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https://www.readbyqxmd.com/read/28815730/loss-of-bmi-1-dampens-migration-and-emt-of-colorectal-cancer-in-inflammatory-microenvironment-through-tlr4-md-2-myd88-mediated-nf-%C3%AE%C2%BAb-signaling
#1
Kai Ye, Qi-Wei Chen, Ya-Feng Sun, Jian-An Lin, Jian-Hua Xu
Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B-lymphoma Moloney murine leukemia virus insertion region 1 (BMI-1) acts as an oncogene in various tumors. Ectopic expression of Bmi-1 have an effect on EMT and invasiveness. The purpose of this study was to investigate the efficacy of BMI-1 on inflammation-induced tumor migration and EMT and the underlying mechanism...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28810836/suppression-of-agr2-in-a-tgf-%C3%AE-induced-smad-regulatory-pathway-mediates-epithelial-mesenchymal-transition
#2
Lucia Sommerova, Eva Ondrouskova, Borivoj Vojtesek, Roman Hrstka
BACKGROUND: During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representing an essential step of tumor progression towards metastatic state. AGR2 protein was shown to regulate several cancer-associated processes including cellular proliferation, survival and drug resistance. METHODS: The expression of AGR2 was analyzed in cancer cell lines exposed to TGF-β alone or to combined treatment with TGF-β and the Erk1/2 inhibitor PD98059 or the TGF-β receptor specific inhibitor SB431542...
August 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28810656/hypoxia-inducible-factor-1%C3%AE-participates-in-hypoxia-induced-epithelial-mesenchymal-transition-via-response-gene-to-complement-32
#3
Liang Zhu, Qiu Zhao
The aim of the present study was to explore the function of response gene to complement 32 (RGC-32) in hypoxia-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer. Three kinds of hypoxia-inducible factor 1α (HIF-1α) small interfering (si)RNA were synthesized and the different effects on the expression of HIF-1α were detected by western blotting. In human pancreatic cancer BxPC-3 cells, HIF-1α levels were diminished using siRNA transfection or HIF-1α inhibitor pretreatment, and the expression levels of RGC-32 and EMT-associated proteins were analyzed using reverse transcription-quantitative polymerase chain reaction and western blotting...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810650/glutathione-s-transferase-a1-mediates-nicotine-induced-lung-cancer-cell-metastasis-by-promoting-epithelial-mesenchymal-transition
#4
Wei Wang, Feiyu Liu, Chaoyang Wang, Chengde Wang, Yijun Tang, Zhongmin Jiang
The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesenchymal transition (EMT), a process strongly associated with lung cancer metastasis, was examined. Human lung carcinoma A549 cells were treated with various concentrations of nicotine (0.01, 0.1, 1 and 10 µM) and levels of GSTA1 mRNA and protein were measured by reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810525/in-vitro-anticancer-activities-of-osthole-against-renal-cell-carcinoma-cells
#5
Lei Liu, Jun Mao, Qifei Wang, Zhiwei Zhang, Guangzhen Wu, Qizhen Tang, Bin Zhao, Lianhong Li, Quanlin Li
Renal cell carcinoma (RCC) is a common urinary malignancy that is resistant to chemotherapy and radiotherapy. Osthole, a monomer compound extracted from a traditional Chinese herb, has potent anti-tumor effects on various types of cancer cells. However, the therapeutic effects of osthole on RCC remain unclear. In our study, osthole could suppress the proliferation and colony formation of two RCC cell lines, ACHN and 786-O cells, in a dose-dependent manner. Treatment with osthole resulted in a significant, dose-dependent increase in the expression of pro-apoptotic proteins (cleaved caspase-3 and Bax) and decreased expression of anti-apoptotic proteins (Bcl-2 and survivin), which were consistent with evidence of apoptotic nuclear morphology revealed by DAPI staining...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28808957/differential-effect-of-tgf%C3%AE-on-the-proteome-of-cancer-associated-fibroblasts-and-cancer-epithelial-cells-in-a-co-culture-approach-a-short-report
#6
Maria Magdalena Koczorowska, Charlotte Friedemann, Klaus Geiger, Marie Follo, Martin Lothar Biniossek, Oliver Schilling
BACKGROUND: Solid tumors contain various components that together form the tumor microenvironment. Cancer associated fibroblasts (CAFs) are capable of secreting and responding to signaling molecules and growth factors. Due to their role in tumor development, CAFs are considered as potential therapeutic targets. A prominent tumor-associated signaling molecule is transforming growth factor β (TGFβ), an inducer of epithelial-to-mesenchymal transition (EMT). The differential action of TGFβ on CAFs and ETCs (epithelial tumor cells) has recently gained interest...
August 14, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28806534/knockdown-of-snail-inhibits-epithelial-mesenchymal-transition-of-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-through-vdr-signaling-pathway
#7
Xue Zhao, Dan Yu, Jingpu Yang, Kai Xue, Yan Liu, Chunshun Jin
It has been well-documented that Snail plays a decisive role in various tumors. However, the direct effect of Snail on laryngeal squamous cell carcinoma (LSCC) has not been elaborated. In this study, we firstly detected the expression of Snail in 14 samples of patients with LSCC and found that its content was high in cancer tissues compared with adjacent tissues. Then we established LSCC Hep-2 cells with Snail silencing and validated the knockdown efficiency by western blotting and real-time PCR. Results showed that silencing of Snail significantly inhibited the ability of adhesion, migration, and invasion of Hep-2 cells...
August 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28804564/incrna-h19-promotes-tongue-squamous-cell-carcinoma-progression-through-%C3%AE-catenin-gsk3%C3%AE-emt-signaling-via-association-with-ezh2
#8
Da-Ming Zhang, Zhao-Yu Lin, Zhao-Hui Yang, You-Yuan Wang, Di Wan, Jiang-Long Zhong, Pei-Lin Zhuang, Zhi-Quan Huang, Bin Zhou, Wei-Liang Chen
H19 is involved in tumor metastasis and associated with tumor progression. Enhancer of zest homolog 2 (EZH2) is overexpressed in multiple cancer types and correlates with tumor proliferation, epithelial-mesenchymal transition, and poor prognosis. However, the interaction between H19 and EZH2 to promote tongue squamous cell carcinoma (TSCC) progression remains largely uncharacterized. Insitu hybridization and quantitative reverse-transcription PCR (qRT-PCR) were performed to measure H19 expression in primary TSCC and adjacent normal tissues and cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803991/dhea-increases-epithelial-markers-and-decreases-mesenchymal-proteins-in-breast-cancer-cells-and-reduces-xenograft-growth
#9
Zaira Colín-Val, Viridiana Yazmín González-Puertos, Criselda Mendoza-Milla, Erika Olivia Gómez, Claudia Huesca-Gómez, Rebeca López-Marure
Breast cancer is one of the most common neoplasias and the leading cause of cancer death in women worldwide. Its high mortality rate is linked to a great metastatic capacity associated with the epithelial-mesenchymal transition (EMT). During this process, a decrease in epithelial proteins expression and an increase of mesenchymal proteins are observed. On the other hand, it has been shown that dehydroepiandrosterone (DHEA), the most abundant steroid in human plasma, inhibits migration of breast cancer cells; however, the underlying mechanisms have not been elucidated...
August 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28802099/cancer-associated-fibroblasts-autophagy-enhances-progression-of-triple-negative-breast-cancer-cells
#10
Mengchuan Wang, Jian Zhang, Yizhe Huang, Shufeng Ji, Guoli Shao, Shaobo Feng, Danxun Chen, Kankan Zhao, Zixiang Wang, Aiguo Wu
BACKGROUND Cancer-associated fibroblasts (CAFs) are key factors in malignant tumor initiation, progression, and metastasis. However, the effect of CAFs autophagy on triple-negative breast cancer (TNBC) cells is not clear. In this study, the growth effect of TNBC cells regulated by CAFs autophagy was evaluated. MATERIAL AND METHODS CAFs were obtained from invasive TNBC tumors and identified by Western blot and immunofluorescence staining assay. CAFs were co-cultured with TNBC cells, and migration and invasion were evaluated by Matrigel-coated Transwell and Transwell inserts...
August 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28801289/-lkb1-regulates-epithelial-mesenchymal-transition-in-peutz-jeghers-hamartoma-and-intestinal-epithelial-cells
#11
Chao Zhong, Liang Peng, Ran Li, Jing Chen, Xin-Qi Chen, Di Zeng, Xiao-Ping Xu, Zhi-Qing Wang, Chu-di Chen, Ya-Dong Wang, Ai-Min Li, Si-de Liu, Bao-Ping Wu
OBJECTIVE: To investigate the molecular mechanism by which LKB1 regulates epithelial-mesenchymal transition (EMT) in Peutz-Jeghers hamartoma and intestinal epithelial cells. METHODS: Immunohistochemistry was used to detect gene expression of LKB1, E-cadherin, and vimentin in 20 hamartoma tissues and 10 normal intestinal tissues, and collagen fiber deposition was analyzed using Masson trichrome staining. Normal intestinal epithelial NCM460 cells were transfected with LKB1 shRNA plasmid or negative control via lentiviral vectors, and the role of LKB1 in cell polarization and migration were determined using CCK8 and Transwell assays...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28798691/fentanyl-promotes-breast-cancer-cell-stemness-and-epithelial-mesenchymal-transition-by-upregulating-%C3%AE-1-6-fucosylation-via-wnt-%C3%AE-catenin-signaling-pathway
#12
Hong-Fang Yang, Ming Yu, Hui-Dan Jin, Jia-Qi Yao, Zhi-Li Lu, Iddrisu B Yabasin, Qiu Yan, Qing-Ping Wen
Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on stemness and epithelial-mesenchymal transition (EMT) of breast cancer cells. Aberrant protein glycosylation is involved in cancer malignancy. The α1, 6-fucosylation is an important type of glycosylation, and the elevated α1, 6-fucosylation catalyzed by fucosyltransferase VIII (FUT8) is found in many tumors...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28796315/senp1-hif-1%C3%AE-feedback-loop-modulates-hypoxia-induced-cell-proliferation-invasion-and-emt-in-human-osteosarcoma-cells
#13
Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang
Hypoxia is an element intrinsic to most solid-tumor microenvironments, including that of osteosarcoma (OS), and is associated with resistance to therapy, poor survival, and a malignant phenotype. The purpose of the present study was to investigate the role and underlying mechanism of SUMO-specific protease 1 (SENP1)/hypoxia-inducible factor-1α (HIF-1α) feedback loop in hypoxic microenvironment of OS. We observed that the expression of SENP1 was remarkably upregulated in OS cells. Additionally, there was a concomitant high expression of HIF-1α and SENP1 in MG-63 cells under a hypoxic microenvironment...
August 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28791754/endothelial-precursor-cells-stimulate-pericyte-like-coverage-of-bone-marrow-derived-mesenchymal-stem-cells-through-pdgf-bb-induction-which-is-enhanced-by-substance-p
#14
Mingzi Zhang, Woosung Ahn, Sumin Kim, Hyun Sook Hong, Chengshi Quan, Youngsook Son
OBJECTIVE: The aim of this study was to evaluate the angiogenicity of a combination of bone marrow-derived endothelial precursor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) in vitro in the presence of substance P (SP), and its working mechanism. METHODS: BM-MSCs and BM-EPCs were co-cultured with or without SP. ELISA and RT-PCR were performed to detect angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB)...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791412/benzo-a-pyrene-enhances-the-emt-associated-migration-of-lung-adenocarcinoma-a549-cells-by-upregulating-twist1
#15
Xi Chen, Hongbing Peng, Jian Xiao, Anqi Guan, Bin Xie, Bixiu He, Qiong Chen
Benzo(a)pyrene (BaP), an important toxic component of cigarette smoke, can cause lung cancer and lead to the progression of lung cancer. In the present study, we investigated the effect of BaP on the migration of lung adenocarcinoma A549 cells. BaP (1 µM) promoted the migration of A549 cells in a time-dependent manner and upregulated the expression of the Twist family BHLH transcription factor 1 (Twist1). BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin...
August 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28782471/tgf-%C3%AE-1-causes-emt-by-regulating-n-acetyl-glucosaminyl-transferases-via-downregulation-of-non-muscle-myosin-ii-a-through-jnk-p38-pi3k-pathway-in-lung-cancer
#16
Ghulam Jilany Khan, Yingsheng Gao, Ming Gu, Lai Wang, Sara Khan, Farah Naeem, Bashir Alsiddig Yousef, Debmalya Roy, Herve Semukunzi, Shengtao Yuan, Li Sun
BACKGROUND: Epithelial to mesenchymal transition (EMT) is a major determinant of cancer metastasis and is closely linked with TGF-β1. Intracellular proteins, including E. Cadherin, N. Cadherin and Vimentin are directly related to EMT that affect cell migration and adhesion; on the other hand, non muscle myosin (NM) has a central role in cytokinesis, migration and adhesion. OBJECTIVE: We aimed to explore the association of EMT and metastasis with TGF-β1 through regulation of non-muscle myosin II-A (NMII-A) and its interaction with Hexosamine Biosynthesis Pathway (HBP)...
August 7, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28775239/reversion-of-epithelial-mesenchymal-transition-by-a-novel-agent-dz-50-via-igf-binding-protein-3-in-prostate-cancer-cells
#17
Zheng Cao, Shahriar Koochekpour, Stephen E Strup, Natasha Kyprianou
Dysregulation of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor (IGF) axis has been linked to reactive stroma dynamics in prostate cancer progression. IGF binding protein-3 (IGFBP3) induction is initiated by stroma remodeling and could represent a potential therapeutic target for prostate cancer. In previous studies a lead quinazoline-based Doxazosin® derivative, DZ-50, impaired prostate tumor growth by targeting proteins involved in focal adhesion, anoikis resistance and epithelial-mesenchymal-transition (EMT)...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28771711/tannic-acid-attenuates-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-by-effectively-intervening-tgf-%C3%AE-signaling-in-lung-epithelial-cells
#18
Dhamotharan Pattarayan, Ayyanar Sivanantham, Venkateshwaran Krishnaswami, Lakshmanan Loganathan, Rajaguru Palanichamy, Subramanian Natesan, Karthikeyan Muthusamy, Subbiah Rajasekaran
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and an irreversible lung disorder characterized by the accumulation of fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) is thought to be one of the possible sources for a substantial increase in the number of fibroblasts/myofibroblasts in IPF lungs. Tannic acid (TA), a natural dietary polyphenolic compound has been shown to possess diverse pharmacological effects...
August 3, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28771223/pigment-epithelium-derived-factor-promotes-tumor-metastasis-through-an-interaction-with-laminin-receptor-in-hepatocellular-carcinomas
#19
Jianjing Hou, Chao Ge, Meiling Cui, Tengfei Liu, Xiaoqin Liu, Hua Tian, Fangyu Zhao, Taoyang Chen, Ying Cui, Ming Yao, Jinjun Li, Hong Li
Pigment epithelium-derived factor (PEDF) has complex functions in tumor metastasis, but little is known about the roles of PEDF and its receptors in hepatocellular carcinoma (HCC). Here we found that high expression of PEDF is associated with shorter overall survival in HCC patients. Forced expression of PEDF enhanced HCC cell aggressive behavior in vitro and in vivo, whereas silencing PEDF expression reduced migration and invasion. Furthermore, PEDF expression led to changes in cell morphology and the expression of epithelial-mesenchymal transition (EMT)-related markers via ERK1/2 signaling pathway, including the upregulation of N-cadherin and slug, and the downregulation of E-cadherin in HCC cells...
August 3, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28765930/e%C3%A2-cadherin-involvement-in-human-lens-epithelial-cell-transdifferentiation-may-be-associated-with-n%C3%A2-cadherin
#20
Lei Huang, Jie Jiang, Qiang Guo, Hongbin Yang
E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation. SRA01/04 human LECs were transfected with E‑cadherin short interfering (si)RNA (E‑cadherin siRNA group), negative control siRNA (NC group) or the transfection regent Lipofectamine 2000 (blank group). Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect mRNA expression levels of E‑cadherin, N‑cadherin and β‑catenin, and western blot analysis was performed to measure the protein expression levels in the three groups...
August 2, 2017: Molecular Medicine Reports
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