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https://www.readbyqxmd.com/read/29665583/clinical-effectiveness-and-potential-survival-benefit-of-us-guided-high-intensity-focused-ultrasound-therapy-in-patients-with-advanced-stage-pancreatic-cancer
#1
Milka Marinova, Hannah C Huxold, Jana Henseler, Martin Mücke, Rupert Conrad, Roman Rolke, Hojjat Ahmadzadehfar, Maximilian Rauch, Rolf Fimmers, Guido Luechters, Henning Cuhls, Lukas Radbruch, Hans H Schild, Holger Strunk
PURPOSE:  Pancreatic cancer (PaC) is a life-limiting tumor with a wide range of incapacitating symptoms such as cancer pain in more than 80 % of patients. This prospective interventional study addresses the clinical effectiveness of ultrasound-guided high-intensity focused ultrasound (HIFU) treatment for patients with advanced-stage PaC, including pain perception, tumor size and survival benefit. MATERIALS AND METHODS:  50 patients with late-stage PaC underwent HIFU...
April 17, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29664243/new-technologies-and-techniques-for-prostate-cancer-focal-therapy-a-review-of-the-current-literature
#2
Estefanía Linares-Espinós, Arie Carneiro, Juan I Martínez-Salamanca, Fernando Bianco, Adalberto Castro-Alfaro, Xavier Cathelineau, Massimo Valerio, Rafael Sanchez-Salas
BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search to those with a minimum of 12 months of follow-up...
April 16, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29660918/contrast-enhanced-ultrasound-ceus-with-mri-image-fusion-for-monitoring-focal-therapy-of-prostate-cancer-with-high-intensity-focused-ultrasound-hifu-1
#3
M Apfelbeck, D-A Clevert, J Ricke, C Stief, B Schlenker
INTRODUCTION: Reduced acceptance of radical prostatectomy in patients with low risk or intermediate risk prostate cancer has significantly changed treatment strategies in prostate cancer (PCa) during the last years. Focal therapy of the prostate with high intensity focused ultrasound (HIFU) is an organ-preserving treatment for prostate cancer with less impairment of health-related quality of life. Follow-up after HIFU therapy by imaging modalities remains a major problem as eg. MRI performs poorly...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29652130/in-vivo-targeted-responsive-and-synergistic-cancer-nanotheranostics-by-mri-guided-synergistic-hifu-ablation-and-chemotherapy
#4
Hailin Tang, Yuan Guo, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran, Yu Chen
As one of the most representative non-invasive therapeutic modalities, high-intensity focused ultrasound (HIFU) has shown the great promise for cancer therapy, but its low therapeutic efficacy and biosafety significantly hinder the further extensive clinical translation and application. In this work, we report on the construction of a multifunctional theranostic nanoplatform to synergistically enhance the HIFU-therapeutic efficacy based on nanomedicine. A targeted and temperature-responsive theranostic nanoplatform (PFH/DOX@PLGA/Fe3O4-FA) has been designed and fabricated for efficient ultrasound/magnetic resonance dual-modality imaging-guided HIFU/chemo synergistic therapy...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29651823/weak-light-emission-of-soft-tissues-induced-by-heating
#5
Antonello E Spinelli, Giovanni Durando, Federico Boschi
The main goal of this work is to show that soft tissue interaction with high-intensity focused ultrasound (HIFU) or direct heating leads to a weak light emission detectable using a small animal optical imaging system. Our results show that the luminescence signal is detectable after 30 min of heating, resembling the time scale of delayed luminescence. The imaging of a soft tissue after heating it using an HIFU field shows that the luminescence pattern closely matches the shape of the cone typical of the HIFU beam...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29644788/high-intensity-focused-ultrasound-treatment-after-cryolipolysis-may-be-used-to-reduce-pain-two-case-report
#6
Eun Jung Ko, Hyun Jung Kwon, Tae-Rin Kwon, Sun Young Choi, Kwang Ho Yoo, Beom Joon Kim
In recent years, interest in body sculpting has increased and various technologies have been used and developed. In the present study, we assessed the efficacy and safety of combination treatment using high-intensity focused ultrasound (HIFU) and cryolipolysis. The findings show that not only HIFU but also combination treatments are safe and well-tolerated options for the treatment of central abdominal subcutaneous adipose tissue (SAT). Interestingly, the pain associated with HIFU when it was performed after cryolipolysis was significantly reduced...
April 11, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29628611/updates-on-mr-guided-focused-ultrasound-for-symptomatic-uterine-fibroids
#7
REVIEW
Divya Sridhar, Maureen P Kohi
Magnetic-resonance-guided focused ultrasound (MRgFUS), also called high-intensity focused ultrasound (HIFU) is an effective, noninvasive uterine-preserving treatment for symptomatic uterine fibroids. As the use of this therapeutic modality is not yet widespread, it may remain unfamiliar to many interventional radiologists. The purpose of this review is to discuss MRgFUS, including technology, patient selection, technique, outcomes, complications, and recent data on fertility and comparative effectiveness.
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29610092/method-for-designing-multielement-fully-populated-random-phased-arrays-for-ultrasound-surgery-applications
#8
Pavel B Rosnitskiy, Boris A Vysokanov, Leonid R Gavrilov, Oleg A Sapozhnikov, Vera A Khokhlova
Maximizing the power of multielement phased arrays is a critical factor for high-intensity focused ultrasound (HIFU) applications such as histotripsy and transcostal sonications. This can be achieved by a tight packing of the array elements. Good electronic focusing capabilities are also required. Currently used quasi-random arrays with a relatively low filling factor of about 60% have this focusing ability. Here, a novel method of designing random HIFU arrays with the maximum possible filling factor (100% if no gaps between elements needed in practice are introduced) and polygonal elements of equal area and slightly different shapes based on the capacity-constrained tessellation is described...
April 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29609034/magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-is-a-non-invasive-treatment-modality-for-patients-with-abdominal-wall-endometriosis
#9
Bertine L Stehouwer, Manon N G Braat, Sebastiaan Veersema
Two females (29 and 35 years of age) presented with an abdominal wall mass in close proximity to a caesarean scar. The main complaints consisted of pain at the site of the mass, with catamenial exacerbations. Clinical and imaging findings were consistent with abdominal wall endometriosis in both cases. First, hormonal treatment was started, which proved unsuccessful. Typically at this point the proposed treatment would be wide-surgical excision. Alternatively, MR-HIFU treatment was offered with the goal to diminish pain complaints non-invasively...
March 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29588854/experimental-study-of-beam-distortion-due-to-fiducial-markers-during-salvage-hifu-in-the-prostate
#10
Marina Bakaric, Eleanor Martin, Panayiotis S Georgiou, Benjamin T Cox, Heather Payne, Bradley E Treeby
Background: Prostate cancer is frequently treated using external beam radiation therapy (EBRT). Prior to therapy, the prostate is commonly implanted with a small number of permanent fiducial markers used to monitor the position of the prostate during therapy. In the case of local cancer recurrence, high-intensity focused ultrasound (HIFU) provides a non-invasive salvage treatment option. However, the impact of the fiducial markers on HIFU treatment has not been thoroughly studied to date...
2018: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29556769/sequential-high-intensity-focused-ultrasound-hifu-ablation-in-the-treatment-of-benign-multinodular-goitre-an-observational-retrospective-study
#11
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
OBJECTIVES: Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation. METHODS: One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups...
March 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29555380/minimally-invasive-treatment-of-adenomyosis
#12
REVIEW
Margit Dueholm
The aim of the present review is to give a comprehensive overview of minimal invasive treatment options and suggest a minimally invasive approach in women with adenomyosis (AD). A review of relevant literature on medical and surgical treatment options is performed. Surgical options include endometrial ablation, hysteroscopic endometrial and adenomyoma resection, laparoscopic resection of AD, high-intensity focused ultrasonography (HIFU), and uterine artery embolization (UAE). This review summarizes treatment strategies for the management of AD and highlights the present lack of knowledge, which makes suggestions of evidence-based treatment difficult...
February 15, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29525455/transluminal-approach-with-bubble-seeded-histotripsy-for-cancer-treatment-with-ultrasonic-mechanical-effects
#13
Reiko Ashida, Ken-Ichi Kawabata, Takashi Maruoka, Kazuhiro Yamanaka, Hideki Yoshikawa, Tatsuya Ioka, Kazuhiro Katayama, Sachiko Tanaka
Bubble-seeded histotripsy (BSH) is a newly developed ultrasound-based mechanical fractionation technique using locally injected phase change nanodroplets (PCNDs) as sensitizers. The PCNDs are a kind of microbubble precursor compressed into submicron-size in droplets form, which were designed for local administration and will expand into microbubbles under ultrasound exposure. Previously, we reported that a combination of PCNDs injection and pulsed high-intensity focused ultrasound (pHIFU) with an acoustic intensity as low as about 3 kW/cm2 at 1...
March 7, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29525424/magnetic-resonance-imaging-parameters-in-predicting-the-treatment-outcome-of-high-intensity-focused-ultrasound-ablation-of-uterine-fibroids-with-an-immediate-nonperfused-volume-ratio-of-at-least-90
#14
Bilgin Keserci, Nguyen Minh Duc
RATIONALE AND OBJECTIVES: We aimed to investigate the role of magnetic resonance imaging parameters in predicting the treatment outcome of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids with a nonperfused volume (NPV) ratio of at least 90%. MATERIAL AND METHODS: A total of 120 women who underwent HIFU treatment were divided into groups 1 (n = 72) and 2 (n = 48), comprising patients with an NPV ratio of at least 90% and less than 90%, respectively...
March 7, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29525229/automated-geometric-optimization-for-robotic-hifu-treatment-of-liver-tumors
#15
Tom Williamson, Scott Everitt, Sunita Chauhan
BACKGROUND: High intensity focused ultrasound (HIFU) represents a non-invasive method for the destruction of cancerous tissue within the body. Heating of targeted tissue by focused ultrasound transducers results in the creation of ellipsoidal lesions at the target site, the locations of which can have a significant impact on treatment outcomes. Towards this end, this work describes a method for the optimization of lesion positions within arbitrary tumors, with specific anatomical constraints...
February 26, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29506421/factors-influencing-thermal-injury-to-skin-and-abdominal-wall-structures-in-hifu-ablation-of-uterine-fibroids
#16
Na Yin, Liang Hu, Zhi-Bo Xiao, Chang Liu, Wen-Zhi Chen, Neil Roberts, Jin-Yun Chen, Zhi-Biao Wang
OBJECTIVE: To investigate the factors which may cause thermal injury of abdominal wall structures in ultrasound-guided high-intensity focussed ultrasound (USgHIFU) ablation of uterine fibroids. METHOD: A total of 892 patients with uterine fibroids diagnosed on contrast-enhanced magnetic resonance imaging (MRI) scans received HIFU ablation and follow-up MRI scanning. After therapy, thermal injury to the skin was assessed via measurement of skin redness, blisters, subcutaneous nodules and to the abdominal wall structures via measurement of signal intensity on T2-weighted MRI images...
March 5, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29501713/titanised-transobturator-sling-placement-for-male-stress-urinary-incontinence-using-an-inside-out-single-incision-technique-minimum-12-months-follow-up-study
#17
Emilio Sacco, Carlo Gandi, Luigi Vaccarella, Salvatore Recupero, Marco Racioppi, Francesco Pinto, Angelo Totaro, Nazario Foschi, Giuseppe Palermo, Francesco Pierconti, Pierfrancesco Bassi
OBJECTIVE: To evaluate prospectively midterm outcomes of a new titanium-coated fixed polypropylene sling for male stress urinary incontinence. MATERIALS AND METHODS: From 01/2013 to 06/2016, 44 consecutive patients with incontinence caused by radical prostatectomy (39) or TURP (5) underwent transobturator two-arm titanium-coated sling (TiLOOP Male® ) implantation with an inside-out, single-incision technique, leaving the bulbourethral muscle in place. Patients have been assessed postoperatively with uroflowmetry, pad count, ICIQ-SF, IIQ-7, PGI-I, OABq, IPSS, satisfaction (yes/no)...
March 1, 2018: Urology
https://www.readbyqxmd.com/read/29496981/advanced-ultrasound-technologies-for-diagnosis-and-therapy
#18
Anne Rix, Wiltrud Lederle, Benjamin Theek, Twan Lammers, Chrit Moonen, Georg Schmitz, Fabian Kiessling
Ultrasound is among the most rapidly advancing imaging techniques. Functional methods such as elastography have been clinically introduced, and tissue characterization is improved by contrast-enhanced scans. Here, novel super-resolution techniques provide unique morphological and functional insights into tissue vascularisation. Functional analyses are complemented with molecular ultrasound imaging, to visualize markers of inflammation and angiogenesis. The full potential of diagnostic ultrasound may become apparent by integrating these multiple imaging features in radiomics approaches...
March 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29483853/minimally-invasive-procedures-in-the-management-of-uterine-fibroids
#19
REVIEW
Piotr Szkodziak, Filip Szkodziak, Kamila Trzeciak, Piotr Czuczwar
Uterine fibroids are benign uterine tumors. In women during the reproductive period, uterine fibroids occur in about 25%, whereas after this time, they are observed in more than 40% of women. In the majority of women (about 20-50%), such tumors do not cause discomfort and do not require treatment. Asymptomatic uterine fibroids usually undergo only regular medical control, whereas symptomatic fibroids are an indication for treatment. Current treatment methods include surgical, pharmacological and minimally invasive treatment...
December 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29453658/high-intensity-focused-ultrasound-hifu-therapy-for-benign-thyroid-nodules-without-anesthesia-or-sedation
#20
Pierpaolo Trimboli, Fabiano Bini, Franco Marinozzi, Jung Hwan Baek, Luca Giovanella
BACKGROUND: Thermal ablation of thyroid nodules has gained momentum due to the possibility to avoid surgery. High-intensity focused ultrasound (HIFU) allows thermal treatment by energy ultrasound beam inside the targeted zone. Aim of our study was to evaluate the effects of HIFU treatment using Beamotion mode without anesthesia. METHODS: Since 2016, patients with normal thyroid function, benign thyroid nodules with diameter no larger than 4 cm, and presenting local discomfort and/or compressive symptoms were treated by HIFU...
February 16, 2018: Endocrine
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