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https://www.readbyqxmd.com/read/29884228/elevated-levels-of-plasma-symmetric-dimethylarginine-and-increased-arginase-activity-as-potential-indicators-of-cardiovascular-comorbidity-in-rheumatoid-arthritis
#1
Unnikrishnan M Chandrasekharan, Zeneng Wang, Yuping Wu, W H Wilson Tang, Stanley L Hazen, Sihe Wang, M Elaine Husni
BACKGROUND: Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished nitric oxide (NO) production. Because L-arginine is the sole precursor of NO, we hypothesized that levels of L-arginine metabolic products reflecting NO metabolism are altered in patients with RA. METHODS: Plasma samples from patients with RA (n = 119) and age- and sex-matched control subjects (n = 238) were used for this study...
June 8, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29796929/characterizing-amino-acid-biosignatures-amongst-individuals-with-schizophrenia-a-case-control-study
#2
Bing Cao, Dongfang Wang, Elisa Brietzke, Roger S McIntyre, Zihang Pan, Danielle Cha, Joshua D Rosenblat, Hannah Zuckerman, Yaqiong Liu, Qing Xie, Jingyu Wang
Amino acids and derivatives participate in the biosynthesis and downstream effects of numerous neurotransmitters. Variations in specific amino acids have been implicated in the pathophysiology of schizophrenia. Herein, we sought to compare levels of amino acids and derivatives between subjects with schizophrenia and healthy controls (HC). Two hundred and eight subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria (DSM-IV)-defined schizophrenia and 175 age- and sex-matched HC were enrolled...
May 23, 2018: Amino Acids
https://www.readbyqxmd.com/read/29788320/chronic-variable-stress-induces-sex-specific-alterations-in-social-behavior-and-neuropeptide-expression-in-the-mouse
#3
Amanda P Borrow, Natalie J Bales, Sally A Stover, Robert J Handa
Chronic exposure to stressors impairs the function of multiple organ systems and is implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and etiology of disorders associated with chronic stress, most preclinical research examining chronic stressor exposure has focused on male subjects. One potential mediator of the consequences of CVS is oxytocin (OT), a known regulator of stress neurocircuitry and behaviors...
May 16, 2018: Endocrinology
https://www.readbyqxmd.com/read/29759075/metabolic-profiles-in-community-acquired-pneumonia-developing-assessment-tools-for-disease-severity
#4
Pu Ning, Yali Zheng, Qiongzhen Luo, Xiaohui Liu, Yu Kang, Yan Zhang, Rongbao Zhang, Yu Xu, Donghong Yang, Wen Xi, Keqiang Wang, Yusheng Chen, Shuchang An, Zhancheng Gao
BACKGROUND: This study aimed to determine whether community-acquired pneumonia (CAP) had a metabolic profile and whether this profile can be used for disease severity assessment. METHODS: A total of 175 individuals including 119 CAP patients and 56 controls were enrolled and divided into two cohorts. Serum samples from a discovery cohort (n = 102, including 38 non-severe CAP, 30 severe CAP, and 34 age and sex-matched controls) were determined by untargeted ultra-high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based metabolomics...
May 14, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29750417/hits-clip-reveals-sex-differential-rna-binding-and-alterative-splicing-regulation-of-srm160-in-drosophila
#5
Chen Qiu, Yu Zhang, Yu-Jie Fan, Ting-Lin Pang, Yan Su, Shuai Zhan, Yong-Zhen Xu
Serine/arginine (SR)-rich proteins are critical for the regulation of alternative splicing (AS), which generates multiple mRNA isoforms from one gene and provides protein diversity for cell differentiation and tissue development. Genetic evidence suggests that Drosophila genital-specific overexpression of SR-related nuclear matrix protein of 160 kDa (SRm160), an SR protein with a PWI RNA-binding motif, causes defective development only in male flies and results in abnormal male genital structures and abnormal testis...
May 10, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29687090/sex-difference-in-the-effect-of-fetal-exposure-to-maternal-diabetes-on-insulin-secretion
#6
Jean-François Gautier, Lila Sabrina Fetita, Jean-Pierre Riveline, Fidaa Ibrahim, Raphaël Porcher, Charbel Abi Khalil, Gilberto Velho, Simeon-Pierre Choukem, Samy Hadjadj, Etienne Larger, Ronan Roussel, Philippe Boudou, Michel Marre, Eric Ravussin, Franck Mauvais-Jarvis
We previously showed that fetal exposure to maternal type 1 diabetes (T1D) is associated with altered glucose-stimulated insulin secretion in adult offspring. Here, we investigated whether this β -cell defect displays a sex dimorphism. Twenty-nine adult nondiabetic offspring of T1D mothers (ODMs) were compared with 29 nondiabetic offspring of T1D fathers. We measured early insulin secretion in response to oral glucose and insulin secretion rate in response to intravenous glucose ramping. Insulin sensitivity and body composition were assessed by a euglycemic, hyperinsulinemic clamp and dual-energy X-ray absorptiometry, respectively...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29649720/differential-release-of-cell-signaling-metabolites-by-male-and-female-bovine-embryos-cultured-in-vitro
#7
E Gómez, S Carrocera, D Martin, P Herrero, N Canela, M Muñoz
Male and female early bovine embryos show dimorphic transcription that impacts metabolism. Individual release of metabolites was examined in a 24h single culture medium from Day-6 male and female morulae that developed to Day-7 expanded blastocysts. Embryos were produced in vitro, fertilized with a single bull and cultured in SOFaaci+6  g/L BSA. The embryonic sex was identified (amelogenin gene amplification). Embryos (N = 10 males and N = 10 females) and N = 6 blank samples (i.e. SOFaaci+6  g/L BSA incubated with no embryos) were collected from 3 replicates...
July 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/29582894/sex-differences-in-the-associations-between-l-arginine-pathway-metabolites-skeletal-muscle-mass-and-function-and-their-responses-to-resistance-exercise-in-old-age
#8
M Da Boit, S Tommasi, D Elliot, A Zinellu, S Sotgia, R Sibson, J R Meakin, R M Aspden, C Carru, A A Mangoni, S R Gray
OBJECTIVES: The current study was designed to explore the associations between L-arginine metabolites and muscle mass and function in old age, which are largely unknown. DESIGN: The study used a randomised, double-blind, placebo-controlled design. SETTING: The study was carried out in a laboratory setting. PARTICIPANTS: 50 healthy older adults [median age 70 years (IQR 67-73); 27 males]. INTERVENTION: Participants undertook an 18-week resistance exercise program, and a nutritional intervention (fish oil vs...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29553774/effects-of-arginine-vasopressin-on-richardson-s-ground-squirrel-social-and-vocal-behavior
#9
Angela R Freeman, James F Hare, W Gary Anderson, Heather K Caldwell
In nearly every vertebrate species examined thus far arginine vasopressin (AVP) and its homologues modulate behavior; thus, providing rich systems for comparative research. In rodents, AVP is best known for its modulation of social behavior; however, to date, research on AVPs effects on behavior have been limited to laboratory models and a few experiments using large outdoor enclosures. To extend our understanding of AVPs role in modulating social behavior and communication in an ecologically relevant context, we examined the effects of AVP on behavior of free-living Richardson's ground squirrels (Urocitellus richardsonii)...
February 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29503216/the-avpr1a-gene-and-its-single-nucleotide-polymorphism-rs10877969-a-literature-review-of-associations-with-health-conditions-and-pain
#10
REVIEW
Keesha L Roach, Patricia E Hershberger, Julienne N Rutherford, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
Pain is the quintessential symptom for individuals suffering from sickle cell disease (SCD). Although the degree of suffering and the cost of treatment are staggering, SCD continues to be grossly understudied, including a lack of data for pain-related genes and prevalence of polymorphisms in this population. This lack of data adds to the inadequacy of pain therapy in this population. Pain genetics investigators have recently examined allele frequencies of single-nucleotide polymorphisms from candidate genes in people who have SCD...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29494890/outcome-of-diabetes-insipidus-in-patients-with-rathke-s-cleft-cysts
#11
Masahiro Oishi, Yasuhiko Hayashi, Yasuo Sasagawa, Daisuke Kita, Osamu Tachibana, Mitsutoshi Nakada
OBJECTIVES: It is well-known that Rathke's cleft cysts (RCCs) infrequently cause headache, endocrinological dysfunction, and visual disturbance, and in rare cases, cause diabetes insipidus (DI). Although surgical evacuation of the cyst content can result in high rates of symptomatic improvement, not only the treatment efficacy but also the pathophysiology of DI with RCC are undetermined. The aim of this study is to elucidate the underlying mechanisms and outcomes of DI associated with RCCs...
April 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29487501/a-review-of-oxytocin-and-arginine-vasopressin-receptors-and-their-modulation-of-autism-spectrum-disorder
#12
REVIEW
Ilaria Cataldo, Atiqah Azhari, Gianluca Esposito
Oxytocin ( OXT ) and arginine-vasopressin ( AVP ) play a key regulatory part in social and affiliative behaviors; two aspects highly compromised in Autism Spectrum Disorder (ASD). Furthermore, variants in the adjacent oxytocin-vasopressin gene regions have been found to be associated with ASD diagnosis and endophenotypes. This review focuses mainly on common OXTr single nucleotide polymorphisms (SNPs), AVPR1a microsatellites and AVPR1b polymorphisms in relation to the development of autism. Although these genes did not surface in genome-wide association studies, evidence supports the hypothesis that these receptors and their polymorphisms are widely involved in the regulation of social behavior, and in modulating neural and physiological pathways contributing to the etiology of ASD...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29422298/amino-acid-profiles-of-young-adults-differ-by-sex-body-mass-index-and-insulin-resistance
#13
M Guevara-Cruz, J M Vargas-Morales, A L Méndez-García, A M López-Barradas, O Granados-Portillo, G Ordaz-Nava, A K Rocha-Viggiano, C A Gutierrez-Leyte, E Medina-Cerda, J L Rosado, J C Morales, N Torres, A R Tovar, L G Noriega
BACKGROUND AND AIMS: An increase in plasma branched-chain amino acids is associated with a higher risk of developing type 2 diabetes and cardiovascular diseases. However, little is known about the basal plasma amino acid concentrations in young adults. Our aim was to determine the plasma amino acid profiles of young adults and to evaluate how these profiles were modified by sex, body mass index (BMI) and insulin resistance (IR). METHODS AND RESULTS: We performed a transversal study with 608 Mexican young adults aged 19...
April 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29414332/effects-of-mclr-exposure-on-sex-hormone-synthesis-and-reproduction-related-genes-expression-of-testis-in-male-rana-nigromaculata
#14
Xiuying Jia, Zhengquan Liu, Xiangjun Lu, Juan Tang, Yingzhu Wu, Qiongxia Du, Jianbo He, Xinyun Zhang, Jinxiao Jiang, Wenli Liu, Yuqing Zheng, Ying Ding, Weiqin Zhu, Hangjun Zhang
Microcystin-leucine-arginine (MCLR) is the most popular and toxic variant among microcystins, which can cause severe reproductive toxicity to animals. However, the mechanisms of reproductive toxicity induced by MCLR in amphibians are still not entirely clear. In the current study, toxicity mechanisms of MCLR on the reproductive system of male Rana nigromaculata followed by low concentration (0, 0.1, 1, and 10 μg/L) and short-term (0, 7, and 14 days) MCLR exposure were shown. It was observed that MCLR could be bioaccumulated in the testes of male frogs, and the theoretical bioaccumulation factor values were 0...
May 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29404822/effects-of-temperature-and-melatonin-on-day-night-expression-patterns-of-arginine-vasotocin-and-isotocin-mrna-in-the-diencephalon-of-a-temperate-wrasse-halichoeres-tenuispinis
#15
Selma Bouchekioua, Sung-Pyo Hur, Yuki Takeuchi, Young-Don Lee, Akihiro Takemura
Most wrasses are protogynous species that swim to feed, reproduce during the daytime, and bury themselves under the sandy bottom at night. In temperate and subtropical wrasses, low temperature influences emergence from the sandy bottom in the morning, and induces a hibernation-like state in winter. We cloned and characterized the prohormone complementary DNAs (cDNAs) of arginine vasotocin (AVT) and isotocin (IT) in a temperate wrasse (Halichoeres tenuispinis) and examined the effects of day/night and temperature on their expression in the diencephalon, because these neurohypophysial peptides are related to the sex behavior of wrasses...
February 5, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29369738/sex-and-nitric-oxide-bioavailability-interact-to-modulate-interstitial-po-2-in-healthy-rat-skeletal-muscle
#16
Jesse C Craig, Trenton D Colburn, Daniel M Hirai, Michael J Schettler, Timothy I Musch, David C Poole
Pre-menopausal women express reduced blood pressure and risk of cardiovascular disease relative to age-matched men. This purportedly relates to elevated estrogen levels increasing nitric oxide synthase (NOS) activity and NO-mediated vasorelaxation. We tested the hypotheses that female rat skeletal muscle would: 1) evince higher O2 delivery-to-utilization ratio (Q̇O2 /V̇O2 ) during contractions; and 2) express greater modulation of Q̇O2 /V̇O2 with changes to NO bioavailability, compared to males. The spinotrapezius muscle of Sprague-Dawley rats (females (♀)=8, males (♂)=8) was surgically exposed and electrically-stimulated (180s, 1Hz, 6V)...
January 25, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#17
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29222403/common-pathophysiology-in-multiple-mouse-models-of-pitt-hopkins-syndrome
#18
Courtney Thaxton, Alexander D Kloth, Ellen P Clark, Sheryl S Moy, Raymond A Chitwood, Benjamin D Philpot
Mutations or deletions of the transcription factor TCF4 are linked to Pitt-Hopkins syndrome (PTHS) and schizophrenia, suggesting that the precise pathogenic mutations dictate cellular, synaptic, and behavioral consequences. Here, we generated two novel mouse models of PTHS, one that mimics the most common pathogenic TCF4 point mutation (human R580W, mouse R579W) and one that deletes three pathogenic arginines, and explored phenotypes of these lines alongside models of pan-cellular or CNS-specific heterozygous Tcf4 disruption...
January 24, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29201907/developmental-testicular-expression-cloning-and-characterization-of-rat-hdac6-in-silico
#19
Pratibha Verma, Omshree Shetty, Sweta Parab, Karen Menezes, Priyanka Parte
We had previously reported presence of histone deacetylase 6 (HDAC6) in sperm and demonstrated its tubulin deacetylase activity and role in sperm motility in rat. In the present study we report its abundant expression in testis, epididymis, accessory sex organs, brain, and adrenal. In the testis, HDAC6 transcript and protein were observed throughout development. We therefore cloned the gene from rat testis using primers for hdac6 (accession number XM_228753.8) in order to determine the role of acetylation/deacetylation in spermatogenesis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29198107/fingerprint-analysis-moving-toward-multiattribute-determination-via-individual-markers
#20
Erica Brunelle, Crystal Huynh, Eden Alin, Morgan Eldridge, Anh Minh Le, Lenka Halámková, Jan Halámek
Forensic science will be forever revolutionized if law enforcement can identify personal attributes of a person of interest solely from a fingerprint. For the past 2 years, the goal of our group has been to establish a way to identify originator attributes, specifically biological sex, from a single analyte. To date, an enzymatic assay and two chemical assays have been developed for the analysis of multiple analytes. In this manuscript, two additional assays have been developed. This time, however, the assays utilize only one amino acid each...
January 2, 2018: Analytical Chemistry
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