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https://www.readbyqxmd.com/read/27924608/a-method-to-isolate-purify-and-characterize-human-periodontal-ligament-stem-cells
#1
Krzysztof Mrozik, Stan Gronthos, Songtao Shi, P Mark Bartold
Human periodontal ligament stem cells (PDLSCs) are a unique population of mesenchymal stem cells (MSCs) that demonstrate the capacity to generate cementum- and periodontal ligament-like structures in vivo. As such, PDLSCs represent a promising cell-based therapy in reconstructive dentistry for the treatment of periodontal disease. The present chapter describes two methods for isolating PDLSCs from human PDL tissue including traditional plastic adherence, and immunomagnetic selection based on the expression of MSC-associated surface markers STRO-1 antigen, CD146 (MUC-18), CD29 (Integrin β-1), CD44, and CD106 (VCAM-1)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27923652/mir-211-inhibits-invasion-and-epithelial-to-mesenchymal-transition-emt-of-cervical-cancer-cells-via-targeting-muc4
#2
Dongkui Xu, Shikai Liu, Liang Zhang, Lili Song
The dysregulated molecules and their involvement in lymph node metastases of cervical cancer are far from been fully revealed. In this study, by reviewing MUC4 expression in The Human Protein Atlas and retrieving gene microarray data in GEO dataset (No. GDS4664), we found that MUC4 upregulation is associated with lymph node metastasis in cervical cancer. Knockdown of MUC4 in Hela and SiHa cells significantly reduced their invasion and also reduced the mesenchymal properties. By performing bioinformatics analysis, we observed that miR-211 is a potential suppressor of MUC4, which has a predicted highly conserved binding site in the 3'UTR of MUC among mammals...
December 3, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27893426/sublethal-exposure-to-alpha-radiation-223ra-dichloride-enhances-various-carcinomas-sensitivity-to-lysis-by-antigen-specific-cytotoxic-t-lymphocytes-through-calreticulin-mediated-immunogenic-modulation
#3
Anthony S Malamas, Sofia R Gameiro, Karin M Knudson, James W Hodge
Radium-223 dichloride (Xofigo®; 223Ra) is an alpha-emitting radiopharmaceutical FDA-approved for the treatment of bone metastases in patients with advanced castration-resistant prostate cancer. It is also being examined clinically in patients with breast and lung carcinoma and patients with multiple myeloma. As with other forms of radiation, the aim of 223Ra is to reduce tumor burden by directly killing tumor cells. External beam (photon) and proton radiation have been shown to augment tumor sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes (CTLs)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890438/short-term-clinical-results-of-frozen-shoulder-treated-with-shoulder-manipulation-under-ultrasound-guided-cervical-nerve-root-block-at-outpatient-setting-a-case-series
#4
Tomohiro Saito, Hideyuki Sasanuma, Yuki Iijima, Yuji Kanaya, Toshihiro Saito, Hideaki Watanabe, Ichiro Kikkawa, Katsushi Takeshita
BACKGROUND: We evaluated the short-term clinical outcomes of frozen shoulder treatment via shoulder manipulation under ultrasound-guided cervical nerve root block (MUC). METHODS: This study included frozen shoulder patients who were unresponsive to conservative therapy for at least 6 months and were then treated with MUC. Patients with a rotator cuff tear, calcifying tendinitis, osteoarthritis, or any other shoulder disorder were excluded following X-ray, ultrasound, and magnetic resonance imaging evaluation...
November 25, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27795812/mucins-in-neoplasms-of-pancreas-ampulla-of-vater-and-biliary-system
#5
REVIEW
Dimitrios Moschovis, Giorgos Bamias, Ioanna Delladetsima
Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN)...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27778475/abstracts-of-the-25th-malaysian-urological-conference-muc-2016-malaysia-25-november-2016
#6
(no author information available yet)
No abstract text is available yet for this article.
November 2016: BJU International
https://www.readbyqxmd.com/read/27764813/targeting-heterogeneity-of-adrenocortical-carcinoma-evaluation-and-extension-of-preclinical-tumor-models-to-improve-clinical-translation
#7
Constanze Hantel, Igor Shapiro, Giada Poli, Costanza Chiapponi, Martin Bidlingmaier, Martin Reincke, Michaela Luconi, Sara Jung, Felix Beuschlein
In recent years it has been recognized that clinical translation of novel therapeutic strategies for patients with adrenocortical carcinoma (ACC) often fails. These disappointing results indicate that the currently utilized tumor models only poorly reflect relevant pathophysiology and, thereby, do not predict clinical applicability of novel pharmacological approaches. However, also the development of new preclinical ACC models has remained a challenge with only one human cell line (NCI-H295R) and one recently established human pediatric xenograft model (SJ-ACC3) being available for this highly heterogeneous malignancy...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733047/paradox-ca-15-3-increase-in-metastatic-breast-cancer-patients-treated-with-everolimus-a-change-of-paradigm-in-a-case-series
#8
Armando Orlandi, Carmela Di Dio, Maria Alessandra Calegari, Carlo Barone
Everolimus and exemestane represent a standard treatment for metastatic hormone receptor-positive/HER2-negative advanced breast cancer resistant to aromatase inhibitors. CA 15-3 serum levels detect soluble forms of MUC-1, a transmembrane oncoprotein aberrantly overexpressed in breast cancers. In clinical practice, CA 15-3 may be used to indicate treatment failure in the absence of readily measurable disease during cytotoxic therapy. In the targeted therapy era, it is important to note that the C-terminal subunit of MUC-1 interacts with PI3K/AKT pathway, inducting cell growth...
October 13, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27729234/tumor-reference-resolution-and-characteristic-extraction-in-radiology-reports-for-liver-cancer-stage-prediction
#9
Wen-Wai Yim, Sharon W Kwan, Meliha Yetisgen
BACKGROUND: Anaphoric references occur ubiquitously in clinical narrative text. However, the problem, still very much an open challenge, is typically less aggressively focused on in clinical text domain applications. Furthermore, existing research on reference resolution is often conducted disjointly from real-world motivating tasks. OBJECTIVE: In this paper, we present our machine-learning system that automatically performs reference resolution and a rule-based system to extract tumor characteristics, with component-based and end-to-end evaluations...
December 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27669173/dietary-enrichment-with-20-fish-oil-decreases-mucus-production-and-the-inflammatory-response-in-mice-with-ovalbumin-induced-allergic-lung-inflammation
#10
Jean A Hall, Jaye Hartman, Monica M Skinner, Adam R Schwindt, Kay A Fischer, William R Vorachek, Gerd Bobe, Beth A Valentine
The prevalence of asthma has increased in recent decades, which may be related to higher dietary intake of (n-6) polyunsaturated fatty acids (PUFA) and lower intake of (n-3) PUFA, e.g., those contained in fish oil. The objective of this study was to determine if dietary PUFA enrichment decreases mucus production or the inflammatory response associated with ovalbumin (OVA)-induced allergic lung inflammation. Mice (n = 10/group) were fed control, 20% fish oil, or 20% corn oil enriched diets for a total of 12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27650303/the-impact-of-high-density-lipoprotein-on-oxidant-antioxidant-balance-in-healthy-elderly-subjects
#11
Sylwia Dzięgielewska-Gęsiak, Lena Bielawska, Miłosława Zowczak-Drabarczyk, Karolina Hoffmann, Maciej Cymerys, Małgorzata Muc-Wierzgoń, Ewa Wysocka, Wiesław Bryl
INTRODUCTION    There is an inverse relationship between high density lipoprotein cholesterol concentration and risk of atherosclerosis.  OBJECTIVES    The aim of the study was to assess an oxidant-antioxidant balance in elderly subjects with different concentrations of high density lipoprotein cholesterol. PATIENTS AND METHODS    541 elderly persons ≥ 60 years were investigated. 90 of them, with no acute or severe chronic disorder were assessed:  waist circumference (WC), body mass index (BMI), percentage of body fat (FAT) and blood pressure...
September 20, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27650261/expression-of-dermcidin-in-human-sinonasal-secretions
#12
Elizabeth E Cottrill, Bei Chen, Nithin D Adappa, James N Palmer, David W Kennedy, Robert J Lee, Noam A Cohen
BACKGROUND: Antimicrobial peptides (AMPs) produced by the epithelium are important for innate immune defense. In 2001, a novel AMP dermcidin (DCD) was described with no homology to other AMPs and an expression pattern restricted to eccrine sweat glands. In contrast to other AMPs, DCD expression has not been shown to be induced under inflammatory conditions in the skin. After identifying DCD by mass spectrometry in a protein sample isolated from human nasal secretions, we sought to determine the role of DCD in innate defense of the sinonasal airway...
September 21, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27645929/astragalus-polysaccharide-modulates-er-stress-response-in-an-ova-lps-induced-murine-model-of-severe-asthma
#13
Yuan Lu, Qiong-Qiong Xing, Jian-Ya Xu, Dou Ding, Xia Zhao
Endoplasmic reticulum (ER) stress has been recently revealed to play a pivotal role in the pathogenesis of severe asthma. Astragalus polysaccharide (APS), a major bioactive component from Astragalus membranaceus, exerts immunomodulatory and anti-inflammatory effects and has been shown to suppress ER stress in chronic diseases such as type-2 diabetes. However, the pharmaceutical application of APS in the treatment of severe asthma is unknown. The results obtained here indicate that APS significantly attenuates eosinophils and neutrophil-dominant airway inflammation by reducing the mRNA levels of Cxcl5, Il8, and chemokine (C-C motif) ligand 20 (Ccl20) and the protein levels of IL13RA and IL17RA...
September 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27636857/nutritional-characteristics-and-quality-of-eggs-from-laying-hens-fed-on-a-diet-supplemented-with-chestnut-tannin-extract-castanea-sativa-miller
#14
S Minieri, A Buccioni, A Serra, I Galigani, A Pezzati, S Rapaccini, M Antongiovanni
The trial was performed with 80 laying hens belonging to two Tuscan autochthonous breeds: 40 birds of the Mugellese breed (MU) and 40 of the White Leghorn breed (WL). The animals were allotted to 4 groups of 20 hens each: two groups were fed on a commercial diet and worked as the control groups (MUC and WLC); the other two groups received the same diet, integrated with 2 g of chestnut tannin extract per kg of diet (MUT and WLT). A sample of 70 eggs were randomly collected and analysed for cholesterol content, fatty acid profile, weight, thickness of shell and colour of yolk...
September 16, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27604757/expression-profiles-of-toll-like-receptors-in-the-differentiation-of-an-infection-with-borrelia-burgdorferi-sensu-lato-spirochetes
#15
Slawomir Dudek, Ewa Ziółko, Magdalena Kimsa-Dudek, Krzysztof Solarz, Urszula Mazurek, Aleksander Wierzgoń, Teresa Kokot, Małgorzata Muc-Wierzgoń
The similarity of Lyme borreliosis to other diseases and its complex pathogenesis present diagnostic and therapeutic difficulties. The changes that occur at the cellular and molecular levels after a Borrelia sp. infection still remain poorly understood. Therefore, the present study focused on the expression of TLR and TLR-signaling genes in human dermal fibroblasts in the differentiation of an infection with Borrelia burgdorferi sensu lato spirochetes. Normal human dermal fibroblasts were cultured with the spirochetes of Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii...
September 7, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27594562/endothelins-and-carcinogenesis
#16
Jacek Olender, Ewa Nowakowska-Zajdel, Katarzyna Walkiewicz, Małgorzata Muc-Wierzgoń
Endothelins are a family of four endogenous peptides (ET-1, ET-2, ET-3, ET-4) secreted primarily in an inactive form by the endothelium. They are activated with the participation of converting enzyme. Numerous studies have described their pleiotropic biological activity. These peptides are involved, inter alia, in the regulation of processes such as cell proliferation, migration, angiogenesis and apoptosis. Their important role in the regulation of blood pressure, tissue perfusion (especially in the central nervous system), and myocardial systolic function is also known...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27591765/distinct-pathways-of-pathogenesis-of-intraductal-oncocytic-papillary-neoplasms-and-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#17
Olca Basturk, Sun M Chung, Ralph H Hruban, N Volkan Adsay, Gokce Askan, Christine Iacobuzio-Donahue, Serdar Balci, Sui Y Zee, Bahar Memis, Jinru Shia, David S Klimstra
Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is classified as a variant of intraductal papillary mucinous neoplasm (IPMN) in the WHO guidelines. However, the neoplastic cells of IOPNs are unique, with distinctive architecture/oncocytic cytoplasm. Although molecular/immunohistochemical features of other IPMN variants have been extensively studied, those of IOPNs have not been well characterized. Expression profile of antibodies associated with genetic alterations previously described for ductal adenocarcinomas (DAs) and IPMNs (SMAD4/β-catenin/p53/mesothelin/claudin-4) as well as antibodies to mucins and differentiation markers [MUC1/MUC2/MUC5AC/MUC6/CDX2/hepatocyte paraffin-1 (HepPar-1)] was investigated in 24 IOPNs and 22 IPMNs to assess the similarities/differences between these tumors...
November 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27577176/the-lactase-13910c-t-polymorphism-rs4988235-is-associated-with-overweight-obesity-and-obesity-related-variables-in-a-population-sample-of-portuguese-young-adults
#18
L Manco, H Dias, M Muc, C Padez
BACKGROUND/OBJECTIVES: Several studies reported associations of the lactase gene (LCT) polymorphism -13910C>T (rs4988235) with obesity-related variables and obesity in adults. This study aimed to replicate previously reported associations in a population sample of Portuguese young adults. SUBJECTS/METHODS: We genotyped 447 subjects from central and northern regions of Portugal (mean age 20.81±4.24 years) for the lactase variant -13910C>T (rs4988235), using TaqMan probes...
August 31, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27569189/correlation-between-mucin-biology-and-tumor-heterogeneity-in-lung-cancer
#19
Menglin Xu, Diane C Wang, Xiangdong Wang, Yong Zhang
Mucins (MUC) are a family consisting of large O-glycoproteins whose primary functions are to protect and lubricate cell epithelial surfaces and contribute to intra- and inter-cellular signal pathways, cell proliferation, growth and apotosis. With the development of new technologies, MUCs begin to be identified as an effective marker in evaluating the tumor heterogeneity in lung cancer. MUCs' diverse expressions in subtypes of lung cancer indicate the inter-tumor heterogeneity. MUCs' mutation may also contribute to the development of intra-heterogeneity and evolution of lung cancer...
August 25, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27563024/muc-expression-in-gallbladder-epithelial-tissues-in-cholesterol-associated-gallbladder-disease
#20
Kyo-Sang Yoo, Ho Soon Choi, Dae Won Jun, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Kyeong Geun Lee, Seung Sam Paik, Yong Seok Kim, Jin Lee
BACKGROUND/AIMS: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterol-associated gallbladder disease and evaluated the relationship between mucin and bacterial infection. METHODS: The present study involved 20 patients with cholesterol stones with cholecystitis, five with cholesterol stones with cholesterolosis, six with cholesterol polyps, two with gallbladder cancer, and six controls...
September 15, 2016: Gut and Liver
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