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https://www.readbyqxmd.com/read/29785120/association-between-nr5a2-and-the-risk-of-pancreatic-cancer-especially-among-caucasians-a-meta-analysis-of-case-control-studies
#1
Qun Chen, Hao Yuan, Guo-Dong Shi, Yang Wu, Dong-Fang Liu, Yu-Ting Lin, Lei Chen, Wan-Li Ge, Kuirong Jiang, Yi Miao
Background: Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its potential attributing factors, we pooled the updated literatures to evaluate the association between NR5A2 polymorphism and the risk of pancreatic cancer in this meta-analysis...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29782902/five-rare-dimeric-sesquiterpenes-exhibiting-potential-neuroprotection-activity-from-vladimiria-souliei
#2
Zhi-Li Wu, Qun Wang, Hong-Yuan Dong, Hui-liangLi, Shu-Mei Wang, Wei-Dong Zhang
Two rare C32 sesquiterpene lactone dimers, vlasouliolides J-K (1-2), together with three C30 sesquiterpene dimers, vlasoulioliones A-C (3-5), were isolated from Vladimiria souliei. Their chemical structures were elucidated by NMR and MS spectroscopic data. Among them, compounds 1, 3 and 5 were unambiguously established by Cu-Kα X-ray crystallographic analysis. Furthermore, compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC50 value of 2.11 ± 0...
May 18, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29778571/phenylacetylene-bearing-3-4-seco-cleistanthane-diterpenoids-from-the-roots-of-phyllanthus-glaucus
#3
Zhaodi Wu, Yongji Lai, Qing Zhang, Shuangshuang Xie, Mi Zhang, Zhengxi Hu, Xiao-Nian Li, Jianping Wang, Zengwei Luo, Yongbo Xue, Qun Zhou, Hucheng Zhu, Yonghui Zhang
Three new cleistanthane diterpenoids, phyllanglins A-C (1-3), a new natural product, 4-acetyl-bergenin (4), and three known compounds (5-7) were isolated from the roots of Phyllanthus glaucus. Their structures were elucidated by extensive spectroscopic data analyses and single-crystal X-ray diffraction. Phyllanglins A-C were unusual cleistanthane diterpenoids with phenylacetylene moieties, and a plausible biogenetic pathway was proposed to discuss the origins of them. All of the isolates were evaluated for their anti-inflammatory activities...
May 17, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29775272/remarkable-enhancement-in-the-photoelectric-performance-of-uniform-flower-like-mesoporous-fe3o4-wrapped-in-nitrogen-doped-graphene-networks
#4
Jixin Yao, Kang Zhang, Wen Wang, Xueqin Zuo, Qun Yang, Huaibao Tang, Mingzai Wu, Guang Li
The porous structure and excellent specific surface area are superior for use as a counter electrode (CE) material. In addition, N-doped graphene possesses a remarkable electron-transfer pathway and many active sites. Therefore, a novel idea is to wrap uniform flower-like mesoporous Fe3O4 (Fe3O4UFM) in a N-doped graphene (N-RGO) network structure to enhance the power conversion efficiency (PCE). The hybrid materials of Fe3O4UFM@N-RGO are first used as a CE in dye-sensitized solar cells (DSSCs), showing a preeminent conductive interconnected 3D porous structure with more catalytic activity sites and a better ability for and a faster reaction rate of charge transfer, resulting in quicker reduction of I_3^- than Pt...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29771527/protoilludane-illudalane-and-botryane-sesquiterpenoids-from-the-endophytic-fungus-phomopsis-sp-tj507a
#5
Shuangshuang Xie, Ye Wu, Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue, Yonghui Zhang
To explore the chemical diversity of metabolites from endophytic fungi, the strain Phomopsis sp. TJ507A, isolated from the medicinal plant Phyllanthus glaucus, was investigated. A 2,3- seco-protoilludane-type sesquiterpenoid (1), eight protoilludane-type sesquiterpenoids (2-9), four illudalane-type sesquiterpenoids (10a/10b, 11, and 12), and a botryane-type sesquiterpenoid (13) in addition to seven known sesquiterpenoids (14-20) were identified from the liquid culture of the fungus. Structures of the isolated compounds, including their absolute configurations, were elucidated based on extensive spectroscopic analyses, a modified Mosher analysis, electronic circular dichroism (ECD) calculations, and [Rh2 (OCOCF3 )4 ]-induced ECD spectra as well as X-ray crystallographic analyses...
May 17, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29764506/cardiotoxicity-of-5-fluorouracil-and-capecitabine-in-chinese-patients-a-prospective-study
#6
Jianjun Peng, Chao Dong, Chang Wang, Weihua Li, Hao Yu, Min Zhang, Qun Zhao, Bo Zhu, Jun Zhang, Wenliang Li, Fenghua Wang, Qiong Wu, Wenhao Zhou, Ying Yuan, Meng Qiu, Gong Chen
BACKGROUND: 5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date. In the present study, we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU- and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China...
May 11, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764487/effect-of-induction-chemotherapy-with-cisplatin-fluorouracil-with-or-without-taxane-on-locoregionally-advanced-nasopharyngeal-carcinoma-a-retrospective-propensity-score-matched-analysis
#7
Guo-Ying Liu, Xing Lv, Yi-Shan Wu, Min-Jie Mao, Yan-Fang Ye, Ya-Hui Yu, Hu Liang, Jing Yang, Liang-Ru Ke, Wen-Ze Qiu, Xin-Jun Huang, Wang-Zhong Li, Xiang Guo, Yan-Qun Xiang, Wei-Xiong Xia
BACKGROUND: Available data in the literature comparing different induction chemotherapy (IC) regimens on locoregionally advanced nasopharyngeal carcinoma (NPC) are scarce. The purpose of the present study was to evaluate the outcomes of locoregionally advanced NPC patients who were treated with taxane, cisplatin and 5-fluorouracil (TPF) or cisplatin and 5-fluorouracil (PF) as IC followed by concurrent chemoradiotherapy (CCRT). METHODS: In total, 1879 patients with locoregionally advanced NPC treated with IC and CCRT from a prospectively maintained database were included in the present observational study...
May 10, 2018: Cancer communications
https://www.readbyqxmd.com/read/29745151/-effect-of-nitrogen-management-modes-on-grain-yield-nitrogen-use-efficiency-and-light-use-efficiency-of-wheat
#8
Xiao Li Wu, Chao Su Li, Yong Lu Tang, Yu Bin Liu, Bo Qun Li, Gao Qiong Fan, Tao Xiong
A nitrogen management experiment with three nitrogen levels (0, 120, and 180 kg·hm-2 , namely N0 , N120 , N180 ) and three nitrogen allocation modes (NA : base fertilizer 100%; NB : base fertilizer 70% + seedling fertilizer 30%; NC : base fertilizer 60% + jointing fertilizer 40%) was conducted at four sites (Chongqing, Renshou, Guanghan and Xichang) during two consecutive years, the SPAD value, canopy photosynthetic rate (CAP), photosynthetically active radia-tion (PAR) interception efficiency and grain yield were determined, and the nitrogen use efficiency and PAR use efficiency were calculated...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29742652/the-use-of-a-honeycomb-technique-combined-with-ultrasonic-aspirators-and-indocyanine-green-fluorescence-angiography-for-a-superthin-anterolateral-thigh-flap-a-pilot-study
#9
Song Fan, Han-Qing Zhang, Qun-Xing Li, Tian Tian, Wei-Xiong Chen, Guo-Kai Pan, Michael Ho-Young Ahn, Sheng Sun, Bing-Hao Wu, Jin-Song Li
BACKGROUND: Harvesting an optimally thinned anterolateral thigh flaps (ALTFs) is a challenge in overweight individuals and in the Western population. Here, we describe a novel honeycomb technique to achieve a superthin ALTF in overweight patients. METHODS: Forty patients with a body mass index(BMI) >25 kg/m who required a thinned ALTF for reconstruction were randomly assigned to a honeycomb technique (HCT) group or a microdissection technique (MDT) group. Patients in the HCT group received cavitron ultrasonic surgical aspiration (CUSA) to thin the flaps, and flap thinning was performed with a conventional MDT in the MDT group...
May 2, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29742504/mir-142-3p-enhances-cell-viability-and-inhibits-apoptosis-by-targeting-cdkn1b-and-timp3-following-sciatic-nerve-injury
#10
Dong-Mei Wu, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Yuan-Lin Zheng
BACKGROUND/AIMS: MiRNAs are involved in phenotype modulation of neural cells after peripheral nerve injury. However, the roles of miRNAs on the survival of dorsal root ganglion (DRG) neurons have not yet been fully understood. METHODS: In this study, the expression of miR-142-3p was measured in rat DRGs (L4-L6) during the initial 24 hours post sciatic nerve transection by microarray profiling and quantitative PCR. The functional assays including the cell viability, colony formation, cell cycle and apoptosis assays were performed in miR-142-3p mimic or inhibitor transfected cell lines...
May 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29722294/gold-nanochestnut-arrays-as-ultra-sensitive-sers-substrate-for-detecting-trace-pesticide-residue
#11
Fei Geng, Huaping Zhao, Qun Fu, Yan Mi, Likun Miao, Wei Li, Yulian Dong, Minghong Wu, Yong Lei
Surface-enhanced Raman spectroscopy (SERS) enables the rapid identification and detection of trace pesticide residues presented in trace amounts in the environment and foods. Herein, a facile approach to fabricate unique gold nanochestnuts (GNCs) as ultra-sensitive SERS substrate for detecting trace pesticide residues has been developed based on anodic aluminum oxide (AAO) templates. Gold GNCs are synthesized through galvanic replacement of silver on the top of nickel nanorod arrays. The as-prepared GNCs have well controlled structural parameters and importantly with unique anisotropic morphologies, benefiting to the enhancement in SERS performance...
May 3, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29710495/phosphodiesterase-4-inhibition-confers-a-neuroprotective-efficacy-against-early-brain-injury-following-experimental-subarachnoid-hemorrhage-in-rats-by-attenuating-neuronal-apoptosis-through-the-sirt1-akt-pathway
#12
Qun Li, Yucong Peng, Linfeng Fan, Hangzhe Xu, Pingyou He, Shenglong Cao, Jianru Li, Ting Chen, Wu Ruan, Gao Chen
Phosphodiesterase-4 (PDE4) plays a fundamental role in a range of central nervous system (CNS) insults, however, the role of PDE4 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains unclear. The current study was designed to investigate the role of PDE4 in EBI after SAH and explore the potential mechanism. The SAH model in Sprague-Dawley rat was established by endovascular perforation process. Rats were randomly divided into: sham group, SAH?+?vehicle group, SAH?+?rolipram (PDE4 inhibitor) group, SAH?+?rolipram?+?sirtinol (SIRT1 inhibitor) group and SAH?+?rolipram+MK2206 (Akt inhibitor) group...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705802/salidroside-protection-against-oxidative-stress-injury-through-the-wnt-%C3%AE-catenin-signaling-pathway-in-rats-with-parkinson-s-disease
#13
Dong-Mei Wu, Xin-Rui Han, Xin Wen, Shan Wang, Shao-Hua Fan, Juan Zhuang, Yong-Jian Wang, Zi-Feng Zhang, Meng-Qiu Li, Bin Hu, Qun Shan, Chun-Hui Sun, Jun Lu, Yuan-Lin Zheng
BACKGROUND/AIMS: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, and recent studies suggested that oxidative stress (OS) contributes to the cascade that leads to dopamine cell degeneration in PD. In this study, we hypothesized that salidroside (SDS) offers protection against OS injury in 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats as well as the underlying mechanism. METHODS: SDS and LiCl (activators of the Wnt/β-catenin signaling pathway) administration alone and in combination with 6-OHDA injection in rats was performed 3 days before modeling for 17 consecutive days to verify the regulatory mechanism by which SDS affects the Wnt/β-catenin signaling pathway as well as to evaluate the protective effect of SDS on PD in relation to OS in vivo...
April 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29701296/repression-of-microrna-382-inhibits-glomerular-mesangial-cell-proliferation-and-extracellular-matrix-accumulation-via-foxo1-in-mice-with-diabetic-nephropathy
#14
Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
OBJECTIVES: Diabetic nephropathy (DN) is a nerve damaging disorder, characterized by glomerular mesangial cell expansion and accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate mesangial cell proliferation and ECM accumulation when promoting or suppressing endogenous miR-382 in glomerular mesangial cells of DN. MATERIALS AND METHODS: Model establishment consisted of DN induction by streptozotocin (STZ) in mice. The underlying regulatory mechanisms of miR-382 were analysed in concert with the treatment of miR-382 mimics, miR-382 inhibitors or siRNA against FoxO1 in cultured glomerular mesangial cells isolated from DN mice...
April 27, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29691838/ros-autophagy-pathway-mediates-monocytes-human-umbilical-vein-endothelial-cells-adhesion-induced-by-apelin-13
#15
Meiqing Liu, Hening Li, Qun Zhou, Hong Zhao, Deguan Lv, Jiangang Cao, Jinyong Jiang, Mingzhu Tang, Di Wu, Jiaqi Liu, Lele Wu, Haoliang Hu, Lu He, Shifang Huang, Zhe Chen, Lanfang Li, Linxi Chen
Apelin is the endogenous ligand of APJ receptor. Both monocytes (MCs) and human umbilical vein endothelial cells (HUVECs) express apelin and APJ, which play important roles in the physiological processes of atherosclerosis. Our previous research indicated that apelin-13 promoted MCs-HUVECs adhesion. Here, we further explore the mechanism responsible for MCs-HUVECs adhesion induced by apelin-13. Apelin-13 promoted reactive oxygen species (ROS) generation and NOX4 expression in HUVECs. Apelin-13 inducedautophagy, increased proteins beclin1 and LC3-II/I expression and induced autophagy flux in HUVECs, which was blocked by NAC, catalase and DPI...
April 24, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29676411/functional-integration-and-self-template-synthesis-of-hollow-core-shell-carbon-mesoporous-spheres-fe-3-o-4-nitrogen-doped-graphene-to-enhance-catalytic-activity-in-dsscs
#16
Jixin Yao, Kang Zhang, Wen Wang, Xueqin Zuo, Qun Yang, Huaibao Tang, Mingzai Wu, Guang Li
Excellent corrosion resistance is crucial for photovoltaic devices to acquire high and stable performance under high corrosive complicated environments. Creative inspiration comes from sandwich construction, whereby Fe3O4 nanoparticles were anchored onto hollow core-shell carbon mesoporous microspheres and wrapped by N-graphene nanosheets (HCCMS/Fe3O4@N-RGO) to obtain integrated high corrosive resistance and stability. The as-prepared multiple composite material possesses outstanding performance as a result of structure optimization, performance improvement, and interface synergy...
April 20, 2018: Nanoscale
https://www.readbyqxmd.com/read/29666509/the-spatial-variation-in-the-effects-of-air-pollution-on-cardiovascular-mortality-in-beijing-china
#17
Wenjing Li, Yang Cao, Runkui Li, Xinming Ma, Jieying Chen, Zhenglai Wu, Qun Xu
Owing to lack of data from multiple air quality monitoring stations, studies about spatial association between concentrations of ambient pollutants and mortality in China are rare. To investigate the spatial variation of association between concentrations of particulate matter less than 10 μm in aerodynamic diameter (PM10 ), nitrogen dioxide (NO2 ) and carbon monoxide (CO) and cardiovascular mortality in Beijing, China, we collected data including daily deaths, concentrations of PM10 , NO2 and CO, and meteorological factors from 1 January 2009 to 31 December 2010 in all 16 districts of Beijing...
May 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29665366/3-7-bis-2-hydroxyethyl-icaritin-a-potent-inhibitor-of-phosphodiesterase-5-prevents-monocrotaline-induced-pulmonary-arterial-hypertension-via-no-cgmp-activation-in-rats
#18
Tao-Hua Lan, Xiao-Ling Chen, Yun-Shan Wu, Hui-Liang Qiu, Jun-Zhe Li, Xin-Min Ruan, Dan-Ping Xu, Dong-Qun Lin
Pulmonary arterial hypertension (PAH) is a chronic progressive disease which leads to elevated pulmonary arterial pressure and right heart failure. 3,7-Bis(2-hydroxyethyl)icaritin (ICT), an icariin derivatives, was reported to have potent inhibitory activity on phosphodiesterase type 5 (PDE5) which plays a crucial role in the pathogenesis of PAH. The present study was designed to investigate the effects of ICT on monocrotaline (MCT)-induced PAH rat model and reveal the underlying mechanism. MCT-induced PAH rat models were established with intragastric administration of ICT (10, 20, 40mg/kg/d), Icariin (ICA) (40mg/kg/d) and Sildenafil (25mg/kg/d)...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29663360/microrna-30d-preserves-pancreatic-islet-%C3%AE-cell-function-through-negative-regulation-of-the-jnk-signaling-pathway-via-socs3-in-mice-with-streptozotocin-induced-diabetes-mellitus
#19
Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Wei Xu, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
The loss of pancreatic islet β-cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet β-cell apoptosis. Hence, during the present study a streptozotocin-induced DM mice model was established in a bid to ascertain as to whether microRNA-30d (miR-30d) plays a regulatory role in the JNK pathway in relation to islet β-cell dysfunction. The collection and identification of the islet β cells from streptozotocin-induced mice was performed...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663098/alterations-in-normal-aging-revealed-by-cortical-brain-network-constructed-using-ibaspm
#20
Wan Li, Chunlan Yang, Feng Shi, Qun Wang, Shuicai Wu, Wangsheng Lu, Shaowu Li, Yingnan Nie, Xin Zhang
Normal aging has been linked with the decline of cognitive functions, such as memory and executive skills. One of the prominent approaches to investigate the age-related alterations in the brain is by examining the cortical brain connectome. IBASPM is a toolkit to realize individual atlas-based volume measurement. Hence, this study seeks to determine what further alterations can be revealed by cortical brain networks formed by IBASPM-extracted regional gray matter volumes. We found the reduced strength of connections between the superior temporal pole and middle temporal pole in the right hemisphere, global hubs as the left fusiform gyrus and right Rolandic operculum in the young and aging groups, respectively, and significantly reduced inter-module connection of one module in the aging group...
April 16, 2018: Brain Topography
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