Paolo Tolomeo, Jawad H Butt, Toru Kondo, Gianluca Campo, Akshay S Desai, Pardeep S Jhund, Lars Køber, Martin P Lefkowitz, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Muthiah Vaduganathan, Michael R Zile, Milton Packer, John Jv McMurray
INTRODUCTION: Blood urea nitrogen (BUN) to creatinine (Cr) ratio (BUN/Cr) is associated with worse outcomes in acute heart failure (HF) but little is known about its importance in chronic HF. METHODS: We combined individual patient data from clinical trials (HFrEF: PARADIGM-HF, ATMOSPHERE & DAPA-HF and HFpEF: PARAGON-HF & I-PRESERVE). The primary outcome examined was a composite time to first HF hospitalization or cardiovascular death; its components and all-cause death were also examined...
December 20, 2023: European Journal of Heart Failure