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https://www.readbyqxmd.com/read/29241243/core-components-for-a-clinically-integrated-mhealth-app-for-asthma-symptom-monitoring
#1
Robert S Rudin, Christopher H Fanta, Zachary Predmore, Kevin Kron, Maria O Edelen, Adam B Landman, Eyal Zimlichman, David W Bates
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29240990/wnt-signaling-loss-accelerates-the-appearance-of-neuropathological-hallmarks-of-alzheimer-s-disease-in-j20-app-transgenic-and-wild-type-mice
#2
Cheril Tapia-Rojas, Nibaldo C Inestrosa
Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotective factor against Aβ toxicity and tau phosphorylation. However, dysfunction of Wnt/β-catenin signaling might also play a role in the onset and development of the disease. J20 APPswInd transgenic (Tg) mouse model of AD was treated i...
December 14, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29240723/identi%C3%AF-cation-of-key-genes-and-pathways-in-tongue-squamous-cell-carcinoma-using-bioinformatics-analysis
#3
Huayong Zhang, Jianmin Liu, Xiaoyan Fu, Ankui Yang
BACKGROUND Tongue squamous cell carcinoma (TSCC) is a major type of oral cancers and has remained an intractable cancer over the past decades. The aim of this study was to identify differentially expressed genes (DEGs) during TSCC and reveal their potential mechanisms. MATERIAL AND METHODS The gene expression profiles of GSE13601 were downloaded from the GEO database. The GSE13601 dataset contains 57 samples, including 31 tongue SCC samples and 26 matched normal mucosa samples. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed; Cytoscape software was used for the protein-protein interaction (PPI) network and module analysis of the DEGs...
December 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29239334/calycosin-improves-cognitive-function-in-a-transgenic-mouse-model-of-alzheimer-s-disease-by-activating-the-protein-kinase-c-pathway
#4
Lei Song, Xiaoping Li, Xiao-Xue Bai, Jian Gao, Chun-Yan Wang
The major pathological changes in Alzheimer's disease are beta amyloid deposits and cognitive impairment. Calycosin is a typical phytoestrogen derived from radix astragali that binds to estrogen receptors to produce estrogen-like effects. Radix astragali Calycosin has been shown to relieve cognitive impairment induced by diabetes mellitus, suggesting calycosin may improve the cognitive function of Alzheimer's disease patients. The protein kinase C pathway is upstream of the mitogen-activated protein kinase pathway and exerts a neuroprotective effect by regulating Alzheimer's disease-related beta amyloid degradation...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29238873/insights-into-the-generation-of-monoclonal-antibody-acidic-charge-variants-during-chinese-hamster-ovary-cell-cultures
#5
Hongping Tang, Shiwei Miao, Xintao Zhang, Li Fan, Xuping Liu, Wen-Song Tan, Liang Zhao
Charge variation is one of the most important heterogeneities during monoclonal antibody (mAb) manufacturing and this study presents insights into the generation of acidic charge variants during cell culture processes. Since acidic variants generate both intracellularly and extracellularly, main charge fraction collected by weak cation exchange chromatography (WCX) was incubated in harvested cell supernatant (HCS) to simulate and investigate the extracellular process firstly. It is found that the main fraction was degraded rapidly into acidic variants rather than basic variants extracellularly, and the degradation sites were located in both Fab and Fc fragments indicated by papain digestion...
December 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29238422/electronic-questionnaires-design-and-implementation
#6
REVIEW
Clara Minto, Giulia Beltrame Vriz, Matteo Martinato, Dario Gregori
Background: Nursing and health care research are increasingly using e-questionnaires and e-forms for data collection and survey conduction. The main reason lies in costs, time and data-entry errors containment, increased flexibility, functionality and usability. In spite of this growing usage, no specifc and comprehensive guidelines for designing and submitting e-questionnaires have been produced so far. Objective: The aim of this review is to collect information on the current best practices, taking them from various fields of application...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/29238310/parameter-based-evaluation-of-attentional-impairments-in-schizophrenia-and-their-modulation-by-prefrontal-transcranial-direct-current-stimulation
#7
Nadine Gögler, Irina Papazova, Tatiana Oviedo-Salcedo, Nina Filipova, Wolfgang Strube, Johanna Funk, Hermann J Müller, Kathrin Finke, Alkomiet Hasan
Background: Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods: In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bundesen's Theory of Visual Attention (TVA) to (i) identify specific visual attentional parameters affected in schizophrenia and (ii) assess, as a proof of concept, the potential of single-dose anodal transcranial direct current stimulation (tDCS; 20 min, 2 mA) to the left dorsolateral prefrontal cortex to modulate these attentional parameters...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29238290/intermittent-fasting-protects-against-alzheimer-s-disease-possible-through-restoring-aquaporin-4-polarity
#8
Jingzhu Zhang, Zhipeng Zhan, Xinhui Li, Aiping Xing, Congmin Jiang, Yanqiu Chen, Wanying Shi, Li An
The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer's disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by the ratio of two AQP4 isoforms M1 and M23 (AQP4-M1/M23), however, it is unknown whether the ratio of AQP4-M1/M23 changes in AD. Histone deacetylase 3 has been reported to be significantly increased in AD brain. Moreover, evidence indicated that microRNA-130a (miR-130a) possibly mediates the regulation of histone deacetylase 3 on AQP4-M1/M23 ratio by repressing the transcriptional activity of AQP4-M1 in AD...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29238071/app-upregulation-contributes-to-retinal-ganglion-cell-degeneration-via-jnk3
#9
Chao Liu, Cheng-Wu Zhang, Yi Zhou, Wan Qing Wong, Liying Corinne Lee, Wei Yi Ong, Sung Ok Yoon, Wanjin Hong, Xin-Yuan Fu, Tuck Wah Soong, Edward H Koo, Lawrence W Stanton, Kah-Leong Lim, Zhi-Cheng Xiao, Gavin S Dawe
Axonal injury is a common feature of central nervous system insults. Upregulation of amyloid precursor protein (APP) is observed following central nervous system neurotrauma and is regarded as a marker of central nervous system axonal injury. However, the underlying mechanism by which APP mediates neuronal death remains to be elucidated. Here, we used mouse optic nerve axotomy (ONA) to model central nervous system axonal injury replicating aspects of retinal ganglion cell (RGC) death in optic neuropathies. APP and APP intracellular domain (AICD) were upregulated in retina after ONA and APP knockout reduced Tuj1+ RGC loss...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29237927/distinct-rab7-related-endosomal-autophagic-lysosomal-dysregulation-observed-in-cortex-and-hippocampus-in-appswe-psen1de9-mouse-model-of-alzheimer-s-disease
#10
Li Ba, Xiao-Hua Chen, Yan-Lin Chen, Qing Nie, Zhi-Jun Li, Feng-Fei Ding, Min Zhang
BACKGROUND: Amyloid-β deposition and accumulation of autophagic vacuoles are pathologic features of Alzheimer's disease (AD). Dysregulation of the endosomal-autophagic-lysosomal (EAL) pathway, which impairs amyloid precursor protein processing, is one of the earliest changes in AD. However, the precise role of EAL pathway in neurodegeneration remains unclear. This study aimed to investigate the role of EAL pathway in AD and further study the mechanism of EAL dysfunction. METHODS: We used 3-, 7-, and 12-month-old APPswe/PSEN1dE9 (APP/PS1) mice to model different stages of AD with age- and gender-matched wild-type littermates as controls (4-7 mice per group) and detected the changes of EAL markers, endosomal organizers Rab5 and Rab7, autophagosome marker LC3B, and lysosomal proteins Lamp1/2 in cortex and hippocampus by immunohistochemistry and Western blotting analysis...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29236078/an-artificial-neural-network-for-movement-pattern-analysis-to-estimate-blood-alcohol-content-level
#11
Pedram Gharani, Brian Suffoletto, Tammy Chung, Hassan A Karimi
Impairments in gait occur after alcohol consumption, and, if detected in real-time, could guide the delivery of "just-in-time" injury prevention interventions. We aimed to identify the salient features of gait that could be used for estimating blood alcohol content (BAC) level in a typical drinking environment. We recruited 10 young adults with a history of heavy drinking to test our research app. During four consecutive Fridays and Saturdays, every hour from 8 p.m. to 12 a.m., they were prompted to use the app to report alcohol consumption and complete a 5-step straight-line walking task, during which 3-axis acceleration and angular velocity data was sampled at a frequency of 100 Hz...
December 13, 2017: Sensors
https://www.readbyqxmd.com/read/29234436/fraction-n-butanol-of-radix-notoginseng-protects-pc12-cells-from-a%C3%AE-25-35-induced-cytotoxicity-and-alleviates-cognitive-deficits-in-samp8-mice-by-attenuating-oxidative-stress-and-a%C3%AE-accumulation
#12
Jin-Lan Huang, Ying-Qin Feng, Li-Ru Bai, Mei-Chun Qin, Zhe-Hao Xu, Zhao-Rong Liu, Wen-Bing Chen, Deng-Pan Wu, Zhen-Guo Zhong
Chinese medicine has been used for Alzheimer's disease (AD) treatment for thousands of years with more effective and fewer side effects. Therefore, developing effective potential candidates from Chinese medicine against AD would be considered as critical and efficient therapy for AD treatment. This study was designed to evaluate the neuronal protective effect of fraction n-butanol (NB) of Radix Notoginseng on Aβ25-35-induced PC12 cells, explore the effect of the tested fraction on spatial learning and memory, and characterize the impacts of fraction NB on antioxidant enzymes, Aβ production, and APP and BACE1 expressions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233854/efficacy-of-educational-video-game-versus-traditional-educational-apps-at-improving-physician-decision-making-in-trauma-triage-randomized-controlled-trial
#13
Deepika Mohan, Coreen Farris, Baruch Fischhoff, Matthew R Rosengart, Derek C Angus, Donald M Yealy, David J Wallace, Amber E Barnato
OBJECTIVE: To determine whether a behavioral intervention delivered through a video game can improve the appropriateness of trauma triage decisions in the emergency department of non-trauma centers. DESIGN: Randomized clinical trial. SETTING: Online intervention in national sample of emergency medicine physicians who make triage decisions at US hospitals. PARTICIPANTS: 368 emergency medicine physicians primarily working at non-trauma centers...
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29233806/mobile-health-technology-mdiab-for-the-prevention-of-type-2-diabetes-protocol-for-a-randomized-controlled-trial
#14
Shruti Muralidharan, Viswanathan Mohan, Ranjit Mohan Anjana, Sidhant Jena, Nikhil Tandon, Steven Allender, Harish Ranjani
BACKGROUND: The prevalence of type 2 diabetes is increasing in epidemic proportions in low- and middle-income countries. There is an urgent need for novel methods to tackle the increasing incidence of diabetes. The ubiquity of mobile phone use and access to Internet makes mobile health (mHealth) technology a viable tool to prevent and manage diabetes. OBJECTIVE: The objective of this randomized controlled trial is to implement and evaluate the feasibility, cost-effectiveness, and sustainability of a reality television-based lifestyle intervention program...
December 12, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29233803/a-smartphone-app-to-reduce-sugar-sweetened-beverage-consumption-among-young-adults-in-australian-remote-indigenous-communities-design-formative-evaluation-and-user-testing
#15
Emma Tonkin, Lauren Jeffs, Thomas Philip Wycherley, Carol Maher, Ross Smith, Jonathon Hart, Beau Cubillo, Julie Brimblecombe
BACKGROUND: The disproportionate burden of noncommunicable disease among Indigenous Australians living in remote Indigenous communities (RICs) is a complex and persistent problem. Smartphones are increasingly being used by young Indigenous adults and therefore represent a promising method to engage them in programs seeking to improve nutritional intake. OBJECTIVE: This study aimed to consult RIC members to inform the content of a smartphone app that can be used to monitor and reduce sugar-sweetened beverage intake in RICs...
December 12, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29233669/using-voice-to-create-hospital-progress-notes-description-of-a-mobile-application-and-supporting-system-integrated-with-a-commercial-electronic-health-record
#16
Thomas H Payne, W David Alonso, J Andrew Markiel, Kevin Lybarger, Andrew A White
We describe the development and design of a smartphone app-based system to create inpatient progress notes using voice, commercial automatic speech recognition software, with text processing to recognize spoken voice commands and format the note, and integration with a commercial EHR. This new system fits hospital rounding workflow and was used to support a randomized clinical trial testing whether use of voice to create notes improves timeliness of note availability, note quality, and physician satisfaction with the note creation process...
December 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29233567/obtaining-continuous-brac-bac-estimates-in-the-field-a-hybrid-system-integrating-transdermal-alcohol-biosensor-intellidrink-smartphone-app-and-brac-estimator-software-tools
#17
Susan E Luczak, Ashley L Hawkins, Zheng Dai, Raphael Wichmann, Chunming Wang, I Gary Rosen
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously...
December 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29233432/design-and-activity-evaluation-of-an-advanced-introductory-pharmacy-practice-experience-aippe-course-for-assessment-of-student-appe-readiness
#18
Eric Gilliam, Wesley Nuffer, Megan Thompson, Joseph Vande Griend
BACKGROUND AND PURPOSE: The newly implemented Advanced-Introductory Pharmacy Practice Experience (aIPPE) course at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences was designed to assess student readiness for Advanced Pharmacy Practice Experience (APPE) and provide formative feedback regarding skills and abilities needed to be successful during subsequent coursework and practice experiences. EDUCATIONAL ACTIVITY AND SETTING: The aIPPE is a full-time, six week (240hours) direct patient care rotation occurring in the spring semester of the third-professional year following a longitudinal integrated IPPE program...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233431/development-and-delivery-of-an-interdisciplinary-course-in-mobile-health-mhealth
#19
Brent I Fox, David A Umphress, Joshua C Hollingsworth
BACKGROUND: Interdisciplinary practice is a primary focus within the United States health care system. Despite the existence of interdisciplinary educational efforts in pharmacy for many years, the practice only recently entered mainstream health care education. Informatics offers interdisciplinary educational opportunities. Mobile health (mHealth), an informatics sub-discipline, is the use of mobile devices for health and wellness activities. We used the mHealth domain as the context for an interdisciplinary learning experience for pharmacy and computer science and software engineering (CSSE) students...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233429/pharmacy-students-perceptions-of-the-usefulness-of-motivational-interviewing-and-the-use-of-mobile-health-applications-on-patient-counseling-in-the-future
#20
Justin K Owensby, Jan Kavookjian
INTRODUCTION: To explore student pharmacists' perceptions of 1) future patient counseling, 2) use of mobile health applications (mHealth apps), and 3) usefulness of motivational interviewing (MI) in patient encounters and potential app messaging. METHODS: A cross-sectional design with first and second year pharmacy students (n=315) at a multi-campus university after exposure to mHealth app and MI curricular content. A questionnaire assessed perceptions of 1) future patient counseling, 2) using apps for personal use and professional encounters, and 3) potential practicality and usefulness of MI principles/skills in apps messaging...
July 2017: Currents in Pharmacy Teaching & Learning
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