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https://www.readbyqxmd.com/read/28441077/comparison-of-conbercept-with-ranibizumab-for-the-treatment-of-macular-edema-secondary-to-branch-retinal-vein-occlusion
#1
Fengjiao Li, Ming Sun, Jianlian Guo, Aihua Ma, Bojun Zhao
PURPOSE: To confirm the therapeutic efficacy of conbercept for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: In this prospective, randomized, and comparative study, patients were randomized and divided into conbercept (n = 18) and ranibizumab (n = 17) groups. After an initial intravitreal injection of either conbercept or ranibizumab, a pro re nata (PRN) strategy was adopted based on loss of visual acuity (VA) or increase in central macular thickness (CMT)...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28438772/severe-vincristine-induced-polyneuropathy-in-a-teenager-with-anaplastic-medulloblastoma-and-undiagnosed-charcot-marie-tooth-disease
#2
Yasmin Aghajan, Janet M Yoon, John Ross Crawford
Severe neuropathy is a known adverse effect of vincristine in patients with Charcot-Marie-Tooth disease (CMT). We present the case of a 16-year-old girl with anaplastic medulloblastoma treated with gross total resection and high-dose craniospinal radiation with adjuvant vincristine chemotherapy who developed acute-onset severe quadriplegia and vocal cord paralysis. Vincristine and radiation therapy were discontinued. Although her neuropathy slowly improved over several weeks, she developed metastatic extraneural medulloblastoma and died 5 months after diagnosis...
April 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28435201/association-of-claw-disorders-with-subclinical-intramammary-infections-in-egyptian-dairy-cows
#3
Walid Refaai, Medhat Gad, Yasser Mahmmod
AIM: Bovine mastitis and lameness are the most common production diseases affecting dairy farms worldwide resulting in huge economic impact and impaired animal welfare. The objective of this field study was to investigate the association of infectious and non-infectious claw disorders with the occurrence of subclinical intramammary infections (IMIs) diagnosed by California mastitis test (CMT) in dairy cows under Egyptian conditions. MATERIALS AND METHODS: A total of 43 dairy cows were included in this field study...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28432109/early-response-to-ranibizumab-predictive-of-functional-outcome-after-dexamethasone-for-unresponsive-diabetic-macular-oedema
#4
Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyse the effects of intravitreal dexamethasone implant in patients suffering from diabetic macular oedema (DME) on the basis of their visual and functional response to antivascular endothelial growth factor (VEGF) loading dose, in order to early shift to corticosteroids in poorly responding patients. DESIGN: Retrospective monocentric study. METHODS: Data of patients with diabetes shifted to 0.7 mg dexamethasone implant after three injections of ranibizumab (RNB) and followed-up to 12 months were reviewed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28426622/changes-in-central-choroidal-thickness-after-treatment-of-diabetic-macular-edema-with-intravitreal-bevacizumab-correlation-with-central-macular-thickness-and-best-corrected-visual-acuity
#5
Ramin Nourinia, Hamid Ahmadieh, Elnaz Nekoei, Parviz Malekifar, Zahra Tofighi
PURPOSE: To assess the effect of intravitreal injection of bevacizumab on central choroidal thickness (CCT) and its relationship with central macular thickness (CMT) and best-corrected visual acuity (BCVA) changes in eyes with center-involving diabetic macular edema. METHODS: This prospective interventional case series included 20 eyes of 20 patients with center-involving diabetic macular edema naive to treatment. The BCVA assessment, complete eye examination, enhanced depth optical coherence tomography, and fluorescein angiography were performed at baseline followed by 3 monthly intravitreal injection of bevacizumab...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28422832/two-year-result-of-intravitreal-bevacizumab-for-diabetic-macular-edema-using-treat-and-extend-protocol
#6
Masahiko Sugimoto, Atsushi Ichio, Takayasu Nunome, Mineo Kondo
To determine the efficacy of the treat and extend (TAE) protocol with intravitreal bevacizumab (IVB) for managing diabetic macular edema (DME).Retrospective, single-center study.For this retrospective study, 42 eyes of 42 patients were initially treated with 3 consecutive monthly IVB injections (loading phase), after which they were selected for different additional therapies. For the TAE protocol, the baseline treatment interval was selected to be 8 weeks and was sequentially lengthened by 2 weeks if the central macular thickness (CMT) was <300 μm at 2 consecutive examinations...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28419397/influence-of-retinal-pathology-on-the-reliability-of-macular-thickness-measurement-a-comparison-between-optical-coherence-tomography-devices
#7
Bobak Bahrami, Shaun Y P Ewe, Thomas Hong, Meidong Zhu, Germane Ong, Kehui Luo, Andrew Chang
BACKGROUND AND OBJECTIVE: To evaluate the repeatability, reliability, and comparability of macular thickness measurements between three optical coherence tomography (OCT) machines in healthy eyes, eyes with diabetic macular edema (DME), and eyes with neovascular age-related macular degeneration (nAMD). PATIENTS AND METHODS: Twenty-three eyes with DME, 26 eyes with nAMD, and 24 healthy eyes as controls were evaluated. Scans were performed using the swept-source Triton (Topcon, Tokyo, Japan), the spectral-domain Cirrus (Carl Zeiss Meditec, Dublin, CA), and the Spectralis (Heidelberg Engineering, Heidelberg, Germany) machines...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28419387/effect-of-continuous-positive-airway-pressure-treatment-on-health-related-quality-of-life-and-sleepiness-in-high-cardiovascular-risk-individuals-with-sleep-apnea-best-apnea-interventions-for-research-bestair-trial
#8
Ying Y Zhao, Rui Wang, Kevin J Gleason, Eldrin F Lewis, Stuart F Quan, Claudia M Toth, Michael Morrical, Michael Rueschman, Jia Weng, James H Ware, Murray A Mittleman, Susan Redline
Study Objectives: The long term effect of continuous positive airway pressure (CPAP) on health-related quality of life (HRQOL) in patients with high cardiovascular disease risk and obstructive sleep apnea (OSA) without severe sleepiness is uncertain. We aimed to determine the effect of CPAP treatment on HRQOL in individuals with moderate or severe OSA and cardiovascular disease (CVD) or multiple CVD risk factors without severe sleepiness. Methods: In this randomized, controlled, parallel group study, 169 participants were assigned to treatment with CPAP or the control group (conservative medical therapy [CMT] or CMT with sham CPAP)...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28414561/interferon-alpha-for-the-treatment-of-cystoid-macular-edema-associated-with-presumed-ocular-tuberculosis
#9
Merih Oray, Sumru Onal, Gunay Uludag, Aylin Koc Akbay, Ilknur Tugal-Tutkun
PURPOSE: To report the efficacy and safety of interferon (IFN) α-2a in patients with cystoid macular edema (CME) associated with presumed ocular tuberculosis (TB). METHODS: We reviewed the clinical records of 5 patients with presumed ocular TB who had been treated with IFN α-2a for recurrent CME during or after completion of anti-tubercular therapy. IFN α-2a was administered at an initial dose of 3 million IU per day and then tapered after the initial response...
April 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28413319/black-ginseng-enriched-chong-myung-tang-extracts-improve-spatial-learning-behavior-in-rats-and-elicit-anti-inflammatory-effects-in%C3%A2-vitro
#10
Evelyn Saba, Da-Hye Jeong, Seong-Soo Roh, Seung-Hyung Kim, Sung-Dae Kim, Hyun-Kyoung Kim, Man-Hee Rhee
BACKGROUND: Chong-Myung-Tang (CMT) extract is widely used in Korea as a traditional herbal tonic for increasing memory capacity in high-school students and also for numerous body ailments since centuries. The use of CMT to improve the learning capacity has been attributed to various plant constituents, especially black ginseng, in it. Therefore, in this study, we have first investigated whether black ginseng-enriched CMT extracts affected spatial learning using the Morris water maze (MWM) test...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28400656/congenital-muscular-torticollis-use-of-gaze-angle-and-translational-deformity-in-assessment-of-facial-asymmetry
#11
Atul Bhaskar, U Harish, Hardik Desai
BACKGROUND: Assessment of facial asymmetry is challenging in torticollis deformity. Neck tilt in toroticollis is associated with deviation of horizontal ocular gaze and translation of neck from the midline. These deviations can be assessed clinically and can be used as surrogate marker for facial asymmetry. MATERIALS AND METHODS: Thirty five children with congenital muscular torticollis (CMT) were classified into three grades of severity based on the new clinical score...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28393034/intravitreal-aflibercept-in-neovascular-age-related-macular-degeneration-previously-treated-with-ranibizumab
#12
Rachel Hui Fen Lim, Bhaskar Gupta, Peter Simcock
AIM: To report the change in visual acuity and central macular thickness (CMT) following treatment with intravitreal aflibercept injections in patients with neovascular age-related macular degeneration (nAMD) with suboptimum response to ranibizumab. METHODS: This was a retrospective study. The inclusion criteria were patients with nAMD who responded poorly to ranibizumab. Patients then received either 3 consecutive aflibercept injections followed by pro re nata (PRN) treatment or PRN alone...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28388263/reversal-of-cystoid-macular-edema-in-gyrate-atrophy-patients
#13
Dan Heller, Chen Weiner, Iris Nasie, Yair Anikster, Yuval Landau, Tal Koren, Russell Pokroy, Adi Abulafia, Eran Pras
PURPOSE: This study reports the presentation of two families with gyrate atrophy (GA). The aim of this study was to characterize the potential effect of therapeutic regimens on macular edema. METHODS: Two unrelated patients with GA were studied for the potential effect of low protein diet (≤ 0.8 g/kg/d), and oral administration of pyridoxine (500 mg/day), on serum ornithine levels, best corrected visual acuity (BCVA), slit-lamp, OCT, and auto-fluorescence findings...
April 7, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28386700/clinical-efficacy-of-anti-vegf-medications-for-central-serous-chorioretinopathy-a-meta-analysis
#14
Shangli Ji, Yemei Wei, Jiansu Chen, Shibo Tang
Background Central serous chorioretinopathy (CSC) is a widespread retinal disorder, and 30-50% of patients eventually result in retinal pigment epithelium atrophy and irreversible vision loss. Aim of the review To evaluate the effectiveness of medications based on anti-vascular endothelial growth factor (anti-VEGF) on central serous chorioretinopathy (CSC). Method A systematic search on anti-VEGF medication treatments for CSC was performed in Pubmed, Embase, and the Cochrane Library prior to May 2016. The main outcome variables were best-corrected visual acuity (BCVA) and central macular thickness (CMT)...
April 6, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28380943/metamaterial-perfect-absorbers-with-solid-and-inverse-periodic-cross-structures-for-optoelectronic-applications
#15
Haochi Yu, Ziyi Zhao, Qinbai Qian, Jie Xu, Peng Gou, Yuexin Zou, Jun Cao, Le Yang, Jie Qian, Zhenghua An
Metamaterial based on a metal/insulator/metal (MIM) tri-layer structure provides an agile platform to realize high absorption efficiency for a variety of applications including semiconductor optoelectronic detectors. In this work, we use the finite time domain difference (FDTD) method and coupled mode theory (CMT) to numerically study metal/semiconductor/metal (MSM) structures and discuss their effective absorption for optoelectronic application. We compare MSM structures with a different top metal layer design and find that cross shaped absorber (CSA) and it's complementary cross shaped absorber (CCSA) exhibit different phase diagrams due to a distinctive dependence of radiation loss on geometrical parameters...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28379567/retinal-photoreceptor-functions-are-compromised-in-patients-with-resistance-to-thyroid-hormone-syndrome-rth%C3%AE
#16
Irene Campi, Gabriella Cammarata, Stefania Bianchi Marzoli, Paolo Beck-Peccoz, Diletta Santarsiero, Davide Dazzi, Alessandra Bottari de Castello, Elena Giuliana Taroni, Francesco Viola, Caterina Mian, Sara Watuntantrige-Fernando, Carla Pelusi, Marina Muzza, Maria Antonia Maffini, Luca Persani
CONTEXT: In animal models, disruption of thyroid hormone receptor-beta (TRβ) reduces the medium-wavelength (L/M) and increases the short-wavelength (S)-cones. The retinal photoreceptors (RPs) functions are unknown in patients with resistance to thyroid hormone syndrome with dominant-negative TRβ mutations (RTHβ). OBJECTIVE: to investigate RPs function in RTHβ. DESIGN, SETTING AND PARTICIPANTS: case-control study involving 27 RTHβ patients and 31 age-gender-matched controls, conducted in two tertiary referral centers in Italy...
March 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28379183/rapid-identification-of-pathogenic-variants-in-two-cases-of-charcot-marie-tooth-disease-by-gene-panel-sequencing
#17
Chi-Chun Ho, Shuk-Mui Tai, Edmond Chi-Nam Lee, Timothy Shin-Heng Mak, Timothy Kam-Tim Liu, Victor Wai-Lun Tang, Wing-Tat Poon
Charcot-Marie-Tooth disease (CMT) is a common inherited peripheral neuropathy affecting up to 1 in 1214 of the general population with more than 60 nuclear genes implicated in its pathogenesis. Traditional molecular diagnostic pathways based on relative prevalence and clinical phenotyping are limited by long turnaround time, population-specific prevalence of causative variants and inability to assess multiple co-existing variants. In this study, a CMT gene panel comprising 27 genes was used to uncover the pathogenic mutations in two index patients...
April 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28371924/implementation-of-a-quality-improvement-initiative-improved-congenital-muscular-torticollis-outcomes-in-a-large-hospital-setting
#18
Mariann L Strenk, Michelle Kiger, Jesse L Hawke, Amy Mischnick, Catherine Quatman-Yates
Background.: The American Physical Therapy Association (APTA) published a guideline for Congenital Muscular Torticollis (CMT) in 2013. Our division adopted the guideline as the institutional practice standard and engaged in a quality improvement (QI) initiative to increase the percentage of patients who achieved resolution of CMT within six months of evaluation. Objective.: The aims of this report are to describe the QI activities we conducted to improve patient outcomes and discuss the results and implications for other institutions and patient populations...
March 24, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28367202/effect-of-topical-nepafenac-in-prevention-of-macular-edema-after-cataract-surgery-in-patients-with-non-proliferative-diabetic-retinopathy
#19
Muhammad Haroon Sarfraz, Rana Intisar Ul Haq, Mohammad Asim Mehboob
OBJECTIVE: To determine the efficacy of topical Nepafenac (0.1%), administered post-operatively in prevention of Macular Edema (ME), after cataract surgery in patients with Non-Proliferative Diabetic Retinopathy (NPDR). METHODS: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from Sep 2015 to Sep 2016. Sixty eyes of 60 patients with NPDR underwent phacoemulsification with intraocular lens implantation. Group 1 received 0...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28367188/efficacy-of-intravitreal-bevacizumab-combined-with-pan-retinal-photocoagulation-versus-panretinal-photocoagulation-alone-in-treatment-of-proliferative-diabetic-retinopathy
#20
Murtaza Sameen, Muhammad Saim Khan, Ahsan Mukhtar, Muhammad Amer Yaqub, Mazhar Ishaq
OBJECTIVE: To compare effectiveness of pan-retinal photocoagulation alone versus panretinal photocoagulation combined with intravitreal bevacizumab on visual acuity and central macular thickness in patients presenting with proliferative diabetic retinopathy. METHODS: This Randomized controlled trial was carried out at Armed Forces Institute of ophthalmology, Pakistan from Jan 2016 to Aug 2016. Seventy six eyes of 50 patients having proliferative diabetic retinopathy and diabetic macular edema were included in the study...
January 2017: Pakistan Journal of Medical Sciences Quarterly
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