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Arantza Infante, Clara I Rodríguez
Aging is a complex biological process, which involves multiple mechanisms with different levels of regulation. Senescent cells are known to secrete senescence-associated proteins, which exert negative influences on surrounding cells. Mesenchymal stem cells (MSCs), the common progenitors for bone, cartilage and adipose tissue (which are especially affected tissues in aging), are known to secrete a broad spectrum of biologically active proteins with both paracrine and autocrine functions in many biological processes...
March 15, 2018: Scientific Reports
Federico Vilaplana Grosso, Stacy Tinkler, Mario Sola, Margaret Miller, Hock Gan Heng
A 2-year-old Boer doe was presented with respiratory distress and severe inspiratory dyspnea. Cervical and thoracic radiographs revealed a marked retropharyngeal soft tissue mass effect, several mineralized pharyngeal and retropharyngeal structures, and a pulmonary mass. Computed tomography (CT) revealed a severely enlarged right medial retropharyngeal lymph node, which caused laryngeal compression, leading to upper airway obstruction. Multiple cervical and thoracic lymph nodes, and the pulmonary mass had an irregular layered/laminated pattern of mineralization...
March 15, 2018: Veterinary Radiology & Ultrasound
F Guégan, W Lamine, H Chermette, C Morell
In a recent article Polanco-Ramirez et al. proposed new definitions of local chemical potential and local hardness starting from the first derivative of the energy with respect to the number of electrons and a smart use of the chain rule. In this comment we show that this derivation appears naturally in the Taylor expansion of the energy, showing that the construction of Polanco-Ramirez et al. is not artificially built.
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Jingjing Yang, Dian Gong, Guihua Li, Gaofeng Zeng, Qiyan Wang, Yelei Zhang, Guojuan Liu, Ping Wu, Evgeny Vovk, Zheng Peng, Xiaohong Zhou, Yong Yang, Zhi Liu, Yuhan Sun
The poor mechanical strength of graphene oxide (GO) membranes, caused by the weak interlamellar interactions, poses a critical challenge for any practical application. In addition, intrinsic but large-sized 2D channels of stacked GO membranes lead to low selectivity for small molecules. To address the mechanical strength and 2D channel size control, thiourea covalent-linked graphene oxide framework (TU-GOF) membranes on porous ceramics are developed through a facile hydrothermal self-assembly synthesis. With this strategy, thiourea-bridged GO laminates periodically through the dehydration condensation reactions via NH2 and/or SH with OCOH as well as the nucleophilic addition reactions of NH2 to COC, leading to narrowed and structurally well-defined 2D channels due to the small dimension of the covalent TU-link and the deoxygenated processes...
March 14, 2018: Advanced Materials
Hyung Wook Park, Hong-Lim Kim, Yong Soo Park, In-Beom Kim
The retina is a highly specialised part of the brain responsible for visual processing. It is well-laminated; three layers containing five different types of neurons are compartmentalised by two synaptic layers. Among the retinal layers, the inner nuclear layer (INL) is composed of horizontal, bipolar, and amacrine cell types. Bipolar cells form one sublayer in the distal half of the IPL, while amacrine cells form another sublayer in the proximal half, without any border-like structure. Here, we report that a plexiform layer-like structure exists temporarily in the border between the bipolar and amacrine sublayers in the INL in the rat retina during retinal development...
February 2018: Experimental Neurobiology
Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W Schafer, Denis Wirtz, Dong-Hwee Kim
In the original version of this Article, the affiliation details for Arghavan Louhghalam were incorrectly given as 'Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, 21218, USA', and it should have been given as 'Department of Civil and Environmental Engineering, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA'. Furthermore, an incorrect grant number, R1610512, was acknowledged. The correct grant number is NRF-2016R1C1B2015018. These errors have now been corrected in both the PDF and HTML versions of the Article...
March 13, 2018: Nature Communications
Anqi Dong, Yan Zhao, Xinqing Zhao, Qiyong Yu
Out-of-autoclave prepreg typically needs a long cure cycle to guarantee good properties as the result of low processing pressure applied. It is essential to reduce the manufacturing time, achieve real cost reduction, and take full advantage of out-of-autoclave process. The focus of this paper is to reduce the cure cycle time and production cost while maintaining high laminate quality. A rapidly cured out-of-autoclave resin and relative prepreg were independently developed. To determine a suitable rapid cure procedure for the developed prepreg, the effect of heating rate, initial cure temperature, dwelling time, and post-cure time on the final laminate quality were evaluated and the factors were then optimized...
March 13, 2018: Materials
Elías López-Alba, Sebastian Schmeer, Francisco Díaz
The study of natural fiber reinforcement composite structures has focused the attention of the automobile industry due to the new regulation in relation to the recyclability and the reusability of the materials preserving and/or improving the mechanical characteristics. The influence of different parameters on the material behavior of natural fiber reinforced plastic structures has been investigated, showing the potential for transport application in energy absorbing structures. Two different woven fabrics (twill and hopsack) made of flax fibers as well as a non-woven mat made of a mixture of hemp and kenaf fibers were employed as reinforcing materials...
March 13, 2018: Materials
Nejla Sellami, Laila Ben Lamine, Amira Turki, Sameh Sarray, Mohammed Jailani, Abrar K Al-Ansari, Mohamed Ghorbel, Touhami Mahjoub, Wassim Y Almawi
BACKGROUND: Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis. AIM: To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisians. SUBJECTS AND METHODS: A retrospective case-control study, performed on 815 T2DM patients, and 805 healthy controls. VEGF levels were measured by ELISA, genotyping of VEGFA variants was done by allelic exclusion method (real-time PCR)...
March 10, 2018: Cytokine
Chang-Ming Wang, Chia-Han Hsieh, Chong-You Chen, Wei-Ssu Liao
Aiming to overcome the obstacles of power supply requirement and chip usefulness in practice, a low-cost and convenient portable electrochemical sensing device is introduced for the first time, featuring bipolar electrode system, LED read-out, laminated paper-based devices, and low-voltage button cells. The electric circuits of this practical device are constructed on laminating films with copper and conductive carbon tapes, and the reservoirs facilitating chemical reactions are made with chromatography paper...
July 26, 2018: Analytica Chimica Acta
Vincent Mazel, Harona Diarra, Jérôme Malvestio, Pierre Tchoreloff
Capping and lamination are common industrial problems during the manufacturing of pharmaceutical tablets. Even if they are commonly treated together, these phenomena correspond to different failure patterns of the tablet and, as a consequence, to different mechanisms of cracking. In this work, a specific case of lamination of biconvex tablets was studied. It corresponds to a breakage into two parts of the tablets along a failure plan normal to the compression direction and located approximately at the center of the tablet band...
March 8, 2018: International Journal of Pharmaceutics
Dalila Rahali, Aicha Jrad-Lamine, Yosra Dallagi, Yassine Bdiri, Nathalie Ba, Michele El May, Saloua El Fazaa, Narges El Golli
Electronic (e)-cigarettes are devices intended to substitute conventional cigarettes, with the aim of being less harmful. In a previous report, we showed that i.p. injection of e-cigarette liquid (e-liquid), with or without nicotine, induced toxicity in the testes of Wistar rats by disrupting oxidative balance and steroidogenesis. In the present work, we further evaluated the impact of e-liquid with or without nicotine on the epididymis of rats using the same procedure. Results showed that e-liquid treatments led to alteration of semen parameters, with a significant drop of at least 50% in sperm vitality, a significant increase of morphologically abnormal spermatozoa and an imbalance of redox status in comparison to the control group...
March 12, 2018: Chinese Journal of Physiology
May S Freag, Wedad M Saleh, Ossama Y Abdallah
In the current study, laminated chitosan (CS):hydroxypropyl methylcellulose (HPMC) composite sponges were exploited as solid matrices for buccal delivery of tripterine phytosomes functionalized with novel mucopenetrating protamine layer (PRT-TRI-PHY). Tripterine (TRI) is a herbal drug widely investigated as a potential anticancer candidate against various types of cancers. However, clinical use of TRI is handicapped by its low oral bioavailability. To surmount TRI pharmaceutical obstacles, TRI phytosomes (TRI-PHY) were prepared using solvent evaporation technique then coated with a protamine layer via electrostatic assembly process...
May 15, 2018: Carbohydrate Polymers
Giulia Ognibene, Salvatore Mannino, Maria Elena Fragalà, Gianluca Cicala
Electrospun veils from copolyethersulfones (coPES) were prepared as soluble interlaminar veils for carbon fiber/epoxy composites. Neat, resin samples were impregnated into coPES veils with unmodified resin, while dry carbon fabrics were covered with electrospun veils and then infused with the unmodified epoxy resin to prepare reinforced laminates. The thermoplastic content varied from 10 wt% to 20 wt%. TGAP epoxy monomer showed improved and fast dissolution for all the temperatures tested. The unreinforced samples were cured first at 180 °C for 2 h and then were post-cured at 220 °C for 3 h...
March 9, 2018: Materials
William T Gough, Frank E Fish, Dylan K Wainwright, Hilary Bart-Smith
The cetacean tail fluke blades are not supported by any vertebral elements. Instead, the majority of the blades are composed of a densely packed collagenous fiber matrix known as the core layer. Fluke blades from six species of odontocete cetaceans were examined to compare the morphology and orientation of fibers at different locations along the spanwise and chordwise fluke blade axes. The general fiber morphology was consistent with a three-dimensional structure comprised of two-dimensional sheets of fibers aligned tightly in a laminated configuration along the spanwise axis...
March 9, 2018: Journal of Morphology
O Ustun, A N Ozturk
Background: Fractures in porcelain laminate veneers (PLVs) are a significant clinical problem. Preparation designs can affect stress distribution, which leads to fractures in PLVs. Therefore, identification of the most favorable preparation design in terms of stress distribution is required. Objective: The purpose of this study is to examine the functional stress patterns of PLVs with featheredge, incisal bevel, and overlapped preparation designs under 0°, 60°, and 120° functional loads using finite element analysis...
March 2018: Nigerian Journal of Clinical Practice
Nolwenn Briand, Philippe Collas
The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. Mutations in A-type nuclear lamins cause laminopathies, some of which are associated with a loss of heterochromatin at the nuclear periphery. Until recently however, little if any information has been provided on where and how lamin A interacts with the genome and on how disease-causing lamin A mutations may rearrange genome conformation. Here, we review aspects of nuclear lamin association with the genome. We highlight recent evidence of reorganization of lamin A-chromatin interactions in cellular models of laminopathies, and implications on the 3-dimensional rearrangement of chromatin in these models, including patient cells...
March 8, 2018: Nucleus
Erhan Tuğcu, Burçin Vanlıoğlu, Yasemin Kulak Özkan, Yilmat Umut Aslan
The purpose of this study was to evaluate the marginal adaptation and fracture load of ceramic laminate veneers on teeth with different preparation depths. A total of 75 extracted intact human maxillary central incisors were prepared with three different preparation depths (P) and assigned to the following five groups (n = 15): P1 (0.3-mm depth of preparation; preparation entirely in enamel); P2 (0.5-mm depth of preparation; preparation in enamel and dentin complex); P3 (1-mm depth of preparation; preparation entirely in dentin); P4 (no preparation, only surface roughening); and P5 (unrestored, intact teeth as control)...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
Jobin Varghese, Tuomo Siponkoski, Maciej Sobocinski, Timo Vahera, Heli Jantunen
This paper reports the first ultralow sintering temperature (450 oC) co-fired multifunctional ceramic substrate based on a commercial lead zirconium titanate (PZ29)-glass composite and fabricated by tape casting, isostatic lamination, and sintering. This substrate was prepared from a novel tape casting slurry composition suitable for co-firing at this low temperature with commercial Ag electrodes at 450 oC. The green cast tape and sintered substrate showed a surface roughness of 146 nm and 355 nm, respectively, suitable for device level fabrication by post-processing...
March 7, 2018: ACS Applied Materials & Interfaces
M Hempel, A-Y Lu, F Hui, T Kpulun, M Lanza, G Harris, T Palacios, J Kong
Two-dimensional (2D) materials such as graphene (Gr), molybdenum disulfide and hexagonal boron nitride (hBN) hold great promise for low-cost and ubiquitous electronics for flexible displays, solar cells or smart sensors. To implement this vision, scalable production, transfer and patterning technologies of 2D materials are needed. Recently, roll-to-roll (R2R) processing, a technique that is widely used in industry and known to be cost-effective and scalable, was applied to continuously grow and transfer graphene...
March 7, 2018: Nanoscale
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