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https://www.readbyqxmd.com/read/28812804/barriers-to-the-implementation-of-the-health-and-rehabilitation-articles-of-the-united-nations-convention-on-the-rights-of-persons-with-disabilities-in-south-africa
#1
Meghan Hussey, Malcolm MacLachlan, Gubela Mji
BACKGROUND: The United Nations (UN) Convention on the Rights of Persons with Disabilities (CRPD) is a milestone in the recognition of the human rights of persons with disabilities, including the right to health and rehabilitation. South Africa has signed and ratified the CRPD but still has a long way to go in reforming policies and systems in order to be in compliance with the convention. This paper seeks to fill a gap in the literature by exploring what the barriers to the implementation of the health and rehabilitation articles of the CRPD are, as identified by representatives of the disability community...
August 28, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28809760/the-milestone-of-non-invasive-prenatal-identification-of-chromosomal-abnormalities-in-fetal-trophoblasts-recovered-from-maternal-blood
#2
Jaime Garcia-Heras
Two recent studies demonstrated that array CGH and NGS allow identification of chromosomal abnormalities in fetal trophoblasts circulating in maternal blood. This remarkable breakthrough paves the way for an improved assay that supersedes the performance of non-invasive prenatal testing (NIPT) in cell-free fetal DNA. Furthermore, it is foreseeable to expand the use of this new genomic analysis in trophoblasts to uncover single gene mutations of clinical significance prenatally.
2017: Journal of the Association of Genetic Technologists
https://www.readbyqxmd.com/read/28807476/a-model-for-a-career-in-a-specialty-of-general-surgery-one-surgeon-s-opinion
#3
Bona Ko, Christopher R McHenry
BACKGROUND: The integration of general and endocrine surgery was studied as a potential career model for fellowship trained general surgeons. METHODS: Case logs collected from 1991-2016 and academic milestones were examined for a single general surgeon with a focused interest in endocrine surgery. Operations were categorized using CPT codes and the 2017 ACGME "Major Case Categories" and there frequencies were determined. RESULTS: 10,324 operations were performed on 8209 patients...
August 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28804634/muscle-mri-findings-in-a-one-year-old-girl-with-merosin-deficient-congenital-muscular-dystrophy-type-1a-due-to-lama2-mutation-a-case-report
#4
Yingyin Liang, Guidian Li, Songlin Chen, Rongxing He, Xiangxue Zhou, Yingming Chen, Xue Xu, Ronglan Zhu, Cheng Zhang
The objective of the present study was to characterize the muscle magnetic resonance imaging (MRI) features of a 1-year-old girl with merosin-deficient congenital muscular dystrophy type 1A (MDC1A). Beginning as an infant, this patient exhibited severe hypotonia and proximal weakness, as well as delays in developmental milestones. Her serum creatine kinase levels at 3 months, 8 months and 1 year were 2,959, 1,621 and 1,659 U/l, respectively. Brain MRI indicated symmetric, mild T1WI low, mild T2WI and FLAIR high radial patterns in the white matter of the Cornu posterius of the ventricular lateral...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28803588/the-history-of-paediatric-cardiology-on-stamps
#5
Hazım A Gursu, Ibrahim I Cetin
Paediatric cardiology is arguably the sub-specialty in which the greatest advances have been made in both disease diagnosis and treatment over the past half a century. Paediatric cardiology emerged as a discipline in the 1930s. Since then, advances in imaging techniques such as echocardiography, angiography, CT, or magnetic resonance and extracorporeal circulation have provided excellent diagnosis and treatment of CHD. The pioneers of paediatric cardiology are more than eponyms, for each used in new and original ways the tools and concepts available in his or her era...
August 14, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28802926/nonmotor-symptoms-and-natural-history-of-parkinson-s-disease-evidence-from-cognitive-dysfunction-and-role-of-noninvasive-interventions
#6
Roberta Biundo, Eleonora Fiorenzato, Angelo Antonini
Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by motor and nonmotor symptoms (NMS). Several subsequent studies substantiate the great functional burden related to NMS, their progression, and negative effect on quality of life in PD. Additional evidence indicates interesting relationships between striatal dopaminergic function and NMS. The basal ganglia are implicated in the modulation and integration of sensory information and pain, bladder function is under control of both inhibitory (D1) and facilitatory (D2) dopaminergic inputs, finally reduced dopaminergic activity in the mesocortical and mesolimbic pathways is involved in the development of several NMS including mood, motivational, and cognitive alterations...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28800997/palliative-care-and-human-rights-a-decade-of-evolution-in-standards
#7
Tamar Ezer, Diederik Lohman, Gabriela B de Luca
CONTEXT: Human rights standards to address palliative care have developed over the last decade. OBJECTIVES: This paper aims to examine key milestones in the evolution of human rights standards to address palliative care, relevant advocacy efforts, and areas for further growth. METHODS: The paper provides an analysis of human rights standards in the context of palliative care through the lens of the right to health, freedom from torture and ill treatment, and the rights of older persons and children...
August 8, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28800551/using-transgenic-plants-and-modified-plant-viruses-for-the-development-of-treatments-for-human-diseases
#8
REVIEW
Hwei-San Loh, Brian J Green, Vidadi Yusibov
Production of proteins in plants for human health applications has become an attractive strategy attributed by their potentials for low-cost production, increased safety due to the lack of human or animal pathogens, scalability and ability to produce complex proteins. A major milestone for plant-based protein production for use in human health was achieved when Protalix BioTherapeutics produced taliglucerase alfa (Elelyso(®)) in suspension cultures of a transgenic carrot cell line for the treatment of patients with Gaucher's disease, was approved by the USA Food and Drug Administration in 2012...
August 8, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28800502/spotlight-on-equality-of-employment-opportunities-a-qualitative-study-of-job-seeking-experiences-of-graduating-nurses-and-physiotherapists-from-black-and-minority-ethnic-backgrounds
#9
John Hammond, Sylvie Marshall-Lucette, Nigel Davies, Fiona Ross, Ruth Harris
BACKGROUND: There is growing attention in the UK and internationally to the representation of black and minority ethnic groups in healthcare education and the workplace. Although the NHS workforce is very diverse, ethnic minorities are unevenly spread across occupations, and considerably underrepresented in senior positions. Previous research has highlighted that this inequality also exists at junior levels with newly qualified nurses from non-White/British ethnic groups being less likely to get a job at graduation than their White/British colleagues...
August 1, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28799581/notable-deals-in-the-pharmaceutical-industry-in-the-first-quarter-of-2017
#10
E Cruces
During the first quarter of 2017, Cortellis Competitive Intelligence had 1,073 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This meant a slight increase on the last quarter (1,022) and a similar volume on the same quarter for the previous 1 year (1,141). However, this quarter showed a significant augment in deals worth more than USD 0.5 billion on the last quarter (17 vs. 12). This article will focus on highlighting a number of the most valuable and notable deals forged during the quarter, as well as a selection of deals from some of the most prolific deal makers...
June 2017: Drugs of Today
https://www.readbyqxmd.com/read/28799378/heterogeneous-nucleation-from-a-supercooled-ionic-liquid-on-a-carbon-surface
#11
Xiaoxia He, Yan Shen, Francisco R Hung, Erik E Santiso
Classical molecular dynamics simulations were used to study the nucleation of the crystal phase of the ionic liquid [dmim(+)][Cl(-)] from its supercooled liquid phase, both in the bulk and in contact with a graphitic surface of D = 3 nm. By combining the string method in collective variables [Maragliano et al., J. Chem. Phys. 125, 024106 (2006)], with Markovian milestoning with Voronoi tessellations [Maragliano et al., J. Chem. Theory Comput. 5, 2589-2594 (2009)] and order parameters for molecular crystals [Santiso and Trout, J...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28792773/easy-to-apply-polyoxazoline-based-coating-for-precise-and-long-term-control-of-neural-patterns
#12
Serge Weydert, Stefan Zürcher, Stefanie Tanner, Ning Zhang, Rebecca Ritter, Thomas Peter, Mathias J Aebersold, Greta Thompson-Steckel, Csaba Forró, Markus Rottmar, Flurin Stauffer, Irene A Valassina, Giulia Morgese, Edmondo M Benetti, Samuele Tosatti, János Vörös
Arranging cultured cells in patterns via surface modification is a tool used by biologists to answer questions in a specific and controlled manner. In the past decade, bottom-up neuroscience emerged as a new application, which aims to get a better understanding of the brain via reverse engineering and analyzing elementary circuitry in vitro. Building well-defined neural networks is the ultimate goal. Antifouling coatings are often used to control neurite outgrowth. Because erroneous connectivity alters the entire topology and functionality of minicircuits, the requirements are demanding...
August 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28792171/glycemic-pentad
#13
Glycemic Pentad Forum
BACKGROUND: Conventionally, diabetes management involved targeting the triad of FPG, PPG, and HbA1c. However, several studies have suggested the quintessential need for a paradigm shift to incorporate glycemic variability and quality of life in the holistic diabetes control regimen. AIM: To generate a consensus and ratify the position of Glycemic Variability (GV) and Quality of Life (QOL), along with the traditional triad, in diabetes management in India. To evaluate whether the triple fixed dose combination of metformin, glimepiride, and voglibose can accomplish the goals of glycemic pentad...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28791158/gamma-ray-bursts-and-their-use-as-cosmic-probes
#14
REVIEW
Patricia Schady
Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonova coincident with a short GRB, and the identification of samples of low-luminosity, ultra-long and highly dust-extinguished GRBs...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28789281/arrayed-waveguide-grating-spectrometers-for-astronomical-applications-new-results
#15
Pradip Gatkine, Sylvain Veilleux, Yiwen Hu, Joss Bland-Hawthorn, Mario Dagenais
One promising application of photonics to astronomical instrumentation is the miniaturization of near-infrared (NIR) spectrometers for large ground- and space-based astronomical telescopes. Here we present new results from our effort to fabricate arrayed waveguide grating (AWG) spectrometers for astronomical applications entirely in-house. Our latest devices have a peak overall of ∼23%, a spectral resolving power (λ/δλ) of ~1300, and cover the entire H band (1450-1650 nm) for Transverse Electric (TE) polarization...
July 24, 2017: Optics Express
https://www.readbyqxmd.com/read/28788892/iteratively-seeded-mode-locking
#16
Victor G Bucklew, William H Renninger, Perry S Edwards, Zhiwen Liu
Ultrashort pulsed mode-locked lasers enable research at new time-scales and revolutionary technologies from bioimaging to materials processing. In general, the performance of these lasers is determined by the degree to which the pulses of a particular resonator can be scaled in energy and pulse duration before destabilizing. To date, milestones have come from the application of more tolerant pulse solutions, drawing on nonlinear concepts like soliton formation and self-similarity. Despite these advances, lasers have not reached the predicted performance limits anticipated by these new solutions...
June 12, 2017: Optics Express
https://www.readbyqxmd.com/read/28786971/attainment-of-gross-motor-milestones-in-children-with-down-syndrome-in-kosovo-developmental-perspective
#17
Samire Beqaj, Njomza Jusaj, Vujica Živković
Aim To investigate the age (in months) at which motor skills are developed in children with Down syndrome (DS), and compare it to the age of the development of the same skills in both, children with typical development (TD), and children with DS reported by four other studies. Methods Sixteen children (7 girls and 9 boys) were monthly assessed for the development of nineteen motor skills between 2008 and 2011. The mean ages when the skills were accomplished were presented using descriptive statistics. Independent T-samples test (significance < 0...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28785084/a-pluripotent-stem-cell-based-model-for-post-implantation-human-amniotic-sac-development
#18
Yue Shao, Kenichiro Taniguchi, Ryan F Townshend, Toshio Miki, Deborah L Gumucio, Jianping Fu
Development of the asymmetric amniotic sac-with the embryonic disc and amniotic ectoderm occupying opposite poles-is a vital milestone during human embryo implantation. Although essential to embryogenesis and pregnancy, amniotic sac development in humans remains poorly understood. Here, we report a human pluripotent stem cell (hPSC)-based model, termed the post-implantation amniotic sac embryoid (PASE), that recapitulates multiple post-implantation embryogenic events centered around amniotic sac development...
August 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28785015/grating-based-phase-contrast-and-dark-field-computed-tomography-a-single-shot-method
#19
Maximilian von Teuffenbach, Thomas Koehler, Andreas Fehringer, Manuel Viermetz, Bernhard Brendel, Julia Herzen, Roland Proksa, Ernst J Rummeny, Franz Pfeiffer, Peter B Noël
Grating-based X-ray interferometry offers vast potential for imaging materials and tissues that are not easily visualised using conventional X-ray imaging. Tomographic reconstruction based on X-ray interferometric data provides not only access to the attenuation coefficient of an object, but also the refractive index and information about ultra-small-angle scattering. This improved functionality comes at the cost of longer measurement times because existing projection-based signal extraction algorithms require not only a single measurement per projection angle but several with precise grating movements in between...
August 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28784167/identification-of-a-novel-mutation-in-pex10-in-a-patient-with-attenuated-zellweger-spectrum-disorder-a-case-report
#20
Maria Blomqvist, Karin Ahlberg, Julia Lindgren, Sacha Ferdinandusse, Jorge Asin-Cayuela
BACKGROUND: The peroxisome biogenesis disorders, which are caused by mutations in any of 13 different PEX genes, include the Zellweger spectrum disorders. Severe defects in one of these PEX genes result in the absence of functional peroxisomes which is seen in classical Zellweger syndrome. These patients present with hypotonia and seizures shortly after birth. Other typical symptoms are dysmorphic features, liver disease, retinal degeneration, sensorineural deafness, polycystic kidneys, and the patient does not reach any developmental milestones...
August 8, 2017: Journal of Medical Case Reports
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