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Atopic march

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https://www.readbyqxmd.com/read/27900997/clinical-application-of-the-uk-working-party-s-criteria-for-the-diagnosis-of-atopic-dermatitis-in-the-chinese-population-by-age-group
#1
Li Wang, Lin-Feng Li
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease with an increasingly significant prevalence. The prevalence of AD depends greatly on how its diagnosis is done. The UK Working Party's diagnostic criteria for AD are simple and easy to apply without invasive laboratory tests. This study assessed the clinical utility of these criteria in China. METHODS: Data were collected from 6208 patients at 31 tertiary hospitals in 13 Chinese provinces/municipalities from March 2014 to May 2014...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27869727/respiratory-diseases-in-university-students-associated-with-exposure-to-residential-dampness-or-mold
#2
Mathieu Lanthier-Veilleux, Geneviève Baron, Mélissa Généreux
University students are frequently exposed to residential dampness or mold (i.e., visible mold, mold odor, dampness, or water leaks), a well-known contributor to asthma, allergic rhinitis, and respiratory infections. This study aims to: (a) describe the prevalence of these respiratory diseases among university students; and (b) examine the independent contribution of residential dampness or mold to these diseases. An online survey was conducted in March 2014 among the 26,676 students registered at the Université de Sherbrooke (Quebec, Canada)...
November 18, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27861727/efficacy-and-safety-of-wet-wrap-therapy-for-patients-with-atopic-dermatitis-a-systematic-review-and-meta-analysis
#3
REVIEW
G González-López, R M Ceballos-Rodríguez, J J González-López, M Feito Rodríguez, P Herranz-Pinto
BACKGROUND: Wet wrap therapy (WWT) consists of topical steroids administered under a layer of wet cotton bandages or garments. Several trials with WWT have reported promising results in atopic dermatitis (AD). However, no systematic review and meta-analysis on its efficacy and safety has been published. OBJECTIVES: To systematically review the literature on WWT in AD to assess its efficacy and safety. METHODS: We included randomized controlled trials among patients of all ages with a diagnosis of AD based on predefined criteria or performed by a dermatologist...
November 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27845281/patterns-of-sensitization-by-food-and-inhalant-components-in-georgian-patients
#4
N Lomidze, M Gotua
Molecular-based allergy (MA) diagnostics is a novel approach used to map the allergen sensitization of a patient at a molecular level, using purified natural or recombinant allergen components instead of allergen extracts. The aim of our study was to: 1) investigate sensitization patterns to food and inhalant allergen components in different age groups of Georgian allergic patients 2) evaluate patient's potential risk of systemic reaction and manage dietary modifications. 3) Study food and inhalant components in different age groups in correlation with clinical manifestations of allergic disease...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27802847/a-multistrain-probiotic-formulation-attenuates-skin-symptoms-of-atopic-dermatitis-in-a-mouse-model-through-the-generation-of-cd4-foxp3-t-cells
#5
Joo-Hyun Shin, Myung-Jun Chung, Jae-Gu Seo
BACKGROUND: Atopic dermatitis (AD) is characterized by chronic inflammation of the skin. AD develops mainly in infants and young children. It induces skin disorders and signals the initiation of the allergic march including allergic asthma and rhinitis. Probiotics modify intestinal microbial populations in a beneficial way for human and animal hosts by reducing inflammatory cytokines. OBJECTIVE: As a result of their immunomodulatory properties, probiotics have been considered a promising therapeutic option for the prevention and treatment of AD...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27790282/association-of-specific-immunoglobulin-e-to-staphylococcal-enterotoxin-with-airway-hyperresponsiveness-in-asthma-patients
#6
Seong Han Kim, Seo Yeon Yang, Jihong You, Sang Bae Lee, Jin You, Yoon Soo Chang, Hyung Jung Kim, Chul Min Ahn, Min Kwang Byun, Hye Jung Park, Jung-Won Park
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. METHODS: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27771048/increasing-comorbidities-suggest-that-atopic-dermatitis%C3%A2-is%C3%A2-a%C3%A2-systemic-disorder
#7
Patrick M Brunner, Jonathan I Silverberg, Emma Guttman-Yassky, Amy S Paller, Kenji Kabashima, Masayuki Amagai, Thomas A Luger, Mette Deleuran, Thomas Werfel, Kilian Eyerich, Georg Stingl
Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies...
October 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27642151/-infant-food-diversification-assessment-of-practices-in-relation-to-french-recommendations-in-pediatricians-and-pediatric-residents-in-southern-france
#8
T Banti, A Carsin, B Chabrol, R Reynaud, A Fabre
: Infant food diversification has undergone a rapid succession of good practice recommendations in France, but there has been no assessment of pediatrician practices on food diversification. OBJECTIVE: To assess the practices of pediatricians in relation to current recommendations of the French Society of Pediatrics on infant food diversification. METHODS: This was an observational study conducted from 1 November 2014 to 31 March 2015. The study population consisted of 97 pediatricians in the Var department and 84 pediatric residents assigned to the University of Aix-Marseille in France...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27624002/allergy-specific-phenome-wide-association-study-for-immunogenes-in-turkish-children
#9
Sefayet Karaca, Ersoy Civelek, Mehmet Karaca, Umit M Sahiner, Riza K Ozgul, Can N Kocabas, Renato Polimanti, Bülent E Sekerel
To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools. We investigated 9 loci involved in different immune functions (ADAM33, ADRB2, CD14, IL13, IL4, IL4R, MS4A2, SERPINE1, and TNF) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27590890/is-there-a-march-from-early-food-sensitization-to-later-childhood-allergic-airway-disease-results-from-two-prospective-birth-cohort-studies
#10
Shatha A Alduraywish, Marie Standl, Caroline J Lodge, Michael J Abramson, Katrina J Allen, Bircan Erbas, Andrea von Berg, Joachim Heinrich, Adrian J Lowe, Shyamali C Dharmage
BACKGROUND: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. OBJECTIVE: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10-12 years. METHODS: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094)...
September 3, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27497277/multifactorial-skin-barrier-deficiency-and-atopic-dermatitis-essential-topics-to-prevent-the-atopic-march
#11
Gyohei Egawa, Kenji Kabashima
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized world and has multiple causes. Over the past decade, data from both experimental models and patients have highlighted the primary pathogenic role of skin barrier deficiency in patients with AD. Increased access of environmental agents into the skin results in chronic inflammation and contributes to the systemic "atopic (allergic) march." In addition, persistent skin inflammation further attenuates skin barrier function, resulting in a positive feedback loop between the skin epithelium and the immune system that drives pathology...
August 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27489430/change-in-antimicrobial-susceptibility-of-skin-colonizing-staphylococcus-aureus-in-korean-patients-with-atopic-dermatitis-during-ten-year-period
#12
Jung-Min Park, Ju-Hyun Jo, Hyunju Jin, Hyun-Chang Ko, Moon-Bum Kim, Jung-Min Kim, Do-Won Kim, Ho-Sun Jang, Byung-Soo Kim
BACKGROUND: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S...
August 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27442647/atopic-dermatitis-and-association-of-risk-for-primary-immune-thrombocytopenia-and-autoimmune-diseases-among-children-a-nationwide-population-based-cohort-study
#13
Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, Jeng-Dau Tsai
Primary immune thrombocytopenia (ITP) is currently defined as an acquired autoimmune disorder with persistent thrombocytopenia. However, the temporal interaction between T helper type 2 cell (Th2)-mediated allergic diseases and T helper type 1 cell (Th1)-mediated ITP remains unknown. Atopic dermatitis (AD) is considered one of the first steps in the atopic march. Herein, we conducted a population-based cohort analysis to investigate the risk of ITP in children with AD in comparison with non-AD controls. We subsequently compared the occurrence of other autoimmune diseases in ITP children in both AD and non-AD cohorts...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27388911/complementary-and-alternative-medicine-for-atopic-dermatitis-an-evidence-based-review
#14
REVIEW
Brittany L Vieira, Neil R Lim, Mary E Lohman, Peter A Lio
BACKGROUND: Complementary and alternative interventions are becoming increasingly utilized as adjuncts to conventional treatment of atopic dermatitis (AD). While the number of studies continues to grow, the vastness of the subject coupled with the relatively poor quality and small size of the studies limit their usefulness to clinicians. PURPOSE: Our aim was to comprehensively review randomized controlled trials (RCTs) of complementary and alternative therapies for AD...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27379840/dead-sea-ultraviolet-climatotherapy-for-children-with-atopic-dermatitis
#15
Avraham Kudish, Anna Marsakova, Irmgard Jahn, Spyridon Gkalpakiotis, Peter Arenberger, Marco Harari
BACKGROUND: Atopic dermatitis (AD) is a common, chronic, and relapsing inflammatory skin disorder. Moderate to severe cases represent an extremely disabling disease, for both children and their parents. Dead Sea climatotherapy (DSC), recognized as a natural treatment for patients with skin diseases, takes advantage of the selectively scattered ultraviolet irradiation (UV) present at the lowest terrestrial site on the earth. OBJECTIVES: To investigate the impact on short-term results of DSC in moderate to severe AD children from the Czech Republic treated 4 weeks at the Deutsches Medizinisches Zentrum (DMZ), Israel, and to correlate their results to the cumulative UVA and UVB irradiation doses received during treatment...
September 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27376923/acidification-of-stratum-corneum-prevents-the-progression-from-atopic-dermatitis-to-respiratory-allergy
#16
Hae-Jin Lee, Noo Ri Lee, Bo-Kyung Kim, Minyoung Jung, Dong Hye Kim, Catharina S Moniaga, Kenji Kabashima, Eung Ho Choi
The presence of congenitally impaired skin barrier followed by atopic dermatitis (AD) is an initial step in the atopic march. The maintenance of acidic pH in the stratum corneum (SC) has been suggested as a therapeutic or preventive strategy for barrier impairment caused by skin inflammation. To determine whether an AD murine model, flaky tail mice, with inherited filaggrin deficiency could develop airway inflammation by repeated topical application followed by nasal inhalation of house dust mite (HDM) antigen (defined as a novel 'atopic march animal model'), and whether maintenance of an acidic SC environment by continuous application of acidic cream could interrupt the following atopic march...
July 4, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27297995/resolving-the-etiology-of-atopic-disorders-by-using-genetic-analysis-of-racial-ancestry
#17
REVIEW
Jayanta Gupta, Elisabet Johansson, Jonathan A Bernstein, Ranajit Chakraborty, Gurjit K Khurana Hershey, Marc E Rothenberg, Tesfaye B Mersha
Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic disorders of complex etiology. The frequently observed atopic march from early AD to asthma, allergic rhinitis, or both later in life and the extensive comorbidity of atopic disorders suggest common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African Americans when compared with European Americans...
September 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27274543/a-practical-overview-of-pediatric-atopic-dermatitis-part-2-triggers-and-grading
#18
Nanette B Silverberg
In part 2 of this 3-part series on atopic dermatitis (AD) in children, triggers for the appearance and flaring of AD are reviewed. The role of AD in the atopic march is explored. Furthermore, the usage of grading systems in the development of therapeutics and in clinical care is discussed. The natural history of AD has changed from improvement to 50% persistence and therefore it is important to council guardians and patients accordingly.
May 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27273433/study-of-the-atopic-march-development-of-atopic-comorbidities
#19
Lynda Schneider, Jon Hanifin, Mark Boguniewicz, Lawrence F Eichenfield, Jonathan M Spergel, Rada Dakovic, Amy S Paller
BACKGROUND: Atopic dermatitis (AD) is often the first step in the atopic march leading to the development of asthma or allergic rhinitis. The goal of this study was to determine whether early intervention with pimecrolimus limits the atopic march in infants with AD and to evaluate its efficacy and safety. METHODS: This was a 3-year double-blind study in which patients were randomized to pimecrolimus or vehicle and then open-label pimecrolimus for a planned further 3 years...
July 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27249439/sensitization-pattern-and-clinical-pecularities-of-food-allergy-in-georgia
#20
N Lomidze, T Abramidze, T Gotua, N Dolidze, M Gotua
The aim of our study was to investigate sensitization pattern to food allergens in different age groups of atopic patients in Georgia and reveal the associations between food sensitization and clinical manifestations of allergic disease reflecting the development of atopic march. 1000 patients (children-783, adult-217) with different clinical manifestations were involved in the study. Specific IgE antibodies to food mix, cow's milk, casein, egg, wheat, fish, nuts mixture and inhalant allergens were measured by using ImmunoCap (Phadia, Uppsala, Sweden)...
April 2016: Georgian Medical News
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