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New anticogulants

Xiaobei Zheng, Juan Li, Zhengwang Chen, Yimei Liu, Keli Chen
BACKGROUND: Dried Whitmania pigra is used for the treatment of cardiovascular and cerebrovascular diseases in traditional Chinese medicine and hot water and alcohol extracts also have anticogulant activity. However, a lower molecular weight and more stable anticogulant is needed. OBJECTIVE: The objective of the following study is to purify and characterize of an anticoagulant oligopeptide from Hirudo (Whitmania pigra Whitman). MATERIALS AND METHODS: Gel filtration on Sephadex G-50, ion exchange on diethylaminoethyl-cellulose, and semi-prepared high-performance liquid chromatography were used to purify Hirudo...
July 2015: Pharmacognosy Magazine
Shannon Cope, Andreas Clemens, Florence Hammès, Herbert Noack, Jeroen P Jansen
OBJECTIVES: To critically appraise published network meta-analyses (NMAs) evaluating the efficacy or safety of the new oral anticogulants (NOACs) dabigatran, rivaroxaban, and apixaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (AF). METHODS: A systematic literature review was performed to identify the relevant NMAs using MEDLINE, EMBASE, Cochrane Library, Database of Abstracts of Reviews of Effects, and Health Technology Assessment...
March 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Fernando Veiga Fernández, María del Rocío Malfeito Jiménez, Sonia María Barros Cerviño, María del Mar Magariños Losada
Anticoagulation in elderly people with non-valvular atrial afibrillation (AF) is a challenge, due to the thromboembolic, as well as the haemorrhagic risks. The correct use of anticoagulants in these patients has shown a higher net clinical benefit when comparing it with a younger population. Non-vitamin K antagonist oral anticoagulants (NOACs) have been compared to oral vitamin K antagonists in several studies that included a sufficient number of elderly people. Favourable results for non-vitamin K antagonist oral anticoagulants were obtained in these studies, making them the preferred treatment for this group of patients...
May 2015: Revista Española de Geriatría y Gerontología
Domenico Di Raimondo, Antonino Tuttolomondo, Carmelo Buttà, Benedetto Lucifora, Giuseppe Licata, Antonio Pinto
Among the different subtypes of ischaemic strokes, almost 20 % are of cardiac origin. Different are the causes of cardioembolic stroke, but the most common is the atrial fibrillation, a supraventricular arrhythmia. Appropriate use of antiplatelet drugs and anticoagulants after transient ischaemic attack (TIA) or ischaemic stroke depends on whether the underlying cause is cardioembolic or of presumed arterial origin. Adequate antiplatelet therapy is recommended for secondary prevention after cerebral ischaemia of presumed arterial origin, whether for patients with TIA and ischaemic stroke of cardiac origin, mainly due to atrial fibrillation...
November 2013: Current Vascular Pharmacology
D L Cull, J R Wheeler, R T Gregory, S O Synder, R G Gayle, F N Parent
Expanded indications for caval interruption and earlier diagnosis of deep venous thrombosis have resulted in increased use of transvenous caval interruption devices and have intensified the search for the ideal caval filter. The Vena Tech vena cava filter is a percutaneous, transvenous caval interruption device which was recently introduced in the United States. We reviewed our experience with this filter. During the period of September 1989 to July 1990, 41 patients underwent placement of the Vena Tech filter...
September 1991: Journal of Cardiovascular Surgery
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