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functional restoration program

Andrew J Hahne, Jon J Ford, Rana S Hinman, Matthew C Richards, Luke D Surkitt, Alexander Yp Chan, Sarah L Slater, Nicholas F Taylor
BACKGROUND CONTEXT: Physical therapy is commonly sought by people with lumbar disc herniation and associated radiculopathy. It is unclear whether physical therapy is effective for this population. PURPOSE: To determine the effectiveness of physical therapist delivered individualized functional restoration as an adjunct to guideline-based advice in people with lumbar disc herniation and associated radiculopathy. DESIGN: Pre-planned subgroup analysis of a multicenter parallel group randomized controlled trial...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
Soung Min Kim, Emmanuel K Amponsah, Hui Young Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee
: Ameloblastoma is the most common benign odontogenic tumor of the jaw, and expansional growth of a huge untreated ameloblastoma can result in disturbances in facial aesthetics and function, such as difficulty with mouth opening, swallowing, chewing, breathing, neurologic deficits, and pathologic fractures. Radical wide resection with safety margins and subsequent reconstruction is generally recommended. A fibular free flap (FFF) is commonly used to reconstruct the mandible in order to adequately restore both aesthetic appearance and function...
September 2016: Ghana Medical Journal
Yong Yu, Jason C H Tsang, Cui Wang, Simon Clare, Juexuan Wang, Xi Chen, Cordelia Brandt, Leanne Kane, Lia S Campos, Liming Lu, Gabrielle T Belz, Andrew N J McKenzie, Sarah A Teichmann, Gordon Dougan, Pentao Liu
Innate lymphoid cells (ILCs) functionally resemble T lymphocytes in cytotoxicity and cytokine production but lack antigen-specific receptors, and are important regulators in immune response and tissue homeostasis(1, 2). ILCs are generated from common lymphoid progenitors (CLPs), which are subsequently committed to innate lymphoid lineages in the α lymphoid progenitor (αLP), early innate lymphoid progenitor (EILP), common helper innate lymphoid progenitor (CHILP) and innate lymphoid cell progenitor (ILCP) compartments(3, 4, 5, 6, 7, 8)...
September 29, 2016: Nature
Huaizhou Wang, Beiying Wu, Lei Li, Liang Hu, Jiafei Lin, Cen Jiang, Gang Cai, Qian Shen
Similar to programmed death-1 (PD-1), B and T lymphocyte attenuator (BTLA) is a co-inhibitory molecule of the CD28 family. PD-1 is involved in T cell exhaustion during chronic viral infection. However, the role of BTLA in virus-specific T cells is poorly defined. Here we investigated the expression and function of BTLA in T cells from patients with chronic hepatitis B virus (HBV) infection. The phenotype of peripheral and intrahepatic HBV-specific T cells from 43 patients with chronic HBV infection was assessed by flow cytometry...
October 6, 2016: Cellular Immunology
Caroline Stienne, Michaël F Michieletto, Mehdi Benamar, Nadège Carrié, Isabelle Bernard, Xuan-Hung Nguyen, Yannick Lippi, Fanny Duguet, Roland S Liblau, Stephen M Hedrick, Abdelhadi Saoudi, Anne S Dejean
The transcription factor Foxo3 plays a crucial role in myeloid cell function but its role in lymphoid cells remains poorly defined. Here, we have shown that Foxo3 expression was increased after T cell receptor engagement and played a specific role in the polarization of CD4(+) T cells toward pathogenic T helper 1 (Th1) cells producing interferon-γ (IFN-γ) and granulocyte monocyte colony stimulating factor (GM-CSF). Consequently, Foxo3-deficient mice exhibited reduced susceptibility to experimental autoimmune encephalomyelitis...
October 1, 2016: Immunity
Emilio A Herrera, Francisca Cifuentes-Zúñiga, Esteban Figueroa, Cristian Villanueva, Cherie Hernández, René Alegría, Viviana Arroyo, Estefania Peñaloza, Marcelo Farías, Ricardo Uauy, Paola Casanello, Bernardo J Krause
In humans, intrauterine growth restriction (IUGR) is associated with vascular dysfunction, oxidative stress and signs of endothelial programming in umbilical vessels. We aimed to determine the effects of maternal antioxidant treatment with N-acetyl cysteine (NAC) on fetal endothelial function and eNOS programming in IUGR guinea pigs. IUGR was induced by implanting ameroid constrictors on uterine arteries of pregnant guinea pigs at mid gestation, receiving half of the sows NAC in the drinking water (from day 34 until term)...
October 14, 2016: Journal of Physiology
Jingtao Luo, Yun Hong, Xiaoan Tao, Xi Wei, Lun Zhang, Qiang Li
Unlike normal cells, cancer cells are recently identified to rely on aerobic glycolysis for energy production called the Warburg effect. Several attempts are being made to target this metabolic reprogramming pathway in treating cancers; however, the successful rate is very limited. In this study, we investigated the functional roles of fatty acid oxidation key enzyme carnitine palmitoyl transferase 1a (CPT-1a), during the metabolic programming of pancreatic ductal adenocarcinoma (PDAC) cells induced by glucose deprivation...
October 13, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Oskar C Aszmann, Ivan Vujaklija, Aidan D Roche, Stefan Salminger, Malvina Herceg, Agnes Sturma, Laura A Hruby, Anna Pittermann, Christian Hofer, Sebastian Amsuess, Dario Farina
Critical soft tissue injuries may lead to a non-functional and insensate limb. In these cases standard reconstructive techniques will not suffice to provide a useful outcome, and solutions outside the biological arena must be considered and offered to these patients. We propose a concept which, after all reconstructive options have been exhausted, involves an elective amputation along with a bionic substitution, implementing an actuated prosthetic hand via a structured tech-neuro-rehabilitation program. Here, three patients are presented in whom this concept has been successfully applied after mutilating hand injuries...
October 10, 2016: Scientific Reports
Abdullah A Gahzi, Dean S Elterman, Magdy Hassouna
The objective of this study was to describe our experience using sacral neuromodulation to treat urinary urgency, frequency, urge incontinence, and chronic urinary retention in patients with cardiac pacemakers. With the increasingly widespread use of InterStim for bladder function restoration, we are seeing more complex patients with multiple comorbidities, including cardiac conditions. Herein, we report 3 cases of individuals with cardiac pacemakers who underwent InterStim implantation to treat urinary conditions...
September 2016: International Neurourology Journal
Yiyuan Zhao, Benoit M Dawant, Jack H Noble
Cochlear implants (CIs) are neural prostheses that restore hearing by stimulating auditory nerve pathways within the cochlea using an implanted electrode array. Research has shown when multiple electrodes stimulate the same nerve pathways, competing stimulation occurs and hearing outcomes decline. Recent clinical studies have indicated that hearing outcomes can be significantly improved by using an image-guided active electrode set selection technique we have designed, in which electrodes that cause competing stimulation are identified and deactivated...
July 2016: Journal of Medical Imaging
Mohamed M Mira, Robert D Hill, Claudio Stasolla
Hypoxic root growth in maize is influenced by expression of phytoglobins (ZmPgbs). Relative to WT, suppression of ZmPgb1.1 or ZmPgb1.2 inhibits growth of roots exposed to 4% oxygen causing structural abnormalities in the root apical meristems. These effects were accompanied by increasing levels of reactive oxygen species (ROS), possibly through the transcriptional induction of four Respiratory Burst Oxidase Homologs (RBOHs). TUNEL-positive nuclei in meristematic cells indicated the involvement of programmed cell death (PCD) in the process...
October 4, 2016: Plant Physiology
Yuki Kuwano, Kensei Nishida, Yoko Akaike, Ken Kurokawa, Tatsuya Nishikawa, Kiyoshi Masuda, Kazuhito Rokutan
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis...
2016: International Journal of Molecular Sciences
Julien Nardoux
OBJECTIVE: Chronic low-back pain is accompanied by physical deconditioning which result among other by lower VO2max and by disturbances isokinetic explorations. The objective of this study was to investigate whether there was a correlation between VO2max and isokinetic parameters spine before and after a functional restoration program (FRP). MATERIAL/PATIENTS AND METHODS: Uni-centric retrospective study in routine care. Isokinetic spine muscle strength evaluation and functional exercise exploration were performed before and after FRP for all hospitalized patients for 4 weeks to FRP...
September 2016: Annals of Physical and Rehabilitation Medicine
Clémence Coll, Elsa Mauruc, Célia Valser, Luce Condamine, Emilie Hutin, Yves Coulomb, Jean-Michel Gracies, Shahab Fardjad
OBJECTIVE: The efficacy of multidisciplinary functional restoration spine programs (FRP) has been demonstrated in terms of secondary prevention in chronic low-back pain (LBP), working lumbar spine reconditioning. Our LBP patients follow a FRP program, one day/week over 5 weeks, with self-rehabilitation the other days called "mini FRP". The objective of the study is to compare responses to a mini-FRP program, between two groups from a population of patients working with LBP: "Sedentary Workers (SW)" and "Force Workers (FW)"...
September 2016: Annals of Physical and Rehabilitation Medicine
Jean-Pascal Devailly, Laurence Josse
OBJECTIVE: In all countries, the boundaries are ambiguous between acute and post-acute as well as defining the dimensions of care. The aim of this study is to analyze relations between segmentation of care and payment systems. In the new prospective payment system implemented in French SSR, the grouping unit is inpatient stay and the week for day hospitalization. In 1991, the field of SSR mixed structures as diverse in their purposes as public or private hospital units of rehabilitation and "nursing homes"...
September 2016: Annals of Physical and Rehabilitation Medicine
Mathilde Berger, Alessandro Farné, Karen Reilly, Emmanuelle Chaléat-Valayer
OBJECTIVE/INTRODUCTION: The body image refers to the conscious representation of our own body. It can be modulated by various sensory manipulations and can also be disturbed in people with chronic pain [1,2]. OBJECTIVE: The objective of this study is to assess the body image of people with chronic low back pain (CLBP) and its evolution after a functional restoration program (FRP). MATERIAL/PATIENTS AND METHODS: Prospective and single-center study, carried out on a population of people with CLBP receiving a FRP lasting four weeks...
September 2016: Annals of Physical and Rehabilitation Medicine
Joséphine Métréau, Frédéric Brogniart, Claude Grandjean, Bertrand Morineaux
OBJECTIVE: Postural balance is ensured by the involvement of several coping strategies. There is however an alteration of the proprioceptive system with chronic low back pain patients making it vulnerable to any type of disruptive force (endogenous and exogenous) and physiologically compensated by the postural system. The aim of this study is to measure the postural changes during a functional restoration protocol. MATERIAL/PATIENTS AND METHODS: Were included in this study, 8 chronic low back pain patients, seen in consultation before being included in the rehabilitative care unit of the Bourbonne-les-Bains Hospital as part of a functional restoration protocol for 5-6 weeks...
September 2016: Annals of Physical and Rehabilitation Medicine
François Segretin, Guillaume Paris, Sarah Cheriet, Yohann Delarue
OBJECTIVE: The chronic lateral epicondylitis is a common pathology with an economic impact. Actually, many costly therapies are prescribed without evidence of their effectiveness. Physical therapies seem to be neglected. However, they can correct actions at risk and involve the patient in his rehabilitation. MATERIAL/PATIENTS AND METHODS: This study evaluated the effectiveness of a standardized 2 month rehabilitation program composed of: an outpatient group education session, 18 liberal physical therapy sessions with correction of the posture of the trunk and shoulder, eccentric strengthening of the supinator muscles and the wrist extensor muscles, stretching, and some self daily exercises (transverse friction massage and stretching) according to Pernot-Comtet protocol...
September 2016: Annals of Physical and Rehabilitation Medicine
Andriani C Patera, Anne M Drewry, Katherine Chang, Evan R Beiter, Dale Osborne, Richard S Hotchkiss
Sepsis is a heterogeneous syndrome comprising a highly diverse and dynamic mixture of hyperinflammatory and compensatory anti-inflammatory immune responses. This immune phenotypic diversity highlights the importance of proper patient selection for treatment with the immunomodulatory drugs that are entering clinical trials. To better understand the serial changes in immunity of critically ill patients and to evaluate the potential efficacy of blocking key inhibitory pathways in sepsis, we undertook a broad phenotypic and functional analysis of innate and acquired immunity in the same aliquot of blood from septic, critically ill nonseptic, and healthy donors...
September 26, 2016: Journal of Leukocyte Biology
Jian Xiao, Xian Liu, Xiaolei Yu, Yuan Dong, Xuqin Wang, Jing Leng, Rongge Yang, Ying Wang
Objective To investigate the expressions of programmed death-1 (PD-1), CD38, human leukocyte antigen DR (HLA-DR) and anligen KI-67(ki67) on CD8(+) T cells, and the correlation between PD-1/PD-L1 pathway and activation, immunodepletion during HIV-1 infection. Methods Peripheral blood mononuclear cells were isolated by density gradient centrifugation from 87 HIV-1 patients and 22 healthy controls. The expression levels of PD-1, CD38, HLA-DR and ki67 on CD8(+)T cells were detected by flow cytometry. Furthermore, we evaluated the production of interferon-γ (IFN-γ) and tumor necrosis factor α (TNF-α) in CD8(+) T cells by blocking PD-1/PD-L1 pathway in the presence of PD-L1 mAb...
October 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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