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https://www.readbyqxmd.com/read/27914369/dna-tetrahedral-scaffolds-based-platform-for-the-construction-of-electrochemiluminescence-biosensor
#1
Qiu-Mei Feng, Zhen Zhou, Mei-Xing Li, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
Proximal metallic nanoparticles (NPs) could quench the electrochemiluminescence (ECL) emission of semiconductor quantum dots (QDs) due to Förster energy transfer (FRET), but at a certain distance, the coupling of light-emission with surface plasmon resonance (SPR) result in enhanced ECL. Thus, the modification strategies and distances control between QDs and metallic NPs are critical for the ECL intensity of QDs. In this strategy, a SPR enhanced ECL sensor based on DNA tetrahedral scaffolds modified platform was reported for the detection of telomerase activity...
November 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27914366/rapid-and-low-cost-biosensor-for-the-detection-of-staphylococcus-aureus
#2
Ghadeer A R Y Suaifan, Sahar Alhogail, Mohammed Zourob
Staphylococcus aureus (S. aureus) is one of the most common etiological agents in hospital-acquired infections and food-borne illness. S. aureus toxins and virulence proteases often circulate in host blood vessels leading to life-threatening diseases. Standard identification approaches include bacterial culturing method, which takes several days. Other nucleic acid-based methods were expensive and required trained personnel. To surmount these limitations, a paper-based biosensor was developed. The sensing mechanism was based on the proteolytic activity of S...
November 21, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27914363/new-insights-into-the-sar-and-drug-combination-synergy-of-2-quinolin-4-yloxy-acetamides-against-mycobacterium-tuberculosis
#3
Bruno Couto Giacobbo, Kenia Pissinate, Valnês Rodrigues-Junior, Anne Drumond Villela, Estêvão Silveira Grams, Bruno Lopes Abbadi, Fernanda Teixeira Subtil, Nathalia Sperotto, Rogério Valim Trindade, Davi Fernando Back, Maria Martha Campos, Luiz Augusto Basso, Pablo Machado, Diógenes Santiago Santos
2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) values against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains in the submicromolar range. Furthermore, the most active compounds had no apparent toxicity to mammalian cells, and they showed intracellular activities similar to those of isoniazid and rifampin in a macrophage model of Mtb infection...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914362/an-overview-of-the-binding-models-of-fgfr-tyrosine-kinases-in-complex-with-small-molecule-inhibitors
#4
REVIEW
Weiyan Cheng, Mixiang Wang, Xin Tian, Xiaojian Zhang
The fibroblast growth factor receptor (FGFR) family receptor tyrosine kinase (RTK) includes four structurally related members, termed as FGFR1, FGFR2, FGFR3, and FGFR4. Given its intimate role in the progression of several solid tumors, excessive FGFR signaling provides an opportunity for anticancer therapy. Along with extensive pharmacological studies validating the therapeutic potential of targeting the FGFRs for cancer treatment, co-crystal structures of FGFRs/inhibitors are continuously coming up to study the mechanism of actions and explore new inhibitors...
November 25, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914361/development-of-cxcr4-modulators-by-virtual-hts-of-a-novel-amide-sulfamide-compound-library
#5
Renren Bai, Qi Shi, Zhongxing Liang, Younghyoun Yoon, Yiran Han, Amber Feng, Shuangping Liu, Yoonhyeun Oum, C Chris Yun, Hyunsuk Shim
CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for anti-inflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign...
November 24, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914354/3d-qsar-predictions-for-%C3%AE-cyclodextrin-binding-constants-using-quantum-mechanically-based-descriptors
#6
Lukas Linden, Kai-Uwe Goss, Satoshi Endo
Binding of organic chemicals to α-cyclodextrin (αCD) is a typical example for host-guest complexation that is influenced by the 3D-structure of both the binding site (host) and the solute (guest). Prediction of the binding constant is challenging and requires a successful representation of the binding site-solute interactions in the 3D-space. In this study, we tested if a 3D quantitative structure activity relationship (3D-QSAR) model with quantum mechanically based local sigma profiles (LSPs) derived from the COSMOsar3D method is capable of predicting αCD binding constants from the most recent literature and how the model performs in comparison to a standard comparative molecular field analysis and to a reference 2D-QSAR...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914350/phosphorus-flows-in-a-peri-urban-region-with-intensive-food-production-a-case-study
#7
S Bittman, S C Sheppard, D Poon, D E Hunt
Excess phosphorus (P) in peri-urban regions is an emerging issue, whereas there is global depletion of quality mined supplies of P. The flow of P across the landscape leading to regional surpluses and deficits is not well understood. We computed a regional P budget with internal P flows in a fairly discreet peri-urban region (Lower Fraser Valley, BC) with closely juxtaposed agricultural and non-agricultural urban ecosystems, in order to clarify the relationship between food production, food consumption and other activities involving use of P (e...
November 30, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27914342/cu3-btc-2-catalyzed-dehydrogenative-coupling-of-dimethylphenylsilane-with-phenol-and-homocoupling-of-dimethylphenylsilane-to-disiloxane
#8
Nagaraj Anbu, Amarajothi Dhakshinamoorthy
Cu3(BTC)2 (BTC: 1,3,5-benzenetricarboxylic acid) showed to be an efficient and reusable heterogeneous solid catalyst for the formation of SiO bond through dehydrogenative coupling of dimethylphenylsilane (1) with phenol under mild reaction conditions. It is observed that Fe(BTC), MIL-101(Cr) and UiO-66(Zr) are not able to promote this cross coupling between 1 and phenol. Cu3(BTC)2 exhibits higher stability and activity compared to other MOFs studied here. Furthermore, Cu3(BTC)2 is reused for three consecutive cycles with a slight decay in its activity...
November 24, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914341/single-crystalline-titanium-dioxide-hollow-tetragonal-nanocones-with-large-exposed-101-facets-for-excellent-photocatalysis
#9
Zhengcui Wu, Yejing Xue, Zexian Zou, Xia Wang, Feng Gao
Crystal facet engineering and surface modification of semiconductor have become important strategies to improve photocatalytic activity by optimizing surface charge carrier separation/transfer and extending solar spectrum utilization. In this work, we report anatase single-crystalline TiO2 hollow tetragonal nanocones with large exposed (101) facets by a facile liquid-phase interfacial synthetic strategy, using the hydrolysis of tetrabutyltitanate with adscititious water in the organic solvent of cyclohexane and a capping agent of 1, 6-hexanediamine...
November 23, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914335/studies-on-the-influence-of-%C3%AE-cyclodextrin-on-graphene-oxide-and-its-synergistic-activity-to-the-electrochemical-detection-of-nitrobenzene
#10
Murugan Velmurugan, Natarajan Karikalan, Shen-Ming Chen, Zi-Chi Dai
The impact of the β-cyclodextrin (β-CD) on the graphene oxide (GO) was considerably altered the activity of electrochemical sensors. Hence, the present study, we scrutinized the electrocatalytic determination of nitrobenzene (NB) by changing the different loading level of β-CD on GO modified electrodes. The composites were prepared by the simple ultrasonication method and characterized by UV-Visible spectroscopy, infrared spectroscopy and scanning electron microscope. Interestingly, the synergistic electrocatalytic activity was appeared for the 1...
November 10, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914334/preparation-of-janus-type-catalysts-and-their-catalytic-performance-at-emulsion-interface
#11
Yijiang Liu, Jiankang Hu, Xiaotian Yu, Xinyu Xu, Yong Gao, Huaming Li, Fuxin Liang
Two Janus-type catalysts were synthesized by selective modification and further functionalization with metal nanoparticles on one or both beads of snowman-like Janus particles. The catalytic performance of Janus-type catalysts both in homogeneous and interfacial reaction systems was systematically investigated using the reduction of nitro-compound as model reaction. The results showed that Janus-type catalysts have excellent catalytic activity in homogeneous reaction system and they are easy to recycle. Further, the Janus-type catalysts exhibited more efficient catalytic activity at emulsion interface than that of oil-water biphasic interface due to the exposed Au nanoparticles on snowman-like Janus particles offer high accessibility to reactants...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914332/amyloid-graphene-oxide-as-immobilization-platform-of-au-nanocatalysts-and-enzymes-for-improved-glucose-sensing-activity
#12
Xiaochen Wu, Mingjie Li, Zehui Li, Lili Lv, Yan Zhang, Chaoxu Li
Two-dimensional GO nanosheets and one-dimensional lysozyme nanofibrils were hybridized through electrostatic interaction to get a novel amyloid-GO composite, which promised a biocompatible immobilization platform for Au nanocatalysts as well as enzymes. The immobilization platform could load a large and tunable amount of Au NPs while maintaining their high catalytic activity. The immobilized catalysts showed high electrochemical behaviors, being ideal as glucose sensing systems. Furthermore, enzymes could also be immobilized on the residual bare surfaces of amyloid-GO, and served by a colorimetric method for a sensitive and selective analytical glucose-detecting platform...
November 16, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914330/synergistic-effect-of-p-n-heterojunction-supporting-and-zeolite-nanoparticles-in-enhanced-photocatalytic-activity-of-nio-and-sno2
#13
Hadis Derikvandi, Alireza Nezamzadeh-Ejhieh
Increased photocatalytic activity of NiO and SnO2 was achieved by coupling and supporting of them onto clinoptilolite nanoparticles (NC) via calcination of Ni(II)-Sn(IV) - exchanged NC in photocatalytic degradation of metronidazole (MZ) aqueous solution. XRD, XRF, FTIR, SEM, X-ray mapping, DRS, TEM, BET Cyclic voltammetry and electrochemical impedance spectroscopy techniques (EIS) were used for characterization of samples. Red shift occurred in bang gap energies of the coupled semiconductors with respect to monocomponent one...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914328/synthesis-and-stability-of-ir-820-and-fitc-doped-silica-nanoparticles
#14
Atul V Thorat, Tandra Ghoshal, Lan Chen, Justin D Holmes, Michael A Morris
Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914325/fabrication-of-metronidazole-loaded-poly-%C3%AE%C2%B5-caprolactone-zein-core-shell-nanofiber-membranes-via-coaxial-electrospinning-for-guided-tissue-regeneration
#15
Min He, Huiyi Jiang, Rui Wang, Yi Xie, Changsheng Zhao
To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix...
November 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914321/functional-regulation-of-ginsenoside-biosynthesis-by-rna-interferences-of-a-udp-glycosyltransferase-gene-in-panax-ginseng-and-panax-quinquefolius
#16
Chao Lu, Shoujing Zhao, Guanning Wei, Huijuan Zhao, Qingling Qu
Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng) have been used as medicinal and functional herbal remedies worldwide. Different properties of P. ginseng and P. quinquefolius were confirmed not only in clinical findings, but also at cellular and molecular levels. The major pharmacological ingredients of P. ginseng and P. quinquefolius are the triterpene saponins known as ginsenosides. The P. ginseng roots contain a higher ratio of ginsenoside Rg1:Rb1 than that in P. quinquefolius...
November 25, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27914318/older-adults-attentional-deployment-differential-gaze-patterns-for-different-negative-mood-states
#17
Ineke Demeyer, Alvaro Sanchez, Rudi De Raedt
BACKGROUND AND OBJECTIVES: Older adults are characterized by an attentional preference for positive over negative information. Since this positivity effect is considered to be an emotion regulation strategy, it should be more pronounced when emotion regulation is needed. In contrast to previous studies that focused on the effects of sad mood on attention, we used a stressor to activate emotion regulation and evaluate the effects of different types of mood state changes. Moreover, we evaluated mood effects on attentional processes using a paradigm that allows disentangling between different attentional engagement and disengagement processes...
November 24, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27914311/stepwatch-accuracy-during-walking-running-and-intermittent-activities
#18
Lindsay P Toth, David R Bassett, Scott E Crouter, Brittany S Overstreet, Samuel R LaMunion, Susan Park, Shahnawaz N Notta, Cary M Springer
INTRODUCTION: The purpose of this study was two-fold: 1) to investigate effects of cadence and sensitivity settings for the StepWatch (SW3) on step count accuracy over a wide range of ambulatory speeds, and 2) to compare the preprogrammed "quick start" settings to modified settings during intermittent lifestyle activities. METHODS: Part 1: Fifteen participants (18-57 years of age) performed two trials of treadmill walking and running at ten speeds ranging from 26...
November 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27914305/effectiveness-of-a-cross-circuit-exercise-training-program-in-improving-the-fitness-of-overweight-or-obese-adolescents-with-intellectual-disability-enrolled-in-special-education-schools
#19
Wen-Lan Wu, Yu-Fen Yang, I-Hua Chu, Hsiu-Tao Hsu, Feng-Hua Tsai, Jing-Min Liang
This study assessed the effects of a cross-circuit training intervention program on the body composition, cardiorespiratory fitness, balance, and muscular strength endurance of overweight or obese students with intellectual disability. A total of 43 students with intellectual disability (aged 13-19 years) were enrolled in this program; 28 overweight/obese students were assigned to either an obesity-control group (n=14) or obesity-exercise group (n=14), and those with normal weight were assigned to a normal weight group (n=15)...
November 30, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27914300/structure-based-analysis-of-bacilli-and-plasmid-dihydrofolate-reductase-evolution
#20
Mona Alotaibi, Ben Delos Reyes, Tin Le, Phuong Luong, Faramarz Valafar, Robert P Metzger, Gary B Fogel, David Hecht
Dihydrofolate reductase (DHFR), a key enzyme in tetrahydrofolate-mediated biosynthetic pathways, has a structural motif known to be highly conserved over a wide range of organisms. Given its critical role in purine and amino acid synthesis, DHFR is a well established therapeutic target for treating a wide range of prokaryotic and eukaryotic infections as well as certain types of cancer. Here we present a structural-based computer analysis of bacterial (Bacilli) and plasmid DHFR evolution. We generated a structure-based sequence alignment using 7 wild-type DHFR x-ray crystal structures obtained from the RCSB Protein Data Bank and 350 chromosomal and plasmid homology models we generated from sequences obtained from the NCBI Protein Database...
November 22, 2016: Journal of Molecular Graphics & Modelling
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