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Atopic march

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https://www.readbyqxmd.com/read/29777328/a-systematic-review-on-the-off-label-use-of-montelukast-in-atopic-dermatitis-treatment
#1
Weng Khong Chin, Shaun Wen Huey Lee
Background Atopic dermatitis (AD) is the most common form of eczema. As leukotriene mediators are involved in the inflammatory phase of atopic dermatitis, montelukast has been suggested as a possible therapy. Aim of the review To evaluate the safety and efficacy of montelukast off-label use for the treatment atopic dermatitis. Method A search was performed from database inception until March 2018 in six electronic databases for randomized-controlled-trials examining the use of montelukast for AD. Results Among 301 articles screened, 11 studies met the inclusion criteria and were included in the review...
May 18, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29763522/genetic-polymorphism-of-thymic-stromal-lymphopoietin-in-korean-patients-with-atopic-dermatitis-and-allergic-march
#2
E J Ko, W I Heo, K Y Park, M-K Lee, S J Seo
Thymic stromal lymphopoietin(TSLP) is recognized as key cytokine in T helper type 2 (Th 2) cell differentiation and contributes to the pathogenesis of atopic disease. The TSLP gene on chromosome 5q22.1 and atopic cytokine gene on 5q31 are adjacent to each other. Based on their genetic location, it is suggested that the TSLP gene is involved in the progression or activity of atopic disease. Genetic association studies involving TSLP single nucleotide polymorphisms (SNPs) and allergic rhinitis or asthma in different racial group have yielded disparate and inconsistent results...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29761483/epithelial-barrier-dysfunctions-in-atopic-dermatitis-a-skin-gut-lung-model-linking-microbiome-alteration-and-immune-dysregulation
#3
REVIEW
T H Zhu, T R Zhu, K A Tran, R K Sivamani, V Y Shi
Atopic dermatitis is a systemic disorder characterized by abnormal barrier function across multiple organ sites. Initial disruption in the skin epidermal barrier permits allergen sensitization and colonization by pathogens. This induces TH 2 inflammatory response and a thymic stromal lymphopoietin mediated pathway that further promotes barrier breakdown at distant sites including the intestinal and respiratory tract. Clinically, atopic dermatitis can progress from skin disease to food allergy, allergic rhinitis, and later asthma, a phenomenon commonly known as the atopic march...
May 15, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29750772/the-ins-and-outs-of-an-outside-in-view-of-allergies-atopic-dermatitis-and-allergy-prevention
#4
Marcus Shaker, Robert G P Murray, Julianne A Mann
PURPOSE OF REVIEW: The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march. RECENT FINDINGS: Atopic dermatitis is characterized by skin barrier defects (such as mutations in filaggrin), intrinsic proallergic T-helper cell 2 immune dysregulation, and skin microbiome alterations. These factors promote the development of food allergy and asthma...
May 9, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29680987/slit-s-prevention-of-the-allergic-march
#5
REVIEW
Federica Porcaro, Giovanni Corsello, Giovanni Battista Pajno
PURPOSE OF REVIEW: The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age. RECENT FINDINGS: Several studies show the efficacy and safety profile of sublingual immunotherapy (SLIT) for the treatment of respiratory allergy diseases, but few data are available on its effect of primary and secondary prevention of allergic disease...
April 21, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29676818/new-insights-into-the-phenotypes-of-atopic-dermatitis-linked-with-allergies-and-asthma-in-children-an-overview
#6
F Amat, A Soria, P Tallon, M Bourgoin-Heck, N Lambert, A Deschildre, J Just
Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy, and triggers. A group of difficult-to-manage patients characterized by early-onset AD and severe lifelong disease associated with allergic asthma and/or food allergy, has been identified. In this paper, we focus on these severe phenotypes, analyzing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta-analyses...
April 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29540642/dual-factors-may-be-necessary-for-development-of-atopic-march-in-early-infancy
#7
Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Masaya Takahashi, Hirotaka Minami
The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29413338/the-skin-as-a-target-for-prevention-of-the-atopic-march
#8
REVIEW
Adrian J Lowe, Donald Y M Leung, Mimi L K Tang, John C Su, Katrina J Allen
OBJECTIVE: Allergic diseases have increased dramatically in the developed world during the past few decades, yet the understanding of risk factors and effective prevention approaches remain limited. In this review, we summarize the evidence supporting the hypothesis that skin-barrier impairment and early-life atopic dermatitis (AD) could play a causal role in the development of sensitization and subsequent food allergies and allergic airways disease (allergic asthma and rhinitis). We further discuss the potential to target the skin barrier as a means to lower the incidence of allergic disease...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413336/the-atopic-march-critical-evidence-and-clinical-relevance
#9
REVIEW
David A Hill, Jonathan M Spergel
No abstract text is available yet for this article.
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413333/contribution-of-an-impaired-epithelial-barrier-to-the-atopic-march
#10
EDITORIAL
Elisabet Johansson, Gurjit K Khurana Hershey
No abstract text is available yet for this article.
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413332/the-atopic-march-fact-or-folklore
#11
EDITORIAL
William W Busse
No abstract text is available yet for this article.
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413331/can-the-atopic-march-be-predicted
#12
EDITORIAL
Maxwell M Tran, Malcolm R Sears
No abstract text is available yet for this article.
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29413330/is-eosinophilic-esophagitis-a-member-of-the-atopic-march
#13
EDITORIAL
David A Hill, Jonathan M Spergel
No abstract text is available yet for this article.
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29374025/a-8-year-population-based-cohort-study-of-irritable-bowel-syndrome-in-childhood-with-history-of-atopic-dermatitis
#14
Jeng-Dau Tsai, I-Chung Wang, Te-Chun Shen, Cheng-Li Lin, Chang-Ching Wei
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured...
April 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29315632/food-allergen-sensitized-ccr9-lymphocytes-enhance-airways-allergic-inflammation-in-mice
#15
L Castan, M-A Cheminant, L Colas, S Brouard, A Magnan, G Bouchaud
BACKGROUND: The mechanisms of the atopic march, characterized by a natural progression from food and cutaneous allergies to rhinitis and asthma, are still unknown. However, as several organs can be involved, chemokines and their receptors might be implicated in this process and may be instrumental factors. OBJECTIVES: We hypothesized that the T-cell gut-homing receptor CCR9 could be implicated in the evolution of allergic diseases. METHODS: We characterized the immune response and the role of CCR9 in a murine model combining food allergy to wheat gliadin and a model of acute airways inflammation in response to house dust mite...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29288652/co-activation-of-glucocorticoid-receptor-and-peroxisome-proliferator-activated-receptor-%C3%AE-in-murine-skin-prevents-worsening-of-atopic-march
#16
Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart N Lambrecht, Hamida Hammad, Karolien De Bosscher
Children with atopic dermatitis show an increased risk to develop asthma later in life, a phenomenon referred to as "atopic march," which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and peroxisome proliferator-activated receptor agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite via the skin, followed by exposure to house dust mite in lungs...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29238761/dupilumab-human-monoclonal-antibody-against-il-4r%C3%AE-for-moderate-to-severe-atopic-dermatitis
#17
D M Paton
Atopic dermatitis (AD) is one of the most common skin disorders with a prevalence of about 20% in children and affecting adults in significant numbers. Moderate to severe AD significantly impairs a patient's quality of life with severe pruritus as a major issue that impairs sleep and contributes to major psychological disturbances. Detailed studies of its pathogenesis have revealed that immune mechanisms are involved including activation of T helper type 2 cells (Th2). Dupilumab is a fully human Ig4 monoclonal antibody directed against the interleukin-4 receptor subunit α (IL-4Rα) of IL-4 and IL-13 receptors...
September 2017: Drugs of Today
https://www.readbyqxmd.com/read/29233462/recent-advancement-to-prevent-the-development-of-allergy-and-allergic-diseases-and-therapeutic-strategy-in-the-perspective-of-barrier-dysfunction
#18
REVIEW
Osamu Natsume, Yukihiro Ohya
Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march...
January 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29158868/prevalence-of-papular-urticaria-caused-by-flea-bites-and-associated-factors-in-children-1-6-years-of-age-in-bogot%C3%A3-d-c
#19
Evelyne Halpert, Elizabeth Borrero, Milciades Ibañez-Pinilla, Pablo Chaparro, Jorge Molina, Maritza Torres, Elizabeth García
Background: Papular urticaria is a chronic inflammatory disease caused by exposure to arthropod bites. The disease has been reported in children attending medical centers, but the causes as the risk factors associated with the disease have not been established. The objective of this study was to determine the prevalence of papular urticaria caused by flea bite and identify the risk factors in children between 1 to 6 years of age in Bogotá D.C, between March 2009 and June 2011. Methods: A cross-sectional, two-stage, clustered study using random probability sampling and stratified with proportional allocation was carried out in children (1-6 years of age) in educational institutions in Bogotá D...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29153857/predicting-the-atopic-march-results-from-the-canadian-healthy-infant-longitudinal-development-study
#20
Maxwell M Tran, Diana L Lefebvre, Christoffer Dharma, David Dai, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years. METHODS: Children completed skin prick testing at age 1 year. Children were considered sensitized if they produced a wheal 2 mm or larger than that elicited by the negative control to any of 10 inhalant or food allergens...
February 2018: Journal of Allergy and Clinical Immunology
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