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https://www.readbyqxmd.com/read/29655527/the-smiling-scan-technique-facially-driven-guided-surgery-and-prosthetics
#1
Alessandro Pozzi, Lorenzo Arcuri, Peter K Moy
PURPOSE: To introduce a proof of concept technique and new integrated workflow to optimize the functional and esthetic outcome of the implant-supported restorations by means of a 3-dimensional (3D) facially-driven, digital assisted treatment plan. METHODS: The Smiling Scan technique permits the creation of a virtual dental patient (VDP) showing a broad smile under static conditions. The patient is exposed to a cone beam computed tomography scan (CBCT), displaying a broad smile for the duration of the examination...
April 11, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29650034/complex-fracture-orthopedic-rehabilitation-comfort-real-time-visual-biofeedback-on-weight-bearing-versus-standard-training-methods-in-the-treatment-of-proximal-femur-fractures-in-the-elderly-study-protocol-for-a-multicenter-randomized-controlled-trial
#2
Marco Raaben, Syaiful Redzwan, Robin Augustine, Taco Johan Blokhuis
BACKGROUND: Proximal femur fractures are a common injury after low energy trauma in the elderly. Most rehabilitation programs are based on restoring mobility and early resumption of weight-bearing. However, therapy compliance is low in patients following lower extremity fractures. Moreover, little is known about the relevance of gait parameters and how to steer the rehabilitation after proximal femur fractures in the elderly. Therefore, the aim of this prospective, randomized controlled trial is to gain insight in gait parameters and evaluate if real-time visual biofeedback can improve therapy compliance after proximal femur fractures in the elderly...
April 12, 2018: Trials
https://www.readbyqxmd.com/read/29628307/a-stress-response-that-monitors-and-regulates-mrna-structure-is-central-to-cold-shock-adaptation
#3
Yan Zhang, David H Burkhardt, Silvi Rouskin, Gene-Wei Li, Jonathan S Weissman, Carol A Gross
Temperature influences the structural and functional properties of cellular components, necessitating stress responses to restore homeostasis following temperature shift. Whereas the circuitry controlling the heat shock response is well understood, that controlling the E. coli cold shock adaptation program is not. We found that during the growth arrest phase (acclimation) that follows shift to low temperature, protein synthesis increases, and open reading frame (ORF)-wide mRNA secondary structure decreases...
April 2, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29615718/genetic-abrogation-of-immune-checkpoints-in-antigen-specific-cytotoxic-t-lymphocyte-as-a-potential-alternative-to-blockade-immunotherapy
#4
Chi Zhang, Yanchun Peng, Philip Hublitz, Haokang Zhang, Tao Dong
T cell function can be compromised during chronic infections or through continuous exposure to tumor antigens by the action of immune checkpoint receptors, such as programmed cell death protein 1 (PD-1). Systemic administration of blocking antibodies against the PD-1 pathway can restore T cell function, and has been approved for the treatment of several malignancies, although there is a risk of adverse immune-related side-effects. We have developed a method for generating gene knockouts in human antigen (Ag)-specific cytotoxic T-Lymphocyte (CTLs) using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29607506/music-supported-therapy-in-the-rehabilitation-of-subacute-stroke-patients-a-randomized-controlled-trial
#5
Jennifer Grau-Sánchez, Esther Duarte, Neus Ramos-Escobar, Joanna Sierpowska, Nohora Rueda, Susana Redón, Misericordia Veciana de Las Heras, Jordi Pedro, Teppo Särkämö, Antoni Rodríguez-Fornells
The effect of music-supported therapy (MST) as a tool to restore hemiparesis of the upper extremity after a stroke has not been appropriately contrasted with conventional therapy. The aim of this trial was to test the effectiveness of adding MST to a standard rehabilitation program in subacute stroke patients. A randomized controlled trial was conducted in which patients were randomized to MST or conventional therapy in addition to the rehabilitation program. The intensity and duration of the interventions were equated in both groups...
April 1, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29600688/early-robot-assisted-gait-retraining-in-non-ambulatory-patients-with-stroke-a-single-blind-randomized-controlled-trial
#6
Andreas Mayr, Ellen Quirbach, Alessandro Picelli, Markus Kofler, Nicola Smania, Leopold Saltuari
BACKGROUND: Restoration of walking function is a primary concern of neurorehabilitation with respect to the aspired social and vocational reintegration. To date, the best practice for improving gait early after stroke is still object of debate. On one hand, repetitive task-specific approaches with higher intensities of walking have been observed to result in greater improvements of gait after stroke. Conversely there is some evidence that conventional gait training would be more effective for facilitating walking ability after stroke...
March 29, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29581579/restoration-of-e-cadherin-by-ppbica-protects-against-cisplatin-induced-acute-kidney-injury-by-attenuating-inflammation-and-programmed-cell-death
#7
Li Gao, Ming-Ming Liu, Hong-Mei Zang, Qiu-Ying Ma, Qin Yang, Ling Jiang, Gui-Ling Ren, Hai-Di Li, Wei-Feng Wu, Jia-Nan Wang, Biao Wei, Xue-Qi Liu, Cheng Jiang, Cheng Huang, Jun Li, Xiao-Ming Meng
E-cadherin is a major component of tubular adherent proteins that maintain intercellular contacts and cell polarity in epithelial tissue. It is involved in pathological processes of renal cell carcinoma and fibrotic diseases via epithelial-mesenchymal transition. Although studies have shown E-cadherin is significantly downregulated in acute kidney injury (AKI), its function in AKI is unknown. Here, we evaluated cell damage and inflammation in cisplatin-stimulated tubular epithelial cell lines after disrupting E-cadherin and restoring it with PPBICA, a small molecule identified by high-throughput screening...
March 26, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29576644/complex-tibial-plateau-fractures-treated-by-hybrid-external-fixation-system-a-correlation-of-followup-computed-tomography-derived-quality-of-reduction-with-clinical-results
#8
Konstantinos Kateros, Spyridon P Galanakos, Georgios Kyriakopoulos, Stamatios A Papadakis, George A Macheras
Background: Tibial plateau fractures are common due to high energy injuries. The principles of treatment include respect for the soft tissues, restoring the congruity of the articular surface and reduction of the anatomic alignment of the lower limb to enable early movement of the knee joint. There are various surgical fixation methods that can achieve these principles of treatment. Recognition of the particular fracture pattern is important, as this guides the surgical approach required in order to adequately stabilize the fracture...
March 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29576222/blocking-tim-3-or-and-pd-1-reverses-dysfunction-of-tumor-infiltrating-lymphocytes-in-hbv-related-hepatocellular-carcinoma
#9
Furong Liu, Gucheng Zeng, Shaotang Zhou, Xiaoshun He, Nianfeng Sun, Xiaofeng Zhu, Anbin Hu
BACKGROUND: The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC. METHODS: Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study...
March 22, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29559341/biosynthesis-of-d-series-resolvins-in-skin-provides-insights-into-their-role-in-tissue-repair
#10
Jason Hellmann, Brian E Sansbury, Blenda Wong, Xiaofeng Li, Mansher Singh, Kristo Nuutila, Nan Chiang, Elof Eriksson, Charles N Serhan, Matthew Spite
Cutaneous injury causes underlying tissue damage that must be quickly repaired to minimize exposure to pathogens and to restore barrier function. While the role of growth factors in tissue repair is established, the role of lipid mediators in skin repair has not been extensively investigated. Using a mass spectrometry-based lipid mediator metabolomics approach, we identified D-series resolvins and related pro-resolving lipid mediators during skin injury in mice and pigs. Differentiation of human epidermal keratinocytes increased expression of 15-lipoxygenase and stereospecific production of 17S-hydroxydocosahexaenoic acid, the common upstream biosynthetic marker and precursor of D-series resolvins...
March 17, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29550614/synthetic-biology-in-probiotic-lactic-acid-bacteria-at-the-frontier-of-living-therapeutics
#11
REVIEW
Zachary Js Mays, Nikhil U Nair
The trillions of microbes hosted by humans can dictate health or illness depending on a multitude of genetic, environmental, and lifestyle factors that help define the human ecosystem. As the human microbiota is characterized, so can the interconnectivity of microbe-host-disease be realized and manipulated. Designing microbes as therapeutic agents can not only enable targeted drug delivery but also restore homeostasis within a perturbed microbial community. Used for centuries in fermentation and preservation of food, lactic acid bacteria (LAB) have a long history of safe, and occasionally health promoting, interactions with the human gut, making them ideal candidates for engineered functionality...
March 15, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29547017/return-to-work-after-rehabilitation-in-chronic-low-back-pain-workers-does-the-interprofessional-collaboration-work
#12
Clotilde Michel, Vincent Guêné, Eliane Michon, Yves Roquelaure, Audrey Petit
The objective of this study was to assess the workplace information collected and shared between professionals of the centers and occupational health professionals during functional restoration programs intended to chronic low back pain patients. A descriptive study carried out by a questionnaire sent to the French rehabilitation centers offering a functional restoration program. Data collection focused on the kinds of professionals involved in programs, professionals who approach work issues, work analysis, social and occupational information collected, existence of a specific work rehabilitation program, frequency of and methods for sharing information with occupational health professionals...
March 16, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29546444/dissecting-the-genetic-basis-of-heavy-panicle-hybrid-rice-uncovered-gn1a-and-gs3-as-key-genes
#13
Shiguang Wang, Bingtian Ma, Qiang Gao, Guojing Jiang, Lei Zhou, Bin Tu, Peng Qin, Xueqin Tan, Peixiong Liu, Yunhai Kang, Yuping Wang, Weilan Chen, Chengzhi Liang, Shigui Li
Shuhui498 (R498) is an elite parent of heavy panicle hybrid rice by pyramiding the rare gn1a and null gs3 alleles. This finding reveals the genetic basis and great potential application in future breeding of R498. The heavy panicle trait, defined as 5 g or more of grain weight per panicle, is one of the target traits in super-high-yield rice breeding programs. The use of heavy panicle-type hybrid rice has been shown to be a successful strategy for super-high-yield breeding programs, particularly under the environmental conditions of high humidity and deficient solar radiation in southwestern China...
March 15, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29540833/off-and-back-on-again-a-tumor-suppressor-s-tale
#14
REVIEW
Jonuelle Acosta, Walter Wang, David M Feldser
Tumor suppressor genes play critical roles orchestrating anti-cancer programs that are both context dependent and mechanistically diverse. Beyond canonical tumor suppressive programs that control cell division, cell death, and genome stability, unexpected tumor suppressor gene activities that regulate metabolism, immune surveillance, the epigenetic landscape, and others have recently emerged. This diversity underscores the important roles these genes play in maintaining cellular homeostasis to suppress cancer initiation and progression, but also highlights a tremendous challenge in discerning precise context-specific programs of tumor suppression controlled by a given tumor suppressor...
March 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29537370/modulation-of-prdm9-controlled-meiotic-chromosome-asynapsis-overrides-hybrid-sterility-in-mice
#15
Sona Gregorova, Vaclav Gergelits, Irena Chvatalova, Tanmoy Bhattacharyya, Barbora Valiskova, Vladana Fotopulosova, Petr Jansa, Diana Wiatrowska, Jiri Forejt
Hybrid sterility is one of the reproductive isolation mechanisms leading to speciation. Prdm9 , the only known vertebrate hybrid sterility gene, causes failure of meiotic chromosome synapsis and infertility in male hybrids between two mouse subspecies. But within species Prdm9 determines the sites of programmed DNA double-strand breaks and meiotic recombination hotspots. To investigate the relation between Prdm9 -controlled meiotic arrest and asynapsis, we inserted random stretches of consubspecific homology on several autosomal pairs in sterile hybrids and analyzed their ability to form synaptonemal complexes and rescue male fertility...
March 14, 2018: ELife
https://www.readbyqxmd.com/read/29523133/obesity-as-disruptor-of-the-female-fertility
#16
REVIEW
Erica Silvestris, Giovanni de Pergola, Raffaele Rosania, Giuseppe Loverro
Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the 'hypothalamic pituitary ovarian axis', and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation...
March 9, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29514911/a-stem-loop-structure-in-potato-leafroll-virus-orf5-that-is-essential-for-readthrough-translation-of-the-coat-protein-orf-stop-codon-700-bases-upstream
#17
Yi Xu, Ho Jung Ju, S DeBlasio, Elizabeth J Carino, R Johnson, M MacCoss, M Cilia Heck, W Allen Miller, S M Gray
Translational readthrough of the stop codon of the capsid protein (CP) open reading frame (ORF) is used by members of the Luteoviridae to produce their minor capsid protein as a readthrough protein (RTP). The elements regulating RTP expression are not well understood, but involve long-distance interactions between RNA domains. Using high-resolution mass spectrometry, glutamine and tyrosine were identified as the primary amino acids inserted at the stop codon of Potato leafroll virus (PLRV) CP ORF. We characterized the contributions of a cytidine-rich domain immediately downstream, and a branched stem-loop structure 600-700 nucleotides downstream of the CP stop codon...
March 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29507905/pyrroloquinoline-quinone-prevents-developmental-programming-of-microbial-dysbiosis-and-macrophage-polarization-to-attenuate-liver-fibrosis-in-offspring-of-obese-mice
#18
Jacob E Friedman, Evgenia Dobrinskikh, Alba Alfonso-Garcia, Alexander Fast, Rachel C Janssen, Taylor K Soderborg, Aimee L Anderson, Julie A Reisz, Angelo D'Alessandro, Daniel N Frank, Charles E Robertson, Becky A de la Houssaye, Linda K Johnson, David J Orlicky, Xiaoxin X Wang, Moshe Levi, Eric O Potma, Karim C El Kasmi, Karen R Jonscher
Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment in utero , exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to development of fatty liver disease. We found that exposure to a maternal Western-style diet (WD) accelerated fibrogenesis in the liver of offspring and was associated with early recruitment of proinflammatory macrophages at 8-12 weeks and microbial dysbiosis as early as 3 weeks of age...
March 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29502955/the-ss18-ssx-oncoprotein-hijacks-kdm2b-prc1-1-to-drive-synovial-sarcoma
#19
Ana Banito, Xiang Li, Aimée N Laporte, Jae-Seok Roe, Francisco Sanchez-Vega, Chun-Hao Huang, Amanda R Dancsok, Katerina Hatzi, Chi-Chao Chen, Darjus F Tschaharganeh, Rohit Chandwani, Nilgun Tasdemir, Kevin B Jones, Mario R Capecchi, Christopher R Vakoc, Nikolaus Schultz, Marc Ladanyi, Torsten O Nielsen, Scott W Lowe
Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX (SSX1 or SSX2) transcriptional repressor. Using functional genomics, we identify KDM2B, a histone demethylase and component of a non-canonical polycomb repressive complex 1 (PRC1.1), as selectively required for sustaining synovial sarcoma cell transformation. SS18-SSX1 physically interacts with PRC1.1 and co-associates with SWI/SNF and KDM2B complexes on unmethylated CpG islands...
February 22, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29502464/the-effect-of-trunk-training-on-muscle-thickness-and-muscle-activity-a-systematic-review
#20
Tamaya Van Criekinge, Steven Truijen, Chelsea Verbruggen, Lotte Van de Venis, Wim Saeys
OBJECTIVE: A systematic review to examine the effect of static or dynamic trunk training compared to standard care or control therapy on muscle activity and muscle thickness of the trunk and lower limb muscles in stroke survivors. MATERIALS AND METHODS: This review was registered on PROSPERO (no: CRD42017063771) and was written according to the PRISMA guidelines. The search strategy included studies from the first indexed article until September 2017 and was performed in the electronical databases PubMed, Web of Science, Cochrane Library, Ovid Medline and PEDro...
March 5, 2018: Disability and Rehabilitation
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