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Fractionated laser

Christopher Zachary
No abstract text is available yet for this article.
December 14, 2017: Lasers in Surgery and Medicine
Emily Wenande, Andrés Már Erlendsson, Merete Haedersdal
Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures. Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT...
December 2017: Seminars in Cutaneous Medicine and Surgery
Shilpi Khetarpal, Urvashi Kaw, Jeffrey S Dover, Kenneth A Arndt
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can be used to revitalize and restore damaged skin in atrophic and hypertrophic scars. The most commonly used lasers are the pulsed-dye laser (PDL) and fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
Emil A Tanghetti, Kristina Andrea Hoffmann, Klaus Hoffmann
This review describes the use of picosecond lasers for the treatment of tattoos, pigmented lesions, scars, and their use in rejuvenation. These devices have delivered enhanced efficacy for the treatment of tattoos and pigmented lesions when compared to the older 40-50 nanosecond devices. The fractional delivery with the picosecond devices have opened up a new method of rejuvenation for photodamaged skin and the treatment of scars. The delivery of these high-energy short pulses have created zones of injury in the skin referred to as areas of laser-induced optical breakdown...
December 2017: Seminars in Cutaneous Medicine and Surgery
Deirdre Connolly, Laura Schilling, Nazanin Saedi
The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
Haosen Shang, Xiaogang Zhang, Shengnan Zhang, Duo Pan, Haijun Chen, Jingbiao Chen
We implement a miniaturized calcium beam optical frequency standard using specially-designed fully-sealed vacuum tube, and realize the comparison with another calcium beam optical clock whose vacuum tube is sealed by flanges. The electron shelving detection method is adopted to improve the signal-to-noise ratio of the clock transition spectroscopy, and the readout laser is locked by modulation-free frequency locking technology based on Doppler effect. Injection locking is carried out to boost the power of the 657 nm master clock transition laser, thus ensuring the comparison...
November 27, 2017: Optics Express
Andrew Flood, Nazir P Kherani
The effect of various design and material parameters on the efficiency of stimulated emission-based luminescent solar concentrators (SELSCs) is studied numerically using a 4-level luminescent material containing concentrator. It is shown that the most efficient SELSCs have emission wavelengths of 1.5-1.8 µm, with a strong dependence on the Stokes shift. Depending on the parameters of the system, spontaneous emission is shown to nevertheless account for a significant fraction of potential energy generation...
November 27, 2017: Optics Express
L Schmitt, S Huth, P M Amann, Y Marquardt, R Heise, K Fietkau, L Huth, T Steiner, F Hölzle, J M Baron
Molecular effects of various ablative and non-ablative laser treatments on human skin cells-especially primary effects on epidermal keratinocytes and dermal fibroblasts-are not yet fully understood. We present the first study addressing molecular effects of fractional non-sequential ultrapulsed CO2 laser treatment using a 3D skin model that allows standardized investigations of time-dependent molecular changes ex vivo. While histological examination was performed to assess morphological changes, we utilized gene expression profiling using microarray and qRT-PCR analyses to identify molecular effects of laser treatment...
December 7, 2017: Lasers in Medical Science
Jiří Šalplachta, Marie Horká, Filip Růžička, Karel Šlais
This study describes a new method for simultaneous identification of uropathogens in the case of polybacterial urinary tract infections. The method utilizes recently developed preparative isoelectric focusing (IEF) in cellulose-based separation medium with a subsequent analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Preparative IEF was successfully used for both purification and separation of bacteria, Escherichia coli (pI 4.6) and Staphylococcus aureus (pI 3...
December 2, 2017: Journal of Chromatography. A
Tobias Beirau, Dawid Murawski, Harald Behrens, Ekhard K H Salje, Lee A Groat, Ronny Kaden, Herbert Pöllmann, Ulrich Bismayer
In situ temperature-dependent laser-induced photoluminescence and dielectric measurements provide new evidence for the local occurrence of the α → β phase transition near 500 K in the preserved crystalline parts of natural radiation-damaged titanite (sample E2335 with ~ 24% amorphous fraction, containing Fe and Al impurities). Photoluminescence spectroscopic measurements show an anomaly in the vicinity of 500 K. The temperature-dependent evolution of the real part of the electrical conductivity (σ) and the real (ε̍) and the imaginary (ε̎) part of the complex dielectric permittivity (ε*) of titanite have been measured at various AC frequencies (~ 1...
December 7, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Ryusuke Irie, Koji Kamagata, Aurelien Kerever, Ryo Ueda, Suguru Yokosawa, Yosuke Otake, Hisaaki Ochi, Hidekazu Yoshizawa, Ayato Hayashi, Kazuhiko Tagawa, Hitoshi Okazawa, Kohske Takahashi, Kanako Sato, Masaaki Hori, Eri Arikawa-Hirasawa, Shigeki Aoki
PURPOSE: Diffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain. METHODS: One thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
Irshad S Sharafutdinov, Elena Y Trizna, Diana R Baidamshina, Maria N Ryzhikova, Regina R Sibgatullina, Alsu M Khabibrakhmanova, Liliya Z Latypova, Almira R Kurbangalieva, Elvira V Rozhina, Mareike Klinger-Strobel, Rawil F Fakhrullin, Mathias W Pletz, Mikhail I Bogachev, Airat R Kayumov, Oliwia Makarewicz
The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety...
2017: Frontiers in Microbiology
Yueqiang Yu, Yanling Guo, Ting Jiang, Jian Li, Kaiyi Jiang, Hui Zhang
To alleviate resource shortage, reduce the cost of materials consumption and the pollution of agricultural and forestry waste, walnut shell composites (WSPC) consisting of walnut shell as additive and copolyester hot melt adhesive (Co-PES) as binder was developed as the feedstock of selective laser sintering (SLS). WSPC parts with different ingredient proportions were fabricated by SLS and processed through after-treatment technology. The density, mechanical properties and surface quality of WSPC parts before and after post processing were analyzed via formula method, mechanical test and scanning electron microscopy (SEM), respectively...
December 2, 2017: Materials
Robert Naumann, Florian Lehmann, Martin Goez
We present the first working system for accessing and utilizing laboratory-scale concentrations of hydrated electrons by photoredox catalysis with a green light-emitting diode (LED). Decisive are micellar compartmentalization and photon pooling in an intermediate that decays with second-order kinetics. The only consumable is the nontoxic and bioavailable vitamin C. A turnover number of 1380 shows the LED method to be on par with electron generation by high-power pulsed lasers, but at a fraction of the cost...
December 5, 2017: Angewandte Chemie
Parhom Towfighi, Jacob Shaw, Tara Sigdel
In order to simplify a complex mixture of soluble proteins from tissues, a protocol to fractionate samples prior to two-dimensional (2D) gel electrophoresis has been developed. These methods involve the use of DEAE-Sepharose, SP-Sepharose, and phenyl Sepharose chromatographic columns and the fractionation of the protein mixtures based on differential anionic, cationic, and hydrophobic properties of the proteins, respectively. Fractionation of the soluble proteins with DEAE-Sepharose can result in an increase in the number of detectable 2D gel spots...
December 2, 2017: Methods in Molecular Biology
Christina A Banzhaf, Lynlee L Lin, Nhung Dang, Michael Freeman, Merete Haedersdal, Tarl W Prow
BACKGROUND: Ablative fractional laser (AFXL) is an acknowledged technique to increase uptake of topical agents in skin. Micro thermal ablation zones (MAZs) consist of ablated vertical channels surrounded by a coagulation zone (CZ). Laser scanning confocal microscopy (LSCM) images individual MAZs at 733 nm (reflectance confocal microscopy (RCM)). Further, LSCM can image sodium fluorescein (NaF) fluorescence with 488 nm excitation (fluorescence confocal microcopy (FCM)), a small hydrophilic test molecule (370 MW, log P -1...
November 29, 2017: Lasers in Surgery and Medicine
(no author information available yet)
A method for measuring the nonlinearity of laser interferometer using optical frequency tuning technique is presented in this paper. The basic principle of this method is to make the fractional part of an interference fringe change by tuning the laser frequency and determining the nonlinearity of interferometer by comparing the fractional fringe change measured by the interferometer to that calculated from the laser frequency change. An experimental interferometric system with a wavelength tunable laser source is set up and the nonlinearity of the interferometer is measured...
November 24, 2017: Sensors
Klaus Hopster, Liza Wittenberg-Voges, Florian Geburek, Charlotte Hopster-Iversen, Sabine B R Kästner
BACKGROUND: Aim of this prospective experimental study was to assess effects of systemic hypoxemia and hypovolemia on global and gastrointestinal oxygenation and perfusion in anesthetized horses. Therefore, we anesthetized twelve systemically healthy warmblood horses using either xylazine or dexmedetomidine for premedication and midazolam and ketamine for induction. Anesthesia was maintained using isoflurane in oxygen with either xylazine or dexmedetomidine and horses were ventilated to normocapnia...
November 28, 2017: BMC Veterinary Research
Zhijian Kong, Xuanqing Wang, Qiumei Liu, Tuo Li, Xing Chen, Lifang Chai, Dongyang Liu, Qirong Shen
Different fractions during the 85-day windrow composting were characterized based on various parameters, such as physiochemical properties and hydrolytic enzyme activities; several technologies were used, including spectral scanning techniques, confocal laser scanning microscopy (CLSM) and 13C Nuclear Magnetic Resonance Spectroscopy (13C NMR). The evaluated parameters fluctuated strongly during the first 3 weeks which was the most active period of the composting process. The principal components analysis (PCA) results showed that four classes of the samples were clearly distinguishable, in which the physiochemical parameters were similar, and that the dynamics of the composting process was significantly influenced by C/N and moisture content...
November 25, 2017: Journal of Environmental Management
Syed Kashif Raza, Mahwish Saleem, Tahir Shamsi, M Iqbal Choudhary, Atta-Ur-Rahman, Syed Ghulam Musharraf
Acute myeloid leukaemia (AML) is a type of cancer affecting all ages but it is more common in adults, as compared to children. Recent advancements in proteomics and mass spectrometry tools, offer a comprehensive solution to study the molecular complexity of diseases, such as cancers. This study is focused on the proteomic profiling of AML in comparison to healthy control for which, a systematic 5D proteomic approach for the fractionation of pooled plasma samples was used. Methodology includes depletion of Top-7 abundant proteins, ZOOM-isoelectric focusing (ZOOM-IEF), two-dimensional gel electrophoresis (2-DGE), and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis followed by the validation of identified biomarker proteins using enzyme linked immunosorbent assay (ELISA)...
November 27, 2017: Scientific Reports
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