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https://www.readbyqxmd.com/read/28921389/altered-structure-and-intrinsic-functional-connectivity-in-post-stroke-aphasia
#1
Mi Yang, Pu Yang, Yun-Shuang Fan, Jiao Li, Dezhong Yao, Wei Liao, Huafu Chen
Previous studies have demonstrated that alterations of gray matter exist in post-stroke aphasia (PSA) patients. However, so far, few studies combined structural alterations of gray matter volume (GMV) and intrinsic functional connectivity (iFC) imbalances of resting-state functional MRI to investigate the mechanism underlying PSA. The present study investigated specific regions with GMV abnormality in patients with PSA (n = 17) and age- and sex- matched healthy controls (HCs, n = 20) using voxel-based morphometry...
September 18, 2017: Brain Topography
https://www.readbyqxmd.com/read/28913167/ictal-conduction-aphasia-and-ictal-angular-gyrus-syndrome-as-rare-manifestations-of-epilepsy-the-importance-of-ictal-testing-during-video-eeg-monitoring
#2
Johann Philipp Zöllner, Anja Haag, Anke Hermsen, Sebastian Bauer, Friederike Stahl, Karina Wulf, Katja Menzler, Philipp S Reif, Marlies Wagner, Axel Pagenstecher, Ulrich Sure, Susanne Knake, Felix Rosenow, Adam Strzelczyk
The aim of these two case reports is to demonstrate that a predefined, structured, multimodal clinical bed-side testing during seizures in a long-term video-EEG monitoring setting facilitates diagnosis of complex neuropsychological syndromes. To the best of our knowledge, we present the first case of conduction aphasia as the sole ictal semiology, and a patient with focal seizures producing an angular gyrus syndrome in the speech dominant hemisphere. The relevance of diagnosing ictal aphasic and angular gyrus syndromes and localizing the symptomatogenic zone is discussed...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28899009/in-and-out-of-control-brain-mechanisms-linking-fluency-of-action-selection-to-self-agency-in-patients-with-schizophrenia
#3
Martin Voss, Valérian Chambon, Dorit Wenke, Simone Kühn, Patrick Haggard
Sense of agency refers to the feeling of control over one's actions, and their consequences. It involves both predictive processes linked to action control, and retrospective 'sense-making' causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients' sense of agency remain unclear. We introduce a new 'prospective' aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28895445/strategic-infarct-location-for-post-stroke-cognitive-impairment-a-multivariate-lesion-symptom-mapping-study
#4
Lei Zhao, J Matthijs Biesbroek, Lin Shi, Wenyan Liu, Hugo J Kuijf, Winnie Wc Chu, Jill M Abrigo, Ryan Kl Lee, Thomas Wh Leung, Alexander Yl Lau, Geert J Biessels, Vincent Mok, Adrian Wong
Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28871031/angular-gyrus-involvement-at-encoding-and-retrieval-is-associated-with-durable-but-less-specific-memories
#5
Marieke van der Linden, Ruud M W J Berkers, Richard G M Morris, Guillén Fernández
After consolidation, information belonging to a mental schema is better remembered, but such memory can be less specific when it comes to details. A neuronal mechanism in line with this behavioral pattern could result from a dynamic interaction that entails mediation by a specific cortical network with associated hippocampal disengagement. We now report that in male and female adult human subjects, encoding and later consolidation of a series of objects embedded in a semantic schema was associated with a build-up of activity in the angular gyrus (AG) that predicted memory 24h later...
September 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28869474/cortical-metabolic-and-cognitive-correlates-of-disorientation-in-alzheimer-s-disease
#6
Gali H Weissberger, Rebecca J Melrose, Candace M Fanale, Joseph V Veliz, David L Sultzer
Orientation to time, date, and place is commonly utilized in clinical settings to aid in diagnosis, staging, and monitoring of Alzheimer's disease (AD). This study aimed to identify the cerebral metabolic correlates of orientation in patients with AD, and the degree to which regions associated with orientation overlap with memory-related structures. Eighty-five patients with a diagnosis of probable AD underwent fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological testing. Orientation items from the Dementia Rating Scale and recognition performance from the Consortium to Establish a Registry for AD (CERAD) Word List Learning test were correlated with cerebral glucose metabolism...
September 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28865283/the-supramarginal-and-angular-gyri-underlie-orthographic-competence-in-spanish-language
#7
Andrés Antonio González-Garrido, Fernando Alejandro Barrios, Fabiola Reveca Gómez-Velázquez, Daniel Zarabozo-Hurtado
Orthographic competence allows automatic word recognition and reading fluency. To elucidate how the orthographic competence in Spanish-speaking adults might affect the neurofunctional mechanisms of visual word recognition, 32 young adults equally divided in two groups (HSS: High Spelling Skills, and LSS: Low Spelling Skills) were evaluated using fMRI methods, while they performed an orthographic recognition task involving pseudohomophones. HSS achieved significantly more correct responses and lower reaction times than LSS...
August 30, 2017: Brain and Language
https://www.readbyqxmd.com/read/28861001/increased-gray-matter-volume-and-resting-state-functional-connectivity-in-somatosensory-cortex-and-their-relationship-with-autistic-symptoms-in-young-boys-with-autism-spectrum-disorder
#8
Jia Wang, Kuang Fu, Lei Chen, Xujun Duan, Xiaonan Guo, Heng Chen, Qiong Wu, Wei Xia, Lijie Wu, Huafu Chen
Autism spectrum disorder (ASD) has been widely recognized as a complex neurodevelopmental disorder. A large number of neuroimaging studies suggest abnormalities in brain structure and function of patients with ASD, but there is still no consistent conclusion. We sought to investigate both of the structural and functional brain changes in 3-7-year-old children with ASD compared with typically developing controls (TDs), and to assess whether these alterations are associated with autistic behavioral symptoms. Firstly, we applied an optimized method of voxel-based morphometry (VBM) analysis on structural magnetic resonance imaging (sMRI) data to assess the differences of gray matter volume (GMV) between 31 autistic boys aged 3-7 and 31 age- and handness-matched male TDs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28856093/from-word-reading-to-multisentence-comprehension-improvements-in-brain-activity-in-children-with-autism-after-reading-intervention
#9
Donna L Murdaugh, Jose O Maximo, Claire E Cordes, Sarah E O'Kelley, Rajesh K Kana
BACKGROUND: Children with ASD show a unique reading profile characterized by decoding abilities equivalent to verbal abilities, but with lower comprehension skills. Neuroimaging studies have found recruitment of regions primarily associated with visual processing (e.g., fusiform gyrus and medial parietal cortex), but reduced activation in frontal and temporal regions, when reading in adults with ASD. The purpose of this study was to assess neural changes associated with an intense reading intervention program in children with ASD using three fMRI tasks of reading...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28846692/gyri-of-the-human-parietal-lobe-volumes-spatial-extents-automatic-labelling-and-probabilistic-atlases
#10
Heather M Wild, Rolf A Heckemann, Colin Studholme, Alexander Hammers
Accurately describing the anatomy of individual brains enables interlaboratory communication of functional and developmental studies and is crucial for possible surgical interventions. The human parietal lobe participates in multimodal sensory integration including language processing and also contains the primary somatosensory area. We describe detailed protocols to subdivide the parietal lobe, analyze morphological and volumetric characteristics, and create probabilistic atlases in MNI152 stereotaxic space...
2017: PloS One
https://www.readbyqxmd.com/read/28833690/changes-in-structure-and-perfusion-of-gray-matter-tissues-during-recovery-from-ischemic-subcortical-stroke-a-longitudinal-mri-study
#11
Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang
Stroke recovery with changes in volume and perfusion of gray matter (GM) tissues remains largely unknown. We hypothesized that GM atrophy co-existed with GM plasticity presenting with increased volume and perfusion in specific regions in the period of post-stroke recovery. Twelve well-recovered stroke patients with pure subcortical lesions in the middle cerebral artery-perfused zone were included. All of them underwent structural and perfusion MRI examinations at admission and a mean of 6-month after stroke onset...
August 22, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28813200/brain-microstructural-abnormalities-in-patients-with-cirrhosis-without-overt-hepatic-encephalopathy-a-voxel-based-diffusion-kurtosis-imaging-study
#12
Hua-Jun Chen, Peng-Fei Liu, Qiu-Feng Chen, Hai-Bin Shi
OBJECTIVE: This study aimed to investigate whole-brain microstructural abnormalities and their correlation with cognitive impairment in patients with cirrhosis using diffusion kurtosis imaging (DKI). SUBJECTS AND METHODS: Eighteen patients with cirrhosis and 17 healthy control subjects underwent DKI. Cognition was measured using psychometric hepatic encephalopathy (HE) scores. Whole-brain voxel-based analyses were performed to investigate between-group differences in DKI-derived parameters, including mean kurtosis, axial kurtosis, and radial kurtosis...
August 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28802988/does-education-play-a-role-in-language-reorganization-after-surgery-in-drug-refractory-temporal-lobe-epilepsy-an-fmri-based-study
#13
Kapil Chaudhary, Bhargavi Ramanujam, S Senthil Kumaran, P Sarat Chandra, Ashima Nehra Wadhawan, Ajay Garg, Manjari Tripathi
OBJECTIVES: Patients with drug refractory epilepsy (DRE) and a high level of education may differ in their language recovery after surgery. Our aim was to determine whether there were differences in the extent of improvement and pattern of reorganization of language functions on functional magnetic resonance imaging (fMRI) after surgery to treat refractory temporal lobe epilepsy (TLE) between patients with more than 12 years of formal education versus those with a shorter period of regular schooling...
October 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28802589/ventral-lateral-parietal-cortex-and-episodic-memory-retrieval
#14
REVIEW
Michael D Rugg, Danielle R King
With the advent of functional neuroimaging it quickly became apparent that successful episodic memory retrieval was consistently associated with enhanced activity in ventral lateral parietal cortex (VLPC), especially the left angular gyrus. Here, we selectively review recent neuropsychological and functional neuroimaging evidence relevant to the question of the functional significance of this activity. We argue that the balance of the evidence suggests that the angular gyrus supports the representation of retrieved episodic information, and that this likely reflects a more general role for the region in representing multi-modal and multi-domain information...
July 25, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28801254/the-effect-of-visual-parameters-on-neural-activation-during-nonsymbolic-number-comparison-and-its-relation-to-math-competency
#15
Eric D Wilkey, Jordan C Barone, Michèle M M Mazzocco, Stephan E Vogel, Gavin R Price
Nonsymbolic numerical comparison task performance (whereby a participant judges which of two groups of objects is numerically larger) is thought to index the efficiency of neural systems supporting numerical magnitude perception, and performance on such tasks has been related to individual differences in math competency. However, a growing body of research suggests task performance is heavily influenced by visual parameters of the stimuli (e.g. surface area and dot size of object sets) such that the correlation with math is driven by performance on trials in which number is incongruent with visual cues...
August 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28772125/discovering-event-structure-in-continuous-narrative-perception-and-memory
#16
Christopher Baldassano, Janice Chen, Asieh Zadbood, Jonathan W Pillow, Uri Hasson, Kenneth A Norman
During realistic, continuous perception, humans automatically segment experiences into discrete events. Using a novel model of cortical event dynamics, we investigate how cortical structures generate event representations during narrative perception and how these events are stored to and retrieved from memory. Our data-driven approach allows us to detect event boundaries as shifts between stable patterns of brain activity without relying on stimulus annotations and reveals a nested hierarchy from short events in sensory regions to long events in high-order areas (including angular gyrus and posterior medial cortex), which represent abstract, multimodal situation models...
August 2, 2017: Neuron
https://www.readbyqxmd.com/read/28746187/research-of-cerebral-activation-in-uygur-speaking-and-chinese-speaking-participants-during-verb-generation-task-with-functional-magnetic-resonance-imaging
#17
COMPARATIVE STUDY
Yanling Xi, Ling Liu, Grace Hao, Zulipinuer Abudusadike, Chunhui Jiang, Junran Zhang, Baolan Wang
The aims are to investigate and compare the activated cerebral regions of Uygur-speaking and Chinese-speaking participants during verb generation task.A total of 31 cases of Uygur and 28 cases of Han healthy volunteers were enrolled. They were requested to take verb generation tasks. Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) was performed. The fMRI images were collected and activated brain regions were analyzed.In Chinese-speaking participants, the main activated cerebral regions were as follows: the left caudate nucleus, the left occipital gyrus, the left fusiform gyrus, bilateral supplementary motor area (BA8/ 6), the left BA32, left precuneus, the left superior parietal lobule, the left inferior parietal lobule (BA7), the left angular gyrus, the right side of the central gyrus (BA9), the left inferior frontal gyrus triangular section, the right pars opercularis gyri frontalis inferiorista, and bilateral cerebellum...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28733357/a-role-for-the-left-angular-gyrus-in-episodic-simulation-and-memory
#18
Preston P Thakral, Kevin P Madore, Daniel L Schacter
Functional magnetic resonance imaging (fMRI) studies indicate that episodic simulation (i.e., imagining specific future experiences) and episodic memory (i.e., remembering specific past experiences) are associated with enhanced activity in a common set of neural regions referred to as the core network. This network comprises the hippocampus, medial prefrontal cortex, and left angular gyrus, among other regions. Because fMRI data are correlational, it is unknown whether activity increases in core network regions are critical for episodic simulation and episodic memory...
August 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#19
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730563/functional-connectivity-and-cognitive-impairment-in-migraine-with-and-without-aura
#20
Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
BACKGROUND: Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack. METHODS: Twenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited...
December 2017: Journal of Headache and Pain
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