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intervetebral disc degeneration

Yue-Hui Zhang, Yang-Lu Zhao, Bo Li, Jia Song, Jing Zhang, Jiang Shao
OBJECTIVE: To evaluate transduction efficacy and sustainability of lentiviral vector for intervertebral disc cells both in vitro and in vivo. METHODS: Human nuclear pulposus and anulus fibrosus cells isolated from disc tissue of 28 patients during surgical disc procedures were cultured and subsequently transduced using recombinant lentivirus carrying a gene for enhanced green fluorescent protein at multiplicities of infection of 0, 15, 30, 60, 90, and 150. Cell viability was determined using the trypan blue exclusion test...
March 2018: World Neurosurgery
Alex V Boiwka, Navkirat S Bajwa, Jason O Toy, Jason Eubanks, Nicholas U Ahn
Research has associated lumbar spinal disease with lower extremity arthrosis. These studies focused solely on the lumbar spine's connection with hip or knee pathology, failing to investigate potential ankle relationships. We specifically explored the interplay between lumbar disc degeneration and tibiotalar joint arthritis. Lumbar disc degeneration and tibiotalar joint arthritis was graded 0 to 4, according to osteophytosis of the vertebral rim and talar surface in 710 randomly selected cadaveric specimens...
April 2015: American Journal of Orthopedics
Chang-feng Yao, Yong-jian Zhao, Kai Niu, Yue-li Sun, Chen-guang Li, De-zhi Tang, Bing Shu, Sheng Lu, Chong-jian Zhou, Qian-qian Liang, Qi Shi, Yong-jun Wang
OBJECTIVE: To observe effects of removing arms and ovarian on lumbar intervertebral disc and vertebral bone mineral density (BMD) by establishing rat model of lumbar intervetebral disc degeneration (IDD) with kidney deficiency, and to explore internal mechanism of disc degeneration, relationship between disc degeneration and osteoporosis. METHODS: Thirty Sprague-Dawley female rats aged one month were randomly divided into control group, lumbar IDD group and lumbar IDD with kidney deficiency group (combined group), 10 rats in each group...
December 2013: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Xin Yu, Zheng Li, Jianxiong Shen, William K K Wu, Jinqian Liang, Xisheng Weng, Guixing Qiu
Aberrant proliferation of nucleus pulposus cell is implicated in the pathogenesis of intervertebral disc degeneration. Recent findings revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many pathological conditions. Here, we showed that miR-10b was dramatically upregulated in degenerative nucleus pulposus tissues when compared with nucleus pulposus tissues isolated from patients with idiopathic scoliosis. Moreover, miR-10b levels were associated with disc degeneration grade and downregulation of HOXD10...
2013: PloS One
Yun-Neng Cui, Rong-Ping Zhou, Qi-Guang Mai, Ming Lu, Song Xu, Liang Wang, Shao-Lin Li, Da-di Jin
OBJECTIVE: To establish a rabbit model of intervertebral disc degeneration by puncturing the anulus fibrosus through an approach between the longissimus dorsi muscle and obliquus externus abdominis. METHODS: The L(4/5) and L(5/6) intervetebral discs of 6 New Zealand white rabbits were punctured by an 18-gauge pin in the anterolateral annular fibrosus through an approach between the longissimus dorsi muscle and the obliquus externus abdominis with the right transverse processes of L(5) and L(6) resected; the L(2/3) discs were used as the control without exposure or needle stab, and the L(3/4) discs were subjected to sham operation with the discs exposed but not punctured after resecting the right transverse process of L(4)...
March 2012: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Hao Yu, Yue Zhu
Earlier reports have shown that ADAMTS-7 and ADAMTS-12 (a disintegrin and metalloproteinase with thrombospondin motifs) can bind to and degrade COMP (cartilage oligomeric matrix protein) in cartilage. However, the expression of ADAMTS-7 AND ADAMSTS-12 in both normal intervertebral discs and degenerative intervertebral discs (IVDs) is still unknown and the changes that occur in the degenerating intervertebral disc remain to be determined. The aim of this study was to explore the expression and role of the ADAMTS in the degenerative process of the intervertebral disc...
January 2012: Journal of Veterinary Medical Science
Bin Wang, Zhigang Zhang, Kanghua Li
OBJECTIVE: To explore changes in the height and width of the cervical intervertebral foramina of C6.7 before and after the C5.6 discetomy, the replacement or the anterior intervertebral fusion so as to provide the theoretical basis for the clinical practice. METHODS: Eleven fresh cervical spinal specimens were obtained from young adult cadavers. The specimens of C5.6 were divided into the integrity group, the discectomy group, the artificial disc replacement group, and the intervertebral fusion group...
October 2007: Chinese Journal of Reparative and Reconstructive Surgery
P Kambin, S Abda, F Kurpicki
Rupture of the normal intervertebral disk by manual force is difficult. When the pressure was raised to 9000 mm Hg. in 33 normal intervertebral disks, the volume received did not exceed 0.4 cc. A contained degenerated intervertebral disk can be ruptured by manual force without a simultaneous pressure-controlling device. In cases of traumatic rupture of the annulus fibrosis and of the posterior longitudinal ligament, simultaneous intradiskal pressure and volume recording were more informative than either EMG or myelography...
January 1980: Clinical Orthopaedics and related Research
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