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https://www.readbyqxmd.com/read/29040936/chemical-profiling-and-quantification-of-dan-deng-tong-nao-capsule-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-hybrid-quadruple-orbitrap-mass-spectrometry
#1
Xiao-Jing Lv, Zhi Sun, Pei-Le Wang, Jing Yang, Tan-Ye Xu, Qing-Quan Jia, Da-Wei Li, Fang-Yi Su, Zhen-Feng Zhu, Jian Kang, Xiao-Jian Zhang
Dan-Deng-Tong-Nao capsule (DDTN) was a traditional Chinese medicine (TCM) formula, and has been widely used for the treatment of stroke clinically which caused by blood stasis. However, the bioactive substances and mechanism are unclear because of the complex compositions in DDTN. In this research, An ultra high-performance liquid chromatography (UHPLC) coupled with hybrid quadruple-orbitrap mass spectrometry (Q-Orbitrap MS) method was utilized to identify the chemical constituents of DDTN. In total, 102 compounds including diterpenes, lactones, flavonoids, and phenolic acids were identified by the accurate masses and fragmentation pathways, and 18 of them were unambiguously determined by comparison of reference standards...
October 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040920/ancestry-prediction-in-singapore-population-samples-using-the-illumina-forenseq-kit
#2
Anantharaman Ramani, Yongxun Wong, Si Zhen Tan, Bing Hong Shue, Christopher Syn
The ability to predict bio-geographic ancestry can be valuable to generate investigative leads towards solving crimes. Ancestry informative marker (AIM) sets include large numbers of SNPs to predict an ancestral population. Massively parallel sequencing has enabled forensic laboratories to genotype a large number of such markers in a single assay. Illumina's ForenSeq DNA Signature Kit includes the ancestry informative SNPs reported by Kidd et al. In this study, the ancestry prediction capabilities of the ForenSeq kit through sequencing on the MiSeq FGx were evaluated in 1030 unrelated Singapore population samples of Chinese, Malay and Indian origin...
August 15, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29040892/majority-of-flat-epithelial-atypia-diagnosed-on-biopsy-do-not-require-surgical-excision
#3
Patrick Mun Yew Chan, Niketa Chotai, Eileen Shujuan Lai, Pei Yi Sin, Juliana Chen, Sarah Qinghui Lu, Mui Heng Goh, Bee Kiang Chong, Bernard Chi Shern Ho, Ern Yu Tan
BACKGROUND: Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA on biopsy and evaluated potential predictive factors. METHODS: Retrospective review was done of 194 women who underwent biopsy of indeterminate lesions (total 195 lesions) that were diagnosed as FEA. The review covered a 10-year period...
October 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29040672/unsupervised-learning-of-spatiotemporal-interictal-discharges-in-focal-epilepsy
#4
Maxime O Baud, Jonathan K Kleen, Gopala K Anumanchipalli, Liberty S Hamilton, Yee-Leng Tan, Robert Knowlton, Edward F Chang
BACKGROUND: Interictal epileptiform discharges are an important biomarker for localization of focal epilepsy, especially in patients who undergo chronic intracranial monitoring. Manual detection of these pathophysiological events is cumbersome, but is still superior to current rule-based approaches in most automated algorithms. OBJECTIVE: To develop an unsupervised machine-learning algorithm for the improved, automated detection and localization of interictal epileptiform discharges based on spatiotemporal pattern recognition...
October 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29040605/negative-assortative-mating-in-the-white-throated-sparrow
#5
Philip W Hedrick, Elaina M Tuttle, Rusty A Gonser
Non-random mating based on phenotype has been observed in a number of organisms, but a very high proportion of these examples are of assortative mating. The strongest example of negative-assortative mating is for white-striped versus tan-striped crown in the white-throated sparrow, where about 98% of the observed pairings (mated pairs or social pairs) are between mates with different phenotypes and the correlation between mating types is -0.964. Although non-random mating has been explored theoretically for decades, these models have generally not focused on specific well-documented examples...
October 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#6
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
September 27, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040400/treatment-of-gastrocnemius-muscle-hypertrophy-with-botulinum-toxin-injection-followed-by-magnetic-resonance-imaging-assessment-and-3-dimensional-evaluation
#7
Melia Bogari, Andy Tan, Yu Xin, Gang Chai, Li Lin, Peiru Min, Yan Zhang, Yixin Zhang
Background: Hypertrophy of the gastrocnemius muscle is considered to be a hindrance to lower leg beauty in the Asian aesthetic market. A noninvasive technique that has been gaining recognition involves botulinum toxin A injection; however, there are no proper guidelines or standardized protocols for the administration of botulinum toxin to correct gastrocnemius hypertrophy. Objectives: This study sought to determine the most effective botulinum toxin injection method for correcting the contour of the lower leg calf, as well as to determine the dose that can produce the maximum effect in meeting the demands of the physician and patient...
August 10, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040012/outcome-of-acute-lymphoblastic-leukemia-in-children-with-down-syndrome-polish-pediatric-leukemia-and-lymphoma-study-group-report
#8
Joanna Zawitkowska, Teresa Odój, Katarzyna Drabko, Agnieszka Zaucha-Prażmo, Julia Rudnicka, Michał Romiszewski, Michał Matysiak, Kinga Kwiecińska, Magdalena Ćwiklińska, Walentyna Balwierz, Joanna Owoc-Lempach, Katarzyna Derwich, Jacek Wachowiak, Maciej Niedźwiecki, Elżbieta Adamkiewicz-Drożyńska, Joanna Trelińska, Wojciech Młynarski, Andrzej Kołtan, Mariusz Wysocki, Renata Tomaszewska, Tomasz Szczepański, Marcin Płonowski, Maryna Krawczuk-Rybak, Tomasz Ociepa, Tomasz Urasiński, Agnieszka Mizia-Malarz, Grażyna Sobol-Milejska, Grażyna Karolczyk, Jerzy Kowalczyk
Children with Down syndrome (DS) have a 20-fold increased risk of developing leukemia compared with the general population. The aim of the study was to analyze the outcome of patients diagnosed with Down syndrome and acute lymphoblastic leukemia (ALL) in Poland between the years 2003 and 2010. A total of 1848 children were diagnosed with ALL (810 females and 1038 males). Of those, 41 (2.2%) had DS. The children were classified into three risk groups: a standard-risk group-14 patients, an intermediate-risk group-24, a high-risk group-3...
October 17, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29039959/preparation-of-1-2-oxazetidines-from-styrenes-and-arylamines-via-a-peroxide-mediated-2-1-1-cycloaddition-reaction
#9
Weibing Liu, Cui Chen, Peng Zhou, Hua Tan
The first regioselective synthesis of polysubstituted 1,2-oxazetidines, based on the [2 + 1 + 1] radical tandem cycloaddition of styrenes, arylamines, and tert-butyl hydroperoxide (TBHP), is described. This simple and direct method allows the synthesis of 1,2-oxazetidines with a broad substrate scope from easily accessible materials. TBHP was employed in this conversion not only as the oxidant but also as the source of "O" for the carbonyl group in the products.
October 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29036833/gsk3%C3%AE-aggravates-the-depression-symptoms-in-chronic-stress-mouse-model
#10
Hong Peng, Hong-Bin Wang, Ling Wang, Bing Zhou, Xiao-Yong Li, Jian Tan
Depression caused by genetic and environmental factors is a kind of complicated disease. Here, we find that Gsk3β is highly expressed and phosphorylated in the brain of chronic stress mouse. Inhibition of Gsk3β lead to decreased depression like symptoms which is manifested in open field test, tail-suspension test, forced-swim test and novelty suppressed feeding test. Besides, accompanied by activated Gsk3β, we find that β-catenin is attenuated, and its target genes Cyclin D1 and c-Myc are down-regulated...
October 13, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29036694/efficient-modulation-of-photosynthetic-apparatus-confers-desiccation-tolerance-in-the-resurrection-plant-boea-hygrometrica
#11
Tinghong Tan, Yanni Sun, Shishuai Luo, Chao Zhang, Huapeng Zhou, Honghui Lin
Boea hygrometrica (B. hygrometrica) can tolerate severe desiccation and resume photosynthetic activity rapidly upon water availability. However, little is known about the mechanisms by which B. hygrometrica adapts to dehydration and resumes competence upon rehydration. Here we determined how B. hygrometrica to deal with oxidative stress, excessive excitation/electron pressures as well as photosynthetic apparatus modulation during dehydration/rehydration. By measuring ROS generation and scavenging efficiency, we found that B...
September 19, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036605/survey-of-laboratory-practices-for-diagnosis-of-fungal-infection-in-seven-asian-countries-an-asia-fungal-working-group-afwg-initiative
#12
Ariya Chindamporn, Arunaloke Chakrabarti, Ruoyu Li, Pei-Lun Sun, Ban-Hock Tan, Mitzi Chua, Retno Wahyuningsih, Atul Patel, Zhengyin Liu, Yee-Chun Chen, Methee Chayakulkeeree
An online survey of mycology laboratories in seven Asian countries was conducted to assess the status, competence, and services available. Country representatives from the Asia Fungal Working Group (AFWG) contacted as many laboratories performing mycology diagnosis as possible in their respective countries, requesting that the laboratory heads complete the online survey. In total, 241 laboratories responded, including 71 in China, 104 in India, 11 in Indonesia, 26 in the Philippines, four in Singapore, 18 in Taiwan, and seven in Thailand...
September 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29036482/effective-dose-due-to-terrestrial-gamma-radiation-estimated-in-southern-vietnam-by-car-borne-survey-technique
#13
Tan Van Le, Kazumasa Inoue, Hiroshi Tsuruoka, Makoto Fujisawa, Moeko Arai, Linh Dai Hung Nguyen, Siriprapa Somboon, Masahiro Fukushi
Absorbed dose rates in air from natural radionuclides were measured by a car-borne survey in southern Vietnam. The mean absorbed dose rate in air for southern Vietnam, which consists of the south-east region and the Mekong River Delta region, was 64 ± 18 nGy h-1, while rates for the two regions were 61 ± 17 and 66 ± 19 nGy h-1, respectively. These dose rates were respectively 1.2, 2.1 and 0.9 times the measured values that were calculated on the basis of activity concentrations of soil samples in a previous study...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036420/turbofold-ii-rna-structural-alignment-and-secondary-structure-prediction-informed-by-multiple-homologs
#14
Zhen Tan, Yinghan Fu, Gaurav Sharma, David H Mathews
This paper presents TurboFold II, an extension of the TurboFold algorithm for predicting secondary structures for multiple RNA homologs. TurboFold II augments the structure prediction capabilities of TurboFold by additionally providing multiple sequence alignments. Probabilities for alignment of nucleotide positions between all pairs of input sequences are iteratively estimated in TurboFold II by incorporating information from both the sequence identity and secondary structures. A multiple sequence alignment is obtained from these probabilities by using a probabilistic consistency transformation and a hierarchically computed guide tree...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036267/electrical-activity-of-the-heart-under-pressure
#15
Alberto Avolio, Isabella Tan, Mark Butlin, Edward Barin
No abstract text is available yet for this article.
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036266/alterations-in-no-ros-ratio-and-expression-of-trx1-and-prdx2-in-isoproterenol-induced-cardiac-hypertrophy
#16
Hao Su, Marco Pistolozzi, Xingjuan Shi, Xiaoou Sun, Wen Tan
The development of cardiac hypertrophy is a complicated process, which undergoes a transition from compensatory hypertrophy to heart failure, and the identification of new biomarkers and targets for this disease is greatly needed. Here we investigated the development of isoproterenol (ISO)-induced cardiac hypertrophy in an in vitro experimental model. After the induction of hypertrophy with ISO treatment in H9c2 cells, cell surface area, cell viability, cellular reactive oxygen species (ROS), and nitric oxide (NO) levels were tested...
October 3, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036138/double-distortion-correction-method-in-a-catadioptric-vision-system-with-a-conic-mirror
#17
Fuqiang Zhou, Xin Chen, Haishu Tan
Because of the low calibration precision caused by reflector distortion in catadioptric vision systems with conic mirrors, we proposed a double distortion correction model based on the panoramic image rectification. The lens distortion and the reflector distortion are analyzed independently in the mathematic model of the double distortion correction. Moreover, the modified model in this paper added the trigonometric functions into the polynomial model to solve the combined distortion. Additionally, extensive experiments, both simulative and real data, have been carried out and show that the proposed model achieves comparable measurement accuracy in contrast with the traditional distortion method...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036048/laser-diode-side-pumped-nd-yvo4-microchip-laser-with-film-etched-microcavity-mirrors
#18
Jiyang Li, Yanxiong Niu, Sanbin Chen, Yidong Tan
Microchip lasers are applied as the light sources on various occasions with the end-pumping scheme. However, the vibration, the temperature drift, or the mechanical deformation of the pumping light in laser diodes in the end-pumping scheme will lead to instability in the microchip laser output, which causes errors and malfunctioning in the optic systems. In this paper, the side-pumping scheme is applied for improving the disturbance-resisting ability of the microchip laser. The transverse mode and the frequency purity of the laser output are tested...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035975/breath-hydrogen-testing-in-east-and-southeast-asia
#19
Chu Kion Yao, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Breath hydrogen tests are popular, noninvasive tests for the assessment of carbohydrate fermentation in patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). There is limited information regarding the utility of breath hydrogen and methane tests in IBS and FD patients in East and Southeast Asia. This review aims to summarize current literature about common indications of breath testing in this region, the genesis of functional gastrointestinal symptoms by provocative breath testing and provide suggestions for correct use...
October 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29035891/inhibiting-ros-tfeb-dependent-autophagy-enhances-salidroside-induced-apoptosis-in-human-chondrosarcoma-cells
#20
Wei Zeng, Tao Xiao, Anlie Cai, Weiliang Cai, Huanhuan Liu, Jingling Liu, Jie Li, Miduo Tan, Li Xie, Ying Liu, Xiangcheng Yang, Yi Long
BACKGROUND/AIMS: Autophagy modulation has been considered a potential therapeutic strategy for human chondrosarcoma, and a previous study indicated that salidroside exhibits significant anti-carcinogenic activity. However, the ability of salidroside to induce autophagy and its role in human chondrosarcoma cell death remains unclear. METHODS: We exposed SW1353 cells to different concentrations of salidroside (0.5, 1 and 2 mM) for 24 h. RT-PCR, Western-blotting, Immunocytofluorescence, and Luciferase Reporter Assays were used to evaluate whether salidroside activated the TFEB-dependent autophagy...
October 16, 2017: Cellular Physiology and Biochemistry
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