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https://www.readbyqxmd.com/read/27905138/efficient-and-air-stable-mixed-cation-lead-mixed-halide-perovskite-solar-cells-with-n-doped-organic-electron-extraction-layers
#1
Zhiping Wang, David P McMeekin, Nobuya Sakai, Stephan van Reenen, Konrad Wojciechowski, Jay B Patel, Michael B Johnston, Henry J Snaith
Air-stable doping of the n-type fullerene layer in an n-i-p planar heterojunction perovskite device is capable of enhancing device efficiency and improving device stability. Employing a (HC(NH2 )2 )0.83 Cs0.17 Pb(I0.6 Br0.4 )3 perovskite as the photoactive layer, glass-glass laminated devices are reported, which sustain 80% of their "post burn-in" efficiency over 3400 h under full sun illumination in ambient conditions.
December 1, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27901466/differentiation-alters-stem-cell-nuclear-architecture-mechanics-and-mechano-sensitivity
#2
Su-Jin Heo, Tristan P Driscoll, Stephen D Thorpe, Nandan L Nerurkar, Brendon M Baker, Michael T Yang, Christopher S Chen, David A Lee, Robert L Mauck
Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation. Our data show that nuclei in differentiated bovine and human MSCs stiffen and become resistant to deformation. This attenuated nuclear deformation was governed by restructuring of Lamin A/C and increased heterochromatin content. This change in nuclear stiffness sensitized MSCs to mechanical loading induced calcium signaling and differentiated marker expression...
November 30, 2016: ELife
https://www.readbyqxmd.com/read/27900294/efficacy-of-autologous-leukocyte-reduced-platelet-rich-plasma-therapy-for-patellar-tendinopathy-in-a-rat-treadmill-model
#3
Mamoru Yoshida, Hiroki Funasaki, Keishi Marumo
BACKGROUND: An autologous platelet-rich plasma (PRP) therapy has currently been applied for the tendinopathy; however, its efficacy and an optimal platelets concentration in PRP were uncertain. We analyzed them in an animal model prepared using a repetitive running exercise. METHODS: We made the tendinopathy rat model of patellar tendon using a rodent treadmill machine. Rats with tendinopathy were injected with leukocyte-reduced PRP at the platelets concentration of 1...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27891508/effect-of-water-activity-and-packaging-material-on-the-quality-of-dehydrated-taro-colocasia-esculenta-l-schott-slices-during-accelerated-storage
#4
A R Sloan, M L Dunn, L K Jefferies, O A Pike, Sarah E Nielsen Barrows, F M Steele
The quality of dehydrated taro slices in accelerated storage (45°C and 75% RH) was determined as a function of initial water activity (aw) and package type. Color, rehydration capacity, thiamin content, and α-tocopherol content were monitored during 34 weeks of storage in polyethylene and foil laminate packaging at initial storage aw of 0.35 to 0.71. Initial aw at or below 0.54 resulted in less browning and higher rehydration capacity, but not in significantly higher α-tocopherol retention. Foil laminate pouches resulted in a higher rehydration capacity and increased thiamin retention compared to polyethylene bags...
2016: International journal of food science
https://www.readbyqxmd.com/read/27889148/surface-attachment-of-active-antimicrobial-coatings-onto-conventional-plastic-based-laminates-and-performance-assessment-of-these-materials-on-the-storage-life-of-vacuum-packaged-beef-sub-primals
#5
David Clarke, Andrey A Tyuftin, Malco C Cruz-Romero, Declan Bolton, Seamus Fanning, Shashi K Pankaj, Carmen Bueno-Ferrer, Patrick J Cullen, Joe P Kerry
Two antimicrobial coatings, namely Sodium octanoate and Auranta FV (a commercial antimicrobial composed of bioflavonoids, citric, malic, lactic, and caprylic acids) were used. These two antimicrobials were surface coated onto the inner polyethylene layer of cold plasma treated polyamide films using beef gelatin as a carrier and coating polymer. This packaging material was then used to vacuum pack beef sub-primal cuts and stored at 4 °C. A control was prepared using the non-coated commercial laminate and the same vacuum packaged sub-primal beef cuts...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27888261/fluctuating-residual-limb-volume-accommodated-with-an-adjustable-modular-socket-design-a-novel-case-report
#6
Kay Mitton, Jai Kulkarni, Kenneth William Dunn, Anthony Hoang Ung
BACKGROUND: This novel case report describes the problems of prescribing a prosthetic socket in a left transfemoral amputee secondary to chronic patellofemoral instability compounded by complex regional pain syndrome. CASE DESCRIPTION AND METHODS: Following the amputation, complex regional pain syndrome symptoms recurred in the residual limb, presenting mainly with oedema. Due to extreme daily volume fluctuations of the residual limb, a conventional, laminated thermoplastic socket fitting was not feasible...
November 24, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27884250/the-significant-arrhythmia-and-cardiomyopathy-burden-of-lamin-a-c-mutations
#7
EDITORIAL
Michael D Taylor, Jeffrey A Towbin
No abstract text is available yet for this article.
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27884249/long-term-arrhythmic-and-nonarrhythmic-outcomes-of-lamin-a-c-mutation-carriers
#8
Saurabh Kumar, Samuel H Baldinger, Estelle Gandjbakhch, Philippe Maury, Jean-Marc Sellal, Alexander F A Androulakis, Xavier Waintraub, Philippe Charron, Anne Rollin, Pascale Richard, William G Stevenson, Ciorsti J Macintyre, Carolyn Y Ho, Tina Thompson, Jitendra K Vohra, Jonathan M Kalman, Katja Zeppenfeld, Frederic Sacher, Usha B Tedrow, Neal K Lakdawala
BACKGROUND: Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain. OBJECTIVES: This study sought to describe the arrhythmic and nonarrhythmic outcomes of LMNA mutation carriers and to assess the prognostic significance of the index cardiac phenotype...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27883036/the-mevalonate-pathway-regulates-primitive-streak-formation-via-protein-farnesylation
#9
Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M Penninger, Sachiko Nishina, Noriyuki Azuma, Hiroshi Nishina
The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-characterised drugs to identify these metabolic factors. We found that statins, which inhibit the mevalonate metabolic pathway, suppressed primitive streak formation in vitro and in vivo. Using metabolomics and pharmacologic approaches we identified the downstream signalling pathway of mevalonate and revealed that primitive streak formation requires protein farnesylation but not cholesterol synthesis...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27877878/a-transparent-solvent-free-laminated-top-electrode-for-perovskite-solar-cells
#10
Mohammed Makha, Silvia Letícia Fernandes, Sandra Jenatsch, Ton Offermans, Jürg Schleuniger, Jean-Nicolas Tisserant, Anna C Véron, Roland Hany
A simple lamination process of the top electrode for perovskite solar cells is demonstrated. The laminate electrode consists of a transparent and conductive plastic/metal mesh substrate, coated with an adhesive mixture of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate), PEDOT:PSS, and sorbitol. The laminate electrode showed a high degree of transparency of 85%. Best cell performance was achieved for laminate electrodes prepared with a sorbitol concentration of ~30 wt% per milliliter PEDOT:PSS dispersion, and using a pre-annealing temperature of 120°C for 10 min before lamination...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877105/extended-postnatal-brain-development-in-the-longest-lived-rodent-prolonged-maintenance-of-neotenous-traits-in-the-naked-mole-rat-brain
#11
Miranda E Orr, Valentina R Garbarino, Angelica Salinas, Rochelle Buffenstein
The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan >31 years. Intriguingly, fully-grown naked mole-rats (NMRs) exhibit many traits typical of neonatal rodents. However, little is known about NMR growth and maturation, and we question whether sustained neotenous features when compared to mice, reflect an extended developmental period, commensurate with their exceptionally long life. We tracked development from birth to 3 years of age in the slowest maturing organ, the brain, by measuring mass, neural stem cell proliferation, axonal, and dendritic maturation, synaptogenesis and myelination...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27876764/seep-carbonate-lamination-controlled-by-cyclic-particle-flux
#12
Tobias Himmler, Germain Bayon, David Wangner, Frieder Enzmann, Jörn Peckmann, Gerhard Bohrmann
Authigenic carbonate build-ups develop at seafloor methane-seeps, where microbially mediated sulphate-dependent anaerobic oxidation of methane facilitates carbonate precipitation. Despite being valuable recorders of past methane seepage events, their role as archives of atmospheric processes has not been examined. Here we show that cyclic sedimentation pulses related to the Indian monsoon in concert with authigenic precipitation of methane-derived aragonite gave rise to a well-laminated carbonate build-up within the oxygen minimum zone off Pakistan (northern Arabian Sea)...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876398/dropped-head-congenital-muscular-dystrophy-caused-by-de-novo-mutations-in-lmna
#13
Pakize Karaoglu, Nicolas Quizon, Matthias Pergande, Haicui Wang, Ayşe Ipek Polat, Ayca Ersen, Erdener Özer, Lena Willkomm, Semra Hiz Kurul, Raúl Heredia, Uluç Yis, Duygu Selcen, Sebahattin Çirak
BACKGROUND: Dropped head syndrome is an easily recognizable clinical presentation of Lamin A/C-related congenital muscular dystrophy. Patients usually present in the first year of life with profound neck muscle weakness, dropped head, and elevated serum creatine kinase. CASE DESCRIPTION: Two patients exhibited head drop during infancy although they were able to sit independently. Later they developed progressive axial and limb-girdle weakness. Creatine kinase levels were elevated and muscle biopsies of both patients showed severe dystrophic changes...
November 19, 2016: Brain & Development
https://www.readbyqxmd.com/read/27876296/pathogenic-features-of-clinically-significant-coagulase-negative-staphylococci-in-hospital-and-community-infections-in-benin
#14
Chimène Nanoukon, Xavier Argemi, Frédéric Sogbo, Jeanne Orekan, Daniel Keller, Dissou Affolabi, Frédéric Schramm, Philippe Riegel, Lamine Baba-Moussa, Gilles Prévost
In West Africa, very little consideration has been given to coagulase negative Staphylococci (CNS). Herein, we describe the features contributing to the pathogenicity of 99 clinically-significant independent CNS isolates associated with infections encountered at the National Teaching Hospital Center of Cotonou (Benin). The pathogenic potentials of nosocomial strains were compared with community strains. S. haemolyticus (44%), S. epidermidis (22%) and S. hominis (7%) were the most frequently isolated while bacteremia (66...
November 10, 2016: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/27875985/nuclear-envelope-structural-defect-underlies-the-main-cause-of-aneuploidy-in-ovarian-carcinogenesis
#15
Callinice D Capo-Chichi, Toni M Yeasky, Elizabeth R Smith, Xiang-Xi Xu
BACKGROUND: The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is extensive aneuploidy caused by chromosomal numerical instability, which is thought to promote malignant transformation. Conventionally, aneuploidy is thought to be the result of mitotic errors and chromosomal nondisjunction during mitosis. Previously, we found that ovarian cancer cells often lost or reduced nuclear lamina proteins lamin A/C, and suppression of lamin A/C in cultured ovarian epithelial cells leads to aneuploidy...
November 22, 2016: BMC Cell Biology
https://www.readbyqxmd.com/read/27874871/mass-spectrometry-captures-off-target-drug-binding-and-provides-mechanistic-insights-into-the-human-metalloprotease-zmpste24
#16
Shahid Mehmood, Julien Marcoux, Joseph Gault, Andrew Quigley, Susan Michaelis, Stephen G Young, Elisabeth P Carpenter, Carol V Robinson
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets. However, distinguishing the binding of drugs to membrane proteins from that of detergents, lipids and cofactors is challenging. Here, we use high-resolution mass spectrometry to study the effects of HIV protease inhibitors on the human zinc metalloprotease ZMPSTE24. This intramembrane protease plays a major role in converting prelamin A to mature lamin A...
December 2016: Nature Chemistry
https://www.readbyqxmd.com/read/27871065/mechanical-remodeling-of-normally-sized-mammalian-cells-under-a-gravity-vector
#17
Chen Zhang, Lüwen Zhou, Fan Zhang, Dongyuan Lü, Ning Li, Lu Zheng, Yanhong Xu, Zhan Li, Shujin Sun, Mian Long
Translocation of the dense nucleus along a gravity vector initiates mechanical remodeling of a cell, but the underlying mechanisms of cytoskeletal network and focal adhesion complex (FAC) reorganization in a mammalian cell remain unclear. We quantified the remodeling of an MC3T3-E1 cell placed in upward-, downward-, or edge-on-orientated substrate. Nucleus longitudinal translocation presents a high value in downward orientation at 24 h or in edge-on orientation at 72 h, which is consistent with orientation-dependent distribution of perinuclear actin stress fibers and vimentin cords...
November 8, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27869543/direct-bonding-of-chitosan-biomaterials-to-tissues-using-transglutaminase-for-surgical-repair-or-device-implantation
#18
Javier Fernandez, Suneil Seetharam, Christopher Ding, Edward Doherty, Donald Ingber
Natural biomaterials, such as chitosan and collagen, are useful for biomedical applications because they are biocompatible, mechanically robust and biodegradable, but it is difficult to rapidly and tightly bond them to living tissues. Here, we demonstrate that the microbial enzyme transglutaminase (mTG) can be used to rapidly (< 5 min) bond chitosan and collagen biomaterials to the surfaces of hepatic, cardiac and dermal tissues, as well as to functionalized polydimethylsiloxane (PDMS) materials that are used in medical products...
November 21, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27867062/evaluation-of-convalescent-whole-blood-for-treating-ebola-virus-disease-in-freetown-sierra-leone
#19
F Sahr, R Ansumana, T A Massaquoi, B R Idriss, F R Sesay, J M Lamin, S Baker, S Nicol, B Conton, W Johnson, O T Abiri, O Kargbo, P Kamara, A Goba, J W B Russell, S M Gevao
BACKGROUND: Convalescent blood therapy has been a promising form of treatment for Ebola Virus Disease (EVD), but less attention has been focused on it for treatment. METHOD: We assessed the effectiveness of convalescent whole blood (CWB) in the treatment of consented EVD patients. We recruited 69 subjects in December 2014 up to April 2015, at the 34 Military Hospital in Wilberforce, Freetown. Forty-four were given CWB, and 25 who consented but preferred to be exempted from the CWB treatment were used to compare clinical outcomes...
November 17, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27865954/laminating-of-chemically-modified-silan-based-nanosols-for-advanced-functionalization-of-cotton-textiles
#20
Amina L Mohamed, Mehrez E El-Naggar, Th I Shaheen, Ahmed G Hassabo
As per to silver nanoparticles/silicon dioxide nanoparticles (SiO2@AgNPs) properties (e.g., conductivity, reactant, adsorption, detachment and antimicrobial), many researchers were focused on its preparation technique. A core/shell of silicon dioxide and silver nanoparticles (SiO2@AgNPs) has been prepared by facile route. The as synthesized core/shell nanoparticles were chemically modified with two different silan compounds, nominated, vinyltriethoxysilan (VTEOS) and (3-aminopropyl)trimethoxysilan (APTEOS)...
November 16, 2016: International Journal of Biological Macromolecules
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