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Endobronchial brachytherapy

E Donovan, E Timotin, T Farrell, B Donde, S Puksa, R Sur
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Ali Hosni, Andrea Bezjak, Alexandra Rink, Kasia Czarnecka, Andrew McPartlin, Susan Patterson, Elantholiparameswaran Saibishkumar
Purpose. To report our experience with high dose rate endobronchial brachytherapy (HDR-EBBT) and to assess its efficacy and tolerability with possibility of its use in selected cases with curative intent. Method. Retrospective review of patients with endobronchial tumors treated at our institution in 2007-2013 with HDR-EBBT. Subjective response and treatment related toxicity were extracted from patients' records. Clinical response was evaluated by chest CT +/- bronchoscopy 2-3 months after treatment. Local control (LC) and overall survival (OS) were analyzed...
2016: Lung Cancer International
Naoya Murakami, Kazuma Kobayashi, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Ken Harada, Mayuka Yamada, Shuhei Sekii, Kana Takahashi, Rei Umezawa, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Jun Itami
[This corrects the article DOI: 10.5114/jcb.2015.54968.].
April 2016: Journal of Contemporary Brachytherapy
Kazuma Kobayashi, Naoya Murakami, Koji Inaba, Akihisa Wakita, Satoshi Nakamura, Hiroyuki Okamoto, Jun Sato, Rei Umezawa, Kana Takahashi, Hiroshi Igaki, Yoshinori Ito, Naoyuki Shigematsu, Jun Itami
PURPOSE: Small organ subvolume irradiated by a high-dose has been emphasized to be associated with late complication after radiotherapy. Here, we demonstrate a potential use of surface-based, non-rigid registration to investigate how high-dose volume topographically correlates with the location of late radiation morbidity in a case of tracheobronchial radiation stenosis. MATERIAL AND METHODS: An algorithm of point set registration was implemented to handle non-rigid registration between contour points on the organ surfaces...
April 2016: Journal of Contemporary Brachytherapy
Naoya Murakami, Kazuma Kobayashi, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Ken Harada, Mayuka Yamada, Shuhei Sekii, Kana Takahashi, Rei Umezawa, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Jun Itami
PURPOSE: The endobronchial brachytherapy (EBBT) is an established treatment method for tumors of the tracheobronchial system, however, little is known about the tolerance dose for organ at risk (OAR) in EBBT. The purpose of this study is to analyze patients with superficial bronchial carcinoma treated with definitive EBBT, and to investigate a relationship between late complications and dose for OAR. MATERIAL AND METHODS: Endobronchial brachytherapy was performed 6 Gy per fraction for three to four fractions with or without external beam radiation therapy (EBRT)...
October 2015: Journal of Contemporary Brachytherapy
Janusz Skowronek
The majority of patients with lung cancer are diagnosed with clinically advanced disease. Many of these patients have a short life expectancy and are treated with palliative aim. Because of uncontrolled local or recurrent disease, patients may have significant symptoms such as: cough, dyspnea, hemoptysis, obstructive pneumonia, or atelectasis. Brachytherapy is one of the most efficient methods in overcoming difficulties in breathing that is caused by endobronchial obstruction in palliative treatment of bronchus cancer...
August 2015: Journal of Contemporary Brachytherapy
A Stewart, B Parashar, M Patel, D O'Farrell, M Biagioli, P Devlin, S Mutyala
PURPOSE: To update brachytherapy recommendations for pretreatment evaluation, treatment, and dosimetric issues for thoracic brachytherapy for lung cancer. METHODS AND MATERIALS: Members of the American Brachytherapy Society with expertise in thoracic brachytherapy updated recommendations for thoracic brachytherapy based on literature review and clinical experience. RESULTS: The American Brachytherapy Society consensus guidelines recommend the use of endobronchial brachytherapy for disease palliation in patients with central obstructing lesions, particularly in patients who have previously received external beam radiotherapy...
January 2016: Brachytherapy
Mira Goldberg, Emilia Timotin, Tom Farrell, Serge Puksa, Bernard Donde, Ranjan Sur
PURPOSE: Obstructive symptoms that affect quality of life (QOL) are commonly caused by endobronchial disease in many patients with locally advanced, inoperable lung cancer. High-dose-rate endobronchial brachytherapy (HDREBBT) has been used to palliate these symptoms, yet its role is not well defined in the literature. METHODS AND MATERIALS: Ninety-eight patients with locally advanced, inoperable lung cancer received HDREBBT. They were prospectively followed for survival, QOL, and toxicity endpoints...
September 2015: Brachytherapy
Kamran Mahmood, Momen M Wahidi
Central airway obstruction (CAO) is seen in malignant and nonmalignant airway disorders and can lead to significant morbidity and mortality. Endobronchial ablative therapies are used in conjunction with mechanical debridement to achieve hemostasis and restore airway patency. These therapies can be classified into modalities with immediate or delayed effect. Therapies with immediate effect include heat therapies (such as electrocautery, argon plasma coagulation, and laser) and cryorecanalization using a cryoprobe for tissue extraction...
December 2014: Seminars in Respiratory and Critical Care Medicine
Marcin Sawicki, Damian Kazalski, Jarosław Lyczek, Lukasz Kowalik
PURPOSE: To present comparison of treatment plans made by using 2D and 3D methods in the planning system, as well as to assess the quality of treatment plans using the 2D and 3D methods. MATERIAL AND METHODS: The studies involved a group of 31 patients with advanced lung cancer treated in the Brachytherapy Department of the Subcarpathian Cancer Center in Brzozów from 2011 to 2013. In total, 31 patients and 76 treatment plans were analyzed. We compared coverage of PTV planned in 3D and 2D...
October 2014: Journal of Contemporary Brachytherapy
L Lefebvre, M Doré, P Giraud
Radiotherapy is used for inoperable lung cancers, sometimes in association with chemotherapy. Outcomes of conventional radiotherapy are disappointing. New techniques improve adaptation to tumour volume, decrease normal tissue irradiation and lead to increasing tumour dose with the opportunity for improved survival. With intensity-modulated radiation therapy, isodoses can conform to complex volumes. It is widely used and seems to be indicated in locally advanced stages. Its dosimetric improvements have been demonstrated but outcomes are still heterogeneous...
October 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Jung Seop Eom, BoKyong Kim, Hojoong Kim, Kyeongman Jeon, Sang-Won Um, Won-Jung Koh, Gee Young Suh, Man Pyo Chung, O Jung Kwon
BACKGROUND AND OBJECTIVE: Radiotherapy is usually administered to the central airway in patients with unresectable adenoid cystic carcinoma (ACC). The purpose of this study was to describe the outcomes of endobronchial intervention in patients with airway stenosis following radiotherapy for ACC. Moreover, we investigated the incidence and contributing factors for airway stenosis following radiotherapy for ACC. METHODS: Forty-seven patients with ACC, who underwent radiotherapy of the tracheobronchial tree from January 1995 to December 2011, were reviewed retrospectively...
August 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
George Rodrigues, Gregory M M Videtic, Ranjan Sur, Andrea Bezjak, Jeffrey Bradley, Carol A Hahn, Corey Langer, Keith L Miller, Benjamin J Moeller, Kenneth Rosenzweig, Benjamin Movsas
PURPOSE: To provide guidance to physicians and patients with regard to the use of external beam radiotherapy, endobronchial brachytherapy, and concurrent chemotherapy in the setting of palliative thoracic treatment for lung cancer, based on available evidence complemented by expert opinion. METHODS AND MATERIALS: A Task Force authorized by the American Society for Radiation Oncology (ASTRO) Board of Directors synthesized and assessed evidence from 3 systematic reviews on the following topics: (1) dose fractionation in thoracic external beam radiotherapy (EBRT); (2) clinical utility of initial and salvage endobronchial brachytherapy (EBB); and (3) use of concurrent chemotherapy (CC) with palliative thoracic radiotherapy...
April 2011: Practical Radiation Oncology
Feras Oskan, Christine Kornhuber, Grit Krause, Dirk Vordermark
The co-incidence of synchronous intraepithelial neoplasia and early stage invasive lung cancer is not a rare phenomenon. The need for curative treatment and the invasive potential of squamous cell pulmonary carcinoma in situ have been a topic of controversy. Surgical resection still remains the treatment of choice. Varieties of endoscopic techniques such as brachytherapy were developed as an alternative to surgery in selected patients. External beam radiation therapy has been used traditionally in combination with endobronchial brachytherapy in the treatment of roentgenographically occult lung cancer, and can be offered for all patients, but is handicapped, because these tumors are radiographically invisible...
2013: Radiation Oncology
Joseph C Seaman, Ali I Musani
Endobronchial ablative therapies are used to address a variety of malignant and benign airway lesions. By utilizing endobronchial ablative techniques patients with symptomatic airway lesions may receive significant symptom improvement, improved quality of life, and improved life expectancy. Endobronchial ablative therapies include laser, electrocautery, argon plasma coagulation, cryotherapy, brachytherapy, and photodynamic therapy. The choice to use one therapy versus another depends on technical and patient specific factors...
September 2013: Clinics in Chest Medicine
Bojan Zaric, Ralf Eberhardt, Felix Herth, Vladimir Stojsic, Vladimir Carapic, Zora Pavlovic Popovic, Branislav Perin
Endobronchial ultrasound (EBUS) in recent years has become a routine diagnostic procedure in bronchology. Linear EBUS shows high diagnostic yield in evaluation of mediastinal lymph nodes. It is mainly used for nodal evaluation in lung cancer, but has also proven to be efficient in diagnostic evaluation of mediastinal masses. This technique has been shown to be complementary to mediastinoscopy. In combination with PET and rapid on site cytology (ROSE), the diagnostic yield of EBUS is significantly higher. Radial EBUS is used for diagnosis of peripheral lung lesions...
September 2013: Expert Review of Medical Devices
Kenneth E Rosenzweig, Joe Yujiao Chang, Indrin J Chetty, Roy H Decker, Mark E Ginsburg, Larry L Kestin, Feng-Ming Spring Kong, Brian E Lally, Corey J Langer, Benjamin Movsas, Gregory M M Videtic, Henning Willers
Radiation therapy plays a potential curative role in the treatment of patients with non-small-cell lung cancer with locoregional disease who are not surgical candidates and a palliative role for patients with metastatic disease. Stereotactic body radiation therapy is a relatively new technique in patients with early-stage non-small-cell lung cancer. A trial from RTOG(®) reported >97% local control at 3 years. For patients with locally advanced disease, thoracic radiation to a dose of 60 Gy remains the standard of care...
September 2013: Journal of the American College of Radiology: JACR
Janusz Skowronek, Tomasz Piorunek, Marek Kanikowski, Adam Chicheł, Grzegorz Bielęda
PURPOSE: The aim of this work was to evaluate outcomes after definitive high-dose-rate endobronchial brachytherapy (HDR-BT) for lung cancer. METHODS AND MATERIAL: We treated 34 patients after surgery for lung cancer, without nodal or distant metastases, with HDR-BT. Two groups were analyzed, one with local recurrence in stump after prior surgery (n = 13) and a second with nonradical primary lobar resection found in histopathologically positive margins (n = 21)...
November 2013: Brachytherapy
Nathalie Rochet, Henrik Hauswald, Eva Maria Stoiber, Frank W Hensley, Heinrich D Becker, Juergen Debus, Katja Lindel
BACKGROUND: To retrospectively evaluate the outcome of patients with inoperable non-small-cell lung cancer treated with primary external beam radiotherapy combined with high-dose-rate endobronchial brachytherapy boost. PATIENTS AND METHODS: Between 1988 and 2005, 35 patients with non-small-cell lung cancer (stage I-III) ineligible for surgical resection and/or chemotherapy, were primarily treated with external beam radiotherapy with a median total dose of 50 Gy (range, 46-60)...
March 2013: Tumori
Jamsak Tscheikuna, Supparerk Disayabutr, Chumpot Kakanaporn, Lalida Tuntipumi-Amorn, Yaowalak Chansilpa
UNLABELLED: Benign complex tracheobronchial stenosis (BCTS) is a tracheobronchial stenosis that is longer than 1 cm or has more than one site of stenotic area. The most common etiology of the stenosis is endobronchial tuberculosis. BCTS causes challenge in diagnosis and management because of nonspecific presentation and usually precluded surgical treatment. Available interventional bronchoscopic techniques fail to manage BCTS because of high rate of restenosis. Experience in using HDR brachytherapy to prevent restenosis in two cases of BCTS is reported...
February 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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