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https://www.readbyqxmd.com/read/29668071/human-papillomavirus-an-unlikely-etiologic-factor-in-sinonasal-inverted-papilloma
#1
Sepideh Mohajeri, Chi Lai, Bibianna Purgina, Dakheelallah Almutairi, Tabassom Baghai, Jim Dimitroulakos, Shaun Kilty
OBJECTIVES/HYPOTHESIS: Tenuous evidence has supported the hypothesis that sinonasal inverted papilloma (SNIP) arise from human papillomavirus (HPV) infection. To clarify the role of HPV in SNIP, all known HPV sub-types were evaluated by employing a robust polymerase chain reaction-based method in a wide variety of SNIPs from a single institution. STUDY DESIGN: Retrospective surgical specimen tumor sample analysis. METHODS: HPV positivity among SNIP samples and those with squamous cell carcinoma (SCC) were compared...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29665093/the-mapk-activator-protein-1-signaling-regulates-changes-in-lung-tissue-of-rat-exposed-to-hypobaric-hypoxia
#2
Mrinalini Singh, Seema Yadav, Meetul Kumar, Shweta Saxena, Deepika Saraswat, Anju Bansal, Shashi B Singh
This study reports the role of MAPKs (JNK, ERK, and p38), and activator protein-1 (AP-1) transcription factor in the hypobaric hypoxia induced change in lung tissue. Healthy male Sprague-Dawley rats were exposed to hypobaric hypoxia for 6, 12, 24, 48, 72, and 120 hr. Hypoxia resulted in significant increase in reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and decreased nitric oxide (NO), these act as signaling molecules for activation of MAPK and also contribute in development of vascular leakage (an indicator of pulmonary edema) as confirmed by histological studies...
April 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29664741/primary-vaginal-gastric-type-adenocarcinoma-and-vaginal-adenosis-exhibiting-gastric-differentiation-report-of-a-series-with-detailed-immunohistochemical-analysis
#3
Richard Wing-Cheuk Wong, Michelle Moore, Karen L Talia, Raji Ganesan, W Glenn McCluggage
So-called gastric-type adenocarcinoma and related premalignant lesions have been characterized in the cervix, but similar lesions are not widely recognized in the vagina. We report a series of 11 vaginal glandular lesions exhibiting gastric differentiation, comprising 5 cases of adenocarcinoma and 6 of adenosis. All cases occurred in adults (aged 33 to 69) with no known history of diethylstilboestrol exposure. The vaginal adenocarcinomas exhibited morphologic features identical to gastric-type adenocarcinoma of the cervix, but 1 case additionally demonstrated basaloid and sarcomatoid components, which have not been previously reported in cervical gastric-type adenocarcinoma...
April 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29662608/wt1-p53-and-p16-expression-in-the-diagnosis-of-low-and-high-grade-serous-ovarian-carcinomas-and-their-relation-to-prognosis
#4
Luis Felipe Sallum, Liliana Andrade, Susana Ramalho, Amanda Canato Ferracini, Rodrigo de Andrade Natal, Angelo Borsarelli Carvalho Brito, Luis Otávio Sarian, Sophie Derchain
Objective: To evaluate the diagnostic and prognostic value of the immunohistochemical expression of WT1, p53 and p16 in low- (LGSOCs) and high-grade serous ovarian carcinomas (HGSOCs). Results: HGSOC had a significantly higher proportion of advanced stage disease, higher CA125 levels, higher proportion of post-surgery residual disease and higher recurrence or disease progression. WT1 was expressed in 71.4% of LGSOCs and in 57.1% of HGSOCs ( p = 0.32). Focal and/or complete absence of p53 expression with negative p16 expression was found in 90...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29660830/cytologic-diagnosis-of-primary-peritoneal-high-grade-serous-carcinoma-in-a-man
#5
Brandon Umphress, John Philip, Yaxia Zhang, Xiaoqi Lin
Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm histologically indistinguishable from ovarian serous carcinoma primarily occurring in the female population. To date, extremely rare cases of PPSC have been reported in men; however, diagnosis by cytology has yet to be described. Here we present the clinical, radiographic, cytomorphologic, histologic and immunohistochemical (IHC) findings of a high-grade (HG) PPSC in a 70-year-old man with a history of prostatic adenocarcinoma. Core needle biopsy (CNB) touch preparation smears showed pleomorphic, round, columnar and polygonal epithelioid cells present singly or arranged in loosely cohesive three-dimensional clusters...
April 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29660164/high-grade-panin-presenting-with-localized-stricture-of-the-main-pancreatic-duct-a-clinicopathological-and-molecular-study-of-10-cases-suggests-a-clue-for-the-early-detection-of-pancreatic-cancer
#6
Masataka Yokode, Masayuki Akita, Kohei Fujikura, Mi-Ju Kim, Yukiko Morinaga, Seiichi Yoshikawa, Takuro Terada, Hiroshi Matsukiyo, Takuma Tajiri, Shiho Abe-Suzuki, Tomoo Itoh, Seung-Mo Hong, Yoh Zen
AIMS: This study aimed to identify the pathological features of high-grade PanIN that presents with imaging-detectable abnormalities. METHODS AND RESULTS: Ten cases of isolated, main-duct, high-grade PanIN as the primary clinical presentation were identified. All patients presented with stenosis of the main pancreatic duct, with 2 being associated with extensive upstream duct dilatation (>5 mm in diameter). Pancreatic juice cytology suggested adenocarcinoma in all 7 cases examined...
April 16, 2018: Histopathology
https://www.readbyqxmd.com/read/29656723/gastroenteritis-outbreak-at-a-health-function-caused-by-an-emerging-recombinant-strain-of-norovirus-gii-p16-gii-4-sydney-2012-australia
#7
B J Jones, J Flint, J Collins, P A White, J H Lun, D N Durrheim
An emerging recombinant norovirus GII.P16/GII.4 Sydney 2012 strain caused a gastroenteritis outbreak amongst attendees at a large health function in regional New South Wales, Australia. This was the third outbreak caused by the recombinant GII.P16/GII.4 Sydney 2012 strain in this region in 2017, which appears to be emerging as a common strain in the Hunter New England region.
April 16, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29652550/chia-seed-supplementation-reduces-senescence-markers-in-epididymal-adipose-tissue-of-high-fat-diet-fed-samp8-mice
#8
Yehua Rui, Shengyi Yang, Li-Hua Chen, Li-Qiang Qin, Zhongxiao Wan
Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-prone 8 (SAMP8) mice fed with high-fat diets (HFDs); and how chia seed can affect the above markers. SAMP8 mice and their control senescence-accelerated mouse-resistant 1 (SAMR1) were divided into four groups, that is, SAMR1 low-fat diet group (R1LF), SAMP8LF group (P8LF), SAMP8 high-fat group (P8HF), and SAMP8HF group supplemented with 10% chia seed (P8HC)...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29651745/correlations-between-age-functional-status-and-the-senescence-associated-proteins-hmgb2-and-p16-ink4a
#9
Ibiyonu Lawrence, Michael Bene, Timothy Nacarelli, Ashley Azar, Justin Z Cohen, Claudio Torres, Gregg Johannes, Christian Sell
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examined the correlation with age of two key proteins involved in the senescence program, p16INK4a and HMGB2. These proteins are involved in cell cycle arrest and chromatin remodeling during senescence. Circulating levels of these markers increases with age and correlates with functional status...
April 12, 2018: GeroScience
https://www.readbyqxmd.com/read/29629647/immunohistochemical-detection-of-p53-pten-rb-and-p16-in-canine-osteosarcoma-using-tissue-microarray
#10
Duncan S Russell, Lauren Jaworski, William C Kisseberth
Although inactivating mutations of tumor suppressor genes are well described in cell lines of canine osteosarcoma (OS), expression of tumor suppressor proteins in spontaneous disease is poorly characterized. We determined the immunohistochemical expression of p53, PTEN, Rb, and p16 in a large cohort of dogs with OS. Formalin-fixed, paraffin-embedded samples of canine OS were analyzed retrospectively. Primary tumor samples from 145 dogs, collected between 2003 and 2008, were evaluated by tissue microarray. Streptavidin-biotin complex immunohistochemistry was performed using monoclonal antibodies for Rb and PTEN and polyclonal antibodies for p16 and p53...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29625991/t-3-induces-both-markers-of-maturation-and-aging-in-pancreatic-%C3%AE-cells
#11
Cristina Aguayo-Mazzucato, Terence B Lee, Michelle Matzko, Amanda DiIenno, Habib Rezanejad, Preeti Ramadoss, Thomas Scanlan, Ann Marie Zavacki, P Reed Larsen, Anthony Hollenberg, Clark Colton, Arun Sharma, Susan Bonner-Weir
Previously we showed thyroid hormone (T3 ) enhanced β-cell functional maturation through induction of Mafa High levels of T3 have been linked to decreased lifespan in mammals, and low levels to lengthened lifespan, suggesting a relationship between thyroid hormone and aging. Here we show T3 increased p16 Ink4a (a β-cell senescence marker and effector) mRNA in rodent and human β-cells. The kinetics of Mafa and p16 Ink4a induction suggested both genes as targets of thyroid hormone via TH receptor (THR) binding to specific response elements (TRE)...
April 6, 2018: Diabetes
https://www.readbyqxmd.com/read/29619604/prevalence-and-genetic-diversity-of-norovirus-genogroup-ii-in-children-less-than-5-years-of-age-with-acute-gastroenteritis-in-tehran-iran
#12
Mahsa Farsi, Fatemeh Roodbari, Behrooz Nejati, Arash Arashkia, Somayeh Jalilvand, Alireza Nateghian, Aliakbar Rahbarimanesh, Sayed Mahdi Marashi, Zabihollah Shoja
Viral gastroenteritis is a major public health problem worldwide. In Iran, very limited studies have been performed with regard to the epidemiology of noroviruses. This study aimed to evaluate the prevalence and molecular epidemiology of GII noroviruses in hospitalized children less than 5 years of age with acute gastroenteritis (AGE). A total of 210 stool specimens were collected from Ali Asghar Children's Hospital and Bahrami Children's Hospital in Tehran, from June 2015 to June 2016. The samples were screened by real-time RT-PCR for genogroup II (GII)...
April 4, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29617875/genetic-analysis-of-re-emerging-gii-p16-gii-2-noroviruses-in-2016-2017-in-china
#13
Yuanyun Ao, Xin Cong, Miao Jin, Xiaoman Sun, Xiaoman Wei, Jinjin Wang, Qing Zhang, Jiao Song, Jiemei Yu, Jie Cui, Jianxun Qi, Ming Tan, Zhaojun Duan
Background: During 2016-2017, the previously rare GII.P16-GII.2 norovirus suddenly emerged as the predominant genotype causing gastroenteritis outbreaks in China and other countries. Its origin, phylodynamics, and mechanism behind the predominance remain unclear. Methods: Bayesian phylogenetic analyses were performed on 180 full capsid and 150 polymerase sequences of 2016-2017 GII.P16-GII.2 noroviruses in China, and those for all publicly available GII.P16 and GII...
March 29, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29604360/temporal-evolutionary-analysis-of-re-emerging-recombinant-gii-p16_gii-2-norovirus-with-acute-gastroenteritis-in-patients-from-hubei-province-of-china-2017
#14
Jing Li, Ting Zhang, Kun Cai, Yongzhogn Jiang, Xuhua Guan, Jianbo Zhan, Wenjing Zou, Zhaohui Yang, Xuesen Xing, Yang Wu, Yi Song, Xuejie Yu, Junqiang Xu
Norovirus (NoV) is a major pathogenic agent of human acute viral gastroenteritis that occurs worldwide. In March 2017, a series of acute NoV-associated gastroenteritis outbreaks occurred in Hubei Province in central China. Here, we sought to better understand the main genotypes and potential evolutionary advantages of circulating NoV strains underlying these outbreaks. During the outbreak, 111 fecal swabs and stool samples were collected from outpatients with acute NoV-associated gastroenteritis in Hubei Province...
March 28, 2018: Virus Research
https://www.readbyqxmd.com/read/29603831/an-autopsy-case-report-differences-in-radiological-images-correlate-with-histology-in-erdheim-chester-disease
#15
Yuuki Ohara, Seiichi Kato, Daisuke Yamashita, Akira Satou, Yoshie Shimoyama, Chie Hamaie, Motoki Sato, Nobutaro Ban, Koji Yamamoto, Takehiro Yamada, Hisashi Kawai, Koichi Ohshima, Shigeo Nakamura, Shinya Toyokuni
p16 activation caused by oncogenic mutations may represent oncogene-induced senescence (OIS), a protective mechanism against oncogenic events. However, OIS can contribute to tumor development via tissue remodeling in some tumors. Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis, is one such tumor. Its clinical and histological features vary, making it difficult to diagnose. Herein, we describe an autopsy of an ECD patient. The patient underwent radiological examinations, including18 F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), bone scintigraphy and CT...
March 30, 2018: Pathology International
https://www.readbyqxmd.com/read/29600711/jq-1-inhibits-colon-cancer-proliferation-via-suppressing-wnt-%C3%AE-catenin-signaling-and-mir-21
#16
Yan Zhang, Suli Tian, Jidong Xiong, Yongxu Zhou, Hongyu Song, Chang Liu
Bromodoamin and extraterminal (BET) protein inhibitors are a novel class of cancer therapeutics. Here we aim to investigate the efficacy and mechanism of JQ-1, a potent BET inhibitor, in colon cancer therapy. JQ-1 was used to treat SW480 colon cancer mouse xenografts. Tumor size and mouse survival were recorded. Cell apoptosis was evaluated by Annex V-FIC/PI flow cytometry. ChIP-q-PCR analysis was used to assess the H3K27 trimethylation (H3K27m3) of the p16 promoter. Wnt signaling was evaluated by Nkd2 and β-catenin levels...
March 30, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29600625/-effect-of-microrna-34a-sirt1-p53-signal-pathway-on-notoginsenoside-r%C3%A2-delaying-vascular-endothelial-cell-senescence
#17
Xiao-Hua Lai, Yan Lei, Jing Yang, Cheng-Kui Xiu
This study aimed to investigate the effect of notoginsenoside R₁ in delaying H₂O₂-induced vascular endothelial cell senescence through microRNA-34a/SIRT1/p53 signal pathway. In this study, human umbilical vein endothelial cells(HUVECs) were selected as the study object; the aging model induced by hydrogen peroxide(H₂O₂) was established, with resveratrol as the positive drug. HUVECs were randomly divided into four groups, youth group, senescence model group, notoginsenoside R₁ group and resveratrol group...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29599318/lentiviral-vector-mediated-gene-transfer-in-human-bladder-cancer-cell-lines
#18
Wataru Matsunaga, Misa Ichikawa, Azumi Nakamura, Takahiro Ishikawa, Akinobu Gotoh
BACKGROUND/AIM: Currently, treatment of non-muscle invasive bladder cancer causes significant deterioration in a patient's quality of life (QOL). Therefore, development of novel therapeutic options without the deterioration of QOL is very important. In this study, we assessed the anti-tumor effect of lentivirus-mediated gene transfection of tumor-suppressor genes in human bladder cancer cells. MATERIALS AND METHODS: Lentiviral vectors that contained the tumor suppressor genes, p53, p16, and PTEN, were transfected into human bladder cancer cell lines, 5637, T24, 253J, and UMUC3, and the normal human uroepithelial cell line, SV-HUC-1...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29598954/clinical-outcomes-and-prognostic-factors-in-cisplatin-versus-cetuximab-chemoradiation-for-locally-advanced-p16-positive-oropharyngeal-carcinoma
#19
Christian L Barney, Steve Walston, Pedro Zamora, Erin H Healy, Nicole Nolan, Virginia M Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, John C Grecula, Jessica Wobb, Darrion Mitchell, Dukagjin Blakaj, Aashish D Bhatt
OBJECTIVES: Randomized trials evaluating cisplatin versus cetuximab chemoradiation (CRT) for p16+ oropharyngeal cancer (OPC) have yet to report preliminary data. Meanwhile, as a preemptive step toward morbidity reduction, the off-trial use of cetuximab in p16+ patients is increasing, even in those who could potentially tolerate cisplatin. The purpose of this study was to compare the efficacy of cisplatin versus cetuximab CRT in the treatment of p16+ OPC and to identify prognostic factors and predictors of tumor response...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29597056/emergence-of-multiple-norovirus-strains-in-thailand-2015-2017
#20
Thanundorn Thanusuwannasak, Jiratchaya Puenpa, Watchaporn Chuchaona, Sompong Vongpunsawad, Yong Poovorawan
Norovirus is a major cause of non-bacterial acute gastroenteritis worldwide. Infection can be sporadic or result in widespread outbreaks. The surveillance of norovirus samples (n = 1591) obtained from patients with diarrhea in Thailand from January 2015 to February 2017 suggested that the predominance of norovirus GII.4 often seen in sporadic infection had been superseded by the emergence of GII.17. More recently, a sharp increase in acute gastroenteritis associated with norovirus GII·P16-GII.2 recombinant strain was observed at the end of 2016...
March 26, 2018: Infection, Genetics and Evolution
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