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https://www.readbyqxmd.com/read/29141867/host-resistance-to-endotoxic-shock-requires-the-neuroendocrine-regulation-of-group-1-innate-lymphoid-cells
#1
Linda Quatrini, Elisabeth Wieduwild, Sophie Guia, Claire Bernat, Nicolas Glaichenhaus, Eric Vivier, Sophie Ugolini
Upon infection, the immune system produces inflammatory mediators important for pathogen clearance. However, inflammation can also have deleterious effect on the host and is tightly regulated. Immune system-derived cytokines stimulate the hypothalamic-pituitary-adrenal (HPA) axis, triggering endogenous glucocorticoid production. Through interaction with ubiquitously expressed glucocorticoid receptors (GRs), this steroid hormone has pleiotropic effects on many cell types. Using a genetic mouse model in which the gene encoding the GR is selectively deleted in NKp46(+) innate lymphoid cells (ILCs), we demonstrated a major role for the HPA pathway in host resistance to endotoxin-induced septic shock...
November 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29140572/dissecting-human-ilc-heterogeneity-more-than-just-three-subsets
#2
REVIEW
Yannick Simoni, Evan W Newell
Innate lymphoid cells (ILCs) have been divided into three distinct groups based on functional capacities, cytokine profiles and transcription factor expression. Studies done mostly in mice have demonstrated the importance of ILCs in chronic inflammation, infection, allergy and cancer. In this review, we discuss the heterogeneity of human ILC and focus primarily on the taxonomy of human ILC cell subsets and their phenotypic and functional diversity. We summarize recent findings about the diversity of ILCs between and within the major subsets (NK, ILC1, ieILC1, ILC2, ILC3, LTi, ILCP), as well as the abundance of each in human tissues...
November 15, 2017: Immunology
https://www.readbyqxmd.com/read/29138853/role-of-innate-lymphoid-cells-in-obesity-and-metabolic-disease-review
#3
Jirakrit Saetang, Surasak Sangkhathat
The immune system has previously been demonstrated to be associated with the pathophysiological development of metabolic abnormalities. However, the mechanisms linking immunity to metabolic disease remain to be fully elucidated. It has previously been suggested that innate lymphoid cells (ILCs) may be involved in the progression of numerous types of metabolic diseases as these cells act as suppressors and promoters for obesity and associated conditions, and are particularly involved in adipose tissue inflammation, which is a major feature of metabolic imbalance...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137215/-ilc-poiesis-generating-tissue-ilcs-from-na%C3%A3-ve-precursors
#4
EDITORIAL
James P Di Santo, Ai Ing Lim, Hans Yssel
No abstract text is available yet for this article.
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135899/new-oxidative-stress-markers-useful-in-the-diagnosis-of-acute-appendicitis-in-children-thiol-disulfide-homeostasis-and-the-asymmetric-dimethylarginine-level
#5
Bahri Elmas, Turan Yildiz, Hayrullah Yazar, Zekeriya İlçe, Ceylan Bal, Betül Özbek, Yusuf Yürümez
OBJECTIVES: The aim of this study was to evaluate 2 new oxidative stress markers, thiol/disulfide homeostasis status and the asymmetric dimethylarginine (ADMA) level, in children with acute appendicitis (AA) and to evaluate their diagnostic utility. METHODS: This case-control study included 45 patients with AA and 35 healthy children. Age, sex, white blood cell count, neutrophil-to-lymphocyte ratio, high-sensitivity C-reactive protein (hs-CRP) level, ultrasonographic findings, thiol/disulfide homeostasis parameters (native and total thiol levels, native thiol/total thiol ratios [antioxidant parameters], and disulfide, disulfide/native thiol, and disulfide/total thiol ratios [oxidant parameters]), and the ADMA level were compared between the 2 groups...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29135830/tissue-resident-lymphocytes-in-solid-organ-transplantation-innocent-passengers-or-the-key-to-organ-transplant-survival
#6
Amy C Prosser, Axel Kallies, Michaela Lucas
Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same time period, and chronic rejection remains a major cause of graft failure. The importance of donor, or 'passenger', lymphocytes to the induction of tolerance to allografts was recognized in the 1990s; however, their precise contribution to graft acceptance or rejection has not been elucidated. Recently, specialized populations of tissue-resident lymphocytes in nonlymphoid organs have been described...
November 14, 2017: Transplantation
https://www.readbyqxmd.com/read/29132961/title-experimental-asthma-persists-in-il33-receptor-knockout-mice-due-to-the-emergence-of-a-tslp-driven-il9-and-il13-ilc2-subpopulations
#7
Mukesh Verma, Sucai Liu, Lidia Michalec, Anand Sripada, Magdalena M Gorska, Rafeul Alam
BACKGROUND: IL33 plays an important role in development of experimental asthma. OBJECTIVE: To study the role of the IL33 receptor (ST2) in persistence of asthma in a mouse model. METHODS: We studied allergen-induced experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway hyperresponsiveness (AHR) by flexivent, inflammatory indices by ELISA, histology and real-time PCR, and ILC2s in lung single cell preparations by flow cytometry...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132567/lobular-breast-cancer-different-disease-different-algorithms
#8
REVIEW
Anita Mamtani, Tari A King
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer, with a unique pathogenesis and distinct clinical biology. ILCs display a characteristic loss of E-cadherin, are largely estrogen receptor positive, HER2 negative, and low to intermediate grade. These features portend a favorable prognosis, but there is a tendency for late recurrences and atypical metastases. ILCs tend to be insidious and infiltrative, which can pose a challenge for diagnosis, and emerging data suggest they may have a propensity for a differing response to standard therapies...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29123956/mutations-in-jak2-and-calreticulin-genes-are-associated-with-specific-alterations-of-the-immune-system-in-myelofibrosis
#9
Marco Romano, Daria Sollazzo, Sara Trabanelli, Martina Barone, Nicola Polverelli, Margherita Perricone, Dorian Forte, Simona Luatti, Michele Cavo, Nicola Vianelli, Camilla Jandus, Francesca Palandri, Lucia Catani
Myelofibrosis (MF) is a clonal neoplasia associated with chronic inflammation due to aberrant cytokine production. Mutations in Janus Kinase-2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia protein (MPL) genes have been recently associated to MF and they all activate the JAK/STAT signaling pathway. Since this pathway is essential in shaping the immune response, we investigated the role of circulating immune subsets and cytokines in 38 patients (20 carrying JAK2((V617F)),13 exon-9 CALR mutation and 5 triple negative)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29119305/the-development-and-psychometric-properties-of-the-immigration-law-concerns-scale-ilcs-for-hiv-testing
#10
Julia Lechuga, Carol L Galletly, Michelle R Broaddus, Julia B Dickson-Gomez, Laura R Glasman, Timothy L McAuliffe, Miriam Y Vega, Sarah LeGrand, Carla A Mena, Morgan L Barlow, Erik Valera, Judith I Montenegro
To develop, pilot test, and conduct psychometric analyses of an innovative scale measuring the influence of perceived immigration laws on Latino migrants' HIV-testing behavior. The Immigration Law Concerns Scale (ILCS) was developed in three phases: Phase 1 involved a review of law and literature, generation of scale items, consultation with project advisors, and subsequent revision of the scale. Phase 2 involved systematic translation- back translation and consensus-based editorial processes conducted by members of a bilingual and multi-national study team...
November 8, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29117626/unravelling-the-roles-of-innate-lymphoid-cells-in-cerebral-malaria-pathogenesis
#11
J Palomo, Vfj Quesniaux, D Togbe, F Reverchon, B Ryffel
Cerebral malaria (CM) is due to Plasmodium parasite infection leading to inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anemia. Here, we focus on the role of the innate immune response in experimental cerebral malaria (ECM) caused by blood-stage murine Plasmodium berghei ANKA-infection. While T cells are important for ECM pathogenesis, the role of innate lymphoid cells (ILC) is only emerging. The role of ILCs and non-lymphoid cells such as neutrophils and platelets contributing to the host immune response leading to ECM and human cerebral malaria (HCM) is reviewed...
November 8, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29100592/peri-operative-emergency-department-utilization-in-inpatient-and-outpatient-medicare-laparoscopic-cholecystectomy
#12
Susan M Nedza, Donald E Fry, Michael Pine, Agnes M Reband, Pan Chen, Gregory Pine
BACKGROUND: Preoperative emergency department (ED) visits may reflect the patient's biliary disease, or may signal unstable comorbid conditions that have relevance following inpatient laparoscopic cholecystectomy (ILC) and outpatient laparoscopic cholecystectomy (OLC) in Medicare patients. METHODS: We used the Medicare inpatient and outpatient Limited Datasets to identify elective laparoscopic cholecystectomy patients from 2011 to 2014. ED visits for 30-days before the surgical event were identified and correlated with the probability of patients returning to the ED in the 30-days following the procedure...
October 24, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29100072/can-u-turn-ilc2s-up
#13
Paul A Muller, Daniel Mucida
Innate lymphoid cells (ILCs) are tuned to quickly respond to and amplify tissue-specific signals. Work of three independent groups in Nature uncovers a novel mode of inflammatory communication between ILC2s and neurons at mucosal surfaces.
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29093656/functional-defects-in-type-3-innate-lymphoid-cells-and-classical-monocytes-in-a-patient-with-hyper-ige-syndrome
#14
Yuna Chang, Sung-Yoon Kang, Jihyun Kim, Hye-Ryun Kang, Hye Young Kim
Hyper-IgE syndrome (HIES) is a very rare primary immune deficiency characterized by elevated serum IgE levels, recurrent bacterial infections, chronic dermatitis, and connective tissue abnormalities. Autosomal dominant (AD) HIES involves a mutation in signal transducer and activator of transcription 3 (STAT3) that leads to an impaired TH17 response. STAT3 signaling is also involved in the function of RORγt(+) type 3 innate lymphoid cells (ILC3s) and RORγt(+)TH17 cells. The aim of this study was to investigate the role of innate immune cells such as innate lymphoid cells (ILCs), granulocytes, and monocytes in a patient with HIES...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29081776/innate-lymphoid-cells-in-intestinal-inflammation
#15
REVIEW
Alessandra Geremia, Carolina V Arancibia-Cárcamo
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD. ILC are a population of lymphocytes that are enriched at mucosal sites, where they play a protective role against pathogens including extracellular bacteria, helminthes, and viruses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29078283/humanized-mouse-model-supports-development-function-and-tissue-residency-of-human-natural-killer-cells
#16
Dietmar Herndler-Brandstetter, Liang Shan, Yi Yao, Carmen Stecher, Valerie Plajer, Melanie Lietzenmayer, Till Strowig, Marcel R de Zoete, Noah W Palm, Jie Chen, Catherine A Blish, Davor Frleta, Cagan Gurer, Lynn E Macdonald, Andrew J Murphy, George D Yancopoulos, Ruth R Montgomery, Richard A Flavell
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (IL15) and human signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2(-/-) Il2rg(-/-) background (SRG-15)...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29069535/emerging-roles-of-innate-lymphoid-cells-in-inflammatory-diseases-clinical-implications
#17
REVIEW
Inge Kortekaas Krohn, Medya Mara Shikhagaie, Korneliusz Golebski, Jochem H J Bernink, Christine Breynaert, Brecht Creyns, Zuzana Diamant, Wytske J Fokkens, Philippe Gevaert, Peter Hellings, Rudi W Hendriks, Ludger Klimek, Jenny Mjösberg, Hideaki Morita, Graham Ogg, Liam O'Mahony, Jürgen Schwarze, Sven F Seys, Mohamed H Shamji, Suzanne M Bal
Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and non-allergic inflammatory diseases due to their location at barrier surfaces within the airways, gut and skin and they respond to cytokines produced by activated cells in their local environment. ILCs contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity...
October 25, 2017: Allergy
https://www.readbyqxmd.com/read/29068628/upper-limb-rehabilitation-robot-powered-by-pams-cooperates-with-fes-arrays-to-realize-reach-to-grasp-trainings
#18
Xikai Tu, Hualin Han, Jian Huang, Jian Li, Chen Su, Xiaobo Jiang, Jiping He
The reach-to-grasp activities play an important role in our daily lives. The developed RUPERT for stroke patients with high stiffness in arm flexor muscles is a low-cost lightweight portable exoskeleton rehabilitation robot whose joints are unidirectionally actuated by pneumatic artificial muscles (PAMs). In order to expand the useful range of RUPERT especially for patients with flaccid paralysis, functional electrical stimulation (FES) is taken to activate paralyzed arm muscles. As both the exoskeleton robot driven by PAMs and the neuromuscular skeletal system under FES possess the highly nonlinear and time-varying characteristics, iterative learning control (ILC) is studied and is taken to control this newly designed hybrid rehabilitation system for reaching trainings...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065636/iterative-learning-impedance-for-lower-limb-rehabilitation-robot
#19
Chenhui Guo, Shuai Guo, Jiancheng Ji, Fengfeng Xi
This paper discusses the problem of squatting training of stroke patients. The main idea is to correct the patient's training trajectory through an iterative learning control (ILC) method. To obtain better rehabilitation effect, a patient will typically be required to practice a reference posture for many times, while most of active training methods can hardly keep the patients training with correct posture. Instead of the conventional ILC strategy, an impedance-based iterative learning method is proposed to regulate the impedance value dynamically and smartly which will help patients correct their posture gradually and perform better...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065566/upper-limb-rehabilitation-robot-powered-by-pams-cooperates-with-fes-arrays-to-realize-reach-to-grasp-trainings
#20
Xikai Tu, Hualin Han, Jian Huang, Jian Li, Chen Su, Xiaobo Jiang, Jiping He
The reach-to-grasp activities play an important role in our daily lives. The developed RUPERT for stroke patients with high stiffness in arm flexor muscles is a low-cost lightweight portable exoskeleton rehabilitation robot whose joints are unidirectionally actuated by pneumatic artificial muscles (PAMs). In order to expand the useful range of RUPERT especially for patients with flaccid paralysis, functional electrical stimulation (FES) is taken to activate paralyzed arm muscles. As both the exoskeleton robot driven by PAMs and the neuromuscular skeletal system under FES possess the highly nonlinear and time-varying characteristics, iterative learning control (ILC) is studied and is taken to control this newly designed hybrid rehabilitation system for reaching trainings...
2017: Journal of Healthcare Engineering
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