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https://www.readbyqxmd.com/read/27923879/orosomucoid-proteins-interact-with-the-small-subunit-of-serine-palmitoyltransferase-and-contribute-to-sphingolipid-homeostasis-and-stress-responses-in-arabidopsis
#1
Jian Li, Jian Yin, Chan Rong, Kai-En Li, Jian-Xin Wu, Li-Qun Huang, Hong-Yun Zeng, Sunil Kumar Sahu, Nan Yao
Serine palmitoyltransferase (SPT), a pyridoxyl-5'-phosphate-dependent enzyme, catalyzes the first and rate-limiting step in sphingolipid biosynthesis. In humans and yeast, orosomucoid proteins (ORMs) negatively regulate SPT and thus play an important role in maintaining sphingolipid levels. Despite the importance of sphingoid intermediates as bioactive molecules, the regulation of sphingolipid biosynthesis through SPT is not well understood in plants. Here, we identified and characterized the Arabidopsis thaliana ORMs, ORM1 and ORM2...
December 6, 2016: Plant Cell
https://www.readbyqxmd.com/read/27921368/competing-mechanisms-in-the-acetaldehyde-functionalization-of-positively-charged-hydrogenated-silicene
#2
Li-Kun Yang, Xia-Guang Zhang, Fang-Zu Yang, De-Yin Wu, Zhong-Qun Tian, Xiang-Yang Liu
Density functional theory calculations have been used to elucidate the mechanism of the addition reaction of acetaldehyde to the positively charged hydrogenated silicene (H-silicene). We find that the positively charged H-silicene plane could be partially restructured to form a vacant Si site, enabling a further nucleophilic addition reaction. After acetaldehyde molecule attached to the H-silicene plane, two competing pathways are involved in hydrogen abstraction process: a random reaction mechanism and a chain reaction mechanism...
December 6, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27920236/the-efficacy-of-recombinant-fviii-low-dose-prophylaxis-in-chinese-pediatric-patients-with-severe-hemophilia-a-a-retrospective-analysis-from-the-recare-study
#3
Wanru Yao, Juan Xiao, Xiaoling Cheng, Guoshuang Feng, Changgang Li, Xinsheng Zhang, Qun Hu, Weiqun Xu, Jing Sun, Renchi Yang, Xiaojing Li, Rongfu Zhou, Shimei Lian, Jian Gu, Junde Wu, Yongqiang Zhao, Runhui Wu
OBJECTIVE: This study explores the efficacy of recombinant factor VIII (rFVIII) low-dose prophylaxis in Chinese pediatric patients with severe hemophilia A from the Retrospective Study in Chinese Pediatric Hemophilia A Patients With rFVIII Contained Regular Prophylaxis (ReCARE) population. METHODS: This is additional analysis of the multicenter, retrospective ReCARE study, in which the annual bleeding rate (ABR), annual joint bleeding rate (AJBR), and safety of >12-week, low dose (10-30 IU/kg/wk) rFVIII prophylaxis divided into primary, secondary, and tertiary groups based on the joint status and joint bleeding history were analyzed...
December 5, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27919852/prognosis-of-hepatocellular-carcinoma-with-bile-duct-tumor-thrombus-after-r0-resection-a-matched-study
#4
Ding-Ding Wang, Li-Qun Wu, Zu-Sen Wang
BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The present study aimed to determine post-surgical prognoses in HCC patients with BDTT, as outcomes are currently unclear. METHODS: We compared the prognoses of 110 HCC patients without BDTT (group A) to 22 cases with BDTT (group B). The two groups were matched in age, gender, tumor etiology, size, number, portal vascular invasion, and TNM stage. Additionally, 28 HCC patients with BDTT were analyzed to identify prognostic risk factors...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27916955/multi-residue-analysis-of-pesticide-residues-in-crude-pollens-by-uplc-ms-ms
#5
Zhou Tong, Yan-Can Wu, Qiong-Qiong Liu, Yan-Hong Shi, Li-Jun Zhou, Zhen-Yu Liu, Lin-Sheng Yu, Hai-Qun Cao
A multi-residue method for the determination of 54 pesticide residues in pollens has been developed and validated. The proposed method was applied to the analysis of 48 crude pollen samples collected from eight provinces of China. The recovery of analytes ranged from 60% to 136% with relative standard deviations (RSDs) below 30%. Of the 54 targeted compounds, 19 pesticides were detected. The major detection rates of each compound were 77.1% for carbendazim, 58.3% for fenpropathrin, 56.3% for chlorpyrifos, 50...
December 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27910959/acute-effects-of-nitrogen-dioxide-on-cardiovascular-mortality-in-beijing-an-exploration-of-spatial-heterogeneity-and-the-district-specific-predictors
#6
Kai Luo, Runkui Li, Wenjing Li, Zongshuang Wang, Xinming Ma, Ruiming Zhang, Xin Fang, Zhenglai Wu, Yang Cao, Qun Xu
The exploration of spatial variation and predictors of the effects of nitrogen dioxide (NO2) on fatal health outcomes is still sparse. In a multilevel case-crossover study in Beijing, China, we used mixed Cox proportional hazard model to examine the citywide effects and conditional logistic regression to evaluate the district-specific effects of NO2 on cardiovascular mortality. District-specific predictors that could be related to the spatial pattern of NO2 effects were examined by robust regression models...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904693/berberine-upregulates-mir-22-3p-to-suppress-hepatocellular-carcinoma-cell-proliferation-by-targeting-sp1
#7
Jie Chen, Fei-Xiang Wu, Hong-Lin Luo, Jun-Jie Liu, Tao Luo, Tao Bai, Le-Qun Li, Xiao-Hui Fan
MicroRNA-22-3p (miR-22-3p) is downregulated in hepatocellular carcinoma (HCC), which contributes to the development and progression of HCC. In this study, berberine treatment upregulated miR-22-3p expression in HepG2 cells. Therefore, we investigated whether berberine suppresses the proliferation of HCC cells and explored the underlying mechanism. The HCC HepG2 cell line was treated with a gradient of berberine concentrations (0-300 μM) for 48 h, and 100 μM berberine inhibited cell growth at 24 h. The HepG2 cells were then incubated with 100 μM berberine for 0-48 h, and after treatment for 24 h, berberine markedly suppressed HepG2 cell growth and significantly upregulated miR-22-3p expression...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27899915/novel-h7n2-and-h5n6-avian-influenza-a-viruses-in-sentinel-chickens-a-sentinel-chicken-surveillance-study
#8
Teng Zhao, Yan-Hua Qian, Shan-Hui Chen, Guo-Lin Wang, Meng-Na Wu, Yong Huang, Guang-Yuan Ma, Li-Qun Fang, Gregory C Gray, Bing Lu, Yi-Gang Tong, Mai-Juan Ma, Wu-Chun Cao
In 2014, a sentinel chicken surveillance for avian influenza viruses was conducted in aquatic bird habitat near Wuxi City, Jiangsu Province, China. Two H7N2, one H5N6, and two H9N2 viruses were isolated. Sequence analysis revealed that the H7N2 virus is a novel reassortant of H7N9 and H9N2 viruses and H5N6 virus is a reassortant of H5N1 clade 2.3.4 and H6N6 viruses. Substitutions V186 and L226 (H3 numbering) in the hemagglutinin (HA) gene protein was found in two H7N2 viruses but not in the H5N6 virus. Two A138 and A160 mutations were identified in the HA gene protein of all three viruses but a P128 mutation was only observed in the H5N6 virus...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27897265/mutations-in-acetylcholinesterase2-ace2-increase-the-insensitivity-of-acetylcholinesterase-to-fosthiazate-in-the-root-knot-nematode-meloidogyne-incognita
#9
Wen-Kun Huang, Qin-Song Wu, Huan Peng, Ling-An Kong, Shi-Ming Liu, Hua-Qun Yin, Ru-Qiang Cui, Li-Ping Zhan, Jiang-Kuan Cui, De-Liang Peng
The root-knot nematode Meloidogyne incognita causes severe damage to continuously cropping vegetables. The control of this nematode relies heavily on organophosphate nematicides in China. Here, we described resistance to the organophosphate nematicide fosthiazate in a greenhouse-collected resistant population (RP) and a laboratory susceptible population (SP) of M. incognita. Fosthiazate was 2.74-fold less toxic to nematodes from RP than that from SP. Quantitative real-time PCR revealed that the acetylcholinesterase2 (ace2) transcription level in the RP was significantly higher than that in the SP...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895748/serum-mir-300-as-a-diagnostic-and-prognostic-biomarker-in-osteosarcoma
#10
Jian-Dong Liu, Qun Xin, Chun-Sheng Tao, Pei-Feng Sun, Peng Xu, Bing Wu, Liang Qu, Shu-Zhong Li
In order to determine whether microRNA (miR)-300 is a diagnostic and prognostic biomarker in osteosarcoma, the miR-300 levels in serum of 114 osteosarcoma patients and 114 healthy controls were compared, followed by serum analysis of the differences between the pre-operative and post-operative sera of these osteosarcoma patients. It was observed that the concentration levels of miR-300 in the serum of osteosarcoma patients was significantly higher than those in the serum of healthy controls (P<0.01). Furthermore, the concentration levels of miR-300 in the post-operative serum were significantly reduced when compared with the pre-operative serum levels (P<0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895587/vitamin-d-signaling-through-induction-of-paneth-cell-defensins-maintains-gut-microbiota-and-improves-metabolic-disorders-and-hepatic-steatosis-in-animal-models
#11
Danmei Su, Yuanyang Nie, Airu Zhu, Zishuo Chen, Pengfei Wu, Li Zhang, Mei Luo, Qun Sun, Linbi Cai, Yuchen Lai, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Guihui Wu, Richard Hu, Hidekazu Tsukamoto, Aurelia Lugea, Zhenqui Liu, Stephen J Pandol, Yuan-Ping Han
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota, namely dysbiosis, is known to cause MetS and NAFLD. It is also known that systemic inflammation blocks insulin signaling pathways, leading to insulin resistance and glucose intolerance, which are the driving force for hepatic steatosis...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27857710/the-two-component-system-rsrs-rsrr-regulates-the-tetrathionate-intermediate-pathway-for-thiosulfate-oxidation-in-acidithiobacillus-caldus
#12
Zhao-Bao Wang, Ya-Qing Li, Jian-Qun Lin, Xin Pang, Xiang-Mei Liu, Bing-Qiang Liu, Rui Wang, Cheng-Jia Zhang, Yan Wu, Jian-Qiang Lin, Lin-Xu Chen
Acidithiobacillus caldus (A. caldus) is a common bioleaching bacterium that possesses a sophisticated and highly efficient inorganic sulfur compound metabolism network. Thiosulfate, a central intermediate in the sulfur metabolism network of A. caldus and other sulfur-oxidizing microorganisms, can be metabolized via the tetrathionate intermediate (S4I) pathway catalyzed by thiosulfate:quinol oxidoreductase (Tqo or DoxDA) and tetrathionate hydrolase (TetH). In A. caldus, there is an additional two-component system called RsrS-RsrR...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27843048/common-variants-predict-recurrence-after-nonfamilial-atrial-fibrillation-ablation-in-chinese-han-population
#13
Li-Qun Zhao, Guo-Bing Zhang, Zu-Jia Wen, Chun-Kai Huang, Hai-Qing Wu, Juan Xu, Bao-Zhen Qi, Zhi-Min Wang, Yong-Yong Shi, Shao-Wen Liu
BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between susceptibility loci and clinical recurrence of AF after catheter ablation have not been examined in Chinese Han populations. To the personalization of catheter ablation for AF, we examined whether these single nucleotide polymorphisms (SNPs) can predict clinical outcomes after catheter ablation for AF in Chinese Han population...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27829203/precision-combination-therapy-for-triple-negative-breast-cancer-via-biomimetic-polydopamine-polymer-core-shell-nanostructures
#14
Yanping Ding, Shishuai Su, Ruirui Zhang, Leihou Shao, Yinlong Zhang, Bin Wang, Yiye Li, Long Chen, Qun Yu, Yan Wu, Guangjun Nie
Photothermal-based combination therapy using functional nanomaterials shows great promise in eradication of aggressive tumors and improvement of drug sensitivity. The therapeutic efficacy and adverse effects of drug combinations depend on the precise control of timely tumor-localized drug release. Here a polymer-dopamine nanocomposite is designed for combination therapy, thermo-responsive drug release and prevention of uncontrolled drug leakage. The thermo-sensitive co-polymer poly (2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino) ethyl methacrylate-b-poly (D, l-lactide-co-glycolide) is constructed into core-shell structured nanoparticles for co-encapsulation of two cytotoxic drugs and absorption of small interfering RNAs against survivin...
November 2, 2016: Biomaterials
https://www.readbyqxmd.com/read/27814269/preprocedural-high-sensitivity-c-reactive-protein-predicts-contrast-induced-nephropathy-and-long-term-outcome-after-coronary-angiography
#15
Xiao-Sheng Guo, Kai-Yang Lin, Hua-Long Li, Ji-Yan Chen, Ying-Ling Zhou, Yong Liu, Ning Tan, Emily R Atkins, Peng Ran, Jun-Qing Yang, Deng-Xuan Wu, Shi-Qun Chen, Chong-Yang Duan, Ping-Yan Chen
We investigated whether high-sensitivity C-reactive protein (hsCRP) levels were associated with contrast-induced nephropathy (CIN) and long-term mortality after coronary angiography (CAG). Patients (N = 2133) undergoing CAG with preprocedural hsCRP were consecutively enrolled. High-sensitivity C-reactive protein was measured before angiography. Median follow-up was 2.3 years. The overall incidence of CIN was 2.77% (59 of 2133). There was a positive trend of hsCRP quartiles (Q) with rates of CIN: 0.9% for Q1 (<1...
October 25, 2016: Angiology
https://www.readbyqxmd.com/read/27813495/lentivirus-mediated-rnai-knockdown-of-insulin-like-growth-factor-1-receptor-inhibits-the-growth-and-invasion-of-hepatocellular-carcinoma-via-down-regulating-midkine-expression
#16
Cai Qun Bie, Xu You Liu, Ming Rong Cao, Qiu Yan Huang, Hui Jun Tang, Min Wang, Guo Li Cao, Ting Zhuang Yi, Sheng Lan Wu, Wei Jie Xu, Shao Hui Tang
The insulin-like growth factor-1 receptor (IGF-1R) overexpression contributes to the development of a variety of cancers. The present study explored the role of IGF-1R in the development and progression of hepatocellular carcinoma (HCC) and the possibility of IGF-1R silencing by lentivirus-mediated RNA interference (RNAi) as a therapeutic target for HCC. We showed that IGF-1R mRNA was up-regulated in Huh7 and Hep3B cells and human HCC tissues, and that IGF-1R knockdown by RNAi led to decreased proliferation, apoptosis induction, and decreased migration and invasion of Huh7 and Hep3B cells...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27806545/occupational-exposure-to-positive-blood-and-body-fluids-among-health-care-workers-in-a-chinese-university-hospital-a-three-years-retrospective-study
#17
Xiubin Tao, Hui Peng, Lihua Qian, Yan Li, Qun Wu, Jingjing Ruan, Dongzhen Cai
Health care workers (HCWs) are exposed to blood and body fluids (BBF) due to occupational accidents. However, few studies have investigated the prevalence of occupational exposure in Chinese HCWs thus far. There is a clearly a critical need to characterize its epidemiology more fully in China so that effective prevention programs can be implemented. We conducted a retrospective study at a university hospital in China, giving an epidemiological analysis on these exposed HCWs whose pathogens of BBF from patients were positive [human immunodeficiency virus (HIV) / hepatitis B (HBV) / hepatitis C (HCV)]...
August 11, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27768527/epidemiological-and-etiological-characteristics-of-herpangina-and-hand-foot-mouth-diseases-in-jiangsu-china-2013-2014
#18
Xin Yao, Lian-Lian Bian, Wei-Wei Lu, Jing-Xin Li, Qun-Ying Mao, Yi-Ping Wang, Fan Gao, Xing Wu, Qiang Ye, Xiu-Ling Li, Feng-Cai Zhu, Zhenglun Liang
Herpangina (HA) and hand, foot, and mouth disease (HFMD) are common infectious diseases caused by human enteroviruses and frequently occurr in young children. Previous published studies have mainly focused on HFMD, while the HA epidemiological and etiological characteristics in mainland China have not been described. From June, 2013 to March, 2014, HA and HFMD patients were monitored in participants from clinical trial of EV-A71 vaccine conducted during 2012-2013. A total of 95 HA patients and 161 HFMD patients were defined...
October 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27762061/sero-epidemiologic-study-of-influenza-a-h7n9-infection-among-exposed-populations-china-2013-2014
#19
Nijuan Xiang, Tian Bai, Kai Kang, Hui Yuan, Suizan Zhou, Ruiqi Ren, Xiuying Li, Jiabing Wu, Liquan Deng, Ge Zeng, Xianjun Wang, Shenghua Mao, Jian Shi, Rongbao Gao, Tao Chen, Sumei Zou, Dan Li, Fiona Havers, Marc-Alain Widdowson, Carolyn M Greene, Yanping Zhang, Daxin Ni, Xiaoqing Liu, Qun Li, Yuelong Shu
BACKGROUND: The first human infections of novel avian influenza A(H7N9) virus were identified in China in March 2013. Sentinel surveillance systems and contact tracing may not identify mild and asymptomatic human infections of influenza A(H7N9) virus. OBJECTIVES: We assessed the seroprevalence of antibodies to influenza A(H7N9) virus in three populations during the early stages of the epidemic. PATIENTS/METHODS: From March 2013-May 2014, we collected sera from the general population, poultry workers and contacts of confirmed infections in nine Chinese provinces reporting human A(H7N9) infections and, for contacts, second sera 2-3 weeks later...
October 20, 2016: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/27744377/comparative-population-genomics-reveals-genetic-basis-underlying-body-size-of-domestic-chickens
#20
Ming-Shan Wang, Yong-Xia Huo, Yan Li, Newton O Otecko, Ling-Yan Su, Hai-Bo Xu, Shi-Fang Wu, Min-Sheng Peng, He-Qun Liu, Lin Zeng, David M Irwin, Yong-Gang Yao, Dong-Dong Wu, Ya-Ping Zhang
Body size is the most important economic trait for animal production and breeding. Several hundreds of loci have been reported to be associated with growth trait and body weight in chickens. The loci are mapped to large genomic regions due to the low density and limited number of genetic markers in previous studies. Herein, we employed comparative population genomics to identify genetic basis underlying the small body size of Yuanbao chicken (a famous ornamental chicken) based on 89 whole genomes. The most significant signal was mapped to the BMP10 gene, whose expression was upregulated in the Yuanbao chicken...
October 15, 2016: Journal of Molecular Cell Biology
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