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https://www.readbyqxmd.com/read/27913330/ex-vivo-hifu-experiments-using-a-32-times-32-element-cmut-array
#1
Hyo-Seon Yoon, Chienliu Chang, Ji Hoon Jang, Anshuman Bhuyan, Jung Woo Choe, Amin Nikoozadeh, Ronald D Watkins, Douglas N Stephens, Kim Butts Pauly, Butrus T Khuri-Yakub
High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8 ×8 -mm (2) 32 ×32 -element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27913213/enhanced-efficacy-of-combination-heat-shock-targeted-polymer-therapeutics-with-high-intensity-focused-ultrasound
#2
Nick Frazier, Allison Payne, Christopher Dillon, Nithya Subrahmanyam, Hamidreza Ghandehari
Combination of polymer therapeutics and hyperthermia has been shown to enhance accumulation in selectively heated tumor tissue. The additional use of heat shock (HS)-targeting towards tumor tissues can further enhance accumulation and retention, and improve therapeutic outcomes. In this work, high intensity focused ultrasound (HIFU) was used to generate hyperthermia in prostate tumor tissue. Upregulation of the cell surface HS receptor glucose regulated protein 78kDa (GRP78) was observed after treatment with HIFU hyperthermia which was then targeted by specific HS-targeting peptides...
November 29, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27881031/cavitation-enhances-coagulated-size-during-pulsed-high-intensity-focussed-ultrasound-ablation-in-an-isolated-liver-perfusion-system
#3
Lu-Yan Zhao, Shan Liu, Zong-Gui Chen, Jian-Zhong Zou, Feng Wu
PURPOSE: To investigate whether cavitation enhances the degree of coagulation during pulsed high-intensity focussed ultrasound (HIFU) in an isolated liver perfusion system. METHODS: Isolated liver was treated by pulsed HIFU or continuous-wave HIFU with different portal vein flow rates. The cavitation emission during exposure was recorded, and real-time ultrasound images were used to observe changes in the grey scale. The coagulation size was measured and calculated...
November 24, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27868241/high-intensity-focused-ultrasound-treatment-for-skin-ex-vivo-evaluation
#4
J-H Park, S-D Lim, S H Oh, J H Lee, U C Yeo
BACKGROUND/PURPOSE: High-intensity focused ultrasound (HIFU) has been used for skin tightening. However, there is a rising concern of irreversible adverse effects. Our aim was to evaluate the depth of thermal injury zone after HIFU energy passes through different condition. MATERIALS AND METHODS: To analyze the consistency of the HIFU device, phantom tests were performed. Simulations were performed on ex vivo porcine tissues to estimate the area of the thermal coagulation point (TCP) according to the applied energy and skin condition...
November 20, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27867812/comparisons-of-oncological-and-functional-outcomes-among-radical-retropubic-prostatectomy-high-dose-rate-brachytherapy-cryoablation-and-high-intensity-focused-ultrasound-for-localized-prostate-cancer
#5
Po Hui Chiang, Yi Yang Liu
PURPOSE: To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. METHODS: We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and HIFU respectively for localized prostate cancer from May 2008 to December 2013. PSA biochemical recurrence, salvage treatment-free rate, metastasis-free rate, and biochemical recurrence-free survival were analyzed for oncological outcomes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27835871/comparing-the-long-term-efficacy-of-standard-and-combined-minimally-invasive-procedures-for-unresectable-hcc-a-mixed-treatment-comparison
#6
Jianghai Zhao, Hui Zhang, Lunshou Wei, Shuping Xie, Zhimin Suo
A small proportion of hepatocellular carcinoma (HCC) patients are suitable for surgical resections and various minimally invasive procedures have been introduced as alternatives to surgical resections. However, the relative efficacy of minimally invasive procedures remains to be studied in the current literature. Several popular minimally invasive procedures (monotherapy or combined therapies) were selected for comparison and their relative long-term efficacy were determined by using the statistics of hazard ratio (HR) which evaluates the survival status of HCC patients in one, two, three and four years, respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827415/non-invasive-cardiac-pacing-with-image-guided-focused-ultrasound
#7
Fabrice Marquet, Pierre Bour, Fanny Vaillant, Sana Amraoui, Rémi Dubois, Philippe Ritter, Michel Haïssaguerre, Mélèze Hocini, Olivier Bernus, Bruno Quesson
Currently, no non-invasive cardiac pacing device acceptable for prolonged use in conscious patients exists. High Intensity Focused Ultrasound (HIFU) can be used to perform remote pacing using reversibility of electromechanical coupling of cardiomyocytes. Here we described an extracorporeal cardiac stimulation device and study its efficacy and safety. We conducted experiments ex vivo and in vivo in a large animal model (pig) to evaluate clinical potential of such a technique. The stimulation threshold was determined in 10 different ex vivo hearts and different clinically relevant electrical effects such as consecutive stimulations of different heart chambers with a single ultrasonic probe, continuous pacing or the inducibility of ventricular tachycardia were shown...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822376/the-safety-and-effectiveness-of-volumetric-magnetic-resonance-guided-high-intensity-focused-ultrasound-treatment-of-symptomatic-uterine-fibroids-early-clinical-experience-in-china
#8
Rui Chen, Bilgin Keserci, Hui Bi, Xiaobing Han, Xiaoying Wang, Wenpei Bai, Yueling Wang, Xuedong Yang, Jian Yang, Juan Wei, Minna Seppälä, Antti Viitala, Qinping Liao
BACKGROUND: Uterine fibroids are the most common benign tumor in women, and surgical intervention is still the main fibroid treatment. Patient demands have encouraged development of less-invasive methods such as high-intensity focused ultrasound (HIFU). This study aimed to evaluate the safety and effectiveness of magnetic resonance-guided high-intensity focused ultrasound therapy using a volumetric ablation technique in the treatment of symptomatic uterine fibroids in China. METHODS: One hundred and seven patients were enrolled and treated with magnetic resonance-guided high-intensity focused ultrasound in this study...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27804180/non-invasive-high-intensity-focused-ultrasound-treatment-of-the-placental-unit-preliminary-in-vivo-study-using-a-monkey-model-of-pregnancy
#9
J Caloone, C Huissoud, A Kocot, J Vincenot, C Dehay, P Giroud, P Misery, F Allias, R C Rudigoz, D Melodelima
OBJECTIVE: To demonstrate the feasibility and efficacy of high-intensity focused ultrasound (HIFU) to non-invasively treat placental tissues in a monkey model of pregnancy. MATERIALS AND METHODS: A toroidal HIFU transducer working at 2.5 MHz with an integrated ultrasound-imaging probe was used. Eight pregnant monkeys were exposed to HIFU treatment after anesthesia. Lesions on placental tissues were performed non-invasively by placing the HIFU probe on the skin. Fetal and maternal parameters, such as maternal heart rate, fetal heart rate, and subcutaneous and intra-amniotic fluid temperature, were recorded during HIFU exposure...
November 2, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27799004/comparing-high-intensity-focal-ultrasound-hemiablation-to-robotic-radical-prostatectomy-in-the-management-of-unilateral-prostate-cancer-a-matched-pair-analysis
#10
Simone Albisinni, Fouad Aoun, Simon Bellucci, Ibrahim Biaou, Ksenija Limani, Eric Hawaux, Alexandre Peltier, Roland van Velthoven
INTRODUCTION: Although still experimental, focal treatment is being increasingly implemented in the management of prostate cancer (PCa). Aim of the current study was to compare functional and oncologic outcomes of high-intensity focal ultrasound (HIFU) hemiablation of the prostate to robot-assisted laparoscopic prostatectomy (RALP) in the management of unilateral PCa. MATERIALS: Fifty-five men with unilateral, clinically localized PCa underwent HIFU hemiablation of the affected prostatic lobe between 2007 and 2015...
November 30, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27783026/combined-stent-insertion-and-high-intensity-focused-ultrasound-ablation-for-patients-with-malignant-obstructive-jaundice
#11
Su Niu, Long Cheng, Yan Qiao, Yu-Fei Fu, Chi Cao
PURPOSE: We aimed to determine the clinical effectiveness of combined stent insertion and high-intensity focused ultrasound (HIFU) ablation for patients with malignant obstructive jaundice (MOJ). MATERIALS AND METHODS: From June 2013 to May 2015, consecutive patients with inoperable MOJ underwent biliary stent with or without HIFU ablation in our center. Treatment-related complications, stent patency time, and survival time were compared between 2 groups. RESULTS: During the enrolled time, a total of 51 patients with MOJ underwent biliary stent with HIFU ablation (n=24) or biliary stent only (n=27) in our center...
October 25, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27780661/high-intensity-focused-ultrasound-and-radiation-therapy-induced-immuno-modulation-comparison-and-potential-opportunities
#12
REVIEW
Roberta Cirincione, Federica Maria Di Maggio, Giusi Irma Forte, Luigi Minafra, Valentina Bravatà, Laura Castiglia, Vincenzo Cavalieri, Giovanni Borasi, Giorgio Russo, Domenico Lio, Cristina Messa, Maria Carla Gilardi, Francesco Paolo Cammarata
In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity...
October 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27777197/-effect-of-low-dose-focused-ultrasound-pre-irradiation-versus-microbubbles-for-enhancing-high-intensity-focused-ultrasound-ablation-of-vx2-hepatic-tumor-in-rabbits
#13
Yi Zhang, Chao Yang, Jian-Zhong Zou, Fei Chen, Xia Ou, Hai-Rong Zou, Yan Wang
OBJECTIVE: To compare the effect of low-dose focused ultrasound pre-irradiation and microbubbles for enhancing the ablation effect of high intensity focused ultrasound (HIFU) on VX2 hepatic tumor in rabbits. METHODS: Fifty-five rabbits bearing VX2 hepatic tumor were randomly divided into low-dose pre-irradiation + HIFU ablation group, microbubbles+HIFU ablation group, and HIFU ablation group for corresponding treatments. The pathological changes in the tumors after low-dose irradiation, time for HIFU ablation, tumor volume with coagulative necrosis, energy efficiency factor (EEF), pathological changes in the ablated tumor, and sound channel of HIFU ablation were observed...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27775904/design-of-hifu-transducers-for-generating-specified-nonlinear-ultrasound-fields
#14
Pavel B Rosnitskiy, P V Yuldashev, Oleg A Sapozhnikov, Adam Maxwell, Wayne Kreider, Michael R Bailey, Vera A Khokhlova
Various clinical applications of high intensity focused ultrasound (HIFU) have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this work was to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasilinear conditions at the focus. Multiparametric nonlinear modeling based on the KZK equation with an equivalent source boundary condition was employed...
October 20, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27774787/template-free-synthesis-of-hollow-porous-organosilica-fe3o4-hybrid-nanocapsules-towards-mri-guided-high-intensity-focused-ultrasound-therapy
#15
Ming Ma, Fei Yan, Minghua Yao, Zijun Wei, Dongliang Zhou, Heliang Yao, Hairong Zheng, Hangrong Chen, Jianlin Shi
Entirely differing from the common templating-based multistep strategy in fabricating multifunctional hollow mesoporous silica nanoparticles (HMSNs), a facile and template-free synthetic strategy has been established in constructing a unique hollow/mesoporous organosilica nanocapsule concurrently encapsulating both isopentyl acetate (PEA) liquid and superparamagnetic iron oxides inside (denoted as PEA@OSNCs). This novel material exhibits ultrasmall and uniform particle size (~82 nm), high surface area (~534 m2 g-1) and excellent colloidal stability in aqueous solution...
October 24, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27766442/synergistic-effect-of-high-intensity-focused-ultrasound-and-low-fluence-q-switched-nd-yag-laser-in-the-treatment-of-the-aging-neck-and-d%C3%A3-colletage
#16
Jae-Hui Nam, Young-Jun Choi, Jae Yun Lim, Joon Hong Min, Won-Serk Kim
High-intensity focused ultrasound (HIFU) is regarded as an effective skin-lifting device; however, literature regarding treatment of the aging neck and décolletage with HIFU is scarce. Our study aimed to evaluate the efficacy of combination with HIFU and low-fluence Q-switched Nd:YAG (LQSNY) laser on the aging neck and décolletage. Nineteen women were assessed. HIFU at two visits and LQSNY laser at six visits were used to irradiate the neck and chest. At week 16, improvements were rated using the Dedo classification, Fabi/Bolton Chest Wrinkle Scale (FBCWS), and Global Aesthetic Improvement Scales (GAIS)...
October 20, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27766022/flooded-lung-generates-a-suitable-acoustic-pathway-for-transthoracic-application-of-high-intensity-focused-ultrasound-in-liver
#17
Thomas Günther Lesser, Carsten Boltze, Harald Schubert, Frank Wolfram
Background: In recent years, high intensity focused ultrasound (HIFU) has gained increasing clinical interest as a non-invasive method for local therapy of liver malignancies. HIFU treatment of tumours and metastases in the liver dome is limited due to the adjacent ultrasound blocking lung. One-lung flooding (OLF) enables complete sonography of lung and adjoining organs including liver. HIFU liver ablation passing through the flooded lung could enable a direct intercostal beam path and thus improve dose deposition in liver...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27729992/salvage-local-therapy-for-radiation-recurrent-prostate-cancer-where-are-we
#18
Romuald Zdrojowy, Janusz Dembowski, Bartosz Małkiewicz, Krzysztof Tupikowski, Wojciech Krajewski
INTRODUCTION: Prostate cancer is the most frequent cancer among males in Europe and a leading cause of cancer deaths, with similar proportion in other developed countries. For more than twenty years, external-beam radiation therapy, alongside with radical prostatectomy, has been used as a primary radical therapeutic approach for localized prostate cancer. Yet, EBRT failures relate to 22-69% following curative radiotherapy (± androgen deprivation therapy). Additionally, a proportion of these men will have a biopsy-proven local recurrence...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27720531/focal-high-intensity-focused-ultrasound-of-unilateral-localized-prostate-cancer-a-prospective-multicentric-hemiablation-study-of-111-patients
#19
Pascal Rischmann, Albert Gelet, Benjamin Riche, Arnauld Villers, Gilles Pasticier, Pierre Bondil, Jean-Luc Jung, Hubert Bugel, Jacques Petit, Harry Toledano, Stéphane Mallick, Olivier Rouvière, Muriel Rabilloud, Hélène Tonoli-Catez, Sebastien Crouzet
BACKGROUND: Up to a third of patients with localized prostate cancer have unilateral disease that may be suitable for partial treatment with hemiablation. OBJECTIVE: To evaluate the ability of high intensity focused ultrasound (HIFU) to achieve local control of the tumor in patients with unilateral localized prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: The French Urological Association initiated a prospective IDEAL multi-institutional study (2009-2015), to evaluate HIFU-hemiablation as a primary treatment...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27694703/the-effect-of-temperature-dependent-tissue-parameters-on-acoustic-radiation-force-induced-displacements
#20
Visa Suomi, Yang Han, Elisa Konofagou, Robin O Cleveland
Multiple ultrasound elastography techniques rely on acoustic radiation force (ARF) in monitoring high-intensity focused ultrasound (HIFU) therapy. However, ARF is dependent on tissue attenuation and sound speed, both of which are also known to change with temperature making the therapy monitoring more challenging. Furthermore, the viscoelastic properties of tissue are also temperature dependent, which affects the displacements induced by ARF. The aim of this study is to quantify the temperature dependent changes in the acoustic and viscoelastic properties of liver and investigate their effect on ARF induced displacements by using both experimental methods and simulations...
October 21, 2016: Physics in Medicine and Biology
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