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https://www.readbyqxmd.com/read/28063734/safety-of-intravenous-iron-in-hemodialysis-longer-term-comparisons-of-iron-sucrose-versus-sodium-ferric-gluconate-complex
#1
Wolfgang C Winkelmayer, Benjamin A Goldstein, Aya A Mitani, Victoria Y Ding, Medha Airy, Sreedhar Mandayam, Tara I Chang, M Alan Brookhart, Steven Fishbane
BACKGROUND: Controversy exists about any differences in longer-term safety across different intravenous iron formulations routinely used in hemodialysis (HD) patients. We exploited a natural experiment to compare outcomes of patients initiating HD therapy in facilities that predominantly (in ≥90% of their patients) used iron sucrose versus sodium ferric gluconate complex. STUDY DESIGN: Retrospective cohort study of incident HD patients. SETTING & PARTICIPANTS: Using the US Renal Data System, we hard-matched on geographic region and center characteristics HD facilities predominantly using ferric gluconate with similar ones using iron sucrose...
January 4, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28052413/a-randomized-trial-of-iron-isomaltoside-versus-iron-sucrose-in-patients-with-iron-deficiency-anemia
#2
Richard Derman, Eloy Roman, Manuel R Modiano, Maureen M Okam, Lars L Thomsen, Michael Auerbach
Iron deficiency anemia (IDA) is common in many chronic diseases and intravenous (IV) iron offers a rapid and efficient iron correction. This trial compared the efficacy and safety of iron isomaltoside and iron sucrose in patients with IDA who were intolerant of, or unresponsive to, oral iron. The trial was an open-label, comparative, multi-center trial. 511 patients with IDA from different causes were randomized 2:1 to iron isomaltoside or iron sucrose and followed for 5 weeks. The cumulative dose of iron isomaltoside was based on body weight and hemoglobin (Hb), administered as either a 1000 mg infusion over more than 15 minutes or 500 mg injection over 2 minutes...
January 4, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28002754/iron-nanomedicines-induce-toll-like-receptor-activation-cytokine-production-and-complement-activation
#3
Johan J F Verhoef, A Marit de Groot, Marc van Moorsel, Jeffrey Ritsema, Nataliia Beztsinna, Coen Maas, Huub Schellekens
Approximately a dozen of intravenous iron nanomedicines gained marketing authorization in the last two decades. These products are generally considered as safe, but have been associated with an increased risk for hypersensitivity-like reactions of which the underlying mechanisms are unknown. We hypothesized that iron nanomedicines can trigger the innate immune system. We hereto investigated the physico-chemical properties of ferric gluconate, iron sucrose, ferric carboxymaltose and iron isomaltoside 1000 and comparatively studied their interaction with Toll-like receptors, the complement system and peripheral blood mononuclear cells...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/27994861/comparison-of-intravenous-low-molecular-weight-iron-dextran-and-intravenous-iron-sucrose-for-the-correction-of-anaemia-in-pre-dialysis-chronic-kidney-disease-patients-a-randomized-single-centre-study-in-nigeria
#4
Bala Waziri, Monica Mabayoje, Babawale Bello
BACKGROUND: Intravenous low molecular weight iron dextran and iron sucrose have been used for correction of iron deficiency for many years and have been shown to improve anaemia in chronic kidney disease (CKD). However, there is a paucity of head to head comparisons of these parenteral iron preparations. Such comparative efficacy data would be of particular interest in resource-limited African countries, where the majority of CKD patients are unable to afford erythropoiesis-stimulating agents...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27971344/cost-outcome-analysis-of-different-intravenous-iron-sucrose-preparations-in-hemodialysis-patients
#5
M Bourdoncle, D Sémély, C Porteils, S Oses, A Pagès, Labadens, M Parmier, B Juillart-Condat, A Del Bello
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27915456/use-of-iron-sucrose-and-red-blood-cell-transfusions-in-anaemic-cancer-patients-in-france-oncofer-study
#6
Elisabeth Luporsi, Alain Toledano, Dominique Spaeth, Florian Scotté, Marc Espié, Stéphanie Perot, Ladan Duvillié, Isabelle Pithois Merli, Roland Bugat
PURPOSE: This report describes the results of an observational, retrospective cohort study, evaluating the use of iron sucrose (IS) and red blood cell (RBC) transfusions in patients with cancer in routine clinical practice in France. A parallel investigated cohort treated with ferric carboxymaltose (FCM) has been reported earlier. METHODS: Data of patients with a solid tumour or haematological malignancy who have received IS or an RBC transfusion during 2010 from 3 months prior (M-3) to 3 months post first treatment (M+3) were analysed...
December 3, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27889746/distinct-in-vitro-complement-activation-by-various-intravenous-iron-preparations
#7
Julia Cordelia Hempel, Felix Poppelaars, Mariana Gaya da Costa, Casper F M Franssen, Thomas P G de Vlaam, Mohamed R Daha, Stefan P Berger, Marc A J Seelen, Carlo A J M Gaillard
BACKGROUND: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphylactic clinical picture known as complement activation-related pseudo allergy (CARPA). METHODS: First, the in-vitro complement-activating capacity was determined for 5 commonly used IV iron preparations using functional complement assays for the 3 pathways...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/27852236/effects-of-intravenous-iron-on-fibroblast-growth-factor-23-fgf23-in-haemodialysis-patients-a-randomized-controlled-trial
#8
Matthew A Roberts, Louis Huang, Darren Lee, Robert MacGinley, Stefanie M A Troster, Annette B Kent, Sukhvinder S Bansal, Iain C Macdougall, Lawrence P McMahon
BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function. We hypothesized that intravenous iron modulates iFGF23 and cFGF23 in haemodialysis patients differently according to the type of iron used. METHODS: Prevalent, stable haemodialysis patients requiring protocol-based intravenous iron therapy were randomized to a single 200 mg dose of either ferric carboxymaltose (FCM) or iron sucrose (IS)...
November 16, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27777125/dynamic-changes-of-isia-containing-complexes-during-long-term-iron-deficiency-in-synechocystis-sp-pcc-6803
#9
Fei Ma, Xin Zhang, Xi Zhu, Tianpei Li, Jiao Zhan, Hui Chen, Chenliu He, Qiang Wang
Iron stress-induced protein A (IsiA), a major chlorophyll-binding protein in the thylakoid membrane, is significantly induced under iron deficiency conditions. Using immunoblot analysis and 77 K fluorescence spectroscopy combined with sucrose gradient fractionation, we monitored dynamic changes of IsiA-containing complexes in Synechocystis sp. PCC 6803 during exposure to long-term iron deficiency. Within 3 days of exposure to iron deficiency conditions, the initially induced free IsiA proteins preferentially conjugated to PS I trimer to form IsiA18-PS I trimers, which serve as light energy collectors for efficiently transmitting energy to PS I...
January 9, 2017: Molecular Plant
https://www.readbyqxmd.com/read/27713040/tetrahydrocurcumin-in-combination-with-deferiprone-attenuates-hypertension-vascular-dysfunction-baroreflex-dysfunction-and-oxidative-stress-in-iron-overloaded-mice
#10
Weerapon Sangartit, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Wanida Donpunha, Shigeki Shibahara, Upa Kukongviriyapan
Excessive iron can generate reactive oxygen species (ROS), leading to oxidative stress that is closely associated with cardiovascular dysfunction. Iron overload was induced in male ICR mice by injection of iron sucrose (10mg/kg/day) for eight weeks. Iron overload was evidenced by increased serum iron indices. The mice developed increased blood pressure, impaired vascular function and blunted response of the autonomic nervous system. These effects were accompanied by increased malondialdehyde levels in various tissues, increased nitric oxide metabolites in plasma and urine, and decreased blood glutathione...
December 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27702428/food-sources-of-energy-and-nutrients-in-finnish-girls-and-boys-6-8-years-of-age-the-panic-study
#11
Aino-Maija Eloranta, Taisa Venäläinen, Sonja Soininen, Henna Jalkanen, Sanna Kiiskinen, Ursula Schwab, Timo A Lakka, Virpi Lindi
BACKGROUND: Data on food sources of nutrients are needed to improve strategies to enhance nutrient intake among girls and boys in Western countries. OBJECTIVE: To identify major food sources of energy, energy nutrients, dietary fibre, and micronutrients, and to study gender differences in these food sources among children. DESIGN: We assessed food consumption and nutrient intake using 4-day food records in a population sample of Finnish girls (n=213) and boys (n=217) aged 6-8 years from the Physical Activity and Nutrition in Children Study...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27638196/high-rates-of-microbial-dinitrogen-fixation-and-sulfate-reduction-associated-with-the-mediterranean-seagrass-posidonia-oceanica
#12
Nadine Lehnen, Hannah K Marchant, Anne Schwedt, Jana Milucka, Christian Lott, Miriam Weber, Julien Dekaezemacker, Brandon K B Seah, Philipp F Hach, Wiebke Mohr, Marcel M M Kuypers
Seagrass meadows of Posidonia oceanica represent hotspots of productivity in the oligotrophic Mediterranean Sea. The lack of dissolved inorganic nitrogen (DIN) in the seawater suggests that the N-demand of these meadows might be in part supported by microbial dinitrogen (N2) fixation. However, currently there are no direct N2 fixation measurements available for this productive marine macrophyte. Here we investigated N2 fixation activity associated with P. oceanica leaf, rhizome and root pieces. In 15N2 incubations, the roots exhibited highest rates of N2 fixation...
October 2016: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/27577248/-iron-deficiency-fatigue-and-restless-legs-syndrome
#13
Bettina Wurzinger, Peter König
Iron deficiency without anaemia is a widespread health problem that often remains undetected. In this context, neurological and psychopathological problems like fatigue and poor concentration are a major issue, but also in Restless-Legs-Syndrome (RLS) iron deficiency is a key element.The exact pathogenesis is often unknown, however, it is known that iron is involved in several very important metabolic processes in the human body. In particular when it comes to fatigue and RLS, it's assumed that reduced activity of tyrosine hydroxylase - a central iron-dependent element of dopamine synthesis - can lead to deficiencies...
October 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27576956/pediatric-crohn-s-disease-iron-deficiency-anemia-and-intravenous-iron-treatment-a-follow-up-study
#14
Sara Valério de Azevedo, Catarina Maltez, Ana Isabel Lopes
BACKGROUND AND AIMS: Increasing evidence in adults demonstrates efficacy and safety of IV iron in inflammatory Bowel disease (IBD) associated iron deficiency anemia; however, evidence in pediatric patients is yet scarce and no previous study has included a long follow-up. This study aimed to evaluate safety and efficacy of IV iron (primary end point), and the need of re-treatment (secondary end point), in this setting. METHODS: Prospective recruitment (40 months); PCDAI determined before and after treatment; anemia defined according to WHO criteria; IV iron treatment included iron sucrose and ferric carboxymaltose...
January 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27570231/chronic-iron-overload-induces-gender-dependent-changes-in-iron-homeostasis-lipid-peroxidation-and-clinical-course-of-experimental-autoimmune-encephalomyelitis
#15
Božena Ćurko-Cofek, Tanja Grubić Kezele, Jelena Marinić, Marin Tota, Nada Starčević Čizmarević, Čedomila Milin, Smiljana Ristić, Biserka Radošević-Stašić, Vesna Barac-Latas
To analyze iron- and gender-dependent mechanisms possibly involved in pathogenesis of multiple sclerosis (MS) in this study we evaluated the effects of iron overload (IO) on iron status and lipid peroxidation processes (LPO) in tissues of female and male DA rats during chronic relapsing experimental autoimmune encephalomyelitis, a well-established MS animal model. Rats were treated by iron sucrose (75mg/kg bw/day) or with saline solution during two weeks before the sensitization with bovine brain homogenate in complete Freund's adjuvant...
August 26, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27565570/amd-like-retinopathy-associated-with-intravenous-iron
#16
Delu Song, Levi N Kanu, Yafeng Li, Kristen L Kelly, Rupak K Bhuyan, Tomas Aleman, Jessica I W Morgan, Joshua L Dunaief
Iron accumulation in the retina is associated with the development of age-related macular degeneration (AMD). IV iron is a common method to treat iron deficiency anemia in adults, and its retinal manifestations have not hitherto been identified. To assess whether IV iron formulations can be retina-toxic, we generated a mouse model for iron-induced retinal damage. Male C57BL/6J mice were randomized into groups receiving IV iron-sucrose (+Fe) or 30% sucrose (-Fe). Iron levels in neurosensory retina (NSR), retinal pigment epithelium (RPE), and choroid were assessed using immunofluorescence, quantitative PCR, and the Perls' iron stain...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27565330/dental-pulp-mesenchymal-stem-stromal-cells-labeled-with-iron-sucrose-release-exosomes-and-cells-applied-intra-nasally-migrate-to-intracerebral-glioblastoma
#17
U Altanerova, K Benejova, V Altanerova, S Tyciakova, B Rychly, P Szomolanyi, F Ciampor, M Cihova, V Repiska, K Ondicova, B Mravec, C Altaner
We report on a simple iron oxide (Venofer) labeling procedure of dental pulp mesenchymal stem cells (DP-MSCs) and DP-MSCs transduced with yeast cytosinedeaminase::uracilphosphoribosyltransferase (yCD::UPRT-DP-MSCs). Venofer is a drug approved for intravenous application to treat iron deficiency anemia in patients. Venofer labeling did not affect DP-MSCs or yCD::UPRT-DP-MSCs viability and growth kinetics. Electron microscopy of labeled cells showed internalized Venofer nanoparticles in endosomes. MRI relativity measurement of Venofer labeled DP-MSCs in a phantom arrangement revealed that 100 cells per 0...
2016: Neoplasma
https://www.readbyqxmd.com/read/27542823/is-there-any-role-of-intravenous-iron-for-the-treatment-of-anemia-in-cancer
#18
Cengiz Gemici, Ozlem Yetmen, Gokhan Yaprak, Sevgi Ozden, Huseyin Tepetam, Hazan Ozyurt, Alpaslan Mayadagli
BACKGROUND: Anemia is a major cause of morbidity in patients with cancer resulting in poor physical performance, prognosis and therapy outcome. The aim of this study is to assess the efficacy of intravenous (iv) iron administration for the correction of anemia, for the prevention of exacerbation of anemia, for decreasing blood transfusion rates, and for the survival of cancer patients. METHODS: Patients with different solid tumor diagnosis who received iv iron during their cancer treatment were evaluated retrospectively...
August 20, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27540710/correction-of-iron-deficiency-anemia-with-intravenous-iron-sucrose-in-children-with-inflammatory-bowel-disease
#19
Istvan Danko, Marcy Weidkamp
OBJECTIVES: Iron deficiency anemia (IDA) is common in children with inflammatory bowel disease (IBD) affecting their cognitive development and school performance. Oral iron supplementation has serious limitations including poor adherence and iron malabsorption related to chronic inflammation. Our objective was to evaluate the feasibility of periodic intravenous (IV) iron treatments for correction of IDA in children with IBD. METHODS: This prospective study was conducted in 24 children with IBD treated with infliximab (IFX)...
November 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27529331/nutrient-patterns-and-their-relationship-to-metabolic-syndrome-in-iranian-adults
#20
Sayyed Saeid Khayyatzadeh, Mohsen Moohebati, Mohsen Mazidi, Amir Avan, Maryam Tayefi, Seyed Mohammad Reza Parizadeh, Mahmoud Ebrahimi, Alireza Heidari-Bakavoli, Mahmoud Reza Azarpazhooh, Habibollah Esmaily, Gordon A Ferns, Mohsen Nematy, Mohammad Safarian, Majid Ghayour-Mobarhan
BACKGROUND: The prevalence of metabolic syndrome (MetS) is increasing globally. It is associated with a significant risk of developing type 2 diabetes mellitus and cardiovascular disease. MATERIALS AND METHODS: The relationship between adherence to several different dietary patterns and the presence of MetS was explored in an Iranian population sample of 5764 subjects. RESULTS: We observed that the prevalence of MetS was 13% and 18% in men and women, respectively...
October 2016: European Journal of Clinical Investigation
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