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https://www.readbyqxmd.com/read/28650484/insertional-mutagenesis-identifies-drivers-of-a-novel-oncogenic-pathway-in-invasive-lobular-breast-carcinoma
#1
Sjors M Kas, Julian R de Ruiter, Koen Schipper, Stefano Annunziato, Eva Schut, Sjoerd Klarenbeek, Anne Paulien Drenth, Eline van der Burg, Christiaan Klijn, Jelle J Ten Hoeve, David J Adams, Marco J Koudijs, Jelle Wesseling, Micha Nethe, Lodewyk F A Wessels, Jos Jonkers
Invasive lobular carcinoma (ILC) is the second most common breast cancer subtype and accounts for 8-14% of all cases. Although the majority of human ILCs are characterized by the functional loss of E-cadherin (encoded by CDH1), inactivation of Cdh1 does not predispose mice to develop mammary tumors, implying that mutations in additional genes are required for ILC formation in mice. To identify these genes, we performed an insertional mutagenesis screen using the Sleeping Beauty transposon system in mice with mammary-specific inactivation of Cdh1...
June 26, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28647915/impact-of-the-21-gene-recurrence-score-on-outcome-in-patients-with-invasive-lobular-carcinoma-of-the-breast
#2
Scott Kizy, Jing Li Huang, Schelomo Marmor, Todd M Tuttle, Jane Yuet Ching Hui
PURPOSE: Invasive lobular carcinoma (ILC) of the breast has unique clinicopathologic characteristics, compared to invasive ductal carcinoma. The role of the 21-gene Recurrence Score (RS) has not been clearly defined for ILC. We sought to determine the prognostic value of RS and the impact of adjuvant chemotherapy on long-term survival in patients with ILC. METHODS: Utilizing the Surveillance, Epidemiology and End Results database from 2004 to 2013, we identified records of women aged 18-74 years, diagnosed with estrogen receptor (ER)-positive ILC (stage I to III) with RS available...
June 24, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28630089/dynamic-balance-between-master-transcription-factors-determines-the-fates-and-functions-of-cd4-t-cell-and-innate-lymphoid-cell-subsets
#3
REVIEW
Difeng Fang, Jinfang Zhu
CD4 T cells, including T regulatory cells (Treg cells) and effector T helper cells (Th cells), and recently identified innate lymphoid cells (ILCs) play important roles in host defense and inflammation. Both CD4 T cells and ILCs can be classified into distinct lineages based on their functions and the expression of lineage-specific genes, including those encoding effector cytokines, cell surface markers, and key transcription factors. It was first recognized that each lineage expresses a specific master transcription factor and the expression of these factors is mutually exclusive because of cross-regulation among these factors...
June 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28628772/prognostic-impact-of-proliferation-for-resected-early-stage-pure-invasive-lobular-breast-cancer-cut-off-analysis-of-ki67-according-to-histology-and-clinical-validation
#4
Luisa Carbognin, Isabella Sperduti, Alessandra Fabi, Maria Vittoria Dieci, Dzenete Kadrija, Gaia Griguolo, Sara Pilotto, Valentina Guarneri, Ilaria Zampiva, Matteo Brunelli, Enrico Orvieto, Rolando Nortilli, Elena Fiorio, Veronica Parolin, Erminia Manfrin, Anna Caliò, Cecilia Nisticò, Francesca Pellini, Aldo Scarpa, Giovanni Paolo Pollini, Pierfranco Conte, Giampaolo Tortora, Emilio Bria
INTRODUCTION: The intent of this analysis was to investigate and validate the prognostic potential of Ki67 in a multi-center series of patients affected by early stage 'pure' invasive lobular carcinoma (ILC). METHODS: Clinical-pathological data of patients affected by ILC were correlated with overall survival and disease-free survival (OS/DFS); data from a parallel invasive ductal carcinoma (IDC) patients' cohort were gathered as well. The maximally selected Log-Rank statistics analysis was applied to Ki67 continuous variable to estimate the appropriate cut-off...
June 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28626924/group-2-ilcs-a-way-of-enhancing-immune-protection-against-human-helminths
#5
Norman Nausch, Francisca Mutapi
Group 2 innate lymphoid cells (ILC2s) play crucial roles in type 2 immune responses associated with allergic and autoimmune diseases, viral and helminth infections and tissue homeostasis. Experimental models show that in helminth infections ILC2s provide an early source of type 2 cytokines and therefore are essential for the induction of potentially protective type 2 responses. Much of our knowledge of ILC2s in helminth infections has come from experimental mouse models with very few studies analysing ILC2s in natural human infections...
June 19, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28615725/transcriptome-analysis-reveals-similarities-between-human-blood-cd3-cd56-bright-cells-and-mouse-cd127-innate-lymphoid-cells
#6
David S J Allan, Ana Sofia Cerdeira, Anuisa Ranjan, Christina L Kirkham, Oscar A Aguilar, Miho Tanaka, Richard W Childs, Cynthia E Dunbar, Jack L Strominger, Hernan D Kopcow, James R Carlyle
For many years, human peripheral blood natural killer (NK) cells have been divided into functionally distinct CD3(-) CD56(bright) CD16(-) and CD3(-) CD56(dim) CD16(+) subsets. Recently, several groups of innate lymphoid cells (ILC), distinct from NK cells in development and function, have been defined in mouse. A signature of genes present in mouse ILC except NK cells, defined by Immunological Genome Project studies, is significantly over-represented in human CD56(bright) cells, by gene set enrichment analysis...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613415/composition-and-functionality-of-the-intrahepatic-innate-lymphoid-cell-compartment-in-human-non-fibrotic-and-fibrotic-livers
#7
Marianne Forkel, Lena Berglin, Eliisa Kekäläinen, Adrian Carlsson, Emma Svedin, Jakob Michaëlsson, Maho Nagasawa, Jonas S Erjefält, Michiko Mori, Malin Flodström-Tullberg, Annika Bergquist, Hans-Gustaf Ljunggren, Magnus Westgren, Ulrik Lindforss, Danielle Friberg, Carl Jorns, Ewa Ellis, Niklas K Björkström, Jenny Mjösberg
Human innate lymphoid cells have been described to exist in different organs, with functional deregulation of these cells contributing to several disease states. Here, we performed the first detailed characterization of the phenotype, tissue-residency properties and functionality of ILC1s, ILC2s and ILC3s in the human adult and fetal liver. In addition, we investigated changes in the ILC compartment in liver fibrosis. A unique composition of tissue-resident ILCs was observed in non-fibrotic livers as compared with that in mucosal tissues, with NKp44(-) ILC3s accounting for the majority of total intrahepatic ILCs...
June 14, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28612730/-innate-lymphoid-cells
#8
Adeline Crinier, Charlotte Viant, Mathilde Girard-Madoux, Éric Vivier
Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper-like ILC (ILC1, ILC2, ILC3) which are dependent on T-bet, GATA-3 or RORγT and produce IFN-γ, IL-5/IL-13 or IL-17/IL-22 respectively. Although they were described recently, ILC are the subject of a large number of studies that characterize their role as one of the first effectors of the innate immune response as well as in the development of a wide number of inflammatory disorders...
May 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28612228/pleomorphic-lobular-carcinoma-in-situ-of-the-breast-a-single-institution-experience-with-clinical-follow-up-and-centralized-pathology-review
#9
Marina De Brot, Starr Koslow Mautner, Shirin Muhsen, Victor P Andrade, Anita Mamtani, Melissa Murray, Dilip Giri, Rita A Sakr, Edi Brogi, Tari A King
PURPOSE: The natural history of pleomorphic lobular carcinoma in situ (PLCIS) remains largely unknown. METHODS: A pathology database search (1995-2012) was performed to identify patients diagnosed with an LCIS variant. Patients with synchronous breast cancer and/or no evidence of pleomorphism were excluded. Original slides were re-evaluated by three pathologists to identify a consensus cohort of PLCIS. Borderline lesions with focal atypia were classified as LCIS with pleomorphic features (LCIS-PF)...
June 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28607133/loss-of-thymic-innate-lymphoid-cells-leads-to-impaired-thymopoiesis-in-experimental-graft-vs-host-disease
#10
Jarrod A Dudakov, Anna M Mertelsmann, Margaret H O'Connor, Robert R Jenq, Enrico Velardi, Lauren F Young, Odette M Smith, Richard L Boyd, Marcel R M van den Brink, Alan M Hanash
Graft vs. host disease (GVHD) and post-transplant immunodeficiency are frequently related complications of allogeneic hematopoietic transplantation. Alloreactive donor T cells can damage thymic epithelium, thus limiting new T cell development. While the thymus has a remarkable capacity to regenerate after injury, endogenous thymic regeneration is impaired in GVHD. The mechanisms leading to this regenerative failure are largely unknown. Here we demonstrate in experimental mouse models that GVHD results in depletion of intrathymic group 3 innate lymphoid cells (ILC3s) necessary for thymic regeneration...
June 12, 2017: Blood
https://www.readbyqxmd.com/read/28589939/wash-maintains-nkp46-ilc3-cells-by-promoting-ahr-expression
#11
Pengyan Xia, Jing Liu, Shuo Wang, Buqing Ye, Ying Du, Zhen Xiong, Ze-Guang Han, Liang Tong, Zusen Fan
Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46(+) ILC3s. In NKp46(+) ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46(+) ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46(+) ILC3s...
June 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28589366/meta-analysis-of-pre-operative-magnetic-resonance-imaging-mri-and-surgical-treatment-for-breast-cancer
#12
REVIEW
Nehmat Houssami, Robin M Turner, Monica Morrow
BACKGROUND: Although there is no consensus on whether pre-operative MRI in women with breast cancer (BC) benefits surgical treatment, MRI continues to be used pre-operatively in practice. This meta-analysis examines the association between pre-operative MRI and surgical outcomes in BC. METHODS: A systematic review was performed to identify studies reporting quantitative data on pre-operative MRI and surgical outcomes (without restriction by type of surgery received or type of BC) and using a controlled design...
June 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28586085/enrichment-of-il-17a-ifn-%C3%AE-and-il-22-ifn-%C3%AE-t-cell-subsets-is-associated-with-reduction-of-nkp44-ilc3s-in-the-terminal-ileum-of-crohn-s-disease-patients
#13
Jian Li, Andria L Doty, Ying Tang, Dalton Berrie, Atif Iqbal, Sanda A Tan, Michael J Clare-Salzler, Shannon M Wallet, Sarah C Glover
Crohn's disease (CD) is a chronic inflammatory condition of the human gastrointestinal tract whose etiology remains largely unknown. Dysregulated adaptive immune responses and defective innate immunity both contribute to this process. In this study, we demonstrated that the IL-17A (+) IFN-γ (+) and IL-22 (+) IFN-γ (+) T cell subsets specifically accumulated in the inflamed terminal ileum of CD patients. These cells had higher expression of Ki-67 and were active cytokine producers. In addition, their proportions within both the IL-17A-producer and IL-22-producer populations were significantly increased...
June 6, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28584792/correlation-of-prognostic-factors-of-invasive-lobular-carcinoma-with-adc-value-of-dwi-and-suvmax-of-fdg-pet
#14
Bo Bae Choi, Sung Hun Kim, Chang Suk Park, Na Young Jung
Invasive lobular carcinoma (ILC) is the second most common kind of breast cancer. Diffusion weighted imaging (DWI) and positron emission tomography/computed tomography (PET/CT) are functional modalities for presenting the biological characteristics of breast cancer. The purpose of this article is to study the relationship between DWI or PET/CT and ILC's prognostic factors. The relationship between the apparent diffusion coefficient (ADC) values, standard uptake value (SUV)max and prognostic factors of ILC were statistically evaluated...
May 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28583631/repeated-surgeries-in-invasive-lobular-breast-cancer-with-preoperative-mri-role-of-additional-carcinoma-in-situ-and-background-parenchymal-enhancement
#15
H Preibsch, V Richter, S D Bahrs, V Hattermann, B M Wietek, G Bier, C Kloth, G Blumenstock, M Hahn, A Staebler, K Nikolaou, B Wiesinger
OBJECTIVES: Analysing the influence of additional carcinoma in situ (CIS) and background parenchymal enhancement (BPE) in preoperative MRI on repeated surgeries in patients with invasive lobular carcinoma (ILC) of the breast. METHODS: Retrospective analysis of 106 patients (mean age 58.6±9.9years) with 108 ILC. Preoperative tumour size as assessed by MRI, mammography and sonography was recorded and compared to histopathology. In contrast-enhanced MRI, the degree of BPE was categorised by two readers...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28576981/stat1-represses-cytokine-producing-group-2-and-group-3-innate-lymphoid-cells-during-viral-infection
#16
Matthew T Stier, Kasia Goleniewska, Jacqueline Y Cephus, Dawn C Newcomb, Taylor P Sherrill, Kelli L Boyd, Melissa H Bloodworth, Martin L Moore, Kong Chen, Jay K Kolls, R Stokes Peebles
The appropriate orchestration of different arms of the immune response is critical during viral infection to promote efficient viral clearance while limiting immunopathology. However, the signals and mechanisms that guide this coordination are not fully understood. IFNs are produced at high levels during viral infection and have convergent signaling through STAT1. We hypothesized that STAT1 signaling during viral infection regulates the balance of innate lymphoid cells (ILC), a diverse class of lymphocytes that are poised to respond to environmental insults including viral infections with the potential for both antiviral or immunopathologic functions...
June 2, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28567703/alcohol-intake-and-risk-of-breast-cancer-by-histologic-subtype-and-estrogen-receptor-status-among-women-aged-55-to-74%C3%A2-years
#17
Michelle L Baglia, Kathleen E Malone, Mei-Tzu C Tang, Christopher I Li
Previous studies suggest that alcohol consumption and risk of breast cancer may differ by histologic subtype and hormone receptor status, though results are not entirely consistent. In this population-based case-control study, we evaluated the association between alcohol consumption and risk of invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), and invasive ductal-lobular carcinoma (IDLC) overall and by estrogen receptor (ER) status, among women aged 55-74 years of age. Using polytomous regression, associations between current alcohol consumption, overall and by type of alcohol, and breast cancer risk were evaluated in 891 controls and 905 IDC, 567 ILC, and 489 IDLC cases...
May 31, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28560596/standard-pathologic-features-can-be-used-to-identify-a-subset-of-estrogen-receptor-positive-her2-negative-patients-likely-to-benefit-from-neoadjuvant-chemotherapy
#18
Oriana A Petruolo, Melissa Pilewskie, Sujata Patil, Andrea V Barrio, Michelle Stempel, Hannah Y Wen, Monica Morrow
BACKGROUND: The benefit of neoadjuvant chemotherapy (NAC) in patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancers and in invasive lobular carcinoma (ILC) is uncertain due to the low rates of pathologic complete response (pCR). OBJECTIVE: The aim of this study was to determine if pathologic features can identify subsets likely to benefit from NAC. METHODS: Patients with stage I-III ER+, HER2- breast cancer receiving NAC were retrospectively reviewed...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28559764/factors-affecting-concordance-between-radiological-and-histological-findings-in-invasive-lobular-carcinoma-experience-from-a-national-cancer-centre
#19
Duaa Abu-Sinn, Donal O'Driscoll, Maurice Murphy
BACKGROUND: Invasive lobular carcinoma (ILC) is characterized by an infiltrative discohesive growth pattern, making it difficult to accurately assess both clinically and by imaging studies. Despite favourable biological characteristics, challenges remain in the surgical treatment of ILC. We aimed to evaluate radiology/histology concordance and identify histological and biological parameters on core biopsies that may predict final tumour histology and guide surgical treatment decisions...
May 2017: Breast Care
https://www.readbyqxmd.com/read/28553153/interprofessional-education-development-not-for-the-faint-of-heart
#20
Deborah B Fahs, Linda Honan, Rosana Gonzalez-Colaso, Eve R Colson
Interprofessional education (IPE) has the potential to improve communication, collaboration and coordination of care, leading to improved health care outcomes. Promoting IPE has become an aim for many professional schools. However, there are challenges to implementing meaningful curricula that involve multiple health care professional schools. In this study, we outline 12 lessons learned when designing and implementing an Interprofessional Longitudinal Clinical Experience (ILCE) for 247 students from a School of Nursing, Medicine and Physician Associate Program in New England...
2017: Advances in Medical Education and Practice
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