keyword
https://read.qxmd.com/read/38534397/variation-of-structure-and-cellular-functions-of-type-ia-topoisomerases-across-the-tree-of-life
#21
REVIEW
Kemin Tan, Yuk-Ching Tse-Dinh
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers generated as replication or recombination intermediates. The subfamily of type IA topoisomerases are the only topoisomerases that can alter the interlinking of both DNA and RNA. In this article, we provide a review of the mechanisms by which four highly conserved N-terminal protein domains fold into a toroidal structure, enabling cleavage and religation of a single strand of DNA or RNA...
March 21, 2024: Cells
https://read.qxmd.com/read/38534242/simple-visual-point-of-care-sars-cov-2-detection-incorporating-recombinase-polymerase-amplification-and-target-dna-protein-crosslinking-enhanced-chemiluminescence
#22
JOURNAL ARTICLE
Hui Chen, Zhiyuan Zhuang, Naihan Xu, Ying Feng, Kaixin Fang, Chunyan Tan, Ying Tan
The ongoing COVID-19 pandemic, driven by persistent SARS-CoV-2 transmission, threatens human health worldwide, underscoring the urgent need for an efficient, low-cost, rapid SARS-CoV-2 detection method. Herein, we developed a point-of-care SARS-CoV-2 detection method incorporating recombinase polymerase amplification (RPA) and DNA-protein crosslinking chemiluminescence (DPCL) (RPADPCL). RPADPCL involves the crosslinking of biotinylated double-stranded RPA DNA products with horseradish peroxidase (HRP)-labeled streptavidin (SA-HRP)...
March 6, 2024: Biosensors
https://read.qxmd.com/read/38534228/ultrasensitive-label-free-voltammetric-detection-of-dibutyl-phthalate-based-on-poly-l-lysine-poly-3-4-ethylenedioxythiophene-porous-graphene-nanocomposite-and-molecularly-imprinted-polymers
#23
JOURNAL ARTICLE
Chuanxiang Zhang, Song Li, Lingxiao Tang, Shuo Li, Changchun Hu, Dan Zhang, Long Chao, Xueying Liu, Yimin Tan, Yan Deng
Development of an efficient technique for accurate and sensitive dibutyl phthalate (DBP) determination is crucial for food safety and environment protection. An ultrasensitive molecularly imprinted polymers (MIP) voltammetric sensor was herein engineered for the specific determination of DBP using poly-l-lysine/poly(3,4-ethylenedioxythiophene)/porous graphene nanocomposite (PLL/PEDOT-PG) and poly(o-phenylenediamine)-imprinted film as a label-free and sensing platform. Fabrication of PEDOT-PG nanocomposites was achieved through a simple liquid-liquid interfacial polymerization...
February 23, 2024: Biosensors
https://read.qxmd.com/read/38534191/patient-access-of-their-radiology-reports-before-and-after-implementation-of-21st-century-cures-act-information-blocking-provisions-at-a-large-multicampus-health-system
#24
JOURNAL ARTICLE
Jordan R Pollock, Skye A Buckner Petty, John J Schmitz, Jacob Varner, Allie M Metcalfe, Nelly Tan
Background: To implement provisions of the 21st Century Cures Act addressing information blocking, federal regulations mandated that health systems provide patients with immediate access to elements of their electronic health information, including imaging results. Objective: To compare patient access of radiology reports before and after implementation of the information-blocking provisions of the 21st Century Cures Act. Method: This retrospective study included patients who underwent outpatient imaging examinations from January 1, 2021, to December 31, 2022 at three campuses within a large health system...
March 27, 2024: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/38533928/trends-and-disparities-in-cardiovascular-death-in-sarcoidosis-a-population-based-retrospective-study-in-the-united-states-from-1999-to-2020
#25
JOURNAL ARTICLE
Min Choon Tan, Yong Hao Yeo, Noreen Mirza, Boon Jian San, Jian Liang Tan, Justin Z Lee, Joanne K Mazzarelli, Andrea M Russo
BACKGROUND: Despite significant cardiac involvement in sarcoidosis, real-world data on death due to cardiovascular disease among patients with sarcoidosis is not well established. METHODS AND RESULTS: We queried the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database for data on patients with sarcoidosis aged ≥25 years from 1999 to 2020. Diseases of the circulatory system except ischemic heart disease were listed as the underlying cause of death, and sarcoidosis was stated as a contributing cause of death...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533828/spin-degree-manipulation-for-one-dimensional-room-temperature-ferromagnetism-in-a-haldane-system
#26
JOURNAL ARTICLE
Pengfei Tan, Chuanhui Zhu, Xiaosheng Ni, Han-Qing Wu, Shuang Zhao, Tao Xia, Jinjin Yang, Tao Han, Mei-Huan Zhao, Yifeng Han, Yuanhua Xia, Zheng Deng, Muwei Wu, Dao-Xin Yao, Man-Rong Li
The intricate correlation between lattice geometry, topological behavior and charge degrees of freedom plays a key role in determining the physical and chemical properties of a quantum-magnetic system. Herein, we investigate the introduction of the unusual oxidation state as an alternative pathway to modulate the magnetic ground state in the well-known S = 1 Haldane system nickelate Y2 BaNiO5 (YBNO). YBNO is topologically reduced to incorporate d9 -Ni+ ( S = 1/2) in the one-dimensional Haldane chain system...
March 27, 2024: Materials Horizons
https://read.qxmd.com/read/38533686/immobilization-of-amino-site-into-a-pore-partitioned-metal-organic-framework-for-highly-efficient-separation-of-propyne-propylene
#27
JOURNAL ARTICLE
Yuhang Huang, Yanfei Feng, Yi Li, Kui Tan, Jie Tang, Junfeng Bai, Jingui Duan
Adsorptive separation of propyne/propylene (C3H4/C3H6) is a crucial yet complex process, however, it remains a great difficulty in developing porous materials that can meet the requirements for practical applications, particularly with an exceptional ability to bind and store trace amounts of C3H4. Functionalization of pore-partitioned metal-organic frameworks (ppMOFs) is methodically suited for this challenge owing to the possibility of dramatically increasing binding sites on highly porous and confined domains...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38533667/volatile-organic-compound-based-predictive-modeling-of-smoke-taint-in-wine
#28
JOURNAL ARTICLE
Cheng-En Tan, Bishnu Prasad Neupane, Yan Wen, Lik Xian Lim, Cristina Medina Plaza, Anita Oberholster, Ilias Tagkopoulos
Smoke taint in wine has become a critical issue in the wine industry due to its significant negative impact on wine quality. Data-driven approaches including univariate analysis and predictive modeling are applied to a data set containing concentrations of 20 VOCs in 48 grape samples and 56 corresponding wine samples with a taster-evaluated smoke taint index. The resulting models for predicting the smoke taint index of wines are highly predictive when using as inputs VOC concentrations after log conversion in both grapes and wines (Pearson Correlation Coefficient PCC = 0...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38533660/glymphatic-system-impairment-contributes-to-the-formation-of-brain-edema-after-ischemic-stroke
#29
JOURNAL ARTICLE
Juan Zhu, Jiaying Mo, Kewei Liu, Quanfeng Chen, Zheqi Li, Yihua He, Yuan Chang, Chuman Lin, Mingjia Yu, Yikai Xu, Xiangliang Tan, Kaibin Huang, Suyue Pan
BACKGROUND: Blood-brain barrier damage has traditionally been considered to determine the occurrence and development of poststroke brain edema, a devastating and life-threatening complication. However, no treatment strategy targeting blood-brain barrier damage has been proven clinically effective in ameliorating brain edema. METHODS: In mice with stroke models induced by transient middle cerebral artery occlusion (MCAO), the changes in glymphatic system (GS) function impairment were detected by ex vivo fluorescence imaging, 2-photon in vivo imaging, and magnetic resonance imaging within 1 week after MCAO, and the effects of GS impairment and recovery on the formation and resolution of brain edema were evaluated...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533619/amyloid-pathology-mediates-the-associations-between-plasma-fibrinogen-and-cognition-in-non-demented-adults
#30
JOURNAL ARTICLE
Li-Yun Ma, Jing-Hui Song, Pei-Yang Gao, Ya-Nan Ou, Yan Fu, Liang-Yu Huang, Zuo-Teng Wang, Dan-Dan Zhang, Rui-Ping Cui, Yin-Chu Mi, Lan Tan
Though previous studies revealed the potential associations of elevated levels of plasma fibrinogen with dementia, there is still limited understanding regarding the influence of Alzheimer's disease (AD) biomarkers on these associations. We sought to investigate the interrelationships among fibrinogen, cerebrospinal fluid (CSF) AD biomarkers, and cognition in non-demented adults. We included 1996 non-demented adults from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study and 337 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database...
March 27, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38533559/scleral-fixated-vs-iris-fixated-intraocular-lens-in-pediatric-ectopia-lentis-a-systematic-review
#31
REVIEW
Siti Halida Zoraida Soraya Alamsjah, Dian Estu Yulia, Sabrina Tan
Numerous intraocular lens (IOLs) options are available for treating pediatric ectopia lentis, and this paper reviews recent literature on pediatric ectopia lentis treatment with iris-fixated and scleral-fixated IOLs. A comprehensive search was undertaken on PubMed, Embase, ProQuest, Cochrane, Wiley, SCOPUS, and EBSCO. Studies published in the last ten years that met the inclusion criteria were included in this review. Seventeen studies exhibiting low to moderate risk of bias were included in this review, with eight on iris-fixated IOL (IFIOL), six on scleral-fixated IOL (SFIOL), and three on both IOLs...
March 27, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38533512/exploring-the-clinical-significance-of-il-38-correlation-with-pd-1-ctla-4-and-foxp3-in-colorectal-cancer-draining-lymph-nodes
#32
JOURNAL ARTICLE
Liuhong Yuan, Zhenyu Tan, Junjie Huang, Feier Chen, Brett D Hambly, Shisan Bao, Kun Tao
INTRODUCTION: Colorectal cancer (CRC) presents a substantial challenge characterized by unacceptably high mortality and morbidity, primarily attributed to delayed diagnosis and reliance on palliative care. The immune response of the host plays a pivotal role in carcinogenesis, with IL-38 emerging as a potential protective factor in CRC. However, the precise involvement of IL-38 among various leucocytes, its interactions with PD-1/PD-L1, and its impact on metastasis require further elucidation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533511/bones-on-fire-illuminating-osteomyelitis-through-the-radiant-lens-of-18-f-fdg-pet-ct
#33
REVIEW
Mei Yang, Quanhui Tan, Zhenghao Tang
Osteomyelitis is an inflammatory process that is caused by an infecting microorganism and leads to progressive bone destruction and loss. Osteomyelitis can occur at any age and can involve any bone. The infection can be limited to a single portion of the bone or can involve several regions, such as marrow, cortex, periosteum, and the surrounding soft tissue. Early and accurate diagnosis plays a crucial role in reducing unnecessary treatment measures, improving the patient's prognosis, and minimizing time and financial costs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533497/the-interaction-of-lipocalin-2-and-astrocytes-in-neuroinflammation-mechanisms-and-therapeutic-application
#34
REVIEW
Qianqian Tan, Chenxi Zhang, Xiuqin Rao, Wei Wan, Wei Lin, Shupeng Huang, Jun Ying, Yue Lin, Fuzhou Hua
Neuroinflammation is a common pathological process in various neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, and others. It involves the activation of glial cells, particularly astrocytes, and the release of inflammatory mediators. Lipocalin-2 (Lcn-2) is a secretory protein mainly secreted by activated astrocytes, which can affect neuroinflammation through various pathways. It can also act as a pro-inflammatory factor by modulating astrocyte activation and polarization through different signaling pathways, such as NF-κB, and JAK-STAT, amplifying the inflammatory response and aggravating neural injury...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533377/distinct-cellular-microenvironment-with-cytotypic-effects-regulates-orderly-regeneration-of-vascular-tissues
#35
JOURNAL ARTICLE
Jian Wang, Xun Yang, Miaomiao Xu, Hui Liu, Lijun Liu, Zhikai Tan
Regeneration of the architecturally complex blood vascular system requires precise temporal and spatial control of cell behaviours. Additional components must be integrated into the structure to achieve clinical success for in situ tissue engineering. Consequently, this study proposed a universal method for including any substrate type in vascular cell extracellular matrices (VCEM) via regulating selective adhesion to promote vascular tissue regeneration. The results uncovered that the VCEM worked as cell adhesion substrates, exhibited cell type specificity, and functioned as an address signal for recognition by vascular cells, which resulted in matching with the determined cells...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38533305/the-primary-prevention-of-pancreatic-fistula-using-a-vascularised-rectus-abdominis-muscle-flap-a-porcine-model
#36
JOURNAL ARTICLE
A W J Wong, N H S Sim, J H Kam, R Rajarethinam, B K Tan, A Y H Tan
BACKGROUND: A pancreatic fistula is one of the most devastating complications following a Whipple's procedure. Fistula rates remain high despite various modifications to surgical techniques. We propose the use of a vascularised muscle flap in the primary prevention of pancreatic fistulas. METHOD: A distal pancreatectomy was performed on 5 pigs in our porcine model. A pancreaticojejunal (PJ) anastomotic leak was simulated. The pigs were divided into treatment (4 pigs) and control groups (1 pig)...
June 2024: JPRAS Open
https://read.qxmd.com/read/38533261/potential-pharmacological-mechanisms-of-tanshinone-iia-in-the-treatment-of-human-neuroblastoma-based-on-network-pharmacological-and-molecular-docking-technology
#37
JOURNAL ARTICLE
Ning Tang, Yan Wang, Jiarui Miao, Yang Zhao, Yue Cao, Wentao Sun, Jingke Zhang, Hua Sui, Bing Li
Tanshinone IIA (Tan-IIA) is the main bioactive component of Chinese herbal medicine salvia miltiorrhiza (Danshen). Sodium sulfonate of Tan-IIA is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tan-IIA also has inhibitory effects on tumor cells such as gastric cancer, but its therapeutic effect and mechanism on human neuroblastoma have not been evaluated, so its pharmacological mechanism is systematically evaluated by the combined method of network pharmacology and molecular docking...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533058/image-detection-of-aortic-dissection-complications-based-on-multi-scale-feature-fusion
#38
JOURNAL ARTICLE
Yun Tan, Zhenxu Wang, Ling Tan, Chunzhi Li, Chao Deng, Jingyu Li, Hao Tang, Jiaohua Qin
BACKGROUND: Aortic dissection refers to the true and false two-lumen separation of the aortic wall, in which the blood in the aortic lumen enters the aortic mesomembrane from the tear of the aortic intima to separate the mesomembrane and expand along the long axis of the aorta. PURPOSE: In view of the problems of individual differences, complex complications and many small targets in clinical aortic dissection detection, this paper proposes a convolution neural network MFF-FPN (Multi-scale Feature Fusion based Feature Pyramid Network) for the detection of aortic dissection complications...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532898/cushing-s-syndrome-during-pregnancy-two-case-reports
#39
Sumita Cholekho, Yuke Liu, Huiwen Tan
BACKGROUND: Cushing's syndrome (CS) during pregnancy is a rare endocrine disorder characterized by hypercortisolism, which is significantly associated with maternal-fetal complications. Despite its rarity, CS during pregnancy may be related to a high risk of complications for both the mother and fetus.The aim of the present case study is to update the diagnostic approach to CS during pregnancy and the therapeutic strategies for this medical condition to minimize maternal-fetal complications...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532885/regulation-of-interstitial-fluid-flow-in-adventitia-along-vasculature-by-heartbeat-and-respiration
#40
JOURNAL ARTICLE
Hongyi Li, Bei Li, Wenqi Luo, Xi Qi, You Hao, Chaozhi Yang, Wenqing Li, Jiazheng Li, Zhen Hua, Tan Guo, Zhijian Zheng, Xue Yu, Lei Liu, Jianping Zhao, Tiantian Li, Dahai Huang, Jun Hu, Zongmin Li, Fang Wang, Hua Li, Chao Ma, Fusui Ji
Converging studies showed interstitial fluid (ISF) adjacent to blood vessels flows in adventitia along vasculature into heart and lungs. We aim to reveal circulatory pathways and regulatory mechanism of such adventitial ISF flow in rat model. By MRI, real-time fluorescent imaging, micro-CT, and histological analysis, ISF was found to flow in adventitial matrix surrounded by fascia and along systemic vessels into heart, then flow into lungs via pulmonary arteries and back to heart via pulmonary veins, which was neither perivascular tissues nor blood or lymphatic vessels...
April 19, 2024: IScience
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