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https://www.readbyqxmd.com/read/29649474/mucin-and-carbon-nanotube-based-biosensor-for-detection-of-glucose-in-human-plasma
#1
Fausto N Comba, Marcelo R Romero, Fernando S Garay, Ana M Baruzzi
This work reports an amperometric enzyme-electrode prepared with glucose oxidase, which have been immobilized by a cross-linking step with glutaraldehyde in a mixture containing albumin and a novel carbon nanotubes-mucin composite (CNT-muc). The obtained hydrogel matrix was trapped between two polycarbonate membranes and then fixed at the surface of a Pt working electrode. The developed biosensor was optimized by evaluating different compositions and the analytical properties of an enzymatic matrix with CNT-muc...
April 9, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29648578/gastric-adenocarcinoma-of-the-fundic-gland-type-update-and-literature-review
#2
Mark A Benedict, Gregory Y Lauwers, Dhanpat Jain
Objectives: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described entity with a lack of awareness amongst general surgical pathologists and this review highlights the key features and controversies associated with this uncommon neoplasm. Methods: A literature search through PubMed using synonyms for GA-FG was conducted to obtain 111 cases. Results: GA-FG is a well-differentiated neoplasm of oxyntic mucosa, that is comprised of chief cells and parietal cells...
April 10, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29623487/atezolizumab-in-metastatic-urothelial-carcinoma-outside-clinical-trials-focus-on-efficacy-safety-and-response-to-subsequent-therapies
#3
Pedro C Barata, Dhrmesh Gopalakrishnan, Vadim S Koshkin, Prateek Mendiratta, Matt Karafa, Kimberly Allman, Allison Martin, Jennifer Beach, Pam Profusek, Allison Tyler, Laura Wood, Moshe Ornstein, Timothy Gilligan, Brian I Rini, Jorge A Garcia, Petros Grivas
BACKGROUND: Little is known about the outcomes, safety, and response to subsequent therapies of patients with metastatic urothelial carcinoma (mUC) treated with atezolizumab outside clinical trials. OBJECTIVES: The objectives of the study include to report the clinical efficacy and safety of atezolizumab, and the response to future therapies in clinical practice outside clinical trials. PATIENT AND METHODS: This is a retrospective, single-center study including consecutive patients with confirmed mUC who received at least one dose of atezolizumab 1200 mg every 3 weeks between May 2016 and April 2017...
April 6, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29619374/modulation-of-molecular-biomarker-expression-in-response-to-chemotherapy-in-invasive-ductal-carcinoma
#4
Mana Oloomi, Neda Moazzezy, Saeid Bouzari
Breast cancer (BC) has varied morphological and biological features and is classified based on molecular and morphological examinations. Molecular classification of BC is based on biological gene-expression profiling. In this study, biomarker modulation was assessed during BC treatment in 30 previously untreated patients. Heterogeneity among patients was pathologically diagnosed and classified into luminal and basal-like immunohistochemical profiles based on estrogen, progesterone, and human epidermal growth factor receptor (ER/PR/HER2) status...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29606979/pd-1-and-pd-l1-inhibitors-after-platinum-based-chemotherapy-or-in-first-line-therapy-in-cisplatin-ineligible-patients-dramatic-improvement-of-prognosis-and-overall-survival-after-decades-of-hopelessness-in-patients-with-metastatic-urothelial-cancer
#5
REVIEW
Irene Resch, Shahrokh F Shariat, Kilian M Gust
Until recently, there were no true innovations in the management of locally advanced (aUC) and metastatic urothelial cancer (mUC) in the last three decades. Vinflunine has been approved by the EMA (European Medicines Agency) with only limited improvement compared to best supportive care in second line treatment. In addition, gemcitabine/cisplatin has been established as an alternative to methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC). The advent of checkpoint inhibitors (CPI) revolutionized the care of these patients, transforming a unanimously deadly disease into one with hope through sustained disease control...
2018: Memo
https://www.readbyqxmd.com/read/29600445/tumor-lysate-based-vaccines-on-the-road-to-immunotherapy-for-gallbladder-cancer
#6
REVIEW
Daniel Rojas-Sepúlveda, Andrés Tittarelli, María Alejandra Gleisner, Ignacio Ávalos, Cristián Pereda, Iván Gallegos, Fermín Eduardo González, Mercedes Natalia López, Jean Michel Butte, Juan Carlos Roa, Paula Fluxá, Flavio Salazar-Onfray
Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, suggesting that in combination with active immunizations, such as cancer vaccines, they could be helpful to improve response rates. During the last decade, we have used dendritic cell (DC) based vaccines where DCs loaded with an allogeneic heat-conditioned melanoma cell lysate were tested in a series of clinical trials...
March 29, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29587323/-immune-checkpoint-inhibition-in-metastatic-urothelial-carcinoma
#7
Jens Bedke, Tilman Todenhöfer, Arnulf Stenzl
The treatment of metastatic urothelial carcinoma is characterized by the administration of combinatory regimes of chemotherapy. In the first-line treatment theses regimes demonstrate relatively good objective response rates and prolongation of overall survival. The prognosis declines if the patient is refractory to platin in the second- or third-line treatment or if the patient is ineligible for cisplatin in the first-line setting. Cisplatin ineligibility is defined by a poor renal function or subsequent comorbidities...
April 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29581623/a-case-of-local-recurrence-of-t1-rectal-cancer-10-years-after-transanal-excision
#8
Hideharu Tanaka, Koji Komori, Takashi Kinoshita, Taihei Oshiro, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuichi Ito, Norihisa Uemura, Seiji Natsume, Eiji Higaki, Akira Ouchi, Masayuki Tsutsuyama, Takahiro Hosoi, Itaru Shigeyoshi, Byonggu An, Tomoyuki Akazawa, Daisuke Hayashi, Tairin Uchino, Aina Kunitomo, Yasuhiro Shimizu
We report a case of a patient with T1 rectal cancer, which recurred locally after 10 years from the primary operation. A 78-year-old woman was diagnosed with rectal cancer. Transanal excision (TAE) was performed in December 2006. The pathological findings revealed stage I rectal cancer [tub2>muc, pSM (2,510 µm), ly0, v0, pHM0, pVM0]. Because she did not opt for additional treatment, she received follow-up examination. After approximately 10 years from the primary operation, she presented to her physician, complaining of melena, and she was referred to our hospital again in November 2016...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29574929/impact-of-histological-subtype-on-the-prognosis-of-patients-undergoing-surgery-for-colon-cancer
#9
Fabio Bagante, Gaya Spolverato, Eliza Beal, Katiuscha Merath, Qinyu Chen, Ozgür Akgül, Robert A Anders, Timothy M Pawlik
BACKGROUND: The effect of the histological subtype on the prognosis of patients undergoing surgery for colon cancer (CC) is not completely understood. METHODS: The Surveillance, Epidemiology, and End Results (SEER) 2004-2014 database was used to compare the long-term outcomes of patients undergoing colon resection for classical adenocarcinoma (CA), mucinous adenocarcinoma (MUC), and signet-cell adenocarcinoma (SC). RESULTS: A total of 153 317 (89%) patients had CA, 16 660 (10%) MUC while 1810 (1%) patients had SC subtype...
March 25, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29561438/small-intestinal-obstruction-due-to-the-metastasis-of-intrahepatic-cholangiocarcinoma-a-case-report
#10
Shintaro Akiyama, Masakazu Nagahori, Shinya Oooka, Mariko Negi, Takashi Ito, Kento Takenaka, Kazuo Ohtsuka, Mamoru Watanabe
RATIONALE: The small intestine (SI) does not commonly harbor cancer but is occasionally involved by metastatic cancer from other organs. To manage SI cancer appropriately, surveillance for primary origin outside the SI is essential. PATIENT CONCERNS: This study presents a 54-year-old Thai man diagnosed with SI obstruction which required laparoscopy- assisted partial ileal resection. DIAGNOSES: On the basis of the expression pattern of cytokeratins (CKs) and mucins (MUCs) in the resected SI adenocarcinoma, we suspected this was metastasized from the pancreatobiliary tract...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29555328/blend-of-organic-acids-and-medium-chain-fatty-acids-prevents-the-inflammatory-response-and-intestinal-barrier-dysfunction-in-mice-challenged-with-enterohemorrhagic-escherichia-coli-o157-h7
#11
Jun Wang, JinXin Lu, XiaoWei Xie, Jia Xiong, Ningning Huang, Hongkui Wei, Siwen Jiang, Jian Peng
Impaired epithelial barrier function disrupts immune homeostasis and increases inflammation in intestines, leading to many intestinal diseases. The blend of organic acids (OAs) and medium chain fatty acids (MCFAs) has been shown to have synergistic bactericidal effect. In this study, we demonstrated that two blends of OAs and MCFAs (OM1 and OM2) could prevent the inflammatory response and intestinal barrier dysfunction in enterohemorrhagic Escherichia coli (EHEC)-infected mice. Treatments of OM1 and OM2 significantly reduced the body weight loss and production of IL-6 and TNF-α induced by EHEC...
March 16, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29517810/characterization-of-metastatic-urothelial-carcinoma-via-comprehensive-genomic-profiling-of-circulating-tumor-dna
#12
Neeraj Agarwal, Sumanta K Pal, Andrew W Hahn, Roberto H Nussenzveig, Gregory R Pond, Sumati V Gupta, Jue Wang, Mehmet A Bilen, Gurudatta Naik, Pooja Ghatalia, Christopher J Hoimes, Dharmesh Gopalakrishnan, Pedro C Barata, Alexandra Drakaki, Bishoy M Faltas, Lesli A Kiedrowski, Richard B Lanman, Rebecca J Nagy, Nicholas J Vogelzang, Kenneth M Boucher, Ulka N Vaishampayan, Guru Sonpavde, Petros Grivas
BACKGROUND: Biomarker-guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available are not eligible. Technological advancements in sequencing have made cell-free circulating DNA (cfDNA) next-generation sequencing (NGS) readily available in the clinic. The objective of the current study was to determine whether the genomic profile of mUC detected by NGS of cfDNA is similar to historical tumor tissue NGS studies...
March 8, 2018: Cancer
https://www.readbyqxmd.com/read/29497822/a-retrospective-comparative-study-evaluating-the-efficacy-of-adding-intra-arterial-methotrexate-infusion-to-uterine-artery-embolisation-followed-by-curettage-for-cesarean-scar-pregnancy
#13
Ling Gao, Yan-Yan Hou, Feng Sun, Wei Xia, Yi Yang, Tian Tian, Qin-Fang Chen, Xiao-Cui Li
PURPOSE: The study aimed to compare the efficacy of intra-arterial methotrexate (MTX) infusion combined with uterine artery embolisation (UAE) and uterine curettage with that of UAE and curettage without MTX infusion for the treatment of cesarean scar pregnancy (CSP). METHODS: In this retrospective study, data of CSP patients admitted from January 2011 to July 2015 were obtained from electronic patient records. Clinical information at baseline and after treatment were extracted and analyzed...
March 1, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29488297/photomodulating-gene-expression-by-using-caged-sirnas-with-single-aptamer-modification
#14
Liangliang Zhang, Changmai Chen, Xinli Fan, Xinjing Tang
Caged siRNAs incorporating terminal modification were rationally designed for photochemical regulation of gene silencing induced by RNA interference (RNAi). Through the conjugation of a single oligonucleotide aptamer at the 5' terminus of the antisense RNA strand, enhancement of the blocking effect for RNA-induced silencing complex (RISC) formation/processing was expected, due both/either to the aptamers themselves and/or to their interaction with large binding proteins. Two oligonucleotide aptamers (AS1411 and MUC-1) were chosen for aptamer-siRNA conjugation through a photolabile linker...
February 28, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29484836/primary-murine-mucosal-response-during-cephalosporin-induced-intestinal-colonization-by-enterococcus-faecium
#15
Antoni P A Hendrickx, Denise van de Kamer, Rob J L Willems
Hospitalized patients are often administered antibiotics that perturb the gastrointestinal commensal microbiota, leading to outgrowth of antibiotic-resistant bacteria, like multidrug-resistant Enterococcus faecium, subsequent spread, and eventually infections. However, the events that occur at the initial stage of intestinal colonization and outgrowth by multidrug-resistant E. faecium within the antibiotic-treated host have not been thoroughly studied. Here, we describe and visualize that only 6 hr after cephalosporin treatment of mice, the Muc-2 mucus layer is reduced and E-cadherin junctions were altered...
February 27, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29478735/atezolizumab-in-platinum-treated-locally-advanced-or-metastatic-urothelial-carcinoma-clinical-experience-from-an-expanded-access-study-in-the-united-states
#16
Sumanta Kumar Pal, Jean Hoffman-Censits, Hanzhe Zheng, Constanze Kaiser, Darren Tayama, Joaquim Bellmunt
BACKGROUND: Atezolizumab (anti-programmed death-ligand 1) was approved in the USA, Europe, and elsewhere for treatment-naive and platinum-treated locally advanced/metastatic urothelial carcinoma (mUC). OBJECTIVE: To report efficacy and safety from an atezolizumab expanded access study. DESIGN, SETTING, AND PARTICIPANTS: This single-arm, open-label study enrolled 218 patients at 36 US sites. Key eligibility criteria included progression during/following ≥1 platinum-based chemotherapy for mUC or in perioperative setting (progression within 12 mo) and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-2...
February 22, 2018: European Urology
https://www.readbyqxmd.com/read/29476023/genomic-enabled-prediction-kernel-models-with-random-intercepts-for-multi-environment-trials
#17
Jaime Cuevas, Italo Granato, Roberto Fritsche-Neto, Osval A Montesinos-Lopez, Juan Burgueño, Massiane B E Sousa, José Crossa
In this study, we compared the prediction accuracy of the main genotypic effect model (MM) without G×E interactions, the multi-environment single variance G×E deviation model (MDs), and the multi-environment environment-specific variance G×E deviation model (MDe) where the random genetic effects of the lines are modeled with the markers (or pedigree). With the objective of further modeling the genetic residual of the lines, we incorporated the random intercepts of the lines (l) and generated another three models ...
February 23, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29456726/association-of-histone-deacetylase-expression-with-histology-and-prognosis-of-ovarian-cancer
#18
Mitsutake Yano, Masanori Yasuda, Mika Sakaki, Koji Nagata, Takashi Fujino, Eiichi Arai, Takahiro Hasebe, Masaki Miyazawa, Mariko Miyazawa, Naoki Ogane, Kosei Hasegawa, Hisashi Narahara
Histone deacetylase (HDAC) inhibitor is known to have a cytotoxic effect on ovarian cancer cell lines. The present study analyzed the association between immunohistochemical HDAC expression and clinicopathological findings, in particular, the association with histological type and effect of chemotherapy. The histology of the 201 ovarian cancers addressed was as follows: Serous carcinoma (SEC), 100 cases; clear cell carcinoma (CCC), 56 cases; endometrioid carcinoma (EMC), 36 cases; and mucinous carcinoma (MUC), 9 cases...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432024/evaluation-of-muc-1-aptamer-functionalized-hybrid-nanoparticles-for-targeted-delivery-of-mirna-29b-to-non-small-cell-lung-cancer
#19
Maryna Perepelyuk, Koita Sacko, Karthik Thangavel, Sunday A Shoyele
The objective of this study was to evaluate the therapeutic efficacy and pharmacokinetic study of mucin1-aptamer functionalized miRNA-29b-loaded hybrid nanoparticles (MAFMILHN) in lung tumor-bearing SCID mice. MAFMILHN were manufactured using an iso-electric point based nanotechnology. They were then fully characterized for particle size, loading capacity, Zeta potential and encapsulation efficiency. The ability of MAFMILHN to downregulate oncoprotein DNMT3B both at the cellular level and in vivo was monitored using western blot, while the effect of the downregulation of DNMT3B on tumor growth was assessed using bioluminescence...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29426787/direct-object-pronoun-sentence-processing-in-spanish-english-children-with-without-specific-language-impairment-and-adults-a-cross-modal-priming-study
#20
Dolors Girbau
PURPOSE: This paper examines whether bilingual children with Specific Language Impairment (SLI) showed limited comprehension of Direct Object (DO) pronoun sentences and/or morphosyntactic priming compared to children with Typical Language Development (TLD) and adults. We analyzed the relation of these morphosyntactic processes to other psycholinguistic abilities, according to the MUC (Memory-Unification-Control) model. METHOD: Ten bilingual native Spanish-speaking children with SLI (8;3-10;6) and 10 age-matched children with TLD (7;6-10;10) received a psycholinguistic evaluation in Spanish-English...
February 2, 2018: Journal of Communication Disorders
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