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https://www.readbyqxmd.com/read/28210800/preservation-of-the-endometrial-enhancement-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation-of-submucosal-uterine-fibroids
#1
Young-Sun Kim, Tae-Joong Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Joong Hyun Ahn, Jeong-Won Lee, Byoung-Gie Kim
OBJECTIVE: To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS: In total, 117 submucosal fibroids (diameter: 5.9 ± 3.0 cm) in 101 women (age: 43.6 ± 4.4 years) treated with MR-HIFU ablation were retrospectively analysed...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28194274/moderate-to-deep-sedation-technique-using-propofol-and-ketamine-allowing-synchronised-breathing-for-magnetic-resonance-high-intensity-focused-ultrasound-mr-hifu-treatment-for-uterine-fibroids-a-pilot-study
#2
Hermanus H B Vaessen, F M Knuttel, J M M van Breugel, M E Ikink, J M Dieleman, M A A J van den Bosch, J T A Knape
BACKGROUND: Magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids is rapidly gaining popularity as a treatment modality. This procedure is generally uncomfortable, painful, and requires minimal or absence of movement and an MR-HIFU synchronised breathing pattern of the patient. Procedural sedation and analgesia protocols have become the standard practice in interventional radiology departments worldwide. The aim of this study was to explore if a sedation regimen with low-dose propofol and ketamine performed by trained non-medical sedation practitioners could result in relief of discomfort for the patient and in adequate working conditions for MR-HIFU treatment for uterine fibroids...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28167319/uniform-tissue-lesion-formation-induced-by-high-intensity-focused-ultrasound-along-a-spiral-pathway
#3
Kui Qian, Chenghai Li, Zhengyang Ni, Juan Tu, Xiasheng Guo, Dong Zhang
Both theoretical and experimental studies were performed here to investigate the lesion formation induced by high-intensity focused ultrasound (HIFU) operating in continuous scanning mode along a spiral pathway. The Khokhlov-Zabolotskaya-Kuznetsov equation and bio-heat equation were combined in the current model to predict HIFU-induced temperature distribution and lesion formation. The shape of lesion and treatment efficiency were assessed for a given scanning speed at two different grid spacing (3mm and 4mm) in the gel phantom studies and further researched in ex vivo studies...
January 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28166812/efficacy-of-high-intensity-focused-ultrasound-assisted-hepatic-resection-hifu-ar-on-blood-loss-reduction-in-patients-with-liver-metastases-requiring-hepatectomy-study-protocol-for-a-randomized-controlled-trial
#4
Aurélien Dupré, David Pérol, Ellen Blanc, Patrice Peyrat, Valéria Basso, Yao Chen, Jérémy Vincenot, Anthony Kocot, David Melodelima, Michel Rivoire
BACKGROUND: Liver resection is the only potentially curative treatment for colorectal liver metastases (LM). It is considered a safe procedure, but is often associated with blood loss during liver transection. Blood transfusions are frequently needed, but they are associated with increased morbidity and risk of recurrence. Many surgical devices have been developed to decrease blood loss. However, none of them has proven superior to the standard crushing technique. We developed a new, powerful intra-operative high-intensity focused ultrasound (HIFU) transducer which destroys tissue by coagulative necrosis...
February 6, 2017: Trials
https://www.readbyqxmd.com/read/28150435/study-of-efficacy-of-esthetic-high-intensity-focused-ultrasound-system-on-iranian-skin-for-reducing-the-laxity-and-wrinkles-of-aging
#5
Parvaneh Saket, Shobeir Shobeihi, Soroush Mehrdadi
BACKGROUND: Ultrasound is a mechanical wave that transmitted in a straight line and it can be focused at frequencies of 1-7 MHz with a high degree of precision. An important aspect of HIFU is that damaging focal point is located several millimeters below the surface of the skin and tissue above and below the focal point remains unaffected. Due to absorption of this energy, temperature of tissue rises to more than 60°C and this stimulates the cells for collagen production and tissue rejuvenation...
February 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28135577/piv-for-the-characterization-of-focused-field-induced-acoustic-streaming-seeding-particle-choice-evaluation
#6
Rafika Ben Haj Slama, Bruno Gilles, Maher Ben Chiekh, Jean-Christophe Béra
This research evaluates the use of Particle Image Velocimetry (PIV) technique for characterizing acoustic streaming flow generated by High Intensity Focused Ultrasound (HIFU). PIV qualification tests, focusing on the seeding particle size (diameter of 5, 20 and 50μm) were carried out in degassed water subjected to a focused field of 550kHz-frequency with an acoustic pressure amplitude of 5.2, 10.5 and 15.7bar at the focus. This study shows that the ultrasonic field, especially the radiation force, can strongly affect seeding particle behavior...
January 14, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28123436/review-of-the-mechanisms-and-effects-of-noninvasive-body-contouring-devices-on-cellulite-and-subcutaneous-fat
#7
REVIEW
Zahra Alizadeh, Farzin Halabchi, Reza Mazaheri, Maryam Abolhasani, Mastaneh Tabesh
CONTEXT: Today, different kinds of non-invasive body contouring modalities, including cryolipolysis, radiofrequency (RF), low-level laser therapy (LLLT), and high-intensity focused ultrasound (HIFU) are available for reducing the volume of subcutaneous adipose tissue or cellulite. Each procedure has distinct mechanisms for stimulating apoptosis or necrosis adipose tissue. In addition to the mentioned techniques, some investigations are underway for analyzing the efficacy of other techniques such as whole body vibration (WBV) and extracorporeal shockwave therapy (ESWT)...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28121624/destructive-effect-of-hifu-on-rabbit-embedded-endometrial-carcinoma-tissues-and-their-vascularities
#8
Liming Guan, Gang Xu
OBJECTIVES: To evaluate damage effect of High-intensity focused ultrasound on early stage endometrial cancer tissues and their vascularities. MATERIALS AND METHODS: Rabbit endometrial cancer models were established via tumor blocks implantation for a prospective control study. Ultrasonic ablation efficacy was evaluated by pathologic and imaging changes. The target lesions of experimental rabbits before and after ultrasonic ablation were observed after autopsy. The slides were used for hematoxylin-eosin staining, elastic fiber staining and endothelial cell staining; the slides were observed by optical microscopy...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28119901/erratum-to-hifu-effects-and-clinical-effectiveness-of-non-surgical-therapy-for-uterine-fibroids
#9
Ikjin Chang, Kyung Jin Hwang, Ho Jin Choi, Ho Sun Chang, Hyo Jin Yoon, Eung Seok Lee, Sun Young Choi
[This corrects the article on p. 59 in vol. 22, PMID: 27617237.].
December 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28119893/expulsion-of-fibroids-to-the-endometrial-cavity-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-surgery-mrgfus-treatment-of-intramural-uterine-fibroids
#10
Jae-Hyeok Jeong, Gil Pyo Hong, Yu-Ri Kim, Da Gyo Hong, Jae-Eun Ha, Jung In Yeom, Eun-Jeong Kim, Hyung-Il Kim, Kyu-Sup Lee
OBJECTIVES: This report seeks to introduce some cases of the patients who received magnetic resonance imaging (MRI)-guided high intensity focused ultrasound (HIFU) surgery (MRgFUS)-based intramural uterine fibroids treatment where the post-MRgFUS intramural uterine fibroids decreased in its volume and protruded towards the endometrial cavity to be expelled by hysteroscopy. METHODS: Of the 157 patients who had received MRgFUS treatment in the Obstetrics and Gynecology of the Hospital from March, 2015 to February, 2016; this study examined 6 of the cases where, after high intensity focused ultrasound treatment, intramural uterine fibroids protruded towards the endometrial cavity to be removed by hysteroscopic myomectomy...
December 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28113706/effects-of-temperature-on-the-histotripsy-intrinsic-threshold-for-cavitation
#11
Eli Vlaisavljevich, Zhen Xu, Adam Maxwell, Lauren Mancia, Xi Zhang, Kuang-Wei Lin, Alexander Duryea, Jonathan Sukovich, Tim Hall, Eric Johnsen, Charles Cain
Histotripsy is an ultrasound ablation method that depends on the initiation of a dense cavitation bubble cloud to fractionate soft tissue. Previous work has demonstrated that a cavitation cloud can be formed by a single acoustic pulse with one high amplitude negative cycle, when the negative pressure amplitude exceeds a threshold intrinsic to the medium. The intrinsic thresholds in soft tissues and tissue phantoms that are water-based are similar to the intrinsic threshold of water over an experimentally verified frequency range of 0...
May 10, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28113364/-i-ex-vivo-i-hifu-experiments-using-a-32%C3%A3-32-element-cmut-array
#12
Hyo-Seon Yoon, Chienliu Chang, Ji Hoon Jang, Anshuman Bhuyan, Jung Woo Choe, Amin Nikoozadeh, Ronald Watkins, Doug Stephens, Kim Butts Pauly, Butrus Khuri-Yakub
High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8×8-mm2, 32×32-element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point...
September 5, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28109895/pilot-study-of-the-mirabilis-system-prototype-for-rapid-noninvasive-uterine-fibroid-treatment-using-an-ultrasound-guided-volumetric-shell-ablation-technique
#13
Jessica E Parsons, Michael P H Lau, Patrick J Martin, Joel J Islas Lagos, Juan M Aguilar Aguirre, José G Garza Leal
STUDY OBJECTIVE: The primary objective of this pilot study was to evaluate the safety and acute tissue ablation efficacy of a transabdominal high-intensity focused ultrasound (HIFU) prototype device that uses ultrasound imaging guidance for rapid noninvasive ablation of uterine fibroids. The secondary objective was to assess preliminary fibroid-related symptom improvement and fibroid volume reduction at 3 - 6 months post-treatment in subsets of patients. DESIGN: Multi-center prospective single-arm pilot study (Canadian Task Force Classification II-2) SETTING: University-affiliated teaching hospital and private community hospital PATIENTS: Women with a diagnosis of symptomatic uterine fibroids planning to undergo hysterectomy INTERVENTIONS: Seventy-three (73) women underwent transabdominal ultrasound-guided HIFU treatment using a volumetric ablation technique referred to as 'shell ablation,' in which the HIFU energy is deposited in patterns that partially encapsulate the peripheral region of the targeted fibroid(s)...
January 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28107023/doxorubicin-delivery-into-tumor-cells-by-stable-cavitation-without-contrast-agents
#14
Kamel Chettab, Jean-Louis Mestas, Maxime Lafond, Djamel Eddine Saadna, Cyril Lafon, Charles Dumontet
Doxorubicin, alone or in combination with other anticancer agents, is one of the most widely used chemotherapeutic agents and is administered in a wide range of cancers. However, the use of doxorubicin is limited due to its potential serious adverse reactions. Previous studies have established the ability of high intensity focused ultrasound (HIFU) in combination with various contrast agents to increase intracellular doxorubicin delivery in a targeted and noninvasive manner. In this study, we developed a new sonoporation device generating and monitoring acoustic cavitation bubbles without any addition of contrast agents...
January 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28096917/assessment-of-histopathological-features-of-needle-biopsy-in-recurrent-prostate-cancer-following-salvage-high-intensity-focused-ultrasound
#15
Michele Billia, Khurram M Siddiqui, Susanne Chan, Fan Li, Ali Al-Zahrani, Jose A Gomez, Joseph L Chin
INTRODUCTION: Local recurrence of prostate cancer (PCa) following radiotherapy may be treated with curative intent using salvage high-intensity focused ultrasound (s-HIFU). The interpretation of needle core biopsy specimens following s-HIFU is a daunting task, even for experienced pathologists. We describe various histopathological features encountered in biopsy specimens following whole-gland s-HIFU in one of the largest descriptive studies to date. METHODS: Fifty-five patients with biopsy-proven localized radio-recurrent PCa underwent s-HIFU and transrectal ultrasound (TRUS)-guided prostatic needle biopsies at 180 days post-treatment...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28090656/real-time-monitoring-of-tissue-displacement-and-temperature-changes-during-mr-guided-high-intensity-focused-ultrasound
#16
Pierre Bour, Fabrice Marquet, Valéry Ozenne, Solenn Toupin, Erik Dumont, Jean-François Aubry, Matthieu Lepetit-Coiffe, Bruno Quesson
PURPOSE: The therapy endpoint most commonly used in MR-guided high intensity focused ultrasound is the thermal dose. Although namely correlated with nonviable tissue, it does not account for changes in mechanical properties of tissue during ablation. This study presents a new acquisition sequence for multislice, subsecond and simultaneous imaging of tissue temperature and displacement during ablation. METHODS: A single-shot echo planar imaging sequence was implemented using a pair of motion-encoding gradients, with alternated polarities...
January 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28077116/quality-of-life-and-functional-outcome-after-infravesical-desobstruction-and-hifu-treatment-for-localized-prostate-cancer
#17
G Hatiboglu, I V Popeneciu, M Deppert, J Nyarangi-Dix, B Hadaschik, M Hohenfellner, D Teber, S Pahernik
BACKGROUND: To evaluate quality of life, functional and oncological outcome after infravesical desobstruction and HIFU treatment for localized prostate cancer. METHODS: One hundred thirty-one patients, treated with TURP and HIFU in a single institution were followed up for oncological and functional outcome. Oncological outcome was quantified by biochemical recurrence free survival using the Stuttgart and Phoenix criteria. Quality of life was assessed by usage of standardized QLQ-C30 and QLQ-PR25 questionnaires...
January 11, 2017: BMC Urology
https://www.readbyqxmd.com/read/28069221/effects-of-different-hydrostatic-pressure-on-lesions-in-ex-vivo-bovine-livers-induced-by-high-intensity-focused-ultrasound
#18
Min He, Zhiqiang Zhong, Xing Li, Xiaobo Gong, Zhibiao Wang, Faqi Li
It is well-known that acoustic cavitation associated with the high intensity focused ultrasound (HIFU) treatment often would change the morphology and size of lesions in its treatment. In most studies reported in literature, high ambient hydrostatic pressure was used to suppress the cavitation completely. Investigation of the effects by varying the ambient hydrostatic pressure (Pstat) is still lacking. In this paper, the effects of HIFU on lesions in ex vivo bovine liver specimens under various Pstat are systematically investigated...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28069193/safety-of-ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-diffuse-adenomyosis-a-retrospective-cohort-study
#19
Yujie Feng, Liang Hu, Wenzhi Chen, Rong Zhang, Xi Wang, Jinyun Chen
OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F)...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067975/assessment-of-acute-thermal-damage-volumes-in-muscle-using-magnetization-prepared-3d-t2-weighted-imaging-following-mri-guided-high-intensity-focused-ultrasound-therapy
#20
Robert M Staruch, Joris Nofiele, Jamie Walker, Chenchen Bing, Ananth J Madhuranthakam, April Bailey, Young-Sun Kim, Avneesh Chhabra, Dennis Burns, Rajiv Chopra
PURPOSE: To evaluate magnetization-prepared 3D T2 -weighted magnetic resonance imaging (MRI) measurements of acute tissue changes produced during ablative MR high-intensity focused ultrasound (MR-HIFU) exposures. MATERIALS AND METHODS: A clinical MR-HIFU system (3T) was used to generate thermal lesions (n = 24) in the skeletal muscles of three pigs. T1 -weighted, 2D T2 -weighted, and magnetization-prepared 3D T2 -weighted sequences were acquired before and after therapy to evaluate tissue changes following ablation...
January 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
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