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Atopic march

T Banti, A Carsin, B Chabrol, R Reynaud, A Fabre
: Infant food diversification has undergone a rapid succession of good practice recommendations in France, but there has been no assessment of pediatrician practices on food diversification. OBJECTIVE: To assess the practices of pediatricians in relation to current recommendations of the French Society of Pediatrics on infant food diversification. METHODS: This was an observational study conducted from 1 November 2014 to 31 March 2015. The study population consisted of 97 pediatricians in the Var department and 84 pediatric residents assigned to the University of Aix-Marseille in France...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Sefayet Karaca, Ersoy Civelek, Mehmet Karaca, Umit M Sahiner, Riza K Ozgul, Can N Kocabas, Renato Polimanti, Bülent E Sekerel
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests...
2016: Scientific Reports
Shatha A Alduraywish, Marie Standl, Caroline J Lodge, Michael J Abramson, Katrina J Allen, Bircan Erbas, Andrea von Berg, Joachim Heinrich, Adrian J Lowe, Shyamali C Dharmage
BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094)...
September 3, 2016: Pediatric Allergy and Immunology
Gyohei Egawa, Kenji Kabashima
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized world and has multiple causes. Over the past decade, data from both experimental models and patients have highlighted the primary pathogenic role of skin barrier deficiency in patients with AD. Increased access of environmental agents into the skin results in chronic inflammation and contributes to the systemic "atopic (allergic) march." In addition, persistent skin inflammation further attenuates skin barrier function, resulting in a positive feedback loop between the skin epithelium and the immune system that drives pathology...
August 2016: Journal of Allergy and Clinical Immunology
Jung-Min Park, Ju-Hyun Jo, Hyunju Jin, Hyun-Chang Ko, Moon-Bum Kim, Jung-Min Kim, Do-Won Kim, Ho-Sun Jang, Byung-Soo Kim
BACKGROUND: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S...
August 2016: Annals of Dermatology
Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, Jeng-Dau Tsai
Primary immune thrombocytopenia (ITP) is currently defined as an acquired autoimmune disorder with persistent thrombocytopenia. However, the temporal interaction between T helper type 2 cell (Th2)-mediated allergic diseases and T helper type 1 cell (Th1)-mediated ITP remains unknown. Atopic dermatitis (AD) is considered one of the first steps in the atopic march. Herein, we conducted a population-based cohort analysis to investigate the risk of ITP in children with AD in comparison with non-AD controls. We subsequently compared the occurrence of other autoimmune diseases in ITP children in both AD and non-AD cohorts...
July 2016: Medicine (Baltimore)
Brittany L Vieira, Neil R Lim, Mary E Lohman, Peter A Lio
BACKGROUND: Complementary and alternative interventions are becoming increasingly utilized as adjuncts to conventional treatment of atopic dermatitis (AD). While the number of studies continues to grow, the vastness of the subject coupled with the relatively poor quality and small size of the studies limit their usefulness to clinicians. PURPOSE: Our aim was to comprehensively review randomized controlled trials (RCTs) of complementary and alternative therapies for AD...
July 7, 2016: American Journal of Clinical Dermatology
Avraham Kudish, Anna Marsakova, Irmgard Jahn, Spyridon Gkalpakiotis, Peter Arenberger, Marco Harari
BACKGROUND: Atopic Dermatitis (AD) is a common, chronic and relapsing inflammatory skin disorder. Moderate to severe cases represent an extremely disabling disease, for both children and their parents. Dead Sea Climatotherapy (DSC), recognized as a natural treatment for patients with skin diseases, takes advantage of the selectively scattered ultraviolet irradiation (UV) present at the lowest terrestrial site on the earth. OBJECTIVES: To investigate the impact on short-term results of DSC in moderate to severe AD children from the Czech Republic treated 4 weeks at the Deutsches Medizinisches Zentrum (DMZ), Israel and to correlate their results to the cumulative UVA and UVB irradiation doses received during treatment...
July 5, 2016: Photodermatology, Photoimmunology & Photomedicine
Hae-Jin Lee, Noo Ri Lee, Bo-Kyung Kim, Minyoung Jung, Dong Hye Kim, Catharina S Moniaga, Kenji Kabashima, Eung Ho Choi
The presence of congenitally impaired skin barrier followed by atopic dermatitis (AD) is an initial step in the atopic march. The maintenance of acidic pH in the stratum corneum (SC) has been suggested as a therapeutic or preventive strategy for barrier impairment caused by skin inflammation. To determine whether an AD murine model, flaky tail mice, with inherited filaggrin deficiency could develop airway inflammation by repeated topical application followed by nasal inhalation of house dust mite (HDM) antigen (defined as a novel 'atopic march animal model'), and whether maintenance of an acidic SC environment by continuous application of acidic cream could interrupt the following atopic march...
July 4, 2016: Experimental Dermatology
Jayanta Gupta, Elisabet Johansson, Jonathan A Bernstein, Ranajit Chakraborty, Gurjit K Khurana Hershey, Marc E Rothenberg, Tesfaye B Mersha
Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic disorders of complex etiology. The frequently observed atopic march from early AD to asthma, allergic rhinitis, or both later in life and the extensive comorbidity of atopic disorders suggest common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African Americans when compared with European Americans...
September 2016: Journal of Allergy and Clinical Immunology
Nanette B Silverberg
In part 2 of this 3-part series on atopic dermatitis (AD) in children, triggers for the appearance and flaring of AD are reviewed. The role of AD in the atopic march is explored. Furthermore, the usage of grading systems in the development of therapeutics and in clinical care is discussed. The natural history of AD has changed from improvement to 50% persistence and therefore it is important to council guardians and patients accordingly.
May 2016: Cutis; Cutaneous Medicine for the Practitioner
Lynda Schneider, Jon Hanifin, Mark Boguniewicz, Lawrence F Eichenfield, Jonathan M Spergel, Rada Dakovic, Amy S Paller
BACKGROUND: Atopic dermatitis (AD) is often the first step in the atopic march leading to the development of asthma or allergic rhinitis. The goal of this study was to determine whether early intervention with pimecrolimus limits the atopic march in infants with AD and to evaluate its efficacy and safety. METHODS: This was a 3-year double-blind study in which patients were randomized to pimecrolimus or vehicle and then open-label pimecrolimus for a planned further 3 years...
July 2016: Pediatric Dermatology
N Lomidze, T Abramidze, T Gotua, N Dolidze, M Gotua
The aim of our study was to investigate sensitization pattern to food allergens in different age groups of atopic patients in Georgia and reveal the associations between food sensitization and clinical manifestations of allergic disease reflecting the development of atopic march. 1000 patients (children-783, adult-217) with different clinical manifestations were involved in the study. Specific IgE antibodies to food mix, cow's milk, casein, egg, wheat, fish, nuts mixture and inhalant allergens were measured by using ImmunoCap (Phadia, Uppsala, Sweden)...
April 2016: Georgian Medical News
Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Yeongho Kim, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon, Soo-Jong Hong
BACKGROUND: Allergic rhinitis (AR) has a wide range of clinical features and may be accompanied by comorbid allergic diseases. OBJECTIVE: To identify rhinitis phenotypes in school aged children and to predict the prognosis for developing bronchial hyperresponsiveness (BHR) and asthma. METHODS: This prospective follow-up study involved schoolchildren from the Children's Health and Environment Research cohort with current rhinitis, which was defined based on parental-reported, physician-diagnosed rhinitis and symptoms of rhinitis in the previous 12 months...
July 2016: Annals of Allergy, Asthma & Immunology
S Kılıç, F Sılan, M M Hız, S Işık, Z Ögretmen, Ö Özdemir
BACKGROUND AND OBJECTIVE: The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. PATIENTS AND METHODS: This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in Çanakkale, Turkey. Peripheral blood samples were collected in EDTA tubes...
2016: Journal of Investigational Allergology & Clinical Immunology
Sakiko Shimura, Toshiro Takai, Hideo Iida, Natsuko Maruyama, Hirono Ochi, Seiji Kamijo, Izumi Nishioka, Mutsuko Hara, Akira Matsuda, Hirohisa Saito, Susumu Nakae, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda
Allergen sources such as mites, insects, fungi, and pollen contain proteases. Airway exposure to proteases induces allergic airway inflammation and IgE/IgG1 responses via IL-33-dependent mechanisms in mice. We examined the epicutaneous sensitization of mice to a model protease allergen, papain; the effects of tape stripping, which induces epidermal barrier dysfunction; and the atopic march upon a subsequent airway challenge. Papain painting on ear skin and tape stripping cooperatively promoted dermatitis, the skin gene expression of proinflammatory cytokines and growth factors, up-regulation of serum total IgE, and papain-specific IgE/IgG1 induction...
July 2016: Journal of Investigative Dermatology
J N Técléssou, A Mouhari-Toure, S Akakpo, S Bayaki, O B T Boukari, Y M Elégbédé, W Gnassingbé, K Kombaté, H Yédomon, P Pitché
OBJECTIVE: The aim of this study was to determine the prevalence and document the risk factors and allergic reactions associated with atopic dermatitis (AD) in children in Lomé. METHOD: This cross-sectional multicenter study took place from March to June 2013 in four health facilities in Lomé. It applied the criteria of the United Kingdom Working Party (UKWP). RESULTS: We included 476 children aged 0-15 years who came for a vaccination or pediatric consultation; 31...
January 2016: Médecine et Santé Tropicales
T K Lajunen, J J K Jaakkola, M S Jaakkola
Interleukin 6 (IL6) is an inflammatory cytokine that has been suggested to have an important role in the pathogenesis of asthma. IL6 single-nucleotide polymorphisms (SNPs) have been associated with levels of IL6, and with childhood and prevalent adult asthma. A recent study also suggested that IL6 SNPs associate especially with atopic asthma. However, association of IL6 SNPs with adult-onset asthma has not been studied. In a population-based study of 467 incident adult-onset asthma cases and 613 disease-free controls from South Finland, we analyzed association of 6 tagging SNPs of the IL6 locus with the risk of adult-onset asthma and with atopy...
April 2016: Genes and Immunity
Maeve M Kelleher, Audrey Dunn-Galvin, Claire Gray, Deirdre M Murray, Mairead Kiely, Louise Kenny, W H Irwin McLean, Alan D Irvine, Jonathan O'B Hourihane
BACKGROUND: Transcutaneous exposure to food allergens can lead to food sensitization (FS)/food allergy (FA). We measured skin barrier function in early infancy and related it to the later development of FS/FA at age 2 years. OBJECTIVE: We sought to examine the relationship between early life skin barrier function and FA in infancy. METHODS: Infants in the Babies After Scope: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) birth cohort had transepidermal water loss (TEWL) measured in the early newborn period and at 2 and 6 months of age...
April 2016: Journal of Allergy and Clinical Immunology
Cherie M Pucheu-Haston
Dogs may develop a syndrome of spontaneous, inflammatory, pruritic dermatitis that shares many features with human atopic dermatitis, including a young age of onset, characteristic lesion distribution, immunoglobulin E sensitization to common environmental allergen sources, and evidence of epidermal barrier dysfunction. There are also several important differences between canine and human atopic dermatitis. Although dogs may suffer from multiple-organ hypersensitivity syndromes, there is no evidence that this species experiences the progressive evolution from cutaneous to respiratory allergy characteristic of the human atopic march...
March 2016: Clinics in Dermatology
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