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Atopic march

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https://www.readbyqxmd.com/read/28708993/il-4r%C3%AE-inhibitor-for-atopic-disease
#1
Howard Y Chang, Kari C Nadeau
Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive type 2 inflammatory response. In March 2017, dupilumab was approved for use in the treatment of atopic dermatitis (eczema). To view this Bench to Bedside, open or download the PDF.
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28698345/suboptimal-vitamin-d-status-in-korean-adolescents-a-nationwide-study-on-its-prevalence-risk-factors-including-cotinine-verified-smoking-status-and-association-with-atopic-dermatitis-and-asthma
#2
Eun Jung Byun, Jinyoung Heo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
OBJECTIVE: To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level. DESIGN: This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Blood and urine samples were taken for vitamin D and cotinine, respectively...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28668109/seasonal-variation-and-monthly-patterns-of-skin-symptoms-in-korean-children-with-atopic-eczema-dermatitis-syndrome
#3
Minji Kim, Young-Min Kim, Ji Young Lee, Hea-Kyoung Yang, Hyunmi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: There have been controversies about the seasonality in aggravation of atopic eczema/dermatitis syndrome (AEDS) symptoms, although understanding the seasonal patterns of AEDS symptoms is an important step in preventing exacerbation through proactive management. OBJECTIVE: The aim of this study was to evaluate whether there are seasonal variations or monthly patterns of symptoms in children with AEDS. METHODS: A total of 590 children with AEDS (median age, 21 months) were enrolled and were followed up for at least 1 year between August 2012 and March 2015...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28658558/the-atopic-march-current-insights-into-skin-barrier-dysfunction-and-epithelial-cell-derived-cytokines
#4
REVIEW
Hongwei Han, Florence Roan, Steven F Ziegler
Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28656964/il-33-promotes-gastrointestianl-allergy-in-a-tslp-independent-manner
#5
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal (GI) allergy...
June 28, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28648657/reproduction-of-the-atopic-march-in-an-adult-after-allogeneic-bone-marrow-transplantation-from-an-atopic-sibling
#6
Milagros Lázaro, Lourdes Vázquez, Francisco Javier Munoz-Bellido, Maria Teresa Gracia, Sonia Arriba-Mendez, Ignacio Dávila
No abstract text is available yet for this article.
June 22, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28642859/exercise-induced-bronchospasm-and-allergy
#7
REVIEW
Serena Caggiano, Renato Cutrera, Antonio Di Marco, Attilio Turchetta
Sport is an essential part of childhood, with precious and acknowledged positive health effects but the impact of exercise-induced bronchoconstriction (EIB) significantly reduces participation in physical activity. It is important to recognize EIB, differentiating EIB with or without asthma if the transient narrowing of the airways after exercise is associated with asthmatic symptoms or not, in the way to select the most appropriate treatment among the many treatment options available today. Therapy is prescribed based on symptoms severity but diagnosis of EIB is established by changes in lung function provoked by exercise evaluating by direct and indirect tests...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28620798/-inflammatory-skin-march-in-atopic-dermatitis-and-psoriasis
#8
REVIEW
Masutaka Furue, Takafumi Kadono
BACKGROUND: Comorbidities of cardiovascular diseases (CVDs), metabolic syndrome and autoimmune diseases with systemic inflammation are recent topics in medicine. Inflammatory skin diseases such as atopic dermatitis and psoriasis are an active source of diverse proinflammatory cytokines and chemokines, which are readily detectable in the circulation and are likely to be involved in developing comorbidities. EVIDENCE: Both atopic dermatitis and psoriasis are frequently comorbid with CVD, metabolic syndrome and autoimmune diseases, the consequence of which is called "inflammatory skin march", "psoriatic march" or "march of psoriasis"...
June 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28618023/is-the-atopic-march-related-to-confounding-by-genetics-and-early-life-environment-a-systematic-review-of-sibship-and-twin-data
#9
REVIEW
S J Khan, S C Dharmage, M C Matheson, L C Gurrin
A popular hypothesis known as the atopic march proposes a set of sequential allergy and respiratory disorders in early childhood contributes enormously to the burden of disease in developed countries. Although the concept of the atopic march has been refined and strengthened by many cross-sectional and longitudinal studies linking eczema as the initial manifestation with progression to hay fever and then asthma, there is yet no definitive proof that the atopic march is the primary causal factor in childhood allergic disease...
June 15, 2017: Allergy
https://www.readbyqxmd.com/read/28589008/disease-prevalence-among-nursery-school-children-after-the-great-east-japan-earthquake
#10
Mami Ishikuro, Hiroko Matsubara, Masahiro Kikuya, Taku Obara, Yuki Sato, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama
OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience...
March 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28583445/novel-concepts-of-prevention-and-treatment-of-atopic-dermatitis-through-barrier-and-immune-manipulations-with-implications-for-the-atopic-march
#11
REVIEW
Tali Czarnowicki, James G Krueger, Emma Guttman-Yassky
Skin barrier abnormalities have been suggested to play an essential role in initiation of early atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to increased innate immune responses, antigen-presenting cell stimulation, and priming of overt cutaneous disease. In a TH2-promoting environment, T-cell/B-cell interactions occurring in regional lymph nodes lead to excessive IgE switch. Concurrent redistribution of memory T cells into the circulation not only leads to exacerbation of AD through T-cell skin infiltration but also spreads beyond the skin to initiate the atopic march, which includes food allergy, asthma, and allergic rhinitis...
June 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28572736/asthma-like-airway-inflammation-and-responses-in-a-rat-model-of-atopic-dermatitis-induced-by-neonatal-capsaicin-treatment
#12
Rafael Taeho Han, Sewon Kim, Kyungmin Choi, Hyeonseok Jwa, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Hang-Rae Kim, Seung Keun Back, Heung Sik Na
Recent studies have shown that approximately 70% of patients with severe atopic dermatitis (AD) develop asthma. Development of AD in infancy and subsequent other atopic diseases such as asthma in childhood is referred to as atopic march. However, a causal link between the diseases of atopic march has remained largely unaddressed, possibly due to lack of a proper animal model. Recently, we developed an AD rat model showing chronically relapsing dermatitis and scratching behaviors induced by neonatal capsaicin treatment...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28555328/evolving-concepts-in-atopic-dermatitis
#13
REVIEW
Robert Sidbury, Kate Khorsand
PURPOSE OF REVIEW: Tremendous advances have been made in the field of atopic dermatitis in the past 5 years. We will explore developments in burden of disease, co-morbidities, pathogenesis, prevention, and management. RECENT FINDINGS: The tremendous burden moderate to severe atopic dermatitis (AD) places on families from a medical, psychosocial, and financial perspective has been characterized. Epidemiologic studies have identified intriguing new associations beyond the well-characterized "atopic march" of food allergies, asthma, and hay fever...
July 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28547386/dupilumab-first-global-approval
#14
REVIEW
Matt Shirley
Dupilumab (Dupixent(®)) is a fully human monoclonal antibody directed against the interleukin (IL)-4 receptor α (IL-4Rα) subunit. Dupilumab inhibits the signalling of the type 2 cytokines IL-4 and IL-13 and was co-developed by Regeneron Pharmaceuticals and Sanofi as a potential therapeutic agent for the treatment of atopic or allergic diseases. In March 2017 dupilumab received its first global approval, in the USA, for use in the treatment of adult patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable...
July 2017: Drugs
https://www.readbyqxmd.com/read/28538875/particular-characteristics-of-atopic-eczema-in-tropical-environments-the-tropical-environment-control-for-chronic-eczema-and-molecular-assessment-teccema-cohort-study
#15
Jorge Sánchez, Andrés Sánchez, Ricardo Cardona
Background: Atopic dermatitis is a prevalent health problem in the world. Allergic sensitization is an important risk factor, but the roles of other factors, inherent in tropic region, are unknown. Objective: A cohort study was designed in a tropical city to investigate molecular and environmental risk factors for eczema, considering as particular features perennial exposure to mites, poor living conditions and others tropical characteristics. Methods: 433 patients were included at baseline and biological samples were collected during 24 months of follow-up...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#16
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
July 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28490737/intradermal-administration-of-il-33-induces-allergic-airway-inflammation
#17
Hongwei Han, Steven F Ziegler
Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the "atopic march". While the underlying cause of the atopic march remains unknown, recent evidence suggests that epithelial cell (EC)-derived cytokines play a major role. We showed that mice exposed to antigen through the skin, in the presence of IL-33, developed antigen-specific airway inflammation when later challenged in the lung...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401436/cypress-pollinosis-from-tree-to-clinic
#18
REVIEW
Denis Charpin, Christian Pichot, Jordina Belmonte, Jean-Pierre Sutra, Jarmila Zidkova, Pascal Chanez, Youcef Shahali, Hélène Sénéchal, Pascal Poncet
Cypress (Cupressus sp.pl) is a genus within the Cupressaceae family. This family covers all of the Earth's continents except for Antarctica, and it includes about 160 species. The most important taxa for allergic diseases belong to five different genera: Cupressus, Hesperocyparis, Juniperus, Cryptomeria, and Chamaecyparis. Cupressaceae species share a common pollen type that can even include the genus Taxus (Taxaceae) when this plant is also present. As Juniperus oxycedrus pollinates in October, Cupressus sempervirens in January and February, Hesperocyparis arizonica (prev...
April 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28339128/life-course-of-atopy-and-allergy-related-disease-events-in-tropical-sub-saharan-africa-a-birth-cohort-study
#19
Swaib A Lule, Harriet Mpairwe, Margaret Nampijja, Florence Akello, Joyce Kabagenyi, Benigna Namara, Gyaviira Nkurunungi, Dennison Kizito, Joseph Kahwa, Lawrence Muhangi, Stephen Nash, Moses Muwanga, Emily L Webb, Alison M Elliott
BACKGROUND: In high-income countries, allergy-related diseases (ARDs) follow a typical sequence, the 'Atopic March'. Little is known about the life-course of ARDs in the markedly different, low-income, tropical environment. We describe ARDs in a tropical, African birth cohort. METHODS: Ugandan children were followed from birth to 9 years. ISAAC questionnaires were completed at intervals; doctor-diagnosed ARDs were recorded throughout follow-up. Skin prick tests (SPTs) were performed at 3 and 9 years...
June 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28294587/vitamin-d-levels-and-allergic-diseases-an-italian-cross-sectional-multicenter-survey
#20
C Lombardi, G Passalacqua
Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases...
March 2017: European Annals of Allergy and Clinical Immunology
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