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https://www.readbyqxmd.com/read/29332938/innate-lymphoid-cells-lipid-surveillance-by-skin-ilcs
#1
Shimona Starling
No abstract text is available yet for this article.
January 15, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29330320/cutting-edge-homeostasis-of-innate-lymphoid-cells-is-imbalanced-in-psoriatic-arthritis
#2
Alina Soare, Stefanie Weber, Lisa Maul, Simon Rauber, Ana Maria Gheorghiu, Markus Luber, Ismail Houssni, Arnd Kleyer, Gero von Pickardt, Manuel Gado, David Simon, Jürgen Rech, Georg Schett, Jörg H W Distler, Andreas Ramming
Innate lymphoid cells (ILC) have a high potency for cytokine production independent of specific Ag stimulation. Imbalance of ILC subsets may influence cytokine production in humans and hence be associated with the development of inflammatory disease. Evidence for an imbalance of ILC homeostasis in human disease, however, is very limited to date. In this study we show that psoriatic arthritis (PsA), a severe disease of the joints depending on the activation of the IL-23/IL-17 pathway, is characterized by a skewed ILC homeostasis...
January 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29318023/microbiome-and-asthma
#3
REVIEW
Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A Akdis, Liam O'Mahony
The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. Dendritic cells, epithelial cells, ILCs, T regulatory cells, effector lymphocytes, NKT cells and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain- or metabolite-specific...
2018: Asthma research and practice
https://www.readbyqxmd.com/read/29317685/flt3-ligand-expands-bona-fide-innate-lymphoid-cell-precursors-in-vivo
#4
Sara M Parigi, Paulo Czarnewski, Srustidhar Das, Christiane Steeg, Leonie Brockmann, Sara Fernandez-Gaitero, Victor Yman, Marianne Forkel, Charlotte Höög, Jenny Mjösberg, Lisa Westerberg, Anna Färnert, Samuel Huber, Thomas Jacobs, Eduardo J Villablanca
A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, their ability to sense cytokines and react to peripheral inflammation remains unaddressed. Here, we found that systemic increase in Flt3L levels correlated with the expansion of Lineage (Lin)negα4β7+ precursors in the adult murine bone marrow. Expanded Linnegα4β7+ precursors were bona fide CHILPs as seen by their ability to differentiate into all helper ILCs subsets but cNK in vivo...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315653/group-1-innate-lymphoid-cells-in-toxoplasma-gondii-infection
#5
Ildiko Rita Dunay, Andreas Diefenbach
Innate lymphoid cells (ILCs) are a group of lymphocytes that carry out important functions in immunity to infections and in organ homeostasis at epithelial barrier surfaces. ILCs are innate immune cells that provide an early source of cytokines to initiate immune responses against pathogens. Cytotoxic ILCs (i.e., conventional (c)NK cells) and several subsets of helper-like ILCs are the major brances of the ILC family. Conventional NK cells and group 1 ILCs share several functions such as surface receptors and the ability to produce IFN-γ upon activation but they differ in their developmental paths and in their dependence on specific transcription factors...
January 9, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29311382/tissue-resident-cytolytic-innate-lymphocytes-in-cancer
#6
REVIEW
Briana G Nixon, Ming O Li
Innate lymphoid cells (ILCs) are critical components of tissues in the body, providing a first line of defense against challenges to host integrity. In contrast to strictly cytokine-producing helper ILCs, resident innate lymphocyte populations with cytolytic potential have been identified in multiple tissues in both mouse and human. These cells express the transcription factor Tbet, NK cell receptors, granzymes, perforin, and death receptors, and can directly kill tumor cells. Signals in the tumor microenvironment may promote this response, including the cytokine IL-15 and stress-associated ligands for activating NK receptors...
January 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29304123/infection-and-depletion-of-cd4-group-1-innate-lymphoid-cells-by-hiv-1-via-type-i-interferon-pathway
#7
Juanjuan Zhao, Liang Cheng, Hongbo Wang, Haisheng Yu, Bo Tu, Qiang Fu, Guangming Li, Qi Wang, Yanling Sun, Xin Zhang, Zhenwen Liu, Weiwei Chen, Liguo Zhang, Lishan Su, Zheng Zhang
Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+ and CD4- subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore, chronic HIV-1 infection activated and depleted both CD4+ and CD4- ILC1s, and impaired their cytokine production activity...
January 5, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29302250/lineage-differentiation-program-of-invariant-natural-killer-t-cells
#8
REVIEW
Dong-Il Kwon, You Jeong Lee
Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages. Promyelocytic leukemia zinc finger (PLZF) modulates this process, and PLZFhigh, PLZFintermediate, and PLZFlow iNKT cells are designated as NKT2, NKT17, and NKT1 cells, respectively. Analogous to conventional helper CD4 T cells, each subset expresses distinct combinations of transcription factors and produces different cytokines...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302015/s1p-dependent-interorgan-trafficking-of-group-2-innate-lymphoid-cells-supports-host-defense
#9
Yuefeng Huang, Kairui Mao, Xi Chen, Ming-An Sun, Takeshi Kawabe, Weizhe Li, Nicholas Usher, Jinfang Zhu, Joseph F Urban, William E Paul, Ronald N Germain
Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have been considered to be tissue-resident cells, but whether ILCs move between tissue sites during infection has been unclear. We show here that interleukin-25- or helminth-induced inflammatory ILC2s are circulating cells that arise from resting ILC2s residing in intestinal lamina propria. They migrate to diverse tissues based on sphingosine 1-phosphate (S1P)-mediated chemotaxis that promotes lymphatic entry, blood circulation, and accumulation in peripheral sites, including the lung, where they contribute to anti-helminth defense and tissue repair...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29296702/a-functional-dc-cross-talk-promotes-human-ilc-homeostasis-in-humanized-mice
#10
Silvia Lopez-Lastra, Guillemette Masse-Ranson, Oriane Fiquet, Sylvie Darche, Nicolas Serafini, Yan Li, Mathilde Dusséaux, Helene Strick-Marchand, James P Di Santo
Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer. Human immune system (HIS) mice develop a broad repertoire of antigen receptor bearing B and T cells that can participate in adaptive immune responses after immunization. In contrast, analysis of innate immune components, including innate lymphoid cells (ILCs) and natural killer (NK) cells, is limited in current HIS mouse models, partly because of the poor development of these rare lymphoid subsets...
April 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296700/il-33-il-25-and-tslp-induce-a-distinct-phenotypic-and-activation-profile-in-human-type-2-innate-lymphoid-cells
#11
Ana Camelo, Guglielmo Rosignoli, Yoichiro Ohne, Ross A Stewart, Catherine Overed-Sayer, Matthew A Sleeman, Richard D May
Innate lymphoid cells (ILCs) represent a distinct branch of the lymphoid lineage composed of 3 major subpopulations: ILC1, ILC2, and ILC3. ILCs are mainly described as tissue-resident cells but can be detected at low levels in human blood. However, unlike mouse ILCs, there is still no consistent methodology to purify and culture these cells that enables in-depth analysis of their intrinsic biology. Here, we describe defined culture conditions for ILC2s, which allowed us to dissect the roles of interleukin 2 (IL-2), IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) individually, or in combination, in modulating ILC2 phenotype and function...
April 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29278421/innate-lymphoid-cells-and-parasites-ancient-foes-with-shared-history
#12
Daniel R Neill, Padraic G Fallon
Innate lymphoid cells (ILCs), lacking antigen receptors but derived from the lymphoid lineage, are recently described new players in immunity that have fundamental roles in immune homeostasis, response to infection, allergy and autoimmunity. Recent years have seen global efforts to unravel the complexities of ILC evolution, lineage commitment and functionality and explore opportunities for manipulation of ILC biology for the treatment of infectious and autoimmune disease. This article is protected by copyright...
December 26, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29261670/human-intrahepatic-ilc2-are-il-13positive-amphiregulinpositive-and-their-frequency-correlates-with-model-of-end-stage-liver-disease-score
#13
Hannah C Jeffery, Patrick McDowell, Philipp Lutz, Rebecca E Wawman, Sheree Roberts, Chris Bagnall, Jane Birtwistle, David H Adams, Ye Htun Oo
INTRODUCTION: Innate lymphoid cells (ILC) have been implicated in the initiation of inflammation and fibrosis in mice. However, ILC have not been characterized in inflamed human liver tissue. METHODS: Human intrahepatic lymphocytes were isolated by mechanical digestion and phenotyped by flow cytometry. Conditioned medium from cultures of primary human biliary epithelial cells, stellate cells, fibroblasts and inflamed human liver tissue was used to model the effects of the inflammatory liver environment of ILC phenotype and function...
2017: PloS One
https://www.readbyqxmd.com/read/29250060/epigenomic-views-of-innate-lymphoid-cells
#14
REVIEW
Giuseppe Sciumè, Han-Yu Shih, Yohei Mikami, John J O'Shea
The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes. Beyond the recognition of specialized effector functionalities in diverse lymphocytes, features typical of T cells, such as plasticity and memory, are also relevant for innate lymphocytes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29244250/human-innate-lymphoid-cells-ilcs-towards-a-uniform-immune-phenotyping
#15
REVIEW
Sara Trabanelli, Alejandra Gomez Cadena, Domenico Mavilio, Basile Nicolas Landis, Peter Jandus, Camilla Jandus
Helper Innate Lymphoid Cells (ILCs), the most recently identified population of the Innate Lymphoid Cell family, plays a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2 and ILC3, that can be specifically activated by different signals coming either from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions...
December 15, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29233542/natural-killer-cells-and-anti-tumor-immunity
#16
Sandra E Nicholson, Narelle Keating, Gabrielle T Belz
Immune checkpoint inhibitors harness the power of the immune system to fight cancer. The clinical success achieved with antibodies against the inhibitory T cell receptors PD-1 and CTLA4 has focused attention on the possibility of manipulating other immune cells, in particular those involved in innate immunity. Here we review the role of innate lymphoid cells (ILCs) and their contribution to tumor immunity. As the prototypical ILC, the natural killer (NK) cell has an intrinsic ability to detect and kill cancer cells...
December 9, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29232860/innate-lymphoid-cells-ilcs-as-mediators-of-inflammation-release-of-cytokines-and-lytic-molecules
#17
REVIEW
Noha Mousaad Elemam, Suad Hannawi, Azzam A Maghazachi
Innate lymphoid cells (ILCs) are an emerging group of immune cells that provide the first line of defense against various pathogens as well as contributing to tissue repair and inflammation. ILCs have been classically divided into three subgroups based on their cytokine secretion and transcription factor profiles. ILC nomenclature is analogous to that of T helper cells. Group 1 ILCs composed of natural killer (NK) cells as well as IFN-γ secreting ILC1s. ILC2s have the capability to produce TH2 cytokines while ILC3s and lymphoid tissue inducer (LTis) are subsets of cells that are able to secrete IL-17 and/or IL-22...
December 10, 2017: Toxins
https://www.readbyqxmd.com/read/29230630/phytochemical-study-and-evaluation-of-cytotoxicity-mutagenicity-cell-cycle-kinetics-and-gene-expression-of-bauhinia-holophylla-bong-steud-in-hepg2-cells-in-vitro
#18
Diego Luis Ribeiro, Heloísa Lizotti Cilião, Ana Flávia Leal Specian, Juliana Mara Serpeloni, Marcelo Tempesta De Oliveira, Eliana Aparecida Varanda, Wagner Vilegas, Luiz Leonardo Saldanha, Wilner Martínez-López, Anne Lígia Dokkedal, Ilce Mara Syllos Cólus
Bauhinia holophylla (Bong.) Steud. (Fabaceae) is a plant used in Brazilian folk medicine to treat diabetes and inflammation. This study evaluated the phytochemical properties, cytotoxic, apoptotic, mutagenic/antimutagenic effects and alterations in gene expression (RNAm) in HepG2 cells treated with the B. holophylla extract. The phytochemical profile highlight the presence of flavonoids isorhamentin and quercetin derivates. The MTT assay was used to evaluate the cytotoxicity of different concentrations for different treatment times...
December 11, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29229782/innate-lymphoid-cells-ilcs-cytokine-hubs-regulating-immunity-and-tissue-homeostasis
#19
Maho Nagasawa, Hergen Spits, Xavier Romero Ros
Innate lymphoid cells (ILCs) have emerged as an expanding family of effector cells particularly enriched in the mucosal barriers. ILCs are promptly activated by stress signals and multiple epithelial- and myeloid-cell-derived cytokines. In response, ILCs rapidly secrete effector cytokines, which allow them to survey and maintain the mucosal integrity. Uncontrolled action of ILCs might contribute to tissue damage, chronic inflammation, metabolic diseases, autoimmunity, and cancer. Here we discuss the recent advances in our understanding of the cytokine network that modulate ILC immune responses: stimulating cytokines, signature cytokines secreted by ILC subsets, autocrine cytokines, and cytokines that induce cell plasticity...
December 11, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29209568/phenotype-and-tissue-distribution-of-cd28h-immune-cell-subsets
#20
Joel Crespo, Linda Vatan, Tomasz Maj, Rebecca Liu, Ilona Kryczek, Weiping Zou
CD28H is a newly discovered co-receptor of the human B7 family. CD28H interacts with its ligand B7-H5 and regulates T cell response. Here we showed that CD28H was not expressed on granulocytes, monocytes, myeloid dendritic cells (MDCs), and B cells, but constitutively expressed with moderate levels on memory T cells and with high levels on naïve T cells, innate lymphoid cells (ILCs), natural killer (NK) cells, and plasmacytoid dendritic cells (PDCs) in human peripheral blood. Similar CD28H+ cell profile existed in secondary lymphoid organs and pathological tissues including multiple types of cancers...
2017: Oncoimmunology
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