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Antibiotic catheter locks

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https://www.readbyqxmd.com/read/27872830/bacteremia-in-hemodialysis-patients
#1
REVIEW
Masashi Suzuki, Nobuhiko Satoh, Motonobu Nakamura, Shoko Horita, George Seki, Kyoji Moriya
Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27788992/catheter-related-infections-in-patients-with-haematological-malignancies-novel-preventive-and-therapeutic-strategies
#2
REVIEW
Ramia Zakhour, Anne-Marie Chaftari, Issam I Raad
Central venous catheters are essential for the treatment of patients with haematological malignancies and the recipients of stem-cell transplant. This patient population is, however, at high risk for catheter-related bloodstream infections that can result in substantial morbidity, mortality, and health-care-associated costs. Efficient prevention, early diagnosis, and effective treatment are essential to providing the best care to these patients. Although confirming the catheter as a source of infection remains challenging, the Infectious Diseases Society of America definition of catheter-related bloodstream infection remains the most precise definition to use in these patients...
November 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27730778/antibiotic-lock-therapy-in-the-era-of-gram-negative-resistance
#3
Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27595511/serratia-marcescens-bacteraemia-outbreak-in-haemodialysis-patients-with-tunnelled-catheters-due-to-colonisation-of-antiseptic-solution-experience-at-4-hospitals
#4
José L Merino, Hanane Bouarich, Mª José Pita, Patricia Martínez, Blanca Bueno, Silvia Caldés, Elena Corchete, Mª Teresa Jaldo, Beatriz Espejo, Vicente Paraíso
INTRODUCTION: The application of antiseptic solution for handling tunnelled catheters is recommended in patients undergoing haemodialysis. These routine antiseptic procedures in handling catheters are crucial to avoid complications. We report an outbreak of Serratia marcescens (S. marcescens) bacteraemia in numerous haemodialysis units of the Community of Madrid. MATERIAL AND METHODS: The first cases of bacteraemia due to S. marcescens were isolated in December 2014...
November 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27524227/antibiotic-lock-therapy-for-leuconostoc-pseudomesenteroides-catheter-related-bacteremia
#5
Jackie Ho, Jeffrey C Jolliff, Arash Heidari
No abstract text is available yet for this article.
August 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27516141/evidence-based-criteria-for-the-choice-and-the-clinical-use-of-the-most-appropriate-lock-solutions-for-central-venous-catheters-excluding-dialysis-catheters-a-gavecelt-consensus
#6
Mauro Pittiruti, Sergio Bertoglio, Giancarlo Scoppettuolo, Roberto Biffi, Massimo Lamperti, Alberto Dal Molin, Nicola Panocchia, Nicola Petrosillo, Mario Venditti, Carla Rigo, Enrico DeLutio
BACKGROUND: The most appropriate lock solution for central venous access devices is still to be defined. GAVeCeLT - the Italian group for venous access devices - has developed a consensus on the evidence-based criteria for the choice and the clinical use of the most appropriate lock solution for central venous catheters (excluding dialysis catheters). METHOD: After the constitution of a panel of experts, a systematic collection and review of the literature has been performed, focusing on clinical studies dealing with lock solutions used for prevention of occlusion (heparin, citrate, urokinase, recombinant tissue plasminogen activator [r-TPA], normal saline) or for prevention of infection (citrate, ethanol, taurolidine, ethylene-diamine-tetra-acetic acid [EDTA], vancomycin, linezolid and other antibiotics), in both adults and in pediatric patients...
August 1, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27458213/eradication-of-staphylococcus-aureus-catheter-related-biofilm-infections-using-ml-8-and-citrox
#7
S Hogan, M Zapotoczna, N T Stevens, H Humphreys, J P O'Gara, E O'Neill
Staphylococci are a leading cause of catheter-related infections (CRIs) due to biofilm formation. CRIs are typically managed by either device removal or systemic antibiotics, often in combination with catheter lock solutions (CLSs). CLSs provide high concentrations of the antimicrobial agent at the site of infection. However, the most effective CLSs against staphylococcal biofilm-associated infections have yet to be determined. The purpose of this study was to evaluate the efficacy and suitability of two newly described antimicrobial agents, ML:8 and Citrox, as CLSs against Staphylococcus aureus biofilms...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27390716/is-taurolidine-citrate-an-effective-and-cost-effective-hemodialysis-catheter-lock-solution-a-systematic-review-and-cost-effectiveness-analysis
#8
Zahra Kavosi, Maryam Sarikhani Khorrami, Khosro Keshavarz, Abdosaleh Jafari, Amir Hashemi Meshkini, Hamid Reza Safaei, Shekoufeh Nikfar
BACKGROUND: Prevention of catheter-related infection is of prime importance,. However, because of the risks caused by the leakage of circulating antibiotics and development of resistance to antibiotics, they are replaced by lock solutions. The aim of this study was to evaluate the efficacy and cost- effectiveness of taurolidine-citrate as a hemodialysis catheter lock solution compared to other common alternatives in Iran. METHODS: To evaluate the efficacy of taurolidine-citrate, a systematic review was conducted by searching electronic databases...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27297475/in-vitro-assessment-of-the-antimicrobial-efficacy-of-optimized-nitroglycerin-citrate-ethanol-as-a-nonantibiotic-antimicrobial-catheter-lock-solution-for-prevention-of-central-line-associated-bloodstream-infections
#9
Ruth A Reitzel, Joel Rosenblatt, Cheryl Hirsh-Ginsberg, Kimberly Murray, Anne-Marie Chaftari, Ray Hachem, Issam Raad
The rapid, broad-spectrum, biofilm-eradicating activity of the combination of 0.01% nitroglycerin, 7% citrate, and 20% ethanol and its potential as a nonantibiotic, antimicrobial catheter lock solution (ACLS) were previously reported. Here, a nitroglycerin-citrate-ethanol (NiCE) ACLS optimized for clinical assessment was developed by reducing the nitroglycerin and citrate concentrations and increasing the ethanol concentration. Biofilm-eradicating activity was sustained when the ethanol concentration was increased from 20 to 22% which fully compensated for reducing the citrate concentration from 7% to 4% as well as the nitroglycerin concentration from 0...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27234677/misuse-of-antibiotics-reserved-for-hospital-settings-in-outpatients-a-prospective-clinical-audit-in-a-university-hospital-in-southern-france
#10
Manon Roche, Charléric Bornet, Philippe Monges, Andreas Stein, Sophie Gensollen, Piseth Seng
Some antibiotics are reserved essentially for hospital settings owing to cost effectiveness and in order to fight the emerging antibiotic resistance crisis. In some cases, antibiotics reserved exclusively for use in hospitals may be prescribed in outpatients for serious infections or in the absence of a therapeutic alternative. A 30-day prospective audit of outpatient prescriptions of antibiotics reserved exclusively for use in hospitals was performed. The objective of this study was to evaluate the relevance of outpatient antibiotic prescriptions by measuring appropriateness according to guidelines...
July 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27152201/catheter-related-bloodstream-infection-in-end-stage-kidney-disease-a-canadian-narrative-review
#11
REVIEW
Chris Lata, Louis Girard, Michael Parkins, Matthew T James
PURPOSE OF THE REVIEW: Patients with end-stage renal disease (ESRD) are at a high risk of bacterial infection. We reviewed publications on risk factors, prevention, and treatment paradigms, as well as outcomes associated with bacterial infection in end-stage kidney disease. We focused in particular on studies conducted in Canada where rates of haemodialysis catheter use are high. SOURCES OF INFORMATION: We included original research articles in English text identified from MEDLINE using search terms 'chronic kidney failure', 'renal dialysis', or 'chronic renal insufficiency', and 'bacterial infection'...
2016: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/27067705/spontaneous-fracture-and-migration-of-catheter-of-a-totally-implantable-venous-access-port-via-internal-jugular-vein-a-case-report
#12
Seung Yeon Ko, Sun Cheol Park, Jeong Kye Hwang, Sang Dong Kim
BACKGROUND: The totally implantable venous access ports (TIVAPs) are indicated for patients undergoing chemotherapy, total parenteral nutrition and long-term antibiotic treatment. But, among their complications, the fracture and migration of the catheter of a TIVAP via internal jugular vein represents a very rare but potentially severe condition. CASE PRESENTATION: A 50-year-old woman indentified with a spontaneous fracture and migration of catheter of a TIVAP via right internal jugular vein after adjuvant chemotherapy for ovary cancer...
April 11, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27061792/we-avoid-antibiotic-lock-solutions-due-to-fear-of-antibiotic-resistance
#13
Namrata Krishnan
Hemodialysis catheter-related bacteremia (CRB) is the most common complication associated with catheter use in dialysis patients and portends a high morbidity and mortality. Current CDC and KDIGO guidelines recommend treating CRBs with systemic antibiotics in conjunction with catheter replacement, although the latter has limitations. Antibiotic lock solutions (ABLs) are very effective in both prevention and treatment of CRBs in hemodialysis patients and may be a preferred alternative to catheter replacement especially in patients where catheter salvage is a priority...
July 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27039404/anticoagulants-and-antiplatelet-agents-for-preventing-central-venous-haemodialysis-catheter-malfunction-in-patients-with-end-stage-kidney-disease
#14
REVIEW
Ying Wang, Jessica N Ivany, Vlado Perkovic, Martin P Gallagher, Mark Woodward, Meg J Jardine
BACKGROUND: Catheter malfunction, including thrombosis, is associated with reduced dialysis adequacy, as well as an increased risk of catheter-related bacteraemia and mortality. The role of anticoagulants in the prevention of catheter malfunction remains uncertain. OBJECTIVES: This review aimed to compare the prophylactic effect of different anticoagulant agents, preparations, doses and administration on the incidence of central venous haemodialysis catheter-related malfunction and sepsis in patients with end-stage kidney disease (ESKD)...
April 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27032770/central-venous-access-in-the-pediatric-population-with-emphasis-on-complications-and-prevention-strategies
#15
REVIEW
Lori A Duesing, Jason A Fawley, Amy J Wagner
Central venous catheters are often necessary in the pediatric population. Access may be challenging, and each vessel presents its own unique set of risks and complications. Central venous catheterization is useful for hemodynamic monitoring, rapid fluid infusion, and administration of hyperosmolar medications, including vasopressors, antibiotics, chemotherapy, and parenteral nutrition. Recent advances have improved the catheters used as well as techniques for insertion. A serious complication of central access is infection, which is associated with morbidity, mortality, and significant financial costs...
August 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27001822/successful-salvage-of-central-venous-catheters-in-patients-with-catheter-related-or-central-line-associated-bloodstream-infections-by-using-a-catheter-lock-solution-consisting-of-minocycline-edta-and-25-ethanol
#16
Issam Raad, Anne-Marie Chaftari, Ramia Zakhour, Mary Jordan, Zanaib Al Hamal, Ying Jiang, Ammar Yousif, Kumait Garoge, Victor Mulanovich, George M Viola, Soha Kanj, Egbert Pravinkumar, Joel Rosenblatt, Ray Hachem
In cancer patients with long-term central venous catheters (CVC), removal and reinsertion of a new CVC at a different site might be difficult because of the unavailability of accessible vascular sites. In vitro and animal studies showed that a minocycline-EDTA-ethanol (M-EDTA-EtOH) lock solution may eradicate microbial organisms in biofilms, hence enabling the treatment of central line-associated bloodstream infections (CLABSI) while retaining the catheter in situ Between April 2013 and July 2014, we enrolled 30 patients with CLABSI in a prospective study and compared them to a historical group of 60 patients with CLABSI who had their CVC removed and a new CVC inserted...
June 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26982376/catheter-impregnation-coating-or-bonding-for-reducing-central-venous-catheter-related-infections-in-adults
#17
REVIEW
Nai Ming Lai, Nathorn Chaiyakunapruk, Nai An Lai, Elizabeth O'Riordan, Wilson Shu Cheng Pau, Sanjay Saint
BACKGROUND: The central venous catheter (CVC) is essential in managing acutely ill patients in hospitals. Bloodstream infection is a major complication in patients with a CVC. Several infection control measures have been developed to reduce bloodstream infections, one of which is impregnation of CVCs with various forms of antimicrobials (either with an antiseptic or with antibiotics). This review was originally published in June 2013 and updated in 2016. OBJECTIVES: Our main objective was to assess the effectiveness of antimicrobial impregnation, coating or bonding on CVCs in reducing clinically-diagnosed sepsis, catheter-related blood stream infection (CRBSI), all-cause mortality, catheter colonization and other catheter-related infections in adult participants who required central venous catheterization, along with their safety and cost effectiveness where data were available...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26926633/in-vitro-approach-for-identification-of-the-most-effective-agents-for-antimicrobial-lock-therapy-in-the-treatment-of-intravascular-catheter-related-infections-caused-by-staphylococcus-aureus
#18
S Hogan, M Zapotoczna, N T Stevens, H Humphreys, J P O'Gara, E O'Neill
Infection of intravascular catheters by Staphylococcus aureus is a significant risk factor within the health care setting. To treat these infections and attempt salvage of an intravascular catheter, antimicrobial lock solutions (ALSs) are being increasingly used. However, the most effective ALSs against these biofilm-mediated infections have yet to be determined, and clinical practice varies greatly. The purpose of this study was to evaluate and compare the efficacies of antibiotics and antiseptics in current clinical use against biofilms produced by reference and clinical isolates of S...
May 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26875584/how-can-the-complications-of-central-vein-catheters-be-reduced-intraluminal-prophylaxis-and-management-of-catheter-infections-role-of-antibiotic-locks
#19
https://www.readbyqxmd.com/read/26649405/-comparison-of-tigecycline-and-vancomycin-activities-in-an-in-vitro-biofilm-model-generated-with-methicillin-resistant-staphylococcus-aureus
#20
COMPARATIVE STUDY
Halil Aslan, Nur Yapar
Today, the most common cause of bloodstream infections, which led to high mortality, prolonged hospitalization and increased costs are the intravenous catheters. Among the microorganisms associated with catheter infections, staphylococci took the first place and because of their biofilm-forming properties they cause serious problems in treatment and management of the patients. Although the drug of choice in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection is vancomycin, its effect on the bacterial biofilm is known to be low...
October 2015: Mikrobiyoloji Bülteni
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