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https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#1
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028227/a-strong-tb-programme-embedded-in-a-developing-primary-healthcare-system-is-a-lose-lose-situation-insights-from-patient-and-community-perspectives-in-cambodia
#2
Neisha Sundaram, Richard James, Um Sreynimol, Pen Linda, Joanne Yoong, Saint Saly, Pichenda Koeut, Mao Tan Eang, Richard Coker, Mishal S Khan
As exemplified by the situation in Cambodia, disease specific (vertical) health programmes are often favoured when the health system is fragile. The potential of such an approach to impede strengthening of primary healthcare services has been studied from a health systems perspective in terms of access and quality of care. In this bottom-up, qualitative study we investigate patient and community member experiences of health services when a strong tuberculosis (TB) programme is embedded into a relatively underutilized primary healthcare system...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28992560/effectiveness-and-tolerability-of-perampanel-in-children-adolescents-and-young-adults-with-refractory-epilepsy-a-uk-national-multicentre-study
#3
N Swiderska, H J Tan, A Rajai, A Silwal, A Desurkar, T Martland
PURPOSE: Perampanel is one of the latest antiepileptic drugs (AEDs) approved for the treatment of focal and generalised epilepsy in individuals with epilepsy aged 12 years and older. There is sparse data on the use of Perampanel in children under 12. We conducted a study amongst paediatric neurologists in the United Kingdom to investigate its effectiveness and tolerability as an adjunctive therapy in children of all ages with refractory epilepsy. METHODS: Data was collected via an online questionnaire sent to paediatric neurologists in the UK...
September 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28976044/prevalence-and-predictors-of-sunburn-among-beachgoers
#4
M de Troya-Martín, M V de Gálvez-Aranda, F Rivas-Ruiz, N Blázquez-Sánchez, M T Fernández-Morano, L Padilla-España, E Herrera-Ceballos
BACKGROUND: Painful sunburns at any age are one of the main risk factors for skin cancer. OBJECTIVES: To determine the prevalence and predictors of sunburn among beachgoers. METHODS: A cross-sectional health survey was conducted at the beach during the summer. Adults > 18 years with an understanding of Spanish were interviewed using a questionnaire about behaviours, attitudes and knowledge related to sun exposure at the beach. A descriptive analysis was performed and a log binomial regression model was used to determine predictors of sunburn...
October 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28975805/associations-between-narrative-transportation-risk-perception-and-behaviour-intentions-following-narrative-messages-about-skin-cancer
#5
Amanda J Dillard, Rebecca A Ferrer, Jessica D Welch
OBJECTIVE: Narrative messages may be an effective strategy to increase risk perceptions and motivate preventive behaviours related to cancer. The aim of this research was to examine associations between narrative transportation (i.e. psychological absorption into a narrative), risk perceptions, and intentions following narrative messages about skin cancer. DESIGN: In two studies, women who reported indoor tanning read first-person narrative messages about skin cancer...
October 4, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28902840/maternal-gut-bacteria-promote-neurodevelopmental-abnormalities-in-mouse-offspring
#6
Sangdoo Kim, Hyunju Kim, Yeong Shin Yim, Soyoung Ha, Koji Atarashi, Tze Guan Tan, Randy S Longman, Kenya Honda, Dan R Littman, Gloria B Choi, Jun R Huh
Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In pregnant mice, interleukin-17a (IL-17a) produced by T helper 17 (TH17) cells (CD4(+) T helper effector cells involved in multiple inflammatory conditions) induces behavioural and cortical abnormalities in the offspring exposed to MIA...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28894399/drosophila-melanogaster-deciphering-alzheimer-s-disease
#7
REVIEW
Florence Hui Ping Tan, Ghows Azzam
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder worldwide. Its pathogenesis involves two hallmarks: aggregation of amyloid beta (Aβ) and occurrence of neurofibrillary tangles (NFTs). The mechanism behind the disease is still unknown. This has prompted the use of animal models to mirror the disease. The fruit fly, Drosophila melanogaster has garnered considerable attention as an organism to recapitulate human disorders. With the ability to monopolise a multitude of traditional and novel genetic tools, Drosophila is ideal for studying not only cellular aspects but also physiological and behavioural traits of human neurodegenerative diseases...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28881002/clinician-targeted-interventions-to-influence-antibiotic-prescribing-behaviour-for-acute-respiratory-infections-in-primary-care-an-overview-of-systematic-reviews
#8
REVIEW
Sarah Kg Tonkin-Crine, Pui San Tan, Oliver van Hecke, Kay Wang, Nia W Roberts, Amanda McCullough, Malene Plejdrup Hansen, Christopher C Butler, Chris B Del Mar
BACKGROUND: Antibiotic resistance is a worldwide health threat. Interventions that reduce antibiotic prescribing by clinicians are expected to reduce antibiotic resistance. Disparate interventions to change antibiotic prescribing behaviour for acute respiratory infections (ARIs) have been trialled and meta-analysed, but not yet synthesised in an overview. This overview synthesises evidence from systematic reviews, rather than individual trials. OBJECTIVES: To systematically review the existing evidence from systematic reviews on the effects of interventions aimed at influencing clinician antibiotic prescribing behaviour for ARIs in primary care...
September 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28844889/aiding-sleep-in-type-2-diabetes-therapeutic-considerations
#9
REVIEW
Xiao Tan, Lieve van Egmond, Colin D Chapman, Jonathan Cedernaes, Christian Benedict
Insomnia and obstructive sleep apnoea (OSA) are more prevalent in patients with type 2 diabetes than in the general population. Both insomnia and OSA have been linked to cardiometabolic alterations (eg, hypertension, increased activity of the sympathetic nervous system, and systemic insulin resistance) that can exacerbate the pathophysiology of type 2 diabetes. Improvement of sleep in patients with diabetes could therefore aid the treatment of diabetes. To help health practitioners choose the best clinical tool to improve their patients' sleep without detrimentally affecting glucose regulation, this Review critically analyses the effects of common treatments for insomnia and OSA on both sleep and glucose metabolism in patients with type 2 diabetes...
August 24, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28839245/hypermasculinised-facial-morphology-in-boys-and-girls-with-autism-spectrum-disorder-and-its-association-with-symptomatology
#10
Diana Weiting Tan, Syed Zulqarnain Gilani, Murray T Maybery, Ajmal Mian, Anna Hunt, Mark Walters, Andrew J O Whitehouse
Elevated prenatal testosterone exposure has been associated with Autism Spectrum Disorder (ASD) and facial masculinity. By employing three-dimensional (3D) photogrammetry, the current study investigated whether prepubescent boys and girls with ASD present increased facial masculinity compared to typically-developing controls. There were two phases to this research. 3D facial images were obtained from a normative sample of 48 boys and 53 girls (3.01-12.44 years old) to determine typical facial masculinity/femininity...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828235/rna-sequencing-rna-seq-of-lymph-node-spleen-and-thymus-transcriptome-from-wild-peninsular-malaysian-cynomolgus-macaque-macaca-fascicularis
#11
Joey Ee Uli, Christina Seok Yien Yong, Swee Keong Yeap, Jeffrine J Rovie-Ryan, Nurulfiza Mat Isa, Soon Guan Tan, Noorjahan Banu Alitheen
The cynomolgus macaque (Macaca fascicularis) is an extensively utilised nonhuman primate model for biomedical research due to its biological, behavioural, and genetic similarities to humans. Genomic information of cynomolgus macaque is vital for research in various fields; however, there is presently a shortage of genomic information on the Malaysian cynomolgus macaque. This study aimed to sequence, assemble, annotate, and profile the Peninsular Malaysian cynomolgus macaque transcriptome derived from three tissues (lymph node, spleen, and thymus) using RNA sequencing (RNA-Seq) technology...
2017: PeerJ
https://www.readbyqxmd.com/read/28810391/predictors-of-diet-failure-a-multifactorial-cognitive-and-behavioural-model
#12
Kiera Buchanan, Jeanie Sheffield, Wee Hong Tan
Obesity is recognised as a multidetermined issue. However, research aimed at addressing diet failure has typically examined factors in isolation. Furthermore, previous research has included limited input from dieters themselves. A qualitative study identified a number of themes contributing to diet failure. This study aimed to test these themes with a larger sample ( n = 426) while also determining their fit within a multifactorial model. The results of this study supported the conceptualisation of diet failure using a multifactorial model while also illustrating correlational pathways to be more complex than currently understood in the literature...
January 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28805849/topology-of-polymer-chains-under-nanoscale-confinement
#13
Vahid Satarifard, Maziar Heidari, Samaneh Mashaghi, Sander J Tans, Mohammad Reza Ejtehadi, Alireza Mashaghi
Spatial confinement limits the conformational space accessible to biomolecules but the implications for bimolecular topology are not yet known. Folded linear biopolymers can be seen as molecular circuits formed by intramolecular contacts. The pairwise arrangement of intra-chain contacts can be categorized as parallel, series or cross, and has been identified as a topological property. Using molecular dynamics simulations, we determine the contact order distributions and topological circuits of short semi-flexible linear and ring polymer chains with a persistence length of lp under a spherical confinement of radius Rc...
August 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28797480/can-acclimation-of-thermal-tolerance-in-adults-and-across-generations-act-as-a-buffer-against-climate-change-in-tropical-marine-ectotherms
#14
S A Morley, K D Nguyen, L S Peck, C-H Lai, K S Tan
Thermal acclimation capacity was investigated in adults of three tropical marine invertebrates, the subtidal barnacle Striatobalanus amaryllis, the intertidal gastropod Volegalea cochlidium and the intertidal barnacle Amphibalanus amphitrite. To test the relative importance of transgenerational acclimation, the developmental acclimation capacity of A. amphitrite was investigated in F1 and F2 generations reared at a subset of the same incubation temperatures. The increase in CTmax (measured through loss of key behavioural metrics) of F0 adults across the incubation temperature range 25...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28782378/-it-s-bit-of-an-eye-opener-a-qualitative-study-of-women-s-attitudes-towards-tanning-sun-protection-and-a-facial-morphing-intervention
#15
Sofia Persson, Sarah Grogan, Katie Dhingra, Yael Benn
OBJECTIVE: Skin cancer is to a large degree behaviourally preventable, meaning that evidence-based interventions have scope to make a difference. Previous research indicates that appearance-based interventions such as facial morphing may be more effective than health-based interventions, and that it can personalise the issue of skin cancer. METHOD: This study examined attitudes to UV exposure, as well as reactions to a facial morphing intervention, through interviews with 25 women aged 35 years and older...
August 7, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28773918/synthesis-and-characterization-of-types-a-and-b-gelatin-methacryloyl-for-bioink-applications
#16
Bae Hoon Lee, Nathaniel Lum, Li Yuan Seow, Pei Qi Lim, Lay Poh Tan
Gelatin methacryloyl (GelMA) has been increasingly considered as an important bioink material due to its tailorable mechanical properties, good biocompatibility, and ability to be photopolymerized in situ as well as printability. GelMA can be classified into two types: type A GelMA (a product from acid treatment) and type B GelMA (a product from alkali treatment). In current literature, there is little research on the comparison of type A GelMA and type B GelMA in terms of synthesis, rheological properties, and printability for bioink applications...
September 24, 2016: Materials
https://www.readbyqxmd.com/read/28769008/ketamine-alleviates-depressive-like-behaviors-via-down-regulating-inflammatory-cytokines-induced-by-chronic-restraint-stress-in-mice
#17
Sijie Tan, Yan Wang, Ke Chen, Zhifeng Long, Ju Zou
The purpose of the present study was to investigate whether ketamine's rapid antidepressant effects were associated with its anti-inflammatory actions and to explore the underlying molecular mechanism. Depressive-like behaviors was induced in mice using chronic restraint stress (CRS) method. Anti-depressive effects of ketamine were evaluated by forced swimming tests (FST) and sucrose preference test (SPT). Subsequently, brain tissue was harvested to investigate inflammatory response in the hippocampus via investigating reactive microglia numbers, serum cytokines levels and the toll-like receptor type 4 (TLR4)/p38 mitogen-activated protein kinase (MAPK) pathway...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28739131/ibudilast-reduces-oxaliplatin-induced-tactile-allodynia-and-cognitive-impairments-in-rats
#18
Ian N Johnston, Manuela Tan, Jacob Cao, Antigone Matsos, Daniel R L Forrest, Emily Si, Joanna E Fardell, Mark R Hutchinson
Chemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection...
July 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28716746/controlled-release-and-anti-proliferative-effect-of-imatinib-mesylate-loaded-sporopollenin-microcapsules-extracted-from-pollens-of-betula-pendula
#19
Idris Sargin, Lalehan Akyuz, Murat Kaya, Gamze Tan, Talip Ceter, Kevser Yildirim, Seymanur Ertosun, Gozde Hatun Aydin, Muge Topal
Sporopollenin is a promising material for drug encapsulation due to its excellent properties; uniformity in size, non-toxicity, chemically and thermally resilient nature. Herein, morphologically intact sporopollenin microcapsules were extracted from Betula pendula pollens. Cancer therapeutic agent (imatinib mesylate) was loaded into the microcapsules. The encapsulation efficiency by passive loading technique was found to be 21.46%. Release behaviour of the drug from microcapsules was found to be biphasic, with an initial fast release followed by a slower rate of release...
July 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28703883/associations-between-cardiovascular-disease-and-its-risk-factors-with-hearing-loss-a-cross-sectional-analysis
#20
Hsern Ern Ivan Tan, Nick Si Rui Lan, Matthew William Knuiman, Mark Laurence Divitini, De Wet Swanepoel, Michael Hunter, Christopher Gerard Brennan-Jones, Joseph Hung, Robert Henry Eikelboom, Peter Luke Santa Maria
OBJECTIVES: To investigate the relationship between hearing loss and cardiovascular disease risk factors. DESIGN: Cross-sectional study. METHODS: Participants were recruited between May 2010 and December 2015 and answered a health and risk factor questionnaire. Physical and biochemical assessments were performed. SETTING: A community based population. PARTICIPANTS: 5,107 participants born within the years 1946-1964 enrolled in the Busselton Healthy Ageing Study...
July 13, 2017: Clinical Otolaryngology
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