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https://www.readbyqxmd.com/read/28737748/inflammation-free-gas-permeable-lightweight-stretchable-on-skin-electronics-with-nanomeshes
#1
Akihito Miyamoto, Sungwon Lee, Nawalage Florence Cooray, Sunghoon Lee, Mami Mori, Naoji Matsuhisa, Hanbit Jin, Leona Yoda, Tomoyuki Yokota, Akira Itoh, Masaki Sekino, Hiroshi Kawasaki, Tamotsu Ebihara, Masayuki Amagai, Takao Someya
Thin-film electronic devices can be integrated with skin for health monitoring and/or for interfacing with machines. Minimal invasiveness is highly desirable when applying wearable electronics directly onto human skin. However, manufacturing such on-skin electronics on planar substrates results in limited gas permeability. Therefore, it is necessary to systematically investigate their long-term physiological and psychological effects. As a demonstration of substrate-free electronics, here we show the successful fabrication of inflammation-free, highly gas-permeable, ultrathin, lightweight and stretchable sensors that can be directly laminated onto human skin for long periods of time, realized with a conductive nanomesh structure...
July 17, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28737169/actomyosin-drives-cancer-cell-nuclear-dysmorphia-and-threatens-genome-stability
#2
Tohru Takaki, Marco Montagner, Murielle P Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J Boulton, Erik Sahai, Mark Petronczki
Altered nuclear shape is a defining feature of cancer cells. The mechanisms underlying nuclear dysmorphia in cancer remain poorly understood. Here we identify PPP1R12A and PPP1CB, two subunits of the myosin phosphatase complex that antagonizes actomyosin contractility, as proteins safeguarding nuclear integrity. Loss of PPP1R12A or PPP1CB causes nuclear fragmentation, nuclear envelope rupture, nuclear compartment breakdown and genome instability. Pharmacological or genetic inhibition of actomyosin contractility restores nuclear architecture and genome integrity in cells lacking PPP1R12A or PPP1CB...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28735035/the-lamin-code
#3
Nadir M Maraldi
Unicellular eukaryotes and metazoa present a nuclear envelope (NE) and metazoa express in it one or more lamins that give rise to the nuclear lamina. The expression of different types of lamins is related to the complexity of the organism and the expression of type-A lamins is related to the initial steps of tissue-specific cell differentiation. Several posttranslational modifications characterize the expression of lamin A in the course of cell differentiation, and the alteration of this expression pattern leads to impressive phenotypic diseases that are collectively referred to as laminopathies...
July 19, 2017: Bio Systems
https://www.readbyqxmd.com/read/28732934/enhanced-crack-suppression-ability-of-hybrid-glass-fiber-reinforced-laminated-composites-fabricated-using-gnp-epoxy-system-by-optimized-udm-parameters
#4
Pannalal Choudhury, Sudipta Halder, Nazrul Islam Khan, Jialai Wang, Krishna Murari Pandey
In this work, GFRPs with layer-up [+22/-22/90n]s were prepared and hybridized with 0.5wt% of GNPs to introduce in-situ crack suppression ability. Optimization of the processing parameters of ultrasonic dual mode mixing (UDM) process was adopted to disperse GNPs uniformly in the epoxy system and place them evenly at the interfacial zones of GFRPs. Test results show that 102% and 153% enhancement in tensile strength and Young's modulus has been achieved by the proposed method. Low stirring speed and low pulse-off time show significant effect on properties of the GFRPs...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28730362/removal-of-cr-vi-from-aqueous-solution-using-electrosynthesized-4-amino-3-hydroxynaphthalene-1-sulfonic-acid-doped-polypyrrole-as-adsorbent
#5
Mohamed Lamine Sall, Abdou Karim Diagne Diaw, Diariatou Gningue-Sall, Alexandre Chevillot-Biraud, Nihal Oturan, Mehmet Ali Oturan, Jean-Jacques Aaron
Polypyrrole (PPy) conducting films, doped with 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA), were electrosynthesized by anodic oxidation of pyrrole on Pt and steel electrodes in aqueous medium (0.01 M AHNSA +0.007 M NaOH, using cyclic voltammetry (CV), and their electrochemical properties were studied. Fourier-transform infrared (FT-IR) spectroscopy confirmed the formation of AHNSA-PPy films. Their morphology was characterized by scanning electron microscopy (SEM), and their optical properties, including UV-VIS absorption and fluorescence spectra, were also investigated...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28729432/tropomodulin1-controls-erythroblast-enucleation-via-regulation-of-f-actin-in-the-enucleosome
#6
Roberta B Nowak, Julien Papoin, David S Gokhin, Carla Casu, Stefano Rivella, Jeffrey M Lipton, Lionel Blanc, Velia M Fowler
Biogenesis of mammalian red blood cells requires nuclear expulsion by orthochromatic erythoblasts late in terminal differentiation (enucleation), but the mechanism is largely unexplained. Here, we employed high resolution confocal microscopy to analyze nuclear morphology and F-actin rearrangements during the initiation, progression and completion of mouse and human erythroblast enucleation in vivo Mouse erythroblast nuclei acquire a dumbbell-shaped morphology during enucleation, while human bone marrow erythroblast nuclei unexpectedly retain their spherical morphology...
July 20, 2017: Blood
https://www.readbyqxmd.com/read/28727493/sibilant-production-in-hebrew-speaking-adults-apical-versus-laminal
#7
Michal Icht, Boaz M Ben-David
The Hebrew IPA charts describe the sibilants /s, z/ as 'alveolar fricatives', where the place of articulation on the palate is the alveolar ridge. The point of constriction on the tongue is not defined - apical (tip) or laminal (blade). Usually, speech and language pathologists (SLPs) use the apical placement in Hebrew articulation therapy. Some researchers and SLPs suggested that acceptable /s, z/ could be also produced with the laminal placement (i.e. the tip of the tongue approximating the lower incisors)...
July 20, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28727072/the-equine-glucose-dependent-insulinotropic-polypeptide-receptor-a-potential-therapeutic-target-for-insulin-dysregulation
#8
M H Kheder, M N Sillence, L M Bryant, M A de Laat
Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent insulinotropic polypeptide (GIP) biology has led to the suggestion that inhibiting its action may attenuate obesity in several species. In horses, antagonism of GIP may also reduce hyperinsulinemia, which leads to insulin-associated laminitis, a painful comorbidity unique to this species. However, little is known about GIP in horses. The aims of this study were to examine the tissue distribution of equine GIP receptors (eGIPR), to determine whether eGIPR can be blocked using a GIP antagonist not tested previously in horses, and to establish whether there is any association between GIP concentrations and body mass in this species...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726542/generation-and-functional-characterization-of-anti-human-and-anti-mouse-il-36r-antagonist-monoclonal-antibodies
#9
Rajkumar Ganesan, Ernest L Raymond, Detlev Mennerich, Joseph R Woska, Gary Caviness, Christine Grimaldi, Jennifer Ahlberg, Rocio Perez, Simon Roberts, Danlin Yang, Kavita Jerath, Kristopher Truncali, Lee Frego, Eliud Sepulveda, Priyanka Gupta, Su-Ellen Brown, Michael D Howell, Keith A Canada, Rachel Kroe-Barrett, Jay S Fine, Sanjaya Singh, M Lamine Mbow
Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the IL1R family that is involved in inflammatory responses triggered in skin and other epithelial tissues. Accumulating evidence suggests that IL-36R signaling may play a role in the pathogenesis of psoriasis. Therapeutic intervention of IL-36R signaling offers an innovative treatment paradigm for targeting epithelial cell-mediated inflammatory diseases such as the life-threatening psoriasis variant called generalized pustular psoriasis (GPP)...
July 20, 2017: MAbs
https://www.readbyqxmd.com/read/28725006/diffusive-displacive-deformations-and-local-phase-transformation-govern-the-mechanics-of-layered-crystals-the-case-study-of-tobermorite
#10
Lei Tao, Rouzbeh Shahsavari
Understanding the deformation mechanisms underlying the mechanical behavior of materials is the key to fundamental and engineering advances in materials' performance. Herein, we focus on crystalline calcium-silicate-hydrates (C-S-H) as a model system with applications in cementitious materials, bone-tissue engineering, drug delivery and refractory materials, and use molecular dynamics simulation to investigate its loading geometry dependent mechanical properties. By comparing various conventional (e.g. shear, compression and tension) and nano-indentation loading geometries, our findings demonstrate that the former loading leads to size-independent mechanical properties while the latter results in size-dependent mechanical properties at the nanometer scales...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28721407/3d-printed-reversible-shape-changing-soft-actuators-assisted-by-liquid-crystal-elastomers
#11
Chao Yuan, Devin J Roach, Conner K Dunn, Quanyi Mu, Xiao Kuang, Christopher M Yakacki, T J Wang, Kai Yu, H Jerry Qi
In this work, we advance printed active composites by combining 3D printing, printed electronics, and liquid crystal elastomers (LCEs) to achieve soft actuators with free-standing two-way shape changing behaviors. Incorporated LCE strips are activated by Joule heating produced by printed conductive wires, while uniaxial deformation of the LCE strip is utilized as a driving force to achieve bending in the printed composite. The bending behavior of laminated hinges is first characterized in order to obtain a precise control of actuation, which is then exploited to actuate four demonstrative designs: a morphing airplane, a miura-ori structure, a cubic box, and a soft crawler...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28720531/molecular-cloning-and-characterization-of-the-genes-encoding-the-proteins-of-zika-virus
#12
Wangheng Hou, Ruth Cruz-Cosme, Najealicka Armstrong, Lilian Akello Obwolo, Fayuan Wen, Wenhui Hu, Min-Hua Luo, Qiyi Tang
Zika virus (ZIKV) encodes a precursor protein (also called polyprotein) of about 3424 amino acids that is processed by proteases to generate 10 mature proteins and a small peptide. In the present study, we characterized the chemical features, suborganelle distribution and potential function of each protein using Flag-tagged protein expression system. Western blot analysis revealed the molecular weight of the proteins and the polymerization of E, NS1, and NS3 proteins. In addition, we performed multi-labeled fluorescent immunocytochemistry and subcellular fractionation to determine the subcellular localization of these proteins in host cells...
July 15, 2017: Gene
https://www.readbyqxmd.com/read/28719739/graphene-electronic-tattoo-sensors
#13
Shideh Kabiri Ameri, Rebecca Ho, Hongwoo Jang, Li Tao, Youhua Wang, Liu Wang, David M Schnyer, Deji Akinwande, Nanshu Lu
Tattoo-like epidermal sensors are an emerging class of truly wearable electronics owing to their thinness and softness. While most of them are based on thin metal films, silicon membrane, or nanoparticle-based printable inks, we report a sub-micron thick, multimodal electronic tattoo sensors that are made of graphene. The graphene electronic tattoo (GET) is designed with filamentary serpentines and fabricated by a cost- and time-effective "wet transfer, dry patterning" method. It has a total thickness of 463 ± 30 nm, an optical transparency of ~85%, and a stretchability of more than 40%...
July 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28718167/are-computer-numerical-control-cnc-manufactured-patient-specific-metal-templates-available-for-posterior-thoracic-pedicle-screw-insertion-feasibility-and-accuracy-evaluation
#14
Xiangxue Kong, Lei Tang, Qiang Ye, Wenhua Huang, Jianyi Li
PURPOSE: Accurate and safe posterior thoracic pedicle insertion (PTPI) remains a challenge. Patient-specific drill templates (PDTs) created by rapid prototyping (RP) can assist in posterior thoracic pedicle insertion, but pose biocompatibility risks. The aims of this study were to develop alternative PDTs with computer numerical control (CNC) and assess their feasibility and accuracy in assisting PTPI. METHODS: Preoperative CT images of 31 cadaveric thoracic vertebras were obtained and then the optimal pedicle screw trajectories were planned...
July 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28714269/impermeable-robust-hydrogels-via-hybrid-lamination
#15
German A Parada, Hyunwoo Yuk, Xinyue Liu, Alex J Hsieh, Xuanhe Zhao
Hydrogels have been proposed for sensing, drug delivery, and soft robotics applications, yet most of these materials suffer from low mechanical robustness and high permeability to small molecules, limiting their widespread use. This study reports a general strategy and versatile method to fabricate robust, highly stretchable, and impermeable hydrogel laminates via hybrid lamination of an elastomer layer bonded between hydrogel layers. By controlling the layers' composition and thickness, it is possible to tune the stiffness of the impermeable hydrogels without sacrificing the stretchability...
July 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28712764/nucleocytoplasmic-transport-in-cells-with-progerin-induced-defective-nuclear-lamina
#16
Gianmarco Ferri, Barbara Storti, Ranieri Bizzarri
Recent data indicate that nuclear lamina (NL) plays a relevant role in many fundamental cellular functions. The peculiar role of NL in cells is dramatically demonstrated by the Hutchinson-Gilford progeria syndrome (HGPS), an inherited laminopathy that causes premature, rapid aging shortly after birth. In HGPS, a mutant form of Lamin A (progeria) leads to a dysmorphic NL structure, but how this perturbation is transduced into cellular changes is still largely unknown. Owing to the close structural relationship between NL and the Nuclear Pore Complex (NPC), in this work we test whether HGPS affects passive and active nucleo-cytoplasmic shuttling of cargoes by means of an established model based of fluorescence recovery after photobleaching...
June 28, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28708381/microfabrication-of-monolithic-microfluidic-platforms-using-low-temperature-co-fired-ceramics-suitable-for-fluorescence-imaging
#17
Pedro Couceiro, Julián Alonso-Chamarro
In this work, the influence of laser ablation and lamination parameters in the fabrication of embedded microstructures using Low Temperature Co-Fired Ceramics, have been studied. First, the influence of laser ablation parameters in the dimensions of fabricated microchannels in Low Temperature Co-Fired Ceramics substrates was characterized and strategies for tailoring the microchannels aspect ratios are described. The influence of lamination conditions on the fabrication of monolithically embedded microstructures is presented...
July 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28703351/a-comparative-study-between-responses-of-isolated-bovine-and-equine-digital-arteries-to-vasoactive-mediators
#18
C Zizzadoro, M Caruso, S Punzi, G Crescenzo, F Zongoli, C Belloli
Hemodynamic perturbations, partly resulting from abnormal vasoconstriction of digital vessels, have been implicated in the pathogenesis of bovine and equine laminitis. This study compared the responsiveness of isolated bovine (BDA) and equine (EDA) digital arteries to pharmacological agents that stimulate receptor systems involved in the regulation of normal vessel tone. The role of the endothelium and the short- and longer-term effects of an experimentally induced endothelial damage were also evaluated. Species-related differences were found in the vessel reactivity to all of the receptor agonists tested...
July 13, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28696268/personalizing-risk-stratification-for-sudden-death-in-dilated-cardiomyopathy-the-past-present-and-future
#19
REVIEW
Brian P Halliday, John G F Cleland, Jeffrey J Goldberger, Sanjay K Prasad
Results from the DANISH Study (Danish Study to Assess the Efficacy of ICDs in Patients With Non-Ischemic Systolic Heat Failure on Mortality) suggest that for many patients with dilated cardiomyopathy (DCM), implantable cardioverter-defibrillators do not increase longevity. Accurate identification of patients who are more likely to die of an arrhythmia and less likely to die of other causes is required to ensure improvement in outcomes and wise use of resources. Until now, left ventricular ejection fraction has been used as a key criterion for selecting patients with DCM for an implantable cardioverter-defibrillator for primary prevention purposes...
July 11, 2017: Circulation
https://www.readbyqxmd.com/read/28691891/incidence-of-oxa-23-and-oxa-58-carbapenemases-coexpressed-in-clinical-isolates-of-acinetobacter-baumannii-in-tunisia
#20
Najla Mathlouthi, Yomna Ben Lamine, Rania Somai, Sophia Bouhalila-Besbes, Sofiane Bakour, Jean-Marc Rolain, Chedly Chouchani
Acinetobacter baumannii is an important opportunistic and multidrug-resistant pathogen responsible for nosocomial infections in health facilities. The aim of this study was to characterize the molecular mechanisms of carbapenem resistance in A. baumannii isolates isolated from Mohamed Kassab Orthopedic Institute in Tunis, Tunisia. Twenty-five imipenem-resistant A. baumannii clinical isolates collected between 2013 and 2016 were identified using API 20NE and were confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS)...
July 10, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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