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https://www.readbyqxmd.com/read/28703873/cryoballoon-ablation-in-chinese-patients-with-paroxysmal-atrial-fibrillation-1-year-follow-up
#1
Tian-You Ling, Qi Jin, Wen-Qi Pan, Ning Zhang, Chang-Jian Lin, Hon-Chi Lee, Li-Qun Wu
OBJECTIVES: We assessed the effectiveness and safety of cryoballoon ablation (CBA) in the Chinese population with paroxysmal atrial fibrillation (AF) with a 1-year follow-up and determined the association of early recurrence of atrial tachyarrhythmias (ERAT) with late recurrence (LR). METHODS: A total of 114 patients (age 61±10 years, 78 males) with paroxysmal AF who underwent CBA were consecutively enrolled. After procedures, patients were observed for 3 d with continuous ECG monitoring in the hospital with routine follow-up visits at 3-month, 6-month, and 1-year...
July 13, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28702587/simple-fluorescence-sensing-of-extreme-acidity-based-on-inner-filter-effect-of-ascorbic-acid-to-fluorescent-au-nanoclusters
#2
Ronghui Zhou, Yuqin Li, Yuanyuan Tian, Qun Sun, Pengchi Deng, Lan Wu, Xiandeng Hou
As acidic pH plays essential roles in several organelles, development of pH sensors for extreme acidity is of vital importance. Herein, on the basis of the inner filter effect (IFE) between ascorbic acid (AA) and Au nano-clusters (AuNCs), a simple extreme acidity fluorescence sensor was developed without complex organic synthesis. The as-prepared probe can be used to detect acidity within the pH range of 2.4-4.6. Moreover, the probe possesses high selectivity, good photostability, and excellent reversibility for monitoring extreme acidity in bacterial cells without the influence of autofluorescence...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28700331/demethylation-of-the-mir145-promoter-suppresses-migration-and-invasion-in-breast-cancer
#3
Shui-Yi Liu, Xiao-Yi Li, Wei-Qun Chen, Hui Hu, Bo Luo, Yu-Xiang Shi, Tang-Wei Wu, Yong Li, Qing-Zhi Kong, Hong-Da Lu, Zhong-Xin Lu
miR-145 has been implicated in the progression of breast cancer. Here, we report that its expression is decreased in breast cancer specimens and cell lines and that this low level of expression is associated with DNA methylation of its gene, MIR145. Methylation of MIR145 has previously been correlated with cell migration and invasion, both in vivo and in vitro. We found that demethylation of MIR145 reactivates miR-145 and contributes to the anti-cancer properties of 5-aza-2'-deoxyazacytidine (5-AzaC). Therefore, miR-145 is a potentially valuable biomarker for breast cancer...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700232/revealing-the-role-of-interfacial-properties-on-catalytic-behaviors-by-in-situ-surface-enhanced-raman-spectroscopy
#4
Hua Zhang, Xia-Guang Zhang, Jie Wei, Chen Wang, Shu Chen, Han-Lei Sun, Ya-Hao Wang, Bing-Hui Chen, Zhi-Lin Yang, De-Yin Wu, Jian-Feng Li, Zhong-Qun Tian
Insightful understanding of how interfacial structures and properties affect catalytic processes is one of the most challenging issues in heterogeneous catalysis. Here, the essential roles of Pt-Au and Pt-oxide-Au interfaces on the activation of H2 and the hydrogenation of para-nitrothiophenol (pNTP) were studied at molecular level by in-situ surface-enhanced Raman spectroscopy (SERS) and shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS). Pt-Au and Pt-oxide-Au interfaces were fabricated through the synthesis of Pt-on-Au and Pt-on-SHINs nanocomposites...
July 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28684654/adipocyte-derived-exosomes-promote-lung-cancer-metastasis-by-increasing-mmp9-activity-via-transferring-mmp3-to-lung-cancer-cells
#5
REVIEW
Jia-Zhou Ye, Yan-Yan Wang, Tao Bai, Jie Chen, Bang-De Xiang, Fei-Xiang Wu, Le-Qun Li
Portal vein tumor thrombus (PVTT) usually worsens prognosis of hepatocellular carcinoma (HCC), as characterized by aggressive disease progression, impaired liver function and tolerance to treatment. Conventionally, the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) accepted the Barcelona Clinical Liver Cancer (BCLC) treatment algorithms, identifying PVTT as an absolute contra-indication of surgical resection for HCC. HCC-PVTT patients are offered sorafenib as the standard treatment...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28684653/surgical-resection-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-in-the-asia-pacific-region-beyond-the-barcelona-clinical-liver-cancer-treatment-algorithms-a-review-and-update
#6
Jia-Zhou Ye, Yan-Yan Wang, Tao Bai, Jie Chen, Bang-De Xiang, Fei-Xiang Wu, Le-Qun Li
Portal vein tumor thrombus (PVTT) usually worsens prognosis of hepatocellular carcinoma (HCC), as characterized by aggressive disease progression, impaired liver function and tolerance to treatment. Conventionally, the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) accepted the Barcelona Clinical Liver Cancer (BCLC) treatment algorithms, identifying PVTT as an absolute contra-indication of surgical resection for HCC. HCC-PVTT patients are offered sorafenib as the standard treatment...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28679864/celastrol-ameliorates-inflammation-through-inhibition-of-nlrp3-inflammasome-activation
#7
Xianjun Yu, Qun Zhao, Xixi Zhang, Haiwei Zhang, Yongbo Liu, Xiaoxia Wu, Ming Li, Xiaoming Li, Jingxuan Zhang, Xuzhi Ruan, Haibing Zhang
Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1β secretion both in vitro and in vivo. Notably, interruption of ASC oligomerization and autophagy activation are involved in NLRP3 inflammasome inactivation by celastrol...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28677735/mir%C3%A2-199a%C3%A2-3p-is-involved-in-the-pathogenesis-and-progression-of-diabetic-neuropathy-through-downregulation-of-serpine2
#8
Ying-Bo Li, Qun Wu, Jie Liu, Yong-Zhi Fan, Kai-Feng Yu, Yi Cai
The present study aimed to investigate the expression status of miRNA‑199a‑3p in patients with diabetic neuropathy (DN) and the mechanism by which this miRNA is involved in the genesis of DN. The expression of miRNA‑199a‑3p in plasma of peripheral blood was compared between patients with diabetes and a family history of diabetes and control volunteers by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR); in 60 diabetes patients, 45 (75%) demosntrated upregulated miR‑199a‑3p expression compared with control volunteer plasma...
June 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28671823/field-induced-slow-magnetic-relaxation-in-an-octacoordinated-fe-ii-complex-with-pseudo-d2d-symmetry-magnetic-hf-epr-and-theoretical-investigations
#9
Guo-Ling Li, Shu-Qi Wu, Li-Fang Zhang, Zhenxing Wang, Zhong-Wen Ouyang, Zhong-Hai Ni, Sheng-Qun Su, Zi-Shuo Yao, Jun-Qiu Li, Osamu Sato
An octacoordinated Fe(II) complex, [Fe(II)(dpphen)2](BF4)2·1.3H2O (1; dpphen = 2,9-bis(pyrazol-1-yl)-1,10-phenanthroline), with a pseudo-D2d-symmetric metal center has been synthesized. Magnetic, high-frequency/-field electron paramagnetic resonance (HF-EPR), and theoretical investigations reveal that 1 is characterized by uniaxial magnetic anisotropy with a negative axial zero-field splitting (ZFS) (D ≈ -6.0 cm(-1)) and a very small rhombic ZFS (E ≈ 0.04 cm(-1)). Under applied dc magnetic fields, complex 1 exhibits slow magnetic relaxation at low temperature...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28658680/submucosal-fibrosis-in-achalasia-patients-is-a-rare-cause-of-aborted-peroral-endoscopic-myotomy-procedures
#10
Qiu-Ning Wu, Xiao-Yue Xu, Xiao-Cen Zhang, Mei-Dong Xu, Yi-Qun Zhang, Wei-Feng Chen, Ming-Yan Cai, Wen-Zheng Qin, Jian-Wei Hu, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou
Background and aims Peroral endoscopic myotomy (POEM) is now an established treatment for esophageal achalasia. The standard protocol ensures a smooth operation in most patients, but technical challenges and failures exist and little is known about the incidence, causes, and impact of aborted procedures. Here, using a large patient cohort, we attempted to answer these questions. Methods All patients admitted for planned POEM between August 2010 and July 2015 underwent chart review. Aborted POEM was defined as the inability to finish the procedure after submucosal injection...
June 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28648649/selective-inhibition-of-amygdala-neuronal-ensembles-encoding-nicotine-associated-memories-inhibits-nicotine-preference-and-relapse
#11
Yan-Xue Xue, Ya-Yun Chen, Li-Bo Zhang, Li-Qun Zhang, Geng-Di Huang, Shi-Chao Sun, Jia-Hui Deng, Yi-Xiao Luo, Yan-Ping Bao, Ping Wu, Ying Han, Bruce T Hope, Yavin Shaham, Jie Shi, Lin Lu
BACKGROUND: Nicotine craving and relapse often occurs after reactivation of nicotine reward memories. We recently developed a memory retrieval-reconsolidation interference procedure in which reactivating nicotine reward memories by acute exposure to nicotine (the unconditioned stimulus [UCS]) and then pharmacologically interfering with memory reconsolidation decreased relapse to nicotine seeking in rats and nicotine craving in smokers. Here, we investigated underlying mechanisms. METHODS: In the first series of experiments, we trained rats for nicotine-induced conditioned place preference (CPP) or nicotine self-administration and ventricularly microinjected them with the protein synthesis inhibitor anisomycin immediately after UCS-induced memory retrieval...
May 11, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28641616/-effect-of-lpxn-overexpression-on-the-proliferation-adhesion-and-invasion-of-thp-1-cells-and-its-mechamisms
#12
Hai-Ping Dai, Guo-Hua Zhu, Li-Li Wu, Qian Wang, Hong Yao, Qin-Rong Wang, Li-Jun Wen, Hui-Ying Qiu, Qun Shen, Su-Ning Chen, De-Pei Wu
OBJECTIVE: To explore the effect of LPXN overexpression on the proliferation, adhesion and invasion of THP-1 cells and its possible mechanism. METHODS: A THP-1 cell line with stable overexpression of LPXN was constucted by using a lentivirus method, CCK-8 was used to detect the proliferation of cells, adhesion test was used to evaluate adhesion ablity of cells to Fn. Transwell assay was used to detect the change of invasion capability. Western blot was used to detect expression of LPXN, ERK, pERK and integrin α4, α5, β1, the Gelatin zymography was applied to detect activity of MMP2/MMP9 secreted by the THP-1 cells...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28634385/vertical-and-bevel-structured-sic-etching-techniques-incorporating-different-gas-mixture-plasmas-for-various-microelectronic-applications
#13
Ho-Kun Sung, Tian Qiang, Zhao Yao, Yang Li, Qun Wu, Hee-Kwan Lee, Bum-Doo Park, Woong-Sun Lim, Kyung-Ho Park, Cong Wang
This study presents a detailed fabrication method, together with validation, discussion, and analysis, for state-of-the-art silicon carbide (SiC) etching of vertical and bevelled structures by using inductively coupled plasma reactive ion etching (ICP-RIE) for microelectronic applications. Applying different gas mixtures, a maximum bevel angle of 87° (almost vertical), large-angle bevels ranging from 40° to 80°, and small-angel bevels ranging from 7° to 17° were achieved separately using distinct gas mixtures at different ratios...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620141/impact-of-persistence-on-survival-of-patients-with-breast-cancer-treated-with-endocrine-therapy-in-northeast-china-a-prospective-study
#14
Peng Xing, Huiting Dong, Qun Liu, Fan Yao, Yingying Xu, Bo Chen, Xinyu Zheng, Yunfei Wu, Feng Jin, Jiguang Li
The purpose of this prospective study is to investigate the impact of endocrine treatment persistence on the survival of patients with estrogen receptor-positive breast cancer treated with endocrine therapy and identify the risk factors influencing the treatment persistence. We enrolled 1085 patients from Northeast China who were diagnosed as stage I-III, estrogen receptor-positive breast cancer between January 2007 and December 2010. The prognostic factors for disease-free survival (DFS) and overall survival (OS) of patients were identified using univariate and multivariate Cox proportional hazards regression models...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28612528/-effects-of-gubentongluo-formula-on-oxidative-stress-reflected-by-expressions-of-ppar%C3%AE-and-l-fabp-in-mice-with-iga-nephropathy
#15
Wen-Wen Li, Di Huang, Pei-Cheng Shen, Qing Wu, Chuan Sun, Xian-Xian Wang, Li-Qun He
OBJECTIVES: To determine the underlying mechanism of Gubentongluo Formula in the treatment of IgA nephropathy (IgAN). METHODS: C57BL/6 mice were randomly divided into four groups: normal group (n =10), IgAN group (n =10), control group (n =10) and treatment group (n =10). Mice in the normal and IgAN groups were intragastricly administered with normal saline for 12 weeks; while those in the control and treatment groups were given fenofibrate [30 mg/(kg!$d) and Gubentongluo Formula [1...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28605773/biom2metdisease-a-manually-curated-database-for-associations-between-micrornas-metabolites-small-molecules-and-metabolic-diseases
#16
Yanjun Xu, Haixiu Yang, Tan Wu, Qun Dong, Zeguo Sun, Desi Shang, Feng Li, Yingqi Xu, Fei Su, Siyao Liu, Yunpeng Zhang, Xia Li
http://www.bio-bigdata.com/BioM2MetDisease/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28599320/keratin-8-reduces-colonic-permeability-and-maintains-gut-microbiota-homeostasis-protecting-against-colitis-and-colitis-associated-tumorigenesis
#17
Chao Liu, En-Dong Liu, Yun-Xiao Meng, Xiao-Ming Dong, Ya-Lan Bi, Huan-Wen Wu, Yan-Chao Jin, Ke Zhao, Jian-Jie Li, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Xiao-Ming Yang, Chang-Yan Li
Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the colon during DSS-induced colitis and AOM/DSS-induced colitis-associated colorectal cancer (CAC) development. In human patients with colon cancer, CK8 is downregulated. Using CK8 heterozygous knockout mice (CK8+/-), we found that CK8+/- mice are highly susceptible to DSS-induced colitis and more prone to AOM/DSS-induced CAC than wild type (WT) mice...
May 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28580900/preliminary-epidemiology-of-human-infections-with-highly-pathogenic-avian-influenza-a-h7n9-virus-china-2017
#18
Lei Zhou, Yi Tan, Min Kang, Fuqiang Liu, Ruiqi Ren, Yali Wang, Tao Chen, Yiping Yang, Chao Li, Jie Wu, Hengjiao Zhang, Dan Li, Carolyn M Greene, Suizan Zhou, A Danielle Iuliano, Fiona Havers, Daxin Ni, Dayan Wang, Zijian Feng, Timothy M Uyeki, Qun Li
We compared the characteristics of cases of highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) A(H7N9) virus infections in China. HPAI A(H7N9) case-patients were more likely to have had exposure to sick and dead poultry in rural areas and were hospitalized earlier than were LPAI A(H7N9) case-patients.
August 17, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28574501/rip1-kinase-activity-dependent-roles-in-embryonic-development-of-fadd-deficient-mice
#19
Yongbo Liu, Cunxian Fan, Yifan Zhang, Xianjun Yu, Xiaoxia Wu, Xixi Zhang, Qun Zhao, Haiwei Zhang, Qun Xie, Ming Li, Xiaoming Li, Qiurong Ding, Hao Ying, Dali Li, Haibing Zhang
RIP1 is an essential regulator of TNF-induced signaling complexes mediating NF-κB activation, apoptosis and necroptosis. Loss of Rip1 rescues the embryonic lethality of Fadd or Caspase-8-deficient mice, even though the double knockout mice die shortly after birth like Rip1-deficient mice. Recent studies demonstrated that mice expressing RIP1 kinase-dead mutants developed normally and resisted necroptotic stimuli in vitro and in vivo. However, the impact of RIP1 kinase activity on Fadd(-/-) embryonic development remains unknown...
August 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28574291/temperature-sensitive-heparin-modified-poloxamer-hydrogel-with-affinity-to-kgf-facilitate-the-morphologic-and-functional-recovery-of-the-injured-rat-uterus
#20
He-Lin Xu, Jie Xu, Si-Si Zhang, Qun-Yan Zhu, Bing-Hui Jin, De-Li ZhuGe, Bi-Xin Shen, Xue-Qing Wu, Jian Xiao, Ying-Zheng Zhao
Endometrial injury usually results in intrauterine adhesion (IUA), which is an important cause of infertility and recurrent miscarriage in reproductive women. There is still lack of an effective therapeutic strategy to prevent occurrence of IUA. Keratinocyte growth factor (KGF) is a potent repair factor for epithelial tissues. Here, a temperature-sensitive heparin-modified poloxamer (HP) hydrogel with affinity to KGF (KGF-HP) was used as a support matrix to prevent IUA and deliver KGF. The rheology of KGF-HP hydrogel was carefully characterized...
November 2017: Drug Delivery
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