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https://www.readbyqxmd.com/read/29275628/plasmon-enhanced-ultra-sensitive-surface-analysis-using-ag-nanoantenna
#1
Chao-Yu Li, Jinhong Gao, Jun Yi, Xia-Guang Zhang, Xiao-Dan Cao, Meng Meng, Chen Wang, Ya-Ping Huang, San-Jun Zhang, De-Yin Wu, Chuan-Liu Wu, Jian-Hua Xu, Zhong-Qun Tian, Jian-Feng Li
Raman scattering and fluorescence spectroscopy permeate analytic science and are featured in the family of plasmon-enhanced spectroscopy (PES). However, the modest enhancement of plasmon-enhanced fluorescence (PEF) signifi-cantly limits the sensitivity in surface analysis and material characterization. Herein, we report a Ag nanoantenna plat-form, which fulfills simultaneous ultra-strong emission (an optimum average enhancement of 105-fold) and ultra-fast emission rate (~280-fold) in PES. For the application in surface science, this platform has been examined with diverse fluorophores...
December 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29246011/network-meta-analysis-of-the-efficacy-of-first-line-chemotherapy-regimens-in-patients-with-advanced-colorectal-cancer
#2
Dong-Mei Wu, Yong-Jian Wang, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Xin-Rui Han, Xin Wen, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Ya-Xing Bao, Hai-Juan Xiao, Lin Yang, Jun Lu, Yuan-Lin Zheng
This network meta-analysis compared the short-term and long-term efficacies of first-line chemotherapy regimens in patients with advanced colorectal cancer (CRC). The 10 regimens included folinic acid + 5-fluorouracil + oxaliplatin (FOLFOX), folinic acid + 5-fluorouracil + irinotecan (FOLFIRI), folinic acid + 5-fluorouracil + gemcitabine (FFG), folinic acid + 5-fluorouracil + trimetrexate (FFT), folinic acid + 5-fluorouracil (FF), irinotecan + oxaliplatin (IROX), raltitrexed + oxaliplatin (TOMOX), folinic acid + tegafur-uracil (FTU), raltitrexed, and capecitabine...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245973/microrna-433-inhibits-oral-squamous-cell-carcinoma-cells-by-targeting-fak
#3
Yong-Jian Wang, Zi-Feng Zhang, Shao-Hua Fan, Juan Zhuang, Qun Shan, Xin-Rui Han, Xin Wen, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Bin Qiao, Qian Tao, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
We investigated the involvement of microRNA-433 (miR-433) in the proliferation, migration, and invasiveness of oral squamous cell carcinoma (OSCC). Totally 108 OSCC tissues and adjacent normal tissues from patients with OSCC were collected. Also, transplanted tumor formation experiment in nude mice was conducted to verify the effect of miR-433 and FAK on subcutaneous transplanted tumor. The CD44+ stem cell from SCC-9 were collected and assigned into the blank, miR-433 mimics, mimics control, miR-433 inhibitors, inhibitors control, siFAK and miR-433 inhibitors + siFAK groups...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228570/keratin-8-reduces-colonic-permeability-and-maintains-gut-microbiota-homeostasis-protecting-against-colitis-and-colitis-associated-tumorigenesis
#4
Chao Liu, En-Dong Liu, Yun-Xiao Meng, Xiao-Ming Dong, Ya-Lan Bi, Huan-Wen Wu, Yan-Chao Jin, Ke Zhao, Jian-Jie Li, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Xiao-Ming Yang, Chang-Yan Li
Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the colon during DSS-induced colitis and AOM/DSS-induced colitis-associated colorectal cancer (CAC) development. In human patients with colon cancer, CK8 is downregulated. Using CK8 heterozygous knockout mice (CK8+/-), we found that CK8+/- mice are highly susceptible to DSS-induced colitis and more prone to AOM/DSS-induced CAC than wild type (WT) mice...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227541/protective-effects-of-microrna-431-against-cerebral-ischemia-reperfusion-injury-in-rats-by-targeting-the-rho-rho-kinase-signaling-pathway
#5
Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study investigates the protective effects of miR-431 against cerebral ischemia-reperfusion injury through the Rho/Rho-kinase signaling pathway. SD rats were randomly classified into normal, sham and model (middle cerebral artery occluded) groups. Rho expression and cerebral infarction were visualized by immunohischemistry and TTC staining, respectively. qRT-PCR and western blotting were used to measure mRNA and protein expression of miR-431 and Rho/Rho-kinase signaling pathway-related genes. Hippocampal neurons were extracted and assigned into normal, blank, negative control (NC), miR-431 mimics, miR-431 inhibitors, siRNA-Rho and miR-431 inhibitors + siRNA-Rho groups...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29222028/sodium-butyrate-enhanced-physical-barrier-function-referring-to-nrf2-jnk-and-mlck-signaling-pathways-in-the-intestine-of-young-grass-carp-ctenopharyngodon-idella
#6
Pei Wu, Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Fei Xie, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Juan Yang, Yong-An Zhang, He-Qun Shi, Lin Feng
This study evaluated the effect of dietary sodium butyrate (SB) supplementation on the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). The fish were fed one powdery sodium butyrate (PSB) diet (1000.0 mg kg-1 diet) and five graded levels of microencapsulated sodium butyrate (MSB) diets: 0.0 (control), 500.0, 1000.0, 1500.0 and 2000.0 mg kg-1 diet for 60 days. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila to explore the effect of SB supplementation on intestinal physical barrier function and the potential mechanisms in fish...
December 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29215699/lncrna-linc00880-promotes-cell-proliferation-migration-and-invasion-while-inhibiting-apoptosis-by-targeting-cacng5-through-the-mapk-signaling-pathway-in-spinal-cord-ependymoma
#7
Dong-Mei Wu, Yong-Jian Wang, Xin-Rui Han, Xin Wen, Shan Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Yuan-Lin Zheng
The present study was to investigate the effect of lncRNA LINC00880 targeting CACNG5 on cell proliferation, migration, invasion and apoptosis in spinal cord ependymoma (SCE) through the MAPK signaling pathway. GEO database was used to download gene expression data related with SCE (GSE50161 and GSE66354) and annotation file. LncRNA with differential expression was predicted by Multi Experiment Matrix website (MEM). The target gene was analyzed by KEGG pathway enrichment analysis. SCE tissues and adjacent tissues were collected...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29204120/alternation-of-gut-microbiota-in-patients-with-pulmonary-tuberculosis
#8
Mei Luo, Yong Liu, Pengfei Wu, Dong-Xia Luo, Qun Sun, Han Zheng, Richard Hu, Stephen J Pandol, Qing-Feng Li, Yuan-Ping Han, Yilan Zeng
One-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis), a primary pathogen of the mammalian respiratory system, while about 10% of latent infections progress to active tuberculosis (TB), indicating that host and environmental factors may determine the outcomes such as infection clearance/persistence and treatment prognosis. The gut microbiota is essential for development of host immunity, defense, nutrition and metabolic homeostasis. Thus, the pattern of gut microbiota may contribute to M...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29200264/fully-coated-semitransparent-organic-solar-cells-with-a-doctor-blade-coated-composite-anode-buffer-layer-of-phosphomolybdic-acid-and-pedot-pss-and-a-spray-coated-silver-nanowire-top-electrode
#9
J I Guoqi, Yiying Wang, Qun Luo, Kang Han, Menglan Xie, Lianping Zhang, Na Wu, Jian Lin, Shugang Xiao, Yanqing Li, Liqiang Luo, Chang-Qi Ma
Aiming to realize high performance semitransparent fully coated organic solar cells, printable electrode buffer layers and top electrodes are two important key technologies. An ideal ink for the preparation of the electrode buffer layer for printed top electrodes should have good wettability and negligible solvent corrosion to the underlying layer. This work reports a novel organic-inorganic composite of phosphomolybdic acid (PMA) and PEDOT:PSS that features excellent wettability with the active layer and printed top Ag nanowires, and high resistibility to solvent corrosion...
December 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29190996/surgical-resection-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-in-the-asia-pacific-region-beyond-the-barcelona-clinic-liver-cancer-treatment-algorithms-a-review-and-update
#10
REVIEW
Jia-Zhou Ye, Yan-Yan Wang, Tao Bai, Jie Chen, Bang-De Xiang, Fei-Xiang Wu, Le-Qun Li
Portal vein tumor thrombus (PVTT) usually worsens prognosis of hepatocellular carcinoma (HCC), as characterized by aggressive disease progression, impaired liver function and tolerance to treatment. Conventionally, the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) accepted the Barcelona Clinical Liver Cancer (BCLC) treatment algorithms, identifying PVTT as an absolute contra-indication of surgical resection for HCC. HCC-PVTT patients are offered sorafenib as the standard treatment...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29187735/mitochondrial-genomes-uncover-the-maternal-history-of-the-pamir-populations
#11
Min-Sheng Peng, Weifang Xu, Jiao-Jiao Song, Xing Chen, Xierzhatijiang Sulaiman, Liuhong Cai, He-Qun Liu, Shi-Fang Wu, Yun Gao, Najmudinov Tojiddin Abdulloevich, Manilova Elena Afanasevna, Khudoidodov Behruz Ibrohimovich, Xi Chen, Wei-Kang Yang, Miao Wu, Gui-Mei Li, Xing-Yan Yang, Allah Rakha, Yong-Gang Yao, Halmurat Upur, Ya-Ping Zhang
The Pamirs, among the world's highest mountains in Central Asia, are one of homelands with the most extreme high altitude for several ethnic groups. The settlement history of modern humans on the Pamirs remains still opaque. Herein, we have sequenced the mitochondrial DNA (mtDNA) genomes of 382 individuals belonging to eight populations from the Pamirs and the surrounding lowlands in Central Asia. We construct the Central Asian (including both highlanders and lowlanders) mtDNA haplogroup tree at the highest resolution...
November 29, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29174310/gefitinib-versus-vinorelbine-plus-cisplatin-as-adjuvant-treatment-for-stage-ii-iiia-n1-n2-egfr-mutant-nsclc-adjuvant-ctong1104-a-randomised-open-label-phase-3-study
#12
Wen-Zhao Zhong, Qun Wang, Wei-Min Mao, Song-Tao Xu, Lin Wu, Yi Shen, Yong-Yu Liu, Chun Chen, Ying Cheng, Lin Xu, Jun Wang, Ke Fei, Xiao-Fei Li, Jian Li, Cheng Huang, Zhi-Dong Liu, Shun Xu, Ke-Neng Chen, Shi-Dong Xu, Lun-Xu Liu, Ping Yu, Bu-Hai Wang, Hai-Tao Ma, Hong-Hong Yan, Xue-Ning Yang, Qing Zhou, Yi-Long Wu
BACKGROUND: Cisplatin-based adjuvant chemotherapy is the standard of care for patients with resected stage II-IIIA non-small-cell lung cancer (NSCLC). RADIANT and SELECT trial data suggest patients with EGFR-mutant stage IB-IIIA resected NSCLC could benefit from adjuvant EGFR tyrosine kinase inhibitor treatment. We aimed to compare the efficacy of adjuvant gefitinib versus vinorelbine plus cisplatin in patients with completely resected EGFR-mutant stage II-IIIA (N1-N2) NSCLC. METHODS: We did a randomised, open-label, phase 3 trial at 27 centres in China...
November 21, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29166853/proteomic-insight-into-fruit-set-of-cucumber-cucumis-sativus-l-suggests-the-cues-of-hormone-independent-parthenocarpy
#13
Ji Li, Jian Xu, Qin-Wei Guo, Zhe Wu, Ting Zhang, Kai-Jing Zhang, Chun-Yan Cheng, Pin-Yu Zhu, Qun-Feng Lou, Jin-Feng Chen
BACKGROUND: Parthenocarpy is an excellent agronomic trait that enables crops to set fruit in the absence of pollination and fertilization, and therefore to produce seedless fruit. Although parthenocarpy is widely recognized as a hormone-dependent process, hormone-insensitive parthenocarpy can also be observed in cucumber; however, its mechanism is poorly understood. To improve the global understanding of parthenocarpy and address the hormone-insensitive parthenocarpy shown in cucumber, we conducted a physiological and proteomic analysis of differently developed fruits...
November 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29165238/clusters-of-human-infection-and-human-to-human-transmission-of-avian-influenza-a-h7n9-virus-2013-2017
#14
Lei Zhou, Enfu Chen, Changjun Bao, Nijuan Xiang, Jiabing Wu, Shengen Wu, Jian Shi, Xianjun Wang, Yaxu Zheng, Yi Zhang, Ruiqi Ren, Carolyn M Greene, Fiona Havers, A Danielle Iuliano, Ying Song, Chao Li, Tao Chen, Yali Wang, Dan Li, Daxin Ni, Yanping Zhang, Zijian Feng, Timothy M Uyeki, Qun Li
To detect changes in human-to-human transmission of influenza A(H7N9) virus, we analyzed characteristics of 40 clusters of case-patients during 5 epidemics in China in 2013-2017. Similarities in number and size of clusters and proportion of clusters with probable human-to-human transmission across all epidemics suggest no change in human-to-human transmission risk.
February 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29153589/biocatalytic-hydrolysis-of-chlorinated-nicotinamides-by-a-superior-as-family-amidase-and-its-application-in-enzymatic-production-of-2-chloronicotinic-acid
#15
Ren-Chao Zheng, Jian-Qiang Jin, Zhe-Ming Wu, Xiao-Ling Tang, Li-Qun Jin, Yu-Guo Zheng
2-Chloronicotinic acid (2-CA) is an important building block for a series of agrochemicals and pharmaceuticals. Amidase-catalyzed hydrolysis of 2-chloronicotinamide is one of the most attractive approaches for 2-CA production. However, development of the bioprocess was plagued by low activity of amidase for 2-chloronicotinamide. In this work, an amidase signature (AS) family amidase from Pantoea sp. (Pa-Ami), with superior activity for nicotinamide and its chlorinated derivatives, was exploited and characterized...
November 7, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29151935/comparison-of-combined-transcatheter-arterial-chemoembolization-and-ct-guided-radiofrequency-ablation-with-surgical-resection-in-patients-with-hepatocellular-carcinoma-within-the-up-to-seven-criteria-a-multicenter-case-matched-study
#16
Tao Pan, Lu-Wen Mu, Chun Wu, Xi-Qun Wu, Qian-Kun Xie, Xi-Shan Li, Ning Lyu, Shao-Long Li, Hai-Jing Deng, Zai-Bo Jiang, Ai-Hua Lin, Ming Zhao
Background & Aims: We compared the efficacy of transcatheter arterial chemoembolization (TACE) in combination with CT-guided radiofrequency ablation (RFA) with that of surgical resection (SR) in patients with hepatocellular carcinoma (HCC) within the up-to-seven criteria. Methods: From January 2004 to December 2014, 420 multicenter consecutive patients with HCC who conformed to the up-to-seven criteria and initially received either TACE plus CT-guided RFA (TACE-RFA) or SR were enrolled. A matched cohort composed of 206 patients was selected after adjustment with propensity score matching...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151695/efficacy-of-postoperative-adjuvant-transcatheter-arterial-chemoembolization-in-hepatocellular-carcinoma-patients-with-microvascular-invasion
#17
Jia-Zhou Ye, Jun-Ze Chen, Zi-Hui Li, Tao Bai, Jie Chen, Shao-Liang Zhu, Le-Qun Li, Fei-Xiang Wu
AIM: To investigate the efficacy and safety of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) in preventing tumor recurrence and improving survival in Barcelona Clinic Liver Cancer (BCLC) early (A) and intermediate (B) stage hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). METHODS: A total of 519 BCLC A or B HCC patients treated by liver resection alone or followed by PA-TACE between January 2012 and December 2015 were studied retrospectively...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29150948/methylation-associated-dok1-and-dok2-down-regulation-potential-biomarkers-for-predicting-adverse-prognosis-in-acute-myeloid-leukemia
#18
Pin-Fang He, Zi-Jun Xu, Jing-Dong Zhou, Xi-Xi Li, Wei Zhang, De-Hong Wu, Zhi-Hui Zhang, Xin-Yue Lian, Xin-Yu Yao, Zhao-Qun Deng, Jiang Lin, Jun Qian
DOK-1 and DOK-2 (DOK1/2) are closely related members of downstream of tyrosine kinase (DOK) family genes, which are found to be frequently rearranged in several hematopoietic cancers. However, the clinical implications of DOK1/2 in acute myeloid leukemia (AML) remain largely unknown. To investigate the clinical significance, real-time quantitative PCR (RQ-PCR) was carried out to detect DOK1/2 expressions in 125 de novo AML patients and 28 healthy controls. Real-time quantitative methylation-specific PCR (RQ-MSP) and bisulfite sequencing PCR (BSP) were applied to detect DOK1/2 methylation level and density...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29146252/the-outer-membrane-protein-oprf-and-the-sigma-factor-sigx-regulate-antibiotic-production-in-pseudomonas-fluorescens-2p24
#19
Xu Li, Gao-Qi Gu, Wei Chen, Li-Juan Gao, Xue-Hong Wu, Li-Qun Zhang
Pseudomonas fluorescens 2P24 produces 2,4-diacetylphloroglucinol (2,4-DAPG) as the major antibiotic compound that protects plants from soil-borne diseases. Expression of the 2,4-DAPG biosynthesis enzymes, which are encoded by the phlACBD locus, is under the control of a delicate regulatory network. In this study, we identified a novel role for the outer membrane protein gene oprF, in negatively regulating the 2,4-DAPG production by using random mini-Tn5 mutagentsis. A sigma factor gene sigX was located immediately upstream of the oprF gene and shown to be a positive regulator for oprF transcription and 2,4-DAPG production...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29139483/surface-enhanced-raman-spectroscopy-bottlenecks-and-future-directions
#20
Rajapandiyan Panneerselvam, Guo-Kun Liu, Yao-Hui Wang, Jun-Yang Liu, Song-Yuan Ding, Jian-Feng Li, De-Yin Wu, Zhong-Qun Tian
In this feature article, we discuss in detail developmental bottleneck issues in Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades. We divide SERS research into two different directions with different targets. Fundamental research is extending the limits of SERS to single-molecule, sub-nanometer resolution and femtosecond processes. In contrast, practical research is expanding the range of applications with the aim of providing versatile analytical tools for surface, materials, life, environmental, forensic and food sciences and also commercial instruments for use in daily life...
November 15, 2017: Chemical Communications: Chem Comm
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