keyword
https://read.qxmd.com/read/38493209/protein-kinase-c-activity-modulates-nuclear-lamin-a-c-dynamics-in-hela-cells
#1
JOURNAL ARTICLE
Chase C Wesley, Dallin V North, Daniel L Levy
The nuclear lamina serves important functions in the nucleus, providing structural support to the nuclear envelope and contributing to chromatin organization. The primary proteins that constitute the lamina are nuclear lamins whose functions are impacted by post-translational modifications, including phosphorylation by protein kinase C (PKC). While PKC-mediated lamin phosphorylation is important for nuclear envelope breakdown during mitosis, less is known about interphase roles for PKC in regulating nuclear structure...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38492352/damage-recovery-in-composite-laminates-through-deep-learning-from-acoustic-scattering-of-guided-waves
#2
JOURNAL ARTICLE
Bernardo Feijó Junqueira, Ricardo Leiderman, Daniel Alves Castello
We propose an innovative deep learning (DL) regression strategy combined with guided wave modes to address inverse acoustic scattering problems effectively. This approach allows for accurate recovery of heterogeneous defect fields at the interfaces of composite laminates. The neural network (NN) model's training process employs stochastic Gaussian fields as output, which are linked to the interfacial defect fields of the physical problem. Our method assumes prior knowledge of the material geometrical properties of the constituent layers...
March 15, 2024: Ultrasonics
https://read.qxmd.com/read/38491816/advancing-access-to-care-an-assessment-of-the-prehospital-system-in-senegal
#3
JOURNAL ARTICLE
Kamil Michalski, Moustapha Diedhiou, Matin Kerachian, Jeremy Grushka, Jacques Noel Tendeng, Mohamed Lamine Diao, Mamadou D Beye, Johana Montero Ortiz, Tarek Razek, Dan L Deckelbaum, Ibrahim Konate
BACKGROUND: Most low- and middle-income countries do not have a mature prehospital system limiting access to definitive care. This study sought to describe the current state of the prehospital system in Senegal and offer recommendations aimed at improving system capacity and population access to definitive care. METHODS: Structured interviews were conducted with key informants in various regions throughout the country using qualitative and quantitative techniques...
March 16, 2024: World Journal of Surgery
https://read.qxmd.com/read/38491025/the-study-on-the-appearance-of-deformation-defects-in-the-yacht-lamination-process-using-an-ai-algorithm-and-expert-knowledge
#4
JOURNAL ARTICLE
Paweł Szalewski, Tacjana Niksa-Rynkiewicz, Mariusz Deja
This article describes the application of the A-priori algorithm for defining the rule-based relationships between individual defects caused during the lamination process, affecting the deformation defect of the yacht shell. The data from 542 yachts were collected and evaluated. For the proper development of the algorithm, a technological process of the yacht lamination supported by expert decisions was described. The laminating technology is a complex process of a sequential application of individual laminates according to a special strategy...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490323/fabrication-trueness-and-margin-quality-of-additively-manufactured-resin-based-definitive-laminate-veneers-with-different-restoration-thicknesses
#5
JOURNAL ARTICLE
Gülce Çakmak, Mustafa Borga Donmez, Deniz Yılmaz, Hyung-In Yoon, Çiğdem Kahveci, Samir Abou-Ayash, Burak Yilmaz
OBJECTIVES: To evaluate how restoration thickness (0.5 mm and 0.7 mm) affects the fabrication trueness of additively manufactured definitive resin-based laminate veneers, and to analyze the effect of restoration thickness and margin location on margin quality. METHODS: Two maxillary central incisors were prepared either for a 0.5 mm- or 0.7 mm-thick laminate veneer. After acquiring the partial-arch scans of each preparation, laminate veneers were designed and stored as reference data...
March 13, 2024: Journal of Dentistry
https://read.qxmd.com/read/38489908/growing-coastal-tourism-can-biomonitoring-provide-insights-into-the-health-of-coastal-ecosystems
#6
JOURNAL ARTICLE
Imane Lamine, Bilal Mghili, Abir Chahouri, Mourad Aqnouy, Abdellatif Moukrim, Aicha Ait Alla
Coastal tourism's surge raises concerns for Morocco's Agadir marine environment, notably with Taghazout Bay's impact. Our study assesses Taghazout's health, employing a comprehensive approach. Our study evaluates Taghazout's health, adopting a comprehensive approach covering physicochemical, microbiological aspects, macrobenthic fauna, metal pollution, and biomarkers in D. trunculus mollusks. Seawater quality aligns with Moroccan standards, indicating good bathing water. The intertidal zone hosts ten species, dominated by D...
March 14, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38485766/lamin-b1-curtails-early-human-papillomavirus-infection-by-safeguarding-nuclear-compartmentalization-and-autophagic-capacity
#7
JOURNAL ARTICLE
Freya Molenberghs, Marlies Verschuuren, Lauran Vandeweyer, Sarah Peeters, Johannes J Bogers, Claudina Perez Novo, Wim Vanden Berghe, Hans De Reu, Nathalie Cools, Mario Schelhaas, Winnok H De Vos
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes lacking the major lamins with a HPV16 pseudovirus (HP-PsV) encoding an EGFP reporter. We found that a sustained reduction or complete loss of lamin B1 significantly increased HP-PsV infection rate...
March 14, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38483488/hydrothermal-assisted-synthesis-of-sr-doped-sns-nanoflower-catalysts-for-photodegradation-of-metronidazole-antibiotic-pollutant-in-wastewater-promoted-by-natural-sunlight-irradiation
#8
JOURNAL ARTICLE
Tayeb Bouarroudj, Youcef Messai, Lamine Aoudjit, Beddiaf Zaidi, Djamila Zioui, Amel Bendjama, Samiha Mezrag, Abdelmounaim Chetoui, Ilyas Belkhettab, Khaldoun Bachari
In this study, we report a facile hydrothermal synthesis of strontium-doped SnS nanoflowers that were used as a catalyst for the degradation of antibiotic molecules in water. The prepared sample was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and ultraviolet-visible absorption spectroscopy (UV-Vis). The photocatalytic ability of the strontium-doped SnS nanoflowers was evaluated by studying the degradation of metronidazole in an aqueous solution under photocatalytic conditions...
March 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://read.qxmd.com/read/38482663/dna-methylation-marker-identification-and-poly-methylation-risk-score-in-prediction-of-healthspan-termination
#9
JOURNAL ARTICLE
Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai
Aim: To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. Materials & methods: Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST. Then, a poly-methylation risk score (PMRS) was established in 241,008 individuals from the UK Biobank. Results: Of the 63,046 CpGs from the prediction models, 13 novel CpGs were associated with HST...
March 14, 2024: Epigenomics
https://read.qxmd.com/read/38480902/dysregulated-creb3-cleavage-at-the-nuclear-membrane-induces-karyoptosis-mediated-cell-death
#10
JOURNAL ARTICLE
Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Young-Soo Hong, Dae Joon Kim, Megan Keniry, Jin Young Kim, Jin-Sung Choi, Manolis Fanto, Sung-Jun Cho, Kwang-Dong Kim, Yong-Yeon Cho
Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for developing new therapies. Our research identified cyclic AMP-responsive element-binding protein 3 (CREB3) as a crucial regulator and initiator of a unique cell death mechanism known as karyoptosis. This process is characterized by nuclear shrinkage, deformation, and the loss of nuclear components following nuclear membrane rupture...
March 13, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38480822/an-electromechanical-stimulation-regulating-model-with-flexoelectric-effect-of-piezoelectric-laminated-micro-beam-for-cell-bionic-culture
#11
JOURNAL ARTICLE
Wei-Feng Rao, Ya-Wen Wang, An-Qing Li, Sha-Sha Zhou, Zu-Mei Zheng
Cell bionic culture requires the construction of cell growth microenvironments. In this paper, mechanical force and electrical stimulations are applied to the cells cultured on the surface of the piezoelectric laminated micro-beam driven by an excitation voltage. Based on the extended dielectric theory, the electromechanical microenvironment regulating model of the current piezoelectric laminated micro-beam is established. The variational principle is used to obtain the governing equations and boundary conditions...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38480012/preparation-of-ultrathin-translucent-zirconia-laminate-veneers-using-3d-printing-reduction-guides
#12
JOURNAL ARTICLE
Mahinour Yousry, Ihab Hammad, Mohamed El Halawani, Moustafa Aboushelib
Minimizing and controlling the amount of tooth reduction during the preparation of ultrathin laminate veneers is a challenge for minimally invasive dentistry. The use of reduction guides is advised to reach the optimal space required for the definitive restoration without excessive reduction. The digital production of a reduction guide used to control tooth preparation for ultrathin laminate veneers is described.
March 12, 2024: Journal of Prosthetic Dentistry
https://read.qxmd.com/read/38479880/examination-of-permeation-resistance-of-chemical-protective-gloves-made-of-laminate-film-materials-against-chemical-substances
#13
JOURNAL ARTICLE
Takamasa Aoki, Hiroyuki Miyauchi
This study investigated the permeation resistance of chemical protective gloves made of laminate film comprising nylon, ethylene-vinyl alcohol copolymer (EVOH), and other materials against different chemical substances to examine their usability in different work processes. The permeation resistance of the chemical protective glove was tested using the Japanese Industrial Standards (JIS) test method against twelve substances: acetone, acetonitrile, dichloromethane, ethyl acetate, n-hexane, methanol, tetrahydrofuran, toluene, 2-propanol, 1-butanol, 1,4-diethylene dioxide, and ethanol...
2024: Journal of UOEH
https://read.qxmd.com/read/38477063/the-predominance-of-astrocytic-intranuclear-inclusions-in-neuronal-intranuclear-inclusion-disease-manifesting-encephalopathy-like-symptoms-a-case-series-with-brain-biopsy
#14
Keisuke Ishizawa, Takashi Komori, Taku Homma, Jun Sone, Yasuhiro Nakata, Yoshihiko Nakazato, Kazushi Takahashi, Toshimasa Yamamoto, Atsushi Sasaki
Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder represented by eosinophilic intranuclear inclusions (EIIs) and GGC/CGG repeat expansion in the NOTCH2NLC gene. We report here two adult cases of NIID, genetically confirmed, with manifestation of encephalopathy-like symptoms and address the histopathologic findings obtained by brain biopsies, with a focus on "astrocytic" intranuclear inclusions (AIIs). Case 1 presented with paroxysmal restlessness, vertigo, or fever and was later involved in severe dementia and tetraparesis...
March 13, 2024: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/38475400/impact-behavior-and-residual-strength-of-peek-cf-laminated-composites-with-various-stacking-sequences
#15
JOURNAL ARTICLE
Alexander V Eremin, Mikhail V Burkov, Alexey A Bogdanov, Anastasia A Kononova, Pavel S Lyubutin
Carbon fiber-reinforced composites are popular due to their high strength and light weight; thus, the structures demonstrate high performance and specific strength. However, these composites are susceptible to impact damage. The objective of this research was to study the behavior of carbon fiber-reinforced laminates based on a polyetheretherketone (PEEK) matrix with six stacking sequences under static and impact loading. Four-point bending, short-beam bending, drop weight impact, and compression after impact tests were carried out...
March 6, 2024: Polymers
https://read.qxmd.com/read/38475388/global-sensitivity-analysis-of-factors-influencing-the-surface-temperature-of-mold-during-autoclave-processing
#16
JOURNAL ARTICLE
Jiayang He, Lihua Zhan, Youliang Yang, Yongqian Xu
During the process of forming carbon fiber reinforced plastics (CFRP) in an autoclave, deeply understanding the global sensitivity of factors influencing mold surface temperature is of paramount importance for optimizing large frame-type mold thermally and enhancing curing quality. In this study, the convective heat transfer coefficient (CHTC), the thickness of composite laminates (TCL), the thickness of mold facesheet (TMF), the mold material type (MMT), and the thickness of the auxiliary materials layer (TAL) have been quantitatively assessed for the effects on the mold surface temperature...
March 5, 2024: Polymers
https://read.qxmd.com/read/38475348/tensile-and-compressive-properties-of-woven-fabric-carbon-fiber-reinforced-polymer-laminates-containing-three-dimensional-microvascular-channels
#17
JOURNAL ARTICLE
Ziqian An, Xiaoquan Cheng, Dafang Zhao, Yihao Ma, Xin Guo, Yujia Cheng
Microvascular self-healing composite materials have significant potential for application and their mechanical properties need in-depth investigation. In this paper, the tensile and compressive properties of woven fabric carbon fiber-reinforced polymer (CFRP) laminates containing three-dimensional microvascular channels were investigated experimentally. Several detailed finite element (FE) models were established to simulate the mechanical behavior of the laminate and the effectiveness of different models was examined...
February 29, 2024: Polymers
https://read.qxmd.com/read/38475290/mechanical-and-thermal-analysis-of-duroplastic-matrix-composites-over-a-range-of-temperatures
#18
JOURNAL ARTICLE
Anna Krzak, Agnieszka J Nowak, Marcin Heljak, Jerzy Antonowicz, Tushar Garg, Michael Sumption
It is commonly acknowledged that polymer composites in service are often subjected to not only intricate mechanical loads but also harsh environmental conditions. The mechanical and thermal properties of five particular composites are explored here. The composites are composed of laminates of glass cloth type "E" sheet infilled with a duroplastic matrix. This is a thermoset polymer-epoxy resin with different molecular weights. The composites were fabricated by IZOERG company, which is based in Poland. The final articles were 1...
February 23, 2024: Polymers
https://read.qxmd.com/read/38475278/numerical-modelling-of-the-thermoforming-behaviour-of-thermoplastic-honeycomb-composite-sandwich-laminates
#19
JOURNAL ARTICLE
Varun Kumar Minupala, Matthias Zscheyge, Thomas Glaesser, Maik Feldmann, Holm Altenbach
Lightweight component design is effectively achievable through sandwich structures; many past research studies in the aerospace and racing sectors (since the 1920s) have proven it. To extend their application into the automotive and other transport industries, manufacturing cycle times must be reduced. This can be achieved by sandwich materials made of continuous fibre-reinforced thermoplastic (CFRTP) cover layers and thermoplastic honeycomb cores. To widen the application of flat thermoplastic-based sandwich panels into complex parts, a novel forming technology was developed by the Fraunhofer Institute of Microstructure of Materials and Systems (IMWS)...
February 21, 2024: Polymers
https://read.qxmd.com/read/38474958/advanced-dielectric-resonator-antenna-technology-for-5g-and-6g-applications
#20
REVIEW
Yingqi Zhang, Stanislav Ogurtsov, Vasilii Vasilev, Ahmed A Kishk, Diego Caratelli
We review dielectric resonator antenna (DRA) designs. This review examines recent advancements across several categories, specifically focusing on their applicability in array configurations for millimeter-wave (mmW) bands, particularly in the context of 5G and beyond 5G applications. Notably, the off-chip DRA designs, including in-substrate and compact DRAs, have gained prominence in recent years. This surge in popularity can be attributed to the rapid development of cost-effective multilayer laminate manufacturing techniques, such as printed circuit boards (PCBs) and low-temperature co-fired ceramic (LTCC)...
February 22, 2024: Sensors
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