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https://www.readbyqxmd.com/read/28822725/berberine-modulates-amyloid-%C3%AE-peptide-generation-by-activating-amp-activated-protein-kinase
#1
Haijing Zhang, Chunhui Zhao, Guoqiong Cao, Limin Guo, Shuai Zhang, Yuexia Liang, Chunxia Qin, Ping Su, Hang Li, Wensheng Zhang
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory deficits and cognitive decline. Excessive amyloid-β (Aβ) peptide aggregates and forms soluble oligomers and insoluble cerebral amyloid plaques, which is widely thought to be the underlying pathogenic mechanism of AD. Therefore, effective regulation of Aβ metabolism is an important aspect of preventing and improving AD. Berberine, which is the main active component of the traditional medicinal herb Coptidis rhizoma, has a positive effect on reducing Aβ levels...
August 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28820754/sleep-apps-what-role-do-they-play-in-clinical-medicine
#2
Christopher P Lorenz, Adrian J Williams
PURPOSE OF REVIEW: Today's smartphones boast more computing power than the Apollo Guidance Computer. Given the ubiquity and popularity of smartphones, are we already carrying around miniaturized sleep labs in our pockets? RECENT FINDINGS: There is still a lack of validation studies for consumer sleep technologies in general and apps for monitoring sleep in particular. To overcome this gap, multidisciplinary teams are needed that focus on feasibility work at the intersection of software engineering, data science and clinical sleep medicine...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28819928/development-of-a-rating-tool-for-mobile-cancer-apps-information-analysis-and-formal-and-content-related-evaluation-of-selected-cancer-apps
#3
Cathleen Böhme, Marc Baron von Osthoff, Katrin Frey, Jutta Hübner
Mobile apps are offered in large numbers and have different qualities. The aim of this article was to develop a rating tool based on formal and content-related criteria for the assessment of cancer apps and to test its applicability on apps. After a thorough analysis of the literature, we developed a specific rating tool for cancer apps based on the MARS (mobile app rating system) and a rating tool for cancer websites. This instrument was applied to apps freely available in stores and focusing on some cancer topic...
August 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28819903/inhibition-of-pten-attenuates-endoplasmic-reticulum-stress-and-apoptosis-via-activation-of-pi3k-akt-pathway-in-alzheimer-s-disease
#4
Weigang Cui, Songtao Wang, Zhongping Wang, Zhiyong Wang, Chunli Sun, Yinghua Zhang
Amyloid plaques and neurofibrillary tangles are pathologic hallmarks of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress has been implicated in the loss of neurons in AD. The phosphatase and tensin homolog deleted on chromosome ten (PTEN) plays an important role in regulating neuronal survival processes. However, the direct effects of the PTEN on ER stress and apoptosis in AD have not been elucidated. In this study, we demonstrate that the expression of PTEN and ER stress related proteins, GRP78 and CHOP, increased in APP/PS1 transgenic AD mice compared with WT mice...
August 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28819649/prosocial-apathy-for-helping-others-when-effort-is-required
#5
Patricia L Lockwood, Mathilde Hamonet, Samuel H Zhang, Anya Ratnavel, Florentine U Salmony, Masud Husain, Matthew A J Apps
Prosocial acts - those that are costly to ourselves but benefit others - are a central component of human co-existence1-3. While the financial and moral costs of prosocial behaviours are well understood4-6, everyday prosocial acts do not typically come at such costs. Instead, they require effort. Here, using computational modelling of an effort-based task we show that people are prosocially apathetic. They are less willing to choose to initiate highly effortful acts that benefit others compared to benefitting themselves...
July 2017: Nature Human Behaviour
https://www.readbyqxmd.com/read/28818820/opportunities-of-mhealth-in-preconception-care-preferences-and-experiences-of-patients-and-health-care-providers-and-other-involved-professionals
#6
Matthijs R Van Dijk, Maria Ph Koster, Ageeth N Rosman, Regine Pm Steegers-Theunissen
BACKGROUND: The importance of the preconception period and preconception care (PCC) are broadly acknowledged and the potential benefits regarding health promotion have been studied extensively. PCC provides the opportunity to identify, prevent, and treat modifiable and nonmodifiable risk factors to optimize the health of couples trying to become pregnant. The prevalence of modifiable and nonmodifiable risk factors in these couples is high, but the uptake of PCC remains low. OBJECTIVE: The aim of this study is to identify the preferences and experiences of women and men (patients) trying to become pregnant and of health care providers and other involved professionals regarding mobile health (mHealth), in particular the coaching platform Smarter Pregnancy, and its potential role in PCC...
August 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28818819/quantifying-human-movement-using-the-movn-smartphone-app-validation-and-field-study
#7
Ralph Maddison, Luke Gemming, Javier Monedero, Linda Bolger, Sarahjane Belton, Johann Issartel, Samantha Marsh, Artur Direito, Madeleine Solenhill, Jinfeng Zhao, Daniel John Exeter, Harshvardhan Vathsangam, Jonathan Charles Rawstorn
BACKGROUND: The use of embedded smartphone sensors offers opportunities to measure physical activity (PA) and human movement. Big data-which includes billions of digital traces-offers scientists a new lens to examine PA in fine-grained detail and allows us to track people's geocoded movement patterns to determine their interaction with the environment. OBJECTIVE: The objective of this study was to examine the validity of the Movn smartphone app (Moving Analytics) for collecting PA and human movement data...
August 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28818818/validation-of-a-smartphone-based-approach-to-in-situ-cognitive-fatigue-assessment
#8
Edward Price, George Moore, Leo Galway, Mark Linden
BACKGROUND: Acquired Brain Injuries (ABIs) can result in multiple detrimental cognitive effects, such as reduced memory capability, concentration, and planning. These effects can lead to cognitive fatigue, which can exacerbate the symptoms of ABIs and hinder management and recovery. Assessing cognitive fatigue is difficult due to the largely subjective nature of the condition and existing assessment approaches. Traditional methods of assessment use self-assessment questionnaires delivered in a medical setting, but recent work has attempted to employ more objective cognitive tests as a way of evaluating cognitive fatigue...
August 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28817897/re-effect-of-home-monitoring-via-mobile-app-on-the-number-of-in-person-visits-following-ambulatory-surgery-a-randomized-clinical-trial
#9
David F Penson
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28817649/point-of-care-wound-visioning-technology-reproducibility-and-accuracy-of-a-wound-measurement-app
#10
Sheila C Wang, John A E Anderson, Robyn Evans, Kevin Woo, Benjamin Beland, Denis Sasseville, Linda Moreau
BACKGROUND: Current wound assessment practices are lacking on several measures. For example, the most common method for measuring wound size is using a ruler, which has been demonstrated to be crude and inaccurate. An increase in periwound temperature is a classic sign of infection but skin temperature is not always measured during wound assessments. To address this, we have developed a smartphone application that enables non-contact wound surface area and temperature measurements. Here we evaluate the inter-rater reliability and accuracy of this novel point-of-care wound assessment tool...
2017: PloS One
https://www.readbyqxmd.com/read/28817447/a-stress-coping-app-for-hospitalized-pregnant-women-at-risk-for-preterm-birth
#11
Nancy Jallo, Leroy R Thacker, Victoria Menzies, Predrag Stojanovic, Dace S Svikis
BACKGROUND: Pregnant women hospitalized with preterm labor (PTL) complications experience increased stress. Prior researchers have attempted to provide stress management strategies with use of various media players to deliver stress coping interventions. PURPOSE: The purpose of this study was to examine the efficacy of a mobile device delivered stress coping app designed to reduce stress in a sample of high-risk pregnant women hospitalized with complications of PTL...
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28816815/parent-education-is-changing-a-review-of-smartphone-apps
#12
(no author information available yet)
No abstract text is available yet for this article.
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28816805/development-of-a-mobile-app-for-family-planning-providers
#13
Viannella Halsall, Jennifer Rogers, Jacki Witt, Sejun Song, Hoang Duc Huy Nguyen, Patricia Kelly
PURPOSE: To provide an overview of lessons learned during the development process of an app for iOS and Android based on national recommendations for providing quality family planning services. STUDY AND DESIGN: After a review of existing apps was conducted to determine whether an app of clinical recommendations for family planning existed, a team of clinicians, training specialists, and app developers created a resource app by first drafting a comprehensive content map...
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28816804/smart-phone-apps-and-maternal-child-nursing
#14
(no author information available yet)
No abstract text is available yet for this article.
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28815510/inhibition-of-%C3%AE-secretase-leads-to-an-increase-in-presenilin-1
#15
Aitana Sogorb-Esteve, María-Salud García-Ayllón, Marta Llansola, Vicente Felipo, Kaj Blennow, Javier Sáez-Valero
γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment of SH-SY5Y cells with the GSI LY-374973 (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, DAPT) augments PS1, in parallel with increases in other γ-secretase subunits nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1, yet with no increase in messenger RNA expression...
August 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28815245/-experimental-study-on-osteogenesis-of-acellular-porcine-pericardium-in-guided-bone-regeneration
#16
Jun-Zhao Gao, Xue-Jian Zhang, Jia-Li Hou, Yue Deng, Yun-Peng Li
PURPOSE: To observe the retention time and effect of acellular porcine pericardium (APP) in bone regeneration for rabbit femoral bone defects. METHODS: APP was prepared as follows: fresh porcine pericardium was chosen, high and low osmotic NaCl solution were used to soak the specimen alternately, trypsin+EDTA were used for digest, and then immersed with TritonX-100, cross-linked by using glutaraldehyde. 24 New Zealand rabbits were selected, and the area of bone defect was created 8 mm×8 mm×5 mm in size on bilateral distal femur...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28815145/evolving-research-data-sharing-networks-to-clinical-app-sharing-networks
#17
Kavishwar B Wagholikar, Rahul Jain, Eliel Oliveira, Joshua Mandel, Jeffery Klann, Ricardo Colas, Prasad Patil, Kuladip Yadav, Kenneth D Mandl, Thomas Carton, Shawn N Murphy
Research networks for data sharing are growing into a large platform for pragmatic clinical trials to generate quality evidence for shared medical decision-making. Institutions partnering in the networks have made large investments in developing the infrastructure for sharing data. We investigate whether institutions partnering on Patient-Centered Outcomes Research Institute's (PCORI) network can share clinical apps. At two different sites, we imported patient data in PCORI's clinical data model (CDM) format into i2b2 repositories, and adapted the SMART-on-FHIR cell to perform CDM-to-FHIR translation, serving demographics, laboratory results and diagnoses...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814430/the-2017-eular-standardised-procedures-for-ultrasound-imaging-in-rheumatology
#18
Ingrid Möller, Iustina Janta, Marina Backhaus, Sarah Ohrndorf, David A Bong, Carlo Martinoli, Emilio Filippucci, Luca Maria Sconfienza, Lene Terslev, Nemanja Damjanov, Hilde Berner Hammer, Iwona Sudol-Szopinska, Walter Grassi, Peter Balint, George A W Bruyn, Maria Antonietta D'Agostino, Diana Hollander, Heidi J Siddle, Gabriela Supp, Wolfgang A Schmidt, Annamaria Iagnocco, Juhani Koski, David Kane, Daniela Fodor, Alessandra Bruns, Peter Mandl, Gurjit S Kaeley, Mihaela Micu, Carmen Ho, Violeta Vlad, Mario Chávez-López, Georgios Filippou, Carmen Elena Cerón, Rodina Nestorova, Maritza Quintero, Richard Wakefield, Loreto Carmona, Esperanza Naredo
BACKGROUND: In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an update of these guidelines. OBJECTIVES: To update the existing MSUS guidelines in rheumatology as well as to extend their scope to other anatomic structures relevant for rheumatology...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28814391/filling-the-void-a-role-for-exercise-induced-bdnf-and-brain-amyloid-precursor-protein-processing
#19
Rebecca Ek MacPherson
Inactivity, obesity, and insulin resistance are significant risk factors for the development of Alzheimer's disease (AD). Several studies have demonstrated that diet induced obesity, inactivity, and insulin resistance exacerbates neuropathological hallmarks of AD. The aggregation of beta-amyloid peptides is one of these hallmarks. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid precursor protein (APP) processing, leading to beta-amyloid peptide formation...
August 16, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28813630/gender-similarities-and-differences-for-e-health-behaviors-among-u-s-adults
#20
Cam Escoffery
BACKGROUND: Technology access and use are increasing worldwide. Adults can potentially use technology to assist with health promotion and medical care. INTRODUCTION: The purpose of this study was to compare the prevalence of participation in online health-related activities between different genders of U.S. adults aged 18-90 years. METHODS: Primary data collected through a survey panel were used to examine associations between gender and technology ownership, Internet health-seeking behaviors and online behaviors related to health, having an app, and preferences for health information...
August 16, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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