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https://www.readbyqxmd.com/read/28638810/common-malignant-cutaneous-conditions-among-albinos-in-kenya
#1
Seyed Emad Emadi, Andrew Juma Suleh, Farhang Babamahmoodi, Fatemeh Ahangarkani, Vanessa Betty Chelimo, Beatrice Mutai, Seyyed Reza Raeeskarami, Alireza Ghanadan, Seyed Naser Emadi
Background: Albinos in Africa are at constant risk of developing skin cancer due to the damage caused by ultra-violet exposure. This study identifies the common skin conditions among albinos in Kenya as a country located along the equator. Methods: In this descriptive study on albino patients who were admitted to Mbagathi District Hospital in Nairobi, Kenya the census method was used for sampling and a total of 151 albinos were registered. All necessary data including age, gender, type, site and the number of skin lesions were recorded...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28636260/lichenoid-keratosis-is-frequently-misdiagnosed-as-basal-cell-carcinoma
#2
D Maor, C Ondhia, L L Yu, J J Chan
Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis...
June 21, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28341252/correlation-between-digital-epiluminescence-microscopy-parameters-and-histopathological-changes-in-lentigo-maligna-and-solar-lentigo-a-dermoscopic-index-for-the-diagnosis-of-lentigo-maligna
#3
Giorgio Annessi, Riccardo Bono, Damiano Abeni
BACKGROUND: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult. OBJECTIVE: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation. METHODS: A total of 167 consecutive doubtful pigmented lesions of the head (105 LM and 62 SL/SK) were studied...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28329662/the-preneoplastic-genome-transcriptomic-drivers-of-squamous-cell-carcinoma-development
#4
Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV- driven Hairless mouse model. We performed RNA-seq and microRNA-seq on samples from both patients undergoing Mohs surgery and the mouse model...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28162852/the-role-of-immunosuppression-in-squamous-cell-carcinomas-arising-in-seborrheic-keratosis
#5
Ruzica Z Conic, Karl Napekoski, Heidi Schuetz, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
BACKGROUND: Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described. OBJECTIVE: To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions. METHODS: There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic specimens and medical records were reviewed...
June 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#6
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28131816/traf1-is-critical-for-dmba-solar-uvr-induced-skin-carcinogenesis
#7
Hiroyuki Yamamoto, Joohyun Ryu, Eli Min, Naomi Oi, Ruihua Bai, Tatyana A Zykova, Dong Hoon Yu, Kenji Moriyama, Ann M Bode, Zigang Dong
TRAF1 is a member of the TRAF protein family, which regulates the canonical and noncanonical NF-κB signaling cascades. Although aberrant TRAF1 expression in tumors has been reported, the role of TRAF1 remains elusive. Here, we report that TRAF1 is required for solar UV-induced skin carcinogenesis. Immunohistochemical analysis showed that TRAF1 expression is up-regulated in human actinic keratosis and squamous cell carcinoma. In vivo studies indicated that TRAF1 expression levels in mouse skin are induced by short-term solar UV irradiation, and a long-term skin carcinogenesis study showed that deletion of TRAF1 in mice results in a significant inhibition of skin tumor formation...
January 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28117489/rejuvenation-of-the-male-scalp-using-1-927%C3%A2-nm-non-ablative-fractional-thulium-fiber-laser
#8
Monica Boen, Monique J Vanaman Wilson, Mitchel P Goldman, Douglas C Wu
OBJECTIVE: The male scalp undergoes extensive photodamage due to a high prevalence of androgenic alopecia and exposure to ultraviolet radiation. This photodamage presents as solar lentigines, fine rhytides, and keratosis, and can prematurely age a patient. In this study, we demonstrate the safety and efficacy of the fractionated 1,927 nm thulium fiber laser using high density and high energy settings to achieve rejuvenation of the male scalp after a single treatment session. METHODS: Four male patients with Fitzpatrick skin types II-III and extensive photodamage on the scalp underwent one treatment with the fractional non-ablative 1,927 nm thulium fiber laser...
July 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28105724/intraepidermal-proliferation-of-merkel-cells-within-a-seborrheic-keratosis-merkel-cell-carcinoma-in-situ-or-merkel-cell-hyperplasia
#9
Jeanne McFalls, Lauren Okon, Sarah Cannon, Jason B Lee
Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation or a neoplastic process, namely Merkel cell carcinoma (MCC) in situ. The recent criteria that have been proffered to diagnose MCC in situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells. Most previously reported cases of MCC in situ have occurred within associated epithelial lesion that includes solar (actinic) keratosis and squamous-cell carcinoma in situ...
May 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27864996/skin-microtopography-as-a-measure-of-photoaging-and-risk-of-squamous-cell-carcinoma-of-the-skin-in-a-us-population
#10
Lawrence Fitzgerald Kuklinski, Michael Scot Zens, Ann E Perry, Adele C Green, Margaret R Karagas
BACKGROUND: Skin microtopography as a measure of photoaging is a noninvasive approach to measuring chronic ultraviolet radiation exposure and reflects the degree of dermal elastosis in populations of European descent in the subtropics. Less is known about the utility of this approach in populations at different latitudes, and whether it relates to skin cancer risk. METHODS: A population-based case-control study of 342 squamous cell carcinoma (SCC) cases and 331 age- and gender-matched controls were evaluated for histologic evidence of solar damage and severity of photoaging based on microtopography on a six-grade scale...
January 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27859308/resatorvid-based-pharmacological-antagonism-of-cutaneous-tlr4-blocks-uv-induced-nf-%C3%AE%C2%BAb-and-ap-1-signaling-in-keratinocytes-and-mouse-skin
#11
Jaroslav Janda, Nichole B Burkett, Karen Blohm-Mangone, Vivian Huang, Clara Curiel-Lewandrowski, David S Alberts, Emanuel F Petricoin, Valerie S Calvert, Janine Einspahr, Zigang Dong, Ann M Bode, Georg T Wondrak, Sally E Dickinson
Cutaneous exposure to solar ultraviolet (UV) radiation is a major causative factor in skin carcinogenesis, and improved molecular strategies for efficacious chemoprevention of nonmelanoma skin cancer (NMSC) are urgently needed. Toll-like receptor 4 (TLR4) signaling has been shown to drive skin inflammation, photoimmunosuppression, and chemical carcinogenesis. Here we have examined the feasibility of genetic and pharmacological antagonism targeting cutaneous TLR4 for the suppression of UV-induced NF-κB and AP-1 signaling in keratinocytes and mouse skin...
November 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27748266/imiquimod-induced-vitiligo-like-depigmentation-over-multiple-solar-keratosis-in-a-patient-with-vitiligo
#12
Naoki Oiso, Tomohiko Narita, Akira Kawada
No abstract text is available yet for this article.
February 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27741334/biological-effects-of-ingenol-mebutate-gel-in-moderate-to-severe-actinic-fields-assessed-by-reflectance-confocal-microscopy-a-phase-i-study
#13
RANDOMIZED CONTROLLED TRIAL
Martina Ulrich, Susanne Lange-Asschenfeldt, Kresten Skak, Torsten Skov, Marie Louise Østerdal, Hans-Joachim Röwert-Huber, John Robert Zibert, Eggert Stockfleth
Ingenol mebutate represents a topical treatment for fields with actinic keratosis (AK). The biological effects of ingenol mebutate in AK, subclinical (SC)-AK, and reference-skin were assessed and graded by in vivo reflectance confocal microscopy (RCM) and histology. Patients with AK and SC-AK lesions in one 25 cm2 field on hands or forearms, and with an area of reference skin on the inner upper arm, were included. The two fields were each treated with ingenol mebutate 0.05% gel (n=16), or vehicle (n=8), on 2 consecutive days; clinical and RCM assessments were performed on days 1, 2, 3, 8, and 57, and biopsies on day 3...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27680010/-skin-cancer-as-occupational-disease
#14
REVIEW
A Bauer
The incidence of epithelial skin neoplasms, such as squamous cell carcinoma and basal cell carcinoma is significantly increasing worldwide. Leisure time solar UV exposure is causative in the overwhelming majority of cases in the general population; however, occupational exposure is responsible for a certain percentage of cases. Employees with a relevant exposure to polycyclic aromatic hydrocarbons in soot, raw paraffin, coal tar, anthracene, pitch or similar substances, to sunlight in outdoor occupations as well as to arsenic and ionizing radiation have a significantly increased risk to develop occupational skin cancer compared to the general population...
November 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27636884/repeated-treatments-with-ingenol-mebutate-prevents-progression-of-uv-induced-photodamage-in-hairless-mice
#15
Andrés Már Erlendsson, Daniel Thaysen-Petersen, Christiane Bay, Andreas Hald, Kresten Skak, John Robert Zibert, Uwe Paasch, Hans Christian Wulf, Merete Haedersdal
BACKGROUND AND AIM: Ingenol mebutate (IngMeb) is an effective treatment for actinic keratosis. In this study, we hypothesized that repeated treatments with IngMeb may prevent progression of UV-induced photodamage, and that concurrent application of a corticosteroid may reduce IngMeb-induced local skin responses (LSR). METHODS: Hairless mice (n = 60; 3 groups of 20 mice) were irradiated with solar simulated ultraviolet radiation (UVR) throughout the study. Five single treatments with IngMeb were given at 4-week intervals (Days 21, 49, 77, 105, and 133)...
2016: PloS One
https://www.readbyqxmd.com/read/27593207/exposure-to-fine-particulate-matter-associated-with-senile-lentigo-in-chinese-women-a-cross-sectional-study
#16
F Peng, C-H Xue, S K Hwang, W-H Li, Z Chen, J-Z Zhang
BACKGROUND: Skin ageing especially senile lentigo directly affects self-esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines. OBJECTIVE: To investigate the association between fine particulate matter (PM2.5 ) and skin ageing, particularly senile lentigo and seborrheic keratosis...
February 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27574101/cross-species-identification-of-genomic-drivers-of-squamous-cell-carcinoma-development-across-preneoplastic-intermediates
#17
Vida Chitsazzadeh, Cristian Coarfa, Jennifer A Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H Adelmann, Grace Ching, Tran N Nguyen, Courtney Nicholas, Valencia D Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A Polansky, Hussein A Abbas, Kimal Rajapakshe, Adam Gower, Avrum Spira, Kyle R Covington, Weimin Xiao, Preethi Gunaratne, Curtis Pickering, Mitchell Frederick, Jeffrey N Myers, Li Shen, Hui Yao, Xiaoping Su, Ronald P Rapini, David A Wheeler, Ernest T Hawk, Elsa R Flores, Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition...
August 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27566079/baicalin-scavenged-reactive-oxygen-species-and-protected-human-keratinocytes-against-uvb-induced-cytotoxicity
#18
Wen-Shin Chang, En-Yuan Lin, Shih-Wei Hsu, Pei-Shin Hu, Chin-Liang Chuang, Cheng-Hsi Liao, Chun-Kai Fu, Chung-Hao Su, Chi-Li Gong, Chieh-Lun Hsiao, DA-Tian Bau, Chia-Wen Tsai
Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. In this study, we examined whether baicalin is also capable of protecting human keratinocytes from UVB irradiation...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27411692/new-perspectives-on-role-of-tumor-microenvironment-in-progression-of-cutaneous-squamous-cell-carcinoma
#19
REVIEW
Liisa Nissinen, Mehdi Farshchian, Pilvi Riihilä, Veli-Matti Kähäri
Epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing worldwide. Solar UV radiation is an important risk factor for cSCC and leads to genetic and epigenetic changes both in epidermal keratinocytes and dermal cells. Tumor cells in cutaneous cSCCs typically harbor several driver gene mutations, but epidermal keratinocytes in sun-exposed normal skin also contain mutations in these same genes. Therefore, alterations in the microenvironment of premalignant lesions are evidently required for their progression to invasive and metastatic cSCC...
September 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27299522/phosphodiesterase-type-5-inhibitors-and-risk-of-malignant-melanoma-matched-cohort-study-using-primary-care-data-from-the-uk-clinical-practice-research-datalink
#20
Anthony Matthews, Sinéad M Langan, Ian J Douglas, Liam Smeeth, Krishnan Bhaskaran
BACKGROUND: Laboratory evidence suggests that reduced phosphodiesterase type 5 (PDE5) expression increases the invasiveness of melanoma cells; hence, pharmacological inhibition of PDE5 could affect melanoma risk. Two major epidemiological studies have investigated this and come to differing conclusions. We therefore aimed to investigate whether PDE5 inhibitor use is associated with an increased risk of malignant melanoma, and whether any increase in risk is likely to represent a causal relationship...
June 2016: PLoS Medicine
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