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https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#1
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29164509/evolution-and-standardisation-of-techniques-in-single-incision-laparoscopic-bariatric-surgery
#2
P Praveen Raj, Siddhartha Bhattacharya, R Parthasarathi, P Senthilnathan, S Rajapandian, S Saravana Kumar, C Palanivelu
Bariatric surgery has proven benefits for morbid obesity and its associated comorbidities. Laparoscopic approach is well established for bariatric surgery. Single-incision laparoscopic surgery (SILS) offers even more minimally invasive approach for the same with the added advantage of better cosmesis. We have developed and standardised the SILS approach at our institute. We share our experience and technical "tips" and modifications which we have learnt over the years. Technical details of performing sleeve gastrectomy and Roux-en-Y gastric bypass with special attention to liver retraction, techniques of dissection in difficult areas, creation of anastomoses and suturing have all been described...
November 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29164288/correction-to-the-kidney-liver-index-surgery-and-c-reactive-protein-score-is-a-predictor-of-treatment-response-in-acute-prosthetic-joint-infection
#3
C Jiménez-Garrido, J M Gómez-Palomo, I Rodríguez-Delourme, F J Durán-Garrido, E Nuño-Álvarez, E Montañez-Heredia
There is an error in the name of one of the author in the original publication. The correct name is I Rodríguez-Delourme and not Delourne.
November 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29163804/circulating-tumor-cells-as-liquid-biomarker-for-high-hcc-recurrence-risk-after-curative-liver-resection
#4
Johann von Felden, Kornelius Schulze, Till Krech, Florian Ewald, Björn Nashan, Klaus Pantel, Ansgar W Lohse, Sabine Riethdorf, Henning Wege
Background: Early hepatocellular carcinoma (HCC) has a limited prognosis due to recurrence rates of more than 50% after liver resection. Recurrence within two years is believed to be caused by untraceable micro metastases at the time of resection. The objective of this study was to investigate EpCAM-positive circulating tumor cells (CTC) as liquid biomarker to identify patients with high risk of recurrence after liver resection. Methods: 61 patients undergoing resection between 2011 and 2015 were consecutively enrolled...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162562/metabolic-effects-of-bariatric-surgery
#5
REVIEW
Piriyah Sinclair, Neil Docherty, Carel W le Roux
BACKGROUND: Obesity can be defined as a chronic subcortical brain disease, as there is an important neurophysiological component to its etiology based on changes in the functioning of those areas of the brain controlling food intake and reward. Extensive metabolic changes accompany bariatric surgery-based treatment of obesity. Consequently, the term "metabolic" surgery is being increasingly adopted in relation to the beneficial effects these procedures have on chronic diseases like type 2 diabetes...
November 21, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29162088/prevention-of-glucocorticoid-associated-osteonecrosis-by-intravenous-administration-of-mesenchymal-stem-cells-in-a-rabbit-model
#6
Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio Kawahara
BACKGROUND: Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) have been conducted. Using a rabbit glucocorticoid-associated osteonecrosis model we administered green fluorescent protein (GFP)-labeled MSC intravenously to investigate their effect on osteonecrosis. METHODS: A rabbit osteonecrosis model in which methylprednisolone (MP) 20 mg/kg was injected into the gluteus of a Japanese white rabbit was used...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29162045/serial-pseudoprogression-of-metastatic-malignant-melanoma-in-a-patient-treated-with-nivolumab-a-case-report
#7
Yukinori Ozaki, Junichi Shindoh, Yuji Miura, Hiromichi Nakajima, Ryosuke Oki, Miyuki Uchiyama, Jun Masuda, Keiichi Kinowaki, Chihiro Kondoh, Yuko Tanabe, Tsuyoshi Tanaka, Shusuke Haruta, Masaki Ueno, Shigehisa Kitano, Takeshi Fujii, Harushi Udagawa, Toshimi Takano
BACKGROUND: Pseudoprogression refers to a specific pattern of response sometimes observed in malignant melanoma patients receiving treatment with immune-checkpoint inhibitors. Although cases with pseudoprogression documented once have been reported previously, there have been no case reports yet of pseudoprogression events documented twice during treatment. CASE PRESENTATION: A 55-year-old man underwent surgery for locally advanced esophageal malignant melanoma and received postoperative adjuvant interferon therapy...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161788/aggressive-supratentorial-ependymoma-rela-fusion-positive-with-extracranial-metastasis-a-case-report
#8
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome. For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of intra-axial neuroepithelial tumors are extremely rare. In this paper, we report a case of aggressive anaplastic ependymoma arising in the right frontoparietal lobe, which had genetically 1q25 gain, CDKN2A homozygous deletion, and L1CAM overexpression...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29160777/motion-compensation-with-skin-contact-control-for-high-intensity-focused-ultrasound-surgery-in-moving-organs
#9
Alessandro Diodato, Andrea Cafarelli, Andrea Schiappacasse, Selene Tognarelli, Gastone C Ciuti, Arianna Menciassi
High Intensity Focused Ultrasound (HIFU) is an emerging therapeutic solution that enables non-invasive treatment of several pathologies, mainly in oncology. On the other hand, accurate targeting of moving abdominal organs (e.g., liver, kidney, pancreas) is still an open challenge. This paper proposes a novel method to compensate the physiological respiratory motion of organs during HIFU procedures, by exploiting a robotic platform for ultrasound-guided HIFU surgery provided with a therapeutic annular phased array transducer...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160655/quality-of-life-and-adherence-in-liver-transplant-recipients
#10
Patrizia Burra, Alberto Ferrarese, Giuseppe Feltrin
The assessment of Quality of Life (QoL) after transplantation represents an ancillary tool to evaluate the efficacy of solid organ transplantation, in addition to graft and patient survival rates and complication. The global assessment of QoL after transplantation usually confirms the improvement when compared to pre-transplant setting. However, whereas significant improvement in physical activity has been widely reported, several studies have demonstrated that social domain and cognitive function do not reach the level of general population after surgery...
November 21, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29159979/ultrasound-microbubbles-enhance-the-activity-of-vancomycin-against-staphylococcus-epidermidis-biofilms-in-vivo
#11
Ying Dong, Junshuai Li, Pan Li, Jialin Yu
OBJECTIVES: Staphylococcus epidermidis is the predominant pathogen of device-associated infections. By forming biofilms on the device surface, S epidermidis has substantial resistance to antibiotics and is difficult to eradicate. This study aimed to explore the synergistic effect of ultrasound (US)-mediated microbubbles combined with vancomycin on S epidermidis biofilms in a rabbit model. METHODS: Two polytetrafluoroethene catheters with preformed S epidermidis biofilms were implanted subcutaneously in a rabbit, one on either side of the spine...
November 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29158365/phase-ii-trial-using-a-combination-of-oxaliplatin-capecitabine-and-celecoxib-with-concurrent-radiation-for-newly-diagnosed-resectable-rectal-cancer
#12
Emilio P Araujo-Mino, Yehuda Z Patt, Cristina Murray-Krezan, Joshua A Hanson, Pranshu Bansal, Ben J Liem, Ashwani Rajput, M Houman Fekrazad, Glenory Heywood, Fa Chyi Lee
LESSONS LEARNED: Colorectal cancers exhibit a high level of cyclooxygenase-2 (COX-2) expression with strong preclinical rationale for improved clinical outcomes with COX-2 inhibition. Celecoxib is a COX-2 inhibitor and we have shown that it can be safely combined with capecitabine and oxaliplatin as part of neoadjuvant treatment with radiation therapy (RT) in rectal cancer.There was a significant improvement in skin toxicity with this combination as compared with historical data. Considering the field has moved on to single-agent capecitabine, we believe future trials with capecitabine and celecoxib hold potential...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29158250/increased-liver-fatty-acid-uptake-is-partly-reversed-and-liver-fat-content-normalized-after-bariatric-surgery
#13
Heidi Immonen, Jarna C Hannukainen, Nobuyuki Kudomi, Jussi Pihlajamäki, Virva Saunavaara, Jukka Laine, Paulina Salminen, Terho Lehtimäki, Tam Pham, Patricia Iozzo, Pirjo Nuutila
OBJECTIVE: Changes in liver fatty acid metabolism are important in understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery. RESEARCH DESIGN AND METHODS: Liver fatty acid uptake (LFU), blood flow, and fat content (LFC) were measured in 25 obese subjects before bariatric surgery and 6 months after using positron emission tomography/computed tomography and MRS; 14 lean individuals served as the control subjects. RESULTS: The increased LFU in obese subjects was associated with body adiposity...
November 20, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29158141/patient-reported-tolerance-in-treatments-approved-in-neuroendocrine-tumors-a-national-survey-from-the-french-group-of-endocrine-tumors
#14
Arnaud Plante, Eric Baudin, Christine Do Cao, Olivia Hentic, Olivier Dubreuil, Eric Terrebonne, Victoire Granger, Denis Smith, Catherine Lombard-Bohas, Thomas Walter
BACKGROUND: Patients with advanced neuroendocrine tumors (NETs) benefit from an increasing number of treatments. The patient's preference could help physicians to choose among these options. Our patient-reported survey aims to compare the perceived tolerance of NETs treatments. METHODS: Patients treated by at least three different therapeutic options have evaluated their perceived tolerance from one (very good) to five (very poor) for each single treatment. Referent physician confirmed the type and ranking over time of each treatment...
November 17, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29157294/isolated-hepatoblastoma-arising-from-the-hepatogastric-ligament-a-case-report
#15
Ji Chen, Mengjiao Sun, Bin Sun, Jun Yi, Bin Jiang, Lei Huang
BACKGROUND: Almost all hepatoblastomas are isolated to the liver. Hepatoblastoma arising from and limited to extrahepatic tissue is an extremely rare clinical entity. CASE PRESENTATION: Here we present a case of a 7-year-old Chinese boy of Han ethnicity with hepatoblastoma originating from the hepatogastric ligament. A complete resection was performed and the entire course was uneventful. He received six cycles of postoperative chemotherapy and had no signs of recurrence for 3 years after surgery...
November 21, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29156640/clinical-beneficial-effects-of-using-crystalloid-only-in-recipients-of-living-donor-liver-transplantation
#16
Chia-Jung Huang, Kwok-Wai Cheng, Chao-Long Chen, Shao-Chun Wu, Tsung-Hsiao Shih, Sheng-Chun Yang, Sin-Ei Juang, Ying-En Lee, Chiu-En Huang, Bruno Jawan, Chih-Hsien Wang
OBJECTIVE: Liver transplantation (LT) is a major surgery associated with intraoperative massive fluid shift, which is usually replaced by crystalloid, 5% albumin (colloid) and blood products. We studied 15 patients from 477 consecutive recipients of adult living donor liver transplantation. Each patient received crystalloid only during LT. Whether LT provides any clinical benefit is not clear and must be determined. METHODS AND PATIENTS: The anesthesia records of 477 adult LDLT were reviewed retrospectively...
November 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156019/the-aspartate-transaminase-alanine-transaminase-deritis-ratio-predicts-mid-term-mortality-and-renal-and-respiratory-dysfunction-after-left-ventricular-assist-device-implantation
#17
Kevin Pilarczyk, Henning Carstens, Jens Heckmann, Ali Canbay, Achim Koch, Nikolaus Pizanis, Heinz Jakob, Markus Kamler
OBJECTIVES: Preoperative liver dysfunction is a well-known risk factor for adverse events after major surgery. However, there is only little data regarding the precise role of the Model of End-Stage Liver Disease (MELD) score and the De Ritis ratio (DRR, alanine transaminase/aspartate aminotransferase) as a predictor for outcome after left ventricular assist device (LVAD) implantation. METHODS: A retrospective analysis of all patients undergoing LVAD implantation at our institution between January 2012 and August 2014 was performed...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155069/antiviral-therapy-improves-survival-in-patients-with-hbv-infection-and-intrahepatic-cholangiocarcinoma-undergoing-liver-resection
#18
Zhengqing Lei, Yong Xia, Anfeng Si, Kui Wang, Jun Li, Zhenlin Yan, Tian Yang, Dong Wu, Xuying Wan, Weiping Zhou, Jingfeng Liu, Hongyang Wang, Wenming Cong, Mengchao Wu, Timothy M Pawlik, Wan Yee Lau, Feng Shen
BACKGROUND & AIMS: To examine the impact of antiviral therapy (AVT) on survival outcomes after liver resection (LR) for intrahepatic cholangiocarcinoma (ICC) patients with underlying HBV infection. METHODS: Data on 928 ICC patients with HBV infection who underwent LR at two medical centers between 2006 and 2011 were analyzed. Data on viral reactivation, tumor recurrence, cancer-specific survival (CSS) and overall survival (OS) were obtained. Survival rates were analyzed using the time-dependent Cox regression model adjusted for potential covariates...
November 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29154242/successful-hemihepatectomy-following-chemotherapy-for-primary-liver-lymphoma-case-report-and-review-of-literature
#19
Aleksander Skulimowski, Piotr Hogendorf, Grażyna Poznańska, Piotr Smolewski, Janusz Strzelczyk, Adam Durczynski
Non-Hodgkin lymphomas (NHL) comprise a heterogeneous group of B-cell and T-cell neoplasms. Diffuse large B-cell lymphoma (DLBCL), the most common type of NHL, accounts for around 30-40% of NHL cases. However, primary hepatic location of NHLs is rare and constitutes 0.01% of all NHL cases. Due to this rarity and a lack of large randomized trails, it is still unclear what treatment should be used for primary hepatic DLBCLs. In this study, we report of a female patient with primary hepatic DLBCL who was successfully treated with neoadjuvant chemotherapy and surgery...
October 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29154080/changes-in-gene-expression-in-small-bowel-neuroendocrine-tumors-associated-with-progression-to-metastases
#20
Kendall J Keck, Patrick Breheny, Terry A Braun, Benjamin Darbro, Guiying Li, Joseph S Dillon, Andrew M Bellizzi, Thomas M O'Dorisio, James R Howe
BACKGROUND: Small bowel neuroendocrine tumors (SBNETs) present frequently with metastases, yet little is known about the molecular basis of this progression. This study sought to identify the serial differential expression of genes between normal small bowel, primary small bowel neuroendocrine tumors, and liver metastases. METHODS: RNA isolated from matched normal small bowel tissue, primary small bowel neuroendocrine tumors, and liver metastases in 12 patients was analyzed with whole transcriptome expression microarrays and RNA-Seq...
November 16, 2017: Surgery
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