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https://www.readbyqxmd.com/read/29454904/protective-effect-of-sodium-stearate-on-the-moisture-induced-deterioration-of-hygroscopic-spray-dried-powders
#1
Jiaqi Yu, Maria-Cristina Romeo, Alex A Cavallaro, Hak-Kim Chan
Amorphous powders are thermodynamically unstable, significantly impacting the processing, storage and performance of a product. Therefore, stabilization of the amorphous contents is in demand. In this study, disodium cromoglycate (DSCG) powder was chosen as a model drug because it is amorphous and highly hygroscopic after spray drying. Sodium stearate (NaSt) was co-spray dried with DSCG at various concentrations (10, 50 and 90% w/w) to investigate its effect against moisture-induced deterioration on the in vitro aerosolization performance of DSCG...
February 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29454062/laser-assisted-delivery-of-synergistic-combination-chemotherapy-in-in-vivo-skin
#2
Emily Wenande, Joshua Tam, Brijesh Bhayana, Steven Kyle Schlosser, Emily Ishak, William A Farinelli, Agata Chlopik, Mai P Hoang, Omar R Pinkhasov, Peter Caravan, R Rox Anderson, Merete Haedersdal
The effectiveness of topical drugs for treatment of non-melanoma skin cancer is greatly reduced by insufficient penetration to deep skin layers. Ablative fractional lasers (AFLs) are known to enhance topical drug uptake by generating narrow microchannels through the skin, but information on AFL-drug delivery in in vivo conditions is limited. In this study, we examined pharmacokinetics, biodistribution and toxicity of two synergistic chemotherapy agents, cisplatin and 5-fluorouracil (5-FU), following AFL-assisted delivery alone or in combination in in vivo porcine skin...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29452045/successful-treatment-of-schamberg-s-disease-with-fractional-non-ablative-1540-nm-erbium-glass-laser
#3
Yuval Hilerowicz, Eli Sprecher, Andrea Gat, Ofir Artzi
Schamberg's disease is one of the pigmented purpuric dermatoses (PPD). PPD encompass a large and heterogeneous group of dermatologic disorders featuring purpuric lesions often located on the lower limbs. The various forms of PPD are notoriously known to be resistant to treatment. Fractional photothermolysis has been described as a successful and safe method to induce dermal remodeling. We report three patients with Schamberg's disease who were successfully treated with 4 monthly sessions of fractional non-ablative 1540 nm erbium:glass laser, with resolution of their purpuric pigmented rash lasting up to 9 months after the last treatment session...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29452017/fractional-non-ablative-laser-assisted-drug-delivery-leads-to-improvement-in-male-and-female-pattern-hair-loss
#4
Ana Carina Junqueira Bertin, Adriana Vilarinho, Ana Lúcia Ariano Junqueira
Androgenetic alopecia, also known as male and female pattern hair loss, is a very prevalent condition; however, approved therapeutic options are limited. Fractionated laser has been proposed to assist in penetration of topical medications to the cutaneous tissue. We present four cases of androgenetic alopecia that underwent treatment with a non-ablative erbium glass fractional laser followed by the application of topical finasteride 0,05% and growth factors including basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and copper peptide 1%...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29451290/high-temperature-pyrolysis-of-2-methyl-furan
#5
R S Tranter, P T Lynch, J B Randazzo, J P A Lockhart, X Chen, C F Goldsmith
The dissociation of 2-methyl furan at high temperatures has been studied in a combined experimental and theoretical approach to elucidate the details of this multi-channel unimolecular reaction. Laser schlieren densitometry studies were performed in a diaphragmless shock tube over the range 1600 < T < 2300 K and three pressures 60, 120 and 240 Torr. The theoretical study identified many reaction paths, most of which are initiated by the formation of carbenes. Of these paths, five account for 99% consumption of 2MF, and three account for 95% consumption...
February 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29448838/novel-methotrexate-soft-nanocarrier-fractional-erbium-yag-laser-combination-for-clinical-treatment-of-plaque-psoriasis
#6
Shahenda A Ramez, Mona M Soliman, Maha Fadel, Faisal Nour El-Deen, Maha Nasr, Eman R Youness, Dalea M Aboel-Fadl
Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects, therefore the development of a customized topical treatment modality for psoriasis would be an interesting alternative to systemic delivery. The therapeutic modality explored in this article was the comparative treatment of psoriatic patients using nanoparticulated methotrexate in the form of jojoba oil-based microemulsion with or without fractional erbium YAG laser...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#7
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29440233/comprehensive-characterisation-of-compartment-specific-long-non-coding-rnas-associated-with-pancreatic-ductal-adenocarcinoma
#8
Luis Arnes, Zhaoqi Liu, Jiguang Wang, Hans Carlo Maurer, Irina Sagalovskiy, Marta Sanchez-Martin, Nikhil Bommakanti, Diana C Garofalo, Dina A Balderes, Lori Sussel, Kenneth P Olive, Raul Rabadan
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. DESIGN: We developed a computational framework to reconstruct the non-coding transcriptome from cross-sectional RNA-Seq, integrating somatic copy number alterations (SCNA), common germline variants associated to PDA risk and clinical outcome...
February 10, 2018: Gut
https://www.readbyqxmd.com/read/29438465/does-stromal-vascular-fraction-ensure-a-higher-survival-in-autologous-fat-grafting-for-breast-augmentation-a-volumetric-study-using-3-dimensional-laser-scanning
#9
Cheng-Hung Chiu
Background: Cell-assisted lipotransfer (CAL) has been considered a promising technique for promoting adipogenesis and angiogenesis in fat grafts. Objectives: The author sought to objectively analyze the change of breast volume in patients who underwent stromal vascular fraction (SVF)-enriched fat grafting for breast augmentation and compared the clinical results with those who underwent conventional fat grafting without SVF by using 3D laser scanning. Methods: From April 2015 to March 2016, 105 patients who underwent traditional fat grafting without SVF enrichment for breast augmentation were assigned to group A and served as the control...
February 9, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29437000/extraction-identification-and-biological-activities-of-saponins-in-sea-cucumber-pearsonothuria-graeffei
#10
Rafat Afifi Khattab, Mohamed Elbandy, Andrew Lawrence, Tim Paget, Jung Rae-Rho, Yaser S Binnaser, Imran Ali
AIM AND OBJECTIVE: Secondary metabolism in marine organisms produced a diversity of biological important natural compounds which are unpresented in terrestrial species. Sea cucumbers belong to the invertebrate Echinodermata and are famous for their nutraceutical, medical and food values. They are known for possession triterpenoid glycosides (saponins) with various ecological roles. The current work aimed to separate, identify and test various biological activities (anti-bacterial, antifungal, antileishmanial and anticancer properties) of saponins produced by the holothurian Pearsonothuria graeffei from the Red Sea, Egypt...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29431228/efficacy-of-mas063dp-lotion-vs-0-02-triamcinolone-acetonide-lotion-in-improving-post-ablative-fractional-co-2-laser-resurfacing-wound-healing-a-split-face-triple-blinded-randomized-controlled-trial
#11
Suparuj Lueangarun, Therdpong Tempark
Proven as effective acne scar treatment, ablative fractional carbon dioxide (AFCO 2 ) laser requires post-laser wound healing care. MAS063DP is a multicomponent nonsteroidal anti-inflammatory moisturizer for effective post-laser treatment. This study compares the efficacy of MAS063DP and 0.02% triamcinolone acetonide (TA) lotion for post-laser wound healing and complications. A split-face, triple-blinded, clinical study was performed in 16 patients, aged 20-50 years, receiving AFCO 2 on both sides of the face, with MAS063DP on one side and 0...
February 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29419914/early-laser-intervention-to-reduce-scar-formation-a-systematic-review
#12
REVIEW
K Karmisholt, A Haerskjold, T Karlsmark, J Waibel, U Paasch, M Haedersdal
The ability of laser treatment to affect wound healing and subsequently minimize scar formation has been investigated in recent years. However, no systematic review links these clinical trials. The aim of this study is to systematically review and evaluate clinical evidence for early laser intervention to reduce scar formation in studies where laser treatment were introduced less than 3 months after wounding. We searched PubMed using relevant key words in June 2017. Titles, abstracts and articles were sorted according to inclusion and exclusion criteria...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29416062/compressive-sensing-for-spatial-and-spectral-flame-diagnostics
#13
David J Starling, Joseph Ranalli
Combustion research requires the use of state of the art diagnostic tools, including high energy lasers and gated, cooled CCDs. However, these tools may present a cost barrier for laboratories with limited resources. While the cost of high energy lasers and low-noise cameras continues to decline, new imaging technologies are being developed to address both cost and complexity. In this paper, we analyze the use of compressive sensing for flame diagnostics by reconstructing Raman images and calculating mole fractions as a function of radial depth for a highly strained, N2-H2 diffusion flame...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414897/real-time-and-meter-scale-absolute-distance-measurement-by-frequency-comb-referenced-multi-wavelength-interferometry
#14
Guochao Wang, Lilong Tan, Shuhua Yan
We report on a frequency-comb-referenced absolute interferometer which instantly measures long distance by integrating multi-wavelength interferometry with direct synthetic wavelength interferometry. The reported interferometer utilizes four different wavelengths, simultaneously calibrated to the frequency comb of a femtosecond laser, to implement subwavelength distance measurement, while direct synthetic wavelength interferometry is elaborately introduced by launching a fifth wavelength to extend a non-ambiguous range for meter-scale measurement...
February 7, 2018: Sensors
https://www.readbyqxmd.com/read/29414578/quantitative-measurement-of-carbon-isotopic-composition-in-co2-gas-reservoir-by-micro-laser-raman-spectroscopy
#15
Jiajia Li, Rongxi Li, Bangsheng Zhao, Hui Guo, Shuan Zhang, Jinghua Cheng, Xiaoli Wu
The use of Micro-Laser Raman spectroscopy technology for quantitatively determining gas carbon isotope composition is presented. In this study, 12CO2 and 13CO2 were mixed with N2 at various molar fraction ratios to obtain Raman quantification factors (F12CO2 and F13CO2), which provide a theoretical basis for calculating the δ13C value. And the corresponding values were 0.523 (0<C12CO2/CN2<2) and 1.11998 (0<C13CO2/CN2<1.5) respectively. It has shown that the representative Raman peak area can be used for the determination of δ13C values within the relative errors range of 0...
February 1, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29414467/continuous-functionally-graded-porous-titanium-scaffolds-manufactured-by-selective-laser-melting-for-bone-implants
#16
Changjun Han, Yan Li, Qian Wang, Shifeng Wen, Qingsong Wei, Chunze Yan, Liang Hao, Jie Liu, Yusheng Shi
A significant requirement for a bone implant is to replicate the functional gradient across the bone to mimic the localization change in stiffness. In this work, continuous functionally graded porous scaffolds (FGPSs) based on the Schwartz diamond unit cell with a wide range of graded volume fraction were manufactured by selective laser melting (SLM). The micro-topology, strut dimension characterization and effect of graded volume fraction on the mechanical properties of SLM-processed FGPSs were systematically investigated...
January 12, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29410753/the-effects-of-fractional-co2-laser-nano-hydroxyapatite-and-mi-paste-on-mechanical-properties-of-bovine-enamel-after-bleaching
#17
Horieh Moosavi, Narjes Hakimi
Background: This study investigated the effect of post bleaching treatments to the change of enamel elastic modulus and microhardness after dental bleaching in- vitro. Material and Methods: Fifty bovine incisor slab were randomly assigned into five groups (n=10). The samples were bleached for three times; 20 minutes each time, by 40% hydrogen peroxide. Next it was applied fractional CO2 laser for two minutes, Nano- hydroxy apatite (N-HA) and MI-paste for 7 days and 2 minutes per day...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29406425/vulvar-and-vaginal-fractional-co2-laser-treatments-for-genitourinary-syndrome-of-menopause
#18
Lauren F Streicher
Many healthcare providers are offering women treatment with the fractionated CO2 laser for a myriad of gynecologic issues, including genitourinary syndrome of menopause (GSM). Because existing data are limited, providing guidance is challenging. This Practice Pearl addresses what we know and don't know about the use of the fractionated CO2 laser for the treatment of GSM.
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29406374/cerebral-oxygen-metabolism-before-and-after-rbc-transfusion-in-infants-following-major-surgical-procedures
#19
Felix Neunhoeffer, Michael Hofbeck, Martin Ulrich Schuhmann, Jörg Fuchs, Christian Schlensak, Martin Esslinger, Ines Gerbig, Vanya Icheva, Ellen Heimberg, Matthias Kumpf, Jörg Michel
OBJECTIVE: Although infants following major surgery frequently require RBC transfusions, there is still controversy concerning the best definition for requirement of transfusion in the individual patient. The aim of this study was to determine the impact of RBC transfusion on cerebral oxygen metabolism in noncardiac and cardiac postsurgical infants. DESIGN: Prospective observational cohort study. SETTING: Pediatric critical care unit of a tertiary referral center...
February 5, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29405049/delivery-and-reveal-of-localization-of-upconversion-luminescent-microparticles-and-quantum-dots-in-the-skin-in-vivo-by-fractional-laser-microablation-multimodal-imaging-and-optical-clearing
#20
Elena K Volkova, Irina Yu Yanina, Elina A Genina, Alexey N Bashkatov, Julia G Konyukhova, Alexey P Popov, Elena S Speranskaya, Alla B Bucharskaya, Nikita A Navolokin, Irina Yu Goryacheva, Vyacheslav I Kochubey, Gleb B Sukhorukov, Igor V Meglinski, Valery V Tuchin
Delivery and spatial localization of upconversion luminescent microparticles [Y2O3:Yb, Er] (mean size ∼1.6  μm) and quantum dots (QDs) (CuInS2/ZnS nanoparticles coated with polyethylene glycol-based amphiphilic polymer, mean size ∼20  nm) inside rat skin was studied in vivo using a multimodal optical imaging approach. The particles were embedded into the skin dermis to the depth from 300 to 500  μm through microchannels performed by fractional laser microablation. Low-frequency ultrasound was applied to enhance penetration of the particles into the skin...
February 2018: Journal of Biomedical Optics
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