keyword
MENU ▼
Read by QxMD icon Read
search

Apps

keyword
https://www.readbyqxmd.com/read/29036903/resveratrol-and-amyloid-beta-mechanistic-insights
#1
REVIEW
Yongming Jia, Na Wang, Xuewei Liu
The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer's disease (AD) has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production and clearance of Aβ. There is emerging evidence that resveratrol (Res), a naturally occurring polyphenol mainly found in grapes and red wine, acts on AD in numerous in vivo and in vitro models...
October 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29036636/genetic-reduction-of-nrf2-exacerbates-cognitive-deficits-in-a-mouse-model-of-alzheimer-s-disease
#2
Caterina Branca, Eric Ferreira, Thuy-Vi Nguyen, Kristian Doyle, Antonella Caccamo, Salvatore Oddo
Aging is the major risk factor for several neurodegenerative diseases, including Alzheimer's disease (AD). However, the mechanisms by which aging contributes to neurodegeneration remain elusive. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor that regulates expression of a vast number of genes by binding to the antioxidant response element. Nrf2 levels decrease as a function of age, and reduced Nrf2 levels have been reported in postmortem human brains and animal models of AD...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036546/crocoblast-running-blast-efficiently-in-the-age-of-next-generation-sequencing
#3
Ravi José Tristão Ramos, Allan Cézar de Azevedo Martins, Gabrielle da Silva Delgado, Crina-Maria Ionescu, Turán Peter Ürményi, Rosane Silva, Jaroslav Koca
Summary: CrocoBLAST is a tool for dramatically speeding up BLAST+ execution on any computer. Alignments that would take days or weeks with NCBI BLAST+ can be run overnight with CrocoBLAST. Additionally, CrocoBLAST provides features critical for NGS data analysis, including: results identical to those of BLAST+; compatibility with any BLAST+ version; real-time information regarding calculation progress and remaining run time; access to partial alignment results; queueing, pausing, and resuming BLAST+ calculations without information loss...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036531/spatkin-a-simulator-for-rule-based-modeling-of-biomolecular-site-dynamics-on-surfaces
#4
Marek Kochanczyk, William S Hlavacek, Tomasz Lipniacki
Summary: Rule-based modeling is a powerful approach for studying biomolecular site dynamics. Here, we present SPATKIN, a general-purpose simulator for rule-based modeling in two spatial dimensions. The simulation algorithm is a lattice-based method that tracks Brownian motion of individual molecules and the stochastic firing of rule-defined reaction events. Because rules are used as event generators, the algorithm is network-free, meaning that it does not require to generate the complete reaction network implied by rules prior to simulation...
July 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036513/scangeo-parallel-mining-of-high-throughput-gene-expression-data
#5
Katja Koeppen, Bruce A Stanton, Thomas H Hampton
Summary: Current options to mine publicly available gene expression data deposited in NCBI's gene expression omnibus (GEO), such as the GEO web portal and related applications, are optimized to reanalyze a single study, or search for a single gene, and therefore require manual intervention to reanalyze multiple studies for user-specified gene sets. ScanGEO is a simple, user-friendly Shiny web application designed to identify differentially expressed genes across all GEO studies matching user-specified criteria, for a flexible set of genes, visualize results and provide summary statistics and other reports using a single command...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035677/effectiveness-of-a-smartphone-application-for-the-management-of-metabolic-syndrome-components-focusing-on-weight-loss-a-preliminary-study
#6
Tatiana Toro-Ramos, Dong-Hwa Lee, Youngin Kim, Andreas Michaelides, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Soo Lim
BACKGROUND: There are inconsistent results for the effectiveness of using smartphone applications (apps) or websites on weight loss. We investigated the efficacy of a smartphone intervention using a designated app that utilizes a lifestyle intervention-focused approach, including a human coaching element, toward weight loss in overweight or obese Korean adults. METHODS: One hundred four adults aged 20-60 years with a body mass index ≥23 kg/m(2), who signed up for a smartphone program for weight loss (using the Noom app), were recruited...
October 16, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29035624/nurses-perceptions-and-problems-in-the-usability-of-a-medication-safety-app
#7
Kalyani Ankem, Sookyung Cho, Diana Simpson
INTRODUCTION: The majority of medication apps support medication adherence. Equally, if not more important, is medication safety. Few apps report on medication safety, and fewer studies have been conducted with these apps. OBJECTIVES: The usability of a medication safety app was tested with nurses to reveal their perceptions of the graphical user interface and to discover problems they encountered in using the app. METHODS: Usability testing of the app was conducted with RN-BSN students and informatics students (n = 18)...
October 16, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/29034545/a-pilot-intervention-to-reduce-postpartum-weight-retention-and-central-adiposity-in-first-time-mothers-results-from-the-mums-online-online-lifestyle-nutrition-exercise-study
#8
P van der Pligt, K Ball, K D Hesketh, M Teychenne, D Crawford, P J Morgan, C E Collins, K J Campbell
BACKGROUND: Postpartum weight retention (PPWR) increases the risk for obesity and complications during subsequent pregnancies. Few interventions have been successful in limiting PPWR in mothers. The present study assessed the effectiveness of the mums OnLiNE (Online, Lifestyle, Nutrition & Exercise) intervention with respect to reducing PPWR and improving diet, physical activity and sedentary behaviour. METHODS: A subsample of first-time mothers enrolled in the Extended Melbourne Infant Feeding Activity and Nutrition Trial (InFANT Extend) completed the nonrandomised mums OnLiNE intervention...
October 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29032705/a-mobile-application-for-monitoring-and-management-of-depressed-mood-in-a-vulnerable-pregnant-population
#9
Liisa Hantsoo, Stephanie Criniti, Annum Khan, Marian Moseley, Naomi Kincler, Laura J Faherty, C Neill Epperson, Ian M Bennett
OBJECTIVE: This study tested whether a mood tracking and alert (MTA) mobile application (app) improved mental health care delivery in a high-risk obstetric population. METHODS: Pregnant women with depressive symptomatology at <32 weeks gestation were followed for eight weeks after randomization to a control patient portal (PP) app alone or with the MTA app. The MTA app monitored activity, assessed mood, and alerted obstetric providers of signs of worsening mood...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29032190/transient-increase-in-sapp%C3%AE-secretion-in-response-to-a%C3%AE-1-42-oligomers-an-attempt-of-neuronal-self-defense
#10
Christiane Rose, Emilie Dorard, Mickael Audrain, Lucie Gorisse-Hussonnois, Nathalie Cartier, Jérome Braudeau, Bernadette Allinquant
Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers modulate the formation and secretion of sAPPα is not known. We report here that the addition of Aβ1-42 oligomers to primary cortical neurons induced a transient increase in α-secretase activity and secreted sAPPα 6-9 hours later...
September 19, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29032184/exploring-young-adult-perspectives-on-the-use-of-gamification-and-social-media-in-a-smartphone-platform-for-improving-vegetable-intake
#11
Monica Marina Nour, Anika Saiyara Rouf, Margaret Allman-Farinelli
Young adults are the poorest consumers of vegetables. Social media and smartphones are frequently used by this demographic and could serve as an engaging medium for nutrition promotion. Five focus groups were conducted to capture participants' perceptions of a theory-based gamified self-monitoring app for improving vegetable intake of young adults. Ranking activities were used to gather feedback on preferences for social media posts. Data arising from group discussion were analysed using NVivo software using a deductive approach to group common ideas into themes...
October 11, 2017: Appetite
https://www.readbyqxmd.com/read/29031834/dysregulation-of-neurotrophin-signaling-in-the-pathogenesis-of-alzheimer-disease-and-of-alzheimer-disease-in-down-syndrome
#12
REVIEW
Xu-Qiao Chen, Mariko Sawa, William C Mobley
Neurotrophic factors, including the members of the neurotrophin family, play important roles in the development and maintenance of the nervous system. Trophic factor signals must be transmitted over long distances from axons and dendrites to the cell bodies of neurons. A mode of signaling well suited to the challenge of robust long distance signaling is the signaling endosome. We review the biology of signaling endosomes and the "signaling endosome hypothesis". Evidence for disruption of signaling endosome function in disorders of the nervous system is also reviewed...
October 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29031581/parent-perceptions-of-mobile-device-use-among%C3%A2-preschool-aged-children-in-rural-head%C3%A2-start-centers
#13
Morgan McCloskey, Susan L Johnson, Cristen Benz, Darcy A Thompson, Barbara Chamberlin, Lauren Clark, Laura L Bellows
OBJECTIVE: To describe child use and parents' beliefs and comfort with young children's use of mobile devices in low-income, rural communities. METHODS: This was a descriptive, cross-sectional study. The survey, which consisted of 18 multiple-part questions, was distributed to families at 5 Head Start/preschool centers in Colorado. RESULTS: In total, 192 surveys were returned (28.5% response rate). Most children (92%) used a smartphone or tablet at some frequency and most parents (90%) had downloaded apps specifically for their child...
October 11, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29030503/a-qualitative-study-of-a-blended-therapy-using-problem-solving-therapy-with-a-customised-smartphone-app-in-men-who-present-to-hospital-with-intentional-self-harm
#14
Craig Mackie, Nicole Dunn, Sarah MacLean, Valerie Testa, Marnin Heisel, Simon Hatcher
BACKGROUND: Blended therapy describes the use of computerised therapy combined with face-to-face therapy to extend the depth, range and nature of the face-to-face therapy. We wanted to develop a treatment manual for a randomised trial of blended therapy combining face-to-face problem solving and a smartphone app in men who present to hospital with self-harm. OBJECTIVE: To develop a treatment manual and to describe the experience of receiving and delivering a blended therapy...
October 13, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29030325/adhd-is-there-an-app-for-that-a-suitability-assessment-of-apps-for-the-parents-of-children-and-young-people-with-adhd
#15
Lauren Powell, Jack Parker, Valerie Harpin
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is a highly comorbid disorder that can impact significantly on the individual and their family. ADHD is managed via pharmacological and nonpharmacological interventions. Parents also gain support from parent support groups, which may include chat rooms, as well as face-to-face meetings. With the growth of technology use over recent years, parents have access to more resources that ever before. A number of mobile apps have been developed to help parents manage ADHD in their children and young people...
October 13, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29030160/mobile-application-vs-paper-pictorial-blood-assessment-chart-to-track-menses-in-young-women-a-randomized-cross-over-design
#16
Amanda E Jacobson, Sara K Vesely, Fareeda Haamid, Myra Christian-Rancy, Sarah H O'Brien
BACKGROUND: /Objectives: Heavy menstrual bleeding is a common complaint reported by approximately 30% of women. The Pictorial Blood Assessment Chart (PBAC) score is often used to quantify severity of menstrual bleeding. However, the traditional PBAC paper diary may be subject to recall bias and compliance issues, especially in adolescents. We developed a mobile application (app) version of the PBAC score and evaluated patient satisfaction and compliance with app reporting vs paper reporting...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29029666/exercising-with-veterans-how-social-interaction-with-a-pharmacy-student-improves-patient-care
#17
Genna Holder, Brent Salvig
With the baby boomer population anticipated to explode between 2010 and 2030, it is essential that student pharmacists learn how to properly care for older patients. One way for pharmacy students to prepare for providing health care to the elderly is to partake in an Advanced Pharmacy Practice Experience (APPE) elective course in geriatrics. Pharmacy students, and health care professionals in general, have an immense amount of information available to them that is not found in a patient's chart or textbook, but can be uncovered through increased social interaction with patients, promoting the best possible care...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29029478/effects-of-exercise-on-capillaries-in-the-white-matter-of-transgenic-ad-mice
#18
Yi Zhang, Feng-Lei Chao, Chun-Ni Zhou, Lin Jiang, Lei Zhang, Lin-Mu Chen, Yan-Min Luo, Qian Xiao, Yong Tang
Previous studies have shown that exercise can prevent white matter atrophy in APP/PS1 transgenic Alzheimer's disease (AD) mice. However, the mechanism of this protective effect remains unknown. To further understand this issue, we investigated the effects of exercise on the blood supply of white matter in transgenic AD mice. Six-month-old male APP/PS1 mice were randomly divided into a control group and a running group, and age-matched non-transgenic littermates were used as a wild-type control group. Mice in the running group ran on a treadmill at low intensity for four months...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029055/prognostic-models-for-9-month-mortality-in-tuberculous-meningitis
#19
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
Background: Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. We developed and validated prognostic models for 9-month mortality in HIV-uninfected and HIV-infected adults with TBM. Methods: We included 1699 subjects from four randomized clinical trials and one prospective observational study conducted at two major referral hospitals in Southern Vietnam from 2001-2015. Modelling was based on multivariable Cox proportional hazards regression...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028877/rinspector-a-cytoscape-app-for-centrality-analyses-and-dynamine-flexibility-prediction
#20
Guillaume Brysbaert, Kevin Lorgouilloux, Wim Vranken, Marc F Lensink
Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments...
September 22, 2017: Bioinformatics
keyword
keyword
3734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"