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https://www.readbyqxmd.com/read/28550530/rtms-ameliorates-ptsd-symptoms-in-rats-by-enhancing-glutamate-transmission-and-synaptic-plasticity-in-the-acc-via-the-pten-akt-signalling-pathway
#1
Gaohua Liu, Dayun Feng, Jian Wang, Haifeng Zhang, Zhengwu Peng, Min Cai, Jing Yang, Ruiguo Zhang, Huaning Wang, Shengxi Wu, Qingrong Tan
Repetitive transcranial magnetic stimulation (rTMS) is a novel physiological therapy that has been adopted to clinically treat psychiatric disorders. Our previous study indicated the potential therapeutic effect of rTMS on posttraumatic stress disorder (PTSD). However, the exact molecular mechanism is elusive. Currently, using the single prolonged stress (SPS) rat model for PTSD, we investigated the glutamatergic transmission and neural plasticity changes in the anterior cingulate cortex (ACC) after SPS induction and explored the protective effects and mechanism of rTMS treatment...
May 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28540394/clinical-efficacy-of-a-two-year-oral-health-programme-for-infants-and-toddlers-in-singapore
#2
Bien Lai, Wee Kiat Tan, Qing Shu Lu
INTRODUCTION: Dental caries, which is prevalent in Singapore preschoolers, is a disease that has a major impact on children's health and places a high cost on the society and health services. Oral health programmes for young children implemented in several parts of the world have been shown to be effective in the prevention of dental caries. We aimed to examine the clinical efficacy of an oral health programme for infants and toddlers in Singapore. METHODS: 90 children and their caregivers participated in the programme while 64 children who were 24 months older than the intervention group at initial visit were recruited as controls in a quasi-experimental study design...
May 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28527374/talking-about-sunbed-tanning-social-representations-and-identity-work
#3
Jennifer Taylor, Michael Murray, Alexandra Lamont
RATIONALE: Despite the publicised health risks associated with its usage, sunbed tanning remains popular in many Western countries. Previous research indicates that knowledge of the harmful effects does not necessarily lead to a reduction in sunbed use. OBJECTIVE: The aim of this study was to develop a more extensive social psychological understanding of sunbed use, in the United Kingdom, by exploring the social representations of sunbed tanning held by both those who use and who have never used sunbeds...
May 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28522415/behavioural-adaptation-of-the-rice-leaf-folder-cnaphalocrocis-medinalis-to-short-term-heat-stress
#4
Muhammad Adnan Bodlah, Ling-Ling Gu, Ye Tan, Xiang-Dong Liu
Under ongoing climate warming, both the degree and number of high-temperature events in summer may increase, and behavioural adaptation is an important ecological strategy employed by insects to cope with such events. The rice leaf folder, Cnaphalocrocis medinalis Güenée, is a serious insect pest of rice fields in summer. Population outbreaks have become more frequent in the last ten years. In addition to adult migration, rice leaf folders are thought to have other thermal adaptations. Therefore, the behaviours of larval and adult rice leaf folders, such as leaf folding (making shelter) and habitat selection for pupae and eggs, were observed on rice plants under heat stress...
May 15, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28499079/development-of-an-atrophic-acne-scar-risk-assessment-tool
#5
J Tan, D Thiboutot, H Gollnick, S Kang, A Layton, J J Leyden, V Torres, J Guillemot, B Dréno
BACKGROUND: Acne is a chronic dermatological disease predominantly afflicting young adults and is often associated with the development of scars. Acne scarring is usually avoidable when acne is managed early and effectively. However, acne patients often fail to seek early treatment. New and innovative tools to raise awareness are needed. OBJECTIVE: This study presents the development and assessment of a tool aiming to assess the risk of atrophic acne scars. METHODS: A systematic literature review of clinical risk factors for acne scars, a Delphi-like survey of dermatological experts in acne and secondary data analysis were conducted in order to produce an evidence-based risk assessment tool...
May 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28481644/hidradenitis-suppurativa-intimate-partner-violence-and-sexual-assault
#6
Mia Sisic, Jerry Tan, Kathryn D Lafreniere
BACKGROUND: Sexual assault and intimate partner violence have never been examined in individuals with hidradenitis suppurativa. The research is important, because prior studies show higher incidences of intimate partner violence and sexual assault in individuals with disabilities, and hidradenitis suppurativa meets criteria for a disability. OBJECTIVES: The objective of the study is to examine whether individuals with hidradenitis suppurativa are at significantly higher risk of intimate partner violence and sexual assault compared with individuals who have acne, a recognised disability...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28473925/unintended-sunburn-a-potential-target-for-sun-protection-messages
#7
Geraldine F H McLeod, Anthony I Reeder, Andrew R Gray, Rob McGee
New Zealand (NZ) has the highest melanoma incidence rate in the world. Primary prevention efforts focus on reducing sunburn incidence and increasing sun protective practices in the population. However, sunburn from excessive ultraviolet radiation (UVR) remains common. To reduce sunburn incidence, it is important to examine those individuals who experience unintended sunburn. This study aims to use data from the NZ Triennial Sun Protection Survey to describe respondents who were not intending to tan but were sunburnt after outdoor UVR exposure...
2017: Journal of Skin Cancer
https://www.readbyqxmd.com/read/28462734/faster-eating-rates-are-associated-with-higher-energy-intakes-during-an-ad-libitum-meal-higher-bmi-and-greater-adiposity-among-4%C3%A2-5-year-old-children-results-from-the-growing-up-in-singapore-towards-healthy-outcomes-gusto-cohort
#8
Anna Fogel, Ai Ting Goh, Lisa R Fries, Suresh A Sadananthan, S Sendhil Velan, Navin Michael, Mya-Thway Tint, Marielle V Fortier, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary F F Chong, Ciarán G Forde
Faster eating rates are associated with increased energy intake, but little is known about the relationship between children's eating rate, food intake and adiposity. We examined whether children who eat faster consume more energy and whether this is associated with higher weight status and adiposity. We hypothesised that eating rate mediates the relationship between child weight and ad libitum energy intake. Children (n 386) from the Growing Up in Singapore Towards Healthy Outcomes cohort participated in a video-recorded ad libitum lunch at 4·5 years to measure acute energy intake...
May 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28407804/mathematical-model-of-tgf-%C3%AE-signalling-feedback-coupling-is-consistent-with-signal-switching
#9
Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess
BACKGROUND: Transforming growth factor β (TGF-β) signalling regulates the development of embryos and tissue homeostasis in adults. In conjunction with other oncogenic changes, long-term perturbation of TGF-β signalling is associated with cancer metastasis. Although TGF-β signalling can be complex, many of the signalling components are well defined, so it is possible to develop mathematical models of TGF-β signalling using reduction and scaling methods. The parameterization of our TGF-β signalling model is consistent with experimental data...
April 13, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28369044/high-electron-mobility-and-quantum-oscillations-in-non-encapsulated-ultrathin-semiconducting-bi2o2se
#10
Jinxiong Wu, Hongtao Yuan, Mengmeng Meng, Cheng Chen, Yan Sun, Zhuoyu Chen, Wenhui Dang, Congwei Tan, Yujing Liu, Jianbo Yin, Yubing Zhou, Shaoyun Huang, H Q Xu, Yi Cui, Harold Y Hwang, Zhongfan Liu, Yulin Chen, Binghai Yan, Hailin Peng
High-mobility semiconducting ultrathin films form the basis of modern electronics, and may lead to the scalable fabrication of highly performing devices. Because the ultrathin limit cannot be reached for traditional semiconductors, identifying new two-dimensional materials with both high carrier mobility and a large electronic bandgap is a pivotal goal of fundamental research. However, air-stable ultrathin semiconducting materials with superior performances remain elusive at present. Here, we report ultrathin films of non-encapsulated layered Bi2O2Se, grown by chemical vapour deposition, which demonstrate excellent air stability and high-mobility semiconducting behaviour...
April 3, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28367970/effective-hamiltonian-for-surface-states-of-topological-insulator-nanotubes
#11
Zhuo Bin Siu, Seng Ghee Tan, Mansoor B A Jalil
In this work we derive an effective Hamiltonian for the surface states of a hollow topological insulator (TI) nanotube with finite width walls. Unlike a solid TI cylinder, a TI nanotube possesses both an inner as well as outer surface on which the states localized at each surface are coupled together. The curvature along the circumference of the nanotube leads to a spatial variation of the spin orbit interaction field experienced by the charge carriers as well as an asymmetry between the inner and outer surfaces of the nanotube...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28361990/a-retinoraphe-projection-regulates-serotonergic-activity-and-looming-evoked-defensive-behaviour
#12
Lu Huang, Tifei Yuan, Minjie Tan, Yue Xi, Yu Hu, Qian Tao, Zhikai Zhao, Jiajun Zheng, Yushui Han, Fuqiang Xu, Minmin Luo, Patricia J Sollars, Mingliang Pu, Gary E Pickard, Kwok-Fai So, Chaoran Ren
Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behaviour remain unclear. Here we identify a subset of retinal ganglion cells (RGCs) that controls mouse looming-evoked defensive responses through axonal collaterals to the dorsal raphe nucleus (DRN) and SC...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28335258/nanostructures-derived-from-starch-and-chitosan-for-fluorescence-bio-imaging
#13
Yinxue Zu, Jingran Bi, Huiping Yan, Haitao Wang, Yukun Song, Bei-Wei Zhu, Mingqian Tan
Fluorescent nanostructures (NSs) derived from polysaccharides have drawn great attention as novel fluorescent probes for potential bio-imaging applications. Herein, we reported a facile alkali-assisted hydrothermal method to fabricate polysaccharide NSs using starch and chitosan as raw materials. Transmission electron microscopy (TEM) demonstrated that the average particle sizes are 14 nm and 75 nm for starch and chitosan NSs, respectively. Fourier transform infrared (FT-IR) spectroscopy analysis showed that there are a large number of hydroxyl or amino groups on the surface of these polysaccharide-based NSs...
July 5, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334947/protocadherin-19-pcdh19-interacts-with-paraspeckle-protein-nono-to-co-regulate-gene-expression-with-estrogen-receptor-alpha-er%C3%AE
#14
Duyen H Pham, Chuan C Tan, Claire C Homan, Kristy L Kolc, Mark A Corbett, Dale McAninch, Archa H Fox, Paul Q Thomas, Raman Kumar, Jozef Gecz
De novo and inherited mutations of X-chromosome cell adhesion molecule protocadherin 19 (PCDH19) cause frequent, highly variable epilepsy, autism, cognitive decline and behavioural problems syndrome. Intriguingly, hemizygous null males are not affected while heterozygous females are, contradicting established X-chromosome inheritance. The disease mechanism is not known. Cellular mosaicism is the likely driver. We have identified p54nrb/NONO, a multifunctional nuclear paraspeckle protein with known roles in nuclear hormone receptor gene regulation, as a PCDH19 protein interacting partner...
June 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28317138/impact-of-providing-psychiatry-specialty-pharmacist-intervention-on-reducing-drug-related-problems-among-children-with-autism-spectrum-disorder-related-to-disruptive-behavioural-symptoms-a-prospective-randomized-open-label-study
#15
R Wongpakaran, T Suansanae, T Tan-Khum, C Kraivichian, R Ongarjsakulman, C Suthisisang
WHAT IS KNOWN AND OBJECTIVES: Psychopharmacologic therapy has so far focused on ameliorating disruptive behaviours to improve patient's function and quality of life. Due to the complicated neurobiological aetiology of autism spectrum disorder (ASD), a traditional pharmacist intervention may be insufficient to initiate the optimal care for this vulnerable population. We evaluate the impact of providing specialty psychiatry (PS) pharmacist intervention in identifying and resolving drug-related problems (DRPs) among children with ASD associated with disruptive behaviours...
March 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28289050/knowledge-and-attitudes-of-uk-university-students-in-relation-to-ultraviolet-radiation-uvr-exposure-and-their-sun-related-behaviours-a-qualitative-study
#16
Lucy Kirk, Sheila Greenfield
OBJECTIVES: To explore whether knowledge about the harms of ultraviolet radiation (UVR) influences UK university students' sun-related behaviours and examine in depth their attitudes towards: sun protection, natural and artificial tanning behaviours. DESIGN: Qualitative methodology with 15 semistructured, individual interviews. Thematic analysis using the Framework Method with analyst triangulation and member validation. SETTING: One university in the West Midlands, UK...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28274459/rheological-properties-of-polysaccharides-from-dioscorea-opposita-thunb
#17
Fanyi Ma, Yun Zhang, Nanhua Liu, Jie Zhang, Gaixiu Tan, Balan Kannan, Xiuhua Liu, Alan E Bell
This study investigated the chemical components and rheological properties of polysaccharides from Dioscorea opposita Thunb. Graded alcohol precipitation was used to extract Dioscorea opposita polysaccharide samples (S1, S2, S3 and S4). The monosaccharides, amino acid content and molecular weight of each sample were measured and compared. The rheological properties of the polysaccharide samples at different concentrations, temperatures and pH values were studied. The rheological properties of S1, S2 and S3 exhibited pseudoplastic properties and "gel-like" behaviour...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28250942/curved-crystal-morphology-photoreactivity-and-photosalient-behaviour-of-mononuclear-zn-ii-complexes
#18
Caroline Evania Mulijanto, Hong Sheng Quah, Geok Kheng Tan, Bruno Donnadieu, Jagadese J Vittal
A dramatic effect of crystal morphology, photoreactivity and photosalient property is observed in a zinc(II) complex due to solvent effects and fluorine substitution at the backbone of the ligand. Of the two crystal forms with a 3-fluoro derivative, one yielded a curved morphology of single crystals and the second form shows photoreactivity in the solid state, whereas crystals of the 2-fluoro derivative pop during the [2 + 2] photocycloaddition reaction. This is the first report documenting curved single crystals of metal complexes obtained naturally during crystallization, although such bent crystals have been observed in extended solids naturally, or bent by mechanical force or by UV irradiation...
January 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28219347/aquaculture-genomics-genetics-and-breeding-in-the-united-states-current-status-challenges-and-priorities-for-future-research
#19
EDITORIAL
Hisham Abdelrahman, Mohamed ElHady, Acacia Alcivar-Warren, Standish Allen, Rafet Al-Tobasei, Lisui Bao, Ben Beck, Harvey Blackburn, Brian Bosworth, John Buchanan, Jesse Chappell, William Daniels, Sheng Dong, Rex Dunham, Evan Durland, Ahmed Elaswad, Marta Gomez-Chiarri, Kamal Gosh, Ximing Guo, Perry Hackett, Terry Hanson, Dennis Hedgecock, Tiffany Howard, Leigh Holland, Molly Jackson, Yulin Jin, Karim Kahlil, Thomas Kocher, Tim Leeds, Ning Li, Lauren Lindsey, Shikai Liu, Zhanjiang Liu, Kyle Martin, Romi Novriadi, Ramjie Odin, Yniv Palti, Eric Peatman, Dina Proestou, Guyu Qin, Benjamin Reading, Caird Rexroad, Steven Roberts, Mohamed Salem, Andrew Severin, Huitong Shi, Craig Shoemaker, Sheila Stiles, Suxu Tan, Kathy F J Tang, Wilawan Thongda, Terrence Tiersch, Joseph Tomasso, Wendy Tri Prabowo, Roger Vallejo, Hein van der Steen, Khoi Vo, Geoff Waldbieser, Hanping Wang, Xiaozhu Wang, Jianhai Xiang, Yujia Yang, Roger Yant, Zihao Yuan, Qifan Zeng, Tao Zhou
Advancing the production efficiency and profitability of aquaculture is dependent upon the ability to utilize a diverse array of genetic resources. The ultimate goals of aquaculture genomics, genetics and breeding research are to enhance aquaculture production efficiency, sustainability, product quality, and profitability in support of the commercial sector and for the benefit of consumers. In order to achieve these goals, it is important to understand the genomic structure and organization of aquaculture species, and their genomic and phenomic variations, as well as the genetic basis of traits and their interrelationships...
February 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28213204/a-description-of-an-obesogenic-eating-style-that-promotes-higher-energy-intake-and-is-associated-with-greater-adiposity-in-4-5year-old-children-results-from-the-gusto-cohort
#20
Anna Fogel, Ai Ting Goh, Lisa R Fries, Suresh Anand Sadananthan, S Sendhil Velan, Navin Michael, Mya Thway Tint, Marielle Valerie Fortier, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P Shek, Michael J Meaney, Birit F P Broekman, Yung Seng Lee, Keith M Godfrey, Mary Foong Fong Chong, Ciarán G Forde
Recent findings confirm that faster eating rates support higher energy intakes within a meal and are associated with increased body weight and adiposity in children. The current study sought to identify the eating behaviours that underpin faster eating rates and energy intake in children, and to investigate their variations by weight status and other individual differences. Children (N=386) from the Growing Up in Singapore towards Healthy Outcomes (GUSTO) cohort took part in a video-recorded ad libitum lunch at 4...
July 1, 2017: Physiology & Behavior
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