Federico Lavorini, Celeste Barreto, Job F M van Boven, Will Carroll, Joy Conway, Richard W Costello, Birthe Hellqvist Dahl, Richard P N Dekhuijzen, Stephen Holmes, Mark Levy, Mathieu Molimard, Nicholas Roche, Miguel Román-Rodriguez, Nicola Scichilone, Jane Scullion, Omar S Usmani
Spacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding chambers (VHCs); they act as aerosol reservoirs, allowing the user to actuate the pMDI device and then inhale the medication in a 2-step process that helps users overcome challenges in coordinating pMDI actuation with inhalation. Both spacers and VHCs have been shown to increase fine particle delivery to the lungs, decrease oropharyngeal deposition, and reduce corticosteroid-related side effects such as throat irritation, dysphonia, and oral candidiasis commonly seen with the use of pMDIs alone...
May 2020: Journal of Allergy and Clinical Immunology in Practice