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https://www.readbyqxmd.com/read/29777369/adherence-to-special-diets-and-its-association-with-meeting-the-nutrient-recommendations-in-individuals-with-type-1-diabetes
#1
A J Ahola, C Forsblom, Per-Henrik Groop
AIMS: Not much is known about adherence to special diets in type 1 diabetes, characteristics of individuals with special diets, and whether such practices should raise concerns with respect to meeting the dietary recommendations. In this study, we assessed the frequencies of adherence to special diets, in a population of individuals with type 1 diabetes, and investigated the association between special diet adherence and dietary intake, measured as dietary patterns and nutrient intakes...
May 18, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29699506/correction-to-the-ferumoxytol-for-anemia-of-ckd-trial-fact-a-randomized-controlled-trial-of-repeated-doses-of-ferumoxytol-or-iron-sucrose-in-patients-on-hemodialysis-background-and-rationale
#2
Iain C Macdougall, Naomi V Dahl, Kristine Bernard, Zhu Li, Alka Batycky, William E Strauss
Following publication of the original article [1], the authors reported that one of the authors' name is spelled incorrectly. In this Erratum the incorrect and correct author name are shown. The original publication of this article has been corrected.
April 26, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29680173/iron-deficiency-in-chronic-and-acute-heart-failure-a-contemporary-review-on-intertwined-conditions
#3
REVIEW
Gonçalo J L Cunha, Bruno M L Rocha, Luiz Menezes Falcão
Iron Deficiency (ID) is increasingly recognized as a prevalent comorbid condition in Heart Failure (HF). Despite this, the pathophysiological mechanisms for progressive ID in either chronic or acute HF are still poorly understood. Beyond the traditional factors for iron deficit in the general population, we ought to review the specificities of such paucity in the HF patient, particularly focusing on the interplay between heightened inflammation, overactivity of the sympathetic nervous system and the so-called cardio-renal-anaemia-ID syndrome...
April 18, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29669068/adverse-reactions-after-intravenous-iron-infusion-among-inflammatory-bowel-disease-patients-in-the-united-states-2010-2014
#4
Eboselume Akhuemonkhan, Alyssa Parian, Kathryn A Carson, Susan Hutfless
Background: Anemia is a frequent complication of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD). Intravenous (IV) iron is recommended as the initial therapy for patients with clinically active IBD, severe anemia, and intolerance to oral iron. IV iron is associated with serious adverse effects including a black box warning for anaphylaxis with iron dextran and ferumoxytol. We aimed to examine the occurrence of adverse reactions including anaphylaxis after IV iron infusions in a large database of US IBD patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29599970/medication-practice-in-hospitals-are-nanosimilars-evaluated-and-substituted-correctly
#5
Josefien Knoeff, Beat Flühmann, Stefan Mühlebach
Introduction: This study investigates the drug selection and dispensing behaviour of hospital pharmacists of intravenous iron products including iron sucrose and iron sucrose similar, with special emphasis on substitution and interchangeability in France and Spain. Iron-carbohydrate complex drugs represent different available intravenous iron drugs and are part of the non-biological complex drug (NBCD) class, an expanding drug class with up to 30 brands available in intravenous pharmacotherapy and over 50 in clinical development...
March 2018: European Journal of Hospital Pharmacy. Science and Practice
https://www.readbyqxmd.com/read/29582437/red-blood-cell-transfusion-after-a-global-strategy-for-early-detection-and-treatment-of-iron-deficiency-anemia-three-year-results-of-a-prospective-observational-study
#6
Miguel Angel de Las Nieves Lopez, Ana Maria Matas Cobos, Francisco Sarria Gonzalez, Maria Jose Dominguez Lomeña, Ana Maria Palomo Hernandez, Encarnación Gil Gines, Salvador Serna Juan, Javier Ampuero Ampuero, Antonio Marin Fernandez, Antonia Vazquez de la Villa
BACKGROUND: Anemia is the main indication for red blood cell (RBC) transfusion and iron deficiency is the most prevalent, preventable, and treatable cause of anemia worldwide. We aimed to assess the impact of iron deficiency anemia (IDA) on RBC transfusion by means of a program for prevention, early detection, and treatment. STUDY DESIGN AND METHODS: A prospective observational study was conducted starting in 2014 after an intervention in clinical practice in Melilla, a peripheral city isolated by 207 km sea distance to nearest continental Spain...
March 26, 2018: Transfusion
https://www.readbyqxmd.com/read/29520577/the-use-of-magnetic-resonance-imaging-for-non-invasive-assessment-of-venofer%C3%A2-biodistribution-in-rats
#7
Kimberley Span, Ebel H E Pieters, Wim E Hennink, Annette van der Toorn, Vera Brinks, Rick M Dijkhuizen, Geralda A F van Tilborg
PURPOSE: The aim of this study was to determine the potential of magnetic resonance imaging to evaluate the biodistribution of exogenous iron within 24 h after one single injection of Venofer® (iron sucrose). METHODS: Venofer® was evaluated in vitro for its ability to generate contrast in MR images. Subsequently, iron disposition was assessed in rats with MRI, in vivo up to 3 h and post mortem at 24 h after injection of Venofer®, at doses of 10- and 40 mg/kg body weight (n = 2 × 4), or saline (n = 4)...
March 8, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29520555/financial-impact-of-intravenous-iron-treatments-on-the-management-of-anaemia-inpatients-a-1-year-observational-study
#8
Amina Delpeuch, Marc Ruivard, Armand Abergel, Olivier Aumaitre, Stéphane Boisgard, Sandrine Bagel, Valérie Sautou
Background Intravenous (IV) iron preparations bypass the difficulties (malabsorption and side effects) associated with oral iron for the treatment of iron deficiency anaemia (IDA). Ferric carboxymaltose (FCM) can be administered as a single infusion over short periods of time but is more expensive than iron sucrose (IS) when the patients are hospitalized. Objectives To evaluate the appropriateness of FCM prescriptions and to establish the economic impact of this management (including disease coding) compared to the use of IV IS...
March 8, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29503058/do-patterns-of-nutrient-intake-predict-self-reported-anxiety-depression-and-psychological-distress-in-adults-sepahan-study
#9
Amin Salehi-Abargouei, Ahmad Esmaillzadeh, Leila Azadbakht, Ammar Hassanzadeh Keshteli, Hamid Afshar, Awat Feizi, Christine Feinle-Bisset, Peyman Adibi
BACKGROUND & AIMS: Despite the growing evidence about dietary patterns, this study aimed at the association between patterns of nutrients intake and psychological disorders. METHODS: In this cross-sectional study, diet and psychological factors including anxiety, depression, and general health (GHQ) were assessed through self-administered questionnaires in 3846 Iranian adults. Daily intakes of 57 nutrients and bioactive compounds were calculated. Nutrient patterns (NPs) were derived using factor analysis...
February 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29476246/sucrose-is-involved-in-the-regulation-of-iron-deficiency-responses-in-rice-oryza-sativa-l
#10
Peng-Fei Chen, Lin Chen, Zheng-Rong Jiang, Gao-Peng Wang, Shao-Hua Wang, Yan-Feng Ding
Sucrose signaling pathways were rapidly induced in response to early iron deficiency in rice plants, and the change of sucrose contents in plants was essential for the activation of iron deficiency responses. Sucrose is the main product of photosynthesis in plants, and it functions not only as an energy metabolite but also a signal molecule. However, a few studies have examined the involvement of sucrose in mediating iron deficiency responses in rice. In this study, we found that the decrease in photosynthesis and total chlorophyll concentration (SPAD values) in leaves occurred at a very early stage under iron deficiency...
May 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29475033/morphophysiological-and-transcriptome-analysis-reveals-a-multiline-defense-system-enabling-cyanobacterium-leptolyngbya-strain-jsc-1-to-withstand-iron-induced-oxidative-stress
#11
Sikandar Khan, Jing Lv, Arshad Iqbal, Pengcheng Fu
Iron intoxications induce severe oxidative stress by producing reactive oxygen species (ROS) in cyanobacteria, leading to membrane lipid peroxidation, altered morphology, impaired photosynthesis and other oxidative stress injuries. Given these stresses, mitigation of ROS is a prerequisite for all aerobic organisms. Study of siderophilic cyanobacterium Leptolyngbya strain JSC-1 inhabiting iron-rich hot springs may provide insight into the mechanism of iron homeostasis and alleviation of oxidative stress. In this study, we investigated the morphophysiological and molecular mechanisms enabling this cyanobacterium to cope with iron-induced oxidative stress...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29466796/changes-in-dietary-patterns-and-the-nutritional-status-in-men-in-the-metallurgical-industry-in-poland-over-a-21-year-period
#12
Angelika Edyta Charkiewicz, Jacek Jamiołkowski, Bartosz Pędziński, Michalina Krzyżak, Dominik Maślach, Andrzej Szpak, Wioleta Justyna Omeljaniuk
BACKGROUND/AIMS: The study was carried out to evaluate the changes in the eating habits and lipid parameters in a 21-year follow-up on a group of 435 men living in Poland. METHODS: The studied population was composed of the same subjects: a group of men who were first studied in the years 1987-1989 and in 2008-2010. The following data was gathered: body mass, body mass index (BMI), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride concentration in blood serum...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29466169/-selection-of-optimal-therapy-at-correction-of-the-anemic-syndrome-in-patients-with-chronic-heart-failure
#13
K K Zahidova
PURPOSE: to study efficacy of various schemes of therapy of patients with chronic heart failure (CHF) and anemia. MATERIALS AND METHODS: We included in this study 208 patients with CHF of ishemic etiology (mean age 60.6±1.4 years, 174 with and 34 without anemia). According to therapeutic regimen of the use of methoxy polyethylene glycol-epoetin beta (MEB, 0.60 mсg/kg) and intravenous (IV) iron hydroxide sucrose complex all patients were divided into 4 groups. In all patients before and after treatment we determined Hb, Ht, plasma levels of ferritin, erythropoietin (EPO), NT-proBNP, IL-1, IL-6, TNF-α, transferrin saturation (TS), total vascular peripheral resistance, and parameters of systolic and diastolic function of left ventricular (LV) myocardium (by echocardiography and doppler echocardiography)...
January 2018: Kardiologiia
https://www.readbyqxmd.com/read/29454888/bioequivalence-decision-for-nanoparticular-iron-complex-drugs-for-parenteral-administration-based-on-their-disposition
#14
Julia Schnorr, Sören Fütterer, Karsten Spicher, Maria Catarinolo, Christoph Schlösser, Harald Enzmann, Peter Langguth
Although parenteral iron products have been established to medicinal use decades before, their structure and pharmacokinetic properties are not fully characterized yet. With its' second reflection paper on intravenous iron-based nano-colloidal products (EMA/CHMP/SWP/620008/2012) the European Medicine Agency provided an extensive catalogue of methods for quality, non-clinical and pharmacokinetic studies for the comparison of nano-sized iron products to an originator (EMA, 2015). For iron distribution studies, the reflection paper assumed the use of rodents...
April 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29425576/evidence-based-and-consensus-clinical-practice-guidelines-for-the-iron-treatment-of-restless-legs-syndrome-willis-ekbom-disease-in-adults-and-children-an-irlssg-task-force-report
#15
Richard P Allen, Daniel L Picchietti, Michael Auerbach, Yong Won Cho, James R Connor, Christopher J Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W Winkelman
BACKGROUND: Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend iron treatment when peripheral iron levels are low. In order to assess the evidence on the oral and intravenous (IV) iron treatment of RLS and periodic limb movement disorder (PLMD) in adults and children, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies and provide evidence-based and consensus guidelines for the iron treatment of RLS in adults, and RLS and PLMD in children...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29415929/-pharmacological-pharmaceutical-and-clinical-profiles-of-sucroferric-oxyhydroxide-p-tol-%C3%A2-chewable-tab-250-mg-500-mg-a-therapeutic-agent-for-hyperphosphatemia
#16
Satoshi Tatemichi, Fumiaki Nakagaki, Shoichi Yoshioka, Natsuko Shichiri
Sucroferric oxyhydroxide (P-TOL® chewable tablets, 250 and 500 mg) is a phosphate binder for oral use; it is composed of polynuclear iron (III)-oxyhydroxide, sucrose, and starches, and is currently indicated for alleviating hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis. The results of non-clinical pharmacological studies have suggested that P-TOL consistently decreases serum phosphorus levels in the aqueous environment at pH levels similar to those in the gastrointestinal tract, thereby suppressing the progression of secondary hyperparathyroidism, aberrant calcification, and abnormal bone metabolism associated with hyperphosphatemia...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29414023/a-robust-and-easily-reproducible-protocol-for-the-determination-of-size-and-size-distribution-of-iron-sucrose-using-dynamic-light-scattering
#17
Tiziana Di Francesco, Gerrit Borchard
Iron sucrose (IS), a nanocolloidal solution used in the treatment of iron deficiency anemia, is currently under investigation for the elucidation of its critical quality attributes. Assessment of IS's size and size distribution has been recently attempted using dynamic light scattering (DLS). However, due to heterogeneous interpretation of DLS data, variable results were retrieved. The aim of this work was to establish a simple and reproducible DLS protocol to unequivocally define the size and size distribution of IS by using size distribution approximation in Number...
April 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29335180/synthesis-of-nanometer-sized-fayalite-and-magnesium-iron-ii-mixture-olivines
#18
Odeta Qafoku, Eugene S Ilton, Mark E Bowden, Libor Kovarik, Xin Zhang, Ravi K Kukkadapu, Mark H Engelhard, Christopher J Thompson, Herbert T Schaef, Bernard Peter McGrail, Kevin M Rosso, John S Loring
Olivines are divalent orthosilicates with important geologic, biological, and industrial significance and are typically comprised of mixtures of Mg2+ and Fe2+ ranging from forsterite (Mg2 SiO4 ) to fayalite (Fe2 SiO4 ). Investigating the role of Fe(II) in olivine reactivity requires the ability to synthesize olivines that are nanometer-sized, have different percentages of Mg2+ and Fe2+ , and have good bulk and surface purity. This article demonstrates a new method for synthesizing nanosized fayalite and Mg-Fe mixture olivines...
April 1, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29304848/effectiveness-and-safety-of-ferric-carboxymaltose-compared-to-iron-sucrose-in-women-with-iron-deficiency-anemia-phase-iv-clinical-trials
#19
Amreen Naqash, Rifat Ara, Ghulam N Bader
BACKGROUND: Iron deficiency anemia (IDA) is a significant problem worldwide particularly in women. The aim of the study was to evaluate the effectiveness and safety of intravenous ferric carboxymaltose (FCM) in comparison to iron sucrose (IS) in women with IDA. METHOD: Two hundred patients at Department of Obstetrics and Gynaecology, Sher-i-Kashmir Institute of Medical Sciences Medical College and Hospital, Jammu & Kashmir, India identified with IDA were enrolled for the study...
January 5, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29303999/comparative-evaluation-of-u-s-brand-and-generic-intravenous-sodium-ferric-gluconate-complex-in-sucrose-injection-physicochemical-characterization
#20
Dajun Sun, Rodney Rouse, Vikram Patel, Yong Wu, Jiwen Zheng, Alokita Karmakar, Anil K Patri, Priyanka Chitranshi, David Keire, Jia Ma, Wenlei Jiang
The objective of this study was to evaluate physicochemical equivalence between brand (i.e., Ferrlecit) and generic sodium ferric gluconate (SFG) in sucrose injection by conducting a series of comparative in vitro characterizations using advanced analytical techniques. The elemental iron and carbon content, thermal properties, viscosity, particle size, zeta potential, sedimentation coefficient, and molecular weight were determined. There was no noticeable difference between brand and generic SFG in sucrose injection for the above physical parameters evaluated, except for the sedimentation coefficient determined by sedimentation velocity analytical ultracentrifugation (SV-AUC) and molecular weight by asymmetric field flow fractionation-multi-angle light scattering (AFFF-MALS)...
January 5, 2018: Nanomaterials
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