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https://www.readbyqxmd.com/read/28924357/developmental-dysplasia-of-the-hip-do-the-responsible-for-screening-know-what-to-do
#1
Bruno Gonçalves Schröder E Souza, Tiago Evangelista de Melo, Thiago Mattos Resende, Rafaela Clara Resende da Silva, Soraya Amanda Cruz, Valdeci Manoel de Oliveira
OBJECTIVE: To evaluate the knowledge on developmental dysplasia of the hip (DDH) by professionals involved in its diagnosis. METHODS: This is a cross-sectional study using questionnaires to assess the knowledge about DDH. Orthopedic surgeons and pediatricians, residents and medical students from a tertiary teaching hospital were included in the study. RESULTS: We evaluated 142 medical students, eight orthopedic residents, ten pediatric residents, seven pediatricians, and nine orthopedic surgeons; 50% declared not having examined any DDH case in the last year and only three had diagnosed more than 10 cases during their career...
November 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28913517/intravitreal-injection-of-ziv-aflibercept-in-the-treatment-of-choroidal-and-retinal-vascular-diseases
#2
Kamran HodjatJalali, Shiva Mehravaran, Hooshang Faghihi, Hassan Hashemi, Pegah Kazemi, Hadith Rastad
PURPOSE: To investigate the short-term outcomes after intravitreal injection of ziv-aflibercept in the treatment of choroidal and retinal vascular diseases. METHODS: Thirty-four eyes of 29 patients with age-related macular degeneration (AMD), diabetic retinopathy, and retinal vein occlusion (RVO) received a single dose intravitreal injection of 0.05 ml ziv-aflibercept (1.25 mg). Visual acuity, spectral domain optical coherence tomography (SD-OCT) activity, and possible side effects were assessed before and at 1 week and 1 month after the intervention...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28912967/correlation-of-macular-focal-electroretinogram-with-ellipsoid-zone-extension-in-stargardt-disease
#3
Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini
Stargardt disease (STGD1) is the most common cause of inherited juvenile macular degeneration. This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium. The aim of this study was to evaluate the relationship between cone photoreceptor function and structure in STGD1. Macular function was assessed by visual acuity measurement and focal electroretinogram (FERG) recording while spectral domain optical coherence tomography (SD-OCT) imaging was performed to evaluate the integrity of photoreceptors...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903872/prevalence-of-subclinical-mastitis-and-associated-risk-factors-at-cow-and-herd-level-in-dairy-farms-in-north-west-ethiopia
#4
S A Mekonnen, G Koop, S T Melkie, C D Getahun, H Hogeveen, T J G M Lam
Knowledge of mastitis pathogens and their predominance as well as understanding of risk factors are prerequisites to improve udder health in a herd, region or country. In Ethiopia, such information is scarce, despite the fact that mastitis is an important cattle disease in the country. A cross-sectional study that describes prevalence and causative agents of subclinical mastitis (SCM) as well as risk factors at cow and herd level was conducted on 167 dairy farms in North-West Ethiopia. On average, 33% of the quarters and 62% of the cows were California Mastitis Test (CMT) positive, but the within herd quarter level prevalence ranged between 0 and 100%...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28902332/high-dose-decanted-triamcinolone-for-treatment-resistant-persistent-macular-edema
#5
Ilkay Kilic Muftuoglu, Frank F Tsai, Tiezhu Lin, William R Freeman
BACKGROUND AND OBJECTIVE: To report the outcomes of decanted high-dose intravitreal triamcinolone acetonide (HD-IVTA) injection for treatment-resistant persistent macular edema (ME). PATIENTS AND METHODS: Seventy-seven eyes of 70 consecutive patients who failed prior treatments for persistent ME received as-needed HD-IVTA injections. Best-corrected visual acuity and central macular thickness (CMT) were assessed at all follow-up visits. RESULTS: Thirty-three eyes (42...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28898873/two-year-outcomes-of-a-treat-and-extend-regimen-using-intravitreal-aflibercept-injections-for-typical-age-related-macular-degeneration
#6
Arisa Ito, Hidetaka Matsumoto, Masahiro Morimoto, Kensuke Mimura, Hideo Akiyama
PURPOSE: The aim of this study was to evaluate the efficacy of a treat-and-extend (TAE) regimen using intravitreal injection of aflibercept (IVA) for typical age-related macular degeneration (tAMD). METHODS: We retrospectively studied 61 treatment-naïve eyes with tAMD. Best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), number of injections, and complications during 2 years were evaluated. RESULTS: BCVA significantly improved by on average 0...
September 13, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28887113/primary-month-6-outcomes-of-the-stop-uveitis-study-evaluating-the-safety-tolerability-and-efficacy-of-tocilizumab-in-patients-with-non-infectious-uveitis
#7
Yasir Jamal Sepah, Mohammad Ali Sadiq, David S Chu, Mark Dacey, Ron Gallemore, Pouya Dayani, Mostafa Hanout, Muhammad Hassan, Rubbia Afridi, Aniruddha Agarwal, Muhammad Sohail Halim, Diana V Do, Quan Dong Nguyen
PURPOSE: To report the primary end-point analyses of the safety and efficacy of two different doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with non-infectious intermediate, posterior or pan-uveitis. DESIGN: Randomized, controlled, multicenter clinical trial. METHODS: STOP-Uveitis is a randomized, open-label safety, efficacy and bioactivity clinical trial conducted at 5 clinical centers across the United States...
September 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28869485/nerve-conduction-studies-as-a-measure-of-disease-progression-objectivity-or-illusion
#8
Giuseppe Lanza, Ana Kosac, Goran Trajkovic, Roger G Whittaker
BACKGROUND: Clinical nerve conduction studies (NCS) are often used as a secondary outcome measure in therapeutic trials, but show a high degree of inter-trial variability even when technical factors known to affect the recorded responses are minimised. This raises the intriguing possibility that some of the observed variability may reflect true changes in nerve activity. OBJECTIVES: Our aim was determine how much variability these factors might produce, and how this might affect the results of commonly used neuropathy rating scales...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28860329/biomarkers-predict-outcome-in-charcot-marie-tooth-disease-1a
#9
Robert Fledrich, Manoj Mannil, Andreas Leha, Caroline Ehbrecht, Alessandra Solari, Ana L Pelayo-Negro, José Berciano, Beate Schlotter-Weigel, Tuuli J Schnizer, Thomas Prukop, Natalia Garcia-Angarita, Dirk Czesnik, Jana Haberlová, Radim Mazanec, Walter Paulus, Tim Beissbarth, Maggie C Walter, Cmt- Triaal, Jean-Yves Hogrel, Odile Dubourg, Angelo Schenone, Jonathan Baets, Peter De Jonghe, Michael E Shy, Rita Horvath, Davide Pareyson, Pavel Seeman, Peter Young, Michael W Sereda
BACKGROUND: Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited neuropathy, a debilitating disease without known cure. Among patients with CMT1A, disease manifestation, progression and severity are strikingly variable, which poses major challenges for the development of new therapies. Hence, there is a strong need for sensitive outcome measures such as disease and progression biomarkers, which would add powerful tools to monitor therapeutic effects in CMT1A. METHODS: We established a pan-European and American consortium comprising nine clinical centres including 311 patients with CMT1A in total...
August 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28859335/a-new-mutation-in-fig4-causes-a-severe-form-of-cmt4j-involving-trpv4-in-the-pathogenic-cascade
#10
Benoit J Gentil, Erin O'Ferrall, Colin Chalk, Luis F Santana, Heather D Durham, Rami Massie
Mutations in FIG4, coding for a phosphoinositol(3,5) bisphosphate 5' phosphatase and involved in vesicular trafficking and fusion, have been shown causing a recessive form of Charcot-Marie-Tooth (CMT). We have identified a novel intronic mutation in the FIG4 in a wheel-chair bound patient presenting with a severe form of CMT4J and provide a longitudinal study. Investigations indicated a demyelinating sensorimotor polyneuropathy with diffuse active denervation and severe axonal loss. Genetic testing revealed that the patient is heterozygous for 2 FIG4 mutations, p...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28853535/intravitreal-dexamethasone-implant-as-an-adjunct-weapon-for-severe-and-refractory-uveitis-in-beh%C3%A3-et-s-disease
#11
Claudia Fabiani, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Gian Marco Tosi, Donato Rigante, Luca Cantarini
BACKGROUND: The evidence on the use of dexamethasone implants in the treatment of Behçet's disease (BD)-related uveitis is limited to a few cases. OBJECTIVES: To evaluate the efficacy of dexamethasone implants on ocular functional, morphological, and clinical parameters in BD patients with severe refractory uveitis. METHODS: Five eyes from five BD patients were enrolled. A single intravitreal dexamethasone injection was applied to each eye...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28853395/polo-like-kinase-cdc5-regulates-spc72-recruitment-to-spindle-pole-body-in-the-methylotrophic-yeast-ogataea-polymorpha
#12
Hiromi Maekawa, Annett Neuner, Diana Rüthnick, Elmar Schiebel, Gislene Pereira, Yoshinobu Kaneko
Cytoplasmic microtubules (cMT) control mitotic spindle positioning in many organisms, and are therefore pivotal for successful cell division. Despite its importance, the temporal control of cMT formation remains poorly understood. Here we show that unlike the best-studied yeast Saccharomyces cerevisiae, position of pre-anaphase nucleus is not strongly biased toward bud neck in Ogataea polymorpha and the regulation of spindle positioning becomes active only shortly before anaphase. This is likely due to the unstable property of cMTs compared to those in S...
August 30, 2017: ELife
https://www.readbyqxmd.com/read/28852904/-what-should-i-inject-next-challenging-treatment-decisions-in-the-multiple-anti-vegf-a-review-of-publications-exploring-anti-vegf-switching-for-namd
#13
Joseph Pikkel, Shira Attas
PURPOSE: The purpose of our work was to collate information from studies published to date focusing on switching in anti-VEGF therapy and describe the currently available data on anti-VEGF switching in nAMD. METHODS: A PubMed search of published articles from January 2010 to January 2017 was conducted. Published studies were compared in parameters of sample size, reason for switch, duration of follow-up, and switch outcome (functional and anatomical). RESULTS: Our search revealed 31 relevant publications...
August 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28846509/reliability-and-validity-of-the-interpersonal-guilt-rating-scale-15-a-new-clinician-reporting-tool-for-assessing-interpersonal-guilt-according-to-control-mastery-theory
#14
Francesco Gazzillo, Bernard Gorman, Marshall Bush, George Silberschatz, Cristina Mazza, Filippo Faccini, Valeria Crisafulli, Roberta Alesiani, Emma De Luca
This article introduces the Interpersonal Guilt Rating Scale-15 (IGRS-15), a brief clinician-rated tool for the clinical assessment of interpersonal guilt as conceived in Control-Mastery Theory (CMT; Silberschatz, 2015; Weiss, 1993), and its psychometric proprieties. The items of the IGRS-15 were derived from the CMT clinical and empirical literature about guilt, and from the authors' clinical experiences. Twenty-eight clinicians assessed 154 patients with the IGRS-15, the patient self-reported Interpersonal Guilt Questionnaire-67 (IGQ-67; O'Connor, Berry, Weiss, Bush, & Sampson, 1997), and the Clinical Data Form (CDF; Westen & Shedler, 1999)...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/28846119/detection-of-early-loss-of-color-vision-in-age-related-macular-degeneration-with-emphasis-on-drusen-and-reticular-pseudodrusen
#15
Roopa Vemala, Sobha Sivaprasad, John L Barbur
Purpose: To evaluate chromatic sensitivity in patients with age-related macular degeneration (AMD) characterized by drusen and reticular pseudodrusen. To investigate whether the severity of color vision loss can distinguish between various stages of AMD and hence be used as an index of progression toward advanced AMD. Methods: Chromatic sensitivity was measured by using the Color Assessment and Diagnosis (CAD) test in asymptomatic individuals with early and intermediate AMD and compared to normative data...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28844614/responsiveness-of-gait-analysis-parameters-in-a-cohort-of-71-cmt-subjects
#16
Tiziana Lencioni, Giuseppe Piscosquito, Marco Rabuffetti, Gabriele Bovi, Enrica Di Sipio, Manuela Diverio, Isabella Moroni, Luca Padua, Emanuela Pagliano, Angelo Schenone, Davide Pareyson, Maurizio Ferrarin
Detection of worsening in the slowly progressive Charcot-Marie-Tooth disease (CMT) is difficult. As previous clinical scales showed low responsiveness, novel outcome measures are under study, including innovative approaches such as quantitative muscle MRI and instrumented movement analysis. Since gait analysis proved able to reliably quantify CMT locomotor deficits, we aimed to explore whether it can be a sensitive-to-change outcome measure in CMT studies. Clinical and biomechanical evaluations were performed in 71 CMT subjects at baseline and after a mean (±sd) of 28...
July 14, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28841859/a-gja9-frameshift-variant-is-associated-with-polyneuropathy-in-leonberger-dogs
#17
Doreen Becker, Katie M Minor, Anna Letko, Kari J Ekenstedt, Vidhya Jagannathan, Tosso Leeb, G Diane Shelton, James R Mickelson, Cord Drögemüller
BACKGROUND: Many inherited polyneuropathies (PN) observed in dogs have clinical similarities to the genetically heterogeneous group of Charcot-Marie-Tooth (CMT) peripheral neuropathies in humans. The canine disorders collectively show a variable expression of progressive clinical signs and ages of onset, and different breed prevalences. Previously in the Leonberger breed, a variant highly associated with a juvenile-onset PN was identified in the canine orthologue of a CMT-associated gene...
August 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28841801/glioblastoma-in-the-elderly-initial-management
#18
Fabio Ynoe de Moraes, Normand Laperriere
Glioblastoma is the most common primary CNS malignancy and it is becoming more frequently diagnosed in the elderly population. Glioblastoma is associated with a dismal prognosis and remains a huge challenge for the neuro-oncology community. Surgical resection/biopsy is well defined as an important first approach in the care of this disease, for tumor diagnosis, molecular analysis and maximum resection. MGMT promoter methylation status has proved to be a useful indicator of whether single modality (RT or TMZ alone) or combined modality treatment may achieve better outcomes...
August 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28840969/intraprostatic-botulinum-toxin-type-a-injection-in-patients-with-benign-prostatic-hyperplasia-and-unsatisfactory-response-to-medical-therapy-a-randomized-double-blind-controlled-trial-using-urodynamic-evaluation
#19
Angelo Totaro, Francesco Pinto, Dario Pugliese, Matteo Vittori, Marco Racioppi, Nazario Foschi, Pier Francesco Bassi, Emilio Sacco
AIMS: The injection of botulinum neurotoxin A (BTA) into the prostate represents a minimally invasive treatment in patients with lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH). We evaluated the effectiveness of BTA in treating patients with BPH unresponsive to combined medical therapy (CMT), using urodynamic investigations. METHODS: This is a randomized, placebo-controlled, double blind trial. Twenty consecutive patients were randomly assigned to receive intraprostatic BTA injection (n = 10) or saline solution (SS) (n = 10)...
August 25, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28839510/combined-intravitreal-dexamethasone-implant-and-micropulse-yellow-laser-for-treatment-of-anti-vegf-resistant-diabetic-macular-edema
#20
Ahmed Hosni Abd Elhamid
PURPOSE: To report the efficacy and safety of combined intravitreal dexamethasone implant and micropulse laser for anti-VEGF resistant diabetic macular edema. PATIENTS AND METHODS: Prospective, non-controlled study that was conducted for twenty eyes with center-involved diabetic macular edema not responding to anti-VEGF therapy. Ozurdex intravitreal implant was injected to all eyes with subsequent micropulse yellow laser one month after the injection. All eyes were followed up after one, three, four, six, nine and twelve months...
2017: Open Ophthalmology Journal
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