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Biyao Shao, Bingtao Liu, Chenggang Yan
MiRNA-disease association is important to disease diagnosis and treatment. Prediction of miRNA-disease associations is receiving increasing attention. Using the huge number of known databases to predict potential associations between miRNAs and diseases is an important topic in the field of biology and medicine. In this paper, we propose a novel computational method of with Short Acyclic Connections in Heterogeneous Graph (SACMDA). SACMDA obtains AUCs of 0.8770 and 0.8368 during global and local leave-one-out cross validation, respectively...
April 11, 2018: Neuroinformatics
Katya Cuadros Carlesi, Kátia Grillo Padilha, Maria Cecília Toffoletto, Carlos Henriquez-Roldán, Monica Andrea Canales Juan
Objective: to identify the relationship between the workload of the nursing team and the occurrence of patient safety incidents linked to nursing care in a public hospital in Chile. Method: quantitative, analytical, cross-sectional research through review of medical records. The estimation of workload in Intensive Care Units (ICUs) was performed using the Therapeutic Interventions Scoring System (TISS-28) and for the other services, we used the nurse/patient and nursing assistant/patient ratios...
April 6, 2017: Revista Latino-americana de Enfermagem
Shumao Pang, Jun Jiang, Zhentai Lu, Xueli Li, Wei Yang, Meiyan Huang, Yu Zhang, Yanqiu Feng, Wenhua Huang, Qianjin Feng
We propose local linear mapping (LLM), a novel fusion framework for distance field (DF) to perform automatic hippocampus segmentation. A k-means cluster method is propose for constructing magnetic resonance (MR) and DF dictionaries. In LLM, we assume that the MR and DF samples are located on two nonlinear manifolds and the mapping from the MR manifold to the DF manifold is differentiable and locally linear. We combine the MR dictionary using local linear representation to present the test sample, and combine the DF dictionary using the corresponding coefficients derived from local linear representation procedure to predict the DF of the test sample...
April 3, 2017: Scientific Reports
Hanyu Jiang, Jie Chen, Ronghui Gao, Zixing Huang, Mingpeng Wu, Bin Song
PURPOSE: A meta-analysis was performed to assess the diagnostic performance of diffusion-weighted imaging (DWI) in liver fibrosis (LF) staging. METHODS: We conducted a comprehensive literature search to identify relevant articles. Diagnostic data were extracted for each METAVIR fibrosis stage (F0-F4). A bivariate binomial model was used to combine sensitivities and specificities. Summary receiver operating characteristics (SROC) curves were performed and areas under SROC curve (AUC) were calculated to indicate diagnostic accuracies...
February 2017: Abdominal Radiology
Peizhan Chen, Xiaohua Duan, Mian Li, Chao Huang, Jingquan Li, Ruiai Chu, Hao Ying, Haiyun Song, Xudong Jia, Qian Ba, Hui Wang
Cadmium has been defined as type I carcinogen for humans, but the underlying mechanisms of its carcinogenic activity and its influence on protein-protein interactions in cells are not fully elucidated. The aim of the current study was to evaluate, systematically, the carcinogenic activity of cadmium with systems biology approaches. From a literature search of 209 studies that performed with cellular models, 208 proteins influenced by cadmium exposure were identified. All of these were assessed by Western blotting and were recognized as key nodes in network analyses...
November 1, 2016: Toxicology and Applied Pharmacology
Conrad E Vissink, Susanne M Huijts, G Ardine de Wit, Marc J M Bonten, Marie-Josée J Mangen
BACKGROUND: Community-acquired pneumonia (CAP) is one of the most common infections, especially in the elderly (≥65 years). The aim of this study was to quantify hospitalization costs for CAP in different age groups and in patients with different CAP risk profiles. Secondary objectives were to assess disease severity differences between placebo and vaccine receiving participants and identify cost driving factors of CAP in hospitalized elderly in the Netherlands. METHODS: This prospective cohort study of hospitalized CAP patients was executed in parallel to the Community Acquired Pneumonia Immunization Trial in Adults (CAPiTA)...
September 2, 2016: BMC Infectious Diseases
Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Hideo Kawabata, Ikuno Nishibuchi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata
PURPOSE: The purpose of this study was to prospectively investigate clinical correlations between dosimetric parameters associated with radiation pneumonitis (RP) and functional lung imaging. METHODS AND MATERIALS: Functional lung imaging was performed using four-dimensional computed tomography (4D-CT) for ventilation imaging, single-photon emission computed tomography (SPECT) for perfusion imaging, or both (V/Q-matched region). Using 4D-CT, ventilation imaging was derived from a low attenuation area according to CT numbers below different thresholds (vent-860 and -910)...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
Bilge Karatoy Erdem, Fatih Davran, Vural Taner Yilmaz, Ramazan Çetinkaya, Halide Akbas
BACKGROUND: The kidney is often affected in plasma cell dyscrasias, usually due to the effects of nephrotoxic monoclonal-free light chains. Renal failure due to a monoclonal gammopathy may be detected by the highly sensitive serum-free light-chain (sFLC) ratio yet missed by electrophoretic assays. The aim of this study was to assess sFLC levels in relation to markers of renal function. METHODS: Five-hundred thirteen patients were included in this study. sFLC levels were measured by Freelite® (The Binding Site Group Ltd, Birmingham, UK) assay using the BNII nephelometer (Siemens Diagnostics, Germany)...
July 2015: Renal Failure
David Al Dulaimi
Dong Y, Qi B, Feng XY, Jiang CM. Meta-analysis of Barrett's esophagus in China. World J Gastroenterol 2013;19(46):8770-8779 The disease pattern of Barrett's esophagus (BE) in China is poorly characterised particularly in comparison with other developed countries. This meta-analysis of 3873 cases of BE collated from 69 clinical studies conducted in 25 provinces between 2000 and 2011 investigated the epidemiology and characteristics of BE in China compared to Western countries. The total endoscopic detection rate of BE was 1...
2014: Gastroenterology and Hepatology From Bed to Bench
Elizabeth P Schlaudecker, Joan P Heck, Elizabeth T MacIntyre, Ruben Martinez, Caitlin N Dodd, Monica M McNeal, Mary A Staat, Jeffery E Heck, Mark C Steinhoff
Limited data are available in rural Honduran settings describing the etiology of respiratory infections, partially due to limited specimen transport. A new molecular transport media (MTM) preserves released nucleic acid at ambient temperature for later detection. Prospective surveillance was conducted in a Honduran clinic to identify 233 children less than 5 years of age presenting with respiratory symptoms. We obtained 2 nasopharyngeal samples and stored 1 in PrimeStore® MTM at room temperature and 1 in universal transport media (UTM) at -80 °C...
October 2014: Diagnostic Microbiology and Infectious Disease
Shiu-Dong Chung, Jau-Der Ho, Chao-Chien Hu, Herng-Ching Lin, Jau-Jiuan Sheu
PURPOSE: To investigate the risk for Parkinson disease during a 3-year follow-up period after a diagnosis of neovascular age-related macular degeneration (AMD) using a nationwide population-based dataset in Taiwan. DESIGN: A retrospective matched-cohort study. METHODS: We identified 877subjects with neovascular AMD as the study cohort and randomly selected 8770 subjects for a comparison cohort. Each subject was individually followed for a 3-year period to identify those who subsequently developed Parkinson disease...
February 2014: American Journal of Ophthalmology
Barbara Yawn, Karen Duvall, John Peabody, Frank Albers, Ahmar Iqbal, Stephen Koval, Heather Paden, William Wadland
SESSION TYPE: COPD: Diagnosis and EvaluationPRESENTED ON: Sunday, October 21, 2012 at 01:15 PM - 02:45 PMPURPOSE: COPD is often not diagnosed or diagnosed in later stages. Earlier diagnosis and intervention can lead to improved quality of life and physical functioning, fewer exacerbations, and lower mortality. The Screening, Evaluating and Assessing Rate CHanges of Diagnosing Respiratory Conditions in Primary Care (SEARCH) prospective cluster-randomized study assessed a symptom-based COPD population screener [COPD-PS] questionnaire with/without FEV1/FEV6 assessment by use of a handheld spirometric device [copd-6] to identify undiagnosed patients with COPD...
October 1, 2012: Chest
Melissa M Brown, Gary C Brown, Heidi B Lieske, P Alexander Lieske
PURPOSE OF REVIEW: This analysis discusses the comparative effectiveness and cost-effectiveness of vitreoretinal interventions, measured in quality-adjusted life years (QALYs) and percentage patient value (PPV gain, or improvement in quality of life and/or length of life). The material is relevant since the Patient Protection and Affordable Care Act enacted by Congress with the support of the President has emphasized the critical importance of patient-based preferences. RECENT FINDINGS: The majority of preference-based, comparative effectiveness and cost-effectiveness vitreoretinal interventions assessed in the US healthcare literature are Value-Based Medicine analyses, thus comparable...
May 2012: Current Opinion in Ophthalmology
Samjin Choi, Su-Jin Chae, Sung Wook Kang, Youjin Cheong, Seung-Jae Hong, Hun-Kuk Park
OBJECTIVE: This study presents a method for non-invasive screening of progressive arthritic reactions in a representative rheumatoid arthritis (RA) animal model of Type II collagen-induced arthritis (CIA). MATERIALS: Seventeen male DBA/1J mice (9 weeks old) were used for the control group (seven) and the CIA group (ten). TREATMENT: The CIA model was induced by the injection of a Type II collagen and incomplete Freund's adjuvant emulsion. METHODS: Arthritic reactions including joint space narrowing (JSN), bone erosion, inflammation, and physiological defects were observed using five non-invasive methods...
May 2011: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
José A Olivas-Ávila, Bertha Musi-Lechuga
The present work is a descriptive study by means of document analysis that aims to make the analysis of the more productive professors of psychology in Spain trough indexed Web of Science journal articles. The sample was conformed of the first one hundred more productive professors of each one of the six academic areas of Spanish Psychology. A total of 85492 records were analyzed of which 8770 correspond to the 610 analyzed professors. The main results are that from the more productive professors ranking, six belong to the Psychobiology area and only 4 belong to different areas...
November 2010: Psicothema
Cecile Tissot, Holger Buchholz, Max B Mitchell, Eduardo da Cruz, Shelley D Miyamoto, Bill A Pietra, Arnaud Charpentier, Olivier Ghez
INTRODUCTION: Mechanical circulatory devices are indicated in patients with refractory cardiac failure as a bridge to recovery or to transplantation. Whenever required, transportation while on mechanical support is a challenge and still limited by technical restrictions or distance. CASE REPORT: We report the first pediatric case of transatlantic air transportation on a Berlin Heart EXCOR ventricular assist device (Berlin Heart, Berlin, Germany) of a 13-yr-old American female who presented in cardiogenic shock with severe systolic dysfunction while vacationing in France...
March 2010: Pediatric Critical Care Medicine
Wu Ji, Kai Ding, Ling-Tang Li, Dan Wang, Ning Li, Jie-Shou Li
BACKGROUND: Outpatient laparoscopic cholecystectomy (OPLC) developed in the United States and other developed countries as one of the fast-track surgeries performed in ambulatory centers. However, this practice has not been installed as a routine practice in the major general hospitals and medical centers in China. We designed this case-control study to evaluate the feasibility, benefits, and safety of OPLC. METHODS: Two hundred patients who had received laparoscopic cholecystectomy for various benign gallbladder pathologies from April 2007 to December 2008 at Jinling Hospital of Nanjing University School of Medicine were classified into two groups: OPLC group (100 patients), and control group (100), who were designated for inpatient laparoscopic cholecystectomy (IPLC)...
February 2010: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Louise Dye, Michael Mansfield, Nicola Lasikiewicz, Lena Mahawish, Rainer Schnell, Duncan Talbot, Hitesh Chauhan, Fiona Croden, Clare Lawton
The aim of the present study was to validate the Glucoday continuous interstitial ambulatory glucose-monitoring device (AGD) against plasma glucose measured from arterialised venous (AV) and glucose from capillary whole blood (finger prick, FP) in non-diabetic subjects in response to an oral glucose tolerance test. Fifteen healthy overweight men (age 30-49 years, BMI 26-31 kg/m2) participated. Glucose levels were measured before, during and after consumption of an oral 75 g glucose load using twelve FP samples and forty-four 1 ml AV blood samples during 180 min...
January 2010: British Journal of Nutrition
Shiladitya Mukherjee, John Abraham
In this work, axisymmetric computations of drop impingement on dry walls are presented. The two-phase model employed is an axisymmetric lattice-Boltzmann model. Computations are performed in the parametric range of Weber number We of 7 to 8770, Ohnesorge number Oh of 0.02 to 0.137, and drop-wall equilibrium contact angle theta(eq) of 35 degrees to 150 degrees . Deposition and rebound outcomes are reported. In deposition, the different stages of drop evolution including spread, recoil and equilibration are reproduced and studied...
August 15, 2007: Journal of Colloid and Interface Science
Jeffrey E Lee, Winnie Luong, David J T Huang, Kenneth A Cornell, Michael K Riscoe, P Lynne Howell
5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) is important in a number of cellular functions such as polyamine biosynthesis, methionine salvaging, biological methylation, and quorum sensing. The nucleosidase is found in many microbes but not in mammalian systems, thus making MTAN a broad-spectrum antimicrobial drug target. Substrate binding and catalytic residues were identified from the crystal structure of MTAN complexed with 5'-methylthiotubercidin [Lee, J. E., Cornell, K. A., Riscoe, M...
August 23, 2005: Biochemistry
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