Verena Tenten, Sylvia Menzel, Uta Kunter, Eva-Maria Sicking, Claudia R C van Roeyen, Silja K Sanden, Michaela Kaldenbach, Peter Boor, Astrid Fuss, Sandra Uhlig, Regina Lanzmich, Brigith Willemsen, Henry Dijkman, Martin Grepl, Klemens Wild, Wilhelm Kriz, Bart Smeets, Jürgen Floege, Marcus J Moeller
Under physiologic conditions, significant amounts of plasma protein pass the renal filter and are reabsorbed by proximal tubular cells, but it is not clear whether the endocytosed protein, particularly albumin, is degraded in lysosomes or returned to the circulatory system intact. To resolve this question, a transgenic mouse with podocyte-specific expression of doxycycline-inducible tagged murine albumin was developed. To assess potential glomerular backfiltration, two types of albumin with different charges were expressed...
December 2013: Journal of the American Society of Nephrology: JASN