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https://www.readbyqxmd.com/read/27905242/constant-therapy
#1
(no author information available yet)
Designed by scientists at Boston University, the aim of this therapy app is to improve everyday speech, memory and focus skills in people recovering from traumatic brain injury, or who have aphasia, dementia or a speech-language disorder.
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27905226/unison-launches-app-to-help-nurses-raise-concerns-about-patient-safety-and-staffing
#2
(no author information available yet)
Unison Scotland has launched a free app for nurses to raise concerns about patient care using their smartphones or tablets.
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27904493/beta-2-adrenergic-receptor-activation-enhances-neurogenesis-in-alzheimer-s-disease-mice
#3
Gao-Shang Chai, Yang-Yang Wang, Amina Yasheng, Peng Zhao
Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β2-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β2-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27904476/impairment-of-the-nerve-growth-factor-pathway-driving-amyloid-accumulation-in-cholinergic-neurons-the-incipit-of-the-alzheimer-s-disease-story
#4
REVIEW
Viviana Triaca, Pietro Calissano
The current idea behind brain pathology is that disease is initiated by mild disturbances of common physiological processes. Overtime, the disruption of the neuronal homeostasis will determine irreversible degeneration and neuronal apoptosis. This could be also true in the case of nerve growth factor (NGF) alterations in sporadic Alzheimer's disease (AD), an age-related pathology characterized by cholinergic loss, amyloid plaques and neurofibrillary tangles. In fact, the pathway activated by NGF, a key neurotrophin for the metabolism of basal forebrain cholinergic neurons (BFCN), is one of the first homeostatic systems affected in prodromal AD...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903234/acute-phase-proteins-and-their-potential-role-as-an-indicator-for-fish-health-and-in-diagnosis-of-fish-diseases
#5
Suvra Roy, Vikash Kumar, Vikas Kumar, B K Behera
The acute phase proteins are biochemically and functionally unrelated protein predominantly synthesized in the liver. The local inflammatory cells i.e. macrophages and neutrophils secretes various cytokines like IL-1, IL-6, IL-8 (interleukins) and TNF-α into bloodstream in response to injury and tissue damage, which stimulate hepatocytes to produce protein and release them into the circulation; these proteins are called as acute phase protein (e.g. C-reactive protein (CRP), serum amyloid A (SAA), metal binding protein, lysozyme, lectin, etc...
November 21, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27903120/molecular-pathology-of-adamantinomatous-craniopharyngioma-review-and-opportunities-for-practice
#6
John Richard Apps, Juan Pedro Martinez-Barbera
Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma (ACP), much has been learned about the molecular pathways and processes that are disrupted in ACP pathogenesis. To date this understanding has not translated into tangible patient benefit. The recent development of novel techniques and a range of preclinical models now provides an opportunity to begin to support treatment decisions and develop new therapeutics based on molecular pathology. In this review the authors summarize many of the key findings and pathways implicated in ACP pathogenesis and discuss the challenges that need to be tackled to translate these basic science findings for the benefit of patients...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27902765/loss-of-cathepsin-b-and-l-leads-to-lysosomal-dysfunction-npc-like-cholesterol-sequestration-and-accumulation-of-the-key-alzheimer-s-proteins
#7
Stjepko Cermak, Marko Kosicek, Aleksandra Mladenovic-Djordjevic, Kosara Smiljanic, Selma Kanazir, Silva Hecimovic
Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the pathogenesis of numerous neurodegenerative diseases. In this work we analyzed how inhibition and/or loss of the major lysosomal proteases, the cysteine cathepsins B and L (CtsB/L), affects lysosomal function, cholesterol metabolism and degradation of the key Alzheimer's disease (AD) proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27900849/combined-use-of-a-wristband-and-a-smartphone-to-reduce-body-weight-in-obese-children-randomized-controlled-trial
#8
C Mameli, D Brunetti, V Colombo, G Bedogni, L Schneider, F Penagini, B Borsani, G V Zuccotti
BACKGROUND: Technological instruments may help control paediatric obesity. OBJECTIVE: We tested whether a personalized programme based on the energy expenditure obtained from a wristband (WB) and the energy intake obtained from a smartphone application (APP) is superior to a standard approach at promoting weight loss. METHODS: We performed a randomized controlled trial in obese children aged 10-17 years. The experimental (EXP) and control (CTR) groups were given a low-energy diet and a prescription for physical activity...
November 29, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27900343/divergence-and-rewiring-of-regulatory-networks-for-neural-development-between-human-and-other-species
#9
COMMENT
Ping Wang, Dejian Zhao, Shira Rockowitz, Deyou Zheng
Neural and brain development in human and other mammalian species are largely similar, but distinct features exist at the levels of macrostructure and underlying genetic control. Comparative studies of epigenetic regulation and transcription factor (TF) binding in humans, chimpanzees, rodents, and other species have found large differences in gene regulatory networks. A recent analysis of the cistromes of REST/NRSF, a critical transcriptional regulator for the nervous system, demonstrated that REST binding to syntenic genomic regions (i...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27899832/development-and-application-of-a-stepwise-assessment-process-for-rational-redesign-of-sequential-skills-based-courses
#10
Casey E Gallimore, Andrea L Porter, Susanne G Barnett
Objective. To develop and apply a stepwise process to assess achievement of course learning objectives related to advanced pharmacy practice experiences (APPEs) preparedness and inform redesign of sequential skills-based courses. Design. Four steps comprised the assessment and redesign process: (1) identify skills critical for APPE preparedness; (2) utilize focus groups and course evaluations to determine student competence in skill performance; (3) apply course mapping to identify course deficits contributing to suboptimal skill performance; and (4) initiate course redesign to target exposed deficits...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27899341/quality-of-mobile-phone-and-tablet-mobile-apps-for-speech-sound-disorders-protocol-for-an-evidence-based-appraisal
#11
Lisa M Furlong, Meg E Morris, Shane Erickson, Tanya A Serry
BACKGROUND: Although mobile apps are readily available for speech sound disorders (SSD), their validity has not been systematically evaluated. This evidence-based appraisal will critically review and synthesize current evidence on available therapy apps for use by children with SSD. OBJECTIVE: The main aims are to (1) identify the types of apps currently available for Android and iOS mobile phones and tablets, and (2) to critique their design features and content using a structured quality appraisal tool...
November 29, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27899340/ecological-momentary-assessment-of-adolescent-problems-coping-efficacy-and-mood-states-using-a-mobile-phone-app-an-exploratory-study
#12
Rachel Kenny, Barbara Dooley, Amanda Fitzgerald
BACKGROUND: Mobile technologies have the potential to be used as innovative tools for conducting research on the mental health and well-being of young people. In particular, they have utility for carrying out ecological momentary assessment (EMA) research by capturing data from participants in real time as they go about their daily lives. OBJECTIVE: The aim of this study was to explore the utility of a mobile phone app as a means of collecting EMA data pertaining to mood, problems, and coping efficacy in a school-based sample of Irish young people...
November 29, 2016: JMIR Mental Health
https://www.readbyqxmd.com/read/27899148/undereporting-of-acute-pesticide-poisoning-in-tanzania-modelling-results-from-two-cross-sectional-studies
#13
Elikana E Lekei, Aiwerasia V Ngowi, Leslie London
BACKGROUND: Acute pesticide poisoning (APP) is known to cause serious injuries to end users globally but the magnitude of this problem in Tanzania is not well known. This study aimed to determine the extent and pattern of underreporting of APP in Tanzania to inform the development of a surveillance system and appropriate interventions. METHODS: This study integrates findings from two recent Tanzanian studies. A household survey established the proportion of poisoned farmers in a typical rural area who reported to hospital for a pesticide poisoning...
November 29, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27898460/a-pilot-comparison-of-a-smartphone-app-with-or-without-2-way-messaging-among-chronic-pain-patients-who-benefits-from-a-pain-app
#14
Robert N Jamison, Dylan C Jurcik, Robert R Edwards, Chuan-Chin Huang, Edgar L Ross
OBJECTIVES: The overall aim of this study was to determine the effect of introducing a smartphone pain app, for both Android and iPhone devices that enables chronic pain patients to assess, monitor, and communicate their status to their providers. METHODS: This study recruited 105 chronic pain patients to use a smartphone pain app and half of the subjects (N=52) had 2-way messaging available through the app. All subjects completed baseline measures and were asked to record their progress every day for 3 months, with the opportunity to continue for 6 months...
November 24, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27898095/efficient-generation-of-orthologous-point-mutations-in-pigs-via-crispr-assisted-ssodn-mediated-homology-directed-repair
#15
Kankan Wang, Xiaochun Tang, Yan Liu, Zicong Xie, Xiaodong Zou, Mengjing Li, Hongming Yuan, Hongsheng Ouyang, Huping Jiao, Daxin Pang
Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate single-stranded oligonucleotides (ssODN) mediated knockin by introducing two orthologous pathogenic mutations, p.E693G for Alzheimer's disease and p.G2019S for Parkinson's disease, into porcine APP and LRRK2 loci, respectively...
November 29, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27898028/estimating-leaf-area-index-lai-in-vineyards-using-the-pocketlai-smart-app
#16
Francesca Orlando, Ermes Movedi, Davide Coduto, Simone Parisi, Lucio Brancadoro, Valentina Pagani, Tommaso Guarneri, Roberto Confalonieri
Estimating leaf area index (LAI) of Vitis vinifera using indirect methods involves some critical issues, related to its discontinuous and non-homogeneous canopy. This study evaluates the smart app PocketLAI and hemispherical photography in vineyards against destructive LAI measurements. Data were collected during six surveys in an experimental site characterized by a high level of heterogeneity among plants, allowing us to explore a wide range of LAI values. During the last survey, the possibility to combine remote sensing data and in-situ PocketLAI estimates (smart scouting) was evaluated...
November 26, 2016: Sensors
https://www.readbyqxmd.com/read/27897737/ashford-and-st-peter-s-breast-care
#17
(no author information available yet)
This app was developed by Ashford and St Peter's Hospitals to cover essential information on breast care patients in an accessible, non-overwhelming way.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27896984/methods-for-clustering-time-series-data-acquired-from-mobile-health-apps
#18
Nicole Tignor, Pei Wang, Nicholas Genes, Linda Rogers, Steven G Hershman, Erick R Scott, Micol Zweig, Yu-Feng Yvonne Chan, Eric E Schadt
In our recent Asthma Mobile Health Study (AMHS), thousands of asthma patients across the country contributed medical data through the iPhone Asthma Health App on a daily basis for an extended period of time. The collected data included daily self-reported asthma symptoms, symptom triggers, and real time geographic location information. The AMHS is just one of many studies occurring in the context of now many thousands of mobile health apps aimed at improving wellness and better managing chronic disease conditions, leveraging the passive and active collection of data from mobile, handheld smart devices...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896798/applicability-of-acceptance-and-commitment-therapy-based-mobile-app-in-depression-nursing
#19
Kirsikka Kaipainen, Pasi Välkkynen, Nina Kilkku
Due to the high burden of depression, new models and methods of mental healthcare need to be developed. Prior research has shown the potential benefits of using technology tools such as mobile apps as self-help or combined with psychological treatment. Therefore, professionals should acquaint themselves with evidence-based apps to be able to use them with clients and guide the clients in their use. The purpose of this study was to explore how an acceptance and commitment therapy-based mobile app was perceived as a self-management tool among nurses, and how it could be applied in the prevention and treatment of depression and other mental health issues...
November 28, 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27896780/development-of-a-user-friendly-app-for-assisting-anticoagulation-treatment
#20
Johannes Vegt
Blood coagulation time is an important factor to consider for postoperative and cardiac disorder patients who have been prescribed anticoagulant coagulant medications. This chapter describes a patient self-management system for assessment of blood coagulation times and determining appropriate anticoagulant dosages using a test strip device and the Coagu app. This app can also be used as a patient reminder of treatment times and to monitor treatment and effects over time.
2017: Methods in Molecular Biology
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