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Plasma Myeloma of the clavicle

Sanjay Kumar Mandal, Jacky Ganguly, Koelina Sil, Soumya Sarathi Mondal
A middle-aged male patient presented with fever, polyarthralgia, polyuria, easy fatigability and weight loss for 1 month. Clinically, there was only significant pallor and a swelling over the right sternoclavicular joint. On investigation, there was anaemia, raised urea, creatinine and pus cells in urine with growth of Escherichia coli. There were also hypercalcaemia and osteolytic lesions over the ribs, scapula, clavicle and skull along with distorted renal corticomedullary differentiation. Although the initial diagnosis was likely to be a case of multiple myeloma, serum protein electrophoresis was negative for the monoclonal band and no Bence-Jones protein was detected in urine...
March 6, 2014: BMJ Case Reports
Karla Gisela García-Álvarez, Roberto Garibaldi-Covarrubias, María Rosa Flores-Márquez, Carlos Ortiz-Hidalgo
Multiple myeloma is extremely rare in children and represents fewer than 1% of all patients with myeloma. We report a case of multiple myeloma in an 11-year-old girl, who presented with a well-differentiated immunoglobulin A/kappa plasmacytoma at the base of the skull at 9 years of age; at that time, the bone marrow biopsy was negative. Two years later, the patient experienced generalized bone pain with multiple lytic bone lesions that affected the skull, long bones, ribs, and clavicle. The bone marrow biopsy showed a well-differentiated (Marschalko-type) multiple myeloma that was positive for CD138 and immunoglobulin A, with kappa light chain restriction...
July 2012: Pediatric and Developmental Pathology
Garima Goel, Sharada Rai, Ramadas Naik, Astha Gupta, Poornima Baliga, Ruchi Sinha
OBJECTIVE: Extramedullary plasmacytoma (EMP) constitutes approximately 4% of all plasma cell neoplasms. It may present as the sole manifestation of plasma cell neoplasm, as a solitary plasmacytoma of the bone or as a consequence of multiple myeloma. This study was done to determine the role of fine needle aspiration cytology (FNAC) in the diagnosis of EMP. STUDY DESIGN: In our study 8 cases of EMP at various sites were diagnosed on FNAC. In 3 patients EMP was the initial presentation of plasma cell neoplasm...
May 2010: Acta Cytologica
Antonio Colonna, Gabriela Gualco, Carlos E Bacchi, Marcia Araujo Leite, Maurizio Rocco, Giovanna DeMaglio, Stefano Pizzolitto, Giovanni Falconieri
We described 2 cases of plasmacytoma presenting with a preponderant involvement of the pleural membranes simulating clinically, radiologically, and on gross pathologic inspection a primary mesothelioma. The patients were an 80-year-old man and a 45-year-old woman. In both cases, the clinical presentation was that of a serosal tumor, including effusions and pleural thickening. In the former, the serosal infiltration raised the suspicion of mesothelioma reinforced by history of occupational exposure to asbestos...
February 2010: Annals of Diagnostic Pathology
Airton Vieira-Leite-Segundo, Marcelo Ferreira Lima Falcão, Romualdo Correia-Lins Filho, Maria Sueli Marques Soares, José López López, Eduardo Chimenos Küstner
Multiple myeloma is a monoclonal malignant proliferation of plasma cells that causes osteolytic lesions in the vertebrae, ribs, pelvic bone, skull and jaw. We report on a clinical case of an 81-year-old male patient who presented with a tumefaction in the mandibular symphysis region, which had evolved over the previous seven months. In the radiographic examination, an extensive osteolytic lesion was observed in the region mentioned above. An incisional biopsy was performed and a histopathological study revealed a malignant hematopoietic neoplasm formed by plasmacytoid cells...
April 2008: Medicina Oral, Patología Oral y Cirugía Bucal
W A Shokunbi, A A Raji, E E Fakunle
BACKGROUND: Multiple myeloma (MM) is a clonalexpansion of plasma cell characterized by skeletal dissemination of malignant plasma cells resulting in the production of homogenous monoclonal immunoglobulin termed the monoclonal (M) protein. MM is the most prevalent cancer after non-Hodgkin's lymphoma and is responsible for 2% of all cancer deaths. Several unusual presentation of MM have been described in the literature. Many serial reports have documented progression of Plasmacytoma to MM, or relapsed into MM after radiation therapy...
October 2006: West African Journal of Medicine
T M Clough
This report describes a patient in whom sequential pathological fractures occurred at sites of plasma cell malignant bony deposits, but in which clinical and radiological healing occurred without treatment at the site of the initial deposit.
2001: Clinical Oncology: a Journal of the Royal College of Radiologists
I M Bakta, I N Sutarka
Monoclonal gammopathy is a group of B-cell disorders which result in the production of a specific and unique monoclonal immunoglobulin (M-component). Biclonal gammopathy is characterized by the simultaneous appearance of two different M-components. The incidence is about 1% of all monoclonal gammopathy. This paper reports on a 48-year-old male who had a chief complaint of back-pain beginning 7 months earlier. A physical examination was unremarkable, except for anemia and tenderness in the back. Hemoglobin was 5...
May 2000: Gan to Kagaku Ryoho. Cancer & Chemotherapy
F R Miller, P Lavertu, J R Wanamaker, J Bonafede, B G Wood
Plasmacytomas are rare tumors that often appear in the head and neck region and are characterized by a monoclonal proliferation of plasma cells. On both clinical presentation and pathologic examination these tumors may be confused with more common tumors of the head and neck. The purpose of this article is to review our experience with these rare neoplasms, with emphasis on clinical, pathologic, and therapeutic features. On retrospective chart review, we identified 20 patients with the diagnosis of plasmacytoma of the head and neck region at the Cleveland Clinic Foundation between 1976 and 1993...
December 1998: Otolaryngology—Head and Neck Surgery
T Miwa, Y Kimura, A Nonomura, M Kamide, M Furukawa
A rare case of extramedullary plasmacytoma in the sino-nasal cavity is presented. During a prolonged clinical course, the tumor has recurred several times after irradiation, chemotherapy and surgery, and presented in the clavicular bone as well. Immunohistochemical staining of each tumor showed IgA kappa phenotype, and immunoelectrophoresis of the serum showed overproduction of IgA with kappa light chains. Although an elevation of serum IgA persists, the patient has remained well without evidence of overt multiple myeloma...
1993: ORL; Journal for Oto-rhino-laryngology and its related Specialties
C Kruse, P Sander
An osseous plasmocytoma was masked by an excessive tumor-like deposit of amyloid to such an extent that the primary disease was only diagnosed after histological examination of autopsy material from a 62 year old woman. The 20 cm in diameter tumor originated from the manubrium sterni. Other tumors were found in the ribs, right clavicle, thoracic and lumbal spine and in the left femur. A massive layer of amyloid was found in these tumors by microscopy. Plasma cells infiltrated the area between the amyloid plaques and the macroscopically tumor-free vertebral bodies...
1987: Zentralblatt Für Allgemeine Pathologie und Pathologische Anatomie
D J Sartoris, D Pate, P Haghighi, G Greenway, D Resnick
We describe the clinical, radiographic, and pathologic manifestations of a group of disorders characterized by osteosclerosis in association with plasmacytic infiltration of bone marrow. These conditions include multiple myeloma, plasma cell granuloma, sternocostoclavicular hyperostosis, the POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes), and chronic symmetric plasma cell osteomyelitis of childhood. Although clinically unrelated in many respects, features shared by these diseases support the existence of a specific factor linking the plasma cell to local osteogenesis...
March 1986: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
G Mähr, G Breitfellner
The histological diagnosis of an apparently solitary destructive bone lesion revealed a plasmocytoma, being suspected of generalized spreading. Thereupon performed radiological examination demonstrated multiple radiolucent skeletal lesions and supported this diagnosis. Although specific hematological and proteinchemical findings were not indicative in the first instance, a second scrutiny of protein rates succeeded to demonstrate Bence-Jones-Kappa and consequently this case could be classified as a multiple micro-molecular plasmocytoma...
March 28, 1975: Medizinische Klinik
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