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Pesticides chronic kidney disease

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https://www.readbyqxmd.com/read/26403530/agricultural-pesticide-exposure-and-chronic-kidney-disease-new-findings-and-more-questions
#1
COMMENT
Geoffrey M Calvert
No abstract text is available yet for this article.
January 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/26162605/simultaneous-exposure-to-multiple-heavy-metals-and-glyphosate-may-contribute-to-sri-lankan-agricultural-nephropathy
#2
Channa Jayasumana, Sarath Gunatilake, Sisira Siribaddana
BACKGROUND: Sri Lankan Agricultural Nephropathy (SAN), a new form of chronic kidney disease among paddy farmers was first reported in 1994. It has now become the most debilitating public health issue in the dry zone of Sri Lanka. Previous studies showed SAN is a tubulo-interstitial type nephropathy and exposure to arsenic and cadmium may play a role in pathogenesis of the disease. METHODS: Urine samples of patients with SAN (N = 10) from Padavi-Sripura, a disease endemic area, and from two sets of controls, one from healthy participants (N = 10) from the same endemic area and the other from a non-endemic area (N = 10; Colombo district) were analyzed for 19 heavy metals and for the presence of the pesticide- glyphosate...
2015: BMC Nephrology
https://www.readbyqxmd.com/read/26099916/role-of-biomarkers-of-nephrotoxic-acute-kidney-injury-in-deliberate-poisoning-and-envenomation-in-less-developed-countries
#3
REVIEW
Fahim Mohamed, Zoltan H Endre, Nicholas A Buckley
Acute kidney injury (AKI) has diverse causes and is associated with increased mortality and morbidity. In less developed countries (LDC), nephrotoxic AKI (ToxAKI) is common and mainly due to deliberate ingestion of nephrotoxic pesticides, toxic plants or to snake envenomation. ToxAKI shares some pathophysiological pathways with the much more intensively studied ischaemic AKI, but in contrast to ischaemic AKI, most victims are young, previously healthy adults. Diagnosis of AKI is currently based on a rise in serum creatinine...
July 2015: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/25972749/effect-of-grapeseed-oil-on-diazinon-induced-physiological-and-histopathological-alterations-in-rats
#4
Atef Mohammed Al-Attar
The pollution of environment by toxic chemicals is a global and chronic problem. Human health risk due to exposure to chemical pollutants is constantly increasing. Pesticides form major toxic chemicals in environment. Scientifically, there is an obviously correlation between the exposure to pesticides and appearance of many diseases. Currently, the significance of natural products for health and medicine has been formidable. The present study investigated the effect of grapeseed oil in male rats exposed to diazinon...
May 2015: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/25763302/phosphate-fertilizer-is-a-main-source-of-arsenic-in-areas-affected-with-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#5
Channa Jayasumana, Saranga Fonseka, Ashvin Fernando, Kumudika Jayalath, Mala Amarasinghe, Sisira Siribaddana, Sarath Gunatilake, Priyani Paranagama
Chronic Kidney Disease of unknown etiology (CKDu) has escalated into an epidemic in North Central Province (NCP) and adjacent farming areas in the dry zone of Sri Lanka. Studies have shown that this special type of CKD is a toxic nephropathy and arsenic may play a causative role along with a number of other heavy metals. We investigated the hypothesis that chemical fertilizers and pesticide could be a source of arsenic. 226 samples of Fertilizers and 273 samples of pesticides were collected and analyzed using atomic absorption spectrometry and inductively coupled plasma mass spectrometry for arsenic and other heavy metals in two university laboratories...
2015: SpringerPlus
https://www.readbyqxmd.com/read/25596925/drinking-well-water-and-occupational-exposure-to-herbicides-is-associated-with-chronic-kidney-disease-in-padavi-sripura-sri-lanka
#6
Channa Jayasumana, Priyani Paranagama, Suneth Agampodi, Chinthaka Wijewardane, Sarath Gunatilake, Sisira Siribaddana
BACKGROUND: The chronic kidney disease of unknown etiology (CKDu) among paddy farmers in was first reported in 1994 and has now become most important public health issue in dry zone of Sri Lanka. The objective was to identify risk factors associated with the epidemic in an area with high prevalence. METHODS: A case control study was carried out in Padavi-Sripura hospital in Trincomalee district. CKDu patients were defined using health ministry criteria. All confirmed cases (N = 125) fulfilling the entry criteria were recruited to the study...
2015: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/25374332/the-environmental-cost-of-protein-food-choices
#7
Kitti Sranacharoenpong, Samuel Soret, Helen Harwatt, Michelle Wien, Joan Sabaté
OBJECTIVE: To investigate the resource efficiency and environmental impacts of producing one kilogram of edible protein from two plant- and three animal-protein sources. DESIGN: Primary source data were collected and applied to commodity production statistics to calculate the indices required to compare the environmental impact of producing 1 kg of edible protein from kidney beans, almonds, eggs, chicken and beef. Inputs included land and water for raising animals and growing animal feed, total fuel, and total fertilizer and pesticide for growing the plant commodities and animal feed...
August 2015: Public Health Nutrition
https://www.readbyqxmd.com/read/25069452/importance-of-arsenic-and-pesticides-in-epidemic-chronic-kidney-disease-in-sri-lanka
#8
LETTER
Channa Jayasumana, Ranil Gajanayake, Sisira Siribaddana
In a recent study published by the National Project team on chronic kidney diseases of unknown origin in Sri Lanka, we believe there to be flaws in the design, analysis, and conclusions, which should be discussed further. The authors wanted to emphasis Cadmium as the major risk factor for chronic kidney disease of unknown etiology in Sri Lanka while undermining the importance of Arsenic and nephrotoxic pesticides. To arrive at predetermined conclusions the authors appear have changed and misinterpreted their own results...
2014: BMC Nephrology
https://www.readbyqxmd.com/read/24348778/changes-in-monoclonal-hla-dr-antigen-expression-in-acute-organophosphorus-pesticide-poisoned-patients
#9
Chenyun Xia, Mi Wang, Qi Liang, Ling'an Yun, Housheng Kang, Lei Fan, Dongsheng Wang, Guoyuan Zhang
The aim of this study was to investigate changes in human leukocyte antigen (HLA)-DR expression of peripheral blood mononuclear cells (MNCs) in patients with acute organophosphorus pesticide poisoning (AOPP). HLA-DR antigen expression of peripheral blood MNCs was examined in 75 patients with AOPP, including 36 patients without multiple organ dysfunction syndrome (non-MODS) and 39 patients with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy individuals using flow cytometry assay. The associations between HLA-DR antigen expression and certain parameters were analyzed, including acute physiology and chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney function...
January 2014: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24216264/increased-level-of-organochlorine-pesticides-in-chronic-kidney-disease-patients-of-unknown-etiology-role-of-gstm1-gstt1-polymorphism
#10
Manushi Siddarth, Sudip K Datta, Md Mustafa, Rafat S Ahmed, Basu D Banerjee, Om P Kalra, Ashok K Tripathi
Chronic kidney disease (CKD) of unknown etiology represents about 16% of CKD patients in Indian subcontinents and 10% worldwide. The aetiology of CKD of unknown etiology remains unclear though epidemiological studies indicate the involvement of the environmental toxins. Organochlorine pesticides (OCPs) have been detected in general population in India. It is possible that polymorphism of xenobiotic metabolizing enzymes (XMEs) may play an important role in this process. In this we intend to find out blood levels of OCPs in CKD patients of unknown etiology and to evaluate the consequence of glutathione S-transferase (GST) gene polymorphism on the same...
February 2014: Chemosphere
https://www.readbyqxmd.com/read/24140367/resolving-the-enigma-of-the-mesoamerican-nephropathy-a-research-workshop-summary
#11
REVIEW
Catharina Wesseling, Jennifer Crowe, Christer Hogstedt, Kristina Jakobsson, Rebekah Lucas, David H Wegman
The First International Research Workshop on Mesoamerican Nephropathy (MeN) met in Costa Rica in November 2012 to discuss how to establish the extent and degree of MeN, examine relevant causal hypotheses, and focus efforts to control or eliminate the disease burden. MeN describes a devastating epidemic of chronic kidney disease of unknown origin predominantly observed among young male sugarcane cutters. The cause of MeN remains uncertain; however, the strongest hypothesis pursued to date is repeated episodes of occupational heat stress and water and solute loss, probably in combination with other potential risk factor(s), such as nonsteroidal anti-inflammatory drug and other nephrotoxic medication use, inorganic arsenic, leptospirosis, or pesticides...
March 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/22645066/study-on-organochlorine-pesticide-levels-in-chronic-kidney-disease-patients-association-with-estimated-glomerular-filtration-rate-and-oxidative-stress
#12
Manushi Siddharth, Sudip K Datta, Savita Bansal, Mohammad Mustafa, Basu D Banerjee, Om P Kalra, Ashok K Tripathi
Nephrotoxicity of organochlorine pesticides (OCPs) has been established in experimental animal models. This study was designed to evaluate the relationship of the blood OCPs level with the estimated glomerular filtration rate (eGFR) and oxidative stress (OS) in chronic kidney disease (CKD) patients. Patients in different stages of CKD (n = 150) and age, sex matched healthy controls (n = 96) were recruited. The blood OCPs level were analyzed by gas chromatography, and plasma levels of several OS parameters such as malondialdehyde (MDA), protein carbonyl, advanced oxidation protein products (AOPP), and total thiols were quantified by standard spectrophotometric methods...
June 2012: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/22315932/effect-of-chronic-pesticide-exposure-in-farm-workers-of-a-mexico-community
#13
Rolando Payán-Rentería, Guadalupe Garibay-Chávez, Raul Rangel-Ascencio, Veronica Preciado-Martínez, Laura Muñoz-Islas, Claudia Beltrán-Miranda, Salvador Mena-Munguía, Luis Jave-Suárez, Alfredo Feria-Velasco, Ruth De Celis
Pesticides are frequently used substances worldwide, even when the use of some of them is forbidden due to the recognized adverse effect they have on the health of not only the people who apply the pesticides, but also of those that consume the contaminated products. The objectives of this study were to know the health issues of farm workers chronically exposed to pesticides, to evaluate possible damage at genetic level, as well as to explore some hepatic, renal, and hematological alterations. A transversal comparative study was performed between 2 groups, one composed of 25 farm workers engaged in pesticide spraying, and a control group of 21 workers not exposed to pesticides; both groups belonged to the Nextipac community in Jalisco, Mexico...
2012: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/18409765/-occupational-exposure-and-chronic-heart-failure-severity
#14
D Beltrame, N Lo Cascio, D Miotto, C E Mapp, E De Rosa, P Boschetto
Chronic heart failure (CHF) is characterized by the inability of the heart to supply the body with sufficient amount of blood for metabolic and circulatory needs. The main risk factors for CHF development are: hypertension, type 2 diabetes, obesity, smoking, chronic kidney diseases. Many occupational exposures, such as extremes of heat or cold temperatures, prolonged exposure to noise, vibrations, pesticides, can contribute to etiology of this disease. The aim of our study was to evaluate if work can affect CHF severity...
July 2007: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/17643458/chronic-renal-failure-in-north-central-province-of-sri-lanka-an-environmentally-induced-disease
#15
Kamani P Wanigasuriya, Roshini J Peiris-John, Rajitha Wickremasinghe, Ariyasena Hittarage
This study was conducted to determine the aetiology of chronic renal failure (CRF) in the North Central Province of Sri Lanka. Patients (n=183) with CRF of unknown aetiology were compared with controls (n=200) who had no evidence of chronic renal dysfunction. Exposure to possible risk factors were determined by an interviewer-administered questionnaire. Being a farmer (P<0.001), using pesticides (P<0.001), drinking well water (P<0.001), a family history of renal dysfunction (P=0.001), use of ayurvedic treatment (P<0...
October 2007: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/16778371/a-series-of-patients-in-the-emergency-department-diagnosed-with-copper-poisoning-recognition-equals-treatment
#16
Nurullah Gunay, Cuma Yildirim, Ozgur Karcioglu, Nahide Ekici Gunay, Mehmet Yilmaz, Celalettin Usalan, Ataman Kose, Ismail Togun
Only scarce data are available on chronic copper poisoning in general toxicology literature. This paper reports four patients with chronic copper poisoning and one patient with acute poisoning. The cases with chronic poisoning in our study consisted of four members of a farmer family presenting to the emergency department (ED) with malaise, weakness, abdominal pain, headache, dizziness, tightness in the chest, leg and back pain, accompanied by significant anemia (hemoglobin [Hb]: 8.7 - 9.5 g/dl). They were hospitalized and investigated thoroughly, although there were no other findings or clues enlightening the etiology of anemia...
July 2006: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/16010641/kidney-injury-from-alternative-medicines
#17
REVIEW
Conny R D Colson, Marc E De Broe
In the developing world, up to 80% of the population uses traditional medicine for primary health care. In industrialized countries, adaptations of traditional medicine, termed "complementary" or "alternative" medicine (CAM), are used by a growing number of patients for preventive or palliative care. However, alternative medicine (AM) may be an important risk for the development of acute and chronic kidney injury because of several factors: nonconventional preparations rarely meet the required essential standards of consistency in composition and biological activity; many of these products contain undisclosed over-the-counter or prescription drugs or can be adulterated with hormones and glandular extracts; herbal preparations can be contaminated by pesticides and heavy metals; and because of errors in plant identification and confusing terminology, opportunities for mistakes and deliberate substitution can occur...
July 2005: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/15789534/-proteinuria-and-chronic-renal-failure-in-the-coast-of-el-salvador-detection-with-low-cost-methods-and-associated-factors
#18
R Gracia-Trabanino, J Domínguez, J M Jansà, A Oliver
OBJECTIVES: El Salvador has high mortality rates from chronic kidney disease (CKD). The actual prevalence and causes remain unknown and local resources are scarce. Previous studies have suggested very high prevalence in specific populations: adult male farmers living in the coastlands, with high frequency of pesticides exposure and alcohol consumption. This population has low incomes and poor healthcare accessibility. Our aim was to detect CKD cases in this population using proteinuria as an inexpensive initial screening, investigating associations with those characteristics and comparing them with another population from the midlands...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/15743722/acceleration-of-autoimmunity-by-organochlorine-pesticides-in-nzb-x-nzw-f1-mice
#19
Eric S Sobel, John Gianini, Edward J Butfiloski, Byron P Croker, Joel Schiffenbauer, Stephen M Roberts
Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men. In the (NZB times NZW)F1 mouse, a murine SLE model, the presence or absence of estrogen markedly influences the rate of progression of disease. Three organochlorine pesticides with estrogenic effects were administered chronically to ovariectomized female (NZB times NZW)F1 mice, and we measured the time to development of renal disease, the principal clinical manifestation of lupus in this model. Treatment with chlordecone, methoxychlor, or o,p -dichlorodiphenyltrichloroethane (o,p -DDT) significantly decreased the time to onset of renal impairment, as did treatment with 17ss-estradiol used as a positive control...
March 2005: Environmental Health Perspectives
https://www.readbyqxmd.com/read/14129593/chronic-toxicity-studies-on-diphenylamine
#20
F DEEDS
No abstract text is available yet for this article.
December 1963: Food and Cosmetics Toxicology
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