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https://www.readbyqxmd.com/read/27880955/long-term-angiotensin-ii-receptor-blockade-limits-hypertension-aortic-dysfunction-and-structural-remodeling-in-a-rat-model-of-chronic-kidney-disease
#1
Omar Z Ameer, Mark Butlin, Elena Kaschina, Manuela Sommerfeld, Alberto P Avolio, Jacqueline K Phillips
BACKGROUND/AIMS: Chronic kidney disease (CKD) is associated with large artery remodeling, endothelial dysfunction and calcification, with angiotensin II (Ang II) a known driver of these pathologies. We investigated long-term Ang II type 1 receptor inhibition with valsartan on aortic function and structure in the Lewis polycystic kidney (LPK) rat model of CKD. METHODS: Mixed sex LPK and Lewis control (total n = 28) treated (valsartan 60 mg/kg/day p.o. from 4 to 18 weeks) and vehicle groups were studied...
November 24, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27874273/association-testing-of-vasopressin-receptor-1a-microsatellite-polymorphisms-in-non-clinical-autism-spectrum-phenotypes
#2
Tanya L Procyshyn, Peter L Hurd, Bernard J Crespi
Variation in the arginine vasopressin receptor 1a (AVPR1a) gene is associated with autism risk in clinical populations and with variation in social behavior in non-clinical populations. However, whether a relationship exists between AVPR1a polymorphisms and non-clinical manifestations of autism spectrum phenotypes has not been established. In this study, 873 Caucasian university students were administered the Autism-spectrum Quotient (AQ) questionnaire and genotyped for the RS1 and RS3 microsatellites. A significant association was found between RS3 microsatellite variation and AQ score, with the long/long RS3 genotype associated with higher AQ score...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27870395/sex-differences-in-associations-of-arginine-vasopressin-and-oxytocin-with-resting-state-functional-brain-connectivity
#3
Leah H Rubin, Li Yao, Sarah K Keedy, James L Reilly, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Scot K Hill, Wei Liao, Gong-Jun Ji, Su Lui, John A Sweeney
Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27855412/a-46-xx-ovotesticular-disorder-of-sex-development-likely-caused-by-a-steroidogenic-factor-1-nr5a1-variant
#4
Jonathan M Swartz, Ryan Ciarlo, Michael H Guo, Aser Abrha, Benjamin Weaver, David A Diamond, Yee-Ming Chan, Joel N Hirschhorn
BACKGROUND: A variant in steroidogenic factor-1 (SF-1, encoded by the gene NR5A1), p.Arg92Trp, has recently been reported in multiple families with 46,XX ovotesticular or testicular disorders of sex development (DSD). This amino acid change impacts the DNA-binding domain and perturbs gonadal differentiation pathways. METHODS: Whole-exome sequencing was performed on a 46,XX subject with ovotesticular DSD. RESULTS: Exome results identified a heterozygous NR5A1 variant, p...
November 18, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27833161/12-months-metabolic-changes-among-gender-dysphoric-individuals-under-cross-sex-hormone-treatment-a-targeted-metabolomics-study
#5
Matthias K Auer, Alexander Cecil, Yasmin Roepke, Charlotte Bultynck, Charlotte Pas, Johannes Fuss, Cornelia Prehn, Rui Wang-Sattler, Jerzy Adamski, Günter K Stalla, Guy T'Sjoen
Metabolomic analyses in epidemiological studies have demonstrated a strong sexual dimorphism for most metabolites. Cross-sex hormone treatment (CSH) in transgender individuals enables the study of metabolites in a cross-gender setting. Targeted metabolomic profiling of serum of fasting transmen and transwomen at baseline and following 12 months of CSH (N = 20/group) was performed. Changes in 186 serum metabolites and metabolite ratios were determined by targeted metabolomics analysis based on ESI-LC-MS/MS...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807133/serotonin-and-arginine-vasopressin-mediate-sex-differences-in-the-regulation-of-dominance-and-aggression-by-the-social-brain
#6
Joseph I Terranova, Zhimin Song, Tony E Larkin, Nathan Hardcastle, Alisa Norvelle, Ansa Riaz, H Elliott Albers
There are profound sex differences in the incidence of many psychiatric disorders. Although these disorders are frequently linked to social stress and to deficits in social engagement, little is known about sex differences in the neural mechanisms that underlie these phenomena. Phenotypes characterized by dominance, competitive aggression, and active coping strategies appear to be more resilient to psychiatric disorders such as posttraumatic stress disorder (PTSD) compared with those characterized by subordinate status and the lack of aggressiveness...
November 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27804047/chimpanzee-personality-and-the-arginine-vasopressin-receptor-1a-genotype
#7
V A D Wilson, A Weiss, T Humle, N Morimura, T Udono, G Idani, T Matsuzawa, S Hirata, M Inoue-Murayama
Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness. In chimpanzees, AVPR1a polymorphisms have been associated with traits important for social interactions, including sociability, joint attention, dominance, conscientiousness, and hierarchical personality dimensions named low alpha/stability, disinhibition, and negative emotionality/low dominance. We examined associations between AVPR1a and six personality domains and hierarchical personality dimensions in 129 chimpanzees (Pan troglodytes) living in Japan or in a sanctuary in Guinea...
November 2, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27743766/genetic-variants-in-oxytocin-receptor-and-arginine-vasopressin-receptor-1a-are-associated-with-the-neural-correlates-of-maternal-and-paternal-affection-towards-their-child
#8
Shota Nishitani, Kazuya Ikematsu, Tsunehiko Takamura, Sumihisa Honda, Koh-Ichiro Yoshiura, Kazuyuki Shinohara
There is extensive evidence in animal studies, particularly in vole species (Microtus), that oxytocin (OT) receptor and arginine-vasopressin (AVP) receptor 1a is critical for the regulation of maternal and paternal behavior, respectively. Human studies have gained insight into the relationship between both hormone receptor gene variants and behavior, but not between the variants and the underlying brain activity. To study this, we investigated the association between neural activation of the anterior prefrontal cortex (APFC) in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A)...
October 13, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27698435/sex-pheromone-recognition-and-characterization-of-three-pheromone-binding-proteins-in-the-legume-pod-borer-maruca-vitrata-fabricius-lepidoptera-crambidae
#9
Aping Mao, Jing Zhou, Bin Mao, Ya Zheng, Yufeng Wang, Daiqin Li, Pan Wang, Kaiyu Liu, Xiaoping Wang, Hui Ai
Pheromone-binding proteins (PBPs) are essential for the filtering, binding and transporting of sex pheromones across sensillum lymph to membrane-associated pheromone receptors of moths. In this study, three novel PBP genes were expressed in Escherichia coli to examine their involvement in the sex pheromone perception of Maruca vitrata. Fluorescence binding experiments indicated that MvitPBP1-3 had strong binding affinities with four sex pheromones. Moreover, molecular docking results demonstrated that six amino acid residues of three MvitPBPs were involved in the binding of the sex pheromones...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27695817/impacts-of-supplemental-arginine-on-the-reproductive-performance-of-fall-lambing-ewes
#10
A R Crane, R R Redden, M L Van Emon, T L Neville, L P Reynolds, J S Caton, C S Schauer
In sheep, embryonic and fetal death during pregnancy can account for 25% to 50% of the total number of corpora lutea (and thus potential embryos). The objective of this study was to determine the effects of injectable and oral Arg supplementation provided for 14 d postbreeding on the reproductive performance of naturally stimulated fall lambing ewes. Rambouillet ewes ( = 210) were exposed to rams equipped with marking harnesses to induce cyclicity in April 2012. Upon estrus detection (d 0) ewes were randomly assigned, in a completely random design, to 1 of 6 treatments for a 14-d treatment period: injectable saline (CON; = 25), injectable Ala (IVALA; = 20), injectable Arg (IVARG; = 23), oral rumen-protected Arg (RPARG; = 20), oral fish meal (FM; = 24), or oral soybean meal (SBM; = 23)...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27664190/sex-differences-in-adult-rat-insulin-and-glucose-responses-to-arginine-programming-effects-of-neonatal-separation-hypoxia-and-hypothermia
#11
Ashley L Gehrand, Brian Hoeynck, Mack Jablonski, Cole Leonovicz, Risheng Ye, Philipp E Scherer, Hershel Raff
Acute neonatal hypoxia, a common stressor, causes a spontaneous decrease in body temperature which may be protective. There is consensus that hypothermia should be prevented during acute hypoxia in the human neonate; however, this may be an additional stress with negative consequences. We hypothesize that maintaining body temperature during hypoxia in the first week of postnatal life alters the subsequent insulin, glucose, and glucagon secretion in adult rats. Rat pups were separated from their dam daily from postnatal days (PD) 2-6 for the following 90 min experimental treatments: (1) normoxic separation (control), (2) hypoxia (8% O2) allowing spontaneous hypothermia, (3) normoxic hypothermia with external cold, and (4) exposure to 8% O2 while maintaining body temperature using external heat...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27641673/arginine-intake-is-associated-with-oxidative-stress-in-a-general-population
#12
Aline Martins de Carvalho, Antonio Anax Falcão de Oliveira, Ana Paula de Melo Loureiro, Gilka Jorge Figaro Gattás, Regina Mara Fisberg, Dirce Maria Marchioni
OBJECTIVE: The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. METHODS: Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population-based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27479314/arginines-plasma-concentration-and-oxidative-stress-in-mild-to-moderate-copd
#13
Angelo Zinellu, Alessandro Giuseppe Fois, Salvatore Sotgia, Elisabetta Sotgiu, Elisabetta Zinellu, Fabiana Bifulco, Arduino A Mangoni, Pietro Pirina, Ciriaco Carru
BACKGROUND: Elevated plasma concentrations of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) have been observed in respiratory conditions such as asthma and cystic fibrosis. Since oxidative stress has been shown to increase the activity of arginine methylating enzymes, hence increased ADMA synthesis, and to reduce ADMA degrading enzymes, hence increased ADMA concentrations, we assessed methylated arginines concentrations in chronic obstructive pulmonary disease (COPD), a disease characterized by increased oxidative stress...
2016: PloS One
https://www.readbyqxmd.com/read/27386336/effects-of-dietary-lysine-levels-on-plasma-free-amino-acid-profile-in-late-stage-finishing-pigs
#14
Naresh Regmi, Taiji Wang, Mark A Crenshaw, Brian J Rude, Guoyao Wu, Shengfa F Liao
Muscle growth requires a constant supply of amino acids (AAs) from the blood. Therefore, plasma AA profile is a critical factor for maximizing the growth performance of animals, including pigs. This research was conducted to study how dietary lysine intake affects plasma AA profile in pigs at the late production stage. Eighteen crossbred (Large White × Landrace) finishing pigs (nine barrows and nine gilts; initial BW 92.3 ± 6.9 kg) were individually penned in an environment controlled barn. Pigs were assigned randomly to one of the three dietary treatments according to a randomized complete block design with sex as block and pig as experiment unit (6 pigs/treatment)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27375045/sex-differences-in-the-effects-of-social-defeat-on-brain-and-behavior-in-the-california-mouse-insights-from-a-monogamous-rodent
#15
Michael Q Steinman, Brian C Trainor
Women are nearly twice as likely as men to be diagnosed with major depressive disorder, yet the use of female animal models in studying the biological basis of depression lags behind that of males. The social defeat model uses social stress to generate depression-like symptoms in order to study the neurobiological mechanisms. In general, social defeat is difficult to apply in female rodents. However, male and female California mice (Peromyscus californicus) are territorial. This allows defeat to be studied in both sexes...
June 30, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27358729/arginine-dimethylation-products-in-pediatric-patients-with-chronic-kidney-disease
#16
Akram E El-Sadek, Eman G Behery, Ahmed A Azab, Naglaa M Kamal, Mostafa A Salama, Waleed E Abdulghany, Enas A A Abdallah
BACKGROUND: arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. PATIENTS AND METHODS: 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. RESULTS: In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: < 0...
August 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27328636/relationship-between-serum-arginase-i-and-l-arginine-or-exhaled-nitric-oxide-in-asthma
#17
Keiki Ogino, Yasushi Obase, Tatsuo Ito, Masaki Fujimura, Eri Eguchi, Masayuki Kubo, Kenjiro Nagaoka, Hiroyuki Nakamura
The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group...
2016: Free Radical Research
https://www.readbyqxmd.com/read/27264226/asymmetric-dimethylarginine-related-arginine-derivatives-and-incident-atrial-fibrillation
#18
Renate B Schnabel, Renke Maas, Na Wang, Xiaoyan Yin, Martin G Larson, Daniel Levy, Patrick T Ellinor, Steven A Lubitz, David D McManus, Jared W Magnani, Dorothee Atzler, Rainer H Böger, Edzard Schwedhelm, Ramachandran S Vasan, Emelia J Benjamin
BACKGROUND: Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain. METHODS AND RESULTS: In 3,310 individuals (mean age 58 ± 10 years, 54% women) from the community-based Framingham Study, we prospectively examined the relations of circulating levels of ADMA, l-arginine, symmetric dimethylarginine (SDMA), and the ratio of l-arginine/ADMA to incidence of AF using proportional hazards regression models...
June 2016: American Heart Journal
https://www.readbyqxmd.com/read/27213443/the-association-of-dietary-l-arginine-intake-and-serum-nitric-oxide-metabolites-in-adults-a-population-based-study
#19
Parvin Mirmiran, Zahra Bahadoran, Asghar Ghasemi, Fereidoun Azizi
This study was conducted to investigate whether regular dietary intake of l-arginine is associated with serum nitrate + nitrite (NOx). In this cross-sectional study, 2771 men and women, who had participated in the third examination of the Tehran Lipid and Glucose Study (2006-2008), were recruited. Demographics, anthropometrics and biochemical variables were evaluated. Dietary data were collected using a validated 168-food item semi-quantitative food frequency questionnaire and dietary intake of l-arginine was calculated...
2016: Nutrients
https://www.readbyqxmd.com/read/27182695/padi4-polymorphisms-in-iranian-patients-with-rheumatoid-arthritis
#20
Elmira Shamsian, Maryam Azarian, Maassoomeh Akhlaghi, Mehrnoosh Samaei, Ahmad Reza Jamshidi, Shirin Assar, Yadollah Shakiba, Farhad Gharibdoost, Keramat Nourijelyani, Mahdi Mahmoudi
AIM: Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects many tissues and organs, but majorly attacks synovial joints. Beyond the major histocompatibility complex (MHC) genes, Peptidyl arginine deiminase type IV (PADI4) has been suggested to be associated with RA susceptibility. Evidence regarding the association of PADI4 single nucleotide polymorphisms (SNP) and RA is controversial, thus we conducted this large-scale case-control study to assess the association of rs874881 and rs11203367 PADI4 SNPs with susceptibility to RA...
May 15, 2016: Acta Reumatológica Portuguesa
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