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https://www.readbyqxmd.com/read/29231089/erratum
#1
(no author information available yet)
Lambert PR, Silverstein H, LeBel C, Bishop K. OTO-104 in Ménière's disease patients: phase 3 results. Otolaryngol Head Neck Surg. 2017;157:P122-P123. (Original doi: 10.1177/0194599817717251f) This Oral Presentation abstract should have included a note indicating that it was withdrawn during production of the issue. The online version has been updated to include this note.
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29227452/high-resolution-three-dimensional-delayed-contrast-mri-detects-endolymphatic-hydrops-in-patients-with-vertigo-and-vestibular-schwannoma
#2
Roxana Moayer, Gail P Ishiyama, Stellios Karnezis, Ali R Sepahdari, Akira Ishiyama
OBJECTIVE: Advances in high resolution magnetic resonance imaging (MRI) have enabled the detection of endolymphatic hydrops (EH), a pathological ballooning of the endolymphatic fluid system, known to be associated with Menière's disease. When a patient has a known diagnosis of vestibular schwannoma and develops recurrent episodic vertigo spells, many surgeons recommend surgical intervention, attributing the vestibular symptoms to the vestibular schwannoma. The aim of this study is to evaluate the clinical outcome in patients with vestibular schwannoma and EH, treated medically, for recurrent spells of vertigo...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29209435/diseases-potentially-related-to-flammer-syndrome
#3
REVIEW
Katarzyna Konieczka, Carl Erb
Flammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber's hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29194211/publishing-trends-in-otology-and-neurotology
#4
Ryan Boerner, Jonathan L Hatch, Elizabeth Harruff, Shaun A Nguyen, Habib G Rizk, Ted A Meyer, Paul R Lambert, Theodore R McRackan
OBJECTIVES: 1) Describe publishing trends for otologic/neurotologic disorders over a 35-year span. 2) Compare trends in publishing with disease prevalence. 3) Evaluate changes in topic and journal specific ranking scores over time. METHODS: PubMed searches were performed on 35 otologic/neurotologic disorders using medical subject headings (MeSH) terms from 1980 to 2015. Searches were limited in scope to the English language. A Mann-Kendall trend analysis evaluated changes in publication frequency as a discrete variable while correcting for total number of articles published per year...
November 29, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29190572/increased-prevalence-and-risk-of-anxiety-disorders-in-adults-with-tinnitus-a-population-based-study-in-taiwan
#5
Ching-En Lin, Li-Fen Chen, Po-Han Chou, Chi-Hsiang Chung
OBJECTIVE: Tinnitus is a common disorder that may cause psychological distress and anxiety. The aim of this study was to investigate the association between anxiety disorders (ADs) and tinnitus in a large population. METHOD: We conducted a cross-sectional study using the National Health Insurance Research Database in Taiwan. Study subjects included 14,772 patients with tinnitus and 709,963 people in the general population who sought treatment in 2005. Distributions in ADs, age, sex, and medical comorbidities were compared between groups using chi-squared tests...
November 16, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29190293/morphological-correlation-between-caloric-tests-and-vestibular-hydrops-in-m%C3%A3-ni%C3%A3-re-s-disease-using-intravenous-gd-enhanced-inner-ear-mri
#6
Ji Eun Choi, Yi-Kyung Kim, Young Sang Cho, Kieun Lee, Hyun Woo Park, Sung Hoon Yoon, Hyung-Jin Kim, Won-Ho Chung
The purpose of this study was to prove the hypothesis that caloric response in Ménière's disease (MD) is reduced by hydropic expansion of the vestibular labyrinth, not by vestibular hypofunction, by evaluating the correlation morphologically using an intravenous Gadolinium (IV-Gd) inner ear MRI. In study I, the prevalence of abnormal video Head Impulse Test (vHIT) results among the patients with definite unilateral MD (n = 24) and vestibular neuritis (VN) (n = 22) were investigated. All patients showed abnormal canal paresis (CP) (> 26%) on caloric tests...
2017: PloS One
https://www.readbyqxmd.com/read/29164594/rna-sequencing-study-of-peripheral-blood-mononuclear-cells-in-sporadic-meniere-s-disease-patients-possible-contribution-of-immunologic-dysfunction-to-the-development-of-this-disorder
#7
Ying Sun, Daogong Zhang, Gaoying Sun, Yafeng Lv, Yawei Li, Xiaofei Li, Yongdong Song, Jianfeng Li, Zhaomin Fan, Haibo Wang
To date, the pathogenesis of Meniere's disease (MD) remains unclear. This study aims to investigate the possible relationship between potential immune system related genes and sporadic Meniere's disease. The whole RNA-sequencing (RNA-seq) technology was used to analyze the transcriptome of peripheral blood mononuclear cells of 3 MD patients and 3 control individuals. Of 366 differentially expressed genes (DEGs), 154 genes were up-regulated and 212 genes were down-regulated (|log2Foldchange| >1 and p <0...
November 22, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29138539/patient-reported-benefits-from-patient-organization-magazines-and-internet-based-peer-support-in-m%C3%A3-ni%C3%A3-re-s-disease
#8
Vinaya Manchaiah, Ilmari Pyykkö, Jing Zou, Hilla Levo, Erna Kentala
Objectives: To facilitate self-help, the Finnish Ménière's Federation (FMF) provides various kinds of support to persons with Ménière's disease (MD), which includes patient magazines (PM) and Internet-based peer support (iPS). The current study aimed to evaluate the benefits reported by MD patients in terms of PM and iPS. Method: The study used a cross-sectional survey design with a mixture of structured and open-ended questions administered online. A sample of 185 patients from the FMF membership database provided complete data...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29135874/meni%C3%A3-re-and-friends-imaging-and-classification-of-hydropic-ear-disease
#9
Robert Gürkov
BACKGROUND: Over 75 years ago, endolymphatic hydrops was discovered as the pathologic correlate of Menière's disease. However, this pathologic finding could be ascertained only in postmortem histologic studies. Due to this diagnostic dilemma and the variable manifestation of the various audiovestibular symptoms, diagnostic classification systems based on clinical findings have been used hitherto. METHODS: A review of the literature of magnetic resonance (MR) imaging of hydropic ear disease...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29135871/ocular-vestibular-evoked-myogenic-potentials-where-are-we-now
#10
Julia Dlugaiczyk
OBJECTIVE: Over the last decade, ocular vestibular evoked myogenic potentials (oVEMPs) have evolved as a new clinical test for dynamic otolith (predominantly utricular) function. The aim of this review is to give an update on the neurophysiological foundations of oVEMPs and their implications for recording and interpreting oVEMP responses in clinical practice. CONCLUSION: Different lines of anatomical, neurophysiological, and clinical evidence support the notion that oVEMPs measure predominantly contralateral utricular function, while cervical cVEMPs are an indicator of ipsilateral saccular function...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29105767/the-relationship-between-endolymphatic-hydrops-in-the-vestibule-and-low-frequency-air-bone-gaps
#11
Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Yuriko Okazaki, Shinji Naganawa, Michihiko Sone
OBJECTIVES/HYPOTHESIS: To investigate the relationship between endolymphatic hydrops and hearing level, focusing on significant vestibular endolymphatic hydrops adjacent to the stapes footplate and low-frequency air-bone gaps. STUDY DESIGN: Retrospective study. METHODS: The study included 1,548 ears from 775 patients who underwent magnetic resonance imaging examination in our university hospital to investigate possible endolymphatic hydrops between January 2012 and December 2015...
November 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29099816/is-betahistine-effective-for-m%C3%A3-ni%C3%A3-re%C3%A2-s-disease
#12
Andrés Rosenbaum, Matías Winter
PROBLEM: Meniere’s disease is an inner ear disorder characterized by episodes of spontaneous vertigo, fluctuating hearing loss and tinnitus. Betahistine has been used to reduce intensity and frecuency of vertigo attacks, but there is controversy regarding its effectiveness. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
October 31, 2017: Medwave
https://www.readbyqxmd.com/read/29099441/mastoid-and-inner-ear-measurements-in-patients-with-meni%C3%A3-re-s-disease
#13
Eric M Sugihara, Alexander L Marinica, Nathan D Vandjelovic, Benjamin M Kelley, Said S Sana, Nicholas E Starkey, Seilesh C Babu
OBJECTIVE: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls. STUDY DESIGN: Retrospective chart review. SETTING: Two tertiary referral centers. PATIENTS: Adults older than 18 years with Menière's disease treated with endolymphatic sac decompression (ESD) or medical management (non-ESD) versus controls...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29098343/-the-new-meni%C3%A3-re-s-disease-classification-under-discussion
#14
EDITORIAL
S Plontke
No abstract text is available yet for this article.
November 2017: HNO
https://www.readbyqxmd.com/read/29095749/genetics-of-vestibular-syndromes
#15
Pablo Roman-Naranjo, Alvaro Gallego-Martinez, Jose A Lopez Escamez
PURPOSE OF REVIEW: The increased availability of next generation sequencing has enabled a rapid progress in the discovery of genetic variants associated with vestibular disorders. We have summarized molecular genetics finding in vestibular syndromes during the last 18 months. RECENT FINDINGS: Genetic studies continue to shed light on the genetic background of vestibular disorders. Novel genes affecting brain development and otolith biogenesis have been associated with motion sickness...
November 1, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29095392/the-differential-diagnosis-of-vertigo-in-children-a-systematic-review-of-2726-cases
#16
Meghan Davitt, Michael T Delvecchio, Stephen C Aronoff
OBJECTIVES: Vertigo is a relatively common complaint in children with 5.3% of pediatric patients complaining of this symptom. Although the causes of vertigo have been well established in adults, the diagnoses in children have not been well described. The aims of this systematic review are to discover the current information regarding etiologies of vertigo in children and to determine the most common diagnoses that present with vertigo in pediatric patients. METHODS: PubMed, Scopus, and Embase were searched using the PRISMA guidelines...
October 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29093067/practice-guideline-cervical-and-ocular-vestibular-evoked-myogenic-potential-testing-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#17
Terry D Fife, James G Colebatch, Kevin A Kerber, Krister Brantberg, Michael Strupp, Hyung Lee, Mark F Walker, Eric Ashman, Jeffrey Fletcher, Brian Callaghan, David S Gloss
OBJECTIVE: To systematically review the evidence and make recommendations with regard to diagnostic utility of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively). Four questions were asked: Does cVEMP accurately identify superior canal dehiscence syndrome (SCDS)? Does oVEMP accurately identify SCDS? For suspected vestibular symptoms, does cVEMP/oVEMP accurately identify vestibular dysfunction related to the saccule/utricle? For vestibular symptoms, does cVEMP/oVEMP accurately and substantively aid diagnosis of any specific vestibular disorder besides SCDS? METHODS: The guideline panel identified and classified relevant published studies (January 1980-December 2016) according to the 2004 American Academy of Neurology process...
November 1, 2017: Neurology
https://www.readbyqxmd.com/read/29092804/bilateral-vestibular-hypofunction-in-quantitative-head-impulse-test-clinical-characteristics-in-23-patients
#18
Hilla Levo, Heikki Aalto, Timo P Hirvonen
OBJECTIVE: To explore clinical features of patients with bilateral vestibular hypofunction (BVH) verified in motorized head impulse test (MHIT). MATERIALS AND METHODS: We examined clinical records of 23 adult patients (10 males and 13 females), whose gain of the vestibulo-ocular reflex in the MHIT was bilaterally lowered. Fifteen of 62 unilateral cochlear implant (CI) recipients routinely tested both pre- and postoperatively with the MHIT had BVH. Eight of 198 vestibular outpatients selected to the MHIT due to clinical causes had BVH...
November 2, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29082086/elhnet-a-convolutional-neural-network-for-classifying-cochlear-endolymphatic-hydrops-imaged-with-optical-coherence-tomography
#19
George S Liu, Michael H Zhu, Jinkyung Kim, Patrick Raphael, Brian E Applegate, John S Oghalai
Detection of endolymphatic hydrops is important for diagnosing Meniere's disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the image pixels and observer-determined labels of endolymphatic hydrops as the inputs...
October 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29081426/bilateral-vestibulopathy-diagnostic-criteria-consensus-document-of-the-classification-committee-of-the-b%C3%A3-r%C3%A3-ny-society
#20
Michael Strupp, Ji-Soo Kim, Toshihisa Murofushi, Dominik Straumann, Joanna C Jen, Sally M Rosengren, Charles C Della Santina, Herman Kingma
This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia...
2017: Journal of Vestibular Research: Equilibrium & Orientation
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