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https://www.readbyqxmd.com/read/28219438/genomic-insights-into-divergence-and-dual-domestication-of-cultivated-allotetraploid-cottons
#1
Lei Fang, Hao Gong, Yan Hu, Chunxiao Liu, Baoliang Zhou, Tao Huang, Yangkun Wang, Shuqi Chen, David D Fang, Xiongming Du, Hong Chen, Jiedan Chen, Sen Wang, Qiong Wang, Qun Wan, Bingliang Liu, Mengqiao Pan, Lijing Chang, Huaitong Wu, Gaofu Mei, Dan Xiang, Xinghe Li, Caiping Cai, Xiefei Zhu, Z Jeffrey Chen, Bin Han, Xiaoya Chen, Wangzhen Guo, Tianzhen Zhang, Xuehui Huang
BACKGROUND: Cotton has been cultivated and used to make fabrics for at least 7000 years. Two allotetraploid species of great commercial importance, Gossypium hirsutum and Gossypium barbadense, were domesticated after polyploidization and are cultivated worldwide. Although the overall genetic diversity between these two cultivated species has been studied with limited accessions, their population structure and genetic variations remain largely unknown. RESULTS: We resequence the genomes of 147 cotton accessions, including diverse wild relatives, landraces, and modern cultivars, and construct a comprehensive variation map to provide genomic insights into the divergence and dual domestication of these two important cultivated tetraploid cotton species...
February 20, 2017: Genome Biology
https://www.readbyqxmd.com/read/28216906/quality-by-design-multivariate-model-for-multicomponent-quantification-in-refining-process-of-honey
#2
Xiaoying Li, Zhisheng Wu, Xin Feng, Shanshan Liu, Xiaojie Yu, Qun Ma, Yanjiang Qiao
OBJECTIVE: A method for rapid analysis of the refining process of honey was developed based on near-infrared (NIR) spectroscopy. METHODS: Partial least square calibration models were built for the four components after the selection of the optimal spectral pretreatment method and latent factors. RESULTS: The models covered the samples of different temperatures and time points, therefore the models were robust and universal. CONCLUSIONS: These results highlighted that the NIR technology could extract the information of critical process and provide essential process knowledge of the honey refining process...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216227/nek7-protects-telomeres-from-oxidative-dna-damage-by-phosphorylation-and-stabilization-of-trf1
#3
Rong Tan, Satoshi Nakajima, Qun Wang, Hongxiang Sun, Jing Xue, Jian Wu, Sabine Hellwig, Xuemei Zeng, Nathan A Yates, Thomas E Smithgall, Ming Lei, Yu Jiang, Arthur S Levine, Bing Su, Li Lan
Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrity. Nek7 is recruited to telomeres and stabilizes TRF1 at telomeres after damage in an ATM activation-dependent manner. Nek7 deficiency leads to telomere aberrations, long-lasting γH2AX and 53BP1 foci, and augmented cell death upon oxidative telomeric DNA damage...
February 8, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28214653/neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-locoregionally-advanced-nasopharyngeal-carcinoma-a-phase-iii-multicentre-randomised-controlled-trial
#4
Su-Mei Cao, Qi Yang, Ling Guo, Hai-Qiang Mai, Hao-Yuan Mo, Ka-Jia Cao, Chao-Nan Qian, Chong Zhao, Yan-Qun Xiang, Xiu-Ping Zhang, Zhi-Xiong Lin, Wei-Xiong Li, Qing Liu, Fang Qiu, Rui Sun, Qiu-Yan Chen, Pei-Yu Huang, Dong-Hua Luo, Yi-Jun Hua, Yi-Shan Wu, Xing Lv, Lin Wang, Wei-Xiong Xia, Lin-Quan Tang, Yan-Fang Ye, Ming-Yuan Chen, Xiang Guo, Ming-Huang Hong
BACKGROUND: The role of neoadjuvant chemotherapy (NACT) for locoregionally advanced nasopharyngeal carcinoma (NPC) is unclear. We aimed to evaluate the feasibility and efficacy of NACT followed by concurrent chemoradiotherapy (CCRT) versus CCRT alone in locoregionally advanced NPC. METHODS: Patients with stage III-IVB (excluding T3N0-1) NPC were randomly assigned to receive NACT followed by CCRT (investigational arm) or CCRT alone (control arm). Both arms were treated with 80 mg/m(2) cisplatin every 3 weeks concurrently with radiotherapy...
February 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28212291/tracking-the-turn-maneuvering-target-using-the-multi-target-bayes-filter-with-an-adaptive-estimation-of-turn-rate
#5
Zong-Xiang Liu, De-Hui Wu, Wei-Xin Xie, Liang-Qun Li
Tracking the target that maneuvers at a variable turn rate is a challenging problem. The traditional solution for this problem is the use of the switching multiple models technique, which includes several dynamic models with different turn rates for matching the motion mode of the target at each point in time. However, the actual motion mode of a target at any time may be different from all of the dynamic models, because these models are usually limited. To address this problem, we establish a formula for estimating the turn rate of a maneuvering target...
February 15, 2017: Sensors
https://www.readbyqxmd.com/read/28185453/modification-of-the-highly-conductive-pedot-pss-layer-for-use-in-silver-nanogrid-electrodes-for-flexible-inverted-polymer-solar-cells
#6
Jie Wang, Fei Fei, Qun Luo, Shuhong Nie, Na Wu, Xiaolian Chen, Wenming Su, Yuanjie Li, Chang-Qi Ma
Silver nanogrid based flexible transparent electrode is recognized as the most promising alternative to ITO electrode for organic electronics, owing to its low production cost and excellent flexibility. Typically, a highly conductive thin film coating layer, such as highly conductive PEDOT:PSS (HC-PEDOT:PSS) is usually deposited onto the Ag-grid electrode to smooth the surface and to minimize the sheet resistance. In this paper, we found that inverted flexible polymer solar cells with structure of Ag-grid/HC-PEDOT:PSS/ZnO/photoactive layer/MoO3/Al generally exhibits strong S-shaped J-V curves, which could be eliminated by light-soaking treatment...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28154986/biodegradation-of-5-chloro-2-picolinic-acid-by-novel-identified-co-metabolizing-degrader-achromobacter-sp-f1
#7
Zhi-Guo Wu, Fang Wang, Li-Qun Ning, Robert D Stedtfeld, Zong-Zheng Yang, Jing-Guo Cao, Hong-Jie Sheng, Xin Jiang
Several bacteria have been isolated to degrade 4-chloronitrobenzene. Degradation of 4-chloronitrobenzene by Cupriavidus sp. D4 produces 5-chloro-2-picolinic acid as a dead-end by-product, a potential pollutant. To date, no bacterium that degrades 5-chloro-2-picolinic acid has been reported. Strain f1, isolated from a soil polluted by 4-chloronitrobenzene, was able to co-metabolize 5-chloro-2-picolinic acid in the presence of ethanol or other appropriate carbon sources. The strain was identified as Achromobacter sp...
February 2, 2017: Biodegradation
https://www.readbyqxmd.com/read/28154776/portal-vein-tumor-thrombus-is-a-bottleneck-in-the-treatment-of-hepatocellular-carcinoma
#8
Ju-Xian Sun, Jie Shi, Nan Li, Wei-Xing Guo, Meng-Chao Wu, Wan-Yee Lau, Shu-Qun Cheng
The effect of portal vein tumor thrombus (PVTT) on the prognosis of patients with hepatocellular carcinoma has become clear over the past several decades. However, identifying the mechanisms and performing the diagnosis and treatment of PVTT remain challenging. Therefore, this study aimed to summarize the progress in these areas. A computerized literature search in Medline and EMBASE was performed with the following combinations of search terms: "hepatocellular carcinoma" AND "portal vein tumor thrombus." Although several signal transduction or molecular pathways related to PVTT have been identified, the exact mechanisms of PVTT are still largely unknown...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28154240/epigenetic-regulation-of-antagonistic-receptors-confers-rice-blast-resistance-with-yield-balance
#9
Yiwen Deng, Keran Zhai, Zhen Xie, Dongyong Yang, Xudong Zhu, Junzhong Liu, Xin Wang, Peng Qin, Yuanzhu Yang, Guomin Zhang, Qun Li, Jianfu Zhang, Shuangqing Wu, Joëlle Milazzo, Bizeng Mao, Ertao Wang, Huaan Xie, Didier Tharreau, Zuhua He
Crop breeding aims to balance disease resistance with yield, however single resistance (R) genes can lead to resistance breakdown and R gene pyramiding may impact growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. In the cluster, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance...
February 2, 2017: Science
https://www.readbyqxmd.com/read/28152521/lncsubpathway-a-novel-approach-for-identifying-dysfunctional-subpathways-associated-with-risk-lncrnas-by-integrating-lncrna-and-mrna-expression-profiles-and-pathway-topologies
#10
Yanjun Xu, Feng Li, Tan Wu, Yingqi Xu, Haixiu Yang, Qun Dong, Meiyu Zheng, Desi Shang, Chunlong Zhang, Yunpeng Zhang, Xia Li
Long non-coding RNAs (lncRNAs) play important roles in various biological processes, including the development of many diseases. Pathway analysis is a valuable aid for understanding the cellular functions of these transcripts. We have developed and characterized LncSubpathway, a novel method that integrates lncRNA and protein coding gene (PCG) expression with interactome data to identify disease risk subpathways that functionally associated with risk lncRNAs. LncSubpathway identifies the most relevance regions which are related with risk lncRNA set and implicated with study conditions through simultaneously considering the dysregulation extent of lncRNAs, PCGs and their correlations...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28149786/the-association-between-retinal-vasculature-changes-and-stroke-a-literature-review-and-meta-analysis
#11
Hui-Qun Wu, Huan Wu, Li-Li Shi, Li-Yuan Yu, Li-Yuan Wang, Ya-Lan Chen, Jin-Song Geng, Jian Shi, Kui Jiang, Jian-Cheng Dong
AIM: To determine the association between retinal vasculature changes and stroke. METHODS: MEDLINE and EMBASE were searched for relevant human studies to September 2015 that investigated the association between retinal vasculature changes and the prevalence or incidence of stroke; the studies were independently examined for their qualities. Data on clinical characteristics and calculated summary odds ratios (ORs) were extracted for associations between retinal microvascular abnormalities and stroke, including stroke subtypes where possible, and adjusted for key variables...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28119249/aptamer-molecularly-imprinted-sensor-base-on-electrogenerated-chemiluminescence-energy-transfer-for-detection-of-lincomycin
#12
Shuhuai Li, Chunhua Liu, Guihao Yin, Qun Zhang, Jinhui Luo, Nanchun Wu
In this study, a biosensor with a dual recognition system comprising a molecularly imprinted polymer (MIP) and aptamers selective for lincomycin was fabricated. The MIP was synthesized by electropolymerization of carbon dots (C-dots)-tagged DNA aptamers combined with lincomycin and o-aminophenol on the gold-nanoparticle-functionalized graphene oxide (Au-GO)-modified electrode. Electrogenerated chemiluminescence (ECL) resonance energy transfer was observed between Au-GO and C-dots. After the C-dots accepted the energy, they acted as a signal indicator and exhibited enhanced signal intensity in the presence of target lincomycin...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28105115/hepatic-resection-versus-transarterial-chemoembolization-for-patients-with-barcelona-clinic-liver-cancer-intermediate-stage-child-pugh-a-hepatocellular-carcinoma
#13
Yin-Nong Zhao, Yong-Quan Zhang, Jia-Zhou Ye, Xing Liu, Hong-Zhi Yang, Feng-Yun Cong, Bang-De Xiang, Fei-Xiang Wu, Liang Ma, Le-Qun Li, Hai-Hong Ye
The present study aimed to compare the overall and recurrence-free survival rates following hepatic resection (HR) and transcatheter arterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) classified intermediate-stage Child-Pugh A hepatocellular carcinoma (HCC). A total of 443 patients were examined, among whom 274 underwent HR, whereas 169 received TACE. The overall survival, recurrence-free survival between groups and subgroups, and risk factors with respect to mortality and recurrence, were analyzed...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28102199/comparison-of-efficacy-of-simo-decoction-and-acupuncture-or-chewing-gum-alone-on-postoperative-ileus-in-colorectal-cancer-resection-a-randomized-trial
#14
Yang Yang, Hong-Qun Zuo, Zhao Li, Yu-Zhou Qin, Xian-Wei Mo, Ming-Wei Huang, Hao Lai, Liu-Cheng Wu, Jian-Si Chen
To compared the ability of chewing gum or simo decoction (SMD) and acupuncture to reduce incidence of postoperative ileus (POI) after colorectal cancer resection, patients with colorectal cancer undergoing open or laparoscopic resection were randomized to receive SMD and acupuncture (n = 196), chewing gum alone (n = 197) or no intervention (n = 197) starting on postoperative day 1 and continuing for 5 consecutive days. Patients treated with SMD and acupuncture experienced significantly shorter hospital stay, shorter time to first flatus and shorter time to defecation than patients in the other groups (all P < 0...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098258/unidirectional-invisibility-induced-by-parity-time-symmetric-circuit
#15
Bo Lv, Jiahui Fu, Bian Wu, Rujiang Li, Qingsheng Zeng, Xinhua Yin, Qun Wu, Lei Gao, Wan Chen, Zhefei Wang, Zhiming Liang, Ao Li, Ruyu Ma
Parity-time (PT) symmetric structures present the unidirectional invisibility at the spontaneous PT-symmetry breaking point. In this paper, we propose a PT-symmetric circuit consisting of a resistor and a microwave tunnel diode (TD) which represent the attenuation and amplification, respectively. Based on the scattering matrix method, the circuit can exhibit an ideal unidirectional performance at the spontaneous PT-symmetry breaking point by tuning the transmission lines between the lumped elements. Additionally, the resistance of the reactance component can alter the bandwidth of the unidirectional invisibility flexibly...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067040/large-pore-3d-cubic-mesoporous-kit-6-hybrid-bearing-a-hard-soft-donor-combined-ligand-for-enhancing-u-vi-capture-an-experimental-and-theoretical-investigation
#16
Li-Yong Yuan, Lin Zhu, Cheng-Liang Xiao, Qun-Yan Wu, Nan Zhang, Ji-Pan Yu, Zhi-Fang Chai, Wei-Qun Shi
A preorganized tetradentate phenanthrolineamide (DAPhen) ligand with hard and soft donors combined in the same molecule has been found to possess high extraction ability toward actinides over lanthanides from acidic aqueous solution in our previous work. Herein we grafted phenanthrolineamide groups onto a large-pore three-dimensional cubic silica support by the reaction of DAPhen siloxane with KIT-6 substrate to prepare a novel uranium-selective sorbent, KIT-6-DAPhen. The as-synthesized sorbent was well-characterized by scanning electron microscopy, high-resolution transmission electron microscopy, N2 adsorption/desorption, X-ray diffraction, FT-IR, (13)C cross-polarization magic-angle spinning NMR, and TGA techniques, which confirmed the consummation of the functionalization...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056840/rapid-increase-of-scrub-typhus-incidence-in-guangzhou-southern-china-2006-2014
#17
Ye Sun, Yue-Hong Wei, Yang Yang, Yu Ma, Sake J de Vlas, Hong-Wu Yao, Yong Huang, Mai-Juan Ma, Kun Liu, Xiao-Ning Li, Xin-Lou Li, Wen-Hui Zhang, Li-Qun Fang, Zhi-Cong Yang, Wu-Chun Cao
BACKGROUND: In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS: Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of ST using a panel negative binomial model. RESULTS: A total of 4821 scrub typhus cases were reported in Guangzhou during 2006-2014...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056197/transarterial-embolization-with-or-without-chemotherapy-what-should-be-the-indication-for-patients-with-hepatocellular-carcinoma
#18
Jian-Hong Zhong, Jun-Tao Tan, Li-Qun Li, Wen-Shu Wu, Chang Zhao
No abstract text is available yet for this article.
January 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27988396/total-sesquiterpene-lactones-prepared-from-inula-helenium-l-has-potentials-in-prevention-and-therapy-of-rheumatoid-arthritis
#19
Shuang Gao, Qun Wang, Xin-Hui Tian, Hui-Liang Li, Yun-Heng Shen, Xi-Ke Xu, Guo-Zhen Wu, Zhen-Lin Hu, Wei-Dong Zhang
BACKGROUNDS: Inula helenium L. is an herb with anti-inflammatory properties. Sesquiterpene lactones (SLs), mainly alantolactone (AL) and isoalantolactone (IAL), are considered as its active ingredients. However, the anti-inflammatory effects of SL-containing extracts of I. helenium have not been explored. Here we prepared total SLs from I. helenium (TSL-IHL), analyzed its chemical constituents, and performed cellular and animal studies to evaluate its anti-inflammatory activities. MATERIALS AND METHODS: The chemical profile of TSL-IHL was analyzed by HPLC-UV...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27978435/an-e3%C3%A2-ubiquitin-ligase-bag-protein-module-controls-plant-innate-immunity-and-broad-spectrum-disease-resistance
#20
Quanyuan You, Keran Zhai, Donglei Yang, Weibing Yang, Jingni Wu, Junzhong Liu, Wenbo Pan, Jianjun Wang, Xudong Zhu, Yikun Jian, Jiyun Liu, Yingying Zhang, Yiwen Deng, Qun Li, Yonggen Lou, Qi Xie, Zuhua He
Programmed cell death (PCD) and immunity in plants are tightly controlled to promote antimicrobial defense while preventing autoimmunity. However, the mechanisms contributing to this immune homeostasis are poorly understood. Here, we isolated a rice mutant ebr1 (enhanced blight and blast resistance 1) that shows enhanced broad-spectrum bacterial and fungal disease resistance, but displays spontaneous PCD, autoimmunity, and stunted growth. EBR1 encodes an E3 ubiquitin ligase that interacts with OsBAG4, which belongs to the BAG (Bcl-2-associated athanogene) family that functions in cell death, growth arrest, and immune responses in mammals...
December 14, 2016: Cell Host & Microbe
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