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https://www.readbyqxmd.com/read/27910108/a-day-in-the-life-of-a-m%C3%A3-ni%C3%A3-re-s-patient-understanding-the-lived-experiences-and-mental-health-impacts-of-m%C3%A3-ni%C3%A3-re-s-disease
#1
Sarah L Bell, Jessica Tyrrell, Cassandra Phoenix
Concepts of social practice are increasingly being used to understand experiences of everyday life, particularly in relation to consumption and healthy lifestyles. This article builds on this in the context of lives disrupted and reshaped by chronic illness. It uses social practice theory to examine the lived experiences of individuals with Ménière's disease; a long-term progressive vestibular disorder, defined by episodes of severe and debilitating vertigo, aural fullness, tinnitus and sensorineural hearing loss...
December 2, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27910089/bilateral-endolymphatic-hydrops-in-a-patient-with-migraine-variant-without-vertigo-a-case-report
#2
Isabelle Y Liu, Akira Ishiyama, Ali R Sepahdari, Kevin Johnson, Gail Ishiyama
OBJECTIVE: To use modern high-resolution inner ear imaging modalities to evaluate for endolymphatic hydrops (EH) in a patient with migraine-associated fluctuating hearing loss without vertigo spells or dizziness. BACKGROUND: EH has been well described in patients with Meniere's disease on both human temporal bone studies and modern high-resolution imaging; however, there is no study to date, to our knowledge, that examines the presence of EH in a patient with migraine and bilateral hearing loss...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27876815/variable-expressivity-and-genetic-heterogeneity-involving-dpt-and-sema3d-genes-in-autosomal-dominant-familial-meniere-s-disease
#3
Carmen Martín-Sierra, Alvaro Gallego-Martinez, Teresa Requena, Lidia Frejo, Angel Batuecas-Caletrío, Jose A Lopez-Escamez
Autosomal dominant (AD) familial Meniere's disease (FMD) is a rare disorder involving the inner ear defined by sensorineural hearing loss, tinnitus and episodic vertigo. Here, we have identified two novel and rare heterozygous variants in the SEMA3D and DPT genes segregating with the complete phenotype that have variable expressivity in two pedigrees with AD-FMD. A detailed characterization of the phenotype within each family illustrates the clinical heterogeneity in the onset and progression of the disease...
November 23, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27872606/an-exploratory-study-to-detect-m%C3%A3-ni%C3%A3-re-s-disease-in-conventional-mri-scans-using-radiomics
#4
E L van den Burg, M van Hoof, A A Postma, A M L Janssen, R J Stokroos, H Kingma, R van de Berg
OBJECTIVE: The purpose of this exploratory study was to investigate whether a quantitative image analysis of the labyrinth in conventional magnetic resonance imaging (MRI) scans using a radiomics approach showed differences between patients with Ménière's disease (MD) and the control group. MATERIALS AND METHODS: In this retrospective study, MRI scans of the affected labyrinths of 24 patients with MD were compared to the MRI scans of labyrinths of 29 patients with an idiopathic asymmetrical sensorineural hearing loss...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27868031/therapeutic-illusion-another-frontier-in-m%C3%A3-ni%C3%A3-re-s-disease
#5
COMMENT
Nicolas Pérez-Fernández, Eduardo Martín-Sanz
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27865535/intratympanic-methylprednisolone-versus-gentamicin-in-patients-with-unilateral-m%C3%A3-ni%C3%A3-re-s-disease-a-randomised-double-blind-comparative-effectiveness-trial
#6
Mitesh Patel, Kiran Agarwal, Qadeer Arshad, Mohamed Hariri, Peter Rea, Barry M Seemungal, John F Golding, Jonny P Harcourt, Adolfo M Bronstein
BACKGROUND: Ménière's disease is characterised by severe vertigo attacks and hearing loss. Intratympanic gentamicin, the standard treatment for refractory Ménière's disease, reduces vertigo, but damages vestibular function and can worsen hearing. We aimed to assess whether intratympanic administration of the corticosteroid methylprednisolone reduces vertigo compared with gentamicin. METHODS: In this double-blind comparative effectiveness trial, patients aged 18-70 years with refractory unilateral Ménière's disease were enrolled at Charing Cross Hospital (London, UK) and Leicester Royal Infirmary (Leicester, UK)...
November 16, 2016: Lancet
https://www.readbyqxmd.com/read/27865534/m%C3%A3-ni%C3%A3-re-s-disease-damaged-hearing-but-reduced-vertigo
#7
Steven D Rauch
No abstract text is available yet for this article.
November 16, 2016: Lancet
https://www.readbyqxmd.com/read/27864211/steroid-injections-through-the-eardrum-reduce-dizziness-in-meniere-s-disease-study-finds
#8
Susan Mayor
No abstract text is available yet for this article.
November 17, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27861300/the-weather-and-m%C3%A3-ni%C3%A3-re-s-disease-a-longitudinal-analysis-in-the-uk
#9
Wiebke Schmidt, Christophe Sarran, Natalie Ronan, George Barrett, David J Whinney, Lora E Fleming, Nicholas J Osborne, Jessica Tyrrell
HYPOTHESIS: Changes in the weather influence symptom severity in Ménière's disease (MD). BACKGROUND: MD is an unpredictable condition that significantly impacts on quality of life. It is suggested that fluctuations in the weather, especially atmospheric pressure may influence the symptoms of MD. However, to date, limited research has investigated the impact of the weather on MD. METHODS: In a longitudinal study, a mobile phone application collected data from 397 individuals (277 females and 120 males with an average age of 50 yr) from the UK reporting consultant-diagnosed MD...
November 17, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27861194/cochlear-implantation-in-m%C3%A3-ni%C3%A3-re-s-disease-with-and-without-labyrinthectomy
#10
Payal Mukherjee, Kate Eykamp, Daniel Brown, Ian Curthoys, Sean Flanagan, Nigel Biggs, Celene McNeill, William Gibson
OBJECTIVE: To investigate outcomes of cochlear implantation (CI) in patients with Ménière's disease (MD) with and without surgical labyrinthectomy. STUDY DESIGN: Retrospective study. SETTING: Multiple tertiary referral centers. SUBJECTS: Thirty one ears from 27 patients (17 men, 10 women, aged 42-84) with CI in ipsilateral MD ear. INTERVENTION: CI in ears with intact labyrinths (Group 1), CI with simultaneous surgical labyrinthectomy (Group 2), and CI sequential to surgical labyrinthectomy (Group 3)...
November 16, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27855527/recent-advances-in-therapeutics-and-drug-delivery-for-the-treatment-of-inner-ear-diseases-a-patent-review-2011-2015
#11
Kim Nguyen, Judith S Kempfle, David H Jung, Charles E McKenna
Inner ear disorders such as hearing loss, tinnitus, and Ménière's disease significantly impact the quality of life of affected individuals. Treatment of such disorders is an ongoing challenge. Current clinical approaches relieve symptoms but do not fully restore hearing, and the search for more effective therapeutic methods represents an area of urgent current interest. Areas covered: Thirty four patents and patent applications published from 2011 to 2015 were selected from the database of the U.S. Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO), covering new approaches for the treatment of inner ear disorders described in the patent literature: 1) identification of new therapeutic agents, 2) development of sustained release formulations, and 3) medical devices that facilitate delivery of such agents to the inner ear...
November 18, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27851655/history-of-the-endolymphatic-sac-from-anatomy-to-surgery
#12
C Eduardo Corrales, Albert Mudry
OBJECTIVES: To evaluate the historical descriptive origins of the anatomy of endolymphatic sac (ELS), its initial dilation description, its association with tumors, and lastly its surgical implication. METHODS: A collection of historical and contemporary references, and selected textbooks were compiled spanning the 18th century to present day with specific focus on the description of the ELS, ELS dilation, and ELS tumors (ELSTs). RESULTS: Domenico Cotugno describes the ELS in 1760...
November 15, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27846752/chronic-cerebrospinal-venous-insufficiency-as-a-cause-of-inner-ear-diseases
#13
Giuseppe Attanasio, Laura Cagnoni, Eleonora Masci, Francesco Ciciarello, Francesco Diaferia, Aldo Bruno, Antonio Greco, Marco De Vincentiis
CONCLUSION: The present study confirms a correlation between chronic cerebrospinal venous insufficiency (CCSVI) diagnosis and Ménière's disease (MD). CCSVI could be considered a new ultrasound vascular pattern of the cerebrospinal venous system in patients affected by definite MD. Conversely, the present results showed that CCSVI cannot be considered a pathogenic mechanism for idiopathic sudden sensorineural hearing loss (ISSNHL). OBJECTIVES: The aim of this study is to investigate the correlation between CCSVI and MD and to evaluate if CCSVI can be considered a risk factor also for ISSNHL...
November 16, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27837419/genetics-of-ion-homeostasis-in-m%C3%A3-ni%C3%A3-re-s-disease
#14
Roberto Teggi, Laura Zagato, Simona Delli Carpini, Lorena Citterio, Claudia Cassandro, Roberto Albera, Wen-Yi Yang, Jan A Staessen, Mario Bussi, Paolo Manunta, Chiara Lanzani
Aim of this work was to assess the role of polymorphisms belonging to genes involved in the regulation of ionic homeostasis in Caucasian patients with Ménière Disease (MD). We recruited 155 patients with definite Ménière Disease and 186 controls (Control Group 1) without a lifetime history of vertigo, overlapping with patients for age and rate of hypertension. We validated the positive results on 413 Caucasian subjects selected from a European general population (Control Group 2). The clinical history for migraine and hypertension was collected; genomic DNA was characterized for a panel of 33 SNPs encoding proteins involved in ionic transport...
November 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27837211/-modern-imaging-of-the-temporal-bone
#15
S Kösling
This article describes the current significance of computed tomography (CT), magnetic resonance imaging (MRI), cone beam CT, digital subtraction angiography (DSA), and special X‑rays in the diagnostics of temporal bone diseases. The latter is obsolete for diagnostic intentions. Possibilities and limitations in terms of detection and/or depiction of the extent of inflammatory, traumatic, tumorous, and postoperative pathologies are discussed. A concrete question and conveyance of clinical findings influence the choice of the method to be applied in the individual case...
November 11, 2016: HNO
https://www.readbyqxmd.com/read/27829169/slc44a2-single-nucleotide-polymorphisms-isoforms-and-expression-association-with-severity-of-meniere-s-disease
#16
Thankam S Nair, Pavan K Kommareddi, Maria M Galano, Danielle M Miller, Bala Naveen Kakaraparthi, Steven A Telian, H Alex Arts, Hussam El-Kashlan, Alyse Kilijanczyk, Amy Anne D Lassig, Martin P Graham, Susan G Fisher, Stefan W Stoll, Rajan P Nair, James T Elder, Thomas E Carey
SLC44A2 was discovered as the target of an antibody that causes hearing loss. Knockout mice develop age related hearing loss, loss of sensory cells and spiral ganglion neurons. SLC44A2 has polymorphic sites implicated in human disease. Transfusion related acute lung injury (TRALI) is linked to rs2288904 and genome wide association studies link rs2288904 and rs9797861 to venous thromboembolism (VTE), coronary artery disease and stroke. Here we report linkage disequilibrium of rs2288904 with rs3087969 and the association of these SLC44A2 SNPs with Meniere's disease severity...
November 6, 2016: Genomics
https://www.readbyqxmd.com/read/27822199/clinical-subgroups-in-bilateral-meniere-disease
#17
Lidia Frejo, Andres Soto-Varela, Sofía Santos-Perez, Ismael Aran, Angel Batuecas-Caletrio, Vanesa Perez-Guillen, Herminio Perez-Garrigues, Jesus Fraile, Eduardo Martin-Sanz, Maria C Tapia, Gabriel Trinidad, Ana María García-Arumi, Rocío González-Aguado, Juan M Espinosa-Sanchez, Pedro Marques, Paz Perez, Jesus Benitez, Jose A Lopez-Escamez
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27812817/translabyrinthine-vestibular-neurectomy-and-simultaneous-cochlear-implant-for-m%C3%A3-ni%C3%A3-re-s-disease
#18
Pietro Canzi, Marco Manfrin, Marco Perotti, Federico Aprile, Silvia Quaglieri, Elisabetta Rebecchi, Giulia Locatelli, Marco Benazzo
BACKGROUND: Surgical management of Ménière's disease (MD) is recommended in case of medical and intratympanic treatment failures. Translabyrinthine vestibular nerve section has been considered the gold standard for denervation procedures in order to control vertigo attacks, although at the cost of sacrificing residual hearing. To the best of our knowledge, no work has been published with regard to a group of patients submitted to translabyrinthine vestibular neurectomy and simultaneous cochlear implant for MD...
November 4, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27804084/ion-transport-its-regulation-in-the-endolymphatic-sac-suggestions-for-clinical-aspects-of-meniere-s-disease
#19
REVIEW
Nozomu Mori, Takenori Miyashita, Ryuhei Inamoto, Ai Matsubara, Terushige Mori, Kosuke Akiyama, Hiroshi Hoshikawa
Ion transport and its regulation in the endolymphatic sac (ES) are reviewed on the basis of recent lines of evidence. The morphological and physiological findings demonstrate that epithelial cells in the intermediate portion of the ES are more functional in ion transport than those in the other portions. Several ion channels, ion transporters, ion exchangers, and so on have been reported to be present in epithelial cells of ES intermediate portion. An imaging study has shown that mitochondria-rich cells in the ES intermediate portion have a higher activity of Na(+), K(+)-ATPase and a higher Na(+) permeability than other type of cells, implying that molecules related to Na(+) transport, such as epithelial sodium channel (ENaC), Na(+)-K(+)-2Cl(-) cotransporter 2 (NKCC2) and thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC), may be present in mitochondria-rich cells...
November 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27783138/cochlear-implantation-in-patients-with-definite-meniere-s-disease
#20
Nils Kristian Prenzler, Eva Bültmann, Alexandros Giourgas, Melanie Steffens, Rolf Benedikt Salcher, Stefan Stolle, Anke Lesinski-Schiedat, Thomas Lenarz, Martin Durisin
The exact pathomechanism of deafening in Meniere's disease (MD) is still unknown; intoxication of hair cells and neural damage from endolymphatic hydrops is discussed. In the literature, there are only a few reports on hearing outcome of MD patients after treatment with cochlear implantation (CI) whereby especially the comparison of MD vs. non-MD patients with CI differs. In this retrospective study, results in speech understanding [Freiburger Einsilber (FES65) and Hochmair-Schulz-Moser test in quiet (HSM) and in noise (HSM + 10 dB)] of 27 implanted MD patients were collected and compared to a matched standard CI cohort...
October 25, 2016: European Archives of Oto-rhino-laryngology
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