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https://www.readbyqxmd.com/read/28938577/mitochondria-chaperone-grp75-moonlighting-as-a-cell-cycle-controller-to-derail-endocytosis-provides-an-opportunity-for-nanomicrosphere-intracellular-delivery
#1
Zhihui Gao, Xiuran Niu, Qing Zhang, Hang Chen, Aiai Gao, Shanshan Qi, Rong Xiang, Mattias Belting, Sihe Zhang
Understanding how cancer cells regulate endocytosis during the cell cycle could lead us to capitalize this event pharmacologically. Although certain endocytosis pathways are attenuated during mitosis, the endocytosis shift and regulation during the cell cycle have not been well clarified. The conventional concept of glucose-regulated proteins (GRPs) as protein folding chaperones was updated by discoveries that translocated GRPs assume moonlighting functions that modify the immune response, regulate viral release, and control intracellular trafficking...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938105/how-people-from-ethnic-minorities-describe-their-experiences-of-managing-type-2-diabetes-mellitus-a-qualitative-meta-synthesis
#2
REVIEW
Virginia Jones, Marie Crowe
BACKGROUND: The increasing prevalence of diabetes is well-documented along with the findings that some ethnic minorities have a higher prevalence than non-minority individuals. Along with possible biological differences between ethnicities, access to economic, social, cultural and symbolic capital may impact on the success of managing type-2 diabetes. OBJECTIVES: To examine how people from ethnic minorities in Western countries describe their experiences of managing type-2 diabetes mellitus...
August 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28938088/small-molecule-inhibitors-targeting-dna-repair-and-dna-repair-deficiency-in-research-and-cancer-therapy
#3
REVIEW
Sarah R Hengel, M Ashley Spies, Maria Spies
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude of deleterious DNA lesions, which arise constantly in every cell. Processes that support genome integrity in normal cells, however, allow cancer cells to develop resistance to radiation and DNA-damaging chemotherapeutics. Chemical inhibition of the key DNA repair proteins and pharmacologically induced synthetic lethality have become instrumental in both dissecting the complex DNA repair networks and as promising anticancer agents...
September 21, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28936952/-application-of-injection-test-in-confirming-the-ideal-position-of-esophageal-balloon-catheter
#4
Han Chen, Ming Xu, Yanlin Yang, Xuan He, Jianxin Zhou
OBJECTIVE: To evaluate the safety and feasibility of injection test which is used to locate esophageal balloon catheter. METHODS: A prospective study was conducted. The patients undergoing invasive mechanical ventilation (MV) admitted to general intensive care unit (ICU) of Beijing Tiantan Hospital Affiliated to Capital Medical University from May 2015 and March 2017 were enrolled. The commercially available esophageal balloon catheter was modified to perform injection test...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936225/human-capital-theory-and-internal-migration-do-average-outcomes-distort-our-view-of-migrant-motives
#5
Martin Korpi, William A W Clark
By modelling the distribution of percentage income gains for movers in Sweden, using multinomial logistic regression, this paper shows that those receiving large pecuniary returns from migration are primarily those moving to the larger metropolitan areas and those with higher education, and that there is much more variability in income gains than what is often assumed in models of average gains to migration. This suggests that human capital models of internal migration often overemphasize the job and income motive for moving, and fail to explore where and when human capital motivated migration occurs...
May 2017: Migration Letters
https://www.readbyqxmd.com/read/28935433/intersectorality-and-social-participation-as-coping-policies-for-health-inequities-worldwide
#6
Regina Celia Fiorati, Ricardo A Arcêncio, Javier Segura Del Pozo, Milagros Ramasco-Gutiérrez, Pilar Serrano-Gallardo
OBJECTIVE: To determine the impact that intersectoral policies and social participation, implemented worldwide, have had on the modification of the social determinants for health and on the reduction of social health inequities. METHOD: A scoping review of the literature published in the period 2005-2015 was performed. The literature search was conducted on PubMed and Scielo databases. Two researchers reviewed each document. Data were analysed according to the intersectoral action and social participation variables and according to the theoretical frameworks of the Social Determinants Model of the Commission on Social Determinants of Health (CSDH) and the theoretical constructs of Social Capital (SC) and Life Course (LC)...
September 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28934900/societal-costs-and-effects-of-implementing-population-based-mammography-screening-in-greenland
#7
Maria Klitgaard Christensen, Birgit V Niclasen, Kim Moesgaard Iburg
With a low breast cancer incidence and low population density, Greenland is geographically and organisationally challenged in implementing a cost effective breast cancer screening programme where a large proportion of the Greenlandic women will have to travel far to attend. The aim of this paper is to evaluate the cost effectiveness and cost utility of different strategies for implementing population-based breast cancer screening in Greenland. Two strategies were evaluated: Centralised screening in the capital Nuuk and decentralised screening in the five municipal regions of Greenland...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28934282/assessing-ecosystem-service-provision-under-climate-change-to-support-conservation-and-development-planning-in-myanmar
#8
Lisa Mandle, Stacie Wolny, Nirmal Bhagabati, Hanna Helsingen, Perrine Hamel, Ryan Bartlett, Adam Dixon, Radley Horton, Corey Lesk, Danielle Manley, Manishka De Mel, Daniel Bader, Sai Nay Won Myint, Win Myint, Myat Su Mon
Inclusion of ecosystem services (ES) information into national-scale development and climate adaptation planning has yet to become common practice, despite demand from decision makers. Identifying where ES originate and to whom the benefits flow-under current and future climate conditions-is especially critical in rapidly developing countries, where the risk of ES loss is high. Here, using Myanmar as a case study, we assess where and how ecosystems provide key benefits to the country's people and infrastructure...
2017: PloS One
https://www.readbyqxmd.com/read/28932822/efl-reading-goals-of-grade-11-students-across-public-and-non-public-schools-in-addis-ababa-ethiopia
#9
Tekle Ferede, B M Nchindila
This study investigated the EFL reading goals of Grade 11 students across public and non-public schools in the Ethiopian capital, Addis Ababa. To this end, quantitative data were collected from 556 (375 public and 181 non-public) students via pre-tested structured questionnaire and analyzed into means, medians, standard deviations, ranges and Mann-Whitney U test scores. The results show that non-public school students were found better than public school students in possessing components of both extrinsic and intrinsic goals for reading...
September 2017: Heliyon
https://www.readbyqxmd.com/read/28929855/the-patients-as-partners-movement-and-the-emerging-health-leader
#10
Melinda Young
Over the past decade, the Patients as Partners Movement has spread throughout healthcare systems across Canada. This movement aims to overcome the paternalistic approach, where the system and its providers act for or deliver services to the patient. Instead, decision-making at all levels is to be shared with the patient. Delivering patient- and family-centred care is the goal of the Patients as Partners Movement and authentic engagement is at its core. This article aims to explore the link between the Patients as Partners Movement and authentic engagement...
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929853/physician-leadership-development-evidence-informed-design-tempered-with-real-life-experience
#11
Shawn Jolemore, Steven D Soroka
This article describes key considerations for creation of evidence-informed in-house physician leadership development. Ten elements extracted from a scan of the peer-reviewed and grey literature are presented, and key learnings at the Queen Elizabeth II Health Sciences Centre, a quaternary academic health sciences centre in Halifax, Nova Scotia, are highlighted. Each element is briefly described with practical considerations and challenges to implementation outlined in the context of the former Capital District Health Authority, where the authors collaborated to create in-house physician leadership development prior to the consolidation of health districts in that province...
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929479/social-capital-neighborhood-disorder-and-disaster-recovery
#12
Lauren Clay, Mia Papas, David Abramson, James Kendra
OBJECTIVE: This study examined social institutions as a contextual factor that may influence perceptions of neighborhood physical and social disorder during disaster recovery. DESIGN: The study used descriptive statistics and fit logistic regression models. SETTING AND PARTICIPANTS: Participants in this study (n = 772) were recruited from temporary housing in Louisiana and Mississippi as part of the Gulf Coast Child and Family Health Study, a longitudinal study of households heavily impacted by Hurricane Katrina...
July 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28926739/electrophysiological-correlates-of-performance-monitoring-in-binge-drinking-impaired-error-related-but-preserved-feedback-processing
#13
Séverine Lannoy, Fabien D'Hondt, Valérie Dormal, Joël Billieux, Pierre Maurage
OBJECTIVE: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of risky behaviors, the present study aimed at determining the behavioral and electrophysiological correlates of the cognitive (inhibition) and motivational (reward sensitivity) systems during performance monitoring...
September 2, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28924350/pharmacovigilance-and-adverse-drug-reaction-reporting-a-perspective-of-community-pharmacists-and-pharmacy-technicians-in-sana-a-yemen
#14
Yaser Mohammed Al-Worafi, Yaman Walid Kassab, Wafa Mohammed Alseragi, Masaad Saeed Almutairi, Ali Ahmed, Long Chiau Ming, Ali Saleh Alkhoshaiban, Muhammad Abdul Hadi
OBJECTIVE: The aim of this study was to compare the knowledge, attitude and barriers of pharmacy technicians and pharmacists toward pharmacovigilance, adverse drug reactions (ADRs) and ADR reporting in community pharmacies in Yemen. METHODS: This cross-sectional survey was conducted among community pharmacists and pharmacy technicians in the capital of Yemen, Sana'a. A total of 289 community pharmacies were randomly selected. The validated and pilot-tested questionnaire consisted of six sections: demographic data, knowledge about pharmacovigilance, experience with ADR reporting, attitudes toward ADR reporting, and the facilitators to improve ADR reporting...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28924311/performance-of-indian-diabetes-risk-score-idrs-as-screening-tool-for-diabetes-in-an-urban-slum
#15
Puja Dudeja, Gurpreet Singh, Tukaram Gadekar, Sandip Mukherji
BACKGROUND: India is diabetic capital of world, with maximum number of diabetic patients. There is large burden of undetected diabetic cases in community. There is increasing risk of diabetes in urban slum, because of illiteracy, lack of awareness, low socioeconomic status and unhealthy life style. Madras Diabetes Research Foundation (MDRF) has developed Indian Diabetes Risk Score (IDRS) to detect undiagnosed Type 2 diabetes. The aim of this article is to study the performance of IDRS as screening tool for undiagnosed cases of Type 2 diabetes and to find the prevalence of undiagnosed Type 2 diabetes in an urban slum...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28924181/common-and-dissociable-regional-cerebral-blood-flow-differences-associate-with-dimensions-of-psychopathology-across-categorical-diagnoses
#16
A N Kaczkurkin, T M Moore, M E Calkins, R Ciric, J A Detre, M A Elliott, E B Foa, A Garcia de la Garza, D R Roalf, A Rosen, K Ruparel, R T Shinohara, C H Xia, D H Wolf, R E Gur, R C Gur, T D Satterthwaite
The high comorbidity among neuropsychiatric disorders suggests a possible common neurobiological phenotype. Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neuropsychiatric disorders. Regional CBF may also provide a useful biological marker across different types of psychopathology. To investigate CBF changes common across psychiatric disorders, we capitalized upon a sample of 1042 youths (ages 11-23 years) who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28923460/the-mortality-burden-of-hourly-temperature-variability-in-five-capital-cities-australia-time-series-and-meta-regression-analysis
#17
Jian Cheng, Zhiwei Xu, Hilary Bambrick, Hong Su, Shilu Tong, Wenbiao Hu
BACKGROUND: Unstable weather, such as intra- and inter-day temperature variability, can impair the health and shorten the survival time of population around the world. Climate change will cause Earth's surface temperature rise, but has unclear effects on temperature variability, making it urgent to understand the characteristics of the burden of temperature variability on mortality, regionally and nationally. OBJECTIVES: This paper aims to quantify the mortality risk of exposure to short-term temperature variability, estimate the resulting death toll and explore how the strength of temperature variability effects will vary as a function of city-level characteristics...
September 15, 2017: Environment International
https://www.readbyqxmd.com/read/28923339/-tobacco-use-in-brazilian-school-adolescents-association-with-mental-health-and-family-context
#18
Camila Zander Neves, Claudine Devicari Bueno, Giovana Pires Felden, Mariane Costa Irigaray, María Fernanda Rivadeneira, Nágila Oenning, Bárbara Niegia Garcia de Goulart
OBJECTIVE: To study the association between aspects of mental health and the family context with tobacco experimentation and consumption among Brazilian schoolchildren. METHOD: A cross-sectional study using data from the National Survey of Schoolchildren's Health in Brazil conducted on 109,104 schoolchildren from the ninth year of elementary school, day scholars in public and private schools in all Brazilian state capitals and the Federal District. Descriptive analysis of variables, bivariate and multivariate analyses were performed with logistic regression estimates, adjusted for socioeconomic variables, obtaining the odds ratio (OR) and 95% confidence interval (95%CI)...
September 15, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28923047/prepubertal-onset-of-slipped-capital-femoral-epiphysis-associated-with-hypothyroidism-a-case-report-and-literature-review
#19
Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi, Toshiyuki Fukao
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. CASE PRESENTATION: The patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism...
September 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28922820/justifying-british-advertising-in-war-and-austerity-1939-51
#20
Philippa Haughton
Drawing together institutional papers, the trade- and national-press, and Mass-Observation documents, this article examines the changing ways that the Advertising Association justified commercial advertising from 1939 to 1951. It argues that the ability to repeatedly re-conceptualize the social and economic purposes of advertising was central to the industry's survival and revival during the years of war and austerity. This matters because the survival and revival of commercial advertising helps to explain the composition of the post-war mixed economy and the emergence of a consumer culture that became the 'golden age' of capitalism...
September 1, 2017: 20 Century British History
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