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https://www.readbyqxmd.com/read/29866057/chinese-cases-of-early-infantile-epileptic-encephalopathy-a-novel-mutation-in-the-pcdh19-gene-was-proved-in-a-mosaic-male-case-report
#1
Yuxia Tan, Mei Hou, Shaochun Ma, Peipei Liu, Shungang Xia, Yu Wang, Liping Chen, Zongbo Chen
BACKGROUND: The link between the protocadherin-19 (PCDH19) gene and epilepsy suggests that an unusual form of X-linked inheritance affects females but is transmitted through asymptomatic males. Individuals with epilepsy associated with mutations in the PCDH19 gene display generalized or focal seizures with or without fever sensitivity. The clinical manifestation of the condition ranges from mild to severe, resulting in intellectual disability and behavioural disturbance. In the present study, we assessed mutations in the PCDH19 gene and the clinical features of a group of Chinese patients with early infantile epileptic encephalopathy and aimed to provide further insight into the understanding of epilepsy and mental retardation limited to females (EFMR; MIM 300088)...
June 4, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29858632/constitutive-melanin-density-is-associated-with-higher-25-hydroxyvitamin-d-and-potentially-total-body-bmd-in-older-caucasian-adults-via-increased-sun-tolerance-and-exposure
#2
M J W Thompson, G Jones, D A Aitken
Greater skin pigmentation reduces dose equivalent cutaneous vitamin D3 production, potentially impacting lifetime vitamin D status and fracture risk. We show that melanin density was positively associated with 25-hydroxyvitamin D and total body bone mineral density. These relationships were partially explained by greater sun exposure due to more permissive skin phenotype. INTRODUCTION: Higher cutaneous melanin reduces vitamin D3 production. This may impact lifetime vitamin D status and increase fracture risk...
June 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29754013/psychogenic-nonepileptic-seizures-in-adults-with-epilepsy-and-intellectual-disability-a-neglected-area
#3
Jans S van Ool, Alexandra I Haenen, Francesca M Snoeijen-Schouwenaars, Albert P Aldenkamp, Jos G M Hendriksen, H Jurgen Schelhaas, In Y Tan, Richard H C Lazeron, Nynke M G Bodde
PURPOSE: To describe the main characteristics of psychogenic nonepileptic seizures (PNES) in adults with epilepsy and intellectual disability (ID), and to analyse the differences regarding psychosocial functioning, epilepsy severity and ID between patients with PNES and a control group without PNES. METHODS: Medical records of adults with ID and epilepsy living at an epilepsy care facility (N = 240) were screened for PNES and evaluated by a neurologist. A control group consisting of patients with epilepsy and ID, without PNES, was matched according to age, sex and level of ID...
May 4, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29736327/the-effect-of-using-games-in-teaching-conservation
#4
Cedric Kai Wei Tan, Jiin Woei Lee, Adeline Hii, Yen Yi Loo, Ahimsa Campos-Arceiz, David W Macdonald
Games are an increasingly popular approach for conservation teaching. However, we know little about the effectiveness of the games on students' experiences and knowledge acquisition. Many current games are supplemental games (SG) that have no meaningful interaction with the subject matter. We adapted the experiential gaming (EG) model where students were immersed in goal-orientated tasks found in real-life situations, and they tackled questions to complete actions for their main task. Classroom-based games were created for eight different conservation topics for an annual Wildlife Conservation Course and an annual Diploma in International Wildlife Conservation Practice...
2018: PeerJ
https://www.readbyqxmd.com/read/29707955/do-schizotypy-dimensions-reflect-the-symptoms-of-schizophrenia
#5
Elizabeth Hx Thomas, Susan L Rossell, Eric J Tan, Erica Neill, Tamsyn E Van Rheenen, Sean P Carruthers, Philip J Sumner, Stephanie Louise, Kiymet Bozaoglu, Caroline Gurvich
OBJECTIVE: The personality characteristics and symptoms observed in schizophrenia are postulated to lie on a continuum, with non-clinical manifestations referred to as schizotypy. High schizotypy behaviours are argued to correspond with the three main clusters of symptoms in schizophrenia: positive, negative and cognitive/disorganised symptoms, yet there is limited empirical evidence to support this. This study aimed to investigate whether schizotypy dimensions significantly correlate with their respective schizophrenia symptomatology in the largest sample to date...
April 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29705756/cohort-profile-china-respiratory-illness-surveillance-among-pregnant-women-crisp-2015-2018
#6
Liling Chen, Suizan Zhou, Zhongwei Zhang, Yan Wang, Lin Bao, Yayun Tan, Falin Sheng, Ying Song, Ran Zhang, A Danielle Iuliano, Mark G Thompson, Carolyn M Greene, Jun Zhang
PURPOSE: We established the China Respiratory Illness Surveillance among Pregnant women (CRISP) to conduct active surveillance for influenza-associated respiratory illness during pregnancy in China from 2015 to 2018. Among annual cohorts of pregnant women, we assess the incidence of acute respiratory illness (ARI), influenza-like illness (ILI), laboratory-confirmed influenza virus infection and the seroconversion proportion during the winter influenza season. We also plan to examine the effect of influenza virus infection on adverse pregnancy, delivery and infant health outcomes with cumulative data from the three annual cohorts...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29704387/the-crucial-role-of-molecular-testing-to-facilitate-the-diagnosis-of-pneumocystis-pneumonia-during-pregnancy
#7
C H Ding, H Yusoff, N A S Muttaqillah, Y L Tang, T L Tan, P Periyasamy, A Y L Ban
Pneumocystis pneumonia is an important human immunodeficiency virus (HIV)-associated opportunistic infection, and especially so in pregnant HIV-positive patients. We report a case of a 40-year-old woman in her first trimester of pregnancy who initially presented with acute gastroenteritis symptoms but due to a history of high-risk behaviour and the observation of oral thrush, she was worked up for HIV infection. Her retroviral status was positive and her CD4+ T cell count was only 8 cells/µL. She was also worked up for pneumocystis pneumonia due to the presence of mild resting tachypnoea and a notable drop in oxygen saturation (from 100% to 88%) following brief ambulation...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29695211/continuation-of-oral-nutritional-supplementation-supports-continued-growth-in-nutritionally-at-risk-children-with-picky-eating-behaviour-a-post-intervention-observational-follow-up-study
#8
Apurba K Ghosh, Bala Kishore, Irfan Shaikh, Vinita Satyavrat, Anil Kumar, Tapan Shah, Prahlad Pote, Sandeep Shinde, Yatin Berde, Yen Ling Low, Verena M H Tan, Dieu T T Huynh
Objectives To evaluate the 120-day post-intervention growth trajectory of picky-eating children aged 2 to 6 years who previously completed a 90-day, randomized, controlled trial of oral nutritional supplementation (ONS) plus dietary counselling (DC) (SDC, n = 98) compared with DC alone (n = 105). Methods A total of 203 children were included. Children were free to consume ONS during follow-up. Information on ONS consumption was collected. Weight-for-age percentile (WAP) and height-for-age percentile (HAP) were measured at Day 90 (beginning) and Day 210 (end point)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29674662/hard-magnetic-properties-in-nanoflake-van-der-waals-fe-3-gete-2
#9
Cheng Tan, Jinhwan Lee, Soon-Gil Jung, Tuson Park, Sultan Albarakati, James Partridge, Matthew R Field, Dougal G McCulloch, Lan Wang, Changgu Lee
Two-dimensional van der Waals materials have demonstrated fascinating optical and electrical characteristics. However, reports on magnetic properties and spintronic applications of van der Waals materials are scarce by comparison. Here, we report anomalous Hall effect measurements on single crystalline metallic Fe3 GeTe2 nanoflakes with different thicknesses. These nanoflakes exhibit a single hard magnetic phase with a near square-shaped magnetic loop, large coercivity (up to 550 mT at 2 K), a Curie temperature near 200 K and strong perpendicular magnetic anisotropy...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29655885/short-term-retrogradation-behaviour-of-corn-starch-is-inhibited-by-the-addition-of-porcine-plasma-protein-hydrolysates
#10
Haili Niu, Qi Han, Chuanai Cao, Qian Liu, Baohua Kong
The potential inhibition of porcine plasma protein hydrolysates (PPPH) on the short-term retrogradation of corn starch (CS) was investigated. Compared with native CS, PPPH significantly enhanced breakdown and decreased the total setback in a rapid visco analyser (RVA) measurement (P < 0.05). Dynamic time sweep analysis of pre-prepared gelatinized samples showed a decrease in the storage modulus (G') and increase in the loss tangent (tan δ) in the presence of PPPH. Differential scanning calorimetry results showed that PPPH significantly reduced the gelatinization enthalpies (ΔHg) and retrogradation enthalpies (ΔHr) of CS (P < 0...
April 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29618384/self-reported-domain-specific-and-accelerometer-based-physical-activity-and-sedentary-behaviour-in-relation-to-psychological-distress-among-an-urban-asian-population
#11
A H Y Chu, R M van Dam, S J H Biddle, C S Tan, D Koh, F Müller-Riemenschneider
BACKGROUND: The interpretation of previous studies on the association of physical activity and sedentary behaviour with psychological health is limited by the use of mostly self-reported physical activity and sedentary behaviour, and a focus on Western populations. We aimed to explore the association of self-reported and devise-based measures of physical activity and sedentary behaviour domains on psychological distress in an urban multi-ethnic Asian population. METHODS: From a population-based cross-sectional study of adults aged 18-79 years, data were used from an overall sample (n = 2653) with complete self-reported total physical activity/sedentary behaviour and domain-specific physical activity data, and a subsample (n = 703) with self-reported domain-specific sedentary behaviour and accelerometry data...
April 5, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29614897/effect-of-oral-nutritional-supplementation-on-growth-and-recurrent-upper-respiratory-tract-infections-in-picky-eating-children-at-nutritional-risk-a-randomized-controlled-trial
#12
Apurba K Ghosh, Bala Kishore, Irfan Shaikh, Vinita Satyavrat, Anil Kumar, Tapan Shah, Prahlad Pote, Sandeep Shinde, Yatin Berde, Yen Ling Low, Verena M H Tan, Dieu T T Huynh
Objectives To evaluate the effect of oral nutritional supplementation (ONS) plus dietary counselling (DC) (intervention) versus DC alone (control) on growth and upper respiratory tract infection (URTI) in nutritionally at-risk, picky eating children in India. Methods We performed a 90-day, prospective, randomized, controlled trial. A total of 255 children aged 24-72 months with a weight-for-age z-score ≥-2 and <-1, picky eating behaviour, and acute URTI were randomized to the control (n = 128) or intervention group (n = 127)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29609000/eating-in-the-absence-of-hunger-stability-over-time-and-associations-with-eating-behaviours-and-body-composition-in-children
#13
Anna Fogel, Keri Mccrickerd, Lisa R Fries, Ai Ting Goh, Phaik Ling Quah, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary Foong Fong Chong, Ciarán G Forde
BACKGROUND/OBJECTIVES: Eating in the absence of hunger (EAH) has been linked to obesity in adults and children. This study examined the stability of EAH in children between 4.5 and 6 years old, and associations with energy intake and portion selection, as well as cross-sectional and prospective associations with body composition. METHODS: The participants were 158 boys and girls from the Growing Up in Singapore Towards healthy Outcomes cohort. At ages 4.5 and 6 years old children were provided lunch ad libitum, and immediately afterwards were exposed to palatable snacks to measure energy intake in the absence of hunger...
March 30, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29587691/trends-in-unprotected-intercourse-among-heterosexual-men-before-and-after-brothel-ban-in-siem-reap-cambodia-a-serial-cross-sectional-study-2003-2012
#14
Mee Lian Wong, Alvin Kuo Jing Teo, Bee Choo Tai, Alwyn Mao Tong Ng, Raymond Boon Tar Lim, Dede Kam Tyng Tham, Nashwinder Kaur, Rayner Kay Jin Tan, Sarath Kros, Savun Touch, Maryan Chhit, Ian Lubek
BACKGROUND: Following Cambodia's implementation of the 100% condom use program with enforcement of condom use and STI treatment services for sex workers in 2001, sexually transmitted infection and HIV declined markedly. In 2008, Cambodia implemented a law to ban brothel-based sex work. We reported trends in unprotected vaginal intercourse with sex workers among heterosexual men buying sex before (2003-2008) and after (2009-2012) the brothel ban in Cambodia. We also determined the association of brothel ban with these men's reports of unprotected intercourse with sex workers...
March 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29551400/oral-processing-behaviours-that-promote-children-s-energy-intake-are-associated-with-parent-reported-appetitive-traits-results-from-the-gusto-cohort
#15
Anna Fogel, Lisa R Fries, Keri McCrickerd, Ai Ting Goh, Phaik Ling Quah, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary Foong Fong Chong, Ciarán G Forde
Oral processing behaviours associated with faster eating rates have been consistently linked to increased energy intakes, but little is known about their links to children's appetitive traits. This study used the Child Eating Behaviour Questionnaire (CEBQ) to explore cross-sectional and prospective associations between parent-reported appetitive traits and observed oral processing behaviours. Participants were 195 children from the Growing Up in Singapore Towards healthy Outcomes cohort, who participated in a video-recorded ad libitum lunch at 4...
March 15, 2018: Appetite
https://www.readbyqxmd.com/read/29551079/a-dimensional-approach-to-thought-disturbances-in-epilepsy-utility-in-psychosis-and-behavioural-syndromes
#16
Islam Hassan, Tiffany Townsend, Jing Ee Tan, Chantelle Hrazdil
No abstract text is available yet for this article.
March 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29549250/archimedes-law-explains-penetration-of-solids-into-granular-media
#17
Wenting Kang, Yajie Feng, Caishan Liu, Raphael Blumenfeld
Understanding the response of granular matter to intrusion of solid objects is key to modelling many aspects of behaviour of granular matter, including plastic flow. Here we report a general model for such a quasistatic process. Using a range of experiments, we first show that the relation between the penetration depth and the force resisting it, transiently nonlinear and then linear, is scalable to a universal form. We show that the gradient of the steady-state part, K ϕ , depends only on the medium's internal friction angle, ϕ, and that it is nonlinear in μ = tan ϕ, in contrast to an existing conjecture...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29541959/extracellular-vesicle-carried-jagged-1-inhibits-huvec-sprouting-in-a-3d-microenvironment
#18
Evan Tan, Harry H Asada, Ruowen Ge
NOTCH signalling is an evolutionarily conserved juxtacrine signalling pathway that is essential in development. Jagged1 (JAG1) and Delta-like ligand 4 (DLL4) are transmembrane NOTCH ligands that regulate angiogenesis by controlling endothelial cell (EC) differentiation, vascular development and maturation. In addition, DLL4 could bypass its canonical cell-cell contact-dependent signalling to influence NOTCH signalling and angiogenesis at a distance when it is packaged into extracellular vesicles (EVs). However, it is not clear whether JAG1 could also be packaged into EVs to influence NOTCH signalling and angiogenesis...
March 14, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29533482/decrease-in-artificial-tanning-by-french-teenagers-2011-2016
#19
Matthieu Say, Alain Beauchet, Ioannis Vouldoukis, Pascale Beauchet, Monique Boudet, Emilie Tella, Emmanuel Mahé
BACKGROUND: The major risk factor for skin cancers is exposure to solar and artificial ultraviolet radiation, in particular during childhood and adolescence. In France, a law was restricted for tanning-bed access to adults (≥18 years) since 1997. OBJECTIVE: To evaluate teenagers' artificial tanning behaviour in 2016 and to compare results with those obtained in a similar survey performed in 2011. METHODS: The SOLADO 2011 and 2016 surveys were conducted in a general school in Antony and a technical school in Fontenay-aux-Roses (Paris suburb)...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29521010/medication-adherence-in-first-episode-psychosis-patients-in-singapore
#20
Chunzhen Tan, Edimansyah Abdin, Wilfred Liang, Lye Yin Poon, Ngar Yee Poon, Swapna Verma
AIM: Early intervention programmes for first episode psychosis (FEP) aim to reduce the duration of untreated psychosis (DUP) and improve functional outcomes. The sustained maintenance of improved outcomes depends largely on patients' adherence to prescribed treatment. This paper examines the prevalence of non-adherence in a cohort of patients with FEP and the sociodemographic and clinical factors associated with non-adherent behaviour. METHODS: The sample included consecutive patients accepted from 2007 to 2012 into the Early Psychosis Intervention Programme (EPIP) in Singapore...
March 9, 2018: Early Intervention in Psychiatry
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