keyword
https://read.qxmd.com/read/38474363/lamin-a-c-and-pi-4-5-p2-a-novel-complex-in-the-cell-nucleus
#21
JOURNAL ARTICLE
Sara Escudeiro-Lopes, Vlada V Filimonenko, Lenka Jarolimová, Pavel Hozák
Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations. A portion of phosphorylated lamin A/C localizes to the nuclear interior in interphase, forming a lamin A/C pool with specific properties and distinct functions. Nucleoplasmic lamin A/C molecular functions are mainly dependent on its binding partners; therefore, revealing new interactions could give us new clues on the lamin A/C mechanism of action...
February 25, 2024: Cells
https://read.qxmd.com/read/38473674/the-influence-of-flame-exposure-and-solid-particle-erosion-on-tensile-strength-of-cfrp-substrate-with-manufactured-protective-coating
#22
JOURNAL ARTICLE
Przemysław Golewski, Michał Budka
This paper presents the results of laboratory tests for new materials made of a carbon fibre-reinforced polymer (CFRP) composite with a single-sided protective coating. The protective coatings were made of five different powders-Al2 O3 , aluminium, quartz sand, crystalline silica and copper-laminated in a single process during curing of the prepreg substrate with an epoxy matrix. The specimens were subjected to flame exposure and solid particle erosion tests, followed by uniaxial tensile tests. A digital image correlation (DIC) system was used to observe the damage location and deformation of the specimens...
March 5, 2024: Materials
https://read.qxmd.com/read/38473587/spring-in-prediction-of-cfrp-part-using-coupled-analysis-of-forming-and-cooling-processes-in-stamping
#23
JOURNAL ARTICLE
Jae-Chang Ryu, Chan-Joo Lee, Jin-Seok Jang, Dae-Cheol Ko
The spring-in phenomenon of the composite parts can affect the assembly process. This study aims to predict the spring-in phenomenon of a carbon fiber reinforced plastic (CFRP) part. Here, we predict the spring-in of the CFRP part using a coupled analysis of the forming and cooling processes during the stamping process. First, a simulation of the entire forming process, such as the transfer of the composite laminate, gravity analysis, and forming was performed to obtain the temperature distribution of the CFRP part...
February 28, 2024: Materials
https://read.qxmd.com/read/38473575/study-on-thin-lamination-of-carbon-fiber-based-on-mechanical-broadening
#24
JOURNAL ARTICLE
Yanlei Chen, Yanbo Hui, Dengjie Zhu, Xingle Li, Hongxiao Wang
Carbon fiber has excellent mechanical properties and plays an important role in modern industry. However, due to the complexity of the carbon fiber widening process, the industrial application of carbon fiber is limited. By designing the carbon fiber widening equipment of automaton, the relationship between the widening width of carbon fiber and the process parameters is studied, and the optimum developing process parameters are obtained, to improve the performance of carbon fiber composites to a certain extent...
February 28, 2024: Materials
https://read.qxmd.com/read/38473553/analysis-of-the-effect-of-an-open-hole-on-the-buckling-of-a-compressed-composite-plate
#25
JOURNAL ARTICLE
Pawel Wysmulski
This paper investigates the effect of an open hole on the stability of a compressed laminated composite plate. The study was carried out in two ways: using experimental tests and numerical analysis. As a result of the experiment, the buckling form and path of the plate were recorded. The form of buckling was determined using the ARAMIS non-contact measurement system. The critical load value was determined from the working path using the approximation method. The experimental results were verified by numerical analysis based on the finite element method...
February 27, 2024: Materials
https://read.qxmd.com/read/38473519/electro-mechanical-characterisation-and-damage-monitoring-by-acoustic-emission-of-3d-printed-cb-pla
#26
JOURNAL ARTICLE
Laurane Roumy, Thuy-Quynh Truong-Hoang, Fabienne Touchard, Colin Robert, Francisca Martinez-Hergueta
Even though the influence of the printing direction on the mechanical properties of 3D-printed samples by fused filament fabrication is established in the literature, very little is known about mechanical and electrical coupling. In this study, electrically conductive polylactic acid filled with carbon black particles undergoes monotonic and repeated progressive tensile loading to better understand the influence of the printing direction on the electro-mechanical properties of three-dimensional-printed samples...
February 24, 2024: Materials
https://read.qxmd.com/read/38473516/moisture-effects-on-acoustic-emission-characteristics-and-damage-mechanisms-of-balsa-wood-core-composite-sandwich-under-4-point-bending
#27
JOURNAL ARTICLE
Yuan Wu, Marianne Perrin, Marie-Laetitia Pastor, Pascal Casari, Xiaojing Gong
To contribute to the development of sustainable composites, this work investigates the effects of moisture on the key AE characteristics related to the damage mechanisms of a bio-based balsa wood core sandwich in 4-point bending tests, including cumulative counts, amplitude, peak frequency, and duration. Novel triple dog-bone balsa wood core sandwich specimens with different MC (moisture content) were studied by comparing microscopic observations and a proposed two-step clustering approach in AE analysis. Three MC states, i...
February 24, 2024: Materials
https://read.qxmd.com/read/38473200/the-most-important-metabolic-diseases-in-dairy-cattle-during-the-transition-period
#28
REVIEW
Vincenzo Tufarelli, Nikola Puvača, Dragan Glamočić, Gianluca Pugliese, Maria Antonietta Colonna
This review paper provides an in-depth analysis of three critical metabolic diseases affecting dairy cattle such as subacute ruminal acidosis (SARA), ketosis, and hypocalcemia. SARA represents a disorder of ruminal fermentation that is characterized by extended periods of depressed ruminal pH below 5.5-5.6. In the long term, dairy herds experiencing SARA usually exhibit secondary signs of the disease, such as episodes of laminitis, weight loss and poor body condition despite adequate energy intake, and unexplained abscesses usually 3-6 months after an episode of SARA...
March 6, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38473112/effect-of-exercise-conditioning-on-countering-the-effects-of-obesity-and-insulin-resistance-in-horses-a-review
#29
REVIEW
Shannon Pratt-Phillips
Obesity is an important health concern in horses, along with humans and companion animals. Adipose tissue is an inflammatory organ that alters the insulin-signaling cascade, ultimately causing insulin dysregulation and impaired glucose metabolism. These disruptions can increase the risk of metabolic disease and laminitis in horses and may also impact energy metabolism during exercise. A single bout of exercise, along with chronic exercise conditioning, increases insulin sensitivity and glucose disposal via both contraction- and insulin-mediated glucose uptake pathways...
February 26, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38471580/3d-printed-versus-conventionally-milled-zirconia-for-dental-clinical-applications-trueness-precision-accuracy-biological-and-esthetic-aspects
#30
REVIEW
Mohammed Alghauli, Ahmed Yaseen Alqutaibi, Sebastian Wille, Matthias Kern
OBJECTIVES: This systematic review aimed to compare the clinical outcome, internal gap, trueness, precision, and biocompatibility of 3D-printed (AM) compared to milled (SM) zirconia restorations. DATA SOURCE: A thorough search of Internet databases was conducted up to September 2023. The search retrieved studies compared AM zirconia to SM zirconia restorations regarding clinical outcome, fit, trueness, precision, and biocompatibility. STUDY SELECTION: Of 1736 records, only 59 were screened for eligibility, and 22 records were included in this review...
March 10, 2024: Journal of Dentistry
https://read.qxmd.com/read/38471214/bezoar-in-meckel-s-diverticulum-case-report-and-narrative-review
#31
Guillaume Tcheutchoua Soh, Abdourahmane Ndong, Adja Coumba Diallo, Jacques Noel Tendeng, Mohamed Lamine Diao, Ibrahima Konate
INTRODUCTION: Bezoars are a known cause of complications in Meckel's diverticulum. We present a case in which a bezoar in a Meckel's diverticulum resulted in intestinal obstruction. In addition, we conducted a narrative review to explore the association between Meckel's diverticulum and bezoars. CASE PRESENTATION: We present the case of a 22-year-old patient admitted for bowel obstruction persisting for three days and periumbilical tenderness. Abdominal CT tomography revealed a hyper dense circular structure with a diameter of 2 cm, small bowel distension of 41 mm, and free fluid...
March 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38467601/float-stacked-graphene-pmma-laminate
#32
JOURNAL ARTICLE
Seung-Il Kim, Ji-Yun Moon, Seok-Ki Hyeong, Soheil Ghods, Jin-Su Kim, Jun-Hui Choi, Dong Seop Park, Sukang Bae, Sung Ho Cho, Seoung-Ki Lee, Jae-Hyun Lee
Semi-infinite single-atom-thick graphene is an ideal reinforcing material that can simultaneously improve the mechanical, electrical, and thermal properties of matrix. Here, we present a float-stacking strategy to accurately align the monolayer graphene reinforcement in polymer matrix. We float graphene-poly(methylmethacrylate) (PMMA) membrane (GPM) at the water-air interface, and wind-up layer-by-layer by roller. During the stacking process, the inherent water meniscus continuously induces web tension of the GPM, suppressing wrinkle and folding generation...
March 11, 2024: Nature Communications
https://read.qxmd.com/read/38466184/manipulation-of-the-nuclear-envelope-associated-protein-slap-during-mammalian-brain-development-affects-cortical-lamination-and-exploratory-behavior
#33
JOURNAL ARTICLE
Ivan Mestres, Azra Atabay, Joan-Carles Escolano, Solveig Arndt, Klara Schmidtke, Maximilian Einsiedel, Melina Patsonis, Lizbeth Airais Bolaños-Castro, Maximina Yun, Nadine Bernhardt, Anna Taubenberger, Federico Calegari
Here, we report the first characterization of the effects resulting from the manipulation of Soluble-Lamin Associated Protein (SLAP) expression during mammalian brain development. We found that SLAP localizes to the nuclear envelope and when overexpressed causes changes in nuclear morphology and lengthening of mitosis. SLAP overexpression in apical progenitors of the developing mouse brain altered asymmetric cell division, neurogenic commitment and neuronal migration ultimately resulting in unbalance in the proportion of upper, relative to deeper, neuronal layers...
March 1, 2024: Biology Open
https://read.qxmd.com/read/38465831/e-tattoos-toward-functional-but-imperceptible-interfacing-with-human-skin
#34
REVIEW
Hongbian Li, Philip Tan, Yifan Rao, Sarnab Bhattacharya, Zheliang Wang, Sangjun Kim, Susmita Gangopadhyay, Hongyang Shi, Matija Jankovic, Heeyong Huh, Zhengjie Li, Pukar Maharjan, Jonathan Wells, Hyoyoung Jeong, Yaoyao Jia, Nanshu Lu
The human body continuously emits physiological and psychological information from head to toe. Wearable electronics capable of noninvasively and accurately digitizing this information without compromising user comfort or mobility have the potential to revolutionize telemedicine, mobile health, and both human-machine or human-metaverse interactions. However, state-of-the-art wearable electronics face limitations regarding wearability and functionality due to the mechanical incompatibility between conventional rigid, planar electronics and soft, curvy human skin surfaces...
March 11, 2024: Chemical Reviews
https://read.qxmd.com/read/38464607/radiographic-assessment-of-normal-parameters-of-forelimb-distal-phalanx-in-turkmen-horses
#35
JOURNAL ARTICLE
Keramat Allah Khaledi, Ali Mirshahi, Kamran Sardari, Mohammad Azizzadeh, Samaneh Ghasemi
The Turkmen horse is one of the oldest breeds in the world with unique characteristics in agility, endurance and jump, being publicly acclaimed. Laminitis affects the limbs and decreases athletic performance. Radiographic evaluation is essential to confirm the sinking diagnosis in every breed of a horse suffering from laminitis. Since no information about distal phalanx radiographic measurements in this breed has been reported, the current study was designed and conducted. In the present study, 24 clinically sound registered Turkmen horses of both sexes (15 mares and nine stallions) were selected...
2024: Veterinary Research Forum
https://read.qxmd.com/read/38462947/upregulated-expression-of-lamin-b-receptor-increases-cell-proliferation-and-suppresses-genomic-instability-implications-for-cellular-immortalization
#36
JOURNAL ARTICLE
Atsuki En, Kentaro Takemoto, Yoshimi Yamakami, Kazuhiko Nakabayashi, Michihiko Fujii
Mammalian somatic cells undergo terminal proliferation arrest after a limited number of cell divisions, a phenomenon termed cellular senescence. However, cells acquire the ability to proliferate infinitely (cellular immortalization) through multiple genetic alterations. Inactivation of tumor suppressor genes such as p53, RB and p16 is important for cellular immortalization, although additional molecular alterations are required for cellular immortalization to occur. Here, we aimed to gain insights into these molecular alterations...
March 11, 2024: FEBS Journal
https://read.qxmd.com/read/38461329/quality-assessment-of-malaria-microscopic-diagnosis-at-the-aristide-le-dantec-university-hospital-of-dakar-senegal-in-2020
#37
JOURNAL ARTICLE
Mamane N Garba, Awa B Dème, Khadim Diongue, Younousse Diédhiou, Amadou M Mbaye, NDèye M Dia, N'Dèye A Seck, Daba Zoumarou, Lamine Ndiaye, Mamadou S Yade, Baba Dièye, Aita Sène, Abdoulaye Tine, Mariama Touré, Nogaye Gadiaga, Awa Fall, Bassirou Ngom, Djiby Sow, Aliou Ndiaye, Astou Keita, Mame F Ndiaye, Jules F Gomis, Nana F Diop, Guète Diallo, Ibrahima M Ndiaye, Elhadj M Ba, Omar Bitèye, Cheikh Ndiaye, Fama S D Mbodji, Pape O Ndiaye, Tolla Ndiaye, Amy Gaye, Mouhamad Sy, Yaye D Ndiaye, Mame C Seck, Mouhamadou Ndiaye, Aida S Badiane, Mamadou A Diallo, Daouda Ndiaye
BACKGROUND: Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this context, we assessed the performance of the laboratory by confirming the reliability and the accuracy of results obtained in accordance with the requirements of the ISO 15189 standards. This study aimed to verify the method of microscopic diagnosis of malaria at the LPM, in the Aristide Le Dantec hospital (HALD) in Dakar, Senegal...
March 9, 2024: BMC Research Notes
https://read.qxmd.com/read/38460875/exploring-the-impact-of-high-energy-diets-on-cattle-insights-into-subacute-rumen-acidosis-insulin-resistance-and-hoof-health
#38
JOURNAL ARTICLE
Rodrigo L A Palhano, Ronaldo A Martins, Guilherme S Lemos, Rafael R Faleiros, Leandro A da Fonseca, Leonardo L Gorza, Carlos E B Lopes, Rodrigo M Meneses, Antônio U de Carvalho, Elias J F Filho, Tiago F Moreira
Cattle lameness remains a significant concern, causing economic losses and compromising animal welfare. Claw horn lesions have been identified as a major cause of lameness in dairy cows but its correlation with high-energy diet and ruminal acidosis remains unclear. Hence, the primary objective of this study was to assess the effects of a high starch and a conventional diet on the rumen environment, acute phase proteins, and metabolic alterations, with a particular focus on insulin resistance and the consequent implications for the histology of the hooves in Holstein steers...
March 7, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38460772/a-strategy-to-optimize-precompression-pressure-for-tablet-manufacturing-based-on-in-die-elastic-recovery
#39
JOURNAL ARTICLE
Gerrit Vreeman, Changquan Calvin Sun
A precompression pressure optimization strategy using in-die elastic recovery was developed to effectively address tablet lamination caused by air entrapment. This strategy involves exacerbating the air entrapment issue using high tableting speeds and main compaction pressures and collecting in-die elastic recovery data as a function of precompression pressure. The optimized precompression pressure, which corresponds to the minimum elastic recovery, is most effective at eliminating air from the powder bed prior to the main compression...
March 7, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38460381/polypyrrole-pre-intercalation-engineering-induced-nh-4-removal-in-tunnel-ammonium-vanadate-toward-high-performance-zinc-ion-batteries
#40
JOURNAL ARTICLE
Yangyang Gong, Pengtao Zhang, Shuang Fan, Minghui Cai, Jiangtao Hu, Zhaoyan Luo, Hongwei Mi, Xiantao Jiang, Qianling Zhang, Xiangzhong Ren
Ammonium vanadate with stable bi-layered structure and superior mass-specific capacity have emerged as competitive cathode materials for aqueous rechargeable zinc-ion batteries (AZIBs). Nevertheless, fragile NH…O bonds and too strong electrostatic interaction by virtue of excessive NH4 + will lead to sluggish Zn2+ ion mobility, further largely affects the electro-chemical performance of ammonium vanadate in AZIBs. The present work incorporates polypyrrole (PPy) to partially replace NH4 + in NH4 V4 O10 (NVO), resulting in the significantly enlarged interlayers (from 10...
March 6, 2024: Journal of Colloid and Interface Science
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