV events in stable coronary heart disease (CHD) patients is limited. METHODS: In 14ü577 patients with stable CHD participating in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY), GDF-15 and other prognostic biomarkers (N-terminal pro-B-type natriuretic peptide, high-sensitivity troponin T, cystatin C, and high-sensitivity C-reactive protein) were measured...
November 3, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27766733/variability-of-biomarkers-in-patients-with-chronic-heart-failure-and-healthy-controls
#7
Wouter C Meijers, A Rogier van der Velde, Anneke C Muller Kobold, Janneke Dijck-Brouwer, Alan H Wu, Allan Jaffe, Rudolf A de Boer
AIMS: Biomarkers can be used for diagnosis, risk stratification, or management of patients with heart failure (HF). Knowledge about the biological variation is needed for proper interpretation of serial measurements. Therefore, we aimed to determine and compare the biological variation of a large panel of biomarkers in healthy subjects and in patients with chronic HF. METHODS AND RESULTS: The biological variability of established biomarkers [NT-proBNP and high-sensitivity troponin T (hsTnT)], novel biomarkers [galectin-3, suppression of tumorigenicity 2 (ST2), and growth differentiation factor 15 (GDF-15)], and renal/neurohormonal biomarkers (aldosterone, phosphate, parathyroid hormone, plasma renin concentration, and creatinine) was determined in 28 healthy subjects and 83 HF patients, over a period of 4 months and 6 weeks, respectively...
October 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27756762/gdf-15-is-associated-with-cancer-incidence-in-patients-with-type-2-diabetes
#8
Noemi Pavo, Raphael Wurm, Stephanie Neuhold, Christopher Adlbrecht, Greisa Vila, Guido Strunk, Martin Clodi, Michael Resl, Helmut Brath, Rudolf Prager, Anton Luger, Richard Pacher, Martin Hülsmann
BACKGROUND: Diabetes has been linked epidemiologically to increased cancer incidence and mortality. Growth differentiation factor 15 (GDF-15) is increased in patients with diabetes and has recently been linked to the occurrence of cancer. We investigated whether circulating GDF-15 concentrations can predict the incidence of malignant diseases in a diabetic patient cohort already facing increased risk for cancer. METHODS: We prospectively enrolled a total of 919 patients with type 2 diabetes and no history of malignant disease, who were clinically followed up for 60 months...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27747854/biomarkers-of-apoptosis-inflammation-and-cardiac-extracellular-matrix-remodeling-in-the-prognosis-of-heart-failure
#9
Pavel Osmancik, Anna Louckova
BACKGROUND: Heart failure (HF) belongs to the leading causes of morbidity and mortality. AIM: The aim of the review is to evaluate available literature on biomarkers of apoptosis, extracellular matrix remodelling, and recently established markers of inflammation in patients with HF. METHODS: Using the search words "Fas, "TRAIL", "apoptosis", "heart failure", "galectin-2, "ST-2", "metaloproteinase", "TGF- β1", "prognosis", "coronary artery diseases", and "dilated cardiomyopathy", a search was carried out...
October 17, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27734214/association-between-gdf-15-levels-and-changes-in-vascular-and-physical-function-in-older-patients-with-hypertension
#10
Maryam Barma, Faisel Khan, Rosemary J G Price, Peter T Donnan, C Martina Messow, Ian Ford, Alex McConnachie, Allan D Struthers, Marion E T McMurdo, Miles D Witham
BACKGROUND: Growth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension. AIMS: To correlate baseline GDF-15 levels with physical and vascular health data in this population. METHODS: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed...
October 12, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27728964/growth-differentiation-factor-15-predicts-chronic-liver-disease-severity
#11
Eaum Seok Lee, Seok Hyun Kim, Hyun Jin Kim, Kyung Hee Kim, Byung Seok Lee, Bon Jeong Ku
Background/Aims: Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was to determine the clinical performances of GDF-15 for the prediction of liver fibrosis and severity in chronic liver disease. Methods: The serum GDF-15 levels were examined via enzyme immunoassay in 145 patients with chronic liver disease and 101 healthy individuals. The patients with chronic liver disease consisted of 54 patients with chronic hepatitis, 44 patients with compensated liver cirrhosis, and 47 patients with decompensated liver cirrhosis...
October 13, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27717384/preoperative-plasma-growth-differentiation-factor-15-for-prediction-of-acute-kidney-injury-in-patients-undergoing-cardiac-surgery
#12
Matthias Heringlake, Efstratios I Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann
BACKGROUND: Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in patients undergoing cardiac surgery, is associated with poor prognosis. The present secondary analysis of an observational cohort study aimed to determine the role of GDF-15 in predicting CSA-AKI compared with the Cleveland-Clinic Acute Renal Failure (CC-ARF) score and a logistic regression model including variables associated with renal dysfunction...
October 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27705749/high-gdf-15-serum-levels-independently-correlate-with-poorer-overall-survival-of-tumor-free-stage-iii-and-unresectable-stage-iv-melanoma-patients
#13
Benjamin Weide, Tina Schäfer, Alexander Martens, Anastasia Kuzkina, Laura Uder, Seema Noor, Claus Garbe, Patrick N Harter, Michel Mittelbronn, Jörg Wischhusen
Biomarkers are strongly needed for diagnostic surveillance of metastatic melanoma patients. Based on its known association with tumor metastasis and its ability to induce cancer cachexia we investigated serum levels of growth and differentiation factor 15 (sGDF-15) as marker for overall survival (OS). sGDF-15 was retrospectively measured by ELISA in 761 samples obtained at distinct time points during routine clinical care of stage III/IV melanoma patients. In the entire cohort sGDF-15 ≥1.5ng/mL was strongly associated with reduced OS after assessment...
July 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27684606/effects-of-cigarette-smoking-on-cardiovascular-related-protein-profiles-in-two-community-based-cohort-studies
#14
Biying Huang, Per Svensson, Johan Ärnlöv, Johan Sundström, Lars Lind, Erik Ingelsson
BACKGROUND AND AIMS: Cardiovascular diseases account for the largest fraction of smoking-induced deaths. Studies of smoking in relation to cardiovascular-related protein markers can provide novel insights into the biological effects of smoking. We investigated the associations between cigarette smoking and 80 protein markers known to be related to cardiovascular diseases in two community-based cohorts, the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n = 969, 50% women, all aged 70 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 717, all men aged 77 years)...
September 15, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27679935/serum-gdf-15-level-in-rheumatoid-arthritis-relationship-with-disease-activity-and-subclinical-atherosclerosis
#15
Osman Tanrıkulu, Mustafa Akif Sarıyıldız, İbrahim Batmaz, Levent Yazmalar, Nihat Polat, İbrahim Kaplan, Remzi Çevik
OBJECTIVES: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activated macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with disease-related characteristics in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study...
July 30, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27642607/gdf-15-and-hepcidin-levels-in-nonanemic-patients-with-impaired-glucose-tolerance
#16
Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Mujde Akturk, Ozlem Gulbahar, Emre Arslan, Damla Ors Sendogan, Ilhan Yetkin, Fusun Balos Toruner
Aims. Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition. Current data is conflicting about the relationship between hepcidin and disorders of glucose metabolism. We aimed to investigate serum hepcidin and GDF-15 concentrations and their associations with each other, in nonanemic subjects with impaired glucose tolerance (IGT) in comparison with the nonanemic subjects with normal glucose tolerance (NGT). Methods...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27609943/discovery-of-new-biomarkers-for-atrial-fibrillation-using-a-custom-made-proteomics-chip
#17
Lars Lind, Johan Sundström, Markus Stenemo, Emil Hagström, Johan Ärnlöv
BACKGROUND: Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice. OBJECTIVE: To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk. METHODS: In two independent community-based cohorts (Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (978 participants without AF, mean age 70...
September 8, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27566082/high-dose-radiation-induced-heart-damage-in-a-rat-model
#18
Laura Kiscsatári, Márta Sárközy, Bence Kővári, Zoltán Varga, Kamilla Gömöri, Nikolett Morvay, István Leprán, Hargita Hegyesi, Gabriella Fábián, Bálint Cserni, Gábor Cserni, Tamás Csont, Zsuzsanna Kahán
BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested. RESULTS: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27541645/nt-probnp-is-a-powerful-predictor-for-incident-atrial-fibrillation-validation-of-a-multimarker-approach
#19
Emma Svennberg, Bertil Lindahl, Lars Berglund, Kai M Eggers, Per Venge, Björn Zethelius, Mårten Rosenqvist, Lars Lind, Ziad Hijazi
BACKGROUND: Biomarkers may be of value to identify individuals at risk of developing atrial fibrillation (AF). Using a multimarker approach, this study investigated if the biomarkers; NT-proBNP, high-sensitivity cardiac troponin (hs-cTn), growth differentiation factor-15 (GDF-15), cystatin C and high-sensitivity C-reactive protein (CRP) are independent predictors for incident AF. METHODS: Blood samples were collected from 883 individuals in the Uppsala Longitudinal Study of Adult Men (ULSAM) and 978 individuals in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27540030/prognostic-utility-of-galectin-3-for-recurrent-cardiovascular-events-during-long-term-follow-up-in-patients-with-stable-coronary-heart-disease-results-of-the-karola-study
#20
Henning Jansen, Wolfgang Koenig, Andrea Jaensch, Ute Mons, Lutz P Breitling, Hubert Scharnagl, Tatjana Stojakovic, Heribert Schunkert, Hermann Brenner, Dietrich Rothenbacher
BACKGROUND: Galectin-3 has emerged as a potential useful novel biomarker for heart failure and cardiovascular disease (CVD). However, it remains unclear whether galectin-3 is associated with recurrent cardiovascular events during long-term follow-up of patients with stable coronary heart disease (CHD) after adjustment for multiple established and novel risk factors. METHODS: We measured galectin-3 at baseline in a cohort consisting of 1035 CHD patients and followed them for 13 years to assess a combined CVD end point...
October 2016: Clinical Chemistry
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