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Maryna Perepelyuk, Koita Sacko, Karthik Thangavel, Sunday A Shoyele
The objective of this study was to evaluate the therapeutic efficacy and pharmacokinetic study of mucin1-aptamer functionalized miRNA-29b-loaded hybrid nanoparticles (MAFMILHN) in lung tumor-bearing SCID mice. MAFMILHN were manufactured using an iso-electric point based nanotechnology. They were then fully characterized for particle size, loading capacity, Zeta potential and encapsulation efficiency. The ability of MAFMILHN to downregulate oncoprotein DNMT3B both at the cellular level and in vivo was monitored using western blot, while the effect of the downregulation of DNMT3B on tumor growth was assessed using bioluminescence...
February 12, 2018: Molecular Pharmaceutics
Dolors Girbau
PURPOSE: This paper examines whether bilingual children with Specific Language Impairment (SLI) showed limited comprehension of Direct Object (DO) pronoun sentences and/or morphosyntactic priming compared to children with Typical Language Development (TLD) and adults. We analyzed the relation of these morphosyntactic processes to other psycholinguistic abilities, according to the MUC (Memory-Unification-Control) model. METHOD: Ten bilingual native Spanish-speaking children with SLI (8;3-10;6) and 10 age-matched children with TLD (7;6-10;10) received a psycholinguistic evaluation in Spanish-English...
February 2, 2018: Journal of Communication Disorders
Dariusz Waniczek, Mirosław Śnietura, Zbigniew Lorenc, Ewa Nowakowska-Zajdel, Małgorzata Muc-Wierzgoń
In certain patients with advanced colorectal cancer, loss of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) activity is observed. PTEN is a major gatekeeper gene of the AKT serine/threonine kinase (AKT) signaling pathway responsible for the proliferative activity of cells. The assessment of AKT activity may be a prognostic factor or a predictor of response to the targeted therapies against particular signaling proteins. To precisely identify the cause and the place of the pathway deregulation, it is necessary to identify phosphorylation states and concentrations of several proteins located at different levels of the regulatory cascade...
January 2018: Oncology Letters
F Drakopanagiotakis, Lukasz Wujak, Malgorzata Wygrecka, P Markart
Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure and ultimately to death. Being the prototype of interstitial lung diseases, IPF is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, we still cannot reliably predict the course of the disease and the response to treatment of an individual patient. Non-invasive biomarkers, in particular serum biomarkers, for the (early) diagnosis, differential diagnosis, prognosis and prediction of therapeutic response are urgently needed...
January 30, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Aleksander Muc, Marek Barski
A microstructure-based model is developed to study the effective anisotropic properties (magnetic, dielectric or thermal) of two-phase particle-filled composites. The Green's function technique and the effective field method are used to theoretically derive the homogenized (averaged) properties for a representative volume element containing isolated inclusion and infinite, chain-structured particles. Those results are compared with the finite element approximations conducted for the assumed representative volume element...
February 3, 2018: Materials
Charlotte Leclaire, Karine Lecointe, Patrick A Gunning, Sandra Tribolo, Devon W Kavanaugh, Alexandra Wittmann, Dimitrios Latousakis, Donald A MacKenzie, Norihito Kawasaki, Nathalie Juge
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein-carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell-based approaches to decipher the specificity of the interaction between mucin glycans and mammalian lectins expressed in the gut, including galectin (Gal)-3 and C-type lectin receptors. Gal-3 differentially recognized intestinal mucins with different O-glycosylation profiles, as determined by mass spectrometry (MS). Modification of mucin glycosylation, via chemical treatment leading to a loss of terminal glycans, promoted the interaction of Gal-3 to poly- N-acetyllactosamine...
January 29, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
James Luke Godwin, Jean Hoffman-Censits, Elizabeth Plimack
Urothelial carcinoma of the bladder is a common malignancy which has historically been difficult to treat in its advanced stages. Clinically effective treatment options for locally advanced/inoperable or metastatic urothelial carcinoma (mUC) consisted of cisplatin-based chemotherapy regimens, with few other impactful therapeutic options. The past 2 years have seen a remarkable shift in the therapeutic landscape of mUC, with 5 novel immunotherapy agents receiving FDA approval for mUC, including first-line and second-line postplatinum settings...
January 26, 2018: Urologic Oncology
Steven M Yip, Jeenan Kaiser, Haocheng Li, Scott North, Daniel Y C Heng, Nimira S Alimohamed
INTRODUCTION: In the first- and second-line metastatic urothelial carcinoma (mUC) treatment setting, we investigated real-world outcomes and evaluated the prognostic role of neutrophil to lymphocyte ratio (NLR). METHODS: A retrospective analysis was performed on patients with mUC treated with systemic therapy. Overall response rates (ORRs), median time to treatment failure (mTTF), and median overall survival (mOS) were calculated. The association between baseline NLR (using a literature-derived cut-off of 3, as well as the best cut-off NLR value of 5...
December 29, 2017: Clinical Genitourinary Cancer
Shinji Tsutsumi, Akihiko Murata, Yoichi Yamauchi, Kensuke Okano, Hiroshi Yokoyama, Akitoshi Kimura, Yoshiya Ishizawa, Minoru Umehara, Masashi Kato, Naoki Hashimoto, Yutaka Umehara, Shinsuke Nishikawa, Kenichi Takahashi, Takayuki Morita
A 74-year-oldwoman hadconsultedthe department of urology in our hospital because of microscopic hematuria. Cystoscopy revealeda urinary bladder tumor, suspectedas an adenocarcinoma basedon biopsy. MRI showeda cystic tumor of the appendix with vesical fistula; therefore, she underwent an operation with a diagnosis of appendiceal cancer invading the urinary bladder. During the operation, we found that the appendix sunk into the urinary bladder with right adnexa. Therefore, we performed ileocecal resection, partial resection of the urinary bladder, and right adnexectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Emily R Thompson, Sarah A Hosgood, Michael L Nicholson, Colin H Wilson
BACKGROUND: Kidney transplantation is the treatment of choice for patients with end-stage kidney disease. In a previous review we concluded that the routine use of ureteric stents in kidney transplantation reduces the incidence of major urological complications (MUC). Unfortunately, this reduction appears to lead to a concomitant rise in urinary tract infections (UTI). For kidney recipients UTI is now the commonest post-transplant complication. This represents a considerable risk to the immunosuppressed transplant recipient, particularly in the era of increased immunologically challenging transplants...
January 29, 2018: Cochrane Database of Systematic Reviews
Sulen Sarioglu, Guray Akturk, Selman Sokmen, Hulya Ellidokuz, Aras Emre Canda, Mehtat Unlu, Abdullah Haluk Sirin, Ozgul Sagol, Cem Terzi, Mehmet Fuzun
PURPOSE: Colon mucinous carcinomas (MUCs) have two morphological patterns: (i) glands lined by mucinous epithelium with direct contact to the stroma (FIX) and (ii) carcinoma cells floating in mucin (FLO). In this study, we evaluated the prognostic value of these patterns. METHODS: Digital images were captured from the 38 MUC's tissue sections. A grid with 140 points was laid over the computer screen. Totally, 100 points, falling on tumor cells floating in mucin (FLO patterned cells) or on cells contacting stroma (FIX patterned cells), were counted...
January 29, 2018: Journal of Gastrointestinal Cancer
Husamettin Aygun, Murat Karamese, Cem Ozic, Fikret Uyar
AIM: Adherent-invasive Escherichia coli (AIEC) pathovar has been identified in intestinal mucosa of patients with Crohn's disease. Our aim was to compare the impact of sterile mucosal media (Muc-M) originated from different parts of the intestine on some pathogenic traits of AIEC LF82 strain. MATERIALS & METHODS: Muc-M composed of certain rates of cell culture medium or M63 minimal medium and mucosal contents obtained from different part of intestine were designed for cell-infection experiments and biofilm-formation assays...
January 5, 2018: Future Microbiology
Irean Garcia Hernandez, Mauricio Canavati Marcos, Margarita Garza Montemayor, Dulce Lopez Sotomayor, Diana Pineda Ochoa, Gabriela Sofia Gomez Macias
INTRODUCTION: Mucinous carcinoma is a variant of invasive breast carcinomas that accounts for 2% of them and has a better prognosis in contrast to the non-specific invasive carcinoma. They regularly are positive for estrogen and progesterone receptors and, generally, they do not overexpress HER2. When HER2 is positive, the first line treatment is trastuzumab; although the resistance is 52-89% for the non-specific carcinoma, it has been described just once in mucinous carcinoma. CASE SUMMARY: A 48-year-old female presented with a lump in her right breast and after a biopsy, it was diagnosed as mucinous carcinoma in the core biopsy and surgical resection, with positive hormone receptors and HER2 positive (3+) in 100% of the tumor cells...
December 26, 2017: International Journal of Surgery Case Reports
Elżbieta Grochowska-Niedworok, Marek Kardas, Edyta Fatyga, Karolina Piórkowska-Staniek, Małgorzata Muc-Wierzgoń, Teresa Kokot
AIM: This study assessed the nutritional status and physical activity levels of 150 female students aged 10-18 from three top Polish ballet schools, where the most promising dancers go on to pursue professional ballet careers. METHODS: We analysed the girls' body composition, physical activity level (PAL) and PAL coefficient. The ballet students also completed a questionnaire. RESULTS: The results revealed large deficiencies in the body weight and body fat of the young ballerinas...
December 28, 2017: Acta Paediatrica
Jose Luis Perez-Gracia, Yohann Loriot, Jonathan E Rosenberg, Thomas Powles, Andrea Necchi, Syed A Hussain, Rafael Morales-Barrera, Margitta M Retz, Günter Niegisch, Ignacio Durán, Christine Théodore, Enrique Grande, Xiaodong Shen, Jingjing Wang, Betty Nelson, Christina L Derleth, Michiel S van der Heijden
BACKGROUND: Patients with metastatic urothelial carcinoma (mUC) who progress after platinum-based chemotherapy have had few treatment options and uniformly poor outcomes. Atezolizumab (anti-programmed death-ligand 1) was approved in the USA for cisplatin-ineligible and platinum-treated mUC based on IMvigor210, a phase 2, single-arm, two-cohort study. OBJECTIVE: To evaluate the efficacy and safety of atezolizumab by the number of prior lines of systemic therapy in patients with pretreated mUC...
December 19, 2017: European Urology
Magdalena Kwiatosz-Muc, Anna Fijałkowska-Nestorowicz, Magdalena Fijałkowska, Anna Aftyka, Michał Kowalczyk
BACKGROUND: High stress levels have been commonly reported among ICU workers. Currently, anaesthesiology is safer for the patient but more stressful for the staff working in this branch of medicine. ICU and anaesthesiology personnel are prone to stress because of the specific character of their work. OBJECTIVES: Our objectives were to assess stress prevalence among anaesthesiology and ICU workers to compare this stress prevalence in relation to professional groups, sex, job seniority, and type of hospital and describe the importance of major stressors at work...
December 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Futoshi Muranaka, Tomoyuki Nakajima, Mai Iwaya, Keiko Ishii, Kayoko Higuchi, Naoko Ogiwara, Shinichi Miyagawa, Hiroyoshi Ota
To better understand the cellular origins and differentiation of anal canal epithelial neoplasms, the immunohistochemical profiles of the anal canal epithelium in humans and swine were evaluated. Formalin-fixed tissue sections were immunostained for mucin (MUC: MUC2, MUC5AC, MUC5B), desmoglein 3 (DGS3), p63, CDX2, SOX2, and α-smooth muscle actin (α-SMA). The anal transitional zone (ATZ) epithelium covered the anal sinus and consisted of a stratified epithelium with mucous cells interspersed within the surface lining...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Hao Lu, Dan Liang, Yun Zhu, Wanlin Xu, Kaihua Zhou, Limin Liu, Shengwen Liu, Wenjun Yang
The prognostic value of mucins expression in patients with head and neck cancer (HNC) remains controversial. To address this, a meta-analysis was performed to systematically evaluate prognostic significance of mucins expression in HNC. Electronic and manual searches were performed and a total of 20 studies including 2046 patients were selected for the final analysis. Increased mucins expression was associated with unfavorable overall survival in HNC patients (HR=1.83, 95% CI: 1.43-2.33, p=0.000). Mucins overexpression was also in correlation with more advanced TNM stage (RR=0...
November 10, 2017: Oncotarget
Samuel Mon-Wei Yu, Anthony J Bleyer, Kisra Anis, Leal Herlitz, Martina Živná, Helena Hůlková, Glen S Markowitz, Belinda Jim
Mucin 1 kidney disease, previously referred to as medullary cystic kidney disease type 1, is a rare hereditary kidney disease. It is one of several diseases now termed autosomal dominant tubulointerstitial kidney disease, as proposed by a KDIGO (Kidney Disease: Improving Global Outcomes) consensus report in 2014. Autosomal dominant tubulointerstitial kidney diseases share common clinical findings, such as autosomal dominant inheritance, bland urinary sediment, absent to mild proteinuria, and progressive loss of kidney function...
December 4, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Raúl Omar Quintana-Belmares, Annette M Krais, Bahare Kourangi Esfahani, Irma Rosas-Pérez, Daniel Mucs, Rebeca López-Marure, Åke Bergman, Ernesto Alfaro-Moreno
Endocrine disrupting chemicals (EDCs) from the environment are associated with reproductive abnormalities (i.e. decreased sperm concentration; increased endometriosis) and alterations of the cardiovascular system (i.e. increased blood pressure and risk of coronary disease). Some phthalates esters have been identified as EDCs, for which inhalation is considered as one of the routes of exposure. However, only little is known regarding inhalational exposure to EDCs via urban airborne particles. In the present study, we report the monthly concentration of 8 phthalate esters measured in PM10 and PM2...
December 4, 2017: Environmental Research
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