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https://www.readbyqxmd.com/read/28078614/resistance-exercise-reduces-seizure-occurrence-attenuates-memory-deficits-and-restores-bdnf-signaling-in-rats-with-chronic-epilepsy
#1
Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Glauber Menezes Lopim, Diego Vannucci Campos, Jansen Fernandes, Francisco Romero Cabral, Ricardo Mario Arida
Epilepsy is a disease characterized by recurrent, unprovoked seizures. Cognitive impairment is an important comorbidity of chronic epilepsy. Human and animal model studies of epilepsy have shown that aerobic exercise induces beneficial structural and functional changes and reduces the number of seizures. However, little is yet understood about the effects of resistance exercise on epilepsy. We evaluated the effects of a resistance exercise program on the number of seizures, long-term memory and expression/activation of signaling proteins in rats with epilepsy...
January 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28075442/increased-expression-of-pd%C3%A2-l1-by-the-human-papillomavirus-16-e7-oncoprotein-inhibits-anticancer-immunity
#2
Chaoqi Liu, Jiao Lu, Huiqun Tian, Wei Du, Lin Zhao, Jing Feng, Ding Yuan, Zhiying Li
Cytotoxic T lymphocyte dysfunction is frequently associated with PD‑L1/PD‑1 pathway activation, and is a principal obstacle in cancer therapy. In the present study, the mechanisms underlying the human papillomavirus (HPV)‑induced evasion of cervical cancer cells to the host immune system via the programmed death ligand  1/programmed death 1 (PD‑L1/PD‑1) signaling pathway was investigated. A significant increase in the expression of the HPV16E7 viral protein and PD‑L1 in cervical tissues was observed when compared with normal cervical tissues...
January 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28067610/the-efficacy-of-a-computer-assisted-cognitive-rehabilitation-program-for-patients-with-mild-cognitive-deficits-a-pilot-study
#3
William E Mansbach, Ryan A Mace, Kristen M Clark
: Background/Study Context: Whereas computer-assisted cognitive rehabilitation (CR) programs show promise as tools for improving cognition in certain populations, there is not a consensus regarding their efficacy. This study focuses on restorative CR, a treatment designed to improve cognitive functioning affected by progressive brain changes due to disease or aging, through computer-assisted cognitive exercises. The purpose of this study was to investigate the efficacy of a computer-assisted restorative CR intervention for improving cognitive functioning in older rehabilitation patients with relatively mild cognitive deficits...
January 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28052564/regulation-of-the-mammalian-heat-shock-factor-1
#4
REVIEW
Sharadha Dayalan Naidu, Albena T Dinkova-Kostova
Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription factor heat shock factor 1 (HSF1) mediates the elevation of heat shock proteins, which are crucial components of the chaperone complex machinery and function to ameliorate protein misfolding and aggregation and restore protein homeostasis. In addition, HSF1 orchestrates a versatile transcriptional program that includes genes involved in repair and clearance of damaged macromolecules and maintenance of cell structure and metabolism, and provides protection against a broad range of cellular stress mediators, beyond heat shock...
January 4, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28049640/cml-patients-with-deep-molecular-responses-to-tki-have-restored-immune-effectors-decreased-pd-1-and-immune-suppressors
#5
Amy Hughes, Jade Clarson, Carine Tang, Ljiljana Vidovic, Deborah L White, Timothy P Hughes, Agnes S M Yong
Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment free remission (TFR). We investigated effector and suppressor immune responses in CML patients at diagnosis (n=21), on TKI (imatinib, nilotinib, dasatinib) prior to achieving major molecular response (pre-MMR, BCR-ABL1 >0.1%, n=8), MMR (BCR-ABL1 ≤0.1%, n=20), molecular response(4.5) (MR(4.5), BCR-ABL1 ≤0.0032%, n=16) and sustained TFR (BCR-ABL1 undetectable following cessation of TKI therapy, n=13)...
January 3, 2017: Blood
https://www.readbyqxmd.com/read/28048406/su-g-iep2-01-a-method-to-reduce-information-loss-in-jpeg-compressed-medical-images-using-richardson-lucy-deconvolution
#6
Y Choi, M Han, J Baek
PURPOSE: To minimize the information loss of medical images compressed by JPEG using Richardson-Lucy (RL) deconvolution. METHODS: We first generated reference images having three different noise structures; low-passed noise, high-passed noise, and white noise, which mimic noise structures for different medical imaging modalities. Each reference image was filtered by a Gaussian function and compressed/decompressed by JPEG 2000 algorithm. After decompression, RL deconvolution was applied to recover the reference image using the same Gaussian function...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039162/infiltration-of-cd8-t-cells-and-expression-of-pd-1-and-pd-l1-in-synovial-sarcoma
#7
Theodore S Nowicki, Ryan Akiyama, Rong Rong Huang, I Peter Shintaku, Xiaoyan Wang, Paul C Tumeh, Arun S Singh, Bartosz Chmielowski, Christopher T Denny, Noah Federman, Antoni Ribas
Tumors expressing programmed death ligand 1 (PD-L1) interact with the corresponding negative-signal generating immune receptor on the surface of CD8 T cells, PD-1, thereby suppressing antitumor activity. Therapeutics blocking this interaction have shown promise in various cancers by restoring functional antitumor T-cell activity. We explored the degree of PD-L1, PD-1, and CD8 expression in a retrospective analysis of 29 clinical synovial sarcoma samples. Quantitative immunohistochemistry and multiplex immunofluorescence were used to determine relative quantification of CD8(+) and PD-1(+) T cells and PD-L1 expression within the intratumor area and the interface between the tumor and the surrounding nontumor tissue (i...
December 30, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/28035385/increased-expression-of-pd-l1-by-the-human-papillomavirus-16-e7-oncoprotein-inhibits-anticancer-immunity
#8
Chaoqi Liu, Jiao Lu, Huiqun Tian, Wei Du, Lin Zhao, Jing Feng, Ding Yuan, Zhiying Li
Cytotoxic T lymphocyte dysfunction is frequently associated with PD‑L1/PD‑1 pathway activation, and is a principal obstacle in cancer therapy. In the present study, the mechanisms underlying the human papillomavirus (HPV)‑induced evasion of cervical cancer cells to the host immune system via the programmed death ligand  1/programmed death 1 (PD‑L1/PD‑1) signaling pathway was investigated. A significant increase in the expression of the HPV16E7 viral protein and PD‑L1 in cervical tissues was observed when compared with normal cervical tissues...
December 23, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28032062/impact-of-ego-resilience-and-family-function-on-quality-of-life-in-childhood-leukemia-survivors
#9
Ok-Hee Cho, Yang-Sook Yoo, Kyung-Hye Hwang
BACKGROUND: This study aimed to examine the impact of ego-resilience and family function on quality of life in childhood leukemia survivors. METHODS: This study targeted 100 pediatric leukemia survivors, who visited the Pediatric Hemato-Oncology Center in South Korea from Aug to Dec 2011. A structured questionnaire of ego-resilience, family function and quality of life used to collect data through direct interview with the pediatric patients and their parents. The correlation between the study variables analyzed using the Pearson's correlation coefficient, and the impact on quality of life analyzed using a stepwise multiple regression...
November 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28018900/redox-regulation-of-heart-regeneration-an-evolutionary-tradeoff
#10
Waleed M Elhelaly, Nicholas T Lam, Mohamed Hamza, Shuda Xia, Hesham A Sadek
Heart failure is a costly and deadly disease, affecting over 23 million patients worldwide, half of which die within 5 years of diagnosis. The pathophysiological basis of heart failure is the inability of the adult heart to regenerate lost or damaged myocardium. Although limited myocyte turnover does occur in the adult heart, it is insufficient for restoration of contractile function (Nadal-Ginard, 2001; Laflamme et al., 2002; Quaini et al., 2002; Hsieh et al., 2007; Bergmann et al., 2009, 2012). In contrast to lower vertebrates (Poss et al...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28003389/predictors-of-competency-to-stand-trial-in-connecticut-s-inpatient-juvenile-competency-restoration-program
#11
Joseph Chien, Kendell L Coker, Susan Parke, Nabyl Tejani, Remy A Sirken, Christina Sanchez-Jaquez, Fernando Rausch, Muhammad W Azeem
There are substantial differences between adults and juveniles in the context of competency restoration. Among juveniles, factors such as maturity level, age, intellectual functioning, and psychiatric diagnoses may affect competency to stand trial. In this study, subjects included all juveniles who were admitted to the Albert J. Solnit Children's Center for inpatient competency restoration in the period spanning January 1, 2005, through December 31, 2012. Sixty-one juveniles were referred during this period, and 58 were included in the final analyses...
December 2016: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/28003206/a-moderate-increase-in-dietary-zinc-reduces-dna-strand-breaks-in-leukocytes-and-alters-plasma-proteins-without-changing-plasma-zinc-concentrations
#12
Sarah J Zyba, Swapna V Shenvi, David W Killilea, Tai C Holland, Elijah Kim, Adrian Moy, Barbara Sutherland, Virginia Gildengorin, Mark K Shigenaga, Janet C King
BACKGROUND: Food fortification has been recommended to improve a population's micronutrient status. Biofortification techniques modestly elevate the zinc content of cereals, but few studies have reported a positive impact on functional indicators of zinc status. OBJECTIVE: We determined the impact of a modest increase in dietary zinc that was similar to that provided by biofortification programs on whole-body and cellular indicators of zinc status. DESIGN: Eighteen men participated in a 6-wk controlled consumption study of a low-zinc, rice-based diet...
December 21, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27994150/gfi1-foxo1-axis-controls-the-fidelity-of-effector-gene-expression-and-developmental-maturation-of-thymocytes
#13
Lewis Zhichang Shi, Jordy Saravia, Hu Zeng, Nishan S Kalupahana, Clifford S Guy, Geoffrey Neale, Hongbo Chi
Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into single-positive (SP) mature cells. Concomitant with these well-characterized events is the acquisition of a mature T-cell gene expression program characterized by the induction of the effector molecules IL-7Rα, S1P1, and CCR7, but the underlying mechanism remains elusive. We report here that transcription repressor Growth factor independent 1 (Gfi1) orchestrates the fidelity of the DP gene expression program and developmental maturation into SP cells...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27992468/genetic-diversity-and-population-structure-of-whitebark-pine-pinus-albicaulis-engelm-in-western-north-america
#14
Jun-Jun Liu, Richard Sniezko, Michael Murray, Ning Wang, Hao Chen, Arezoo Zamany, Rona N Sturrock, Douglas Savin, Angelia Kegley
Whitebark pine (WBP, Pinus albicaulis Engelm.) is an endangered conifer species due to heavy mortality from white pine blister rust (WPBR, caused by Cronartium ribicola) and mountain pine beetle (Dendroctonus ponderosae). Information about genetic diversity and population structure is of fundamental importance for its conservation and restoration. However, current knowledge on the genetic constitution and genomic variation is still limited for WBP. In this study, an integrated genomics approach was applied to characterize seed collections from WBP breeding programs in western North America...
2016: PloS One
https://www.readbyqxmd.com/read/27992239/differential-effects-of-two-rehabilitation-programs-following-anterior-cruciate-ligament-reconstruction
#15
Igor Setuain, Mikel Izquierdo, Fernando Idoate, Eder Bikandi, Esteban M Gorostiaga, Per Aagaard, Eduardo L Cadore, Jesús Alfaro-Adrián
Context- The muscular function restoration related to the type of physical rehabilitation followed after anterior cruciate ligament reconstruction (ACLR) using autologous hamstring tendon graft in terms of strength and cross sectional area (CSA) remain controversial. Objective- To analyze the CSA and force output of quadriceps and hamstring muscles in subjects following either an Objective Criteria-Based rehabilitation (OCBR) algorithm or the usual care (UCR) for ACL rehabilitation in Spain, before and one year after undergoing an ACLR...
December 19, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27974689/pd-1-and-its-ligands-are-important-immune-checkpoints-in-cancer
#16
REVIEW
Yinan Dong, Qian Sun, Xinwei Zhang
Checkpoint programmed death-1 (PD-1)/programmed cell death ligands (PD-Ls) have been identified as negative immunoregulatory molecules that promote immune evasion of tumor cells. The interaction of PD-1 and PD-Ls inhibits the function of T cells and tumor-infiltrating lymphocytes (TIL) while increasing the function of immunosuppressive regulatory T cells (Tregs). This condition causes the tumor cells to evade immune response. Thus, the blockade of PD-1/PD-L1 enhances anti-tumor immunity by reducing the number and/or the suppressive activity of Tregs and by restoring the activity of effector T cells...
December 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27968838/effect-of-ocular-reconstruction-on-brain-function-and-structure-in-people-with-age-related-cataracts-a-prospective-controlled-clinical-trial
#17
Haotian Lin, Li Zhang, Kevin Chan, Yingwei Qiu, Duoru Lin, Wan Chen, Hui Chen, Yizhi Liu, Weirong Chen
BACKGROUND: Healthy ageing is accompanied by simultaneous decline of visual and neural function. Studies in animals and humans provide converging evidence that these functions' decrease is mostly associated with structural change in ocular and brain structure. We investigated whether regaining visual function after ocular reconstruction was associated with functional and structural changes in the brain. METHODS: We did a prospective controlled clinical trial including 21 consecutive typical ageing patients (42 eyes; mean age 63·14 years, SD 7·82) with decreased visual function and diagnosis of bilateral age-related cataracts requiring phacoemulsification surgery and multifocal or monofocal intraocular lens implantation...
October 2016: Lancet
https://www.readbyqxmd.com/read/27932512/atf6-decreases-myocardial-ischemia-reperfusion-damage-and-links-er-stress-and-oxidative-stress-signaling-pathways-in-the-heart
#18
Jung-Kang Jin, Erik A Blackwood, Khalid M Azizi, Donna J Thuerauf, Asal G Fahem, Christoph Hofmann, Randal J Kaufman, Shirin Doroudgar, Christopher C Glembotski
RATIONALE: ER stress causes accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6, which induces ER stress response genes. Myocardial ischemia induces the ER stress response; however, neither the function of this response nor whether it is mediated by ATF6 is known. OBJECTIVE: Here, we examined the effects of blocking the ATF6-mediated ER stress response on ischemia/reperfusion (I/R) in cardiac myocytes and mouse hearts. METHODS AND RESULTS: Knockdown of ATF6 in cardiac myocytes subjected to I/R increased ROS and necrotic cell death, which were mitigated by ATF6 overexpression...
December 8, 2016: Circulation Research
https://www.readbyqxmd.com/read/27920788/vegetative-and-adaptive-traits-predict-different-outcomes-for-restoration-using-hybrids
#19
Philip A Crystal, Nathanael I Lichti, Keith E Woeste, Douglass F Jacobs
Hybridization has been implicated as a driver of speciation, extinction, and invasiveness, but can also provide resistant breeding stock following epidemics. However, evaluating the appropriateness of hybrids for use in restoration programs is difficult. Past the F1 generation, the proportion of a progenitor's genome can vary widely, as can the combinations of parental genomes. Detailed genetic analysis can reveal this information, but cannot expose phenotypic alterations due to heterosis, transgressive traits, or changes in metabolism or development...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27916176/functional-assessment-and-transplantation-of-the-donor-heart-after-circulatory-death
#20
Simon J Messer, Richard G Axell, Simon Colah, Paul A White, Marian Ryan, Aravinda A Page, Barbora Parizkova, Kamen Valchanov, Christopher W White, Darren H Freed, Euan Ashley, John Dunning, Martin Goddard, Jayan Parameshwar, Christopher J Watson, Thomas Krieg, Ayyaz Ali, Steven Tsui, Stephen R Large
BACKGROUND: After a severe shortage of brain-dead donors, the demand for heart transplantation has never been greater. In an attempt to increase organ supply, abdominal and lung transplant programs have turned to the donation after circulatory-determined death (DCD) donor. However, because heart function cannot be assessed after circulatory death, DCD heart transplantation was deemed high risk and never adopted routinely. We report a novel method of functional assessment of the DCD heart resulting in a successful clinical program...
December 2016: Journal of Heart and Lung Transplantation
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