keyword
MENU ▼
Read by QxMD icon Read
search

Activation

keyword
https://www.readbyqxmd.com/read/28749619/healthy-plant-foods-intake-could-protect-against-prostate-cancer-risk-a-case-control-study
#1
Yahya Jalilpiran, Erfan Hezaveh, Salmeh Bahmanpour, Shiva Faghih
Background: Several studies have investigated the association between healthy plant foods intake and prostate cancer risk with inconsistent results. So this study was conducted to examine the existence of any possible association between healthy plant foods and prostate cancer risk. Materials and Methods: Sixty newly diagnosed prostate cancer cases and 60 controls engaged in a hospital-based case-control study. A validated 16o-items semi-quantitative FFQ was used to assess usual dietary intakes. Energy-adjusted amounts of healthy plant foods intake were calculated using the residual method...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749617/depression-hopelessness-and-social-support-among-breast-cancer-patients-in-highly-endogamous-population
#2
Abdulbari Bener, Reem Alsulaiman, Lisa Doodson, Tony Agathangelou
Aim: The aim of this study was to assess the relationship between different demographic variables, hopelessness, depression and social support of Breast cancer patients in Qatari’s population. Design: This is an observational cohort hospital based study. Subjects and Methods: The study included 678 breast cancer patients. The questionnaires included a demographic questionnaire, the Beck Hopelessness Scale (BHS), Back Depression Scale (BDS) and Multidimensional Scale of Perceived Social Support (MSPSS). The demographic questionnaire was used to assess patients’ basic information including gender, age, marital status, education, family size, and place of residence...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749602/clinical-pattern-and-prevalence-of-upper-gastrointestinal-toxicity-in-ketamine-abusers
#3
Shirley Yuk Wah Liu, Stephen Ka Kei Ng, Yuk Him Tam, Samuel Chi Hang Yee, Franco Pui Tak Lai, Cindy Yuek Lam Hong, Philip Wai Yan Chiu, Enders Kwok Wai Ng, Chi Fai Ng
AIM: While evidence about ketamine-related urological and hepatobiliary injuries was emerging, evaluation about upper gastrointestinal toxicity from ketamine abuse was uncommon. This study aims to investigate the clinical pattern and prevalence of upper gastrointestinal symptoms in inhalational ketamine abusers. METHODS: This was a cross sectional study of 611 consecutive ketamine abusers who were seeking treatment for ketamine uropathy in a tertiary hospital setting between August 2008 and June 2016...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#4
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749594/seizure-activity-per-se-does-not-induce-tissue-damage-markers-in-human-neocortical-focal-epilepsy
#5
Laura Rossini, Rita Garbelli, Vadym Gnatkovsky, Giuseppe Didato, Flavio Villani, Roberto Spreafico, Francesco Deleo, Giorgio Lo Russo, Giovanni Tringali, Francesca Gozzo, Laura Tassi, Marco de Curtis
Objective The contribute of recurring seizures to the progression of epileptogenesis is debated. Seizure-induced brain damage is not conclusively demonstrated both in humans and in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on post-surgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant focal epilepsy. Methods The expression patterns of specific glial, neuronal and inflammatory molecules was evaluated by immunohistochemistry in the core of type II focal cortical dysplasias (FCD-II), at the FCD boundary (perilesion) and in the adjacent normal-appearing area included in the epileptogenic region...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749590/the-marulu-strategy-2008-2012-overcoming-fetal-alcohol-spectrum-disorder-fasd-in-the-fitzroy-valley
#6
James P Fitzpatrick, June Oscar, Maureen Carter, Elizabeth J Elliott, Jane Latimer, Edie Wright, John Boulton
OBJECTIVE: Aboriginal leaders concerned about high rates of Fetal Alcohol Spectrum Disorder (FASD) in the Fitzroy Valley, remote north-western Australia, introduced restrictions on access to take-away full-strength alcohol. Following this, Aboriginal leaders engaged strategic partners in a broader strategy to address FASD in the region. The aim of this study was to develop and implement a community-led, researcher-supported, FASD strategy. METHODS: A review of literature focusing on community-led FASD strategies identified key components that informed the Marulu FASD strategy...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749583/chiral-sulfur-functional-groups-as-definers-of-the-chirality-at-the-metal-in-ir-and-rh-half-sandwich-complexes-a-combined-cd-x-ray-study
#7
Miguel A Sierra, Maria C de la Torre, Roberto Fernandez de la Pradilla, Alma Viso, Maria Frutos, Marta G Avello, Marina Velado, Heinz Gornitzka, Catherine Hemmert
Mesoionic carbenes (MIC) derived from triazolium salts containing chiral sulfoxide or sulfoximine functional groups lead to enantiopure chiral-at-metal Ir(III) and Rh(III) half-sandwich complexes, through the sequence MIC complexation-C-H aromatic activation. The process is efficient and totally diastereoselective in the formation of enantiopure five membered metallacycles. The use of the enantiomers of the sulfur chiral groups allows to prepare complexes having opposite configurations at the metal. Complete retention of the configuration at the metal center is observed during the formation of cationic Ir(III) complexes and upon insertion of alkynes into the Ir(III)-C bond, as demonstrated by a combined Circular Dichroism (CD)-X-ray study...
July 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28749581/prediction-of-transporter-mediated-drug-drug-interactions-for-baricitinib
#8
Maria M Posada, Ellen A Cannady, Christopher D Payne, Xin Zhang, James A Bacon, Y Anne Pak, J William Higgins, Nazila Shahri, Stephen D Hall, Kathleen M Hillgren
Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic and renal uptake and efflux drug transporters, based on the ratio of the unbound maximum eliminating-organ inlet concentration and the in vitro half-maximal inhibitory concentrations (IC50 ). In vitro, baricitinib was a substrate for organic anion transporter (OAT)3, multidrug and toxin extrusion protein (MATE)2-K, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP)...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28749573/il-6-stat3-signaling-as-a-promising-target-to-improve-the-efficacy-of-cancer-immunotherapy
#9
REVIEW
Hidemitsu Kitamura, Yosuke Ohno, Yujiro Toyoshima, Junya Ohtake, Shigenori Homma, Hideki Kawamura, Norihiko Takahashi, Akinobu Taketomi
Overcoming the immunosuppressive state in tumor microenvironments is a critical issue to improve the efficacy of cancer immunotherapy. Interleukin (IL)-6, a pleiotropic cytokine, is highly produced in the tumor-bearing host. Previous studies have indicated that IL-6 suppresses the antigen presentation ability of dendritic cells (DCs) through activation of signal transducer and activator of transcription 3 (STAT3). Thus, we focused on the precise effect of the IL-6/STAT3 signaling cascade on human DCs and the subsequent induction of antitumor T cell immune responses...
July 27, 2017: Cancer Science
https://www.readbyqxmd.com/read/28749567/ab-initio-energetics-of-si%C3%AF-o-bond-cleavage
#10
Carolin Hühn, Andreas Erlebach, Dorothea Mey, Lothar Wondraczek, Marek Sierka
A multilevel approach that combines high-level ab initio quantum chemical methods applied to a molecular model of a single, strain-free SiOSi bridge has been used to derive accurate energetics for SiO bond cleavage. The calculated SiO bond dissociation energy and the activation energy for water-assisted SiO bond cleavage of 624 and 163 kJ mol(-1) , respectively, are in excellent agreement with values derived recently from experimental data. In addition, the activation energy for H2 O-assisted SiO bond cleavage is found virtually independent of the amount of water molecules in the vicinity of the reaction site...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749566/the-facilitators-and-barriers-of-physical-activity-among-aboriginal-and-torres-strait-islander-regional-sport-participants
#11
Claudie Péloquin, Thomas Doering, Stephanie Alley, Amanda Rebar
BACKGROUND: Disparities in health perspectives between Indigenous and non-Indigenous populations are major concerns in many of the world's well-developed nations. Indigenous populations are largely less healthy, more prone to chronic diseases, and have an earlier overall mortality than non-Indigenous populations. Low levels of physical activity (PA) contribute to the high levels of disease in Indigenous Australians. METHOD: Qualitative analysis of structured one-on-one interviews discussing PA in a regional setting...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749565/melatonin-suppresses-platelet-activation-and-function-against-cardiac-ischemia-reperfusion-injury-via-ppar%C3%AE-fundc1-mitophagy-pathways
#12
Hao Zhou, Dandan Li, Pingjun Zhu, Shunying Hu, Nan Hu, Sai Ma, Ying Zhang, Tianwen Han, Jun Ren, Feng Cao, Yundai Chen
Platelet activation is a major (patho-) physiological mechanism that underlies ischemia/reperfusion (I/R) injury. In this study, we explored the molecular signals for platelet hyperactivity and investigated the beneficial effects of melatonin on platelet reactivity in response to I/R injury. After reperfusion, peroxisome proliferator-activated receptor γ (PPARγ) was progressively downregulated in patients with acute myocardial infarction undergoing coronary artery bypass grafting (CABG) surgery and in mice with I/R injury model...
July 27, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28749562/school-based-systems-change-for-obesity-prevention-in-adolescents-outcomes-of-the-australian-capital-territory-it-s-your-move
#13
Mary Malakellis, Erin Hoare, Andrew Sanigorski, Nicholas Crooks, Steven Allender, Melanie Nichols, Boyd Swinburn, Cal Chikwendu, Paul M Kelly, Solveig Petersen, Lynne Millar
OBJECTIVE: The Australian Capital Territory 'It's Your Move!' (ACT-IYM) was a three-year (2012-2014) systems intervention to prevent obesity among adolescents. METHODS: The ACT-IYM project involved three intervention schools and three comparison schools and targeted secondary students aged 12-16 years. The intervention consisted of multiple initiatives at individual, community, and school policy level to support healthier nutrition and physical activity. Intervention school-specific objectives related to increasing active transport, increasing time spent physically active at school, and supporting mental wellbeing...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749561/trends-in-prevalence-of-leisure-time-physical-activity-and-inactivity-results-from-australian-national-health-surveys-1989-to-2011
#14
Josephine Chau, Tien Chey, Sarah Burks-Young, Lina Engelen, Adrian Bauman
OBJECTIVE: To examine trends in leisure time physical activity and inactivity in Australians aged 15 years or older from 1989 to 2011. METHOD: We used data from six Australian National Health Surveys conducted from 1989/90 to 2011/12 in which physical activity was assessed using comparable questions. Analyses examined trends in the prevalence of sufficient physical activity (≥150 minutes/week moderate-to-vigorous physical activity) and of inactivity (<30 minutes/week moderate-to-vigorous physical activity)...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749559/recombinant-cccdna-of-hepatitis-b-virus-induces-long-term-viral-persistence-with-chronic-hepatitis-in-a-mouse-model
#15
Gaiyun Li, Yuanfei Zhu, Dianhui Shao, Hao Chang, Xiaoming Zhang, Dongming Zhou, Yueqiu Gao, Ke Lan, Qiang Deng
Covalently closed circular (ccc) DNA of hepatitis B virus (HBV) is critical for viral persistence in vivo. We recently reported a technique involving recombinant (r) cccDNA of HBV by site-specific DNA recombination. Using hydrodynamic injection, rcccDNA induces a temporarily prolonged HBV anigenemia in immunocompetent mice, similar to acute resolving HBV infection. In this study, we simulated the pathophysiological impact of chronic hepatitis by which to reproduce (r)cccDNA persistence in mouse models. We showed that rcccDNA achieved long-lasting persistence in the presence of a compromised immune response or when transcriptional activity was repressed...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749554/high-energy-resolution-x-ray-absorption-spectroscopy-for-identification-of-reactive-surface-species-on-supported-single-site-iridium-catalysts
#16
Adam S Hoffman, Dimosthenis Sokaras, Shengjie Zhang, Louise M Debefve, Chia-Yu Fang, Alessandro Gallo, Thomas Kroll, David A Dixon, Simon R Bare, Bruce C Gates
We report high-energy-resolution X-ray absorption spectroscopy detection of ethylene and CO ligands adsorbed on catalytically active iridium centers isolated on zeolite HY and on MgO supports. The data are supported by density functional theory and FEFF X-ray absorption near-edge modelling, together with infrared (IR) spectra. The results demonstrate that high-energy-resolution X-ray absorption spectra near the iridium LIII (2p3/2 ) edge provide clearly ascribable, distinctive signatures of the ethylene and CO ligands and illustrate effects of supports and other ligands...
June 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28749535/inhibition-of-histone-deacetylases-sensitizes-egfr-tki-resistant-non-small-cell-lung-cancer-cells-to-erlotinib-in-vitro-and-in-vivo
#17
Weiwei Yu, Weiqiang Lu, Guoliang Chen, Feixiong Cheng, Hui Su, Yihua Chen, Mingyao Liu, Xiufeng Pang
BACKGROUND AND PURPOSE: Intrinsic and/or acquired resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) commonly occurs in patients with non-small-cell lung cancer (NSCLC). Here, we develop a combined therapy of histone deacetylase inhibition by a novel HDAC inhibitor, YF454A, with erlotinib to overcome EGFR-TKI resistance in NSCLC. EXPERIMENTAL APPROACH: The sensitization of erlotinib by YF454A was examined in a panel of EGFR-TKI-resistant NSCLC cell lines in vitro and two different erlotinib-resistant NSCLC xenograft mouse models in vivo...
July 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28749529/effect-and-acceptance-of-silver-diamine-fluoride-treatment-on-dental-caries-in-primary-teeth
#18
Jennifer Clemens, Jaana Gold, Jeffrey Chaffin
OBJECTIVES: Silver diamine fluoride (SDF) treatment has been identified as a potential solution to address the dental public health issues of untreated dental caries and insufficient access to care. The current study assessed the effectiveness of 38 percent SDF in arresting active dental caries lesions and in reducing or preventing associated dental pain and infections in young, at-risk children. METHODS: We enrolled 32 children aged 2-5 years with 118 active caries lesions in primary teeth from a community dental clinic in Oregon...
July 27, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28749522/palladium-catalyzed-decarboxylative-decarbonylative-and-dehydrogenative-c-sp-2-h-acylation-at-room-temperature
#19
Asik Hossian, Manash Kumar Manna, Kartic Manna, Ranjan Jana
Over the past few decades, an impressive array of C-H activation methodology has been developed for organic synthesis. However, due to the inherent inertness of the C-H bonds (e.g. ∼110 kcal mol(-1) for the cleavage of C(aryl)-H bonds) harsh reaction conditions have been realized to overcome high energetic transition states resulting in a limited substrate scope and functional group tolerance. Therefore, the development of mild C-H functionalization protocols is in high demand to exploit the full potential of the C-H activation strategy in the synthesis of a complex molecular framework...
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28749506/the-origin-of-high-electrocatalytic-activity-of-hydrogen-peroxide-reduction-reaction-by-a-g-c3n4-hopg-sensor
#20
C G Gomez, A M Silva, M C Strumia, L B Avalle, M I Rojas
Graphitic carbon nitride (g-C3N4) was synthesized from a low-cost precursor by means of a thermal process. The product was characterized by several spectroscopic techniques and the crystallinity was analyzed by X-ray diffraction. In the manufacture of the sensor, g-C3N4 was chemically exfoliated and a film was placed on the surface of a Highly Oriented Pyrolytic Graphite (HOPG). We compared the electrocatalytic activities of g-C3N4/HOPG and pristine HOPG surfaces as sensors for H2O2 quantification in buffer solution at pH 7...
July 27, 2017: Nanoscale
keyword
keyword
37398
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"