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https://www.readbyqxmd.com/read/28818391/role-of-capillary-pericytes-and-precapillary-arterioles-in-the-vascular-mechanism-of-betahistine-in-a-guinea-pig-inner-ear-model
#1
Mattis Bertlich, Friedrich Ihler, Bernhard G Weiss, Saskia Freytag, Michael Strupp, Mark Jakob, Martin Canis
AIMS: Betahistine is a histamine analogue that is used for the treatment of Menière's disease. Animal studies showed that it increases local blood flow in the stria vascularis. In terms of its mode of action, recent studies have prompted discussion of whether betahistine actively affects cochlear microcirculation by dilations of pericytes or of precapillary arterioles or by mere downstream effects. Hence, we investigated the effects of betahistine on cochlear capillary pericytes and precapillary arterioles...
August 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28811849/meniere-s-disease-and-vestibular-migraine-updates-and-review-of-the-literature
#2
REVIEW
Paul Tabet, Issam Saliba
The diagnosis of Meniere's disease (MD) and vestibular migraine (VM) is primarily based on clinical criteria and their differentiation is often difficult. Currently, there are no known definitive diagnostic tests that can reliably distinguish the two conditions. Patients with MD and patients with VM are treated differently, therefore improving the diagnosis of these two pathologies should avoid errors in management. A systematic review was conducted according to PRISMA guidelines. Medline-Ovid and Embase databases were used to conduct a thorough search of English-language publications dating from 1948 to March 2016...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28774486/histopathology-of-tympanic-membranes-from-patients-with-ventilation-tubes
#3
Mehmet Faruk Oktay, Hasan Deniz Tansuker, Hisaki Fukushima, Michael M Paparella, Patricia A Schachern, Sebahattin Cureoglu
OBJECTIVE: To evaluate the histopathologic changes in tympanic membranes (TMs) with ventilation tubes (VTs). METHODS: In this retrospective human temporal bone study our overall study group included 4 subgroups of TMs from deceased donors as follows: 24 with a history of VT insertion for chronic otitis media with effusion (COME-VT); 5 with a history of VT insertion for Meniere's disease (MD-VT); 33 without a history of VT insertion for chronic otitis media with effusion (COME); and 14 without a history of VT insertion for Meniere's disease (MD)...
July 31, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28770282/-diagnostic-criteria-for-meni%C3%A3-re-s-disease-according-to-the-classification-committee-of-the-b%C3%A3-r%C3%A3-ny-society
#4
REVIEW
J A Lopez-Escamez, J Carey, W-H Chung, J A Goebel, M Magnusson, M Mandalà, D E Newman-Toker, M Strupp, M Suzuki, F Trabalzini, A Bisdorff
This paper presents diagnostic criteria for Menière's disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. The classification includes two categories: definite Menière's disease and probable Menière's disease. The diagnosis of definite Menière's disease is based on clinical criteria and requires the observation of an episodic vertigo syndrome associated with low- to medium-frequency sensorineural hearing loss and fluctuating aural symptoms (hearing, tinnitus and/or fullness) in the affected ear...
August 2, 2017: HNO
https://www.readbyqxmd.com/read/28769744/the-auditory-nerve-overlapped-waveform-anow-detects-small-endolymphatic-manipulations-that-may-go-undetected-by-conventional-measurements
#5
Jeffery T Lichtenhan, Choongheon Lee, Farah Dubaybo, Kaitlyn A Wenrich, Uzma S Wilson
Electrocochleography (ECochG) has been used to assess Ménière's disease, a pathology associated with endolymphatic hydrops and low-frequency sensorineural hearing loss. However, the current ECochG techniques are limited for use at high-frequencies only (≥1 kHz) and cannot be used to assess and understand the low-frequency sensorineural hearing loss in ears with Ménière's disease. In the current study, we use a relatively new ECochG technique to make measurements that originate from afferent auditory nerve fibers in the apical half of the cochlear spiral to assess effects of endolymphatic hydrops in guinea pig ears...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28762301/in-reference-to-a-new-theory-for-m%C3%A3-ni%C3%A3-re-s-disease
#6
John Stuart Phillips, Peter R Prinsley
No abstract text is available yet for this article.
August 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28760618/control-of-vertigo-in-m%C3%A3-ni%C3%A3-re-s-disease-by-intratympanic-dexamethasone
#7
A Weckel, M Marx, M-J Esteve-Fraysse
OBJECTIVE: The main objective was to assess the efficacy of intratympanic dexamethasone injection in controlling vertigo in unilateral Ménière's disease refractory to medical treatment. MATERIALS AND METHODS: A retrospective study included 25 patients with disabling unilateral Ménière's disease, defined according to the American Academy of Otorhinolaryngology-Head and Neck Surgery (AAO-HNS) criteria. Patients received intratympanic dexamethasone during the monitoring period...
July 28, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28760332/evidence-of-surgical-treatments-for-intractable-meniere-s-disease
#8
REVIEW
Tadashi Kitahara
Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. In this review article, we would like to demonstrate the evidences for surgical treatments according to the previous papers, and consider the next therapeutic strategies including surgical options according to the international guidelines...
July 28, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28749204/revision-of-a-furosemide-loading-vestibular-evoked-myogenic-potential-protocol-for-detecting-endolymphatic-hydrops
#9
Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Katsumi Doi
OBJECTIVE: The presence of endolymphatic hydrops can be suggested by improving the amplitude of vestibular-evoked myogenic potential (VEMP) after furosemide administration (furosemide loading VEMP [FVEMP]). The authors aimed to determine a stimulation frequency and judgment criteria to ascertain whether a revised FVEMP protocol can be applied to clinical settings. METHODS: The study included 25 individuals with unilateral Meniere's disease (MD) and 11 normal healthy volunteers...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28744995/idiopathic-sudden-sensorineural-hearing-loss-and-m%C3%A3-ni%C3%A3-re-syndrome-the-role-of-cerebral-venous-drainage
#10
Marco Matteo Ciccone, Pietro Scicchitano, Michele Gesualdo, Francesca Cortese, Annapaola Zito, Fabio Manca, Barbara Boninfante, Pasquale Recchia, Domenico Leogrande, Domenico Viola, Marialessia Damiani, Valeria Gambacorta, Antonio Piccolo, Vincenzo De Ceglie, Nicola Quaranta
AIM: to evaluate the influence of cerebral venous drainage on the pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) and Ménière syndrome (MD). METHODS: we enrolled 59 consecutive patients (32 males, mean age 53.05+15.37 years): 40 ISSHL and 19 MD. All underwent physical examination, biochemical evaluation (glycemic and lipid profile, viral serology, C reactive protein, etc), audiometric (tonal, vocal, vestibular evoked myogenic potentials and auditory brainstem response test) and impedentiometric examination...
July 26, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28742261/the-clinical-characteristics-and-audiogram-in-103-meniere-disease-patients-with-and-without-vestibular-migraine
#11
Yixu Wang, Tongxiang Diao, Yixin Zhao, Lisheng Yu
1 There was a close relationship between MD and VM. 48 MD patients(46.6%) had VM, 18 MD patients (17.5%)were probable to have VM. 2 MD patients with VM have better hearing than those without VM at 500 Hz, 1000Hz, and 2000Hz. 3 Among MD patients with VM, the mean monthly frequency of vertigo attack was 7.1,which can differ significantly from those among MD patients with probable VM and those without VM.(P<0.01). 4 The female MD patients were 7.92 times to have VM than male MD patients(95% CI, 2.97 to 21.08; P=0...
July 25, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28741403/comparative-study-between-the-caloric-vestibular-and-the-video-head-impulse-tests-in-unilateral-meni%C3%A3-re-s-disease
#12
Jonathan Andrés Cordero-Yanza, Edna Verónica Arrieta Vázquez, Juan Carlos Hernaiz Leonardo, Jimena Mancera Sánchez, Mario Sabas Hernández Palestina, Nicolás Pérez-Fernández
OBJECTIVE: Compare the caloric vestibular test (CVT) and the video head impulse test (vHIT) in the evaluation of Meniere's disease (MD) and to analyze their diagnostic accuracy. MATERIALS AND METHODS: Retrospective review of CVT and vHIT performed in MD patients at a tertiary care referral center in Spain. RESULTS: A total of 88 patients were reviewed. The CVT was abnormal in 67% (n = 59) of patients, while the vHIT was abnormal in 66% (n = 58) of them...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28739195/dizziness-symptom-type-prevalence-and-overlap-a-us-nationally-representative-survey
#13
Kevin A Kerber, Brian C Callaghan, Steven A Telian, William J Meurer, Lesli E Skolarus, Wendy Carender, James F Burke
BACKGROUND: The traditional approach to dizziness encourages providers to emphasize the type of dizziness. However, symptom types might substantially overlap in individual patients, thus limiting the clinical value of this approach. We aimed to describe the overlap of types of dizziness using a United States nationally representative sample. METHODS: The 2008 US National Health Interview Survey was examined for prevalence and overlap of types of dizziness. The data was also separately examined among people who otherwise had typical features of traditionally vertigo-based disorders (i...
July 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28730350/-on-the-diagnosis-of-meni%C3%A3-re-s-disease-discussion-of-the-new-criteria
#14
R Gürkov
No abstract text is available yet for this article.
July 20, 2017: HNO
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#15
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
July 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28723597/short-term-results-of-intra-tympanic-gentamicin-and-dexamethasone-on-hearing-and-tinnitus-in-meniere-s-disease-a-case-control-study
#16
Irfan Ul Shamas
INTRODUCTION: The role of this study was to evaluate the effectiveness of intra tympanic administration of Gentamicin(40 mgs/ml) and Dexamethasone 0.5 ml(4 mgs/ml) on hearing and tinnitus of patients who had recurrent acute attacks of vertigo, tinnitus and hearing loss. STUDY DESIGN: 60 consecutive patients of Meniere's disease were randomly divided into 3 groups of twenty patients each. Group A included 20 patients who received intra tympanic gentamicin, Group B included 20 patients who received intra tympanic dexamethasone and Group C included 20 patients who received intra tympanic normal saline 0...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28719825/degeneration-of-the-vestibular-nerve-in-unilateral-meniere-s-disease-evaluated-by-galvanic-vestibular-evoked-myogenic-potentials
#17
Chih-Ming Chang, Yi-Ho Young, Fu-Shan Jaw, Chi-Te Wang, Po-Wen Cheng
OBJECTIVE: The staging system of Meniere's disease utilizes audiograms to probe cochlear dysfunction. We explored the addition of galvanic vestibular-evoked myogenic potentials (VEMP) to further explore vestibular function. METHODS: Seventy patients with unilateral Meniere's disease were enrolled in this study. Within 2weeks of diagnosis, all subjects underwent pure tone audiometry, cervical and ocular VEMP, and caloric test. The prevalence of abnormal tests and the VEMP characteristic parameters such as latencies and amplitudes were analyzed...
September 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28716762/selective-window-application-of-gentamicin-dexamethasone-in-meniere-s-disease
#18
Fazıl Necdet Ardıç, Funda Tümkaya, Kamil Aykal, Burçin Çabuk
OBJECTIVE: The purpose of the study is to prevent hearing loss when using intratympanic (IT) gentamicin for intractable Meniere's disease. MATERIALS AND METHODS: It is a retrospective case review study. Twenty five patients who had definite Meniere's disease and had either selective window application or weekly IT gentamicin were included into the study. First group (selective) had dexamethasone on the round window and gentamicin on oval window during exploratory tympanotomy procedure...
July 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28708796/significance-of-endolymphatic-hydrops-in-ears-with-unilateral-sensorineural-hearing-loss
#19
Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone
OBJECTIVE: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases. STUDY DESIGN: Retrospective study. SETTING: University hospital. METHODS: One hundred eighty-two ears from 91 patients with unilateral SNHL were studied...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28704892/is-electrocochleography-still-helpful-in-early-diagnosis-of-meniere-disease
#20
Fulvio Mammarella, Melissa Zelli, Theodoros Varakliotis, Alberto Eibenstein, Claudio Maria Pianura, Gianluca Bellocchi
BACKGROUND AND OBJECTIVES: Despite the extensive research for the Meniere's disease (MD), it's pathophysiology still remains uncertain and questionable among scientists. Clinical symptoms and audiometric tests form the basis for the diagnosis. Nevertheless the differential diagnosis can be extremely challenging, due to subjective and not specific results. Incorrect diagnosis is most likely and for this reason there is a great demand for objective and reliable tests. SUBJECTS AND METHODS: The presence of endolymphatic hydrops is necessary condition but non enough for the diagnosis...
July 2017: Journal of Audiology & Otology
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