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https://www.readbyqxmd.com/read/29333806/asq-3-validation-of-the-ages-and-stages-questionnaire-for-the-detection-of-neurodevelopmental-disorders-in-argentine-children
#1
Ana M Romero Otalvaro, Nora Grañana, Nadia Gaeto, María de Los Á Torres, María N Zamblera, María A Vasconez, Claudia Misenta, María E Rouvier, Jane Squires
INTRODUCTION: The systematic assessment of child development in the first years of life is an essential component of pediatric health checkups. The Ages and Stages Questionnaire, third edition (ASQ-3) is the most validated scale, and has been recommended by the UNICEF to verify if children have a normal neurological development. It is a monitoring instrument to assess the main developmental areas, including communication, gross motor, fine motor, personal-social, and problem solving skills, and to compare the local population to the international development standards...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29328784/dna-encoded-chemical-libraries-a-selection-system-based-on-endowing-organic-compounds-with-amplifiable-information
#2
Dario Neri, Richard A Lerner
The discovery of organic ligands that bind specifically to proteins is a central problem in chemistry, biology, and the biomedical sciences. The encoding of individual organic molecules with distinctive DNA tags, serving as amplifiable identification bar codes, allows the construction and screening of combinatorial libraries of unprecedented size, thus facilitating the discovery of ligands to many different protein targets. Fundamentally, one links powers of genetics and chemical synthesis. After the initial description of DNA-encoded chemical libraries in 1992, several experimental embodiments of the technology have been reduced to practice...
January 12, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29328173/random-fiber-laser-based-on-artificially-controlled-backscattering-fibers
#3
Xiaoliang Wang, Daru Chen, Haitao Li, Lijuan She, Qiong Wu
The random fiber laser (RFL), which is a milestone in laser physics and nonlinear optics, has attracted considerable attention recently. Most previously reported RFLs are based on distributed feedback of Rayleigh scattering amplified through the stimulated Raman-Brillouin scattering effect in single-mode fibers, which require long-distance (tens of kilometers) single-mode fibers and high threshold, up to watt level, due to the extremely small Rayleigh scattering coefficient of the fiber. We proposed and demonstrated a half-open-cavity RFL based on a segment of an artificially controlled backscattering single-mode fiber with a length of 210 m, 310 m, or 390 m...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29327921/the-nature-and-reactivity-of-ferryl-heme-in-compounds-i-and-ii
#4
Peter C E Moody, Emma L Raven
Aerobic organisms have evolved to activate oxygen from the atmosphere, which allows them to catalyze the oxidation of different kinds of substrates. This activation of oxygen is achieved by a metal center (usually iron or copper) buried within a metalloprotein. In the case of iron-containing heme enzymes, the activation of oxygen is achieved by formation of transient iron-oxo (ferryl) intermediates; these intermediates are called Compound I and Compound II. The Compound I and II intermediates were first discovered in the 1930s in horseradish peroxidase, and it is now known that these same species are used across the family of heme enzymes, which include all of the peroxidases, the heme catalases, the P450s, cytochrome c oxidase, and NO synthase...
January 12, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29327140/children-s-experiences-of-congenital-heart-disease-a-systematic-review-of-qualitative-studies
#5
REVIEW
Lauren S H Chong, Dominic A Fitzgerald, Jonathan C Craig, Karine E Manera, Camilla S Hanson, David Celermajer, Julian Ayer, Nadine A Kasparian, Allison Tong
We aimed to describe the experiences of children and adolescents with congenital heart disease (CHD). Electronic databases were searched until August 2016. Qualitative studies of children's perspectives on CHD were included. Data was extracted using thematic synthesis. From 44 studies from 12 countries involving 995 children, we identified 6 themes: disrupting normality (denying the diagnosis, oscillating between sickness and health, destabilizing the family dynamic), powerlessness in deteriorating health (preoccupation with impending mortality, vulnerability to catastrophic complications, exhaustion from medical testing), enduring medical ordeals (traumatized by invasive procedures, disappointed by treatment failure, displaced by transition, valuing empathy and continuity in care, overcoming uncertainty with information), warring with the body (losing stamina, distressing inability to participate in sport, distorted body image, testing the limits), hampering potential and goals (feeling disabled, unfair judgment and exclusion, difficulties with academic achievement, limiting attainment and maintenance of life milestones), and establishing one's own pace (demarcating disease from life, determination to survive, taking limitations in their stride, embracing the positives, finding personal enrichment, relying on social or spiritual support)...
January 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29326522/fragile-x-syndrome-a-rare-case-report-with-unusual-oral-features
#6
Prayas Ray, Arpanna Singh, Jayanta Kumar Dash, Prasanna Kumar Sahoo, Jitendra Kumar Dash
Fragile X syndrome (FXS) is a rare variant of special health-care need demonstrating delayed developmental milestones and associated with intellectual and emotional disabilities ranging from learning problem to mental retardation. The syndrome is usually not diagnosed until 8-9 years of age since the clinical manifestations of the syndrome are greatly attenuated in childhood. The physical characteristics such as facial features, hyperactivity, attention deficit, autistic behavior, and macroorchidism are quite evident in younger age group...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326244/gene-therapy-comes-of-age
#7
REVIEW
Cynthia E Dunbar, Katherine A High, J Keith Joung, Donald B Kohn, Keiya Ozawa, Michel Sadelain
After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic armamentarium for a variety of inherited and acquired human diseases. Gene therapies for inherited immune disorders, hemophilia, eye and neurodegenerative disorders, and lymphoid cancers recently progressed to approved drug status in the United States and Europe, or are anticipated to receive approval in the near future. In this Review, we discuss milestones in the development of gene therapies, focusing on direct in vivo administration of viral vectors and adoptive transfer of genetically engineered T cells or hematopoietic stem cells...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29325349/-introduction-and-interpretation-of-guidelines-on-thromboprophylaxis-in-the-perioperative-period-of-urological-surgery
#8
X Wang, Z Y Liu
Venous thromboembolism had drawn great attention of global experts, as it is the third leading cause of cardiovascular-associated death, ranking after coronary heart disease and stroke. Numerous health care organizations had introduced guidelines for thromboprophylaxis during the perioperative period in their own fields. The paper reviewed the available guidelines pertaining to urological surgery from America Urological Association, American College of Chest Physicians and European Association of Urology. Compared with the first two guidelines, the European Association of Urology guideline is a milestone which recommended the most detailed prophylactic measures for the procedure-specific and patient-specific according to the evidence-based medicine...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29324685/novel-spectroscopic-and-electrochemical-sensors-and-nanoprobes-for-the-characterization-of-food-and-biological-antioxidants
#9
REVIEW
Reşat Apak, Sema Demirci Çekiç, Ayşem Üzer, Saliha Esin Çelik, Mustafa Bener, Burcu Bekdeşer, Ziya Can, Şener Sağlam, Ayşe Nur Önem, Erol Erçağ
Since an unbalanced excess of reactive oxygen/nitrogen species (ROS/RNS) causes various diseases, determination of antioxidants that can counter oxidative stress is important in food and biological analyses. Optical/electrochemical nanosensors have attracted attention in antioxidant activity (AOA) assessment because of their increased sensitivity and selectivity. Optical sensors offer advantages such as low cost, flexibility, remote control, speed, miniaturization and on-site/in situ analysis. Electrochemical sensors using noble metal nanoparticles on modified electrodes better catalyze bioelectrochemical reactions...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29322964/natural-history-of-a-cohort-of-duchenne-muscular-dystrophy-children-seen-between-1998-and-2014-an-observational-study-from-south-india
#10
Ravinder-Jeet Singh, Mahadevappa Manjunath, Veeramani Preethish-Kumar, Kiran Polavarapu, Seena Vengalil, Priya T Thomas, Kandavel Thennarasu, Narayanappa Gayathri, Deepha Sekar, Saraswati Nashi, Atchayaram Nalini
BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. There are no large studies describing its natural course from India. MATERIALS AND METHODS: Immunohistochemically/genetically confirmed DMD patients diagnosed between 1998 and 2014 were ambispectively included. The main aim was to study the natural course of motor milestones, i.e., age at onset of wheelchair status, bedbound state, and age at death, which were considered as primary outcome measures...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322302/the-superiority-of-sucrose-cushion-centrifugation-to-ultrafiltration-and-pegylation-in-generating-high-titer-lentivirus-particles-and-transducing-stem-cells-with-enhanced-efficiency
#11
Mahdi Eskandarian Boroujeni, Mossa Gardaneh
Viral gene delivery is hailed as a great milestone in gene-based therapeutic approaches. The human immunodeficiency virus-derived lentiviral vectors (LVs) are advantageous in infecting both dividing and non-dividing cells leading to continuous expression of transgenes. A variety of protocols are available for concentration of LVs. We primarily generated our internal ribosome entry site (IRES)-based LVs. Virus titration and transduction efficiency were compared between various strategies that included sucrose cushion centrifugation (SCC), protein column ultrafiltration and polyethylene glycol precipitation...
January 10, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29321904/offspring-of-older-parents-are-smaller-but-no-less-bilaterally-symmetrical-than-offspring-of-younger-parents-in-the-aquatic-plant-lemna-turionifera
#12
Eric J Ankutowicz, Robert A Laird
Offspring quality decreases with parental age in many taxa, with offspring of older parents exhibiting reduced life span, reproductive capacity, and fitness, compared to offspring of younger parents. These "parental age effects," whose consequences arise in the next generation, can be considered as manifestations of parental senescence, in addition to the more familiar age-related declines in parent-generation survival and reproduction. Parental age effects are important because they may have feedback effects on the evolution of demographic trajectories and longevity...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321713/two-branches-of-the-same-tree-a-brief-history-of-turkish-neuropsychiatric-society-1914-2016
#13
Fatih Artvinli, Şahap Erkoç, Fulya Kardeş
Introduction: The aim of this article is to provide a brief history of Turkish Neuropsychiatric Society by examining its institutional background, the milestones within its history, and the major activities undertaken by the organization during the years. Methods: Firstly, the books, journals, and articles that are related to the history of psychiatry and neurology in Turkey have been reviewed and the information that can explain the history of the society has been brought together...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29320294/arresting-leprosy-therapeutic-outcomes-besides-cure
#14
Raúl Necochea López
This essay focuses on the use of the concept of "arrest" in Hansen's disease (leprosy) in the United States in the early to middle part of the 20th century, as well as the transformations the concept underwent with the arrival of sulfone drugs and the implications of these changes for patients and public health officers. An "arrest" was a therapeutic outcome characterized by a long course of treatment, noncontagiousness, a very small chance of reactivation, and a need for postdischarge maintenance that depended on sociomedical infrastructures beyond the clinic as well as self-imposed lifestyle limitations...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29319278/the-use-of-minoxidil-in-the-treatment-of-male-and-female-androgenetic-alopecia-a-story-of-more-than-30-years
#15
Mauro Barbareschi
Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. A large part of hair treatment scientific literature confirms the efficacy of topically applied minoxidil in humans. In particular, patients treated with minoxidil showed a significant increase in "non vellus" hair count starting from baseline...
February 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29318324/strategies-for-a%C3%A2-regenerative-therapy-of-hearing-loss
#16
REVIEW
M Diensthuber, T Stöver
Despite impressive technical progress in the field of conventional hearing aids and implantable hearing systems, the hopes for the treatment of inner ear diseases such as hearing loss and tinnitus have become increasingly directed toward regenerative therapeutic approaches. This review discusses the currently most promising strategies for hair cell regeneration in the inner ear to treat hearing loss, including stem cell-based, gene transfer-based, and pharmacological interventions. Furthermore, previous milestones and ground-breaking work in this scientific field are identified...
January 9, 2018: HNO
https://www.readbyqxmd.com/read/29317466/the-relationship-between-form-and-function-throughout-the-history-of-excitation-contraction-coupling
#17
REVIEW
Clara Franzini-Armstrong
The concept of excitation-contraction coupling is almost as old as Journal of General Physiology It was understood as early as the 1940s that a series of stereotyped events is responsible for the rapid contraction response of muscle fibers to an initial electrical event at the surface. These early developments, now lost in what seems to be the far past for most young investigators, have provided an endless source of experimental approaches. In this Milestone in Physiology, I describe in detail the experiments and concepts that introduced and established the field of excitation-contraction coupling in skeletal muscle...
January 9, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29316247/hydrogen-storage-in-porous-materials-status-milestones-and-challenges
#18
REVIEW
Ángel Berenguer-Murcia, Juan Pablo Marco-Lozar, Diego Cazorla-Amorós
In this account the most relevant advancements in hydrogen storage in porous materials are presented. These include the current state-of-the-art, the challenges which have been overcome, and the hurdles which still remain. The most important milestones which will be discussed in this work will be the development of new apparatuses capable of delivering reliable results under a broad range of operational conditions, in which analysis temperature and pressure are critical parameters. Other aspects such as the materials storage capacity in gravimetric and volumetric terms will be critically discussed to identify the conditions required from an ideal material...
January 9, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29310619/valuing-breastfeeding-a-qualitative-study-of-women-s-experiences-of-a-financial-incentive-scheme-for-breastfeeding
#19
Maxine Johnson, Barbara Whelan, Clare Relton, Kate Thomas, Mark Strong, Elaine Scott, Mary J Renfrew
BACKGROUND: A cluster randomised controlled trial of a financial incentive for breastfeeding conducted in areas with low breastfeeding rates in the UK reported a statistically significant increase in breastfeeding at 6-8 weeks. In this paper we report an analysis of interviews with women eligible for the scheme, exploring their experiences and perceptions of the scheme and its impact on breastfeeding to support the interpretation of the results of the trial. METHODS: Semi-structured interviews were carried out with 35 women eligible for the scheme during the feasibility and trial stages...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29309940/interim-analysis-of-a-prospective-multi-institutional-study-of-surgery-resident-experience-with-flexibility-in-surgical-training
#20
Darren R Cullinan, Paul E Wise, Keith A Delman, John R Potts, Michael M Awad, Timothy J Eberlein, Mary E Klingensmith
BACKGROUND: The Flexibility in Surgical Training (FIST) consortium project was designed to evaluate the feasibility and resident outcomes of optional subspecialty-focused training within general surgery residency training. STUDY DESIGN: Following approval by the American Board of Surgery, R4 and R5 residents were permitted to customize up to 12 of the final 24 months of residency for early tracking into one of nine subspecialty tracks. A prospective IRB-approved study was designed across seven institutions to evaluate the impact of this option on operative experience, in-service exam (ABSITE) and ACGME milestone performance, and resident and program director (PD) perceptions...
January 5, 2018: Journal of the American College of Surgeons
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