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https://www.readbyqxmd.com/read/29470592/-treatment-after-anatomical-and-inverse-shoulder-tep
#1
REVIEW
M Farkhondeh Fal, J Kircher
Shoulder arthroplasties in specialized centers are routine procedures with an increasing number of operations in the developed countries. Restoration of pain free shoulder function requires an intensive, specific and individual rehabilitation program for each patient. There is a phase-like course with different specific demands and measures that extends over a period of several weeks. Return to sport and a pain free function for activities of daily living resulting in a high patient satisfaction can routinely be expected...
February 22, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29470250/clinically-oriented-device-programming-in-bradycardia-patients-part-1-sinus-node-disease-proposals-from-aiac-italian-association-of-arrhythmology-and-cardiac-pacing
#2
Matteo Ziacchi, Pietro Palmisano, Mauro Biffi, Renato P Ricci, Maurizio Landolina, Massimo Zoni-Berisso, Eraldo Occhetta, Giampiero Maglia, Gianluca Botto, Luigi Padeletti, Giuseppe Boriani
: Modern pacemakers have an increasing number of programable parameters and specific algorithms designed to optimize pacing therapy in relation to the individual characteristics of patients. When choosing the most appropriate pacemaker type and programing, the following variables must be taken into account: the type of bradyarrhythmia at the time of pacemaker implantation; the cardiac chamber requiring pacing, and the percentage of pacing actually needed to correct the rhythm disorder; the possible association of multiple rhythm disturbances and conduction diseases; the evolution of conduction disorders during follow-up...
February 20, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29467593/depletion-of-membrane-cholesterol-compromised-caspase-8-imparts-in-autophagy-induction-and-inhibition-of-cell-migration-in-cancer-cells
#3
Mukesh Kumar, Karuna Irungbam, Meena Kataria
Background: Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell death after cholesterol depletion than normal cells. Methyl-β-cyclodextrin (MβCD), an amphipathic polysaccharide known to deplete the membrane cholesterol, induces cell death selectively in cancer cells. Present work was designed to identify the major form of programmed cell death in membrane cholesterol depleted cancer cells (MDA-MB 231 and 4T1) and its impact on migration efficiency of cancer cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29467023/protracted-immune-disorders-at-one-year-after-icu-discharge-in-patients-with-septic-shock
#4
Florence Riché, Benjamin G Chousterman, Patrice Valleur, Alexandre Mebazaa, Jean-Marie Launay, Etienne Gayat
BACKGROUND: Sepsis is a leading cause of mortality and critical illness worldwide and is associated with an increased mortality rate in the months following hospital discharge. The occurrence of persistent or new organ dysfunction(s) after septic shock raises questions about the mechanisms involved in the post-sepsis status. The present study aimed to explore the immune profiles of patients one year after being discharged from the intensive care unit (ICU) following treatment for abdominal septic shock...
February 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29452352/conditional-ablation-and-conditional-rescue-models-for-casq2-elucidate-the-role-of-development-and-of-cell-type-specific-expression-of-casq2-in-the-cpvt2-phenotype
#5
Daniel J Flores, ThuyVy Duong, Luke O Brandenberger, Apratim Mitra, Aditya Shirali, John C Johnson, Danielle Springer, Audrey Noguchi, Zu-Xi Yu, Steven N Ebert, Andreas Ludwig, Bjorn C Knollmann, Mark D Levin, Karl Pfeifer
Cardiac calsequestrin (Casq2) associates with the Ryanodine Receptor 2 channel in the junctional sarcoplasmic reticulum to regulate Ca2+ release into the cytoplasm. Patients carrying mutations in CASQ2 display low resting heart rates under basal conditions and stress-induced polymorphic ventricular tachycardia (CPVT). In this study we generate and characterize novel conditional deletion and conditional rescue mouse models to test the influence of developmental programs on the heart rate and CPVT phenotypes...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29444191/restoration-of-services-in-disrupted-infrastructure-systems-a-network-science-approach
#6
Aybike Ulusan, Ozlem Ergun
Due to the ubiquitous nature of disruptive extreme events, functionality of the critical infrastructure systems (CIS) is constantly at risk. In case of a disruption, in order to minimize the negative impact to the society, service networks operating on the CIS should be restored as quickly as possible. In this paper, we introduce a novel network science inspired measure to quantify the criticality of components within a disrupted service network and develop a restoration heuristic (Cent-Restore) that prioritizes restoration efforts based on this measure...
2018: PloS One
https://www.readbyqxmd.com/read/29432651/a-20-year-historical-prospective-cohort-study-of-root-canal-treatments-a-multilevel-analysis
#7
C Prati, C Pirani, F Zamparini, M R Gatto, M G Gandolfi
AIM: To evaluate the number of healthy and functional root filled teeth of patients included in a recall program for at least 20 years. METHODOLOGY: Teeth were root filled by a single specialist following manual canal instrumentation, lateral/vertical compaction of gutta-percha and restored with glass-ionomer cements and bonding system/composite resin. In a large percentage of teeth a metal-ceramic crown was positioned during follow-up. Patients included in the recall program (n=130) were blindly assessed both clinically and radiographically (every 2 years) to evaluate clinical symptoms and periapical status (PAI)...
February 12, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29431744/a-histone-deacetylase-3-dependent-pathway-delimits-peripheral-myelin-growth-and-functional-regeneration
#8
Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski, Q Richard Lu
Deficits in Schwann cell-mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain elusive. Here, through small-molecule screening focusing on epigenetic modulators, we identified histone deacetylase 3 (HDAC3; a histone-modifying enzyme) as a potent inhibitor of peripheral myelinogenesis. Inhibition of HDAC3 enhanced myelin growth and regeneration and improved functional recovery after peripheral nerve injury in mice...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29430642/should-structured-exercise-be-promoted-as-a-model-of-care-dissemination-of-the-department-of-veterans-affairs-gerofit-program
#9
Miriam C Morey, Cathy C Lee, Steven Castle, Willy M Valencia, Leslie Katzel, Jamie Giffuni, Teresa Kopp, Heather Cammarata, Michelle McDonald, Kris A Oursler, Timothy Wamsley, Chani Jain, Janet P Bettger, Megan Pearson, Kenneth M Manning, Orna Intrator, Peter Veazie, Richard Sloane, Jiejin Li, Daniel C Parker
Exercise provides a wide range of health-promoting benefits, but support is limited for clinical programs that use exercise as a means of health promotion. This stands in contrast to restorative or rehabilitative exercise, which is considered an essential medical service. We propose that there is a place for ongoing, structured wellness and health promotion programs, with exercise as the primary therapeutic focus. Such programs have long-lasting health benefits, are easily implementable, and are associated with high levels of participant satisfaction...
February 12, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29428307/oocyte-vitrification-versus-ovarian-cortex-transplantation-in-fertility-preservation-for-adult-women-undergoing-gonadotoxic-treatments-a-prospective-cohort-study
#10
Cesar Diaz-Garcia, Javier Domingo, Juan Antonio Garcia-Velasco, Sonia Herraiz, Vicente Mirabet, Ignacio Iniesta, Ana Cobo, José Remohí, Antonio Pellicer
OBJECTIVE: To compare the efficacy of oocyte vitrification (OV) with that of ovarian cortex cryopreservation and transplantation (OCT) in women undergoing gonadotoxic treatments. DESIGN: Prospective observational cohort study. SETTING: Not applicable. PATIENT(S): Candidates for chemo-/radiotherapy who joined our fertility preservation (FP) program were included in this study between 2005 and 2015. One cohort included 1,024 patients undergoing OV; the other cohort included 800 patients undergoing OCT...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29416738/parp-1-inhibitors-sensitize-hnscc-cells-to-apr-246-by-inactivation-of-thioredoxin-reductase-1-trxr1-and-promotion-of-ros-accumulation
#11
Zhi-Xian Yin, Wei Hang, Gang Liu, Yi-Shu Wang, Xiang-Feng Shen, Qian-Hui Sun, Dong-Dong Li, Yong-Ping Jian, Yang-He Zhang, Cheng-Shi Quan, Qinghua Zeng, Yu-Lin Li, Rui-Xun Zhao, Qiang Ding, Zhi-Xiang Xu
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high for HNSCC patients with mutations in the TP53 gene although patients are responsive to surgery, irradiation, and chemotherapy early in the treatment. p53-Reactivation and Induction of Massive Apoptosis-1 (PRIMA-1) and its methylated analogue PRIMA-1 Met (also known as APR-246) are quinuclidine compounds that rescue the DNA-binding activity of mutant p53 (mut-p53) and restore the potential of wild-type p53...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414259/cd8-t-cell-exhaustion-in-chronic-infection-and-cancer-opportunities-for-interventions
#12
Masao Hashimoto, Alice O Kamphorst, Se Jin Im, Haydn T Kissick, Rathi N Pillai, Suresh S Ramalingam, Koichi Araki, Rafi Ahmed
Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but persistent antigen stimulation results in T cell exhaustion. Exhausted CD8 T cells have decreased effector function and proliferative capacity, partly caused by overexpression of inhibitory receptors such as programmed cell death (PD)-1. Blockade of the PD-1 pathway has opened a new therapeutic avenue for reinvigorating T cell responses, with positive outcomes especially for patients with cancer. Other strategies to restore function in exhausted CD8 T cells are currently under evaluation-many in combination with PD-1-targeted therapy...
January 29, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/29414066/strategies-to-overcome-hbv-specific-t-cell-exhaustion-checkpoint-inhibitors-and-metabolic-re-programming
#13
REVIEW
Paola Fisicaro, Carolina Boni, Valeria Barili, Diletta Laccabue, Carlo Ferrari
HBV-specific T cells play a key role in antiviral protection and failure to control HBV is associated with severely dysfunctional T cell responses. Therefore, functional T cell reconstitution represents a potential way to treat chronically infected patients. The growing understanding of the dysregulated transcriptional/epigenetic and metabolic programs underlying T cell exhaustion allows to envisage functional T cell reconstitution strategies based on the combined/sequential use of compounds able to induce decline of antigen load, checkpoint modulation, metabolic and epigenetic reprogramming with possible boosting of functionally restored responses by specific vaccines...
January 29, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29407859/an-index-to-quantify-deviations-from-normal-trunk-mobility-clinical-correlation-and-initial-test-of-validity
#14
Yannick Delpierre, Michel Ritz, Cyril Garnier
BACKGROUND: In case of people suffering from chronic low back pain, specific movements of the hip, pelvis, and trunk are associated with pain. Comparing range of motion measurements for multiple planes and from different segments and lines in reference to those of healthy individuals seems interesting but present interpretations challenge in relation to important number of variables and correlation with clinical data. METHODS: The proposed index is based on using principal component analysis to quantify differences in trunk mobility between patients with chronic low back pain and a control group...
January 24, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29404406/an-mll4-compass-lsd1-epigenetic-axis-governs-enhancer-function-and-pluripotency-transition-in-embryonic-stem-cells
#15
Kaixiang Cao, Clayton K Collings, Marc A Morgan, Stacy A Marshall, Emily J Rendleman, Patrick A Ozark, Edwin R Smith, Ali Shilatifard
Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the regulation of chromatin state contribute to both developmental disorders and disease state. Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins ASsociated with Set1) protein family that implements histone H3 lysine 4 monomethylation (H3K4me1) at enhancers, is essential for embryonic development and functions as a pancancer tumor suppressor. We define the roles of Mll4/COMPASS and its catalytic activity in the maintenance and exit of ground-state pluripotency in murine embryonic stem cells (ESCs)...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29398897/perceptions-of-severe-storms-climate-change-ecological-structures-and-resiliency-three-years-post-hurricane-sandy-in-new-jersey
#16
Joanna Burger, Michael Gochfeld
Global warming is leading to increased frequency and severity of storms that are associated with flooding, increasing the risk to urban, coastal populations. This study examined perceptions of the relationship between severe storms, sea level rise, climate change and ecological barriers by a vulnerable environmental justice population in New Jersey. Patients using New Jersey's Federally Qualified Health Centers were interviewed after Hurricane [Superstorm] Sandy because it is essential to understand the perceptions of uninsured, underinsured, and economically challenged people to better develop a resiliency strategy for the most vulnerable people...
December 2017: Urban Ecosystems
https://www.readbyqxmd.com/read/29390267/rehabilitation-program-based-on-sensorimotor-recovery-improves-the-static-and-dynamic-balance-and-modifies-the-basal-ganglia-neurochemistry-a-pilot-1h-mrs-study-on-parkinson-s-disease-patients
#17
Stefano Delli Pizzi, Rosa Grazia Bellomo, Simona Maria Carmignano, Emilio Ancona, Raffaella Franciotti, Marco Supplizi, Giovanni Barassi, Marco Onofrj, Laura Bonanni, Raoul Saggini
Rehabilitation interventions represent an alternative strategy to pharmacological treatment in order to slow or reverse some functional aspects of disability in Parkinson's disease (PD). To date, the neurophysiological mechanisms underlying rehabilitation-mediated improvement in PD patients are still poorly understood. Interestingly, growing evidence has highlighted a key role of the glutamate in neurogenesis and brain plasticity. The brain levels of glutamate, and of its precursor glutamine, can be detected in vivo and noninvasively as "Glx" by means of proton magnetic resonance spectroscopy (H-MRS)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377337/landscape-consequences-of-aggregation-rules-for-functional-equivalence-in-compensatory-mitigation-programs
#18
Francesco Accatino, Irena F Creed, Marian Weber
Mitigation and offset programs designed to compensate for ecosystem function losses due to development must balance losses from affected ecosystems and gains in restored ecosystems. Aggregation rules applied to ecosystem functions to assess site equivalence are based on implicit assumptions about the substitutability of functions among sites and can profoundly influence the distribution of restored ecosystem functions on the landscape. We investigated the consequences of rules applied to aggregation of ecosystem functions for wetland offsets in the Beaverhill watershed in Alberta, Canada...
January 26, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29352232/the-silent-healer-mir-205-5p-up-regulation-inhibits-epithelial-to-mesenchymal-transition-in-colon-cancer-cells-by-indirectly-up-regulating-e-cadherin-expression
#19
Diana Gulei, Lorand Magdo, Ancuta Jurj, Lajos Raduly, Roxana Cojocneanu-Petric, Alin Moldovan, Cristian Moldovan, Adrian Florea, Sergiu Pasca, Laura-Ancuta Pop, Vlad Moisoiu, Liviuta Budisan, Cecilia Pop-Bica, Cristina Ciocan, Rares Buiga, Mihai-Stefan Muresan, Rares Stiufiuc, Calin Ionescu, Ioana Berindan-Neagoe
EMT represents the dominant program within advanced stages of colon cancer, where cells acquire migratory characteristics in order to invade secondary tissues and form metastasis. Where the majority of the therapeutic strategies are concentrated on the reduction of the tumor mass through different apoptotic mechanisms, the present study advocates an important role for miR-205-5p in impairment of colon cancer cells migration and restoration of the epithelial phenotype. Upon identification of a homogenous downregulated profile for miR-205-5p in colon adenocarcinoma patients, functional studies demonstrated that experimental upregulation of this sequence is able to significantly raise the levels of E-cadherin through direct inhibition of ZEB1...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29333801/efficacy-of-the-regent-suit-based-rehabilitation-on-gait-emg-patterns-in-hemiparetic-subjects-a-pilot-study
#20
Luigi Iuppariello, Giovanni D'Addio, Maria Romano, Paolo Bifulco, Nicola Pappone, Bernardo Lanzillo, Mario Cesarelli
BACKGROUND: The recovery of the functional limb mobility of patients with cerebral damages can take great benefit of the role offered by proprioceptive rehabilitation. Recently have been developed a special Regent Suit (RS) for rehabilitative applications. Actually, there are preliminary studies which describes the effects of RS on gait recovery of stroke patients in acute stage, but none in chronic stage. Moreover, it is known that motor recovery does not always reflect improvements of the muscle activity and coactivity...
January 11, 2018: European Journal of Physical and Rehabilitation Medicine
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