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https://www.readbyqxmd.com/read/28107977/ultrasensitive-detection-of-mucin-1-biomarker-by-immuno-loop-mediated-isothermal-amplification
#1
Hongmei Cao, Xueen Fang, Haipeng Li, Hua Li, Jilie Kong
Mucin 1 (MUC-1), a glycoprotein over-expressed on most malignant epithelial cell surfaces, such as colorectal, lung, prostate, pancreatic, ovarian, and bladder carcinomas, has been confirmed as a useful biomarker for the diagnosis of early cancers. Therefore, it is very important for early cancer diagnoses to develop the sensitive and specific detection approach of MUC-1. In this paper, we report a novel technique of aptamer-based Immuno-Loop-Mediated Isothermal Amplification (Im-LAMP) for the quantitative detection of MUC-1 by MUC-1 aptamer with high affinity for MUC-1...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28106268/innate-immune-defense-in-the-inner-ear-mucines-are-expressed-by-the-human-endolymphatic-sac
#2
Martin N Møller, Svend Kirkeby, Per Cayé-Thomasen
The human endolymphatic sac has been shown recently to have immunological capacities and has thus been proposed as the main entity protecting the inner ear from pathogen invasion, equivalent to mucosa-associated lymphoid tissue (MALT). Although the sac expresses molecules of the innate immune system, the potential expression of members of the important mucin family has not been detailed. Thus, this paper explores endolymphatic sac expression of a number of mucins and mucin precursors. Twelve fresh tissue samples from the human endolymphatic sac were obtained during translabyrinthine surgery...
February 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28095754/3d-co-culture-of-meniscal-cells-and-mesenchymal-stem-cells-in-collagen-type-i-hydrogel-on-a-small-intestinal-matrix-a-pilot-study-towards-equine-meniscus-tissue-engineering
#3
Antje Kremer, Iris Ribitsch, Jenny Reboredo, Julia Dürr, Monika Egerbacher, Florien Jenner, Heike Walles
Meniscal injuries are the most frequently encountered soft tissue injuries in the equine stifle joint. Due to the inherent limited repair potential of meniscal tissue, meniscal injuries do not only affect the meniscus itself but also lead to impaired joint homeostasis and secondary osteoarthritis. The presented study compares 3D co-culture constructs of primary equine mesenchymal stem cells (MSC) and meniscus cells (MC) seeded on three different scaffolds - a cell-laden collagen type I hydrogel (Col I gel), a tissue-derived small intestinal matrix scaffold (SIS-muc) and a combination thereof - for their qualification to be applied for meniscus tissue engineering...
January 18, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28088838/re-evaluation-of-phenotypic-expression-in-differentiated-type-early-adenocarcinoma-of-the-stomach
#4
Masato Hayakawa, Ken Nishikura, Yoichi Ajioka, Yutaka Aoyagi, Shuji Terai
A total of 313 cases of differentiated-type early gastric adenocarcinomas, including 113 cases of small-sized carcinoma (5< × ≤10 mm) and 121 cases of microcarcinoma (0< × ≤5 mm), were examined immunohistochemically to clarify the phenotypic expressions. They were classified into four categories (gastric phenotype (G-type), intestinal phenotype, gastrointestinal phenotype, and null phenotype) by a two-step process: the phenotype based on an immunoprofile of mucin core proteins (MUCs) with CDX2 (w/...
January 15, 2017: Pathology International
https://www.readbyqxmd.com/read/28057747/complete-genome-sequence-of-akkermansia-glycaniphila-strain-pytt-a-mucin-degrading-specialist-of-the-reticulated-python-gut
#5
Janneke P Ouwerkerk, Jasper J Koehorst, Peter J Schaap, Jarmo Ritari, Lars Paulin, Clara Belzer, Willem M de Vos
Akkermansia glycaniphila is a novel Akkermansia species that was isolated from the intestine of the reticulated python and shares the capacity to degrade mucin with the human strain Akkermansia muciniphila Muc(T) Here, we report the complete genome sequence of strain Pyt(T) of 3,074,121 bp. The genomic analysis reveals genes for mucin degradation and aerobic respiration.
January 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28053814/a-concurrence-of-adenocarcinoma-with-micropapillary-features-and-composite-glandular-endocrine-cell-carcinoma-in-the-stomach
#6
Ji-Hoon Kim, Dae-Woon Eom, Cheon-Soo Park, Jae-Young Kwak, Eun-Hwa Park, Jin-Ho Kwak, Hyuk-Jae Jang, Kun-Moo Choi, Myung-Sik Han
We report a unique case of synchronous double primary gastric cancer consisting of adenocarcinoma components with micropapillary features and composite glandular-endocrine cell carcinoma components. The patient was a 53-year-old man presenting with a 6-month history of epigastric pain and diarrhea. A subtotal gastrectomy was performed. Histologically, one tumor was composed of micropapillary carcinoma components (50%) with tight clusters of micropapillary aggregates lying in the empty spaces, admixed with moderately differentiated adenocarcinoma components...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28045589/dietary-selenium-protects-adiponectin-knockout-mice-against-chronic-inflammation-induced-colon-cancer
#7
Arpit Saxena, Raja Fayad, Kamaljeet Kaur, Samantha Truman, Julian Greer, James A Carson, Anindya Chanda
Selenium (Se) is an essential dietary micronutrient that has been examined for protection against different types of cancers including colon cancer. Despite an established inverse association between Se and chronic inflammation induced colon cancer (CICC), the mechanistic understanding of Se's protective effects requires additional in-vivo studies using preclinical animal models of CICC. Adiponectin (APN) is an adipocytokine that is protective against CICC as well. However, its role in the anti-mutagenic effects of the Se-diet remains unknown...
January 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28040470/establishment-and-characterization-of-an-in-vitro-human-small-airway-model-smallair%C3%A2
#8
Song Huang, Bernadett Boda, Jimmy Vernaz, Emilie Ferreira, Ludovic Wiszniewski, Samuel Constant
We report here the establishment and characterization of an in vitro human small airway model (SmallAir™). The epithelial cells were isolated from the distal lungs by enzymatic digestion. After amplification, the cells were seeded on the microporous membrane of Transwell inserts. Once confluent, the cultures were switched to air-liquid interface. After 3 weeks of culture, the epithelium became fully differentiated, with morphology of columnar epithelium, and a thickness of 10-15 μm. Most significantly, CC-10, a specific marker of Club cells, was highly expressed in SmallAir™...
December 28, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28002540/gallbladder-carcinoma-a-rare-cause-of-pyloric-duodenal-stenosis
#9
Zizi Niculescu, Victoria Ulmeanu, Mihaela Maria Ghinea, Liliana Mocanu, Costin Niculescu, Mircea Grigorian
Pyloric duodenal stenosis is usually caused by pyloric, juxtapyloric or duodenal ulcer, or by postbulbar ulcer. Gallbladder cancer (GBC), duodenal diverticula, annular pancreas and superior mesenteric artery syndrome (Wilkie's syndrome) are rare causes of pyloric duodenal stenosis. The case of a 66-year-old female patient is presented. The patient was admitted to hospital presenting anorexia, repeated alimentary vomiting, epigastric pain, and weight loss. Objective clinical examination upon admission: clapotage à jeun is present, triggered by tapping the epigastric region...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27981577/the-clinical-pharmacokinetics-and-pharmacodynamics-of-atezolizumab-in-metastatic-urothelial-carcinoma
#10
Mark Stroh, Helen Winter, Mathilde Marchand, Laurent Claret, Steve Eppler, Jane Ruppel, Oyewale Abidoye, Siew Leng Teng, Wan-Ting Lin, Sheila Dayog, Rene Bruno, Jin Jin, Sandhya Girish
Atezolizumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting human programmed death-ligand 1, is FDA-approved in metastatic urothelial carcinoma (mUC) and is being investigated in various malignancies. This analysis, based upon 906 patients from two Phase I and one Phase II mUC studies, is the first report of the clinical pharmacokinetics and pharmacodynamics of atezolizumab. Atezolizumab exhibited linear pharmacokinetics over a dose range of 1 - 20 mg/kg, including the labeled 1200 mg dose...
December 16, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27975160/glycosylation-a-hallmark-of-cancer
#11
REVIEW
Bhairavi N Vajaria, Prabhudas S Patel
The hallmarks of cancer are characterized by functional capabilities that allow cancer cells to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a cellular disease, changes in cellular glycoproteins play an important role in malignant transformation and cancer progression. The present review summarizes various studies that depicted correlation of glycosylation with tumor initiation, progression and metastasis, which are helpful in early diagnosis, disease monitoring and prognosis...
December 14, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27964892/prognostic-value-of-baseline-neutrophil-to-lymphocyte-ratio-in-metastatic-urothelial-carcinoma-patients-treated-with-first-line-chemotherapy-a-large-multicenter%C3%A2-study
#12
Marie Auvray, Reza Elaidi, Mustafa Ozguroglu, Sermin Guven, Hélène Gauthier, Stéphane Culine, Armelle Caty, Charlotte Dujardin, Edouard Auclin, Constance Thibaut, Pierre Combe, Eric Tartour, Stéphane Oudard
BACKGROUND: A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and is associated with poor survival in localized or metastatic cancer. This study assessed the prognostic value of NLR after first-line chemotherapy (CT) in patients with metastatic urothelial carcinoma (mUC). PATIENTS AND METHODS: Two hundred eighty consecutive patients treated with first-line platinum-based CT at 4 centers in France and Turkey between 2002 and 2014 were included...
November 16, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27924608/a-method-to-isolate-purify-and-characterize-human-periodontal-ligament-stem-cells
#13
Krzysztof Mrozik, Stan Gronthos, Songtao Shi, P Mark Bartold
Human periodontal ligament stem cells (PDLSCs) are a unique population of mesenchymal stem cells (MSCs) that demonstrate the capacity to generate cementum- and periodontal ligament-like structures in vivo. As such, PDLSCs represent a promising cell-based therapy in reconstructive dentistry for the treatment of periodontal disease. The present chapter describes two methods for isolating PDLSCs from human PDL tissue including traditional plastic adherence, and immunomagnetic selection based on the expression of MSC-associated surface markers STRO-1 antigen, CD146 (MUC-18), CD29 (Integrin β-1), CD44, and CD106 (VCAM-1)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27923652/mir-211-inhibits-invasion-and-epithelial-to-mesenchymal-transition-emt-of-cervical-cancer-cells-via-targeting-muc4
#14
Dongkui Xu, Shikai Liu, Liang Zhang, Lili Song
The dysregulated molecules and their involvement in lymph node metastases of cervical cancer are far from been fully revealed. In this study, by reviewing MUC4 expression in The Human Protein Atlas and retrieving gene microarray data in GEO dataset (No. GDS4664), we found that MUC4 upregulation is associated with lymph node metastasis in cervical cancer. Knockdown of MUC4 in Hela and SiHa cells significantly reduced their invasion and also reduced the mesenchymal properties. By performing bioinformatics analysis, we observed that miR-211 is a potential suppressor of MUC4, which has a predicted highly conserved binding site in the 3'UTR of MUC among mammals...
December 3, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27893426/sublethal-exposure-to-alpha-radiation-223ra-dichloride-enhances-various-carcinomas-sensitivity-to-lysis-by-antigen-specific-cytotoxic-t-lymphocytes-through-calreticulin-mediated-immunogenic-modulation
#15
Anthony S Malamas, Sofia R Gameiro, Karin M Knudson, James W Hodge
Radium-223 dichloride (Xofigo®; 223Ra) is an alpha-emitting radiopharmaceutical FDA-approved for the treatment of bone metastases in patients with advanced castration-resistant prostate cancer. It is also being examined clinically in patients with breast and lung carcinoma and patients with multiple myeloma. As with other forms of radiation, the aim of 223Ra is to reduce tumor burden by directly killing tumor cells. External beam (photon) and proton radiation have been shown to augment tumor sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes (CTLs)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890438/short-term-clinical-results-of-frozen-shoulder-treated-with-shoulder-manipulation-under-ultrasound-guided-cervical-nerve-root-block-at-outpatient-setting-a-case-series
#16
Tomohiro Saito, Hideyuki Sasanuma, Yuki Iijima, Yuji Kanaya, Toshihiro Saito, Hideaki Watanabe, Ichiro Kikkawa, Katsushi Takeshita
BACKGROUND: We evaluated the short-term clinical outcomes of frozen shoulder treatment via shoulder manipulation under ultrasound-guided cervical nerve root block (MUC). METHODS: This study included frozen shoulder patients who were unresponsive to conservative therapy for at least 6 months and were then treated with MUC. Patients with a rotator cuff tear, calcifying tendinitis, osteoarthritis, or any other shoulder disorder were excluded following X-ray, ultrasound, and magnetic resonance imaging evaluation...
November 25, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27795812/mucins-in-neoplasms-of-pancreas-ampulla-of-vater-and-biliary-system
#17
REVIEW
Dimitrios Moschovis, Giorgos Bamias, Ioanna Delladetsima
Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN)...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27778475/abstracts-of-the-25th-malaysian-urological-conference-muc-2016-malaysia-25-november-2016
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2016: BJU International
https://www.readbyqxmd.com/read/27764813/targeting-heterogeneity-of-adrenocortical-carcinoma-evaluation-and-extension-of-preclinical-tumor-models-to-improve-clinical-translation
#19
Constanze Hantel, Igor Shapiro, Giada Poli, Costanza Chiapponi, Martin Bidlingmaier, Martin Reincke, Michaela Luconi, Sara Jung, Felix Beuschlein
In recent years it has been recognized that clinical translation of novel therapeutic strategies for patients with adrenocortical carcinoma (ACC) often fails. These disappointing results indicate that the currently utilized tumor models only poorly reflect relevant pathophysiology and, thereby, do not predict clinical applicability of novel pharmacological approaches. However, also the development of new preclinical ACC models has remained a challenge with only one human cell line (NCI-H295R) and one recently established human pediatric xenograft model (SJ-ACC3) being available for this highly heterogeneous malignancy...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733047/paradox-ca-15-3-increase-in-metastatic-breast-cancer-patients-treated-with-everolimus-a-change-of-paradigm-in-a-case-series
#20
Armando Orlandi, Carmela Di Dio, Maria Alessandra Calegari, Carlo Barone
Everolimus and exemestane represent a standard treatment for metastatic hormone receptor-positive/HER2-negative advanced breast cancer resistant to aromatase inhibitors. CA 15-3 serum levels detect soluble forms of MUC-1, a transmembrane oncoprotein aberrantly overexpressed in breast cancers. In clinical practice, CA 15-3 may be used to indicate treatment failure in the absence of readily measurable disease during cytotoxic therapy. In the targeted therapy era, it is important to note that the C-terminal subunit of MUC-1 interacts with PI3K/AKT pathway, inducting cell growth...
October 13, 2016: Biomarkers in Medicine
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