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https://www.readbyqxmd.com/read/29772708/microstructure-evolution-and-mechanical-behavior-of-2219-aluminum-alloys-additively-fabricated-by-the-cold-metal-transfer-process
#1
Xuewei Fang, Lijuan Zhang, Hui Li, Chaolong Li, Ke Huang, Bingheng Lu
In this research, four different welding arc modes including conventional cold metal transfer (CMT), CMT-Pulse (CMT-P), CMT-Advanced (CMT-ADV), and CMT pulse advanced (CMT-PADV) were used to deposit 2219-Al wire. The effects of different arc modes on porosity, pore size distribution, microstructure evolution, and mechanical properties were thoroughly investigated. The statistical analysis of the porosity and its size distribution indicated that the CMT-PADV process gave the smallest pore area percentage and pore aspect ratio, and had almost no larger pores...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29772042/subfoveal-choroidal-thickness-as-a-potential-predictor-of-clinical-response-to-stereotactic-radiotherapy-for-neovascular-age-related-macular-degeneration
#2
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29770620/value-of-combined-adjuvant-chemotherapy-and-radiation-on-survival-for-stage-iii-uterine-cancer-is-less-radiation-equal-to-more
#3
Chiachien Jake Wang, Alana Christie, Michael R Folkert, Xian Jin Xie, Kevin Albuquerque
OBJECTIVE: Locally advanced endometrioid adenocarcinoma (LA-EAC) accounts for the majority of deaths for this cancer, yet there is no consensus on adjuvant treatment after surgery. Past studies suggest that combined modality treatment (CMT) may improve outcomes over treatment with chemotherapy (CT) or radiation therapy (RT, either external beam radiotherapy [EBRT] or vaginal brachytherapy [VBT]) alone. Using a large US-based population-based registry, we evaluated adjuvant CMT in LA-EAC and the relative benefit of regional EBRT compared to focused VBT...
March 6, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29757872/pattern-of-care-health-care-disparities-and-their-impact-on-survival-outcomes-in-stage-ivb-cervical-cancer-a-nationwide-retrospective-cohort-study
#4
Randa J Jalloul, Shelly Sharma, Celestine S Tung, Barrett OʼDonnell, Michelle Ludwig
OBJECTIVE: Although locally advanced cervical cancer can be cured, patients with stage IVB disease have poor prognosis with limited treatment options. Our aim was to describe the pattern of care and analyze health disparity variables that may account for differences in treatment modalities and survival in this population. METHODS: The National Cancer Database was queried for patients diagnosed between 2004 and 2013 with metastatic squamous cell carcinoma or adenocarcinoma of the cervix...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29742619/loss-of-function-mutation-in-hippo-suppressed-enlargement-of-lysosomes-and-neurodegeneration-caused-by-dfig4-knockdown
#5
Yukie Kushimura, Yumiko Azuma, Ikuko Mizuta, Yuuka Muraoka, Akane Kyotani, Hideki Yoshida, Takahiko Tokuda, Toshiki Mizuno, Masamitsu Yamaguchi
Charcot-Marie-Tooth disease (CMT) is the most common hereditary neuropathy, and more than 80 CMT-causing genes have been identified to date. CMT4J is caused by a loss-of-function mutation in the Factor-Induced-Gene 4 (FIG4) gene, the product of which plays important roles in endosome-lysosome homeostasis. We hypothesized that Mammalian sterile 20-like kinase (MST) 1 and 2, tumor-suppressor genes, are candidate modifiers of CMT4J. We therefore examined the interaction between dFIG4 and Hippo (hpo), Drosophila counterparts of FIG4 and MSTs, respectively, using the Drosophila CMT4J model with the knockdown of dFIG4...
May 8, 2018: Neuroreport
https://www.readbyqxmd.com/read/29742248/pain-in-charcot-marie-tooth-disease-an-update
#6
Helen Azevedo, Camila Pupe, Rouse Pereira, Osvaldo J M Nascimento
Charcot-Marie-Tooth (CMT) disease, the most common inherited peripheral neuropathy, has pain as one of its clinical features, yet it remains underdiagnosed and undertreated. This literature review assessed data related to pain from CMT to determine its prevalence, type and importance as a symptom, which, unlike other symptoms, is likely to be treated. The research encompassed 2007 to 2017 and included five articles that addressed pain from CMT. All of the papers concurred that pain is frequently present in CMT patients, yet its classification remains undefined as there has been no consensus in the literature about the mechanisms that cause it...
April 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29739877/role-of-kip2-during-early-mitosis-impact-on-spindle-pole-body-separation-and-chromosome-capture
#7
Beryl Augustine, Cheen Fei Chin, Foong May Yeong
Mitotic spindle dynamics are regulated during the cell cycle by microtubule motor proteins. One such protein is Kip2p, a plus-ended motor that regulates the polymerization and stability of cytoplasmic microtubules (cMTs). Kip2p levels are regulated during the cell cycle and its overexpression leads to the formation of hyper-elongated cMTs. To investigate the significance of varying Kip2p levels during the cell cycle and the hyper-elongated cMTs, we overexpressed KIP2 in G1 phase and examined the effects on the separation of spindle pole bodies (SPBs) and chromosome segregation...
May 8, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29739629/phenotypic-characteristics-of-a-french-cohort-of-patients-with-x-linked-retinoschisis
#8
Raphaëlle Orès, Saddek Mohand-Said, Claire-Marie Dhaenens, Aline Antonio, Christina Zeitz, Edouard Augstburger, Camille Andrieu, José-Alain Sahel, Isabelle Audo
PURPOSE: To analyze the retinal structure in patients with X-linked retinoschisis (XLRS) using spectral-domain OCT and to correlate the morphologic findings with visual acuity, electroretinographic results, and patient age. DESIGN: Retrospective, observational study. PARTICIPANTS: Data from 52 consecutive male patients with molecularly confirmed XLRS were collected retrospectively. METHODS: Complete clinical evaluation included best-corrected visual acuity, full-field electroretinography, fundus photography, spectral-domain OCT, and fundus autofluorescence...
May 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29738569/intraretinal-changes-in-idiopathic-versus-diabetic-epiretinal-membranes-after-macular-peeling
#9
Mario R Romano, Gennaro Ilardi, Mariantonia Ferrara, Gilda Cennamo, Davide Allegrini, Pia Pafundi, Ciro Costagliola, Stefania Staibano, Giovanni Cennamo
INTRODUCTION: Epiretinal traction is not responsible only for epiretinal but also intraretinal changes. This study aims to describe structural and vascular intraretinal changes after macular peeling in idiopathic (iERM) vs diabetic ERM (dERM). METHODS: We conducted a prospective interventional study on forty-two eyes, 23 with iERMs and 19 with dERMs, undergoing ERM-ILM peeling. We performed SD-OCT preoperatively, 1 and 6 months postoperatively to assess central macular thickness (CMT), intraretinal cysts (IC) and/or continuous ectopic inner foveal layers (CEIFL), superficial and deep capillary free zone (CFZ) area on OCT-A...
2018: PloS One
https://www.readbyqxmd.com/read/29735320/intravitreal-aflibercept-therapy-in-eyes-with-chronic-central-serous-chorioretihopathy-short-term-results
#10
K Tekin, P Cakar Ozdal, B Gulpamuk, M Yasin Teke
OBJECTIVES: To evaluate the short term efficacy and tolerability results of intravitreal aflibercept injection as a treatment option for eyes with chronic central serous chorioretinopathy (CSCR). MATERIAL AND METHODS: A prospective longitudinal study. Ten eyes of 10 patients with chronic CSCR who had been followed for >6months after the first intravitreal injection of aflibercept were recruited for the study. The best corrected visual acuity (BCVA) and central macular thickness (CMT) values obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the injection...
May 4, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29734122/reference-1d-and-2d-electrophoresis-maps-for-potential-disease-related-proteins-in-milk-whey-from-lactating-buffaloes-and-blood-serum-from-buffalo-calves-water-buffalo-bubalus-bubalis
#11
André M Santana, Funmilola C Thomas, Daniela G Silva, Eilidh McCulloch, Ana M C Vidal, Richard J S Burchmore, José J Fagliari, Peter D Eckersall
The aim of this study was to identify potential disease related proteins in milk whey of lactating buffaloes and blood serum of buffalo calves, in order to define a reference electrophoresis map for 1-DE and 2-DE. Additionally, changes in some protein patterns from buffalo calves during salmonellosis and lactating buffaloes during mastitis are presented. Milk samples were collected and distributed into groups: Milk samples from healthy buffaloes (SCC < 100.000 cells/ml, negative microbiology and CMT) (G1, n = 5) and buffaloes with subclinical mastitis (SCC > 500...
April 26, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29729827/association-of-mir-149-polymorphism-with-onset-age-and-severity-in-charcot-marie-tooth-disease-type-1a
#12
Soo Hyun Nam, Sumaira Kanwal, Da Eun Nam, Min Hee Lee, Tae Hoon Kang, Sung-Chul Jung, Byung-Ok Choi, Ki Wha Chung
Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by 1.5-fold increased dosage of the PMP22; however, onset age and severity vary considerably among patients. The exact reason behind these phenotypic heterogeneities has rarely been discovered yet. Because miRNAs are the key regulators of gene expression, we speculated that variants of miRNAs might be the genetic modifiers for CMT1A. This study noticed a common single nucleotide polymorphism (n.86T > C, rs2292832) in the miR-149 which was predicted to target several CMT causing genes including PMP22...
April 11, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29729594/motor-unit-number-index-correlates-with-disability-in-charcot-marie-tooth-disease
#13
Joachim Bas, Emilien Delmont, Farzad Fatehi, Emmanuelle Salort-Campana, Annie Verschueren, Jean Pouget, Marie-Noëlle Lefebvre, Aude-Marie Grapperon, Shahram Attarian
OBJECTIVE: The aim of this study was to assess the usefulness of motor unit number index (MUNIX) technique in Charcot-Marie-Tooth disease and test the correlation between MUNIX and clinical impairment. METHODS: MUNIX technique was performed in the abductor pollicis brevis (APB), the abductor digiti minimi (ADM) and the tibialis anterior (TA) muscles in the nondominant side. A MUNIX sum score was calculated by adding the MUNIX of these 3 muscles. Muscle strength was measured using the MRC (medical research council) scale...
April 16, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29720210/endoscopic-release-of-congenital-muscular-torticollis-with-radiofrequency-in-teenagers
#14
Jun-Liang Wang, Wei Qi, Yu-Jie Liu
BACKGROUND: Congenital muscular torticollis (CMT) is due to contracture of the sternocleidomastoid muscle which may cause activity limitations of the neck, tilt of the head, craniofacial asymmetry, and deformity of the skull. The authors present their experience of arthroscopic tight fibrous band release with radiofrequency in teenagers under local anesthesia and evaluate the clinical results. METHODS: A total of 69 patients who underwent arthroscopic release of CMT with radiofrequency under local anesthesia by a single surgeon could participate in this study...
May 3, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29718187/mutations-in-coa7-cause-spinocerebellar-ataxia-with-axonal-neuropathy
#15
Yujiro Higuchi, Ryuta Okunushi, Taichi Hara, Akihiro Hashiguchi, Junhui Yuan, Akiko Yoshimura, Kei Murayama, Akira Ohtake, Masahiro Ando, Yu Hiramatsu, Satoshi Ishihara, Hajime Tanabe, Yuji Okamoto, Eiji Matsuura, Takehiro Ueda, Tatsushi Toda, Sumimasa Yamashita, Kenichiro Yamada, Takashi Koide, Hiroaki Yaguchi, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Koichiro Doi, Shinichi Morishita, Ken Sato, Masanori Nakagawa, Masamitsu Yamaguchi, Shoji Tsuji, Hiroshi Takashima
Several genes related to mitochondrial functions have been identified as causative genes of neuropathy or ataxia. Cytochrome c oxidase assembly factor 7 (COA7) may have a role in assembling mitochondrial respiratory chain complexes that function in oxidative phosphorylation. Here we identified four unrelated patients with recessive mutations in COA7 among a Japanese case series of 1396 patients with Charcot-Marie-Tooth disease (CMT) or other inherited peripheral neuropathies, including complex forms of CMT...
April 27, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29715111/chemotherapy-or-combined-modality-therapy-for-early-stage-hodgkin-lymphoma
#16
Jordan A Torok, Yuan Wu, Junzo Chino, Leonard R Prosnitz, Anne W Beaven, Grace J Kim, Chris R Kelsey
BACKGROUND/AIM: Optimizing treatment of early-stage Hodgkin lymphoma (HL) requires balancing cure with potential acute and late toxicities from treatment. We reviewed our institutional experience with chemotherapy alone (ChT) versus combined modality therapy (CMT). MATERIALS AND METHODS: Patients with stage I-II classical HL in a complete response (CR) by functional imaging after chemotherapy were included. Progression-free survival (PFS) and overall survival (OS) were calculated and a multivariate analysis (MVA) was performed...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29715103/bidirectional-regulation-of-cox-2-expression-between-cancer-cells-and-macrophages
#17
Maria Isabel Carvalho, Rodolfo Bianchini, Judit Fazekas-Singer, Ina Herrmann, Irene Flickinger, Johann G Thalhammer, Isabel Pires, Erika Jensen-Jarolim, Felisbina L Queiroga
BACKGROUND/AIM: Our aim was to investigate the crosstalk between tumor and immune cells (M2 macrophages) and its effects on cyclo-oxygenase-2 (COX2) regulation in canine mammary tumors (CMT). MATERIALS AND METHODS: Sh1b CMT cells and human BT474 mammary or HT29 colon cancer cells were co-cultured with canine peripheral blood mononuclear cells (PBMCs) or with macrophage-like differentiated THP1 monocytes (dTHP1). Intracellular COX2 expression by PBMCs, dTHP1 and cancer cells was evaluated by flow cytometry...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29708803/a-5-year-follow-up-study-of-the-treatment-of-macular-edema-due-to-retinal-vein-occlusion-using-dexamethasone-intravitreal-implants
#18
Gonzaga Garay-Aramburu, Ángela Gómez-Moreno
PURPOSE: To evaluate the long-term effects of intravitreal dexamethasone implants (IDIs) in eyes with macular edema (ME) due to retinal vein occlusion (RVO). METHODS: We reviewed the records of 10 patients followed for 5 years after they received their first IDI. The main outcome measures included changes in best corrected visual acuity (BCVA), central macular thickness (CMT), and central macular volume (CMV), and the incidence of side effects. RESULTS: Ten patients were included in the study with a mean follow-up of 65...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29707774/early-stage-hodgkin-lymphoma-in-the-modern-era-simulation-modelling-to-delineate-long-term-patient-outcomes
#19
Susan K Parsons, Michael J Kelly, Joshua T Cohen, Sharon M Castellino, Tara O Henderson, Kara M Kelly, Frank G Keller, Tobi J Henzer, Anita J Kumar, Peter Johnson, Ralph M Meyer, John Radford, John Raemaekers, David C Hodgson, Andrew M Evens
We developed a novel simulation model integrating multiple data sets to project long-term outcomes with contemporary therapy for early-stage Hodgkin lymphoma (ESHL), namely combined modality therapy (CMT) versus chemotherapy alone (CA) via 18 F-fluorodeoxyglucose positron emission tomography response-adaption. The model incorporated 3-year progression-free survival (PFS), probability of cure with/without relapse, frequency of severe late effects (LEs), and 35-year probability of LEs. Furthermore, we generated estimates for quality-adjusted life years (QALYs) and unadjusted survival (life years, LY) and used model projections to compare outcomes for CMTversusCA for two index patients...
April 29, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29706600/retrospective-cohort-study-exploring-whether-an-association-exists-between-spatial-distribution-of-cystoid-spaces-in-cystoid-macular-oedema-secondary-to-retinitis-pigmentosa-and-response-to-treatment-with-carbonic-anhydrase-inhibitors
#20
Stacey A Strong, Nashila Hirji, Ana Quartilho, Angelos Kalitzeos, Michel Michaelides
BACKGROUND: Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists...
April 29, 2018: British Journal of Ophthalmology
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