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https://www.readbyqxmd.com/read/29033593/expression-profiling-of-adhesion-proteins-during-prenatal-and-postnatal-liver-development-in-rats
#1
Mehwish Yousaf, Asima Tayyeb, Gibran Ali
Culturing of primary hepatocytes and stem cell-derived hepatocytes faces a major issue of dedifferentiation due to absence of cell-cell adhesion and 3D structures. One of the possible ways to eliminate the problem of dedifferentiation is mimicking the expression pattern of adhesion proteins during the normal developmental process of liver cells. The purpose of this study was to evaluate the expression pattern of some key adhesion proteins, namely, E-cadherin, N-cadherin, epithelial CAM (EpCAM), intracellular CAM (ICAM), collagen 1α1, α-actinin, β-catenin and vimentin, in the liver tissue during prenatal and postnatal stages...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/29030969/adropin-preserves-the-blood-brain-barrier-through-a-notch1-hes1-pathway-after-intracerebral-hemorrhage-in-mice
#2
Lingyan Yu, Zhengyang Lu, Sherrefa Burchell, Derek Nowrangi, Anatol Manaenko, Xue Li, Yang Xu, Ningbo Xu, Jiping Tang, Haibin Dai, John H Zhang
Adropin is expressed in the central nervous system (CNS) and plays a crucial role in the development of stroke. However, little is currently known about the effects of adropin on the blood-brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of adropin in collagenase-induced ICH was investigated in mice. At 1-h post ICH, mice were administered with recombinant human adropin by intranasal. Brain water content, BBB permeability, and neurological function were measured at different time intervals...
October 14, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29029500/edg2-enhanced-the-progression-of-hepatocellular-carcinoma-by-lpa-pi3k-akt-mtor-signaling
#3
Meng Xu, Zhikui Liu, Cong Wang, Bowen Yao, Xin Zheng
HCC is the leading type of the malignant liver tumors with the unsatisfied prognosis. Liver resection has been considered as the predominant curative therapy, however, the post-surgical prognostic evaluation remains an urgent problem and the mechanism of HCC metastases has not been understood completely. EDG2 has been found to accelerate tumor progression through mediating different cell pathways, however, it remains unclear about the role of EDG2 on hepatocarcinogenesis. Here, EDG2 expression was found increased notably in HCC tissues by immunohistochemistry compared with adjacent liver tissues and comparison of survival curves revealed that EDG2 upregulation in HCC tissues was associated with the worse prognosis after liver resection...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029446/a-potential-prognostic-biomarker-spc24-promotes-tumorigenesis-and-metastasis-in-lung-cancer
#4
Juan Zhou, Yang Yu, Yunfeng Pei, Chunping Cao, Chen Ding, Duping Wang, Li Sun, Guoping Niu
RESULTS: SPC24 is over-expressed in clinical lung adenocarcinoma samples, and high level of SPC24 is associated with advanced stages of lung tumors. Knocking down SPC24 repressed cell growth and promoted apoptosis. SPC24 deficiency reduced cancer cell migration as well. E-cadherin, one of the epithelial-mesenchymal transition markers, was up-regulated in the knockdown cells, along with down-regulation of N-cadherin and Vimentin. Oncomine expression analyses further confirmed that high level of SPC24 is associated with tumors from smokers, recurrent patients, or patients with shorter survivals...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029445/microrna-200c-increases-radiosensitivity-of-human-cancer-cells-with-activated-egfr-associated-signaling
#5
Taeryool Koo, Bong Jun Cho, Dan Hyo Kim, Ji Min Park, Eun Jung Choi, Hans H Kim, David J Lee, In Ah Kim
MicroRNA-200c (miR-200c) recently was found to have tumor-suppressive properties by inhibiting the epithelial-mesenchymal transition (EMT) in several cancers. miR-200c also interacts with various cellular signaling molecules and regulates many important signaling pathways. In this study, we investigated the radiosensitizing effect of miR-200c and its mechanism in a panel of human cancer cell lines. Malignant glioma (U251, T98G), breast cancer (MDA-MB-468), and lung carcinoma (A549) cells were transfected with control pre-microRNA, pre-miR-200c, or anti-miR-200c...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029437/long-non-coding-rna-ube2cp3-promotes-tumor-metastasis-by-inducing-epithelial-mesenchymal-transition-in-hepatocellular-carcinoma
#6
Shun-Wang Cao, Jin-Lan Huang, Jing Chen, Yan-Wei Hu, Xiu-Mei Hu, Ting-Yu Ren, Shi-Hao Zheng, Jin-Duan Lin, Jing Tang, Lei Zheng, Qian Wang
Hepatocellular carcinoma (HCC) is a highly aggressive, solid malignancy that has a poor prognosis. Long non-coding RNAs (lncRNAs) have been found to be dysregulated in various cancers, including HCC. However, the molecular mechanism involving lncRNAs in HCC remains largely unknown. In this study, lncRNAs differentially expressed between HCC and corresponding non-cancerous tissue were identified by microarray analysis. A specific differentially expressed lncRNA UBE2CP3 (ubiquitin conjugating enzyme E2 C pseudogene 3) was identified...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027485/concentration-dependent-effect-of-fumonisin-b1-on-apoptosis-in-oesophageal-cancer-cells
#7
R B Khan, A Phulukdaree, A A Chuturgoon
The geographical distribution of oesophageal cancer is linked to the exposure of fumonisin B1 (FB1), a mycotoxin produced by fungi that contaminates staple food worldwide. Non-genotoxic carcinogens like FB1 disturb homeostasis through increased cell proliferation or suppression of apoptosis. This study investigated the involvement of FB1 (0-20 μM) in spindle-shaped N-cadherin (+) CD45 (-) osteoblastic (SNO) cell death. Cell viability and death were assessed using the MTS and Annexin V-Fluos assays, respectively...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29027010/oxidized-regenerated-cellulose-induces-pleural-thickening-in-patients-with-pneumothorax-possible-involvement-of-the-mesothelial-mesenchymal-transition
#8
Hiroki Ebana, Takuo Hayashi, Keiko Mitani, Etsuko Kobayashi, Toshio Kumasaka, Teruaki Mizobuchi, Masatoshi Kurihara, Fumiyuki Takahashi, Kazuhisa Takahashi, Kuniaki Seyama
PURPOSE: The pleural covering technique, i.e., wrapping a part of or the entire surface of the lung with oxidized regenerative cellulose (ORC), reinforces visceral pleura through pleural thickening for patients with pneumothorax and cystic lung diseases. However, it remains undetermined how ORC induces pleural thickening. METHODS: A histopathological examination was performed for lung specimens from patients who had recurrent pneumothoraces after pleural covering and re-operation (n = 5)...
October 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29025375/dopamine-induced-sult1a3-4-promotes-emt-and-cancer-stemness-in-hepatocellular-carcinoma
#9
Juan Zou, Hong Li, Qianling Huang, Xiaomin Liu, Xiaoxiao Qi, Ying Wang, Linlin Lu, Zhongqiu Liu
Hepatocellular carcinoma has the second highest incidence rate among malignant cancers in China. Hepatocellular carcinoma development is complex because of the metabolism disequilibrium involving SULT1A3/4, a predominant sulfotransferase that metabolizes sulfonic xenobiotics and endogenous catecholamines. However, the correlation between SULT1A3/4 and hepatocellular carcinoma progression is unclear. By utilizing immunofluorescence and immunohistochemical analysis, we found that in nine hepatocellular carcinoma clinical specimens, SULT1A3/4 was abundantly expressed in tumor tissues compared to that in the adjacent tissues...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29025258/microrna-373-inhibits-cell-proliferation-and-invasion-via-targeting-brf2-in-human-non-small-cell-lung-cancer-a549-cell-line
#10
Lei Wang, Junfeng Qu, Li Zhou, Fei Liao, Ju Wang
Purpose: The purpose of this study was to investigate the biological role and mechanism of miR-373 targeting of TFIIB-related factor 2 (BRF2) in the regulation of non-small cell lung cancer (NSCLC) cells. Methods: miRNA microarray chip analysis of four paired NSCLC and adjacent non-tumor tissues was performed. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were used to detect the expression levels of miR-373 and BRF2 in NSCLC tissues and cell lines...
October 12, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28994649/planar-cell-polarity-signaling-coordinates-oriented-cell-division-and-cell-rearrangement-in-clonally-expanding-growth-plate-cartilage
#11
Yuwei Li, Ang Li, Jason Junge, Marianne Bronner
Both oriented cell divisions and cell rearrangements are critical for proper embryogenesis and organogenesis. However, little is known about how these two cellular events are integrated. Here we examine the linkage between these processes in chick limb cartilage. By combining retroviral-based multicolor clonal analysis with live imaging, the results show that single chondrocyte precursors can generate both single-column and multi-column clones through oriented division followed by cell rearrangements. Focusing on single column formation, we show that this stereotypical tissue architecture is established by a pivot-like process between sister cells...
October 10, 2017: ELife
https://www.readbyqxmd.com/read/28993569/immunolocalization-of-%C3%AE-catenin-e-cadherin-and-n-cadherin-in-neonate-and-adult-rat-kidney
#12
Naomi Terada, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
β-catenin, E-cadherin and N-cadherin are adhesion molecules that play important roles in organogenesis, tissue homeostasis, renal epithelial integrity and polarity. The present study demonstrated their immunolocalization in adult and neonate rat kidney. Membranous or cytoplasmic expression of β-catenin, E-cadherin and N-cadherin were seen in adult and developing renal tubular epithelial cells. Particularly, in adult kidney, E-cadherin and β-catenin were intensively expressed in distal renal tubules, whereas N-cadherin was expressed in proximal renal tubules...
October 6, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28993195/effect-of-trichostatin-a-on-radiation-induced-epithelial-mesenchymal-transition-in-a549%C3%A2-cells
#13
SunilGowda Sunnaghatta Nagaraja, Vishnuvarthan Krishnamoorthy, Raghavi Raviraj, Alagudinesh Paramasivam, Devipriya Nagarajan
Radiotherapy is used to treat tumors of different origins and nature, but often lead to development of radioresistance and metastasis of cells. Interestingly, radiation induces epithelial-mesenchymal transition (EMT), a process by which epithelial cells undergo mesenchymal phenotype and stimulates tumor progression capability. Our study investigated the effect of Trichostatin A (TSA), a natural derivate isolated from Streptomyces, upon radiation-induced lung EMT and we tried to understand the role of signaling molecules in irradiated lung cancer cells (A549)...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28991363/microrna-495-3p-functions-as-a-tumour-suppressor-by-regulating-multiple-epigenetic-modifiers-in-gastric-carcinogenesis
#14
Jung Woo Eun, Hyung Seok Kim, Qingyu Shen, Hee Doo Yang, Sang Yean Kim, Jung Hwan Yoon, Won Sang Park, Jung Young Lee, Suk Woo Nam
MicroRNAs (miRNAs) engage in complex interactions with the machinery that controls the transcriptome and concurrently target multiple mRNAs. Here we demonstrate that microRNA-495-3p (miR-495-3p) functions as a potent tumour suppressor by governing ten oncogenic epigenetic modifiers (EMs) in gastric carcinogenesis. From the large cohort transcriptome datasets of gastric cancer (GC) patients available from The Cancer Genome Atlas (TCGA) and the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO), we were able to recapitulate fifteen EMs as significantly overexpressed in GC among the 51 EMs that were previously reported to be involved in cancer progression...
October 9, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28987542/establishment-of-twist-1-and-tgfbr2-as-direct-targets-of-microrna-20a-in-mesenchymal-to-epithelial-transition-of-breast-cancer-cell-line-mda-mb-231
#15
Soumasree De, Sayantani Das, Srimoyee Mukherjee, Sainy Das, Sumita Sengupta Bandyopadhyay
Messenchymal to epithelial transition (MET) is a significant physiological phenomenon involved in embryogenesis and cancer. This study aims at investigating the mechanism of microRNA-20a (miR-20a) mediated regulation of mesenchymal to epithelial transition and identification of its direct target genes in breast cancer cell-line, MDA-MB-231. Reduced migratory and invasive property, altered cellular morphology along with reduced capability for attachment to basement membrane was acquired by over-expression of miR-20a in invasive MDA-MB-231 cell-line initially expressing low level of this micro-RNA, indicating direct correlation between abundance of miR-20a and metastatic property...
October 4, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28987541/robo-signaling-regulates-the-production-of-cranial-neural-crest-cells
#16
Yan Li, Xiao-Tan Zhang, Xiao-Yu Wang, Guang Wang, Manli Chuai, Andrea Münsterberg, Xuesong Yang
Slit/Robo signaling plays an important role in the guidance of developing neurons in developing embryos. However, it remains obscure whether and how Slit/Robo signaling is involved in the production of cranial neural crest cells. In this study, we examined Robo1 deficient mice to reveal developmental defects of mouse cranial frontal and parietal bones, which are derivatives of cranial neural crest cells. Therefore, we determined the production of HNK1(+) cranial neural crest cells in early chick embryo development after knock-down (KD) of Robo1 expression...
October 5, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28983895/lncrna-ghet1-promotes-esophageal-squamous-cell-carcinoma-cells-proliferation-and-invasion-via-induction-of-emt
#17
Hongfen Liu, Qiang Zhen, Yakun Fan
BACKGROUND: Recent studies have shown that long noncoding RNA (lncRNA) gastric carcinoma highly expressed transcript 1 (GHET1) was involved in the progression of tumors. However, the role of GHET1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: The expression of lncRNA GHET1 was examined in 55 paired ESCC tissues and adjacent nontumor tissues. Molecular and cellular techniques were used to explore the role of GHET1 on ESCC cells. RESULTS: Our data showed that GHET1 expression was significantly increased in ESCC tissues and cell lines...
October 4, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28983605/ldha-promotes-tumor-metastasis-by-facilitating-epithelial%C3%A2-mesenchymal-transition-in-renal-cell-carcinoma
#18
Juping Zhao, Xin Huang, Zhaoping Xu, Jun Dai, Hongchao He, Yu Zhu, Haofei Wang
Previous studies have indicated that high expression of lactate dehydrogenase A (LDHA) exists in many human cancers. Recently, several reports showed that silencing or inhibition of LDHA could suppress metastasis of human cancer including renal cell carcinoma (RCC). However, the mechanism remains unknown. The role of LDHA in RCC migration and invasion was investigated using immunohistochemistry, western blotting, Transwell and scratch assays, and in vivo experiment. The influence of LDHA on the Warburg effect was also investigated by LDHA activity and lactate production assay...
September 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28978553/ctrp9-regulates-the-fate-of-implanted-mesenchymal-stem-cells-and-mobilizes-their-protective-effects-against-ischemic-heart-injury-via-multiple-novel-signaling-pathways
#19
Wenjun Yan, Yongzhen Guo, Ling Tao, Wayne Bond Lau, Lu Gan, Zheyi Yan, Rui Guo, Erhe Gao, G William Wong, Walter L Koch, Yajing Wang, Xin-Liang Ma
Background -Cell therapy remains the most promising approach against ischemic heart injury. However, the poor survival of engrafted stem cells in the ischemic environment limits their therapeutic efficacy for cardiac repair post myocardial infarction (MI). C1q/tumor necrosis factor-related protein-9 (CTRP9) is a novel pro-survival cardiokine with significantly downregulated expression after MI. Here, we tested a hypothesis that CTRP9 might be a cardiokine required for a healthy microenvironment promoting implanted stem cell survival and cardioprotection...
October 4, 2017: Circulation
https://www.readbyqxmd.com/read/28978088/set-contributes-to-the-epithelial-mesenchymal-transition-of-pancreatic-cancer
#20
Hardik R Mody, Sau Wai Hung, Kineta Naidu, Haesung Lee, Caitlin A Gilbert, Toan Thanh Hoang, Rakesh K Pathak, Radhika Manoharan, Shanmugam Muruganandan, Rajgopal Govindarajan
Pancreatic cancer has a devastating prognosis due to 80-90% of diagnostic cases occurring when metastasis has already presented. Activation of the epithelial-mesenchymal transition (EMT) is a prerequisite for metastasis because it allows for the dissemination of tumor cells to blood stream and secondary organs. Here, we sought to determine the role of SET oncoprotein, an endogenous inhibitor of PP2A, in EMT and pancreatic tumor progression. Among the two major isoforms of SET (isoform 1 and isoform 2), higher protein levels of SET isoform 2 were identified in aggressive pancreatic cancer cell lines...
September 15, 2017: Oncotarget
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