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https://www.readbyqxmd.com/read/28635493/the-structure-of-lamin-filaments-in-somatic-cells-as-revealed-by-cryo-electron-tomography
#1
Y Turgay, O Medalia
Metazoan nuclei are equipped with nuclear lamina - a thin layer of intermediate filaments (IFs) mostly built of nuclear lamins facing the inner nuclear membrane (INM). The nuclear lamina serves as an interaction hub for INM-proteins, soluble nuclear factors and DNA. It confers structural and mechanical stability to the nucleus, transduces mechanical forces and biochemical signals across the nuclear envelope (NE) and regulates the organization of chromatin. By utilizing cryo-electron tomography (cryo-ET), we recently provided an unprecedented view into the 3D organization of lamin filaments within the lamina meshwork in mammalian somatic cells...
June 21, 2017: Nucleus
https://www.readbyqxmd.com/read/28632157/development-of-a-novel-transparent-flexible-capacitive-micromachined-ultrasonic-transducer
#2
Da-Chen Pang, Cheng-Min Chang
This paper presents the world's first transparent flexible capacitive micromachined ultrasonic transducer (CMUT) that was fabricated through a roll-lamination technique. This polymer-based CMUT has advantages of transparency, flexibility, and non-contacting detection which provide unique functions in display panel applications. Comprising an indium tin oxide-polyethylene terephthalate (ITO-PET) substrate, SU-8 sidewall and vibrating membranes, and silver nanowire transparent electrode, the transducer has visible-light transmittance exceeding 80% and can operate on curved surfaces with a 40 mm radius of curvature...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28632130/the-laminar-organization-of-the-drosophila-ellipsoid-body-is-semaphorin-dependent-and-prevents-the-formation-of-ectopic-synaptic-connections
#3
Xiaojun Xie, Masashi Tabuchi, Matthew P Brown, Sarah P Mitchell, Mark N Wu, Alex L Kolodkin
The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function remain unknown. We show here that the EB is sequentially innervated by small-field and large-field neurons, and that early-developing EB neurons play an important regulatory role in EB laminae formation...
June 20, 2017: ELife
https://www.readbyqxmd.com/read/28631480/fully-transparent-quantum-dot-light-emitting-diode-with-a-laminated-top-graphene-anode
#4
Li Yao, Xin Fang, Wei Gu, Wenhao Zhai, Yi Wan, Xixi Xie, Wanjin Xu, Xiaodong Pi, Guangzhao Ran, Guogang Qin
A new method to employ graphene as top electrode was introduced, and based on that, fully transparent quantum dot light emitting diodes (T-QLEDs) were sucessfully fabribated through a lamination process. We adopted the widely used wet transfer method to transfer bilayer graphene (BG) on polydimethylsiloxane/polyethylene terephthalate (PDMS/PET) substrate. The sheet resistance of graphene reduced to ~540 Ω/□ through transferring BG for 3 times on the PDMS/PET. The T-QLED has an inverted device structure of glass/Indium tin oxide (ITO)/ZnO nanoparticles (NPs)/(CdSSe/ZnS quantum dots (QDs))/ 1,1-bis[(di-4-tolylamino)phenyl] cyclohexane (TAPC)/MoO3/ graphene/PDMS/PET...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28627136/enhancer-of-rudimentary-homologue-interacts-with-scaffold-attachment-factor-b-at-the-nuclear-matrix-to-regulate-sr-protein-phosphorylation
#5
Sotiria Drakouli, Aggeliki Lyberopoulou, Maria Papathanassiou, Ilias Mylonis, Eleni Georgatsou
Scaffold Attachment Factor B1 (SAFB1) is an integral component of the nuclear matrix of vertebrate cells.It binds to DNA on scaffold/matrix attachment region (S/MAR) elements, to RNA, and to a multitude of different proteins, affecting, as has been extensively substantiated, basic cellular activities such as transcription, splicing and DNA damage repair (DDR). In this study, we show that Enhancer of Rudimentary Homologue (ERH) is a new molecular partner of SAFB1 and its 70% homologous paralogue, Scaffold Attachment Factor B2 (SAFB2)...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28623920/ketamine-induced-apoptosis-in-the-mouse-cerebral-cortex-follows-similar-characteristic-of-physiological-apoptosis-and-can-be-regulated-by-neuronal-activity
#6
Qi Wang, Feng-Yan Shen, Rong Zou, Jing-Jing Zheng, Xiang Yu, Ying-Wei Wang
The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is important to determine whether anesthesia-induced apoptosis targets the same cell population as physiological apoptosis or different cell types altogether. To provide an adequate plane of surgery, ketamine was co-administered with dexmedetomidine. The apoptotic neurons in the mouse primary somatosensory cortex (S1) were quantitated by immunohistochemistry...
June 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28621919/insights-on-tuning-the-nanostructure-of-rgo-laminate-membranes-for-low-pressure-osmosis-process
#7
Qiuze Wang, Cyril Aubry, Yaxin Chen, Huaihe Song, Linda Zou
In this research, rGO laminates were prepared by a controlled partial reduction step, aimed to avoid aggregation and tune the interlayer spacing (d) between the rGO layers. The mild reducing agent vitamin C (L-AA) and cross-linker polycarboxilic acids were used to improve the stability of the assembled rGO laminate membranes. AFM was used for the first time to further investigate the statistical size distribution of spacing between rGO layers. Topographical images of the edges of the rGO layers were obtained with an AFM instrument, interlayer spacing profiles were extracted and then the data was plotted and fitted with Gaussian curves...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28620549/lamination-of-microfibrous-plga-fabric-by-electrospinning-a-layer-of-collagen-hydroxyapatite-composite-nanofibers-for-bone-tissue-engineering
#8
Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung, Inn-Kyu Kang
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28619888/response-to-comment-on-xist-recruits-the-x-chromosome-to-the-nuclear-lamina-to-enable-chromosome-wide-silencing
#9
Chun-Kan Chen, Amy Chow, Mason Lai, Mitchell Guttman
Wang et al question whether Lamin B receptor is required for Xist-mediated silencing because they claim that our cells contain an inversion rather than a deletion. We present evidence that these cells contain a proper deletion and that the confusion is caused by DNA probes used in the experiment. Accordingly, the points raised have no effect on the conclusions in our paper.
June 16, 2017: Science
https://www.readbyqxmd.com/read/28619887/comment-on-xist-recruits-the-x-chromosome-to-the-nuclear-lamina-to-enable-chromosome-wide-silencing
#10
Chen-Yu Wang, John E Froberg, Roy Blum, Yesu Jeon, Jeannie T Lee
Chen et al (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported genotypes of mutants are not supported by the sequencing data. These inconsistencies preclude assessment of the role of LBR in Xist spreading.
June 16, 2017: Science
https://www.readbyqxmd.com/read/28617352/equivalent-circuit-model-of-low-frequency-magnetoelectric-effect-in-disk-type-terfenol-d-pzt-laminate-composites-considering-a-new-interface-coupling-factor
#11
Guofeng Lou, Xinjie Yu, Shihua Lu
This paper describes the modeling of magnetoelectric (ME) effects for disk-type Terfenol-D (Tb0.3Dy0.7Fe1.92)/PZT (Pb(Zr,Ti)O₃) laminate composite at low frequency by combining the advantages of the static elastic model and the equivalent circuit model, aiming at providing a guidance for the design and fabrication of the sensors based on magnetoelectric laminate composite. Considering that the strains of the magnetostrictive and piezoelectric layers are not equal in actual operating due to the epoxy resin adhesive bonding condition, the magnetostrictive and piezoelectric layers were first modeled through the equation of motion separately, and then coupled together with a new interface coupling factor kc, which physically reflects the strain transfer between the phases...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28615691/human-myogenic-reserve-cells-are-quiescent-stem-cells-that-contribute-to-muscle-regeneration-after-intramuscular-transplantation-in-immunodeficient-mice
#12
Thomas Laumonier, Flavien Bermont, Pierre Hoffmeyer, Vincent Kindler, Jacques Menetrey
Satellite cells, localized within muscles in vivo, are Pax7(+) muscle stem cells supporting skeletal muscle growth and regeneration. Unfortunately, their amplification in vitro, required for their therapeutic use, is associated with reduced regenerative potential. In the present study, we investigated if human myogenic reserve cells (MRC) obtained in vitro, represented a reliable cell source for muscle repair. For this purpose, primary human myoblasts were freshly isolated and expanded. After 2 days of differentiation, 62 ± 2...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28612607/stereoselective-cyclopropanation-to-homoquinones-from-phenacyl-carbenes-obtained-through-quinone-electrogenerated-bases
#13
Kaouthar Hamrouni, Fructuoso Barba, Mohamed Lamine Benkhoud, Belen Batanero
A series of new (E) and (Z)-benzoyl-homoquinones have been prepared in good yield by the parent quinone-electrogenerated base (EGB) in the presence of α-bromoacetophenones or α-bromopropiophenone. The EGB, obtained when electrolysis of p-benzoquinone, or 1,4-naphthoquinone, is carried out at the reduction potential of their first voltammetric peak, conducted to electrogenerated phenacyl carbenes after halide evolution on the first obtained bromo-enolates. The stereoselectivity of the [2 + 2]cycloaddition of the carbene to the quinoid substrate is highly dependent on the electrode nature...
June 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28610487/establishment-of-novel-meniscal-scaffold-structures-using-polyglycolic-and-poly-l-lactic-acids
#14
Tomohiko Murakami, Shuhei Otsuki, Kosuke Nakagawa, Yoshinori Okamoto, Tae Inoue, Yuki Sakamoto, Hideki Sato, Masashi Neo
The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28607399/rim1-2-in-retinal-ganglion-cells-are-required-for-the-refinement-of-ipsilateral-axons-and-eye-specific-segregation
#15
Ahlem Assali, Corentin Le Magueresse, Mohamed Bennis, Xavier Nicol, Patricia Gaspar, Alexandra Rebsam
Neural activity is crucial for the refinement of neuronal connections during development, but the contribution of synaptic release mechanisms is not known. In the mammalian retina, spontaneous neural activity controls the refinement of retinal projections to the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) to form appropriate topographic and eye-specific maps. To evaluate the role of synaptic release, the rab-interacting molecules (RIMs), a family of active zone proteins that play a central role in calcium-triggered release, were conditionally ablated in a subset of retinal ganglion cells (RGCs)...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603834/abstracts-of-the-maghreb-medical-congress-2015
#16
A Dahmeni, M Bouchekoua, D Aloui, S Trabelsi, S Khaled, S Gara, B Herbegue, A Chetoui, S Sellami, I Slama, S Antit, E Boussabah, M Thameur, L Zakhama, S Benyoussef, F Guemira, N Bellil, D Gargouri, N Masmoudi, H Elloumi, N Bibani, D Trad, J Kharrat, I Tounsi, N Fakhfakh, A Kallel, N Hadj Salah, S Belhadj, S Ladab, K Kallell, I Ayadi, S Frikha, M Messaoud, S Belhaj, H Triki, K Kallel, S BenHamida, I Ghribi, A Belkhamsa, M Ben Hamida, I Cheikh, B Hamdi, S Maazaoui, A Berraies, H Sakly, H Blibech, J Ammar, A Hamzaoui, S Belaazri, F Lamine, A Baidada, A Kharbach, A Mensi, A Ben Mohammed, S Khedher, L Mouelhi, F Houissa, T Najjar, R BenJemàa, A Oukaa-Kchaou, I Ben Mefteh, A Ayachi, I Morjène, H Trabelsi, M Mourali, H Maghrebi, M Barka, A Haddad, A Jlassi, A Makni, A Daghfous, W Rebai, F Fteriche, F Chebbi, F Ksantini, A Ammous, M Jouini, M J Kacem, Z Ben Safta, M Cherif, H Zaafouri, A Bouhafa, A Ben Maamer, M Ben Khelifa, O Daboussi, K El Jeri, Y Said, M Salem, R Dabbech, M Hadidane, A Triki, H Henchiri, M Driss, J Ben Hassouna, M Hechiche, T Dhieb, K Rahal, J Lamghari, D Khaiz, Y Ghaddou, P Avala, K El Hattabi, F Z Bensardi, M R Lefriyekh, A Fadil, N O Zerouali, I Benahmed, M Karrou, K Benjaout, R Marouf, I Alloubi, L Achouri, M Slimene, B Laamouri, M Jendoubi, L Satouri, F Ghoul, H Reziga, M Malek, M K Makni, A Baba, A M Derbel, L Sellami, M Zili, R Khelifa, I Benahmed, K Benjaout, I Alloubi, R Maarouf, A Youssef, Bnr Amdouni, M Gharrad, M Saadaoui, M Mbarki, H Rezigua, C Shimi, J Semlani, S Amhajer, H Ghouda, Z Imane, M Gaouzi, Y Kriouile, M Attia, A Ben Amor, S Banneni, K Dimassi, A Triki, M F Gara, B Amdouni, L Bennasser, H Magherbi, I Jallouli, S Harabi, S Kbeili, M Derbel, H Gassara, D Louati, K Chaabene
No abstract text is available yet for this article.
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28601421/impact-of-the-introduction-of-pneumococcal-conjugate-vaccination-on-pneumonia-in-the-gambia-population-based-surveillance-and-case-control-studies
#17
Grant A Mackenzie, Philip C Hill, Shah M Sahito, David J Jeffries, Ilias Hossain, Christian Bottomley, Uchendu Uchendu, David Ameh, Malick Ndiaye, Chidebereh D Osuorah, Oyedeji Adeyemi, Jayani Pathirana, Yekini Olatunji, Bade Abatan, Ebirim Ahameefula, Bilquees S Muhammad, Augustin E Fombah, Debasish Saha, Roslyn Mackenzie, Ian Plumb, Aliu Akano, Bernard Ebruke, Readon C Ideh, Bankole Kuti, Peter Githua, Emmanuel Olutunde, Ogochukwu Ofordile, Edward Green, Effua Usuf, Henry Badji, Usman N A Ikumapayi, Ahmad Manjang, Rasheed Salaudeen, E David Nsekpong, Sheikh Jarju, Martin Antonio, Sana Sambou, Lamin Ceesay, Yamundow Lowe-Jallow, Dawda Sowe, Momodou Jasseh, Kim Mulholland, Maria Knoll, Orin S Levine, Stephen R Howie, Richard A Adegbola, Brian M Greenwood, Tumani Corrah
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) are used in many low-income countries but their impact on the incidence of pneumonia is unclear. The Gambia introduced PCV7 in August, 2009, and PCV13 in May, 2011. We aimed to measure the impact of the introduction of these vaccines on pneumonia incidence. METHODS: We did population-based surveillance and case-control studies. The primary endpoint was WHO-defined radiological pneumonia with pulmonary consolidation...
June 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28600460/standard-operating-procedures-improve-acute-neurologic-care-in-a-sub-saharan-african-setting
#18
Lamin E S Jaiteh, Stefan A Helwig, Abubacarr Jagne, Andreas Ragoschke-Schumm, Catherine Sarr, Silke Walter, Martin Lesmeister, Matthias Manitz, Sebastian Blaß, Sarah Weis, Verena Schlund, Neneh Bah, Jil Kauffmann, Mathias Fousse, Sabina Kangankan, Asmell Ramos Cabrera, Kai Kronfeld, Christian Ruckes, Yang Liu, Ousman Nyan, Klaus Fassbender
OBJECTIVE: Quality of neurologic emergency management in an under-resourced country may be improved by standard operating procedures (SOPs). METHODS: Neurologic SOPs were implemented in a large urban (Banjul) and a small rural (Brikama) hospital in the Gambia. As quality indicators of neurologic emergency management, performance of key procedures was assessed at baseline and in the first and second implementation years. RESULTS: At Banjul, 100 patients of the first-year intervention group exhibited higher rates of general procedures of emergency management than 105 control patients, such as neurologic examination (99...
June 9, 2017: Neurology
https://www.readbyqxmd.com/read/28598152/continuous-ink-multiplexed-pen-plotter-approach-for-low-cost-high-throughput-fabrication-of-paper-based-microfluidics
#19
Reza Amin, Fariba Ghaderinezhad, Lu Li, Eric Lepowsky, Bekir Yenilmez, Stephanie Knowlton, Savas Tasoglu
There is an unmet need for high-throughput fabrication techniques for paper-based microanalytical devices, especially in limited resource areas. Fabrication of these devices requires precise and repeatable deposition of hydrophobic materials in a defined pattern to delineate the hydrophilic reaction zones. In this study, we demonstrated a cost- and time-effective method for high-throughput, easily accessible fabrication of paper-based microfluidics using a desktop pen plotter integrated with a custom-designed multipen holder...
June 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28597663/enhancement-of-light-absorption-in-photovoltaic-devices-using-textured-polydimethylsiloxane-stickers
#20
Inchan Hwang, Deokjae Choi, Sojeong Lee, Ji Hoon Seo, Ka-Hyun Kim, Ilsun Yoon, Kwanyong Seo
We designed and fabricated a random-size inverted-pyramid-structured polydimethylsiloxane (RSIPS-PDMS) sticker to enhance the light absorption of solar cells and thus increase their efficiency. The fabricated sticker was laminated onto bare glass and crystalline silicon (c-Si) surfaces; consequently, low solar-weighted reflectance values were obtained for these surfaces (6.88 and 17.2%, respectively). In addition, we found that incident light was refracted at the PDMS-air interface of each RSIPS, which redirected the incident power and significantly increased the optical path length in the RSIPS-PDMS sticker which was 14...
June 16, 2017: ACS Applied Materials & Interfaces
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