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https://www.readbyqxmd.com/read/29050043/-malpractice-claims-against-pediatricians-analysis-of-expert-testimonies-from-the-medical-service-of-health-insurance-companies-between-2000-and-2014
#1
Heiko Steinhauer, Joachim Holzschuh, Thomas Böhler
Background In Germany, few data are available on medical malpractice claims against pediatricians. On behalf of Statutory Health Insurance Companies their Medical Service (MDK) regularly offers expert testimony in case of allegations during pediatric treatment. Methods Analysis of 374 written pediatric testimonies, documented between September 1st, 2000 and August 31st, 2014. Results 193 allegations against pediatricians were analysed separately for each sector of care (35% concerning outpatients, 28% normal inpatients, and 37% patients treated in an intensive care unit, ICU)...
October 19, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29049907/clinical-correlates-of-saccadic-eye-movement-in-antipsychotic-na%C3%A3-ve-schizophrenia
#2
Aditi Subramaniam, Vijay Danivas, Sri Mahavir Agarwal, Sunil Kalmady, Venkataram Shivakumar, Anekal C Amaresha, Anushree Bose, Janardhanan C Narayanaswamy, Shivarama Varambally, Samuel B Hutton, Ganesan Venkatasubramanian, Bangalore N Gangadhar
Some aspects of saccadic performance have been found to be abnormal in chronic schizophrenia. The majority of this research has, however, been performed on patients treated with long-term antipsychotic medication. Very few studies have examined saccadic performance in antipsychotic-naïve/free patients. There are also very few studies describing the relationship between saccadic performance and clinical symptoms, particularly in antipsychotic free patients. In this study, we compared pro and antisaccade performance in a large sample of antipsychotic-naïve/free schizophrenia patients (N = 45) with healthy controls (N = 57)...
October 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29049325/effect-of-therapeutic-interchange-on-medication-reconciliation-during-hospitalization-and-upon-discharge-in-a-geriatric-population
#3
Jessica S Wang, Robert L Fogerty, Leora I Horwitz
BACKGROUND: Therapeutic interchange of a same class medication for an outpatient medication is a widespread practice during hospitalization in response to limited hospital formularies. However, therapeutic interchange may increase risk of medication errors. The objective was to characterize the prevalence and safety of therapeutic interchange. METHODS AND FINDINGS: Secondary analysis of a transitions of care study. We included patients over age 64 admitted to a tertiary care hospital between 2009-2010 with heart failure, pneumonia, or acute coronary syndrome who were taking a medication in any of six commonly-interchanged classes on admission: proton pump inhibitors (PPIs), histamine H2-receptor antagonists (H2 blockers), hydroxymethylglutaryl CoA reductase inhibitors (statins), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and inhaled corticosteroids (ICS)...
2017: PloS One
https://www.readbyqxmd.com/read/29048777/nurses-perspectives-on-how-an-e-message-system-supports-cross-sectoral-communication-in-relation-to-medication-administration-a-qualitative-study
#4
Signe Foged, Vibeke Nørholm, Ove Andersen, Helle Vendel Petersen
AIMS AND OBJECTIVES: The aim was to describe nurses' perspectives on how an e-message system supports communication between hospital and home care nurses in relation to medication administration. BACKGROUND: Medication administration is a complex process involving a high risk of error. Unclear communication and lack of updated information about medication have been identified as the leading cause of medication errors during care transitions. E-message systems are progressively being used to improve information exchange across sectors, yet little is known about their usage for exchange of medication information between nurses...
October 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29048753/medication-errors-at-hospital-admission-and-discharge-in-type-1-and-2-diabetes
#5
C Breuker, V Macioce, T Mura, Y Audurier, C Boegner, A Jalabert, M Villiet, A Castet-Nicolas, A Avignon, A Sultan
AIMS: To assess the prevalence and characteristics of medication errors at hospital admission and discharge in people with Type 1 and Type 2 diabetes, and identify potential risk factors for these errors. METHODS: This prospective observational study included all people with Type 1 (n = 163) and Type 2 diabetes (n = 508) admitted to the Diabetology-Department of the University Hospital of Montpellier, France, between 2013 and 2015. Pharmacists conducted medication reconciliation within 24 h of admission and at hospital discharge...
October 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29045679/prostate-cancer-patient-characteristics-associated-with-a-strong-preference-to-preserve-sexual-function-and-receipt-of-active-surveillance
#6
James R Broughman, Ramsankar Basak, Matthew E Nielsen, Bryce B Reeve, Deborah S Usinger, Kiayni C Spearman, Paul A Godley, Ronald C Chen
Background: Men with early-stage prostate cancer have multiple options that have similar oncologic efficacy but vary in terms of their impact on quality of life. In low-risk cancer, active surveillance is the option that best preserves patients' sexual function, but it is unknown if patient preference affects treatment selection. Our objectives were to identify patient characteristics associated with a strong preference to preserve sexual function and to determine whether patient preference and baseline sexual function level are associated with receipt of active surveillance in low-risk cancer...
October 16, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29045651/clinical-decision-support-alert-malfunctions-analysis-and-empirically-derived-taxonomy
#7
Adam Wright, Angela Ai, Joan Ash, Jane F Wiesen, Thu-Trang T Hickman, Skye Aaron, Dustin McEvoy, Shane Borkowsky, Pavithra I Dissanayake, Peter Embi, William Galanter, Jeremy Harper, Steve Z Kassakian, Rachel Ramoni, Richard Schreiber, Anwar Sirajuddin, David W Bates, Dean F Sittig
Objective: To develop an empirically derived taxonomy of clinical decision support (CDS) alert malfunctions. Materials and Methods: We identified CDS alert malfunctions using a mix of qualitative and quantitative methods: (1) site visits with interviews of chief medical informatics officers, CDS developers, clinical leaders, and CDS end users; (2) surveys of chief medical informatics officers; (3) analysis of CDS firing rates; and (4) analysis of CDS overrides. We used a multi-round, manual, iterative card sort to develop a multi-axial, empirically derived taxonomy of CDS malfunctions...
October 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29045237/monoplane-3d-2d-registration-of-cerebral-angiograms-based-on-multi-objective-stratified-optimization
#8
Timur Aksoy, Ziga Spiclin, Franjo Pernus, Gozde Unal
Registration of 3D pre-interventional to 2D intra-interventional medical images has an increasingly important role in surgical planning, navigation and treatment, because it enables the physician to co-locate depth information given by pre-interventional 3D images with the live information in intra-interventional 2D images such as X-ray. Most tasks during image-guided interventions are carried out under a monoplane X-ray, which is a highly ill-posed problem for state-of-the-art 3D to 2D registration methods...
October 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29043858/melanoma-segmentation-based-on-deep-learning
#9
Xiaoqing Zhang
Malignant melanoma is one of the most deadly forms of skin cancer, which is one of the world's fastest-growing cancers. Early diagnosis and treatment is critical. In this study, a neural network structure is utilized to construct a broad and accurate basis for the diagnosis of skin cancer, thereby reducing screening errors. The technique is able to improve the efficacy for identification of normally indistinguishable lesions (such as pigment spots) versus clinically unknown lesions, and to ultimately improve the diagnostic accuracy...
October 18, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29042838/dose-banding-of-intravenous-piperacillin-tazobactam-in-pediatric-surgical-inpatients
#10
Indrajit S Karande, Zoy Goff, Jacqueline Kewley, Shailender Mehta, Thomas Snelling
BACKGROUND: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals. OBJECTIVES: To evaluate whether use of dose-banding for IV piperacillin-tazobactam results in acceptable dose variation from standard practice of individualized prescription of 100 mg/kg in children...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29042833/impact-of-a-pharmacist-led-chemotherapy-education-program-on-the-knowledge-of-pediatric-hematology-oncology-nurses
#11
Christine M Fisher, Abby J Kim, Joshua J Elder
OBJECTIVES: Medication errors involving chemotherapy are a serious source of avoidable medical harm that can result in chemotherapy-related adverse drug events. Efforts to reduce errors in the past decade have largely focused on chemotherapy errors at the prescriber level, using computerized or automated technology, but little has been done to ensure chemotherapy is administered accurately at the nursing level. The current study implemented a pharmacist-led, supplemental, institution-specific training program to nursing staff regarding the use of chemotherapy and to address knowledge deficits in newly hired nursing personnel...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29041800/an-exploration-of-the-knowledge-attitudes-and-beliefs-of-xhosa-men-concerning-traditional-circumcision
#12
Salome Froneman, Paul A Kapp
BACKGROUND: The practice of traditional circumcision is associated with considerable morbidity and mortality, yet there is a paucity of literature that provides an understanding of the cultural values that influence men to choose traditional rather than medical circumcision.The aim of this study was to better understand the culture surrounding traditional circumcision, with a view to addressing morbidity and mortality rates associated with the Xhosa male initiation rituals.We explored Xhosa men's perceptions regarding the need for the risks and the social pressure to undergo traditional circumcision, the impact of non-initiation or failed initiation and the perceived barriers to obtaining medical help for the complications of traditional circumcisions...
October 13, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29040416/fractionating-the-neurocognitive-mechanisms-underlying-working-memory-independent-effects-of-dopamine-and-parkinson-s-disease
#13
Sean James Fallon, Rozemarijn Margaretha Mattiesing, Kinan Muhammed, Sanjay Manohar, Masud Husain
Deficits in working memory (WM) in Parkinson's disease (PD) are often considered to be secondary to dopaminergic depletion. However, the neurocognitive mechanisms by which dopamine causes these deficits remain highly contested, and PD is now also known to be associated with nondopaminergic pathology. Here, we examined how PD and dopaminergic medication modulate three components of WM: maintenance over time, updating contents with new information and making memories distracter-resistant. Compared with controls, patients were disproportionately impaired when retaining information for longer durations...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040395/human-genome-sequencing-at-the-population-scale-a-primer-on-high-throughput-dna-sequencing-and-analysis
#14
Rachel L Goldfeder, Dennis P Wall, Muin J Khoury, John P A Ioannidis, Euan A Ashley
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyzed, enables fast and affordable sequencing of full human genomes. As the price of sequencing continues to decline, more and more individuals are having their genomes sequenced...
October 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29040292/intereye-comparison-of-ocular-factors-in-normal-tension-glaucoma-with-asymmetric-visual-field-loss-in-korean-population
#15
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons. PATIENTS AND METHODS: Medical records of NTG patients with asymmetric and symmetric VF losses were retrospectively reviewed. The criterion for asymmetry in VF was 6 dB difference of mean deviation. Refractive error, intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient...
2017: PloS One
https://www.readbyqxmd.com/read/29037823/the-development-of-a-novel-perfused-cadaver-model-with-dynamic-vital-sign-regulation-and-real-world-scenarios-to-teach-surgical-skills-and-error-management
#16
Michael Minneti, Craig J Baker, Maura E Sullivan
The landscape of graduate medical education has changed dramatically over the past decade and the traditional apprenticeship model has undergone scrutiny and modifications. The mandate of the 80-hour work-week, the introduction of integrated residency programs, increased global awareness about patient safety along with financial constraints have spurred changes in graduate educational practices. In addition, new technologies, more complex procedures, and a host of external constraints have changed where and how we teach technical and procedural skills...
October 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29037821/validation-of-a-novel-inverted-peg-transfer-task-advancing-beyond-the-regular-peg-transfer-task-for-surgical-simulation-based-assessment
#17
Amro M Abdelrahman, Denny Yu, Bethany R Lowndes, EeeLN H Buckarma, Becca L Gas, David R Farley, Juliane Bingener, M Susan Hallbeck
OBJECTIVE: To evaluate the validity of a novel inverted peg transfer (iPT) task for assessing laparoscopic skills of novices and experts and compare iPT to the regular PT (rPT) task to ensure surgical trainee acquisition of an adequate advanced laparoscopic skills level for safe laparoscopic practice in the operating room. DESIGN: Prospective crossover study. SETTING: Multidisciplinary simulation center and motion analysis laboratory, Mayo Clinic...
October 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29037222/the-efficacy-and-stability-of-an-information-and-communication-technology-based-centralized-monitoring-system-of-adherence-to-immunosuppressive-medication-in-kidney-transplant-recipients-study-protocol-for-a-randomized-controlled-trial
#18
Hee-Yeon Jung, Sook Jin Seong, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Young-Ran Yoon, Hyung-Kee Kim, Seung Huh, Se-Hee Yoon, Jong Soo Lee, Yong-Lim Kim
BACKGROUND: Immunosuppression non-adherence in kidney transplant recipients (KTRs) not only increases the risk of medical intervention due to acute rejection and graft loss but burdens the socioeconomic system in the form of increased healthcare costs. An aggressive preemptive effort by healthcare professionals, geared to ensure adherence to immunosuppressants in KTRs, is significant and imperative. METHODS/DESIGN: This study was designed as a prospective, open-label, multicenter, randomized controlled study aimed at evaluating the efficacy and stability of an information and communication technology (ICT)-based centralized monitoring system in boosting medication adherence in KTRs...
October 16, 2017: Trials
https://www.readbyqxmd.com/read/29037046/admet-evaluation-in-drug-discovery-18-reliable-prediction-of-chemical-induced-urinary-tract-toxicity-by-boosting-machine-learning-approaches
#19
Tailong Lei, Huiyong Sun, Yu Kang, Feng Zhu, Hui Liu, Wenfang Zhou, Zhe Wang, Dan Li, Youyong Li, Tingjun Hou
Xenobiotic chemicals and their metabolites are mainly excreted out of our bodies by the The urinary tract is the main organ excreting xenobiotic chemicals and their metabolites through the urine. Chemical-induced urinary tract toxicity is one of the main reasons that cause failure during drug development, and it is a common adverse event for medications, natural supplements and environmental chemicals. Despites its importance, there are only a few in silico models for assessing urinary tract toxicity for a large number of compounds with diverse chemical structures...
October 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29035967/pediatric-clinical-handover-a-best-practice-implementation-project
#20
Zhuowen Yu, Yuxia Zhang, Ying Gu, Xiaofeng Xu, Alexa McArthur
BACKGROUND: Communication of information between and among healthcare providers is an essential element of patient care. Poor clinical handover has been associated with inaccurate clinical assessment and diagnosis, delays in diagnosis, medication errors and decreased patient satisfaction. Effective and efficient transition of patient care information requires an evidence-based handover approach. OBJECTIVES: The aim of this evidence implementation project was to make a contribution to promote evidence-based practice in clinical handover in a pediatric setting and thereby enhance patient safety and service delivery...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
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