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https://www.readbyqxmd.com/read/28068861/a-reformative-shear-precipitation-procedure-for-the-fabrication-of-vancomycin-loaded-poly-lactide-co-glycolide-microspheres
#1
Lei Wang, Qinmeng Yang, Yirong Chen, Yu Chai, Jiao Jiao Li, Lin Du, Ruizhe Tan, Shenyu Yang, Mei Tu, Bin Yu
This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using a novel reformative shear precipitation procedure. In contrast to the external aqueous phase used in the conventional microencapsulation technique based on emulsion solvent evaporation/extraction, the reformative shear precipitation procedure explored in this study uses a shear medium composed of glycerol as the viscous medium and ethanol as polymer antisolvent, which is relatively immiscible with the hydrophilic drug...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28065929/standardized-static-and-dynamic-evaluation-of-myocardial-tissue-properties
#2
Sherif Ramadan, Narinder Paul, Hani E Naguib
INTRODUCTION: Quantifying the mechanical behaviours of soft biological tissues is of considerable research interest. However, validity and reproducibility between different researchers and apparatus is questionable. This study aims to quantify the mechanical properties of myocardium while investigating methodologies that can standardize biological tissue testing. MATERIALS AND METHODS: Tensile testing was performed to obtain Young���s modulus and a dynamic mechanical analysis (DMA) determined the viscoelastic properties...
January 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28058507/als-ftld-experimental-models-and-reality
#3
REVIEW
Rachel H Tan, Yazi D Ke, Lars M Ittner, Glenda M Halliday
Amyotrophic lateral sclerosis is characterised by a loss of upper and lower motor neurons and characteristic muscle weakness and wasting, the most common form being sporadic disease with neuronal inclusions containing the tar DNA-binding protein 43 (TDP-43). Frontotemporal lobar degeneration is characterised by atrophy of the frontal and/or temporal lobes, the most common clinical form being the behavioural variant, in which neuronal inclusions containing either TDP-43 or 3-repeat tau are most prevalent. Although the genetic mutations associated with these diseases have allowed various experimental models to be developed, the initial genetic forms identified remain the most common models employed to date...
January 5, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28055000/personalising-care-of-adults-with-asthma-from-asia-a-modified-e-dephi-consensus-study-to-inform-management-tailored-to-attitude-and-control-profiles
#4
Alison Chisholm, David B Price, Hilary Pinnock, Tan Tze Lee, Camilo Roa, Sang-Heon Cho, Aileen David-Wang, Gary Wong, Thys van der Molen, Dermot Ryan, Nina Castillo-Carandang, Yee Vern Yong
REALISE Asia-an online questionnaire-based study of Asian asthma patients-identified five patient clusters defined in terms of their control status and attitude towards their asthma (categorised as: 'Well-adjusted and at least partly controlled'; 'In denial about symptoms'; 'Tolerating with poor control'; 'Adrift and poorly controlled'; 'Worried with multiple symptoms'). We developed consensus recommendations for tailoring management of these attitudinal-control clusters. An expert panel undertook a three-round electronic Delphi (e-Delphi): Round 1: panellists received descriptions of the attitudinal-control clusters and provided free text recommendations for their assessment and management...
January 5, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28042358/building-intentions-with-the-theory-of-planned-behaviour-the-mediating-role-of-knowledge-and-expectations-in-implementing-new-pharmaceutical-services-in-malaysia
#5
Christine L Tan, Vincent B Gan, Fahad Saleem, Mohamed A Hassali
BACKGROUND: Pharmacy value added services (PVAS) was introduced as a matter of public health policy by Malaysia's Ministry of Health to improve health outcomes through public healthcare services. For example, drive through pharmacy services is a major policy implementation of the Ministry. However, adoption rates are low and therefore hampering the achievement of national health policy goals. OBJECTIVE: Our objective is to explore the key determinants and mediators of successful implementation of new public pharmaceutical services by investigating the cognitive perspectives of patients' intentions to adopt with the Theory of Planned Behavior as the theoretical framework...
October 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/28040906/the-method-of-pulsed-x-ray-detection-with-a-diode-laser
#6
Jun Liu, Xiaoping Ouyang, Zhongbing Zhang, Liang Sheng, Liang Chen, Xinjian Tan, Xiufeng Weng
A new class of pulsed X-ray detection methods by sensing carrier changes in a diode laser cavity has been presented and demonstrated. The proof-of-principle experiments on detecting pulsed X-ray temporal profile have been done through the diode laser with a multiple quantum well active layer. The result shows that our method can achieve the aim of detecting the temporal profile of a pulsed X-ray source. We predict that there is a minimum value for the pre-bias current of the diode laser by analyzing the carrier rate equation, which exists near the threshold current of the diode laser chip in experiments...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27987316/telangiectasia-of-the-face-risk-factors-for-reappearance-in-patients-treated-with-dye-laser
#7
S Guida, M G Galimberti, M Bencini, G Pellacani, P L Bencini
BACKGROUND: Lasers can be successfully used in the treatment of facial telangiectases. Nevertheless, reappearance of telangiectasias after successful laser treatment is a significant problem. Risk factors involved in the reappearance have not been previously investigated. OBJECTIVE: To evaluate whether personal, clinical and behavioural factors can influence the recurrence or new appearance of telangiectasias after treatment. METHODS: 415 women and 69 men obtaining complete clearance after laser treatment were included in the study and the role of different risk factors in the reappearance of telangiectasias was analyzed...
December 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27974549/tsc1-2-mutations-define-a-molecular-subset-of-hcc-with-aggressive-behaviour-and-treatment-implication
#8
Daniel W H Ho, Lo K Chan, Yung T Chiu, Iris M J Xu, Ronnie T P Poon, Tan T Cheung, Chung N Tang, Victor W L Tang, Irene L O Lo, Polly W Y Lam, Derek T W Yau, Miao X Li, Chun M Wong, Irene O L Ng
OBJECTIVE: We investigated the mutational landscape of mammalian target of rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, aiming to evaluate and delineate mutation-dependent mechanism of mTOR hyperactivation in hepatocarcinogenesis. DESIGN: We performed next-generation sequencing on human HCC samples and cell line panel. Systematic mutational screening of mTOR pathway-related genes was undertaken and mutant genes were evaluated based on their recurrence...
December 14, 2016: Gut
https://www.readbyqxmd.com/read/27972820/building-intentions-with-the-theory-of-planned-behaviour-the-mediating-role-of-knowledge-and-expectations-in-implementing-new-pharmaceutical-services-in-malaysia
#9
C L Tan, V B Gan, F Saleem, M A Hassali
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27951434/neutrophil-migration-in-inflammation-intercellular-signal-relay-and-crosstalk
#10
REVIEW
Sioh-Yang Tan, Wolfgang Weninger
Neutrophils are innate effector cells armed with a potent machinery to combat damage and infection within tissues. Their ability to rapidly respond to danger signals and mobilise is crucial to their role. After extravasation, neutrophil populations often exhibit swarming behaviour. Swarming occurs in distinct phases and is coordinated via inter-neutrophil signal relay in the form of small molecule mediators. Neutrophils also engage in multi-dimensional crosstalk with tissue-resident cells and incoming leukocytes in the inflammatory milieu...
December 9, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27915998/an-update-on-semantic-dementia-genetics-imaging-and-pathology
#11
REVIEW
Ramon Landin-Romero, Rachel Tan, John R Hodges, Fiona Kumfor
Progressive and relatively circumscribed loss of semantic knowledge, referred to as semantic dementia (SD) which falls under the broader umbrella of frontotemporal dementia, was officially identified as a clinical syndrome less than 50 years ago. Here, we review recent neuroimaging, pathological, and genetic research in SD. From a neuroimaging perspective, SD is characterised by hallmark asymmetrical atrophy of the anterior temporal pole and anterior fusiform gyrus, which is usually left lateralised. Functional magnetic resonance imaging (fMRI) studies have revealed widespread changes in connectivity, implicating the anterior temporal regions in semantic deficits in SD...
December 5, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27881937/-better-do-not-touch-and-other-superstitions-concerning-melanoma-the-cross-sectional-web-based-survey
#12
Maksymilian Gajda, Grażyna Kamińska-Winciorek, Jerzy Wydmański, Andrzej Tukiendorf
INTRODUCTION: To the authors' best knowledge, there are no data regarding the prevalence of superstitions concerning melanoma among internet users. AIM: To evaluate the prevalence and identify reasons for superstitions associated with excision of pigmented skin lesions as well as to assess the frequency of this procedure. MATERIAL AND METHODS: Readers of the scientific portal were invited to complete a fully anonymous e-questionnaire. After collection of questionnaires (5,154) and eliminating incomplete ones, 4,919 surveys were analysed...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27878887/why-do-young-adults-tan
#13
LETTER
C L Thomas, P Fernandez Peñas
No abstract text is available yet for this article.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27878788/sun-protective-behaviour-and-sunburn-prevalence-in-primary-and-secondary-schoolchildren-in-western-switzerland
#14
Simone Ackermann, Anne Vuadens, Fabio Levi, Jean-Luc Bulliard
AIMS OF THE STUDY: Although solar overexposure during childhood and adolescence increases the risk of melanoma, determinants of sunburn and sun protective behaviours of Swiss children have scarcely been explored. We investigated sunburn occurrence and sun protective behaviours of schoolchildren in western Switzerland, the region with the highest incidence of melanoma in Europe. MATERIAL AND METHODS: Self-reported questionnaires were administered during regular classes to pupils in 5th (primary school, n = 431), 8th and 11th grades (secondary school, n = 837) in the 18 public schools of La Chaux-de-Fonds...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27845887/a-review-of-heavy-metals-in-indoor-dust-and-its-human-health-risk-implications
#15
Sock Yin Tan, Sarva Mangala Praveena, Emilia Zainal Abidin, Manraj Singh Cheema
Indoor dust acts as a media for heavy metal deposition. Past studies have shown that heavy metal concentration in indoor dust is affected by local human activities and atmospheric transport can have harmful effects on human health. Additionally, children are more sensitive to heavy metals due to their hand-to-mouth behaviour and rapid body development. However, limited information on health risks were found in past dust studies as these studies aimed to identify heavy metal concentrations and sources of indoor dust...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27798017/desensitisation-to-cigarette-package-graphic-health-warnings-a-cohort-comparison-between-london-and-singapore
#16
Culadeeban Ratneswaran, Ben Chisnall, Mingyue Li, Sarah Tan, Abdel Douiri, Devanand Anantham, Joerg Steier
OBJECTIVES: We compared 2 sociocultural cohorts with different duration of exposure to graphic health warning labels (GHWL), to investigate a possible desensitisation to their use. We further studied how a differing awareness and emotional impact of smoking-associated risks could be used to prevent this. SETTING: Structured interviews of patients from the general respiratory department were undertaken between 2012 and 2013 in 2 tertiary hospitals in Singapore and London...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27759051/gas-protection-of-two-dimensional-nanomaterials-from-high-energy-impacts
#17
Tan Xing, Srikanth Mateti, Lu Hua Li, Fengxian Ma, Aijun Du, Yury Gogotsi, Ying Chen
Two-dimensional (2D) materials can be produced using ball milling with the help of liquid surfactants or solid exfoliation agents, as ball milling of bulk precursor materials usually produces nanosized particles because of high-energy impacts. Post-milling treatment is thus needed to purify the nanosheets. We show here that nanosheets of graphene, BN, and MoS2 can be produced by ball milling of their bulk crystals in the presence of ammonia or a hydrocarbon ethylene gas and the obtained nanosheets remain flat and maintain their single-crystalline structure with low defects density even after a long period of time; post-milling treatment is not needed...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27750011/endogenous-polysialic-acid-based-micelles-for-calmodulin-antagonist-delivery-against-vascular-dementia
#18
Xiao-Juan Wang, Yin-Ping Gao, Nan-Nan Lu, Wei-Shuo Li, Ji-Fang Xu, Xiao-Ying Ying, Gang Wu, Mei-Hua Liao, Chao Tan, Ling-Xiao Shao, Ying-Mei Lu, Chen Zhang, Kohji Fukunaga, Feng Han, Yong-Zhong Du
Clinical treatment for vascular dementia still remains a challenge mainly due to the blood-brain barrier (BBB). Here, a micelle based on polysialic acid (PSA), which is a hydrophilic and endogenous carbohydrate polymer, was designed to deliver calmodulin antagonist for therapy of vascular dementia. PSA was first chemically conjugated with octadecylamine (ODA), and the obtained PSA-ODA copolymer could self-assemble into micelle in aqueous solution with a 120.0 μg/mL critical micelle concentration. The calmodulin antagonist loaded PSA-ODA micelle, featuring sustained drug release behavior over a period of 72 h with a 3...
December 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27749495/sun-related-knowledge-and-attitudes-of-primary-and-secondary-schoolchildren-in-western-switzerland
#19
Anne Vuadens, Simone Ackermann, Fabio Levi, Jean-Luc Bulliard
Switzerland, particularly its western region, has the highest incidence of melanoma in Europe. Although the risk of melanoma increases with sun overexposure during childhood, sun-related knowledge and attitudes of Swiss children are scarcely documented. We report the first investigation of the knowledge of the danger of ultraviolet radiation, attitudes towards a suntan and parental influence of schoolchildren in western Switzerland. All fifth, eighth and eleventh graders (average ages of 9, 12 and 15, respectively) in the 18 primary (fifth grade, n=431) and secondary (eighth and eleventh grades, n=837) public schools of La Chaux-de-Fonds were surveyed during regular school classes...
October 5, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27713665/the-interactive-bending-wrinkling-behaviour-of-inflated-beams
#20
Y P Liu, C G Wang, H F Tan, M K Wadee
A model is proposed based on a Fourier series method to analyse the interactive bending wrinkling behaviour of inflated beams. The whole wrinkling evolution is tracked and divided into three stages by identifying the bifurcations of the equilibrium path. The critical wrinkling and failure moments of the inflated beam can then be predicted. The global-local interactive buckling pattern is elucidated by the proposed theoretical model and also verified by non-contact experimental tests. The effects of geometric parameters, internal pressure and boundary conditions on the buckling of inflated beams are investigated finally...
September 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
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