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https://www.readbyqxmd.com/read/29050279/ssecks-akap12-scaffolding-functions-suppress-b16f10-induced-peritoneal-metastasis-by-attenuating-cxcl9-10-secretion-by-resident-fibroblasts
#1
Masashi Muramatsu, Lingqiu Gao, Jennifer Peresie, Benjamin Balderman, Shin Akakura, Irwin H Gelman
SSeCKS/Gravin/AKAP12 (SSeCKS) is a kinase scaffolding protein known to suppress metastasis by attenuating tumor-intrinsic PKC- and Src-mediated signaling pathways [1]. In addition to downregulation in metastatic cells, in silico analyses identified SSeCKS downregulation in prostate or breast cancer-derived stroma, suggesting a microenvironmental cell role in controlling malignancy. Although orthotopic B16F10 and SM1WT1[Braf(V600E)] mouse melanoma tumors grew similarly in syngeneic WT or SSeCKS-null (KO) mice, KO hosts exhibited 5- to 10-fold higher levels of peritoneal metastasis, and this enhancement could be adoptively transferred by pre-injecting naïve WT mice with peritoneal fluid (PF), but not non-adherent peritoneal cells (PC), from naïve KO mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049330/the-prevalence-of-human-papillomavirus-in-oropharyngeal-cancer-in-a-new-zealand-population
#2
Rebecca Lucas-Roxburgh, Jackie Benschop, Bruce Lockett, Ursula van den Heever, Ruth Williams, Laryssa Howe
BACKGROUND: The incidence of oropharyngeal cancer (OPC) in New Zealand (NZ) has more than doubled over the last 14 years with 126 cases in 2010. Overseas studies have shown that human papillomavirus (HPV) plays a significant role in the development of these cancers. However, the role of HPV in OPC and the burden on the NZ health system is unclear. AIM: The aim of the study was to determine the prevalence and the genotypes of HPV associated with OPC in New Zealand...
2017: PloS One
https://www.readbyqxmd.com/read/29048733/cytology-and-high-risk-hpv-testing-in-cervical-cancer-screening-program-outcome-of-3-year-follow-up-in-an-academic-institute
#3
Jack Yang, Fredrick S Nolte, Olga S Chajewski, Kathryn G Lindsey, Patricia M Houser, Jalidsa Pellicier, Qun Wang, Laleh Ehsani
BACKGROUND: Combination of cervical cytology and high-risk human papillomavirus (HR-HPV) testing, co-testing, has been increasingly used in screening cervical cancers. The present study summarized the outcome of co-testing by reviewing 3-year clinical and pathological follow-up information. METHODS: Patients were retrospectively identified via computerized search and were grouped based on the cytologic diagnosis and HR-HPV status as negative for intraepithelial lesion or malignancy (NILM)/HPV-, NILM/HPV+, atypical squamous cells of undetermined significance (ASC-US)/HPV-, ASC-US/HPV+, low grade squamous intraepithelial lesion (LSIL)/HPV-, LSIL/HPV+, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H)/HPV-, ASC-H/HPV+, high grade squamous intraepithelial lesion (HSIL)/HPV-, and HSIL/HPV+...
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048728/cytokeratin7-expression-in-histologic-and-cytologic-specimens-of-cystic-neck-metastasis-from-hpv-positive-squamous-cell-carcinoma-of-the-tonsil-a-case-report
#4
Yong Kyun Cho, Seung Ju Lee, Jeong Joo Woo, Hyekyung Lee, Hojung Lee
The majority of cystic squamous cell carcinomas (SCCs) of the neck have been shown to be metastatic tumors from tonsillar SCCs associated with high-risk human papillomavirus (HR HPV). Recent studies have demonstrated cytokeratin (CK)7 involvement in the development of HPV positive SCC, but no report has been issued on its simultaneous expression in primary tonsillar and metastatic tumor with cystic change. We present a case of HPV positive tonsillar SCC of a 42-year-old male that initially manifested as a cystic neck mass expressing CK7, CK19, and p16 in primary and metastatic tumors...
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048673/the-ethanol-extracts-of-sporoderm-broken-spores-of-ganoderma-lucidum-inhibit-colorectal-cancer-in-vitro-and-in-vivo
#5
Kang Li, Kun Na, Tingting Sang, Kaikai Wu, Ying Wang, Xingya Wang
The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activities including anticancer effects. However, the anti-colorectal cancer effects and the potential molecular mechanisms of the ethanol extracts of sporoderm-broken spores of G. lucidum (BSGLEE), which mainly contains triterpenoids, have not been reported. The aim of the present study was to investigate the anticancer effects and molecular mechanisms exerted by BSGLEE on colorectal cancer in vitro and in vivo...
September 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048614/brain-lipid-binding-protein-promotes-proliferation-and-modulates-cell-cycle-in-c6-rat-glioma-cells
#6
Xiao Han, Haoming Li, Ye Zhang, Jianbing Qin, Qingqing Yang, Lu Wang, Mingjie Yuan, Chunlin Xia
Gliomas are the most common primary brain tumors affecting adults. Four grades of gliomas have been identified, namely, grades I-IV. Brain lipid-binding protein (BLBP), which functions in the intracellular transport of fatty acids, is expressed in all grades of human gliomas. The glioma cells that are cultured in vitro are grouped into the BLBP-positive and BLBP-negative cell lines. In the present study, we found that C6 rat glioma cells was a distinct type of BLBP-negative cell line. Our results confirmed that in the C6 cells, the expression of exogenous BLBP increased the proliferation and percentage of cells in the S phase, in the culture medium containing 10 or 1% FBS...
September 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048294/increased-detection-of-emergent-recombinant-norovirus-gii-p16-gii-2-strains-in-young-adults-hong-kong-china-2016-2017
#7
Kirsty Kwok, Sandra Niendorf, Nelson Lee, Tin-Nok Hung, Lok-Yi Chan, Sonja Jacobsen, E Anthony S Nelson, Ting F Leung, Raymond W M Lai, Paul K S Chan, Martin C W Chan
A new recombinant norovirus GII.P16-GII.2 outnumbered pandemic GII.4 as the predominant GII genotype in the winter of 2016-2017 in Hong Kong, China. Half of hospitalized case-patients were older children and adults, including 13 young adults. This emergent norovirus targets a wider age population compared with circulating pandemic GII.4 strains.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047390/roles-of-bccip-deficiency-in-mammary-tumorigenesis
#8
Roberto Droz-Rosario, Huimei Lu, Jingmei Liu, Ning-Ang Liu, Shridar Ganesan, Bing Xia, Bruce G Haffty, Zhiyuan Shen
BACKGROUND: Dysregulated DNA repair and cell proliferation controls are essential driving forces in mammary tumorigenesis. BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The aims of this study were to determine whether BCCIP deficiency contributes to mammary tumorigenesis, especially for a subset of breast cancers with 53BP1 abnormality, and to reveal the mechanistic implications of BCCIP in breast cancer interventions...
October 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29046713/hpv-infection-and-p53-and-p16-expression-in-esophageal-cancer-are-they-prognostic-factors
#9
Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen, Adhemar Longatto-Filho
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that may have impact on survival of ESCC. METHODS: We conducted a prospective cohort study...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29046314/respiratory-dysfunction-following-neonatal-sustained-hypoxia-exposure-during-a-critical-window-of-brainstem-extracellular-matrix-formation
#10
Christopher Stryker, Dominic W Camperchioli, Catherine A Mayer, Warren J Alilain, Richard John Martin, Peter M MacFarlane
The extracellular matrix (ECM) modulates brain maturation and plays a major role in regulating neuronal plasticity during critical periods of development. We examined: 1) whether there is a critical postnatal period of ECM expression in brainstem cardio-respiratory control regions; and 2) if the attenuated hypoxic ventilatory response (HVR) following neonatal sustained (5 days) hypoxia exposure (SH, 11% O2, 24hrs/day) is associated with altered ECM formation. The nucleus tractus solitarius (nTS), dorsal motor nucleus of the vagus (DMNV), the hypoglossal motor nucleus (XII), the cuneate nucleus (CN) and area postrema (AP) were immunofluorescently processed for aggrecan and Wisteria floribunda (WFA) agglutinin, a key proteoglycan of the ECM and the perineuronal net...
October 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29044458/patient-reported-quality-of-life-outcomes-after-de-escalated-chemoradiation-for-human-papillomavirus-positive-oropharyngeal-carcinoma-findings-from-a-phase-2-trial
#11
John V Hegde, Narek Shaverdian, Megan E Daly, Carol Felix, Deborah L Wong, Michael H Rosove, Jordan H Garst, Pin-Chieh Wang, Darlene Veruttipong, Shyam Rao, Ruben C Fragoso, Jonathan W Riess, Michael L Steinberg, Allen M Chen
BACKGROUND: The current study represents a subset analysis of quality-of-life (QOL) outcomes among patients treated on a phase 2 trial of de-escalated chemoradiation for human papillomavirus (HPV)-associated oropharyngeal cancer. METHODS: Eligibility included newly diagnosed, (American Joint Committee on Cancer, 7th edition) stage III or IV oropharyngeal squamous cell carcinoma, p16 positivity, age ≥ 18 years, and a Zubrod performance status of 0 to 1. Treatment was induction paclitaxel at a dose of 175 mg/m(2) and carboplatin at an area under the curve of 6 for 2 cycles followed by response-adapted, dose-reduced radiation of 54 Gy or 60 Gy with weekly concurrent paclitaxel at a dose of 30 mg/m(2) ...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29043437/differences-in-the-prognosis-of-hpv16-positive-patients-with-squamous-cell-carcinoma-of-head-and-neck-according-to-viral-load-and-expression-of-p16
#12
Beata Biesaga, Anna Mucha-Małecka, Anna Janecka-Widła, Marta Kołodziej-Rzepa, Sława Szostek, Dorota Słonina, Aleksandra Kowalczyk, Krzysztof Halaszka, Marcin Przewoźnik
PURPOSE: To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN). MATERIALS AND METHODS: HPV16 presence was assessed in the group of 109 patients with HNSCCs by quantitative polymerase chain reaction (qPCR). VL (assessed by qPCR) and P16 expression (evaluated by immunohistochemistry) were analysed only in the subgroup of HPV16-positive tumours...
October 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29042141/involvement-of-bmi-1-gene-in-the-development-of-gastrointestinal-stromal-tumor-by-regulating-p16-ink4a-p14-arf-gene-expressions-an-in-vivo-and-in-vitro-study
#13
Jiang-Li Wang, Jiang-Hong Wu, Cai Hong, Ya-Nong Wang, Ye Zhou, Zi-Wen Long, Ying Zhou, Hai-Shu Qin
OBJECTIVE: This study was conducted in order to explore the role that Bmi-1 plays during the development of a gastrointestinal stromal tumor (GIST) by regulation of the p16(Ink4A) and p14(ARF) expressions. METHODS: Eighty-six patients diagnosed with GIST were selected to take part in this experiment. The Bmi-1 protein expressions in GIST and adjacent normal tissues were detected using immunohistochemistry and further analyzed by using photodensitometry. To monitor and track the progression of the GIST, a 3-year follow-up was conducted for all affected patients...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29040401/a-young-blood-environment-decreases-aging-of-senile-mice-kidneys
#14
Qi Huang, Yichun Ning, Dong Liu, Ying Zhang, Diangeng Li, Yinping Zhang, Zhong Yin, Bo Fu, Guangyan Cai, Xuefeng Sun, Xiangmei Chen
Whether changes in internal body environment affect kidney aging remains unclear. Specifically, it is unknown whether transplanted kidneys from older donors recover from tissue damage after placement in younger recipients. In this study, a parabiosis animal model was established to investigate the effects of a young internal body environment on aged kidneys. The animals were divided into six groups: young (Ycon) and old (Ocon) control groups, isochronic youth-youth group (Y-IP), elderly-elderly group (O-IP) and heterochronic youth (Y-HP) elderly (O-HP) group...
October 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29039595/caveolin%C3%A2-1-regulates-oxidative-stress%C3%A2-induced-senescence-in-nucleus-pulposus-cells-primarily-via-the-p53-p21-signaling-pathway-in%C3%A2-vitro
#15
Lei Ding, Qingmin Zeng, Jingping Wu, Defang Li, Houlei Wang, Wei Lu, Zengxin Jiang, Guoxiong Xu
Previous studies have indicated that cellular senescence is a critical underlying mechanism of intervertebral disc degeneration. However, the precise mechanism by which cellular senescence accelerates disc degeneration has not been fully elucidated. Caveolin‑1 has recently emerged as an important regulator of cellular senescence. Therefore, the aim of the present study was to investigate whether caveolin‑1 is involved in nucleus pulposus (NP) cellular senescence during oxidative stress. PCR was used to detect caveolin‑1 mRNA expression and protein expression was detected by western blotting...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037027/refining-prognostic-stratification-of-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-different-prognosis-between-t1-and-t2
#16
Sumin Lee, Sang-Wook Lee, Sunmin Park, Sang Min Yoon, Jin-Hong Park, Si Yeol Song, Seung Do Ahn, Jong Hoon Kim, Eun Kyung Choi, Su Ssan Kim, Jinhong Jung, Young Seok Kim
PURPOSE: To validate the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and investigate whether a modified classification better reflects the prognosis. MATERIALS AND METHODS: Medical records of patients diagnosed with non-metastatic HPV-related OPSCC between 2010 and 2016 at a single institution were retrospectively reviewed...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036495/the-p16-mir-217-egr1-pathway-modulates-age-related-tenogenic-differentiation-in-tendon-stem-progenitor-cells
#17
Weifeng Han, Bing Wang, Junpeng Liu, Lei Chen
Previous studies have shown that the differentiation potential declines with the age of progenitor cells and is linked to altered levels of senescence markers. The purpose of this study was to test whether senescence marker p16 affects age-related tenogenic differentiation in tendon stem/progenitor cells (TSPCs). Young and aged TSPCs were isolated from young/healthy and aged/degenerated human Achilles tendons, respectively. Cellular aging and capacity for tenogenic differentiation were examined. The results showed that the tenogenic differentiation capacity of TSPCs significantly decreases with advancing age...
September 27, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29034552/cervical-carcinomas-with-a-micropapillary-component-a-clinicopathological-study-of-8-cases
#18
Colin J R Stewart, M H E Koay, Connull Leslie, Nathan Acott, Yee C Leung
AIMS: Micropapillary carcinomas, or carcinomas with a micropapillary component, are well-recognised in the breast and other anatomical sites. However, they have seldom been described in the cervix. In this report we present a clinicopathological analysis of eight cervical tumours that showed at least a focal (≥5%) component of micropapillary carcinoma. METHODS AND RESULTS: The study group comprised eight cervical carcinomas (4 adenocarcinomas and 4 adenosquamous carcinomas) with a micropapillary component...
October 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29034342/p16-ink4a-expression-in-invasive-laryngeal-cancer
#19
Brenda Y Hernandez, Mobeen Rahman, Charles F Lynch, Wendy Cozen, Elizabeth R Unger, Martin Steinau, Trevor Thompson, Maria Sibug Saber, Sean F Altekruse, Marc T Goodman, Amy Powers, Christopher Lyu, Mona Saraiya
We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29031606/an-acute-gastroenteritis-outbreak-caused-by-gii-p16-gii-2-norovirus-associated-with-airborne-transmission-via-the-aircondition-unit-ventilation-in-a-kindergarten-in-lianyungang-china
#20
Ting-Lu Zhang, Jing Lu, Liang Ying, Xiao-Lu Zhu, Lian-Hao Zhao, Meng-Ying Zhou, Jia-Long Wang, Guo-Cai Chen, Lei Xu
Noroviruses are a common cause of acute gastroenteritis outbreaks in institutions including schools and kindergartens around the world; An outbreak caused by GII.P16-GII.2 norovirus in a kindergarten in Lianyungang, Jiangsu Province, China is reported here. An epidemiological investigation, pathogen detection were performed. Descriptive analysis indicated that this outbreak in middle class 1 was a point source typically. 20 acute gastroenteritis cases occurred only in eight and half hours in this class, the attack rate was 52...
October 11, 2017: International Journal of Infectious Diseases: IJID
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