keyword
https://read.qxmd.com/read/38546956/dimdazenil-first-approval
#1
REVIEW
Yahiya Y Syed
Dimdazenil (Junoenil® ) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)A receptor that is being developed by Zhejiang Jingxin Pharmaceutical in collaboration with Evotec for the treatment of insomnia. Dimdazenil is designed to overcome issues associated with full GABAA receptor agonists, such as tolerance, withdrawal symptoms and associated adverse effects. On 29 November 2023, dimdazenil oral capsules received approval in China for the short-term treatment of insomnia...
March 28, 2024: Drugs
https://read.qxmd.com/read/38546568/being-out-in-high-school-positive-implications-for-well-being-in-three-u-s-cohorts-of-sexual-minority-adults
#2
JOURNAL ARTICLE
Armin A Dorri, Stephen T Russell
For lesbian, gay, bisexual, or queer (i.e., sexual minority [SM]) youth, coming out is an important developmental milestone and is typically associated with positive well-being. However, coming out in high school may entail a higher risk of school-based victimization. Due to the greater risk of homophobic bullying, the implications of being out in adolescence and well-being later in adulthood remain unclear. Using data from a national probability survey (Generations Study) of three distinct age cohorts of SM adults ( N = 1,474) in the United States, this study (a) examined how being out at school in adolescence affects general well-being in adulthood and (b) SM-specific well-being in adulthood, and (c) examined if these associations differ by cohort...
March 28, 2024: Developmental Psychology
https://read.qxmd.com/read/38545666/sex-specific-developmental-scales-for-surveillance
#3
JOURNAL ARTICLE
Tamar Sudry, Guy Amit, Deena R Zimmerman, Meytal Avgil Tsadok, Ravit Baruch, Hadar Yardeni, Pinchas Akiva, Dror Ben Moshe, Eitan Bachmat, Yair Sadaka
BACKGROUND: Developmental surveillance, conducted routinely worldwide, is fundamental for early detection of children at risk for developmental delay. We aimed to explore sex-related difference in attainment rates of developmental milestones and to evaluate the clinical need for separate sex-specific scales. METHODS: This is a cross-sectional, natiowide retrospective study, utilizing data from a national child surveillance program of ∼1000 maternal child health clinics...
March 28, 2024: Pediatrics
https://read.qxmd.com/read/38543740/evolution-of-virology-science-history-through-milestones-and-technological-advancements
#4
REVIEW
Kunlan Zuo, Wanying Gao, Zongzhen Wu, Lei Zhang, Jiafeng Wang, Xuefan Yuan, Chun Li, Qiangyu Xiang, Lu Lu, Huan Liu
The history of virology, which is marked by transformative breakthroughs, spans microbiology, biochemistry, genetics, and molecular biology. From the development of Jenner's smallpox vaccine in 1796 to 20th-century innovations such as ultrafiltration and electron microscopy, the field of virology has undergone significant development. In 1898, Beijerinck laid the conceptual foundation for virology, marking a pivotal moment in the evolution of the discipline. Advancements in influenza A virus research in 1933 by Richard Shope furthered our understanding of respiratory pathogens...
February 28, 2024: Viruses
https://read.qxmd.com/read/38540288/current-knowledge-on-the-use-of-neuromonitoring-in-thyroid-surgery
#5
REVIEW
Beata Wojtczak, Karolina Sutkowska-Stępień, Mateusz Głód, Krzysztof Kaliszewski, Krzysztof Sutkowski, Marcin Barczyński
Thyroid surgery rates have tripled over the past three decades, making it one of the most frequently performed procedures within general surgery. Thyroid surgery is associated with the possibility of serious postoperative complications which have a significant impact on the patient's quality of life. Recurrent laryngeal nerve (RLN) palsy and external branch of the superior laryngeal nerve (EBSLN) palsy are, next to hypoparathyroidism and postoperative bleeding, some of the most common complications. The introduction of neuromonitoring into thyroid surgery, which enabled both the confirmation of anatomical integrity and the assessment of laryngeal nerve function, was a milestone that began a new era in thyroid surgery...
March 18, 2024: Biomedicines
https://read.qxmd.com/read/38539569/regulation-of-pd-l1-expression-by-yy1-in-cancer-therapeutic-efficacy-of-targeting-yy1
#6
REVIEW
Ana Dillen, Indy Bui, Megan Jung, Stephanie Agioti, Apostolos Zaravinos, Benjamin Bonavida
During the last decade, we have witnessed several milestones in the treatment of various resistant cancers including immunotherapeutic strategies that have proven to be superior to conventional treatment options, such as chemotherapy and radiation. This approach utilizes the host's immune response, which is triggered by cancer cells expressing tumor-associated antigens or neoantigens. The responsive immune cytotoxic CD8+ T cells specifically target and kill tumor cells, leading to tumor regression and prolongation of survival in some cancers; however, some cancers may exhibit resistance due to the inactivation of anti-tumor CD8+ T cells...
March 21, 2024: Cancers
https://read.qxmd.com/read/38539548/mutations-in-the-serine-threonine-kinase-braf-oncogenic-drivers-in-solid-tumors
#7
REVIEW
Paola Roa, Nicole Virginia Bremer, Valentina Foglizzo, Emiliano Cocco
Since their discovery in 2002, BRAF mutations have been identified as clear drivers of oncogenesis in several cancer types. Currently, their incidence rate is nearly 7% of all solid tumors with BRAF V600E constituting approximately 90% of these diagnoses. In melanoma, thyroid cancer, and histiocytic neoplasms, BRAF hotspot mutations are found at a rate of about 50%, while in lung and colorectal cancers they range from 3% to 10% of reported cases. Though present in other malignancies such as breast and ovarian cancers, they constitute a small portion of diagnoses (<1%)...
March 20, 2024: Cancers
https://read.qxmd.com/read/38539456/her2-positive-early-breast-cancer-time-for-ultimate-de-escalation
#8
REVIEW
Nikolas Tauber, Christoph Cirkel, Anna Claussen, Franziska Fick, Emmanuel Kontomanolis, Natalia Krawczyk, Achim Rody, Maggie Banys-Paluchowski
De-escalation is currently taking place in both the surgical and systemic treatment of breast cancer. The introduction of trastuzumab, the first monoclonal antibody against the HER2 receptor, over 20 years ago was a milestone in the treatment of HER2-positive breast cancer and marked the beginning of a new era in targeted tumor therapy. In the sense of de-escalation, omitting non-targeted cytotoxic chemotherapy altogether is often hailed as the ultimate goal of oncological research. Especially in cases of small, node-negative, HER2-positive early breast cancer, it remains a challenge for clinicians to establish the safest and most efficient treatment plan while considering the significant potential for toxic side effects associated with chemotherapy and HER2-targeted therapy, and the generally excellent prognosis...
March 11, 2024: Cancers
https://read.qxmd.com/read/38537623/successful-postnatal-tracheobronchoplasty-for-unilateral-congenital-high-airway-obstruction-syndrome-chaos-due-to-mainstem-bronchial-atresia
#9
Timothy M Crombleholme, Jennifer D Smith, Reenu Eapen, Maythem Al-Kubaisi, Kevin Magee
INTRODUCTION: Unilateral congenital high airway obstruction syndrome (CHAOS) is caused by a complete obstruction of a mainstem bronchus with resulting hyperinflation and accelerated growth of one lung, severe mediastinal shift and hydrops. Spontaneous perforation of the atresia has been observed in CHAOS which allows hydrops to resolve but hyperinflation, mediastinal shift and a critical airway obstruction persists as the perforation is usually pinhole-sized. CASE PRESENTATION: We present a case of unilateral CHAOS presenting at 26 2/7 weeks' with observed-to-expected total lung volume (O/E TLV) of 203% with spontaneous perforation occurring at 28 weeks' with resolution of hydrops but persistence of hyperinflation and mediastinal shift with an O/E TLV of 60...
March 27, 2024: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/38537301/-sapphire-establishment-of-s-mall-a-nimal-p-roton-and-ph-oton-i-mage-guided-r-adiation-e-xperiments
#10
JOURNAL ARTICLE
Moritz Schneider, Joshua Dietrich Schilz, Michael Schürer, Sebastian Gantz, Anne Dreyer, Gert Rothe, Falk Tillner, Elisabeth Bodenstein, Felix Horst, Elke Beyreuther
The in vivo evolution of radiotherapy necessitates innovative platforms for preclinical investigation, bridging the gap between bench research and clinical applications. Understanding the nuances of radiation response, specifically tailored to proton and photon therapies, is critical for optimizing treatment outcomes. Within this context, preclinical in vivo experimental setups incorporating image guidance for both photon and proton therapies are pivotal, enabling the translation of findings from small animal models to clinical settings...
March 27, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38537179/dispersion-control-over-molecule-cohesion-exploiting-and-dissecting-the-tipping-power-of-aromatic-rings
#11
JOURNAL ARTICLE
Ricardo A Mata, Tlektes Zhanabekova, Daniel A Obenchain, Martin A Suhm
ConspectusWe have learned over the past years how London dispersion forces can be effectively used to influence or even qualitatively tip the structure of aggregates and the conformation of single molecules. This happens despite the fact that single dispersion contacts are much weaker than competing polar forces. It is a classical case of strength by numbers, with the importance of London dispersion forces scaling with the system size. Knowledge about the tipping points, however difficult to attain, is necessary for a rational design of intermolecular forces...
March 27, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38535583/viral-infections-are-they-a-trigger-and-risk-factor-of-alzheimer-s-disease
#12
REVIEW
Meagan D Rippee-Brooks, Wenzhe Wu, Jianli Dong, Miguel Pappolla, Xiang Fang, Xiaoyong Bao
Alzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to AD...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38533995/-eradication-of-poliomyelitis-in-spain-what-has-happened-in-the-last-decade
#13
JOURNAL ARTICLE
Pablo Estrella-Porter, Ana Fernández Dueñas, Carmen Olmedo Lucerón, Elena Cantero Gudino, Aurora Limia Sánchez
On the 60th anniversary of the initiation of the polio vaccination campaign in Spain, the significant milestone in achieving disease control is highlighted. There has been a shift from an incidence of over 2,000 yearly cases in the 1960s to a sustained absence of wild poliovirus (WPV) since 1988. Despite the observed negative impact on polio vaccination coverage at the onset of the COVID-19 pandemic, these rates gradually recovered, reaching 98.2% in primary vaccination in 2022. Over the past decade, two essential elements have been identified to maintain the goal of polio elimination and that reinforces the importance of sustaining high vaccination coverage: robust epidemiological surveillance systems and a swift response to alerts to protect the vulnerable population and prevent virus reintroduction...
March 27, 2024: Revista Española de Salud Pública
https://read.qxmd.com/read/38533525/towards-an-ai-driven-soft-toy-for-automatically-detecting-and-classifying-infant-toy-interactions-using-optical-force-sensors
#14
JOURNAL ARTICLE
Rithwik Udayagiri, Jessica Yin, Xinyao Cai, William Townsend, Varun Trivedi, Rohan Shende, O Francis Sowande, Laura A Prosser, James H Pikul, Michelle J Johnson
Introduction: It is crucial to identify neurodevelopmental disorders in infants early on for timely intervention to improve their long-term outcomes. Combining natural play with quantitative measurements of developmental milestones can be an effective way to swiftly and efficiently detect infants who are at risk of neurodevelopmental delays. Clinical studies have established differences in toy interaction behaviors between full-term infants and pre-term infants who are at risk for cerebral palsy and other developmental disorders...
2024: Frontiers in Robotics and AI
https://read.qxmd.com/read/38531587/challenges-and-lessons-learned-from-a-long-term-postauthorisation-safety-study-programme-of-rivaroxaban-in-europe
#15
REVIEW
Gunnar Brobert, Ana Ruigomez, Tania Schink, Annemarie Voss, Ron Herings, Elisabeth Smits, Karin M A Swart, Leif Friberg, Yanina Balabanova, Christine Tarenz, Kiliana Suzart-Woischnik, Montse Soriano-Gabarró, Pareen Vora, Martin Homering, Tomasz Dyszynski, Gerd Nagel, Pablo Amaya, Luis Alberto García Rodríguez
OBJECTIVES: To describe opportunities and challenges experienced from the four pharmacoepidemiological database studies included in the rivaroxaban post authorisation safety study (PASS) programme and propose ways to maximise the value of population-based observational research when addressing regulatory requirements. DESIGN: PASS programme of rivaroxaban carried out as part of the regulatory postapproval commitment to the European Medicines Agency. SETTING: Clinical practice in Germany, the Netherlands, Sweden and the UK (electronic health records)-undertaken by pharmacoepidemiology research teams using country-specific databases with different coding structures...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531385/milestone-operations-in-heart-valve-and-aortic-replacement-anniversaries-worth-remembering
#16
JOURNAL ARTICLE
Uberto Bortolotti, Igor Vendramin, Aldo D Milano, Ugolino Livi
Seventy years ago, in 1952, Charles A. Hufnagel implanted a caged-ball prosthesis into the descending thoracic aorta, to treat a patient with aortic valve insufficiency. In 1962, 60 years ago, the first aortic homograft was implanted in a subcoronary position by Donald N. Ross and Brian G. Barratt-Boyes. Forty years ago, in 1982, the first anticalcification treatment was introduced in commercially manufactured porcine bioprostheses. All such important or even milestone events should be remembered, since they witness efforts made by those who have significantly influenced the clinical history of aortic and valvular diseases...
March 26, 2024: Aorta (Stamford, Conn.)
https://read.qxmd.com/read/38531368/achieving-universal-social-protection-for-people-with-tuberculosis
#17
REVIEW
Ahmad Fuady, Thea Hutanamon, Olivia Herlinda, Nurul Luntungan, Tom Wingfield
As we mark World TB Day 2024, we take this opportunity to reflect on the 2023 UN General Assembly High-Level Meeting (HLM) on the fight against tuberculosis-a milestone in the commitment towards a more coordinated, comprehensive approach to end tuberculosis globally. The UN HLM declaration on the fight against tuberculosis includes a specific pledge that all people with tuberculosis should receive a social benefits package to mitigate financial hardship. However, it is not known how this specific pledge will be realised and through which concrete actions...
March 22, 2024: Lancet. Public Health
https://read.qxmd.com/read/38530077/building-synthetic-cells%C3%A2-from-the-technology-infrastructure-to-cellular-entities
#18
REVIEW
Lynn J Rothschild, Nils J H Averesch, Elizabeth A Strychalski, Felix Moser, John I Glass, Rolando Cruz Perez, Ibrahim O Yekinni, Brooke Rothschild-Mancinelli, Garrett A Roberts Kingman, Feilun Wu, Jorik Waeterschoot, Ion A Ioannou, Michael C Jewett, Allen P Liu, Vincent Noireaux, Carlise Sorenson, Katarzyna P Adamala
The de novo construction of a living organism is a compelling vision. Despite the astonishing technologies developed to modify living cells, building a functioning cell "from scratch" has yet to be accomplished. The pursuit of this goal alone has─and will─yield scientific insights affecting fields as diverse as cell biology, biotechnology, medicine, and astrobiology. Multiple approaches have aimed to create biochemical systems manifesting common characteristics of life, such as compartmentalization, metabolism, and replication and the derived features, evolution, responsiveness to stimuli, and directed movement...
March 26, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38528815/an-approach-to-the-milestones-of-spine-surgery-in-persian-traditional-medicine
#19
REVIEW
Azam Khosravi, Robrecht Van Hee, Mohammad Hossein Asadi, Saeed Amini, Aidin Shakeri, Saeed Changizi-Ashtiyani
BACKGROUND: The diagnosis and treatment of spine disorders have been challenging for thousands of years in different nations and medical schools. Despite this long history, there are many information gaps in this regard. The current research deals with the milestones and progress of spine surgery from ancient times until now, emphasizing the innovations of sages in the Persian traditional medicine era. METHODS: The present study is based on searching original and library documents, data from databases such as PubMed, Scopus, and Science Direct, and search engines such as Google Scholar...
March 26, 2024: Acta Chirurgica Belgica
https://read.qxmd.com/read/38528310/danicopan-first-approval
#20
REVIEW
Connie Kang
Danicopan (Voydeya® ) is an oral complement factor D inhibitor that is being developed by Alexion AstraZeneca Rare Disease as add-on treatment to ravulizumab or eculizumab for patients with clinically significant extravascular haemolysis. Danicopan recently received approval in Japan for the treatment of adults with paroxysmal nocturnal haemoglobinuria (PNH) when used in addition to a complement component 5 (C5) inhibitor. Subsequently, the European Medicines Agency adopted a positive opinion recommending the granting of marketing authorisation for danicopan for the treatment of patients with PNH who continue to have residual haemolytic anaemia despite treatment with a complement C5 inhibitor...
March 26, 2024: Drugs
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