keyword
https://read.qxmd.com/read/38525642/treating-drug-resistant-tuberculosis-in-an-era-of-shorter-regimens-insights-from-rural-south-africa
#21
JOURNAL ARTICLE
J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort
BACKGROUND: Progressive interventions have recently improved programmatic outcomes in drug-resistant tuberculosis (DR-TB) care in South Africa (SA). Amidst these, a shorter regimen was introduced in 2017 with weak evidence, and has shown mixed results. Outcomes still fall short of national targets, and the coronavirus disease 2019 pandemic has undermined progress to date. OBJECTIVES: To describe the outcomes of participants treated for DR-TB using a shorter, compared with a longer, regimen in a deeply rural SA setting, and to explore other factors affecting these outcomes...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38525474/prevalence-of-smear-positive-rifampicin-resistant-mycobacterium-tuberculosis-and-related-factors-among-residents-with-cough-in-northern-ethiopian-refugee-health-facilities
#22
JOURNAL ARTICLE
Hailemariam Mezgebe, Teklay Gebrecherkos, Dawit Gebreegziabiher Hagos, Saravanan Muthupandian
PURPOSE: To ascertain the prevalence of Mycobacterium tuberculosis (M.tb) among refugees suspected of tuberculosis (TB) and related risk factors, including smear-positive and Rifampicin-resistant M.tb. METHODS: A cross-sectional study was conducted between January 2020 and May 2020 among 384 refugees in four refugee camps in Northwest Tigray, Ethiopia. Socio-demographic and clinical data were collected from refugees with a history of cough for more than two weeks prospectively...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38524650/coexistence-of-ovarian-cancer-and-peritoneal-tuberculosis-a-case-report
#23
JOURNAL ARTICLE
Akitoshi Yamamura, Kentaro Sekiyama, Miki Otsuki, Akiko Abe, Yuki Kashihara, Yuki Kozono, Akiko Okuda, Yumiko Yoshioka, Toshihiro Higuchi
Peritoneal tuberculosis (TB) is known to mimic advanced ovarian cancer. In this case report, we describe a unique case of ovarian cancer (endometrioid carcinoma grade 3) at the International Federation of Gynecology and Obstetrics (FIGO) stage IC1 with pulmonary and peritoneal TB, which was suspected preoperatively to be a coexistence of advanced ovarian cancer and pulmonary TB. A 68-year-old woman presented with a prominent abdominal mass and fever. Laboratory investigations, imaging, and sputum analysis indicated a probable diagnosis of ovarian cancer at FIGO stage IIIC, characterized by peritoneal dissemination and para-aortic lymph node metastasis, which was further complicated by coexisting pulmonary TB...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38522174/in-vitro-stimulation-with-nontuberculous-mycobacteria-induced-a-stronger-cytokine-response-in-leukocytes-isolated-from-individuals-with-latent-tuberculosis-compared-to-those-isolated-from-active-tuberculosis-or-cystic-fibrosis-patients
#24
JOURNAL ARTICLE
Hardis Rabe, Elisabeth Lönnermark, Ewa Johansson, Marita Gilljam, Bodil Jönsson
Mycobacterium tuberculosis and opportunistic environmental non-tuberculous mycobacteria (NTM) can cause severe infection. Why latent tuberculosis infection advances to active disease, and why some individuals with cystic fibrosis (CF) develop pulmonary infections with NTM is still poorly understood. The aim of this study was to investigate the effector function of peripheral blood mononuclear cells (PBMC) from individuals with active or latent tuberculosis, individuals with CF with or without pulmonary NTM-infection and healthy controls, by measuring cytokine response to in vitro stimulation with different species of NTMs...
March 20, 2024: Tuberculosis
https://read.qxmd.com/read/38521643/a-review-of-host-specific-diagnostic-and-surrogate-biomarkers-in-children-with-pulmonary-tuberculosis
#25
REVIEW
Junaid Shaik, Manormoney Pillay, Prakash Jeena
BACKGROUND: Tuberculosis (TB) is one of the most common causes of mortality globally with a steady rise in paediatric cases in the past decade. Laboratory methods of diagnosing TB and monitoring response to treatment have limitations. Current research focuses on interrogating host- and/or pathogen-specific biomarkers to address this problem. METHODS: We reviewed the literature on host-specific biomarkers in TB to determine their value in diagnosis and treatment response in TB infected and HIV/TB co-infected children on anti-tuberculosis treatment...
February 17, 2024: Paediatric Respiratory Reviews
https://read.qxmd.com/read/38521375/development-of-a-self-microemulsifying-drug-delivery-system-to-deliver-delamanid-via-a-pressurized-metered-dose-inhaler-for-treatment-of-multi-drug-resistant-pulmonary-tuberculosis
#26
JOURNAL ARTICLE
Himanshu Paliwal, Titpawan Nakpheng, Pijush Kumar Paul, K Prem Ananth, Teerapol Srichana
Tuberculosis (TB) is a serious health issue that contributes to millions of deaths throughout the world and increases the threat of serious pulmonary infections in patients with respiratory illness. Delamanid is a novel drug approved in 2014 to deal with multi-drug resistant TB (MDR-TB). Despite its high efficiency in TB treatment, delamanid poses delivery challenges due to poor water solubility leading to inadequate absorption upon oral administration. This study involves the development of novel formulation-based pressurized metered dose inhalers (pMDIs) containing self-microemulsifying mixtures of delamanid for efficient delivery to the lungs...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38518936/peptide-functionalized-chitosan-based-microcapsules-for-dual-active-targeted-treatment-of-lung-infections
#27
JOURNAL ARTICLE
Delia Mihaela Rata, Anca Niculina Cadinoiu, Leonard Ionut Atanase, Marcel Popa, Cosmin Teodor Mihai, Gabriela Vochita
Lung infections, such as: pneumonia, chronic obstructive cystic fibrosis, tuberculosis are generally caused by viruses, bacteria and fungi. As these infections are very difficult to treat, new therapeutic approaches are investigated in order to maximize the efficiency of the treatment and to reduce the major complications that can occur. The main objective of this study was focused on the preparation of drug-loaded peptides-functionalized microcapsules, obtained by a double emulsion, based on carboxylated chitosan (CMCS), poly(vinyl alcohol) (PVA) and an activator [4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride] (DMT-MM), for the dual active targeting and treatment of pulmonary infections...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38518684/non-tuberculous-mycobacterial-isolates-from-panama-a-retrospective-5-year-analysis-2017-2021
#28
JOURNAL ARTICLE
Prudencio González, Juan Domínguez, Pedro Del Cid, Samantha Rosas, Ariel Magallón-Tejada
BACKGROUND: The genus Mycobacterium includes well-known bacteria such as M. tuberculosis causing tuberculosis and M. leprae causing leprosy. Additionally, various species collectively termed non-tuberculous mycobacteria (NTM) can cause infections in humans and animals, affecting individuals across all age groups and health conditions. However, information on NTM infection prevalence in Panama is limited. METHODS: This study conducted a retrospective analysis of clinical records from 2017 to 2021, specifically focusing on patients with NTM isolates...
March 5, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38518474/primary-extrahepatic-hydatid-cyst-of-the-thigh-an-unusual-presentation-of-sciatica-a-case-report-of-a-diagnostic-challenge
#29
Ahmed Zendeoui, Mohamed Amine Gharbi, Mouadh Nefiss, Mohamed Hedi Ezzine, Anis Tborbi, Ramzi Bouzidi
INTRODUCTION: Sciatica, a condition characterized by pain along the sciatic nerve distribution, is commonly associated with nerve compression or irritation. However, its etiology can vary, including rare non-spinal causes such as hydatid cysts. We present a case of hydatid cyst in the thigh causing sciatica-like symptoms, highlighting the diagnostic challenges and management approach. CASE PRESENTATION: A 40-year-old patient with a history of pulmonary tuberculosis presented with persistent lumbosciatic pain despite conservative treatment...
March 20, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38518147/integrated-nursing-and-psychological-intervention-for-tuberculosis-complicated-by-lung-cancer-clinical-efficacy
#30
JOURNAL ARTICLE
Wei Yuan, Linlin Chai, Jing Wang, Cuifang Liu, Zhibin Jiang, Mo Deng, Hui Wang
CONTEXT: The incidence of tuberculosis (TB) complicated by lung cancer has been increasing yearly worldwide. The overlapping effects of these two diseases leads to difficulties in clinical treatment and care. Single-care modalities fail to meet the clinical-care requirements of these complex diseases for both psychological and physical treatment. OBJECTIVE: The study intended to evaluate the clinical efficacy of integrated nursing plus a psychological intervention for patients with TB complicated by lung cancer...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38518003/multidrug-resistant-mycobacterium-tuberculosis-transmission-in-shandong-china
#31
JOURNAL ARTICLE
Yingying Li, Yifan Li, Tingting Wang, Yameng Li, Ningning Tao, Xianglong Kong, Yuzhen Zhang, Qilin Han, Yao Liu, Huaichen Li
Multidrug-resistant tuberculosis (MDR-TB) has imposed a significant economic and health burden worldwide, notably in China. Using whole genome sequence, we sought to understand the mutation and transmission of MDR-TB in Shandong. A retrospective study of patients diagnosed with pulmonary tuberculosis in Shandong from 2009 to 2018 was conducted. To explore transmission patterns, we performed whole genome sequencing on MDR-TB isolates, identified genomic clusters, and assessed the drug resistance of TB isolates...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517152/prevalence-and-risk-factors-for-chronic-pulmonary-aspergillosis-in-chronic-obstructive-pulmonary-disease-patients-with-acute-exacerbations
#32
JOURNAL ARTICLE
Jayabharathi Palanivel, Madhusmita Mohanty Mohapatra, Manju Rajaram, Debasis Gochhait, Sunitha Vellathussery Chakkalakkoombil, Rakesh Singh
Chronic obstructive pulmonary disease (COPD) patients often experience acute exacerbations requiring hospitalization. Recently, attention has focused on Aspergillus sensitization in the airways of these COPD patients. This study aimed to assess the prevalence of chronic pulmonary aspergillosis (CPA) in COPD patients with acute exacerbations and identify associated risk factors. A cross-sectional descriptive study was conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research from January 2021 to June 2022...
March 21, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38516988/scrofuloderma-of-the-chest-with-mediastinal-tb
#33
Vanessa Bustamante Estrada, Ana Claudia Lada Lemos, Pedro Machado Luz, Iara Regina Siqueira Lucena, Valentina Coutinho Baldoto Gava Chakr, Anneliese Hoffmann
Cutaneous tuberculosis is a rare manifestation of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis in most cases and rarely by Mycobacterium bovis. Diagnosis may be challenging due to a wide range of clinical findings and similarities to other chronic dermatoses, leading to delayed treatment. We present a case of scrofuloderma in a 4-year-old girl that arose from a contiguous spread from the anterior mediastinum with associated pulmonary involvement.
March 22, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38516785/cost-effectiveness-of-active-tuberculosis-screening-among-high-risk-populations-in-low-tuberculosis-incidence-countries-a-systematic-review-2008-to-2023
#34
JOURNAL ARTICLE
Nino Gogichadze, Arnau Sagrera, José Ángel Vicente, Joan-Pau Millet, Francesc López-Seguí, Cristina Vilaplana
BackgroundIn countries with a low TB incidence (≤ 10 cases/100,000 population), active pulmonary tuberculosis (PTB) mostly affects vulnerable populations with limited access to healthcare. Thus, passive case-finding systems may not be successful in detecting and treating cases and preventing further transmission. Active and cost-effective search strategies can overcome this problem.AimWe aimed to review the evidence on the cost-effectiveness (C-E) of active PTB screening programmes among high-risk populations in low TB incidence countries...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38515959/prediction-of-tuberculosis-from-lung-tissue-images-of-diversity-outbred-mice-using-jump-knowledge-based-cell-graph-neural-network
#35
JOURNAL ARTICLE
Vasundhara Acharya, Diana Choi, BüLENT Yener, Gillian Beamer
Tuberculosis (TB), primarily affecting the lungs, is caused by the bacterium Mycobacterium tuberculosis and poses a significant health risk. Detecting acid-fast bacilli (AFB) in stained samples is critical for TB diagnosis. Whole Slide (WS) Imaging allows for digitally examining these stained samples. However, current deep-learning approaches to analyzing large-sized whole slide images (WSIs) often employ patch-wise analysis, potentially missing the complex spatial patterns observed in the granuloma essential for accurate TB classification...
2024: IEEE Access: Practical Innovations, Open Solutions
https://read.qxmd.com/read/38515745/-mycobacterium-tuberculosis-dependent-monocyte-expression-quantitative-trait-loci-cytokine-production-and-tb-pathogenesis
#36
JOURNAL ARTICLE
Hyejeong Hong, Kimberly A Dill-McFarland, Jason D Simmons, Glenna J Peterson, Penelope Benchek, Harriet Mayanja-Kizza, W Henry Boom, Catherine M Stein, Thomas R Hawn
INTRODUCTION: The heterogeneity of outcomes after Mycobacterium tuberculosis (Mtb) exposure is a conundrum associated with millennia of host-pathogen co-evolution. We hypothesized that human myeloid cells contain genetically encoded, Mtb-specific responses that regulate critical steps in tuberculosis (TB) pathogenesis. METHODS: We mapped genome-wide expression quantitative trait loci (eQTLs) in Mtb-infected monocytes with RNAseq from 80 Ugandan household contacts of pulmonary TB cases to identify monocyte-specific, Mtb-dependent eQTLs and their association with cytokine expression and clinical resistance to tuberculin skin test (TST) and interferon-γ release assay (IGRA) conversion...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515492/anxiety-and-depression-level-of-patients-with-multidrug-resistant-tuberculosis-mdr-tb-in-two-hospitals-in-banten-province-indonesia
#37
JOURNAL ARTICLE
Tirta Darmawan Susanto, Allen Widysanto, Darien Alfa Cipta, Arron Tanara, Ghivarell Rizkie Wirawan, Adeline Bercadina Kosim, Christabella Maria Djoni, Ervinna Tantri, Chandni Kumar, Chelsie Angelius
PURPOSE: Anxiety and depression can be found in patients diagnosed with multidrug-resistant Tuberculosis (MDR-TB). The purpose of this research is to measure the level of anxiety and depression in new patients with MDR-TB. METHODS: One hundred two new patients newly diagnosed with MDR TB in two hospitals in Banten province, Indonesia, are measured for depression and anxiety symptoms. The measurements used the Indonesian language version of the Zung Anxiety Self-Assessment Scale Questionnaire and the Indonesian version of Zung Self-Rating Depression Scale Questionnaire for Pulmonary Tuberculosis Patients that have been validated...
December 2023: Dialogues Health
https://read.qxmd.com/read/38513873/diagnosis-of-extra-pulmonary-tuberculosis-an-update-on-novel-diagnostic-approaches
#38
REVIEW
Rashi Jain, Gopika Gupta, D K Mitra, Randeep Guleria
Tuberculosis (TB) remains a major global public health problem worldwide. Though Pulmonary TB (PTB) is mostly discussed, one in five cases of TB present are extrapulmonary TB (EPTB) that manifests conspicuous diagnostic and management challenges with respect to the site of infection. The diagnosis of EPTB is often delayed or even missed due to insidious clinical presentation, pauci-bacillary nature of the disease, and lack of laboratory facilities in the resource limited settings. Culture, the classical gold standard for the diagnosis of tuberculosis, suffers from increased technical and logistical constraints in EPTB cases...
March 19, 2024: Respiratory Medicine
https://read.qxmd.com/read/38512356/integrated-plasma-proteomics-identifies-tuberculosis-specific-diagnostic-biomarkers
#39
JOURNAL ARTICLE
Hannah F Schiff, Naomi F Walker, Cesar Ugarte-Gil, Marc Tebruegge, Antigoni Manousopoulou, Spiros D Garbis, Salah Mansour, Pak Ho Wong, Gabrielle Rockett, Paolo Piazza, Mahesan Niranjan, Andres F Vallejo, Christopher H Woelk, Robert J Wilkinson, Liku B Tezera, Diana Garay-Baquero, Paul Elkington
Novel biomarkers to identify infectious patients transmitting Mycobacterium tuberculosis are urgently needed to control the global tuberculosis (TB) pandemic. We hypothesized that proteins released into the plasma in active pulmonary TB are clinically useful biomarkers to distinguish TB cases from healthy individuals and patients with other respiratory infections. We applied a highly sensitive non-depletion tandem mass spectrometry discovery approach to investigate plasma protein expression in pulmonary TB cases compared to healthy controls in South African and Peruvian cohorts...
March 21, 2024: JCI Insight
https://read.qxmd.com/read/38511943/evaluation-of-molecular-diagnostic-test-for-detection-of-adult-pulmonary-tuberculosis-a-generic-protocol
#40
JOURNAL ARTICLE
Madhumathi Jayaprakasam, Ravindra Mohan Pandey, Hansraj Choudhary, Sivakumar Shanmugam, Gomathi N Sivaramakrishnan, Nivedita Gupta
BACKGROUND OBJECTIVES: Tuberculosis (TB) continues to be the second most-leading cause of death due to a single infectious agent as of 2022 after COVID-19. Many affordable new molecular diagnostic tools are being developed for early and more accurate diagnosis, especially for low-resource settings in low- and middle-income countries. In this context, there is a need to develop a standardized protocol for validation of new diagnostic tools. Here, we describe a generic protocol for multi-centric clinical evaluation of molecular diagnostic tests for adult pulmonary TB...
March 20, 2024: Indian Journal of Medical Research
keyword
keyword
37309
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.