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https://www.readbyqxmd.com/read/28809447/pulmonary-delivery-of-tea-tree-oil-%C3%AE-cyclodextrin-inclusion-complexes-for-the-treatment-of-fungal-and-bacterial-pneumonia
#1
Miao Li, Lifei Zhu, Tongtong Zhang, Boming Liu, Lina Du, Yiguang Jin
OBJECTIVES: Bacterial pneumonia is a common cause of death worldwide. Tea tree oil (TTO) is a potent antimicrobial natural product, which is formulated in dry powder inhalers (DPIs) for the treatment of fungal and bacterial pneumonia. METHODS: Tea tree oil-β-cyclodextrin inclusion complexes (TTO-β-CD) were prepared and characterized. Aerodynamic properties of TTO-β-CD powders were measured. The rat models of fungal (Candida albicans) and bacterial (Acinetobacter baumannii) pneumonia were prepared...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28782167/plants-of-the-melaleuca-genus-as-antimicrobial-agents-from-farm-to-pharmacy
#2
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Elena Maria Varoni, Farukh Sharopov, Zubaida Yousaf, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Mehdi Sharifi-Rad, Mohammad Hossain Afdjei, Majid Sharifi-Rad, Marcello Iriti
Plants belonging to Melaleuca genus (Myrtaceae family) are native to Oceania, where they have been used for ages by Aborigine people in Australian traditional medicine, mainly because of their broad-spectrum antimicrobial activity. Although, M. linariifolia, M. dissitiflora, and other species of Melaleuca can also be used, the tea tree oil, an essential oil obtained from M. alternifolia shows the longest history of medicinal uses. Tea tree oil contains for the 80-90% several monoterpenes (terpinen-4-ol, α-terpinene, 1,8-cineol, p-cymene, α-terpineol, α-pinene, terpinolene, limonene, and sabinene)...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28772407/comparative-analysis-of-the-composition-and-active-property-evaluation-of-certain-essential-oils-to-assess-their-potential-applications-in-active-food-packaging
#3
Cornelia Vasile, Morten Sivertsvik, Amalia Carmen Miteluţ, Mihai Adrian Brebu, Elena Stoleru, Jan Thomas Rosnes, Elisabeta Elena Tănase, Waqas Khan, Daniela Pamfil, Călina Petruţa Cornea, Anamaria Irimia, Mona Elena Popa
The antifungal, antibacterial, and antioxidant activity of four commercial essential oils (EOs) (thyme, clove, rosemary, and tea tree) from Romanian production were studied in order to assess them as bioactive compounds for active food packaging applications. The chemical composition of the oils was determined with the Folin-Ciocâlteu method and gas chromatography coupled with mass spectrometry and flame ionization detectors, and it was found that they respect the AFNOR/ISO standard limits. The EOs were tested against three food spoilage fungi-Fusarium graminearum, Penicillium corylophilum, and Aspergillus brasiliensis-and three potential pathogenic food bacteria-Staphylococcus aureus, Escherichia coli, and Listeria monocytogenes-using the disc diffusion method...
January 7, 2017: Materials
https://www.readbyqxmd.com/read/28757937/a-comparative-study-of-antibacterial-and-anti-inflammatory-effects-of-mouthrinse-containing-tea-tree-oil
#4
C Salvatori, L Barchi, F Guzzo, M Gargari
The study evaluated the antibacterial and anti-inflammatory efficacy, domiciliary oral hygiene, of a mouthrinse containing Tea Tree Oil (TTO) comparing it with two mouthrinses containing chlorhexidine 0,12% respectively and essential oils, and a placebo. MATERIALS AND METHODS: A pilot study, randomized 4 × 4, controlled, cross-over, double-blind. 16 subjects with gingivitis (7 males and 9 females) aged 21-37 years, were randomly divided into four groups based on mouthwash that had to be used for domiciliary oral hygiene: mouthwash with essential oils, mouthwash with chlorhexidine 0,12 %, mouthwash containig tea tree oil and mouthwash placebo...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28749029/ecotype-variation-of-methyl-eugenol-content-in-tea-tree-melaleuca-alternifolia-and-m-linariifolia
#5
Mervyn Shepherd, Dale Savins, Ashley Dowell, Samantha Morrow, Gareth Allen, Ian Southwell
Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics and health-care. As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Consequently, its level has been restricted in some foodstuffs and cosmetics for some markets. In order to assess the potential to breed uniformly low methyl eugenol cultivars for an essential oil crop, tea tree, the source of "Oil of Melaleuca, terpinene-4-ol type", we examine levels in individual trees (n= 30) from two geographic regions and six terpene chemotypes...
July 27, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28728085/preparation-of-a-6-oh-quaternized-chitosan-derivative-through-click-reaction-and-its-application-to-novel-thermally-induced-polyelectrolyte-complex-hydrogels
#6
Yu Chen, Fengju Wang, Na Zhang, Yi Li, Bin Cheng, Yongfa Zheng
In the present study, a chitosan derivative with long chain quaternary ammonium locating grafted at 6-OH (CTS-6-QAS) was designed and prepared via a novel click reaction. The structure and thermal stability of the products of each step were determined with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Rheological tests indicate that CTS-6-QAS possesses excellent thermally induced hydrogel formation property in the presence of β-glycerophosphate (β-GP)...
July 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28634477/metabolomic-analysis-and-mode-of-action-of-metabolites-of-tea-tree-oil-involved-in-the-suppression-of-botrytis-cinerea
#7
Jiayu Xu, Xingfeng Shao, Yonghua Li, Yingying Wei, Feng Xu, Hongfei Wang
Tea tree oil (TTO), a volatile essential oil, has been widely used as an antimicrobial agent. However, the mechanism underlying TTO antifungal activity is not fully understood. In this study, a comprehensive metabolomics survey was undertaken to identify changes in metabolite production in Botrytis cinerea cells treated with TTO. Significant differences in 91 metabolites were observed, including 8 upregulated and 83 downregulated metabolites in TTO-treated cells. The results indicate that TTO inhibits primary metabolic pathways through the suppression of the tricarboxylic acid (TCA) cycle and fatty acid metabolism...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28614106/positive-patch-test-reactions-to-essential-oils-in-consecutive-patients-from-north-america-and-central-europe
#8
Erin M Warshaw, Kathryn A Zug, Donald V Belsito, Joseph F Fowler, Joel G DeKoven, Denis Sasseville, Howard I Maibach, C G Toby Mathias, Vincent A DeLeo, James S Taylor, Anthony F Fransway, James G Marks, Melanie D Pratt, Matthew J Zirwas, Johannes Geier, Wolfgang Uter
BACKGROUND: Synthetic fragrances and natural essential oils (EOs) are used in perfumery and found in various cosmetics. Essential oils are also increasingly used to promote wellness. In previous studies, the sensitization potential of some EOs has been identified; however, the current prevalence of sensitivity is largely unknown. OBJECTIVES: The aim of this study was to determine frequency of positive patch-test reactions to EOs tested in the baseline series, along with 3 fragrance markers (FMs) (fragrance mix I, fragrance mix II, and Myroxylon pereirae), in consecutive patients in the US/Canadian North American Contact Dermatitis Group (NACDG) (2009-2014) and the central European, trinational Information Network of Departments of Dermatology (IVDK) (2010-2014)...
July 2017: Dermatitis
https://www.readbyqxmd.com/read/28609410/effects-of-aroma-gargling-cold-water-gargling-and-wet-gauze-application-on-thirst-halitosis-and-sore-throat-of-patients-after-spine-surgery
#9
Kyung Eun Oh, Ae Ran Song, Sohyune R Sok
This study compared and examined the effects of aroma gargling, cold water gargling, and wet gauze application on thirst, halitosis, and sore throat in patients after spine surgery. A quasiexperimental pretest/posttest control group design was employed. Samples were total 70 patients (aroma gargling: 24 samples, cold gargling: 24 samples, and wet gauze: 22 samples) after spine surgery in K Hospital in Seoul, Korea. The aroma gargle solution as an experimental intervention was prepared by blending peppermint, tea tree, and lemon oils at a ratio of 1:2:2...
July 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/28551268/tea-tree-oil-exhibits-antifungal-activity-against-botrytis-cinerea-by-affecting-mitochondria
#10
Yonghua Li, Xingfeng Shao, Jiayu Xu, Yingying Wei, Feng Xu, Hongfei Wang
In order to investigate the effects of tea tree oil (TTO) on mitochondrial morphology and function in Botrytis cinerea, mycelia were treated with TTO at different concentrations. TTO at 2ml/l severely damaged mitochondria, resulting in matrix loss and increased mitochondrial irregularity. Mitochondrial membrane permeability was increased by TTO, as evidenced by a decrease in intracellular adenosine triphosphate (ATP) content and an increase in extracellular ATP content. Increasing concentrations of TTO decreased the activities of enzymes related to mitochondrial function and the tricarboxylic acid (TCA) cycle, affecting malic dehydrogenase, succinate dehydrogenase, ATPase, citrate synthetase, isocitrate dehydrogenase and α-ketoglutarate dehydrogenase, while sharply increasing the level of reactive oxygen species (ROS)...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28546125/molecular-cloning-and-functional-characterization-of-coft1-a-homolog-of-flowering-locus-t-ft-from-camellia-oleifera
#11
Hengjiu Lei, Shuchai Su, Luyi Ma, Yue Wen, Xiangnan Wang
FLOWERING LOCUS T (FT) is an important integrator of flowering genetic pathways and plays crucial roles in flowering transition. The tea-oil tree (Camellia oleifera Abel.) is a valuable woody oil crop, but the molecular mechanisms controlling flowering are still unclear. In this study, a FT-like gene, CoFT1, was isolated and characterized from C. oleifera. The CoFT1 protein was localized in the nucleus and cytoplasm of Arabidopsis protoplasts, and exhibited no transactivation activity in yeast cells. CoFT1 was highly expressed in mature leaves and reproductive organs, such as flower buds, flowers, flower organs, and young fruits...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28546114/melaleuca-alternifolia-essential-oil-prevents-alterations-to-purinergic-enzymes-and-ameliorates-the-innate-immune-response-in-silver-catfish-infected-with-aeromonas-hydrophila
#12
Matheus D Baldissera, Carine F Souza, Pedro H Doleski, Agueda C de Vargas, Marta M M F Duarte, Thiago Duarte, Aline A Boligon, Daniela B R Leal, Bernardo Baldisserotto
Aeromonas hydrophila infection represents a major impediment to the development of aquaculture, leading to important economic losses. Over the last few years, different methods have been used to counteract and minimize the negative effects of this infection, such as the use of Melaleuca alternifolia essential oil, popularly known as tea tree oil (TTO), that possess a bactericide action against A. hydrophila. The purinergic system develops an important role in the inflammatory response, principally due to involvement of adenosine triphosphate (ATP) in the inflammatory process, as well as by the anti-inflammatory properties of adenosine (Ado), a molecule that is controlled by NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) enzymes...
May 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28513067/interventions-for-cutaneous-molluscum-contagiosum
#13
REVIEW
Johannes C van der Wouden, Renske van der Sande, Emma J Kruithof, Annet Sollie, Lisette Wa van Suijlekom-Smit, Sander Koning
BACKGROUND: Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking.This is an update of a Cochrane Review first published in 2006, and updated previously in 2009. OBJECTIVES: To assess the effects of specific treatments and management strategies, including waiting for natural resolution, for cutaneous, non-genital molluscum contagiosum in people without immune deficiency...
May 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28512603/bactericidal-activity-of-herbal-volatile-oil-extracts-against-multidrug-resistant-acinetobacter-baumannii
#14
Amornrat Intorasoot, Piyaorn Chornchoem, Siriwoot Sookkhee, Sorasak Intorasoot
AIM: The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (Alpinia galanga Linn.), ginger (Zingiber officinale), plai (Zingiber cassumunar Roxb.), lime (Citrus aurantifolia), kaffir lime (Citrus hystrix DC.), sweet basil (Ocimum basilicum Linn.), tree basil (Ocimum gratissimum), lemongrass (Cymbopogon citratus DC.), clove (Syzygium aromaticum), and cinnamon (Cinnamomum verum) against four standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and 30 clinical isolates of multidrug-resistant A...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28464710/salvaging-cochlear-implant-after-wound-infection-well-worth-a-try
#15
Shalabh Sharma, Anandita Gupta, Khyati Bhatia, Asish Kumar Lahiri, Satinder Singh
BACKGROUND: Cochlear implant (CI)-related wound infections are known to happen even years after the implant procedure and present a challenging clinical situation. Due to the formation of biofilm on the implant surface such infections are difficult to eradicate. Invariably explantation of the device is required for wound healing. METHOD: A 10-year-old patient presented with recurrent CI-related wound infection 8 years after implantation. The implant was salvaged with wound debridement and treating it with tea tree oil which is known for its biofilm eradicating properties...
May 3, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28209019/efficacy-of-specific-plant-products-on-microorganisms-causing-dental-caries
#16
M Rajini Kanth, A Ravi Prakash, G Sreenath, Vikram Simha Reddy, S Huldah
INTRODUCTION: Dental caries and periodontal diseases are the most common oral diseases seen globally, both in developed and developing countries. Oral microorganisms that is gram positive and gram negative bacteria are known to be involved in causation of these diseases. Nowadays commercially available dentrifices and mouth rinses are known to contain ingredients that can alter the oral microbial flora and have undesirable side effects such as vomiting, diarrhoea, disarrangement of oral, intestinal flora and tooth staining...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28177805/effects-and-possible-mechanism-of-tea-tree-oil-against-botrytis-cinerea-and-penicillium-expansum-in-vitro-and-in-vivo-test
#17
Yonghua Li, Xingfeng Shao, Jiayu Xu, Yingying Wei, Feng Xu, Hongfei Wang
The purpose of this study was to investigate the antifungal activities and possible mechanisms of tea tree oil (TTO) against Botrytis cinerea and Penicillium expansum in vitro and in vivo. The results show that TTO exhibits dose-dependent antifungal activity against both pathogens, but P. expansum is less sensitive than B. cinerea to TTO not only in the in vitro test but also in artificially inoculated cherry fruits. TTO vapor treatment reduced the decay caused by these pathogens in inoculated cherry fruits, but the effect on P...
March 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28128086/vesicular-contact-reaction-may-progress-into-erythema-multiforme
#18
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28124137/evaluation-of-the-effectiveness-of-tea-tree-oil-in-treatment-of-acanthamoeba-infection
#19
Edward Hadaś, Monika Derda, Marcin Cholewiński
Eye diseases caused by amoebae from the genus Acanthamoeba are usually chronic and severe, and their treatment is prolonged and not very effective. The difficulties associated with therapy have led to attempts at finding alternative treatment methods. Particularly popular is searching for cures among drugs made of plants. However, no substances with total efficacy in treating Acanthamoeba keratitis have been identified.Results of our semi in vivo studies of tea tree oil simulating eyeball infection demonstrated 100% effectiveness in the case of both trophozoites and cysts of amoebae from the genus Acanthamoeba...
March 2017: Parasitology Research
https://www.readbyqxmd.com/read/28120012/erratum-to-the-dynamics-and-mechanism-of-the-antimicrobial-activity-of-tea-tree-oil-against-bacteria-and-fungi
#20
Wen-Ru Li, Hai-Ling Li, Qing-Shan Shi, Ting-Li Sun, Xiao-Bao Xie, Bin Song, Xiao-Mo Huang
No abstract text is available yet for this article.
January 24, 2017: Applied Microbiology and Biotechnology
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