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Actinic keratosis laser

Jia Chen, Yunfeng Zhang, Peiru Wang, Bo Wang, Guolong Zhang, Xiuli Wang
BACKGROUND AND OBJECTIVES: Plum-blossom needling might enhance transdermal penetration of topically applied drugs by creating vertical channels. The purpose of this study was to evaluate drug delivery assisted by plum-blossom needling comparing with CO2 laser ablative fractional resurfacing (AFR) using 5-aminolevulinic acid (5-ALA), a porphyrin precursor, as a test drug. MATERIALS AND METHODS: Ex vivo porcine skin was treated with plum-blossom needle(HWATO, Suzhou medical supplies factory Co...
September 2016: Photodiagnosis and Photodynamic Therapy
Ayse Pelin Yigider, Fatma Tulin Kayhan, Ozgur Yigit, Ayse Kavak, Cemal Cingi
OBJECTIVES: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose. METHODS: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. RESULTS: Benign lesions of the nose include nonmalignant tumoral lesions (i...
May 2016: American Journal of Rhinology & Allergy
S Huth, Y Marquardt, P M Amann, M Leverkus, L Huth, P A Gerber, J M Baron
Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is a well-established treatment of actinic keratosis (AK) in field-cancerized skin (1). The underlying mechanism is a photoactivation of protoporphyrin IX (PpIX) when in presence of oxygen exposed to light of specific wavelengths (2, 3). This reaction produces reactive oxygen species (ROS), which are extremely aggressive inducing either autophagy or cellular necrosis as well as apoptosis in case of oxidative stress by thus far unknown mechanisms (4)...
May 19, 2016: Experimental Dermatology
Waseem Jerjes, Zaid Hamdoon, Ali A Abdulkareem, Colin Hopper
INTRODUCTION: Photodynamic therapy (PDT) is a minimally invasive intervention used in the management of tissue disorders. In this retrospective study, a total of 62 patients with actinic keratosis (AKs) were treated with surface illumination PDT. Comparisons with the clinical features, rate of recurrence as well as malignant transformation and overall outcome were made. MATERIALS AND METHODS: The medical records of 62 consecutive patients who presented with suspicious skin lesions and diagnosed with AKs were examined...
May 9, 2016: Photodiagnosis and Photodynamic Therapy
Douglas C Wu, Jeremy B Green
BACKGROUND: The aging arm is characterized by increased dyspigmentation, a proliferation of ectactic blood vessels, excessive adiposity, excessive skin laxity, and actinic keratosis. A variety of laser, energy, and surgical techniques can be used to improve these features. OBJECTIVE: The objective of this article is to describe the treatment modalities that have proven efficacious in rejuvenating the aging arm and combination therapies that have the potential to optimize patient outcomes while maintaining safety and tolerability...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
K Peris, P G Calzavara-Pinton, L Neri, G Girolomoni, G Malara, A Parodi, S Piaserico, R Rossi, G Pellacani
Actinic keratosis (AK) is a common skin disease which can potentially progress to invasive squamous cell carcinoma (iSCC). Given that mortality rates and health-care cost associated with iSCC are substantial, the management of AK represents an important public health issue. Several effective lesion-directed and field-directed treatments are available. Ablative procedures (e.g. cryosurgery, excision, laser ablation, curettage alone or with electrodessication) are considered cost-effective options for solitary lesions...
July 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Stephanie D Gan, Sarah H Hsu, Gary Chuang, Nellie Konnikov, Christine A Liang
No abstract text is available yet for this article.
February 2016: Journal of the American Academy of Dermatology
Anne Le Pillouer-Prost, Hugues Cartier
INTRODUCTION: Topical photodynamic therapy (PDT) is acknowledged to be a safe and efficient therapeutic option for the selective destruction of actinic keratosis and superficial carcinomas. Over the past 15 years, topical PDT has also been shown to be a possible method for "photorejuvenation." MATERIALS AND METHODS: An extensive review was performed of in vitro and in vivo (animals, organ transplant recipients, or immunocompetent patients) studies. RESULTS: The studies point to a high level of efficacy...
January 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Enrique Arciniegas, Luz Marina Carrillo, Héctor Rojas, Richard Ramírez, Oscar Reyes, Ambar Suárez, Fabiana Ortega
BACKGROUND: Actinic keratoses (AKs) are generally considered as premalignant skin lesions that can progress into squamous cell carcinoma (SCC) in situ and invasive SCC. However, its progression to SCC is still matter of debate. A transmembrane glycoprotein that contributes to the progression of certain premalignant and malignant lesions is mucin1 (MUC1). Nevertheless, their functions in the skin lesions are not yet fully clear. Therefore, the aim of this study is to ascertain whether MUC1 is present in the focal epidermal dysplasia of AK...
October 2015: Annals of Translational Medicine
C Cantisani, G Paolino, U Bottoni, S Calvieri
BACKGROUND: non-melanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized. Its incidence continues to grow at an alarming rate, becoming an occupational disease. Available treatments alternative to surgery include: photodynamic therapy, electrochemiotherapy, cryotherapy, ablative lasers, 5-fluorouracil, imiquimod, ingenol mebutate, and diclofenac. Each of these options has its advantages and disadvantages. Photodynamic therapy (PDT), using topically applied photosensitizer precursors such as methylaminolaevulinate (MAL), is a useful nonsurgical treatment, well accepted by patients, but the main limitation is pain...
November 2015: Journal of Drugs in Dermatology: JDD
Janneke P H M Kessels, Patty J Nelemans, Klara Mosterd, Nicole W J Kelleners-Smeets, Gertruud A M Krekels, Judith U Ostertag
Photodynamic therapy (PDT) with light emitting diode (LED) illumination is a frequently used treatment modality for actinic keratosis (AK) with excellent cosmetic outcome. A major disadvantage, however, is the high pain score. Pulsed dye laser (PDL) illumination has been suggested, but the long-term efficacy of this treatment is unknown. In this split-face study we prospectively treated 61 patients with AK, with both LED-PDT and PDL-PDT. The mean change in the number of lesions between the end of follow-up and start of therapy was -4...
March 2016: Acta Dermato-venereologica
L G Wiest, J Habig
Chemical peel treatments, which utilize a number of chemical peeling solutions subject to patient indication, are an easy to learn therapeutic technique suited for, in particular, various types of acne, acne scars, actinic keratosis and "sun-damaged skin". Especially the positive and long-lasting results of deep peels in the area of skin rejuvenation are deemed the gold standard against which other techniques, including lasers, must compare themselves. Other benefits of chemical peels include the flexibility to mix and match chemical solutions to custom design the treatment best suited for the desired degree of skin penetration, as well as the relatively low cost...
October 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Andrés M Erlendsson, Apostolos G Doukas, William A Farinelli, Brijesh Bhayana, R Rox Anderson, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Ablative fractional laser (AFXL) is rapidly evolving as one of the foremost techniques for cutaneous drug delivery. While AFXL has effectively improved topical drug-induced clearance rates of actinic keratosis, treatment of basal cell carcinomas (BCCs) has been challenging, potentially due to insufficient drug uptake in deeper skin layers. This study sought to investigate a standardized method to actively fill laser-generated channels by altering pressure, vacuum, and pressure (PVP), enquiring its effect on (i) relative filling of individual laser channels; (ii) cutaneous deposition and delivery kinetics; (iii) biodistribution and diffusion pattern, estimated by mathematical simulation...
February 2016: Lasers in Surgery and Medicine
Kirsi Isoherranen, Sari Koskenmies, Meri Overmark, Leea Ylitalo, Olli Saksela, Sari Pitkänen
Actinic keratoses are premalignant skin lesions with the risk of converting into squamous cell carcinoma, and therefore they should be treated. Treatment modalities include cryotherapy, photodynamic therapy, carbon dioxide laser and also topical treatments such as imiquimode, ingenol mebutate, 5-fluorouracil and diclophenac. In the future, the treatment of actinic keratosis can be more often done in primary health care. The most favorable treatment modality depends on patient age, general health, and the thickness, size and localization of the lesion...
2015: Duodecim; Lääketieteellinen Aikakauskirja
Priscila Ishioka, Marcus Maia, Sarita Bartholomei Rodrigues, Alessandra Cristina Marta, Sérgio Henrique Hirata
Topical treatment for actinic keratosis with 5% fluorouracil has a recurrence rate of 54% in 12 months of follow-up. This study analyzed thirteen actinic keratoses on the upper limbs through confocal microscopy, at the time of clinical diagnosis and after 4 weeks of treatment with fluorouracil. After the treatment was established and evidence of clinical cure was achieved, in two of the nine actinic keratoses, confocal microscopy enabled visualization of focal areas of atypical honeycomb pattern in the epidermis indicating therapeutic failure...
May 2015: Anais Brasileiros de Dermatologia
Meri Övermark, Sari Koskenmies, Sari Pitkänen
Squamous cell carcinoma in situ is an intra-epidermal malignancy of the skin with potential to progress to invasive carcinoma. Commonly used treatments are surgical excision, cryotherapy, photodynamic therapy, laser ablation, curettage with cautery, radiotherapy, topical 5-fluorouracil, and topical imiquimod. The efficacies of these different treatment modalities are compared in this retrospective study of 239 patients with squamous cell carcinoma in situ diagnosed and treated at our hospital during a period of one year...
January 2016: Acta Dermato-venereologica
Hyo Sang Song, Soo-Eun Jung, Yong Hyun Jang, Hee Young Kang, Eun-So Lee, You Chan Kim
BACKGROUND/PURPOSE: A relatively long incubation time is needed for photosensitizer absorption in conventional photodynamic therapy (PDT) for actinic keratosis (AK). The use of ablative CO2 fractional lasers (AFXLs) to increase drug delivery could shorten the incubation time. Here, we aimed to compare the efficacy between AFXL-assisted PDT with a short incubation time and conventional PDT for AK. METHODS: Patients with histopathologically confirmed facial AK were randomly divided into two groups...
November 2015: Photodermatology, Photoimmunology & Photomedicine
A M Erlendsson, E H Taudorf, A H Eriksson, C S Haak, J R Zibert, U Paasch, R R Anderson, M Haedersdal
Topically applied ingenol mebutate (IngMeb) is approved for field-treatment of actinic keratosis and is currently being investigated for treatment of non-melanoma skin cancer (NMSC). Ablative fractional lasers (AFXLs) generate microscopic ablation zones (MAZs) in the skin, which may help induce a deep penetration needed for effective treatment of NMSC. Using Franz diffusion cells, uptake and bio-distribution were investigated over 21 h in intact (n = 9) and AFXL-exposed porcine skin (n = 58). A 2940-nm fractional Er:YAG laser generated intraepidermal (11...
August 2015: Archives of Dermatological Research
Fabricio L Silveira, Marcos T T Pacheco, Benito Bodanese, Carlos A Pasqualucci, Renato A Zângaro, Landulfo Silveira
BACKGROUND AND OBJECTIVE: Raman spectroscopy was used to discriminate human non-melanoma skin lesions from non-tumor tissues in vivo. This work proposed the discrimination between non-melanoma (basal cell carcinoma, BCC; squamous cell carcinoma, SCC) and pre-cancerous lesions (actinic keratosis, AK) from benign lesions and normal (non-tumor group, NT) tissues, using near-infrared Raman spectroscopy with a Raman probe. MATERIALS AND METHODS: Prior to surgery, the spectra of suspicious lesions were obtained in situ...
January 2015: Lasers in Surgery and Medicine
Karin de Vries, Errol P Prens
Treatment of widespread actinic keratoses (AKs) and extensive photodamage is a challenge. One of the treatment options is laser therapy, whereby physicians have the option of using ablative lasers (CO2 and Erbium Yttrium Aluminium Garnet) or nonablative fractional laser systems. With ablative laser systems, the superficial layers of the skin are ablated, including epidermal and superficial dermal actinic damage. Re-epithelialization occurs from uninvolved skin and keratinocytes from follicles. When using a CO2 laser, additional cosmetic improvements are a result of removal and tightening of the photodamaged collagen in the superficial dermis...
2015: Current Problems in Dermatology
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