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https://www.readbyqxmd.com/read/28210188/non-contact-photoacoustic-imaging-using-a-commercial-heterodyne-interferometer
#1
Chao Tian, Ting Feng, Cheng Wang, Shengchun Liu, Qian Cheng, David E Oliver, Xueding Wang, Guan Xu
Most current photoacoustic imaging (PAI) systems employ piezoelectric transducers to receive photoacoustic signals, which requires coupling medium to facilitate photoacoustic wave propagation and are not favored in many applications. Here, we report an all-optical non-contact PAI system based on a commercial heterodyne interferometer working at 1550 nm. The interferometer remotely detects ultrasound-induced surface vibration and does not involve any physical contact with the sample. The theoretically predicated and experimentally measured noise equivalent detection limits of the optical sensor are about 4...
December 1, 2016: IEEE Sensors Journal
https://www.readbyqxmd.com/read/28191658/interpatient-mutational-spectrum-of-human-coronavirus-oc43-revealed-by-illumina-sequencing
#2
Geoffrey J Gorse, Gira B Patel, Xiaofeng Fan
Human coronaviruses (HCoV) are RNA viruses that cause respiratory tract infections with viral replication of limited duration. The host and viral population heterogeneity could influence clinical phenotypes. Employing long RT-PCR with Illumina sequencing, we quantified the gene mutation load at 0.5% mutation frequency for the 4,529 bp-domain spanning the Spike gene (4,086 bp) of HCoV-OC43 in four upper respiratory clinical specimens obtained during acute illness. There were a total of 121 mutations for all four HCoV samples with the average number of mutations at 30...
February 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28187492/are-evidence-standards-different-for-genomic-vs-clinical-based-precision-medicine-a-quantitative-analysis-of-individualized-warfarin-therapy
#3
Devender S Dhanda, Gregory F Guzauskas, Josh J Carlson, Anirban Basu, David L Veenstra
Evidence requirements for implementation of precision medicine (PM), whether informed by genomic or clinical data, are not well defined. Evidence requirements are driven by uncertainty and its attendant consequences; these aspects can be quantified by a novel technique in health economics, value of information analysis (VOI). We utilized VOI analysis to compare the evidence levels over time for warfarin dosing based on pharmacogenomic- vs. amiodarone-warfarin drug-drug interaction information. The primary outcome was the expected value of perfect information (EVPI), which is an estimate of the upper limit of the societal value of conducting future research...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28182633/characterizing-the-coding-region-determinant-binding-protein-crd-bp-microphthalmia-associated-transcription-factor-mitf-mrna-interaction
#4
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between CRD-BP and MITF RNA. Using point mutation in the GXXG motif of each KH domains, we showed that all four KH domains of CRD-BP are important for their physical association with MITF RNA. We mapped the CRD-BP-binding site in the 3'-UTR of MITF RNA from nts 1330-1740 and showed that the 49-nt fragment 1621-1669 is the minimal size MITF RNA for binding...
2017: PloS One
https://www.readbyqxmd.com/read/28182411/solvothermal-synthesis-of-cu2sns3-quantum-dots-and-their-application-in-near-infrared-photodetectors
#5
Sandra Dias, Kishan Kumawat, Shinjini Biswas, Salaru Babu Krupanidhi
Cu2SnS3 (CTS) quantum dots were synthesized by solvothermal technique with poly(vinylpyrrolidone) (PVP) as a surfactant. The structural and optical properties were studied using X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, and UV-vis spectroscopy. The electronic band gap was measured using cyclic voltammetry. The infrared photoresponse of the CTS quantum dots-incorporated device was measured under different illumination intensities of the infrared lamp, 1550 and 1064 nm lasers...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28157969/second-order-few-mode-raman-amplifier-for-mode-division-multiplexed-optical-communication-systems
#6
Jiaxiong Li, Jiangbing Du, Lin Ma, Ming-Jun Li, Ke Xu, Zuyuan He
We experimentally demonstrate and investigate, for first time to our best knowledge, a second-order few-mode Raman amplifier for low noise distributed fiber amplification. The 1455 and 1360 nm pumps are both injected into the few-mode fiber (FMF) in the forms of two degenerate LP<sub>11</sub> modes in the backward direction. Within the band from 1542 to 1558 nm, maximum on-off gains of 4 dB are achieved for both LP<sub>01</sub> and LP<sub>11</sub> modes, and the differential modal gain (DMG) is less than 0...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28157957/towards-chip-scale-optical-frequency-synthesis-based-on-optical-heterodyne-phase-locked-loop
#7
Shamsul Arafin, Arda Simsek, Seong-Kyun Kim, Sarvagya Dwivedi, Wei Liang, Danny Eliyahu, Jonathan Klamkin, Andrey Matsko, Leif Johansson, Lute Maleki, Mark Rodwell, Larry Coldren
An integrated heterodyne optical phase-locked loop was designed and demonstrated with an indium phosphide based photonic integrated circuit and commercial off-the-shelf electronic components. As an input reference, a stable microresonator-based optical frequency comb with a 50-dB span of 25 nm (~3 THz) around 1550 nm, having a spacing of ~26 GHz, was used. A widely-tunable on-chip sampled-grating distributed-Bragg-reflector laser is offset locked across multiple comb lines. An arbitrary frequency synthesis between the comb lines is demonstrated by tuning the RF offset source, and better than 100Hz tuning resolution with ± 5 Hz accuracy is obtained...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28155170/treatment-pattern-and-frequency-of-serum-tsh-measurement-in-users-of-different-levothyroxine-formulations-a-population-based-study-during-the-years-2009-2015
#8
Rosarita Ferrara, Valentina Ientile, Vincenzo Arcoraci, Carmen Ferrajolo, Carlo Piccinni, Andrea Fontana, Salvatore Benvenga, Gianluca Trifirò
BACKGROUND: Several conditions can modify the intestinal absorption of levothyroxine tablets, with potential consequences on their therapeutic effect. Pre-dosed ampoules and oral drops have been recently made available to overcome this limitation. AIMS: To describe the pattern of use of different formulations of levothyroxine in a general population of Southern Italy and to perform an exploratory analysis investigating the effect of switching from levothyroxine tablets to oral liquid formulations...
February 2, 2017: Endocrine
https://www.readbyqxmd.com/read/28152736/cancer-depression-and-health-care-coverage-in-the-state-of-nevada-a-retrospective-cross-sectional-study
#9
Manas Agastya, Yaser Dawod, Linha Phan, Mohammad Talha Farooqui, Ji Won Yoo
: 42 Background: The prevalence of depressive disorders in patients with malignancies is estimated at 20-50%, significantly greater than the general population. Existing literature reports a negative impact of depression on both the patient and their families. There is limited information regarding the impact of healthcare coverage on the prevalence of depression in such patients both in the state of Nevada and nationwide. METHODS: A retrospective cross-sectional study was performed using the Behavioral Risk Surveillance System (BRFSS) database from 2010 to 2014...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28146532/upconversion-imaging-using-short-wave-infrared-picosecond-pulses
#10
Morgan Mathez, Peter John Rodrigo, Peter Tidemand-Lichtenberg, Christian Pedersen
To the best of our knowledge, we present the first demonstration of short-wavelength infrared image upconversion that employs intense picosecond signal and pump beams. We use a fiber laser that emits a signal beam at 1877 nm and a pump beam at 1550 nm-both with a pulse width of 1 ps and a pulse repetition rate of 21.7 MHz. Due to synchronization of high peak-power pulses, efficient upconversion is achieved in a single-pass setup that employs a bulk lithium niobate crystal. Optimizing the temporal overlap of the pulses for high upconversion efficiency enables us to exploit a relatively large pump beam diameter to upconvert a wider range of signal spatial frequencies in the crystal...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28114427/burden-of-pneumococcal-disease-in-northern-togo-before-the-introduction-of-pneumococcal-conjugate-vaccine
#11
Jennifer C Moïsi, Makawa-Sy Makawa, Haoua Tall, Kodjo Agbenoko, Berthe-Marie Njanpop-Lafourcade, Stanislas Tamekloe, Moussa Amidou, Judith E Mueller, Bradford D Gessner
BACKGROUND: S. pneumoniae is a leading cause of meningitis morbidity and mortality in the African meningitis belt, but little is known of its contribution to the burden of pneumonia in the region. We aimed to estimate the incidence of pneumococcal disease in children and adults in northern Togo, before the introduction of pneumococcal conjugate vaccine (PCV). METHODS AND FINDINGS: From May 1st 2010 to April 30th 2013, we systematically enrolled all hospitalized patients meeting a case definition of suspected meningitis or clinical pneumonia, residing in Tone or Cinkasse districts, northern Togo and providing informed consent...
2017: PloS One
https://www.readbyqxmd.com/read/28108060/yogurt-consumption-in-infancy-is-inversely-associated-with-atopic-dermatitis-and-food-sensitization-at-5-years-of-age-a-hospital-based-birth-cohort-study
#12
Tetsuo Shoda, Masaki Futamura, Limin Yang, Masami Narita, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: Several studies have suggested that habitual yogurt consumption is associated with favorable outcomes for health issues in children. However, the effects of yogurt consumption on allergic diseases and sensitization in children remain poorly understood. OBJECTIVE: This prospective birth cohort study aimed to investigate for associations between habitual yogurt consumption in infancy and development of allergic diseases/sensitization at 5 years of age...
January 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28095577/optimizing-injections-of-poly-l-lactic-acid-the-6-step-technique
#13
Shino Bay Aguilera, Sean Branch, Luis Soro
The authors present a reproducible and effective technique utilizing poly-L-lactic acid for panfacial revolumization. The variable dilution ratios, reconstitution times, injection techniques and rates of nodule formation with poly-L-lactic acid can be intimidating to even experienced injectors. While there is no single cookie-cutter approach to facial volumization, this 6-step "Precise Sculpt" technique can be used as a template to reliably achieve optimal results while minimizing the risk of adverse events...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28059394/potential-of-a-superconducting-photon-counter-for-heterodyne-detection-at-the-telecommunication-wavelength
#14
M Shcherbatenko, Y Lobanov, A Semenov, V Kovalyuk, A Korneev, R Ozhegov, A Kazakov, B M Voronov, G N Goltsman
Here, we report on the successful operation of a NbN thin film superconducting nanowire single-photon detector (SNSPD) in a coherent mode (as a mixer) at the telecommunication wavelength of 1550 nm. Providing the local oscillator power of the order of a few picowatts, we were practically able to reach the quantum noise limited sensitivity. The intermediate frequency gain bandwidth (also referred to as response or conversion bandwidth) was limited by the spectral band of a single-photon response pulse of the detector, which is proportional to the detector size...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059316/all-optical-tuning-of-eit-like-dielectric-metasurfaces-by-means-of-chalcogenide-phase-change-materials
#15
E Petronijevic, C Sibilia
Electromagnetically induced transparency (EIT) is a pump-induced narrowband transparency window within an absorption line of the probe beam spectrum in an atomic system. In this paper we propose a way to bring together the all-dielectric metamaterials to have EIT-like effects and to optically tune the response by hybridizing them with a layer of a phase change material. We propose a design of the metamaterial based on Si nanoresonators that can support an EIT-like resonant response. On the top of the resonators we consider a thin layer of a chalcogenide phase change material, which we will use to tune the optical response...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059272/graphene-based-side-polished-optical-fiber-amplifier
#16
Mohammad Karimi, Vahid Ahmadi, Masoud Ghezelsefloo
We demonstrate a novel design for optical fiber amplifiers, utilizing side-polished fibers with a single-layer graphene overlay as the active medium and carrier injection in the graphene layer to provide the required inversion. We study the effects of an electrically induced graphene p-i-n heterojunction in the forward bias regime on optical modes of side-polished fibers and show that gain values of 0.51, 1.81, and 1.79 dB/cm for wavelengths 1064, 1330, and 1550 nm can be obtained for single-mode side-polished fibers...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28059250/giant-nonlinear-absorption-and-excited-carrier-dynamics-of-black-phosphorus-few-layer-nanosheets-in-broadband-spectra
#17
Runze Chen, Yuhua Tang, Xin Zheng, Tian Jiang
Layered black phosphorus nanosheets (BPNs) offer potential uses in nanoelectronic and photonics applications. This work demonstrates giant saturable absorption (SA) and two-photon absorption (TPA) of BPNs under femtosecond visible-to-mid-infrared laser-pulse excitation. In addition, the excited carrier dynamics of BPNs were also studied with ultrafast pump-probe technology. Measurements demonstrated that the nonlinear absorption properties of BPNs strongly depend on excitation wavelength and intensity. BPNs moved from SA to TPA under increasing laser intensities at 800, 1160, 1300, and 1550 nm but showed a purely TPA response at 2000 nm, as gauged by measuring BPN nonlinear absorption coefficients...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28059212/large-scale-silicon-nitride-nanophotonic-phased-arrays-at-infrared-and-visible-wavelengths
#18
Christopher V Poulton, Matthew J Byrd, Manan Raval, Zhan Su, Nanxi Li, Erman Timurdogan, Douglas Coolbaugh, Diedrik Vermeulen, Michael R Watts
We demonstrate passive large-scale nanophotonic phased arrays in a CMOS-compatible silicon photonic platform. Silicon nitride waveguides are used to allow for higher input power and lower phase variation compared to a silicon-based distribution network. A phased array at an infrared wavelength of 1550 nm is demonstrated with an ultra-large aperture size of 4  mm×4  mm, achieving a record small and near diffraction-limited spot size of 0.021°×0.021° with a side lobe suppression of 10 dB. A main beam power of 400 mW is observed...
January 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28058285/large-hyperpolarizabilities-at-telecommunication-relevant-wavelengths-in-donor-acceptor-donor-nonlinear-optical-chromophores
#19
Animesh Nayak, Jaehong Park, Kurt De Mey, Xiangqian Hu, Timothy V Duncan, David N Beratan, Koen Clays, Michael J Therien
Octopolar D2-symmetric chromophores, based on the MPZnM supermolecular motif in which (porphinato)zinc(II) (PZn) and ruthenium(II) polypyridyl (M) structural units are connected via ethyne linkages, were synthesized. These structures take advantage of electron-rich meso-arylporphyrin or electron-poor meso-(perfluoroalkyl)porphyrin macrocycles, unsubstituted terpyridyl and 4'-pyrrolidinyl-2,2';6',2″-terpyridyl ligands, and modulation of metal(II) polypyridyl-to-(porphinato)zinc connectivity, to probe how electronic and geometric factors impact the measured hyperpolarizability...
December 28, 2016: ACS Central Science
https://www.readbyqxmd.com/read/28057504/prevalence-of-low-hdl-cholesterol-and-its-associations-among-sri-lankan-patients-with-diabetes-mellitus-on-statin-therapy
#20
Thilak Priyantha Weerarathna, Herath Mudiyanselage Meththananda Herath, Gayani Liyanage
AIMS: We aimed to study the prevalence and associations of suboptimal high density lipoproteins level, a characteristic feature in diabetic dyslipidemia among patients under statin therapy. MATERIALS AND METHODS: From a database of 2416 patients, data on age, gender, duration of diabetes, body mass index (BMI) and waist circumference (WC), low density lipoproteins (LDL), triglyceride, high density lipoproteins (HDL) were obtained. Prevalence of suboptimal HDL (<40mg/dL in males and <50mg/dL in females) and its association with gender, age, duration of diabetes, BMI and WC were studied...
December 26, 2016: Diabetes & Metabolic Syndrome
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