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Cirrhosis and diastolic function

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https://www.readbyqxmd.com/read/27822933/hemorheological-alteration-in-patients-clinically-diagnosed-with-chronic-liver-diseases
#1
Bohyun Jang, Ji Won Han, Pil Soo Sung, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Young I Cho, Seung Kew Yoon
Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient's history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35)...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27458853/galactin-3-and-brain-natriuretic-peptide-versus-conventional-echocardiography-in-the-early-detection-of-cirrhotic-cardiomyopathy
#2
Wael A Abbas, Soheir M Kasem Ahmed, Amal M Abdel Aal, Amal A Mahmoud, Mohamed O Abdelmalek, Mohamed A Mekky, Mohamed A A Abozaid, Ahmed K Ibrahim
BACKGROUND/AIMS: Cirrhotic cardiomyopathy (CCM) is defined as an abnormal heart structure and function in cirrhotic patients. CCM includes systolic and diastolic dysfunction, electrophysiological abnormalities, and structural changes, both microscopic and macroscopic. Currently, there is no one diagnostic test that can identify patients with CCM. Evaluation of the validity of galactin-3 and brain natriuretic peptide (BNP) as biomarkers in the early detection of CCM in comparison to conventional echocardiography...
July 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27382936/fragmented-qrs-is-associated-with-cirrhotic-cardiomyopathy-in-patients-with-decompensated-cirrhosis
#3
M Demir, M Kurt, A B Akçay
BACKGROUND AND AIM: It has been reported that the fragmented QRS (fQRS) is related to left ventricular systolic dysfunction and diastolic dysfunction. The aim of this study was to determine the frequency of fragmented QRS (fQRS) in patients with decompensated cirrhosis and to evaluate the relationship between the presence of fQRS and systolic and diastolic dysfunction. METHOD: PThe study included consecutive 189 patients with decompensated cirrhosis. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings...
April 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/26932686/altered-circadian-hemodynamic-and-renal-function-in-cirrhosis
#4
Suthat Liangpunsakul, Rajiv Agarwal
BACKGROUND: Given that alterations in systemic hemodynamics have a profound influence on renal function in patients with cirrhosis, it is surprising that circadian variations in blood pressure (BP) and renal electrolyte excretion have scarcely been studied. Our aims were to define the relationship of 24-h ambulatory BP changes with renal tubular function and to determine the influence of endotoxemia on BP and urinary parameters. METHODS: Forty healthy controls served as a comparator to 20 cirrhotic patients...
February 29, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26556983/cirrhotic-cardiomyopathy
#5
REVIEW
Luis Ruiz-del-Árbol, Regina Serradilla
During the course of cirrhosis, there is a progressive deterioration of cardiac function manifested by the disappearance of the hyperdynamic circulation due to a failure in heart function with decreased cardiac output. This is due to a deterioration in inotropic and chronotropic function which takes place in parallel with a diastolic dysfunction and cardiac hypertrophy in the absence of other known cardiac disease. Other findings of this specific cardiomyopathy include impaired contractile responsiveness to stress stimuli and electrophysiological abnormalities with prolonged QT interval...
November 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26545992/evaluation-of-cardiac-systolic-function-in-cirrhotic-patients-undergoing-liver-transplantation
#6
Roya Sattarzadeh-Badkoubeh, Babak Geraiely, Mohssen Nassiri-Toosi, Ali Jafarian
We assessed different systolic cardiac indices to detect left and right ventricular systolic dysfunction in cirrhotic patients before liver transplantation. Between 2010-2011, 81 consecutive individuals with confirmed hepatic cirrhosis who were a candidate for liver transplantation were enrolled in this study. A total of 32 age and sex matched healthy volunteers were also selected as the control group. A detailed two-dimensional, Color Flow Doppler, and Tissue Doppler echocardiography were performed in all patients and control participants...
August 2015: Acta Medica Iranica
https://www.readbyqxmd.com/read/26488381/galectin-3-levels-in-patients-with-hypertrophic-cardiomyopathy-and-its-relationship-with-left-ventricular-mass-index-and-function
#7
Selcen Yakar Tülüce, Kamil Tülüce, Zafer Çil, Sadık Volkan Emren, Zehra İlke Akyıldız, Oktay Ergene
OBJECTIVE: Cardiac fibrosis is an important contributor to adverse left ventricular (LV) remodeling and arrhythmias in patients with hypertrophic cardiomyopathy (HCM). Galectin-3 (Gal-3) is a novel marker of cardiac fibrosis and inflammation. In this study, we investigated Gal-3 levels in patients with HCM and controls and assessed the relationship between Gal-3 level and echocardiographic indices using strain echocardiography in patients with HCM. METHODS: Forty patients with HCM in sinus rhythm and 35 healthy controls were prospectively enrolled in this case-control study...
May 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/26462482/cardiac-abnormalities-in-cirrhotic-children-pre-and-post-liver-transplantation
#8
Khemika Khemakanok, Anant Khositseth, Suporn Treepongkaruna, Sumate Teeraratkul, Wichai Pansrimangkorn, Surasak Leelaudomlipi, Uthen Bunmee, Suthus Sriphojanart
BACKGROUND/AIM: Liver cirrhosis is associated with several cardiac abnormalities. There have been few studies of these abnormalities in cirrhotic children post-liver transplantation (LT). The purpose of this study was to evaluate cardiac abnormalities in cirrhotic children pre- and post-LT. METHODS: All cirrhotic children <15 years of age on a waiting list for LT underwent pre-LT echocardiography to evaluate left ventricular (LV) dimension, mass, and function...
May 2016: Hepatology International
https://www.readbyqxmd.com/read/26304615/a-detailed-evaluation-of-cardiac-function-in-cirrhotic-patients-and-its-alteration-with-or-without-liver-transplantation
#9
Yan Chen, Albert C Chan, See-Ching Chan, Siu-Ho Chok, William Sharr, James Fung, Ju-Hua Liu, Zhe Zhen, Wai-Ching Sin, Chung-Mau Lo, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: Cirrhosis has been shown to be associated with left ventricular (LV) myocardial dysfunction, but studies of right ventricular (RV) function in cirrhotic patients compared with controls are scarce. Limited studies have prospectively evaluated the progression of myocardial function in patients with cirrhosis and assessed changes in cardiac function following liver transplantation (LTx). So the aim of the study was to evaluate biventricular myocardial function in cirrhotic patients and its alteration with or without liver transplantation...
February 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/26202764/diastolic-cardiac-dysfunction-is-a-predictor-of-dismal-prognosis-in-patients-with-liver-cirrhosis
#10
Dimitrios S Karagiannakis, Jiannis Vlachogiannakos, Georgios Anastasiadis, Irini Vafiadis-Zouboulis, Spiros D Ladas
BACKGROUND AND PURPOSE: Left ventricular diastolic dysfunction (LVDD) constitutes the prominent characteristic of cirrhotic cardiomyopathy, but its relevance on the clinical course of cirrhotic patients has not been clearly defined. The aim of the study was to evaluate the relationship of LVDD with the severity and etiology of liver disease and to investigate whether it affects the outcome of cirrhotic patients. METHODS: Cardiac function of 45 cirrhotics was studied by a tissue Doppler imaging echocardiography...
October 2014: Hepatology International
https://www.readbyqxmd.com/read/26174780/left-ventricular-myocardial-mechanics-in-cirrhosis-a-speckle-tracking-echocardiographic-study
#11
Efstathios D Pagourelias, Panagiota Sotiriou, Christodoulos E Papadopoulos, Evaggelos Cholongitas, Olga Giouleme, Vassilios Vassilikos
Cirrhosis is commonly associated with impaired left ventricular (LV) myocardial contractile reserve to stress and diastolic dysfunction. The aim of this study was to assess LV systolic performance at rest, using both "standard" echocardiographic indices and novel deformation-rotational parameters, in order to elucidate the pathophysiologic basis of cardiac dysfunction in cirrhosis. Seventy-seven men with cirrhosis (mean age 54.4 ± 9.7) of variable Child-Pugh class (A, B, C) and 20 healthy control subjects were prospectively evaluated by standard as well as speckle tracking echocardiography...
February 2016: Echocardiography
https://www.readbyqxmd.com/read/26065511/cardiac-involvement-in-patients-with-cirrhosis-a-focus-on-clinical-features-and-diagnosis
#12
REVIEW
Anna Licata, Giuseppina Novo, Daniela Colomba, Antonino Tuttolomondo, Massimo Galia, Calogero Camma'
Cirrhotic heart has been traditionally considered protected from cardiovascular disease, even if a large amount of literature has recently shown that patients affected by chronic liver disease are exposed to cardiovascular events, as well. Since the first recognition of cardiac involvement in cirrhosis, all published studies explain that decompensated cirrhotic patients suffer from haemodynamic changes, currently known as hyperdynamic syndrome, which finally lead to cirrhotic cardiomyopathy. This is defined by the presence of a subclinical systolic dysfunction unmasked under stress conditions, impaired diastolic function and electrophysiological abnormalities, in the absence of any known cardiac disease...
January 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/26011993/-cirrhotic-cardiomyopathy-a-brief-overview
#13
REVIEW
S Marchetta, J Delwaide, R Lancellotti
Even though cardiac disorders were described in alcoholic cirrhosis more than fifty years ago, cirrhotic cardiomyopathy was not defined until the end of the eighties. The term is used to describe all the cardiac structural and functional abnormalities observed in cirrhotic patients without any underlying cardiac disease. This cardiomyopathy is characterized by impaired systolic function, often unmasked during stress, diastolic dysfunction, and electrophysiological abnormalities. It can be detected by the electrocardiogram, transthoracic echocardiography and measurements of cardiac biomarkers (BNP)...
February 2015: Revue Médicale de Liège
https://www.readbyqxmd.com/read/25934564/the-art-and-science-of-diagnosing-and-treating-lung-and-heart-disease-secondary-to-liver-disease
#14
REVIEW
David S Goldberg, Michael B Fallon
Patients with chronic liver disease are at risk of extrahepatic complications related to cirrhosis and portal hypertension, as well as organ-specific complications of certain liver diseases. These complications can compromise quality of life, while also increasing morbidity and mortality before and after liver transplantation. Patients with chronic liver disease are at risk for pulmonary complications of hepatopulmonary syndrome and portopulmonary syndrome; the cardiac complication fall under the general concept of cirrhotic cardiomyopathy, which can affect systolic and diastolic function, as well as cardiac conduction...
November 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25923940/cardiac-dysfunction-in-patients-with-cirrhosis-is-the-systolic-component-its-main-feature
#15
Maurizio Cesari, Silvano Fasolato, Silvia Rosi, Paolo Angeli
OBJECTIVE: To investigate the subclinical cardiac morphological and functional modifications in cirrhotic patients according to the stage of liver disease. PATIENTS AND METHODS: One hundred and thirteen cirrhotic patients underwent standard Doppler echocardiography and were compared with healthy individuals. Left ventricular (LV) geometry, systolic/diastolic function, and the main hemodynamic parameters were assessed according to current guidelines. RESULTS: Cirrhotic patients showed a reduction in the peripheral vascular resistance (PVR), a compensatory hyperdynamic syndrome, and a significant increase in cardiac index (CI), cardiac output (CO), and cardiac work, with a consequent increase in the prevalence of LV hypertrophy and associated diastolic dysfunction (DD)...
June 2015: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25907944/-changes-of-left-ventricular-function-in-cirrhotic-patients-and-their-correlation-with-the-model-for-end-stage-liver-disease-score
#16
Xiao-Peng Li, Shan-Shan Yu, Lu Li, Dong-Gang Han, She-Jiao Dai, Ya Gao
OBJECTIVE: To investigate the changes of left ventricular structure and function in patients with liver cirrhosis and their correlation with the model for end-stage liver disease (MELD) score. METHODS: A total of 89 cirrhotic patients admitted between June, 2012 and June, 2014 and 30 healthy control subjects were enrolled in the study. According to MELD score, the cirrhotic patients were divided into 3 groups with MELD scores ≤9, between 10 and 19, and ≥20. The parameters of the left ventricle in resting state were measured using Doppler echocardiography, including left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left atrial diameter (LAD), ejection fraction (LVEF), cardiac output (CO), mitral flow velocity, and E wave deceleration time (DT), and evaluated their relationship with MELD score...
April 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/25634400/diastolic-dysfunction-characterizes-cirrhotic-cardiomyopathy
#17
Piyush O Somani, Qais Contractor, Ajay S Chaurasia, Pravin M Rathi
AIM: Present study aims to study the occurrence of cirrhotic cardiomyopathy and its correlation to hepatorenal syndrome by assessing the cardiac status in patients with cirrhosis of liver and healthy controls. METHODS: Thirty alcoholic cirrhotic, thirty non-alcoholic cirrhotic and thirty controls were enrolled for the study. Cardiac parameters were assessed by color doppler echocardiography. Patients were followed up for twelve months period for development of hepatorenal syndrome...
November 2014: Indian Heart Journal
https://www.readbyqxmd.com/read/25404411/recent-advances-in-cirrhotic-cardiomyopathy
#18
REVIEW
Dimitrios S Karagiannakis, George Papatheodoridis, Jiannis Vlachogiannakos
Cirrhotic cardiomyopathy, a cardiac dysfunction presented in patients with cirrhosis, represents a recently recognized clinical entity. It is characterized by altered diastolic relaxation, impaired contractility, and electrophysiological abnormalities, in particular prolongation of the QT interval. Several mechanisms seem to be involved in the pathogenesis of cirrhotic cardiomyopathy, including impaired function of beta-receptors, altered transmembrane currents, and overproduction of cardiodepressant factors, like nitric oxide, tumor necrosis factor α, and endogenous cannabinoids...
May 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25279659/cardiac-function-in-patients-with-early-cirrhosis-during-maximal-beta-adrenergic-drive-a-dobutamine-stress-study
#19
Aleksander Krag, Flemming Bendtsen, Emilie Kristine Dahl, Andreas Kjær, Claus Leth Petersen, Søren Møller
BACKGROUND AND AIM: Cardiac dysfunction in patients with early cirrhosis is debated. We investigated potential cardiac dysfunction by assessing left ventricular systolic performance during a dobutamine stress test in patients with early cirrhosis. PATIENTS AND METHODS: Nineteen patients with Child A and B cirrhosis (9 with non-alcoholic cirrhosis) and 7 matched controls were included. We used cardiac magnetic resonance imaging to assess left ventricular volumes and cardiac output (CO) at rest and during maximal heart rate induced by increasing dosages of dobutamine and atropine...
2014: PloS One
https://www.readbyqxmd.com/read/25267959/pathophysiological-and-clinical-approach-to-cirrhotic-cardiomyopathy
#20
REVIEW
Alida Páll, Arpád Czifra, Zsuzsanna Vitális, Mária Papp, György Paragh, Zoltán Szabó
Hyperdynamic circulation, systolic and diastolic left ventricular dysfunction and certain electrophysiological abnormalities have been associated with cirrhosis and known for a long time. These clinical features have been introduced as cirrhotic cardiomyopathy (CCM), which is characterized by blunted myocardial contractile responsiveness to physical, physiological and pharmacological stress. Importantly, cardiac dysfunction can be reversible and can improve due to effective medical treatment and also after liver transplantation...
September 2014: Journal of Gastrointestinal and Liver Diseases: JGLD
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