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https://www.readbyqxmd.com/read/29240854/upregulation-of-extracellular-matrix-genes-corroborates-clinical-efcacy-of-human-fibroblast-derived-growth-factors-in-skin-rejuvenation
#1
Kuniko Kadoya, Elizabeth T Makino, Lily I Jiang, Michael Bachelor, Robin Chung, Priscilla Tan, Tsing Cheng, Gail K Naughton, Rahul C Mehta
<p>Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including collagens and elas-tin...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240820/age-related-nomograms-for-antral-follicle-count-and-anti-mullerian-hormone-for-subfertile-chinese-women-in-singapore
#2
See Ling Loy, Yin Bun Cheung, Marielle Valerie Fortier, Chiou Li Ong, Heng Hao Tan, Sadhana Nadarajah, Jerry Kok Yen Chan, Veronique Viardot-Foucault
BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman's ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women's and Children's Hospital, Singapore...
2017: PloS One
https://www.readbyqxmd.com/read/29240098/reduced-basis-boundary-element-method-for-fast-electromagnetic-field-computation
#3
Yating Shi, Xiuguo Chen, Yinyin Tan, Hao Jiang, Shiyuan Liu
In this work, we combine conventional boundary element method (BEM) with the reduced-basis method (RBM) and propose a reduced-basis boundary element method (RB-BEM) to realize efficient modeling for parameterized electromagnetic scattering problems of dielectric scatterers. The RB-BEM allows for splitting the modeling process into a parameter-independent offline part and parameter-dependent online part, and replacing the high-dimensional original model obtained by conventional BEM with a low-dimensional reduced-basis model to improve computational efficiency of the online part...
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29240020/association-study-of-fgf18-with-developmental-dyslexia-in-chinese-population
#4
Huan Chen, Yuxi Zhou, Zeng Ge, Qian Li, Qinsheng Sun, Liyuan Zheng, Hong Lv, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools...
December 12, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29239864/trabeculectomy-outcomes-after-glaucoma-drainage-device-surgery
#5
Reza Alizadeh, Handan Akil, James Tan, Simon K Law, Joseph Caprioli
PURPOSE: To evaluate outcomes of trabeculectomy with adjunctive Mitomycin-C (MMC) in patients with uncontrolled intraocular pressure (IOP) after glaucoma drainage device implantation (GDD). METHODS: Consecutive patients who had undergone a trabeculectomy after GDD were reviewed. The primary outcome was surgical success with stratified IOP targets based on the following criteria: (A) IOP <18▒mm Hg and IOP reduction of 20%; (B) IOP <15▒mm Hg and IOP reduction of 25%; (C) IOP <12▒mm Hg and IOP reduction of 30%...
December 12, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29239808/drug-class-renal-elimination-and-outcomes-of-direct-oral-anticoagulants-in-asian-patients-a-meta-analysis
#6
Kang-Ling Wang, Chun-Chih Chiu, Robert P Giugliano, Doreen Su-Yin Tan, Chun-Yi Lin, En-Yu Lai, Shinya Goto, Chern-En Chiang
BACKGROUND: Direct oral anticoagulants (DOACs) have a better risk benefit profile in Asian patients with atrial fibrillation (AF). Whether treatment effects could be modified by drug class and dependency on renal elimination of studied agents has not yet been explored. METHODS: We searched PubMed, CENTRAL, and CINAHL databases through November 2016 for phase III randomized controlled trials comparing DOACs with warfarin in patients with AF. Efficacy and safety outcomes were pooled according to drug class and dependency on renal elimination of DOACs and were compared with the Mantel-Haenszel fixed-effects model...
November 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29239781/erratum-to-reconstruction-design-before-tumour-resection-a-new-concept-of-through-and-through-cheek-defect-reconstruction-oral-oncol-74-2017-123-129
#7
Zhao-Jian Gong, Zhen-Hu Ren, Kai Wang, Hong-Yu Tan, Sheng Zhang, Han-Jiang Wu
No abstract text is available yet for this article.
November 24, 2017: Oral Oncology
https://www.readbyqxmd.com/read/29239757/design-of-back-streaming-white-neutron-beam-line-at-csns
#8
L Y Zhang, H T Jing, J Y Tang, Q Li, X C Ruan, J Ren, C J Ning, Y J Yu, Z X Tan, P C Wang, Y C He, X Q Wang
A white neutron beam line using back-streaming neutrons from the spallation target is under construction at China Spallation Neutron Source (CSNS). Different spectrometers, to be installed in the so-called Back-n beam line for nuclear data measurements, are also being developed in phases. The physical design of the beam line is carried out with the help of a complicated collimation system and a sophisticated neutron dump, taking the overview of the neutron beam characteristics into account. This includes energy spectrum, flux and time structure, the optimizations of neutron beam spots and in-hall background...
November 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29239274/magnetic-resonance-feature-of-paintbrush-borders-sign-as-a-novel-way-to-predict-recurrence-of-giant-cell-tumor-of-bone-after-curettage-a-pilot-study
#9
Yifeng He, Jun Wang, Ji Zhang, Lianjun Du, Yong Lu, Jianqiang Xu, Fei Yuan, Yimin Tan, Xiaoyi Ding
Objective To identify the prognostic factors for local recurrence of giant cell tumor of bone (GCTB) through assessment of the preoperative imaging features of the tumor border. Methods Patients with GCTBs treated with intralesional procedures in the proximal tibia and distal femur were prospectively enrolled and then followed up for at least 2 years. The GCTBs were grouped according to their preoperative imaging features. GCTBs treated with en bloc resection were enrolled for investigation of the pathologic basis of specific imaging features...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239247/correlations-between-polymorphisms-in-the-uridine-diphosphate-glucuronosyltransferase-1a-and-c-c-motif-chemokine-receptor-5-genes-and-infection-with-the-hepatitis-b-virus-in-three-ethnic-groups-in-china
#10
Chan Zhang, Yan He, Ke-Ren Shan, Kui Tan, Ting Zhang, Chan-Juan Wang, Zhi-Zhong Guan
Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239135/oxymatrine-inhibits-non-small-cell-lung-cancer-via-suppression-of-egfr-signaling-pathway
#11
Wei Li, Xinfang Yu, Shiming Tan, Wenbin Liu, Li Zhou, Haidan Liu
Epidermal growth factor receptor (EGFR) plays a crucial role in human non-small cell lung cancer (NSCLC) tumorigenesis. In this study, oxymatrine was identified as an EGFR signaling pathway inhibitor in NSCLC. Oxymatrine inhibited anchorage-dependent and independent growth of NSCLC cell lines but had no cytotoxicity in normal lung cells. We found that exposure to oxymatrine not only suppressed the activity of wild-type EGFR but also inhibited the activation of exon 19 deletion and L858R/T790M mutated EGFR. Flow cytometry analysis suggested that oxymatrine-induced cell cycle G0/G1 arrest was dependent on EGFR-Akt signaling...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29239097/spatially-probed-plasmonic-photothermic-nanoheater-enhanced-hybrid-polymeric-metallic-pvdf-ag-nanogenerator
#12
Chi Hao Liow, Xin Lu, Chuan Fu Tan, Kwok Hoe Chan, Kaiyang Zeng, Shuzhou Li, Ghim Wei Ho
Surface plasmon-based photonics offers exciting opportunities to enable fine control of the site, span, and extent of mechanical harvesting. However, the interaction between plasmonic photothermic and piezoresponse still remains underexplored. Here, spatially localized and controllable piezoresponse of a hybrid self-polarized polymeric-metallic system that correlates to plasmonic light-to-heat modulation of the local strain is demonstrated. The piezoresponse is associated to the localized plasmons that serve as efficient nanoheaters leading to self-regulated strain via thermal expansion of the electroactive polymer...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238873/insights-into-the-generation-of-monoclonal-antibody-acidic-charge-variants-during-chinese-hamster-ovary-cell-cultures
#13
Hongping Tang, Shiwei Miao, Xintao Zhang, Li Fan, Xuping Liu, Wen-Song Tan, Liang Zhao
Charge variation is one of the most important heterogeneities during monoclonal antibody (mAb) manufacturing and this study presents insights into the generation of acidic charge variants during cell culture processes. Since acidic variants generate both intracellularly and extracellularly, main charge fraction collected by weak cation exchange chromatography (WCX) was incubated in harvested cell supernatant (HCS) to simulate and investigate the extracellular process firstly. It is found that the main fraction was degraded rapidly into acidic variants rather than basic variants extracellularly, and the degradation sites were located in both Fab and Fc fragments indicated by papain digestion...
December 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29238868/early-experience-and-lessons-learnt-with-customized-fenestrated-thoracic-endovascular-aortic-reconstruction-for-aortic-arch-pathology-in-an-asian-population
#14
Glenn Wei Leong Tan, Lawrence Quek, Bien Peng Tan, Uei Pua
PURPOSE: Thoracic endovascular aortic repair (TEVAR) is the preferred treatment of descending thoracic aorta pathology. However, TEVAR in the aortic arch remains challenging. Customized fenestrated TEVAR (fTEVAR) allows extension of the proximal seal zone, while preserving the involved supra-aortic vessels. There is a paucity of information on fTEVAR; hence, we aim to evaluate our early experience and lessons learnt with fTEVAR in the aortic arch. METHODS: This is a retrospective single-centre review of fTEVAR endografts for aortic arch pathology over 24 months...
December 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29238541/how-beta-diversity-and-the-underlying-causes-vary-with-sampling-scales-in-the-changbai-mountain-forests
#15
Lingzhao Tan, Chunyu Fan, Chunyu Zhang, Klaus von Gadow, Xiuhua Fan
This study aims to establish a relationship between the sampling scale and tree species beta diversity temperate forests and to identify the underlying causes of beta diversity at different sampling scales. The data were obtained from three large observational study areas in the Changbai mountain region in northeastern China. All trees with a dbh ≥1 cm were stem-mapped and measured. The beta diversity was calculated for four different grain sizes, and the associated variances were partitioned into components explained by environmental and spatial variables to determine the contributions of environmental filtering and dispersal limitation to beta diversity...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238205/predictive-value-of-interim-pet-ct-visual-interpretation-in-the-prognosis-of-patients-with-aggressive-non-hodgkin-s-lymphoma
#16
Cheng-Cheng Liao, Yun-Ying Qin, Xiao-Hong Tan, Jia-Jie Hu, Qi Tang, Yan Rong, Hong Cen, Le-Qun Li
Objective: The objective of the study was to evaluate the prognostic value of positron emission tomography (PET)/computed tomography (CT) visual interpretation in patients with aggressive non-Hodgkin's lymphoma (NHL) using a meta-analysis and systematic review. Methods: Using the PubMed, Embase, and Web of Science databases, we performed a systematic review of the use of visual evaluation mid-chemotherapy to evaluate the prognosis of aggressive NHL in studies published up to May 2017...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29238177/the-mediating-role-of-psychological-symptoms-on-falls-risk-among-older-adults-with-osteoarthritis
#17
Sumaiyah Mat, Chin Teck Ng, Farhana Fadzil, Faizatul Izza Rozalli, Maw Pin Tan
The purpose of this study was to investigate the role of fear of falling (FoF) and psychological symptoms in explaining the relationship between osteoarthritis (OA) symptom severity and falls. Individuals aged ≥65 years with ≥2 falls or ≥1 injurious fall over the past 12 months were included in the falls group, while volunteers aged ≥65 years with no history of falls over 12 months were recruited as controls. The presence of lower extremity OA was determined radiologically and clinically. Severity of symptoms was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29237822/potassium-regulated-distal-tubule-wnk-bodies-are-kidney-specific-wnk1-dependent
#18
Cary R Boyd-Shiwarski, Daniel J Shiwarski, Ankita Roy, Lubika J Nkashama, Hima N Namboodiri, Jian Xie, Kara L McClain, Allison Marciszyn, Thomas R Kleyman, Roderick J Tan, Donna B Stolz, Manojkumar A Puthenveedu, Chou-Long Huang, Arohan R Subramanya
With-No-Lysine (WNK) kinases coordinate volume and potassium homeostasis by regulating renal tubular electrolyte transport. In the distal convoluted tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate into large discrete foci, which we call "WNK bodies." Though these structures have been reported previously, the mechanisms that drive their assembly remain obscure. Here, we show that kidney-specific WNK1 (KS-WNK1), a truncated kinase-defective WNK1 isoform that is highly expressed in the DCT, is critical for WNK body formation...
December 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29237710/short-term-outcomes-and-factors-associated-with-adverse-events-among-adults-discharged-from-the-emergency-department-after-treatment-for-acute-heart-failure
#19
Dana R Sax, Dustin G Mark, Renee Y Hsia, Thida C Tan, Grace H Tabada, Alan S Go
BACKGROUND: Although 80% of patients with heart failure seen in the emergency department (ED) are admitted, less is known about short-term outcomes and demand for services among discharged patients. METHODS AND RESULTS: We examined adult members of a large integrated delivery system who visited an ED for acute heart failure and were discharged from January 1, 2013, through September 30, 2014. The primary outcome was a composite of repeat ED visit, hospital admission, or death within 7 days of discharge...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29237666/spigelian-hernia-and-pitfalls-of-postoperative-anticoagulation
#20
Xiaotong Cheryl Tan, Sunny Nalavenkata, Michael Yunaev
Spigelian hernias are a rare lateral ventral abdominal hernia that carry a high risk of strangulation due to their smaller sizes, and require surgical intervention. In more complex cases involving an anticoagulated patient, perioperative management of anticoagulation must be monitored and reviewed to avoid potential pitfalls. We present an 81-year-old woman who presented with right groin pain, and was requiring warfarin anticoagulation due to her cardiac history. The spigelian hernia was diagnosed and reduced laparoscopically, and the defect was repaired and reinforced by mesh...
December 13, 2017: BMJ Case Reports
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