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https://www.readbyqxmd.com/read/28333640/integrated-hifu-drive-system-on-a-chip-for-cmut-based-catheter-ablation-system
#1
Omid Farhanieh, Ali Sahafi, Rupak Bardhan Roy, Arif Sanli Ergun, Ayhan Bozkurt
Conventional High Intensity Focused Ultrasound (HIFU) is a therapeutic modality which is extracorporeally administered. In applications where a relatively small HIFU lesion is required, an intravascular HIFU probe can be deployed to the ablation site. In this paper, we demonstrate the design and implementation a fully integrated HIFU drive system on a chip to be placed on a 6 Fr catheter probe. An 8-element capacitive micromachined ultrasound transducer (CMUT) ring array of 2 mm diameter has been used as the ultrasound source...
March 20, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28331611/long-term-efficacy-of-ultrasound-guided-high-intensity-focused-ultrasound-treatment-of-breast-fibroadenoma
#2
Roussanka Kovatcheva, Katja Zaletel, Jordan Vlahov, Julian Stoinov
BACKGROUND: To assess the long term efficacy and tolerability of one or two ultrasound (US)-guided high-intensity focused ultrasound (HIFU) treatment in patients with breast fibroadenoma (FA). METHODS: Twenty patients with 26 FA were selected for US-guided HIFU. The therapy was performed in one or two sessions. FA volume was assessed before and followed up to 24 months after the last HIFU. After each treatment, adverse events were evaluated. RESULTS: In 19/26 FA (73...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28326895/single-session-high-intensity-focused-ultrasound-treatment-in-large-sized-benign-thyroid-nodules
#3
Brian Hung-Hin Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: High-intensity focused ultrasound (HIFU) is a new promising thermal ablation technique for treating benign thyroid nodules, but its effectiveness in larger-sized nodules has been less well described. The present study aimed to evaluate the treatment efficacy (i.e., extent of shrinkage at six months) of large-sized benign thyroid nodules by ultrasound (USG)-guided HIFU ablation. MATERIALS AND METHODS: After ethics approval, all consecutive patients who underwent HIFU ablation of a symptomatic benign thyroid nodule with six or more months of follow-up were analyzed...
March 22, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28323638/fast-lesion-mapping-during-hifu-treatment-using-harmonic-motion-imaging-guided-focused-ultrasound-hmigfus-in-vitro-and-in-vivo
#4
Yang Han, Shutao Wang, Thomas Payen, Elisa Konofagou
The successful clinical application of high intensity focused ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic motion imaging guided focused ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monitoring, rendering it potentially more sensitive to lesion development. Our group has shown that predicting the lesion location based on the radiation force-excited region is feasible during HMIgFUS...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28301597/boiling-histotripsy-lesion-characterization-on-a-clinical-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-system
#5
Avinash Eranki, Navid Farr, Ari Partanen, Karun V Sharma, Hong Chen, Christopher T Rossi, Satya V V N Kothapalli, Matthew Oetgen, AeRang Kim, Ayele H Negussie, David Woods, Bradford J Wood, Peter C W Kim, Pavel S Yarmolenko
PURPOSE: High intensity focused ultrasound (HIFU) is a non-invasive therapeutic technique that can thermally ablate tumors. Boiling histotripsy (BH) is a HIFU approach that can emulsify tissue in a few milliseconds. Lesion volume and temperature effects for different BH sonication parameters are currently not well characterized. In this work, lesion volume, temperature distribution, and area of lethal thermal dose were characterized for varying BH sonication parameters in tissue-mimicking phantoms (TMP) and demonstrated in ex vivo tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28298940/image-guided-thermal-ablation-of-benign-thyroid-nodules
#6
Anna Pisani Mainini, Cristian Monaco, Lorenzo Carlo Pescatori, Chiara De Angelis, Francesco Sardanelli, Luca Maria Sconfienza, Giovanni Mauri
Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become symptomatic, surgical excision is still considered standard treatment. In the last few years, several experiences in the treatment of benign thyroid nodules through image-guided percutaneous thermal ablation have been reported with encouraging results, so that currently, these treatments are often proposed as first-choice options for patients with symptomatic benign thyroid nodules...
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28297832/-effects-of-high-intensity-focused-ultrasound-on-apoptosis-associated-gene-expression-in-xenografts-with-human-pancreatic-cancer
#7
L L Hong, Z Guo, W G Xing, H P Yu, C F Liu, X L Yang, H L Wang
Objective: To identify the expression of apoptosis-associated genes of high- intensity focused ultrasound(HIFU) in xenograft with human pancreatic cancer. Methods: Mice implated with human pancreatic cancer cells (YY-1) were divided into HIFU group or control group. Tumor cell apoptosis was verified by TUNEL. The expression of the apoptosis-associated genes was analyzed by Agilent Human Gene Expression. Selected genes was validated by quantitative real-time PCR(RT-PCR)and Western blot. Results: The rate of tumor cell apoptosis in HIFU group was higher than that of control group at 7, 14 days after HIFU treatment ((63...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28287747/assessment-of-gold-nano-particle-mediated-enhanced-hyperthermia-using-mr-guided-high-intensity-focused-ultrasound-ablation-procedure
#8
Surendra Balaji Devarakonda, Matthew R Myers, Matthew Lanier, Charles Dumoulin, Rupak Kumar Banerjee
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a non-invasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nano-particles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28280636/the-effect-of-high-intensity-focused-ultrasound-keratoplasty-on-rabbit-anterior-segment
#9
Menglei Wang, Meixuan Li, Pisong Yan, Qiang Luo, Yu Zhang, Zhiyu Du
Purpose. To evaluate the safety of high-intensity focused ultrasound keratoplasty as a treatment for presbyopia by examining its effect on the rabbit anterior segment. Methods. The right corneas of 36 New Zealand rabbits were treated with HIFU keratoplasty. The animals were sacrificed at 1, 7, 15, 30, 60, and 90 days after operation. Collagen type I, MMP-2, and MMP-9 were evaluated using immunohistochemistry. For the detection of apoptosis, the TUNEL method was applied. The SOD and MDA levels were analyzed with assay kits...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28269536/nonlinear-3-d-simulation-of-high-intensity-focused-ultrasound-therapy-in-the-kidney
#10
Visa Suomi, Jiri Jaros, Bradley Treeby, Robin Cleveland
Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268997/photoacoustic-imaging-based-temperature-monitoring-for-high-intensity-focused-ultrasound-therapy
#11
Xun Wu, Jean Lunsford Sanders, Douglas N Stephens, Omer Oralkan
Temperature monitoring during high-intensity focused ultrasound (HIFU) application is necessary to ensure effective therapy while minimizing thermal damage to adjacent tissue. In this study, we demonstrate a noninvasive approach for temperature measurement during HIFU therapy based on photoacoustic imaging (PAI). Because of the dependence of photoacoustic (PA) signal amplitude on temperature of the source tissue and the linearity of the PAI system, changes in temperature will cause changes in PA image intensity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267526/high-intensity-focused-ultrasound-treatment-of-adenomyosis-the-relationship-between-the-features-of-magnetic-resonance-imaging-on-t2-weighted-images-and-the-therapeutic-efficacy
#12
Chunmei Gong, Raymond Setzen, Zhongqiong Liu, Yunchang Liu, Bin Xie, Aixingzi Aili, Lian Zhang
OBJECTIVES: To investigate the relationship between the features of magnetic resonance imaging (MRI) on T2 weighted images (T2WI) and the therapeutic efficacy of high intensity focused ultrasound (HIFU) on adenomyosis. MATERIALS AND METHODS: From January 2011 to November 2015, four hundred and twenty-eight patients with symptomatic adenomyosis were treated with HIFU. Based on the signal intensity and the number of hyperintense foci in the adenomyotic lesions on T2WI, the patients were classified into groups...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28267055/overactive-bladder-syndrome-and-lower-urinary-tract-symptoms-after-prostate-cancer-treatment
#13
Suzanne Biers, Karl-Dietrich Sievert, Nikesh Thiruchelvam
PURPOSE OF REVIEW: To assess the contemporary literature on the prevalence, cause and management of lower urinary tract symptoms (LUTS) and bladder overactivity following treatment of prostate cancer with radical surgery, radiotherapy and minimally invasive therapies for localized prostate cancer, including cryotherapy and high-intensity focused ultrasound (HIFU). RECENT FINDINGS: Generally, the highest risk of urinary incontinence is after open radical prostatectomy (7-40%), although not all contemporary studies demonstrate a difference between open and laparoscopic techniques...
March 4, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28258616/focal-salvage-hifu-in-radiorecurrent-prostate-cancer
#14
A Kanthabalan, M Peters, M Van Vulpen, N McCartan, R G Hindley, A Emara, M C Moore, M Arya, M Emberton, H U Ahmed
OBJECTIVE: To assess short to medium term cancer control rates and side effects of focal salvage High Intensity Focused Ultrasound (HIFU). MATERIALS AND METHODS: A retrospective registry analysis identified 150 men who underwent focal salvage HIFU (Sonablate 500) (November 2006-August 2015). Metastatic disease was excluded using the nodal assessment on the pelvic MRI, a radioisotope bone scan and PET imaging (choline-FDG-PET or Choline PET-CT). In our current clinical practice, metastatic disease must be ruled out by both Choline PET and bone scan...
March 4, 2017: BJU International
https://www.readbyqxmd.com/read/28257990/extracellular-matrix-remodeling-in-vivo-for-enhancing-tumor-targeting-efficiency-of-nanoparticle-drug-carriers-using-the-pulsed-high-intensity-focused-ultrasound
#15
Sangmin Lee, Hyounkoo Han, Heebeom Koo, Jin Hee Na, Hong Yeol Yoon, Kyung Eun Lee, Hyukjin Lee, Hyuncheol Kim, Ick Chan Kwon, Kwangmeyung Kim
Dense and stiff extracellular matrix (ECM) in heterogeneous tumor tissues can inhibit deep penetration of nanoparticle drug carriers and decreases their therapeutic efficacy. Herein, we suggest the ECM remodeling strategy by the pulsed high intensity focused ultrasound (Pulsed-HIFU) technology for enhanced tumor-targeting of nanoparticles. First, we clearly observed that the tumor-targeting efficacy and tissue penetration of intravenously injected Cy5.5-labled glycol chitosan nanoparticles (Cy5.5-CNPs) were greatly inhibited in tumor tissue containing high collagen and hyaluronan contents in ECM-rich A549 tumor-bearing mice, compared to in ECM-less SCC7...
February 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28256923/ultrasound-guided-high-intensity-focused-ultrasound-combined-with-gonadotropin-releasing-hormone-analogue-gnrha-ablating-uterine-leiomyoma-with-homogeneous-hyperintensity-on-t2-weighted-mr-imaging
#16
Shenghua Yang, Fanjing Kong, Ruijie Hou, Fengmin Rong, Nana Ma, Shaoping Li, Jun Yang
OBJECTIVES: The study aimed to evaluate the safety and efficiency of Ultrasound guided high-intensity focused ultrasound (USgHIFU) combined with gonadotropin releasing hormone analogue (GnRHa) ablating symptomatic uterine leiomyoma with homogeneous hyperintensity on T2-weighted MR imaging prospectively. METHODS: A total of 34 patients with 42 symptomatic uterine leiomyomas with homogeneous hyperintensity on T2-weighted MR imaging were enrolled in our study. The patient who had multiple uterine leiomyomas, only one dominant leiomyoma was treated...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28255360/nanoparticles-formed-by-acoustic-destruction-of-microbubbles-and-their-utilization-for-imaging-and-effects-on-therapy-by-high-intensity-focused-ultrasound
#17
Nicholas T Blum, Adem Yildirim, Rajarshi Chattaraj, Andrew P Goodwin
This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs) are of 150 nm average diameter and can be re-imaged for up to an hour after creation for C 4F10, and for at least one day for C5F12. The active species were found to be fluid (gas or liquid) filled nanoparticles rather than lipid debris...
2017: Theranostics
https://www.readbyqxmd.com/read/28255351/tracking-perfluorocarbon-nanoemulsion-delivery-by-19-f-mri-for-precise-high-intensity-focused-ultrasound-tumor-ablation
#18
Soo Hyun Shin, Eun-Joo Park, Changki Min, Sun Il Choi, Soyeon Jeon, Yun-Hee Kim, Daehong Kim
Perfluorocarbon nanoemulsions (PFCNEs) have recently been undergoing rigorous study to investigate their ability to improve the therapeutic efficacy of tumor ablation by high intensity focused ultrasound (HIFU). For precise control of PFCNE delivery and thermal ablation, their accumulation and distribution in a tumor should be quantitatively analyzed. Here, we used fluorine-19 ((19)F) magnetic resonance imaging (MRI) to quantitatively track PFCNE accumulation in a tumor, and analyzed how intra-tumoral PFCNE quantities affect the therapeutic efficacy of HIFU treatment...
2017: Theranostics
https://www.readbyqxmd.com/read/28247630/-salvage-external-beam-radiation-therapy-for-prostate-cancer-recurrence-after-high-intensity-focused-ultrasound-ablation
#19
R N Fomkin, V M Popkov, T V Shatylko
The article outlines oncological and functional outcomes of salvage external beam radiation therapy after HIFU-ablation in 49 patients. The study determined overall and relapse-free survival, compared the rates of adverse events stratified by CTCAE, erectile function and continence scores assessed by questionnaire survey. Univariate and multivariate analysis of risk factors for failure of salvage radiation therapy after prostate HIFU-ablation were conducted. In univariate analysis the level of prostate-specific antigen (PSA) prior to radiotherapy, the risk group, PSA nadir after radiotherapy, PSA nadir greater than 0...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243479/robotic-assisted-laparoscopic-prostatectomy-after-high-intensity-focused-ultrasound-failure
#20
Leon Telis, Seyed Behzad Jazayeri, David B Samadi
Background. Prostate cancer is the most common cancer diagnosed in men. As new focal therapies become more popular in treatment of prostate cancer, failure cases requiring salvage therapy with either surgical or other techniques are being reported. Objective. To report the options in treatment of prostate cancer after recurrence or failure of the primary treatment modality. Methods. We report a salvage robotic assisted laparoscopic radical prostatectomy (RALP) for prostate cancer recurrence following high intensity focused ultrasound treatment (HIFU) in the United States...
2017: Case Reports in Urology
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