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Atopic march

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https://www.readbyqxmd.com/read/29153857/predicting-the-atopic-march-results-from-the-canadian-healthy-infant-longitudinal-development-study
#1
Maxwell M Tran, Diana L Lefebvre, Christoffer Dharma, David Dai, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years. METHODS: Children completed skin prick testing at age 1 year. Children were considered sensitized if they produced a wheal 2 mm or larger than that elicited by the negative control to any of 10 inhalant or food allergens...
November 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29117309/effect-of-oral-administration-of-a-mixture-of-probiotic-strains-on-scorad-index-and-use-of-topical-steroids-in-young-patients-with-moderate-atopic-dermatitis-a-randomized-clinical-trial
#2
Vicente Navarro-López, Ana Ramírez-Boscá, Daniel Ramón-Vidal, Beatriz Ruzafa-Costas, Salvador Genovés-Martínez, Empar Chenoll-Cuadros, Miguel Carrión-Gutiérrez, José Horga de la Parte, David Prieto-Merino, Francisco M Codoñer-Cortés
Importance: Oral intake of new probiotic formulations may improve the course of atopic dermatitis (AD) in a young population. Objective: To determine whether a mixture of oral probiotics is safe and effective in the treatment of AD symptoms and to evaluate its influence on the use of topical steroids in a young population. Design, Setting, and Participants: A 12-week randomized, double-blind, placebo-controlled intervention trial, from March to June 2016, at the outpatient hospital Centro Dermatológico Estético de Alicante, Alicante, Spain...
November 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29073215/toxoplasma-gondii-serine-protease-inhibitor-1-a-new-adjuvant-candidate-for-asthma-therapy
#3
Ariadna S Soto, Ignacio M Fenoy, Vanesa R Sanchez, Florencia March, Matías D Perrone Sibilia, María de Los Angeles Aldirico, Mariano S Picchio, Nadia Arcon, Patricio L Acosta, Fernando P Polack, Valentina Martin, Alejandra Goldman
Serine-proteases are important players in the pathogenesis of asthma, promoting inflammation and tissue remodeling. It's also known that many serine protease inhibitors display immunomodulatory properties. TgPI-1 is a Toxoplasma gondii protein that exhibits broad spectrum inhibitory activity against serine proteases. In view of the increased prevalence of atopic disorders and the need to develop new treatment strategies we sought to investigate the potential of TgPI-1 for treating respiratory allergies. For this purpose, we developed a therapeutic experimental model...
2017: PloS One
https://www.readbyqxmd.com/read/29063427/atopic-dermatitis-disease-background-and-risk-factors
#4
Zelma C Chiesa Fuxench
Multiple risk factors have been associated with the development of atopic dermatitis (AD). Recent advances in understanding the role of genetics in this disease have been made, with discovery of the filaggrin (FLG) gene as the most notable so far. In addition to FLG gene mutations as a risk factor for AD, a positive family history of atopic or allergic disease in either parent, has been shown to confer a greater risk of developing AD. Atopic dermatitis usually presents early in life and is thought to represent the initial-step in the "atopic march" which is characterized by the development of other atopic diseases later in life such as asthma, allergic rhinitis and/or rhinoconjunctivitis, food allergies and hay fever...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#5
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28937540/herpes-simplex-virus-esophagitis-in-immunocompetent-children-a-harbinger-of-eosinophilic-esophagitis
#6
Julia Fritz, Diana Lerner, Mariko Suchi
Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed sixteen cases of HSV esophagitis diagnosed from January, 1982 to March, 2016. Five patients were immunosuppressed, 11 were immunocompetent and included in the study. Three (27%) had no other significant medical history. Five patients (45%) had repeat biopsies following their HSV infection which showed eosinophilic infiltrate consistent with current diagnostic criteria of eosinophilic esophagitis (EoE), one of whom had known EoE...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28912020/intestinal-dysbiosis-featuring-abundance-of-ruminococcus-gnavus-associates-with-allergic-diseases-in-infants
#7
Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, Yen-Hsuan Ni
BACKGROUND & AIMS: Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS: We studied fecal specimens prospectively in a twin cohort (n=30) and age-matched singletons (n=14) born at National Taiwan University Children's Hospital, Taipei, Taiwan, from April 2011 to March 2013...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28889151/hydrogen-water-ameliorates-the-severity-of-atopic-dermatitis-like-lesions-and-decreases-interleukin-1%C3%AE-interleukin-33-and-mast-cell-infiltration-in-nc-nga-mice
#8
Takuya Kajisa, Takuji Yamaguchi, Ailing Hu, Nobuhiro Suetake, Hiroyuki Kobayashi
OBJECTIVES: To examine the effect of hydrogen water (HW) on the severity of atopic dermatitis (AD) and elucidate the underlying pathophysiological mechanisms. METHODS: For this experimental study between March 2015 and December 2015, NC/Nga mice characterized by mild AD severity were given either HW (n=11) or purified water (PW) (n=9) ad libitum; specific-pathogen-free mice (n=9) were used as AD-free control. Atopic dermatitis severity score and transepidermal water loss (TEWL) were examined at baseline (0 week), and after 4 weeks of HW/PW treatment...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28818439/variations-in-risk-of-asthma-and-seasonal-allergies-between-early-and-late-onset-pediatric-atopic-dermatitis-a-cohort-study
#9
Joy Wan, Nandita Mitra, Ole J Hoffstad, Joel M Gelfand, Albert C Yan, David J Margolis
BACKGROUND: Atopic dermatitis is associated with other allergic conditions, but variations in this "atopic march" are poorly understood. OBJECTIVE: To determine the impact of the age of atopic dermatitis onset on the risk for asthma and seasonal allergies. METHODS: A cohort study was performed using the Pediatric Eczema Elective Registry, which is an observational cohort of subjects with pediatric onset atopic dermatitis. RESULTS: In total, 3966 children were included, and 73% reported atopic dermatitis onset before age 2 years...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28800272/omalizumab-in-non-allergic-asthma-a-report-of-13-cases
#10
Zeynep Çelebi Sözener, Ömür Aydın, Zeynep Mısırlıgil, Dilşad Mungan, Yavuz Selim Demirel, Gülfem E Çelik, Betül A Sin, Sevim Bavbek
BACKGROUND: There are limited data regarding the effectiveness of omalizumab in patients with non-allergic asthma. OBJECTIVE: To evaluate the clinical and functional effectiveness of omalizumab in patients with non-allergic asthma. METHODS: The study was a single-center, retrospective chart review of patients with non-allergic asthma who were treated with add-on omalizumab between February 2014 and March 2016. After omalizumab was started, data of the asthma control test (ACT), pulmonary function test, and daily oral corticosteroid (OCS) dosage were collected at baseline, 16 weeks, 1 year, 2 and 3 years (if available)...
August 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28708993/il-4r%C3%AE-inhibitor-for-atopic-disease
#11
Howard Y Chang, Kari C Nadeau
Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive type 2 inflammatory response. In March 2017, dupilumab was approved for use in the treatment of atopic dermatitis (eczema). To view this Bench to Bedside, open or download the PDF.
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28698345/suboptimal-vitamin-d-status-in-korean-adolescents-a-nationwide-study-on-its-prevalence-risk-factors-including-cotinine-verified-smoking-status-and-association-with-atopic-dermatitis-and-asthma
#12
Eun Jung Byun, Jinyoung Heo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
OBJECTIVE: To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level. DESIGN: This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Blood and urine samples were taken for vitamin D and cotinine, respectively...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28668109/seasonal-variation-and-monthly-patterns-of-skin-symptoms-in-korean-children-with-atopic-eczema-dermatitis-syndrome
#13
Minji Kim, Young-Min Kim, Ji Young Lee, Hea-Kyoung Yang, Hyunmi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: There have been controversies about the seasonality in aggravation of atopic eczema/dermatitis syndrome (AEDS) symptoms, although understanding the seasonal patterns of AEDS symptoms is an important step in preventing exacerbation through proactive management. OBJECTIVE: The aim of this study was to evaluate whether there are seasonal variations or monthly patterns of symptoms in children with AEDS. METHODS: A total of 590 children with AEDS (median age, 21 months) were enrolled and were followed up for at least 1 year between August 2012 and March 2015...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28658558/the-atopic-march-current-insights-into-skin-barrier-dysfunction-and-epithelial-cell-derived-cytokines
#14
REVIEW
Hongwei Han, Florence Roan, Steven F Ziegler
Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28656964/il-33-promotes-gastrointestianl-allergy-in-a-tslp-independent-manner
#15
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal (GI) allergy...
June 28, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28648657/reproduction-of-the-atopic-march-in-an-adult-after-allogeneic-bone-marrow-transplantation-from-an-atopic-sibling
#16
Milagros Lázaro, Lourdes Vázquez, Francisco Javier Munoz-Bellido, Maria Teresa Gracia, Sonia Arriba-Mendez, Ignacio Dávila
No abstract text is available yet for this article.
August 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28642859/exercise-induced-bronchospasm-and-allergy
#17
REVIEW
Serena Caggiano, Renato Cutrera, Antonio Di Marco, Attilio Turchetta
Sport is an essential part of childhood, with precious and acknowledged positive health effects but the impact of exercise-induced bronchoconstriction (EIB) significantly reduces participation in physical activity. It is important to recognize EIB, differentiating EIB with or without asthma if the transient narrowing of the airways after exercise is associated with asthmatic symptoms or not, in the way to select the most appropriate treatment among the many treatment options available today. Therapy is prescribed based on symptoms severity but diagnosis of EIB is established by changes in lung function provoked by exercise evaluating by direct and indirect tests...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28620798/-inflammatory-skin-march-in-atopic-dermatitis-and-psoriasis
#18
REVIEW
Masutaka Furue, Takafumi Kadono
BACKGROUND: Comorbidities of cardiovascular diseases (CVDs), metabolic syndrome and autoimmune diseases with systemic inflammation are recent topics in medicine. Inflammatory skin diseases such as atopic dermatitis and psoriasis are an active source of diverse proinflammatory cytokines and chemokines, which are readily detectable in the circulation and are likely to be involved in developing comorbidities. EVIDENCE: Both atopic dermatitis and psoriasis are frequently comorbid with CVD, metabolic syndrome and autoimmune diseases, the consequence of which is called "inflammatory skin march", "psoriatic march" or "march of psoriasis"...
June 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28618023/is-the-atopic-march-related-to-confounding-by-genetics-and-early-life-environment-a-systematic-review-of-sibship-and-twin-data
#19
REVIEW
S J Khan, S C Dharmage, M C Matheson, L C Gurrin
A popular hypothesis known as the atopic march proposes a set of sequential allergy and respiratory disorders in early childhood contributes enormously to the burden of disease in developed countries. Although the concept of the atopic march has been refined and strengthened by many cross-sectional and longitudinal studies linking eczema as the initial manifestation with progression to hay fever and then asthma, there is yet no definitive proof that the atopic march is the primary causal factor in childhood allergic disease...
June 15, 2017: Allergy
https://www.readbyqxmd.com/read/28589008/disease-prevalence-among-nursery-school-children-after-the-great-east-japan-earthquake
#20
Mami Ishikuro, Hiroko Matsubara, Masahiro Kikuya, Taku Obara, Yuki Sato, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama
OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience...
March 2017: BMJ Global Health
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