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arginine sex

Shota Nishitani, Kazuya Ikematsu, Tsunehiko Takamura, Sumihisa Honda, Koh-Ichiro Yoshiura, Kazuyuki Shinohara
There is extensive evidence in animal studies, particularly in vole species (Microtus), that oxytocin (OT) receptor and arginine-vasopressin (AVP) receptor 1a is critical for the regulation of maternal and paternal behavior, respectively. Human studies have gained insight into the relationship between both hormone receptor gene variants and behavior, but not between the variants and the underlying brain activity. To study this, we investigated the association between neural activation of the anterior prefrontal cortex (APFC) in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A)...
October 12, 2016: Hormones and Behavior
Aping Mao, Jing Zhou, Bin Mao, Ya Zheng, Yufeng Wang, Daiqin Li, Pan Wang, Kaiyu Liu, Xiaoping Wang, Hui Ai
Pheromone-binding proteins (PBPs) are essential for the filtering, binding and transporting of sex pheromones across sensillum lymph to membrane-associated pheromone receptors of moths. In this study, three novel PBP genes were expressed in Escherichia coli to examine their involvement in the sex pheromone perception of Maruca vitrata. Fluorescence binding experiments indicated that MvitPBP1-3 had strong binding affinities with four sex pheromones. Moreover, molecular docking results demonstrated that six amino acid residues of three MvitPBPs were involved in the binding of the sex pheromones...
October 4, 2016: Scientific Reports
A R Crane, R R Redden, M L Van Emon, T L Neville, L P Reynolds, J S Caton, C S Schauer
In sheep, embryonic and fetal death during pregnancy can account for 25% to 50% of the total number of corpora lutea (and thus potential embryos). The objective of this study was to determine the effects of injectable and oral Arg supplementation provided for 14 d postbreeding on the reproductive performance of naturally stimulated fall lambing ewes. Rambouillet ewes ( = 210) were exposed to rams equipped with marking harnesses to induce cyclicity in April 2012. Upon estrus detection (d 0) ewes were randomly assigned, in a completely random design, to 1 of 6 treatments for a 14-d treatment period: injectable saline (CON; = 25), injectable Ala (IVALA; = 20), injectable Arg (IVARG; = 23), oral rumen-protected Arg (RPARG; = 20), oral fish meal (FM; = 24), or oral soybean meal (SBM; = 23)...
August 2016: Journal of Animal Science
Ashley L Gehrand, Brian Hoeynck, Mack Jablonski, Cole Leonovicz, Risheng Ye, Philipp E Scherer, Hershel Raff
Acute neonatal hypoxia, a common stressor, causes a spontaneous decrease in body temperature which may be protective. There is consensus that hypothermia should be prevented during acute hypoxia in the human neonate; however, this may be an additional stress with negative consequences. We hypothesize that maintaining body temperature during hypoxia in the first week of postnatal life alters the subsequent insulin, glucose, and glucagon secretion in adult rats. Rat pups were separated from their dam daily from postnatal days (PD) 2-6 for the following 90 min experimental treatments: (1) normoxic separation (control), (2) hypoxia (8% O2) allowing spontaneous hypothermia, (3) normoxic hypothermia with external cold, and (4) exposure to 8% O2 while maintaining body temperature using external heat...
September 2016: Physiological Reports
Aline Martins de Carvalho, Antonio Anax Falcão de Oliveira, Ana Paula de Melo Loureiro, Gilka Jorge Figaro Gattás, Regina Mara Fisberg, Dirce Maria Marchioni
OBJECTIVE: The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. METHODS: Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population-based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders...
July 26, 2016: Nutrition
Angelo Zinellu, Alessandro Giuseppe Fois, Salvatore Sotgia, Elisabetta Sotgiu, Elisabetta Zinellu, Fabiana Bifulco, Arduino A Mangoni, Pietro Pirina, Ciriaco Carru
BACKGROUND: Elevated plasma concentrations of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) have been observed in respiratory conditions such as asthma and cystic fibrosis. Since oxidative stress has been shown to increase the activity of arginine methylating enzymes, hence increased ADMA synthesis, and to reduce ADMA degrading enzymes, hence increased ADMA concentrations, we assessed methylated arginines concentrations in chronic obstructive pulmonary disease (COPD), a disease characterized by increased oxidative stress...
2016: PloS One
Naresh Regmi, Taiji Wang, Mark A Crenshaw, Brian J Rude, Guoyao Wu, Shengfa F Liao
Muscle growth requires a constant supply of amino acids (AAs) from the blood. Therefore, plasma AA profile is a critical factor for maximizing the growth performance of animals, including pigs. This research was conducted to study how dietary lysine intake affects plasma AA profile in pigs at the late production stage. Eighteen crossbred (Large White × Landrace) finishing pigs (nine barrows and nine gilts; initial BW 92.3 ± 6.9 kg) were individually penned in an environment controlled barn. Pigs were assigned randomly to one of the three dietary treatments according to a randomized complete block design with sex as block and pig as experiment unit (6 pigs/treatment)...
2016: SpringerPlus
Michael Q Steinman, Brian C Trainor
Women are nearly twice as likely as men to be diagnosed with major depressive disorder, yet the use of female animal models in studying the biological basis of depression lags behind that of males. The social defeat model uses social stress to generate depression-like symptoms in order to study the neurobiological mechanisms. In general, social defeat is difficult to apply in female rodents. However, male and female California mice (Peromyscus californicus) are territorial. This allows defeat to be studied in both sexes...
June 30, 2016: Seminars in Cell & Developmental Biology
Akram E El-Sadek, Eman G Behery, Ahmed A Azab, Naglaa M Kamal, Mostafa A Salama, Waleed E Abdulghany, Enas A A Abdallah
BACKGROUND: arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. PATIENTS AND METHODS: 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels. RESULTS: In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: < 0...
August 2016: Annals of Medicine and Surgery
Keiki Ogino, Yasushi Obase, Tatsuo Ito, Masaki Fujimura, Eri Eguchi, Masayuki Kubo, Nagaoka Kenjiro, Hiroyuki Nakamura
The relationship between serum arginase I and serum L-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and L-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and hs-CRP were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group...
June 21, 2016: Free Radical Research
Renate B Schnabel, Renke Maas, Na Wang, Xiaoyan Yin, Martin G Larson, Daniel Levy, Patrick T Ellinor, Steven A Lubitz, David D McManus, Jared W Magnani, Dorothee Atzler, Rainer H Böger, Edzard Schwedhelm, Ramachandran S Vasan, Emelia J Benjamin
BACKGROUND: Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain. METHODS AND RESULTS: In 3,310 individuals (mean age 58 ± 10 years, 54% women) from the community-based Framingham Study, we prospectively examined the relations of circulating levels of ADMA, l-arginine, symmetric dimethylarginine (SDMA), and the ratio of l-arginine/ADMA to incidence of AF using proportional hazards regression models...
June 2016: American Heart Journal
Parvin Mirmiran, Zahra Bahadoran, Asghar Ghasemi, Fereidoun Azizi
This study was conducted to investigate whether regular dietary intake of l-arginine is associated with serum nitrate + nitrite (NOx). In this cross-sectional study, 2771 men and women, who had participated in the third examination of the Tehran Lipid and Glucose Study (2006-2008), were recruited. Demographics, anthropometrics and biochemical variables were evaluated. Dietary data were collected using a validated 168-food item semi-quantitative food frequency questionnaire and dietary intake of l-arginine was calculated...
2016: Nutrients
Elmira Shamsian, Maryam Azarian, Maassoomeh Akhlaghi, Mehrnoosh Samaei, Ahmad Reza Jamshidi, Shirin Assar, Yadollah Shakiba, Farhad Gharibdoost, Keramat Nourijelyani, Mahdi Mahmoudi
AIM: Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects many tissues and organs, but majorly attacks synovial joints. Beyond the major histocompatibility complex (MHC) genes, Peptidyl arginine deiminase type IV (PADI4) has been suggested to be associated with RA susceptibility. Evidence regarding the association of PADI4 single nucleotide polymorphisms (SNP) and RA is controversial, thus we conducted this large-scale case-control study to assess the association of rs874881 and rs11203367 PADI4 SNPs with susceptibility to RA...
May 15, 2016: Acta Reumatológica Portuguesa
Sapna S Shah, Claudia E Ramirez, Alvin C Powers, Chang Yu, Cyndya A Shibao, James M Luther
OBJECTIVE: Metabolic syndrome is associated with insulin resistance and increased future risk of type 2 diabetes. This study investigates the relationship between insulin secretion, insulin resistance and individual metabolic syndrome components in subjects without a prior diagnosis of diabetes. RESEARCH DESIGN AND METHODS: We assessed insulin secretion during hyperglycemic clamps by infusing dextrose to maintain hyperglycemia (200mg/dL), followed by L-arginine administration...
June 2016: Metabolism: Clinical and Experimental
Eugene P Rhee, Clary B Clish, Julia Wenger, Jason Roy, Sammy Elmariah, Kerry A Pierce, Kevin Bullock, Amanda H Anderson, Robert E Gerszten, Harold I Feldman
BACKGROUND: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline, disease progression among individuals with established chronic kidney disease (CKD) has not been rigorously examined. METHODS: We performed a nested case-control study of rapid CKD progression in the Chronic Renal Insufficiency Cohort Study, profiling baseline plasma from 200 individuals each with eGFR slope <-3 ml/min/1...
2016: American Journal of Nephrology
Meenal P Ullewar, Sudhir N Umathe
The present study was carried out to find out the effect of leuprolide, a gonadotropin-releasing hormone (GnRH) receptor agonist, on l-arginine induced immunosuppression, and relates with brain and thymus levels of nitric oxide (NO). Further, the effect of leuprolide was studied in sham operated, ovariectomized and castrated mice to understand the role of sex steroids in l-arginine induced immunosuppression. Treatment with l-arginine (250, 500, 1000 mg/kg/i.p. for 7 days) increased brain and thymus levels of NO; measured by using 'NO Measuring Instrument' (Innovative Instruments Inc...
July 1, 2016: Nitric Oxide: Biology and Chemistry
Christopher J Tyler, Tom Reeve, Gary J Hodges, Stephen S Cheung
BACKGROUND: Exercise performance and capacity are impaired in hot, compared to temperate, conditions. Heat adaptation (HA) is one intervention commonly adopted to reduce this impairment because it may induce beneficial exercise performance and physiological and perceptual adaptations. A number of investigations have been conducted on HA but, due to large methodological differences, the effectiveness of different HA regimens remain unclear. OBJECTIVES: (1) To quantify the effect of different HA regimens on exercise performance and the physiological and perceptual responses to subsequent heat exposure...
April 22, 2016: Sports Medicine
Kosuke Motoki, Motoaki Sugiura, Hikaru Takeuchi, Yuka Kotozaki, Seishu Nakagawa, Ryoichi Yokoyama, Ryuta Kawashima
Plasma oxytocin (OT) and arginine vasopressin (AVP) are associated with individual differences in emotional responses and behaviors. The amygdala is considered to be an important brain region for regulating emotion-based behavior, with OT and AVP modulating activity in the amygdala during the processing of negative emotions. In particular, increased OT levels may diminish amygdala activation (anxiolytic effects) and enhanced AVP levels may augment amygdala activation (anxiogenic effects) when negative emotions are processed...
2016: Frontiers in Psychology
Akar Karakoç, Arzu Sahin, Elif Simsek Polat, Elvin Aliyev, Abdulkadir Yildirim, Nuri Bakan, Eda Dokumacioglu
AIMS: Type 2 diabetes mellitus (T2DM) is a metabolic and chronic disease which is characterized by hyperglycemia, and that is the major causes of various micro and macrovascular complications. Asymmetrical dimethylarginine (ADMA), formed by the hydrolysis of proteins containing methylated arginine residues, is an endogenous inhibitor of nitric oxide synthase (NOS), which oxidize l-arginine to citruline and nitric oxide (NO), related to hyperinsulinaemia and hyperlipidaemia. Apelin is a recently discovered peptide, present in a number of tissues and play role in insulin sensitivity improvement...
April 2016: Diabetes & Metabolic Syndrome
R L Santos, J T Lima, W N Rouver, M R Moysés
The relaxation of coronary arteries by estrogens in the coronary vascular beds of naive and hypertensive rats has been well described. However, little is known about this action in gonadectomized rats. We investigated the effect of 17-ß-estradiol (E2) in coronary arteries from gonadectomized rats, as well as the contributions of endothelium-derived factors and potassium channels. Eight-week-old female and male Wistar rats weighing 220-300 g were divided into sham-operated and gonadectomized groups (n=9-12 animals per group)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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