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https://www.readbyqxmd.com/read/29146252/the-outer-membrane-protein-oprf-and-the-sigma-factor-sigx-regulate-antibiotic-production-in-pseudomonas-fluorescens-2p24
#1
Xu Li, Gao-Qi Gu, Wei Chen, Li-Juan Gao, Xue-Hong Wu, Li-Qun Zhang
Pseudomonas fluorescens 2P24 produces 2,4-diacetylphloroglucinol (2,4-DAPG) as the major antibiotic compound that protects plants from soil-borne diseases. Expression of the 2,4-DAPG biosynthesis enzymes, which are encoded by the phlACBD locus, is under the control of a delicate regulatory network. In this study, we identified a novel role for the outer membrane protein gene oprF, in negatively regulating the 2,4-DAPG production by using random mini-Tn5 mutagentsis. A sigma factor gene sigX was located immediately upstream of the oprF gene and shown to be a positive regulator for oprF transcription and 2,4-DAPG production...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29139483/surface-enhanced-raman-spectroscopy-bottlenecks-and-future-directions
#2
Rajapandiyan Panneerselvam, Guo-Kun Liu, Yao-Hui Wang, Jun-Yang Liu, Song-Yuan Ding, Jian-Feng Li, De-Yin Wu, Zhong-Qun Tian
In this feature article, we discuss in detail developmental bottleneck issues in Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades. We divide SERS research into two different directions with different targets. Fundamental research is extending the limits of SERS to single-molecule, sub-nanometer resolution and femtosecond processes. In contrast, practical research is expanding the range of applications with the aim of providing versatile analytical tools for surface, materials, life, environmental, forensic and food sciences and also commercial instruments for use in daily life...
November 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29137317/mcl-1-stabilization-confers-resistance-to-taxol-in-human-gastric-cancer
#3
Wu Shuang, Lili Hou, Yan Zhu, Qun Li, Wanglai Hu
Taxol has been extensively used as an antineoplastic drug to treat human gastric cancer. However, the acquired drug resistance invariably develops and greatly limits the therapeutic efficacy of Taxol. Identification of the underlying resistance mechanisms may inform the development of new therapies of gastric cancers to Taxol treatment. Here we report that upregulation of Mcl-1 (Myeloid cell leukemia-1) confers acquired resistance to Taxol in human gastric cancer. Mcl-1 is shown to be stabilized in Taxol -resistant gastric cancer cells because of the hyper-activation of the PI3K/Akt signaling pathway...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134450/comorbidity-burden-of-dementia-a-hospital-based-retrospective-study-from-2003-to-2012-in-seven-cities-in-china
#4
Qing-Hua Wang, Xin Wang, Xian-Le Bu, Yan Lian, Yang Xiang, Hong-Bo Luo, Hai-Qiang Zou, Jie Pu, Zhong-He Zhou, Xiao-Ping Cui, Qing-Song Wang, Xiang-Qun Shi, Wei Han, Qiang Wu, Hui-Sheng Chen, Hang Lin, Chang-Yue Gao, Li-Li Zhang, Zhi-Qiang Xu, Meng Zhang, Hua-Dong Zhou, Yan-Jiang Wang
Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease (AD), vascular dementia (VaD), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January 2003 to December 2012. The Charlson Comorbidity Index (CCI) was used to evaluate the comorbidity burden of the patients with dementia...
November 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29115537/lncrna-plncrna%C3%A2-1-regulates-proliferation-and-differentiation-of-hair-follicle-stem-cells-through-tgf%C3%A2-%C3%AE-1%C3%A2-mediated-wnt-%C3%AE-%C3%A2-catenin-signal-pathway
#5
Yuan Si, Jingzhu Bai, Jiang Wu, Qun Li, You Mo, Ruihua Fang, Wei Lai
The present study demonstrated that hair follicle stem cells (HFSc) have multidirectional differentiation potential and participate in skin wound healing processes. Long non‑coding RNAs (lncRNAs) are defined as non‑protein coding transcripts longer than 200 nucleotides, which are important in the proliferation and differentiation of cells. The purpose of the present study was to investigate the role of PlncRNA‑1 in the proliferation and differentiation of HFSc. Results revealed that PlncRNA‑1, transforming growth factor (TGF)‑β1, Wnt and β‑catenin expression levels were significantly downregulated in HFSc...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115406/berberine-prevents-the-apoptosis-of-mouse-podocytes-induced-by-traf5-overexpression-by-suppressing-nf-%C3%AE%C2%BAb-activation
#6
Feng Wu, Dong-Sheng Yao, Tian-Ying Lan, Chen Wang, Jian-Dong Gao, Li-Qun He, Di Huang
Berberine (BBR) has previously been found to exert beneficial effects on renal injury in experimental rats. However, the mechanisms underlying these effects are not yet fully understood. Tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) has been demonstrated to mediate the activation of nuclear factor-κB (NF-κB), which has been implicated in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to investigate the effects of BBR on kidney injury and the activation of the NF-κB signaling pathway in mouse podocytes...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29113206/nuclear-paraspeckle-assembly-transcript-1-promotes-the-metastasis-and-epithelial-mesenchymal-transition-of-hepatoblastoma-cells-by-inhibiting-mir-129-5p
#7
Ming-Cui Fu, Li-Qun Yuan, Ting Zhang, Xiang-Ming Yan, Yun Zhou, Hong-Liang Xia, Yi Wu, Li-Xiao Xu, Xu Cao, Jian Wang
The abnormal expression of nuclear paraspeckle assembly transcript 1 (NEAT1) may serve critical functions for the development and progression of various types of human tumor. However, the expression and biological function of NEAT1 in hepatoblastoma (HB) and the underlying mechanisms for the function of NEAT1 in HB remain largely uncharacterized. In the present study, the results of reverse transcription-quantitative polymerase chain reaction revealed that the expression of NEAT1 was significantly elevated in HB tissues...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108981/outcomes-of-per-oral-endoscopic-myotomy-for-treatment-of-esophageal-achalasia-with-a-median-follow-up-of-49-months
#8
Quan-Lin Li, Qiu-Ning Wu, Xiao-Cen Zhang, Mei-Dong Xu, Wei Zhang, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Ping-Hong Zhou
BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) has received wide acceptance as a highly effective and safe treatment for esophageal achalasia. Short-term and small-scale studies are ample but long-term large-scale studies are few. The aim of the study was to systematically analyze our long-term results of POEM, with particular emphasis on POEM failures and associated risk factors. METHODS: This is a single-center study. Consecutive POEM patients between August 2010 and December 2012 were included...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29099685/gestational-age-and-childhood-leukemia-a-meta-analysis-of-epidemiologic-studies
#9
Yang-Feng Wang, Li-Qun Wu, Yi-Ni Liu, Yong-Yi Bi, Hong Wang
OBJECTIVE: An increasing amount of evidence shows that childhood leukemia is initiated in utero. Birth characteristics initiated in utero, such as gestational age, may play a role in leukemogenesis. The purpose of our meta-analysis is to explore the association between gestational age and childhood leukemia. METHODS: Relevant studies up to 21 April 2017 were collected by searching PubMed and EMBASE databases. Subgroup analysis, sensitivity analysis and publication bias assessment were conducted...
November 3, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29094217/correction-to-dabigatran-induced-massive-spontaneous-hemothorax
#10
Jing Huang, Wei Lin, Dan Lv, Li Yu, Lun Wu, Haiying Jin, Zaichun Deng, Qunli Ding
Page 3, Table 2, 'Renal function indexes at different dates after admission': The cell entry in column 2, detailing the patient's urea concentration (μmol/L) on Day 1.
November 1, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29081344/diagnostic-value-of-cerebrospinal-fluid-t-spot-tb-for-tuberculousis-meningitis-in-china
#11
Xue Lian Li, Na Xie, Song Wang Wang, Qian Hong Wu, Yan Ma, Wei Shu, Hong Mei Chen, Li Qun Zhang, Xiao Guang Wu, Li Ping Ma, Nan Ying Che, Meng Qiu Gao
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT...
September 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29077062/krishnolides-a-d-new-2-ketokhayanolides-from-the-krishna-mangrove-xylocarpus-moluccensis
#12
Qun Zhang, Tirumani Satyanandamurty, Li Shen, Jun Wu
Four new khayanolide-type limonoids with a 2-carbonyl group, named krishnolides A-D (1-4), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the mangrove swamp of Krishna estuary, Andhra Pradesh. The relative and absolute configurations of these compounds were established by HR-ESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with CuKα radiation, and experimental electronic circular dichroism (ECD) spectra. Krishnolides A-D are unusual khayanolides containing two large ester substituents of five or four carbon atoms at the C-3 and C-30 positions, respectively...
October 27, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29073721/microrna-381-induced-down-regulation-of-cxcr4-promotes-the-proliferation-of-renal-tubular-epithelial-cells-in-rat-models-of-renal-ischemia-reperfusion-injury
#13
Gui-Hong Zheng, Xin Wen, Yong-Jian Wang, Xin-Rui Han, Qun Shan, Wang Li, Tian Zhao, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aims to explore whether microRNA-381 (miR-381) mediating CXCR4 affects the renal tubular epithelial cells (RTEC) of renal ischemia reperfusion (I/R) injury. Forty-eight rats were assigned into the I/R (n = 24, successfully established as I/R model) and sham (n = 24) groups. After collecting kidney tissues, immunohistochemistry and microvascular density (MVD) counting were conducted for CXCR4 positive expression and MVD numbers. RTECs were assigned into the sham, blank, negative control (NC), miR-381 mimics, miR-381 inhibitor, si-CXCR4, and miR-381 inhibitor + si-CXCR4 groups...
October 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29070470/-association-between-hypertriglyceridemic-waist-to-height-ratio-phenotype-and-chronic-kidney-disease-in-a-community-population-in-south-china-a-cross-sectional-study
#14
Xiao-Fei Shao, Bi-Fang Wu, Ai-Qun Liu, Bin Li, Yong-Qiang Li, Qin Zhou, He-Qun Zou
OBJECTIVE: To investigate the relationship between hypertriglyceridemic waist to height ratio phenotype (HWHtR) and chronic kidney disease (CKD) in a community population in South China. METHODS: A cross sectional study was conducted among 2142 residents in Zhuhai (Guangdong Province, China) from June to October of 2012. The HWHtR phenotype was defined as a waist to height ratio(WHtR) ≥0.55 and triglyceride level ≥2.0 mmol/L, based on which the participants were divided into HWHtR group and nonHWHtR group...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29050307/lncshrg-promotes-hepatocellular-carcinoma-progression-by-activating-hes6
#15
Ying-Chen Xu, Chao-Jie Liang, Dong-Xin Zhang, Guan-Qun Li, Xia Gao, Jian-Zhu Fu, Feng Xia, Jia-Jun Ji, Li-Jun Zhang, Guang-Ming Li, Ji-Xiang Wu
Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, lncSHRG recruits SATB1 to bind to HES6 promoter and initiates HES6 expression. HES6, which is highly expressed in hepatocellular carcinoma, promotes tumor cell proliferation...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044943/fast-lithium-ion-transportation-in-crystalline-polymer-electrolytes
#16
Xiao-Bin Fu, Guang Yang, Jin-Ze Wu, Jianchen Wang, Qun Chen, Yefeng Yao
Fast lithium-ion transportation is found in the crystalline polymer electrolytes, α-CD-PEOn/Li+ (n = 12, 40), prepared by self-assembly of α-cyclodextrin (CD), polyethylene oxide (PEO) and Li+ salts. A detailed solid-state NMR study combined with X-ray diffraction technique reveals the unique structural features of the samples, that is, a) the tunnel structure formed by the assembled CDs, providing the ordered long-range pathway for Li+ ion transportation; b) the all-trans conformational sequence of the PEO chains in the tunnels, attenuating significantly the coordination between Li+ and the EO segments...
October 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29040850/biosynthesis-of-tert-butyl-3r-5s-6-chloro-3-5-dihydroxyhexanoate-by-carbonyl-reductase-from-rhodosporidium-toruloides-in-mono-and-biphasic-media
#17
Zhi-Qiang Liu, Lin Wu, Ling Zheng, Wen-Zhong Wang, Xiao-Jian Zhang, Li-Qun Jin, Yu-Guo Zheng
tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate ((3R,5S)-CDHH) is the key intermediate for synthesis of atorvastatin and rosuvastatin. Carbonyl reductase exhibits excellent activity toward tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate ((S)-CHOH) to synthesize (3R,5S)-CDHH. In this study, a whole cell biosynthesis reaction system to produce (3R,5S)-CDHH was constructed in organic solvents. A solution of 10% (v/v) Tween-80 was introduced to the reaction system as a co-solvent, which greatly enhanced biotransformation process, giving 98...
October 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29039477/comprehensive-analysis-of-circrna-expression-profiles-in-humans-by-raise
#18
Lin Li, Yong-Chang Zheng, Masood Ur Rehman Kayani, Wen Xu, Guan-Qun Wang, Pei Sun, Ning Ao, Li-Na Zhang, Zhao-Qi Gu, Liang-Cai Wu, Hai-Tao Zhao
Circular RNAs (circRNAs) are pervasively expressed circles of non‑coding RNAs. Even though many circRNAs have been reported in humans, their expression patterns and functions remain poorly understood. In this study, we employed a pipeline named RAISE to detect circRNAs in RNA‑seq data. RAISE can fully characterize circRNA structure and abundance. We evaluated inter-individual variations in circRNA expression in humans by applying this pipeline to numerous non‑poly(A)-selected RNA‑seq data. We identified 59,128 circRNA candidates in 61 human liver samples, with almost no overlap in the circRNA of the recruited samples...
December 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29035567/hit-to-lead-optimization-and-discovery-of-5-5-1-1-biphenyl-4-yl-6-chloro-1h-benzo-d-imidazol-2-yl-oxy-2-methylbenzoic-acid-mk-3903-a-novel-class-of-benzimidazole-based-activators-of-amp-activated-protein-kinase
#19
Ping Lan, F Anthony Romero, Dariusz Wodka, Andrew J Kassick, Qun Dang, Tony Gibson, Daniel Cashion, Gaochao Zhou, Yuli Chen, Xiaoping Zhang, Aihua Zhang, Ying Li, Maria E Trujillo, Qing Shao, Margaret Wu, Shiyao Xu, Huaibing He, Deidre MacKenna, Jocelyn Staunton, Kevin T Chapman, Ann Weber, Iyassu K Sebhat, Gergely M Makara
AMP-activated protein kinase (AMPK) plays an essential role as a cellular energy sensor and master regulator of metabolism in eukaryotes. Dysregulated lipid and carbohydrate metabolism resulting from insulin resistance leads to hyperglycemia, the hallmark of type 2 diabetes mellitus (T2DM). While pharmacological activation of AMPK is anticipated to improve these parameters, the discovery of selective, direct activators has proven challenging. We now describe a hit-to-lead effort resulting in the discovery of a potent and selective class of benzimidazole-based direct AMPK activators, exemplified by 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid, 42 (MK-3903)...
October 25, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28991187/peptides-from-colochirus-robustus-enhance-immune-function-via-activating-cd3%C3%AE-and-zap-70-mediated-signaling-in-c57bl-6-mice
#20
Xiaogang Du, Fangliang Lian, Yunkun Li, Dong Li, Dayong Wu, Qunli Feng, Zhijiang Feng, Yun Li, Guixian Bu, Fengyan Meng, Xiaohan Cao, Zhiyu Chen, Xianyin Zeng
Colochirus robustus, a species of sea cucumber, has long been used in East and Southeast Asia as nutritious food as well as for certain medicinal purpose. Studies have shown a number of biological functions associated with consumption of sea cucumber, many of which are attributed to its major component, sea cucumber peptides (SCP). However, how SCP impacts immune system, which is critical for host defense, has not been defined. To address this issue, in the present study, we conducted comprehensive analysis of immune function after oral administration of SCP (0, 25, 50, and 75 mg/kg body weigh) for eight weeks in C57BL/6 mice...
October 8, 2017: International Journal of Molecular Sciences
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