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https://www.readbyqxmd.com/read/28633074/programming-cells-for-cardiac-repair
#1
REVIEW
Rocco Romagnuolo, Michael A Laflamme
Because the heart is a poorly regenerative organ, there has been considerable interest in developing novel cell-based approaches to restore lost contractile function after myocardial infarction (MI). While a wide variety of candidate cell types have been tested in animal MI models, the vast majority of clinical trials have used adult stem cell types, usually derived from bone marrow. These studies have generally yielded disappointing results, an outcome that may reflect in part the limited cardiogenic potential of the adult stem cell sources employed...
June 17, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28628551/a-clinical-framework-for-functional-recovery-in-a-person-with-chronic-traumatic-brain-injury-a-case-study
#2
Karen McCain, Staci Shearin
BACKGROUND AND PURPOSE: This case study describes a task-specific training program for gait walking and functional recovery in a young man with severe chronic traumatic brain injury. CASE DESCRIPTION: The individual was a 26-year-old man 4 years post-traumatic brain injury with severe motor impairments who had not walked outside of therapy since his injury. He had received extensive gait training prior to initiation of services. His goal was to recover the ability to walk...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28628249/defining-a-temporal-order-of-genetic-requirements-for-development-of-mycobacterial-biofilms
#3
Yong Yang, Joseph Thomas, Yunlong Li, Catherine Vilchèze, Keith M Derbyshire, William R Jacobs, Anil K Ojha
Most mycobacterial species spontaneously form biofilms, inducing unique growth physiologies and reducing drug sensitivity. Biofilm growth progresses through three genetically programmed stages: substratum attachment, intercellular aggregation and architecture maturation. Growth of Mycobacterium smegmatis biofilms requires multiple factors including a chaperonin (GroEL1) and a nucleoid-associated protein (Lsr2), although how their activities are linked remains unclear. Here we show that Lsr2 participates in intercellular aggregation, but substratum attachment of Lsr2 mutants is unaffected, thereby genetically distinguishing these developmental stages...
June 19, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28628017/-combined-immunotherapy-of-reconditional-chronic-non-specific-vulvovaginitis-in-immunocompromised-girls
#4
I Nesterova, S Kovaleva, G Chudilova, L Lomtatidze, V Krutova, I Aslanian, A Tulendinova, V Malinovskaya
Nonspecific chronic vulvovaginitis (CNV) is often a clinical indicator of immune deficiency, especially in young girls. The established violations of the functioning of various parts of the immune system (IS) in this pathology dictate the need to include in the complex of immunomodulatory therapy. The developed program of combined immunotherapy for immunocompromised girls allows to reduce the severity and duration of exacerbation of CNV, their frequency against the background of a significant reduction in the incidence of ARVI...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28624766/dhea-protects-mitochondria-against-dual-modes-of-apoptosis-and-necroptosis-in-human-granulosa-ho23-cells
#5
Kuan-Hao Tsui, Peng-Hui Wang, Li-Te Lin, Chia-Jung Li
Because ovarian granulosa cells are essential for oocyte maturation and development, we validated human granulosa HO23 cells to evaluate the ability of the DHEA to prevent cell death after starvation. The present study was aimed to investigate whether DHEA could protect against starvation-induced apoptosis and necroptosis in human oocyte granulosa HO23 cells. The starvation was induced by treatment of serum-free (SF) medium for 4 h in vitro Starvation-induced mitochondrial depolarization, cytochrome c release and caspase-3 activation were largely prevented by DHEA in HO23 cells...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28622295/high-autophagic-flux-guards-esc-identity-through-coordinating-autophagy-machinery-gene-program-by-foxo1
#6
Pinglei Liu, Kun Liu, Haifeng Gu, Weixu Wang, Jiaqi Gong, Yingjie Zhu, Qian Zhao, Jiani Cao, Chunseng Han, Fei Gao, Quan Chen, Wei Li, Jianwei Jiao, Baoyang Hu, Qi Zhou, Tongbiao Zhao
Although much is known about transcriptional networks that control embryonic stem cell (ESC) self-renewal and differentiation, the metabolic regulation of ESC is less clear. Autophagy is a catabolic process that is activated under both stress and normal conditions to degrade damaged organelles and aggregated proteins, and thus plays pivotal roles in somatic and adult stem cell function. However, if and how ESCs harness autophagy to regulate stemness remains largely unknown. Recently, we have defined that autophagy is essential for mitochondrial homeostasis regulation in pluripotency acquirement and maintenance...
June 16, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28622207/sleep-disturbance-as-a-precursor-of-severe-regression-in-kleefstra-syndrome-suggests-a-need-for-firm-and-rapid-pharmacological-treatment
#7
Karlijn Vermeulen, Wouter G Staal, Joost G Janzing, Hans van Bokhoven, Jos I M Egger, Tjitske Kleefstra
Intellectual disability is frequently accompanied by psychiatric symptoms that require pharmacological interventions. Treatment guidelines often provide a general treatment approach for these symptoms in intellectual disability. However, this may not always be the best strategy, as illustrated here in Kleefstra syndrome. We present 3 patients showing severe regression after sleep disturbances. If these are treated with care as usual (eg, behavioral programs and sleep medication) deterioration is likely to follow...
June 16, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28619687/use-of-the-central-sensitization-inventory-csi-as-a-treatment-outcome-measure-for-chronic-spinal-pain-disorder-patients-in-a-functional-restoration-program
#8
Randy Neblett, Meredith M Hartzell, Mark Williams, Kelley R Bevers, Tom G Mayer, Robert J Gatchel
BACKGROUND CONTEXT: The Central Sensitization Inventory (CSI) is a valid and reliable patient-reported instrument designed to identify patients whose presenting symptoms may be related to Central Sensitization (CS). Part A of the CSI measures a full array of 25 somatic and emotional symptoms associated with CS, and Part B asks if patients have previously been diagnosed with one or more specific Central Sensitivity Syndromes (CSSs) and related disorders. The CSI has previously been validated in a group of chronic pain patients who were screened by a trained psychiatrist for specific CSS diagnoses...
June 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28603517/the-effect-of-tgf-%C3%AE-on-treg-cells-in-adverse-pregnancy-outcome-upon-toxoplasma-gondii-infection
#9
Mingdong Zhao, Haixia Zhang, Xianbing Liu, Yuzhu Jiang, Liqin Ren, Xuemei Hu
Toxoplasma gondii (T. gondii) is a ubiquitous intracellular protozoan parasite that causes adverse pregnancy outcomes. Its infection downregulates the Treg cell population and TGF-β level, which may contribute to adverse pregnancy outcomes. TGF-β plays a critical role in Treg cell development, but whether TGF-β treatment can affect the number and function of Treg cells and hence alleviate adverse pregnancy outcomes caused by T. gondii infection remains elusive. In this study, T. gondii-infected pregnant mice were treated with TGF-β or TGF-β-neutralizing antibody...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28596336/regenerating-optic-pathways-from-the-eye-to-the-brain
#10
REVIEW
Bireswar Laha, Ben K Stafford, Andrew D Huberman
Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect the eyes to the brain, fail to regenerate after damage, eventually leading to blindness. Here, we review research on regeneration and repair of the optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC regeneration, and functional reformation of eye-to-brain connections is possible, even in the adult brain. Transplantation and gene therapy may serve to replace or resurrect dead or injured retinal neurons...
June 9, 2017: Science
https://www.readbyqxmd.com/read/28593101/dry-needling-increases-muscle-thickness-in-a-subject-with-persistent-muscle-dysfunction-a-case-report
#11
Kevin M Cross, Michael McMurray
BACKGROUND AND PURPOSE: Muscle dysfunction is very common following musculoskeletal injury. There is very little evidence to suggest that muscle function may be positively impacted by soft tissue interventions, such as dry needling. The purpose of this case report is to describe the immediate effect of dry needling on muscle thickness in a subject after shoulder surgery. CASE DESCRIPTION: A 22 year-old competitive gymnast presented seven months post shoulder surgery with significant impairments and functional limitations...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28576347/scapular-muscle-dysfunction-associated-with-subacromial-pain-syndrome
#12
Birgit Castelein, Barbara Cagnie, Ann Cools
STUDY DESIGN: Narrative Review. INTRODUCTION: One of the shoulder pain disorders in which the function of the scapula is comprised is the subacromial pain syndrome. Several rehabilitation guidelines and exercises have been proposed to improve scapulothoracic muscle dysfunction. Consideration of muscle activation patterns may help to select the most appropriate rehabilitation exercise in these patients. To date, suggesting rehabilitation exercises is often based upon the knowledge of the superficial lying scapulothoracic muscles' activity...
May 30, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28574587/stress-responsive-micrornas-are-involved-in-re-programming-of-metabolic-functions-in-hibernators
#13
REVIEW
Yasir Arfat, Chang Hui, Gao Yunfang
Mammalian hibernation includes re-programming of metabolic capacities, partially, encouraged by microRNAs (miRNAs). Albeit much is known about the functions of miRNAs, we need learning on low temperature miRNAs target determination. As hibernators can withstand low body temperatures (TB) for a long time without anguish tissue damage, understanding the means and mechanisms that empower them to do as such are of restorative intrigue. Nonetheless, these mechanisms by which miRNAs and the hibernators react to stressful conditions are not much clear...
June 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28572444/protein-malnutrition-blunts-the-increment-of-taurine-transporter-expression-by-a-high-fat-diet-and-impairs-taurine-reestablishment-of-insulin-secretion
#14
Renato Chaves Souto Branco, Rafael Ludemann Camargo, Thiago Martins Batista, Jean Franciesco Vettorazzi, Patrícia Cristine Borck, Junia Carolina Rebelo Dos Santos-Silva, Antonio Carlos Boschero, Cláudio Cesar Zoppi, Everardo Magalhães Carneiro
Taurine (TAU) restores β-cell function in obesity; however, its action is lost in malnourished obese rodents. Here, we investigated the mechanisms involved in the lack of effects of TAU in this model. C57BL/6 mice were fed a control diet (CD) (14% protein) or a protein-restricted diet (RD) (6% protein) for 6 wk. Afterward, mice received a high-fat diet (HFD) for 8 wk [CD + HFD (CH) and RD + HFD (RH)] with or without 5% TAU supplementation after weaning on their drinking water [CH + taurine (CHT) and RH + taurine (RHT)]...
June 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28572420/partial-ceramic-crowns-prepared-by-dental-students-clinical-performance-up-to-five-years
#15
Julia Bühler, Marina Alena Naef, Mauro Amato, Gabriel Krastl, Roland Weiger, Nicola Ursula Zitzmann
Partial ceramic crowns (PCCs) are an accepted treatment option for the restoration of posterior teeth with deficient tooth substance. Data on the survival of PCCs fabricated by dental students are scarce. The aim of this retrospective clinical study was to investigate the clinical performance and longevity of PCCs placed by dental students in the last year of their training program at the University of Basel, Switzerland. Eighty-eight patients who had received at least one PCC (n=108) in the program were considered for clinical assessment; their records were analyzed to detect previous complications or failures; and they were contacted by telephone...
June 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28571578/immunotherapy-in-head-and-neck-cancer-aiming-at-extreme-precision
#16
Petr Szturz, Jan B Vermorken
BACKGROUND: Locoregionally advanced, recurrent, and metastatic squamous cell carcinomas of the head and neck (SCCHN) remain difficult to treat disease entities, in which systemic treatment often forms an integral part of their management. Immunotherapy is based on functional restoration of the host immune system, helping to counteract various tumour evasion strategies. Broadly, immunotherapeutic approaches encompass tumour-specific antibodies, cancer vaccines, cytokines, adoptive T-cell transfer, and immune-modulating agents...
June 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28571034/remotely-programmed-deep-brain-stimulation-of-the-bilateral-subthalamic-nucleus-for-the-treatment-of-primary-parkinson-disease-a-randomized-controlled-trial-investigating-the-safety-and-efficacy-of-a-novel-deep-brain-stimulation-system
#17
Dianyou Li, Chencheng Zhang, Judith Gault, Wei Wang, Jianmin Liu, Ming Shao, Yanyan Zhao, Kristina Zeljic, Guodong Gao, Bomin Sun
BACKGROUND: Deep brain stimulation (DBS) is the most commonly performed surgery for the debilitating symptoms of Parkinson disease (PD). However, DBS systems remain largely unaffordable to patients in developing countries, warranting the development of a safe, economically viable, and functionally comparable alternative. OBJECTIVE: To investigate the efficacy and safety of wirelessly programmed DBS of bilateral subthalamic nucleus (STN) in patients with primary PD...
June 2, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28562674/how-does-functionality-proceed-in-acl-reconstructed-subjects-proceeding-of-functional-performance-from-pre-to-six-months-post-acl-reconstruction
#18
Frieder Cornelius Krafft, Bernd Josef Stetter, Thorsten Stein, Andree Ellermann, Johannes Flechtenmacher, Christian Eberle, Stefan Sell, Wolfgang Potthast
This is the first study examining functionality of subjects with anterior cruciate ligament (ACL) tears and a subsequent reconstruction comprehensively by multiple test sessions from pre- to six months post-reconstruction. The purpose was to evaluate if a generally applied rehabilitation program restores functionality to levels of healthy controls. Subjects with unilateral tears of the ACL were compared to matched healthy controls throughout the rehabilitation. 20 recreational athletes were tested: T1 (preoperative), 6 weeks after tear; T2, 6 weeks, T3, 3 months, T4, 6 months post-reconstruction...
2017: PloS One
https://www.readbyqxmd.com/read/28552492/age-associated-loss-of-opa1-in-muscle-impacts-muscle-mass-metabolic-homeostasis-systemic-inflammation-and-epithelial-senescence
#19
Caterina Tezze, Vanina Romanello, Maria Andrea Desbats, Gian Paolo Fadini, Mattia Albiero, Giulia Favaro, Stefano Ciciliot, Maria Eugenia Soriano, Valeria Morbidoni, Cristina Cerqua, Stefan Loefler, Helmut Kern, Claudio Franceschi, Stefano Salvioli, Maria Conte, Bert Blaauw, Sandra Zampieri, Leonardo Salviati, Luca Scorrano, Marco Sandri
Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss. In adult mice, acute, muscle-specific deletion of Opa1 induces a precocious senescence phenotype and premature death. Conditional and inducible Opa1 deletion alters mitochondrial morphology and function but not DNA content. Mechanistically, the ablation of Opa1 leads to ER stress, which signals via the unfolded protein response (UPR) and FoxOs, inducing a catabolic program of muscle loss and systemic aging...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28550417/motivational-interviewing-for-workers-with-disabling-musculoskeletal-disorders-results-of-a-cluster-randomized-control-trial
#20
Joanne Park, Shaniff Esmail, Fahreen Rayani, Colleen M Norris, Douglas P Gross
Purpose Although functional restoration programs appear effective in assisting injured workers to return-to-work (RTW) after a work related musculoskeletal (MSK) disorder, the addition of Motivational Interviewing (MI) to these programs may result in higher RTW. Methods We conducted a cluster randomized controlled trial with claimants attending an occupational rehabilitation facility from November 17, 2014 to June 30, 2015. Six clinicians provided MI in addition to the standard functional restoration program and formed an intervention group...
May 26, 2017: Journal of Occupational Rehabilitation
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