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https://www.readbyqxmd.com/read/28203454/mir-328-may-be-considered-as-an-oncogene-in-human-invasive-breast-carcinoma
#1
Alihossein Saberi, Amir Danyaei, Niloofar Neisi, Maryam Dastoorpoor, Mohammad Javad Tahmasbi Birgani
BACKGROUND: The recent investigations have rendered microRNAs (miRs) as a novel biomarker in cancer research. In fact, alteration in miR expression may be associated with tumor suppression, tumorigenesis, metastasis, and poor prognosis in human breast cancer (BC). OBJECTIVES: The aim of this clinical experimental study was to measure the miR-328 expression level in breast cancer tissues, at first. Then, we tried to find out any possible correlation between miR-328 and prognostic and predictive biomarkers in BC...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28191880/single-cell-gene-expression-using-multiplex-rt-qpcr-to-characterize-heterogeneity-of-rare-lymphoid-populations
#2
Thibaut Perchet, Sylvestre Chea, Milena Hasan, Ana Cumano, Rachel Golub
Gene expression heterogeneity is an interesting feature to investigate in lymphoid populations. Gene expression in these cells varies during cell activation, stress, or stimulation. Single-cell multiplex gene expression enables the simultaneous assessment of tens of genes(1)(,)(2)(,)(3). At the single-cell level, multiplex gene expression determines population heterogeneity(4)(,)(5). It allows for the distinction of population heterogeneity by determining both the probable mix of diverse precursor stages among mature cells and also the diversity of cell responses to stimuli...
January 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28188325/correlation-between-tumour-characteristics-suv-measurements-metabolic-tumour-volume-tlg-and-textural-features-assessed-with-18-f-fdg-pet-in-a-large-cohort-of-oestrogen-receptor-positive-breast-cancer-patients
#3
Charles Lemarignier, Antoine Martineau, Luis Teixeira, Laetitia Vercellino, Marc Espié, Pascal Merlet, David Groheux
PURPOSE: The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC). METHODS: 171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an (18)F-FDG PET examination before NAC...
February 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28187931/international-rn-222-in-drinking-water-interlaboratory-comparison
#4
Kevin Kelleher, Jennie Wong, Luis León-Vintró, Lorraine Currivan
A radon in drinking water interlaboratory comparison (ILC) was conducted between eight laboratories in Europe. The majority of the measurement results submitted were in agreement with the assigned value, with a single result deemed questionable. The questionable result does not deviate significantly from the assigned value but the measurement uncertainties associated with this result could be too small. The results from this ILC indicate that there is good agreement between participating laboratories for radon in water measurements...
February 4, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28165478/a-distinct-innate-lymphoid-cell-population-regulates-tumor-associated-t-cells
#5
Sarah Q Crome, Linh T Nguyen, Sandra Lopez-Verges, S Y Cindy Yang, Bernard Martin, Jennifer Y Yam, Dylan J Johnson, Jessica Nie, Michael Pniak, Pei Hua Yen, Anca Milea, Ramlogan Sowamber, Sarah Rachel Katz, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Philipp A Lang, Hal K Berman, Trevor J Pugh, Lewis L Lanier, Pamela S Ohashi
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56(+)CD3(-) population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production...
February 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28154198/il-33-mediated-expansion-of-type-2-innate-lymphoid-cells-protects-from-progressive-glomerulosclerosis
#6
Jan-Hendrik Riedel, Martina Becker, Kerstin Kopp, Mathis Düster, Silke R Brix, Catherine Meyer-Schwesinger, Luis A Kluth, Ann-Christin Gnirck, Madena Attar, Sonja Krohn, Boris Fehse, Rolf A K Stahl, Ulf Panzer, Jan-Eric Turner
Innate lymphoid cells (ILCs) have an important role in the immune system's response to different forms of infectious and noninfectious pathologies. In particular, IL-5- and IL-13-producing type 2 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after injury. However, the presence of renal ILCs in humans has not been reported. In this study, we show that ILC populations are present in the healthy human kidney. A detailed characterization of kidney-residing ILC populations revealed that IL-33 receptor-positive ILC2s are a major ILC subtype in the kidney of humans and mice...
February 2, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28148916/innate-lymphoid-cells-in-autoimmunity-emerging-regulators-in-rheumatic-diseases
#7
REVIEW
Medya M Shikhagaie, Kristine Germar, Suzanne M Bal, Xavier Romero Ros, Hergen Spits
Innate lymphoid cells (ILCs) are important in the regulation of barrier homeostasis. These cells do not express T cell receptors but share many functional similarities with T helper cells and cytotoxic CD8(+) T lymphocytes. ILCs are divided into three groups, namely group 1 ILCs, group 2 ILCs and group 3 ILCs, based on the transcription factors they depend on for their development and function, and the cytokines they produce. Emerging data indicate that ILCs not only have protective functions but can also have detrimental effects when dysregulated, leading to chronic inflammation and autoimmune diseases, including asthma, inflammatory bowel disease, graft-versus-host disease, psoriasis, rheumatoid arthritis and atopic dermatitis...
February 2, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28137365/in-vitro-protective-effects-of-botryosphaeran-a-1%C3%A2-3-1%C3%A2-6-%C3%AE-d-glucan-against-mutagens-in-normal-and-tumor-rodent-cells
#8
Leandra E Kerche-Silva, Ilce M S Cólus, Maressa Malini, Mateus Prates Mori, Robert F H Dekker, Aneli M Barbosa-Dekker
Botryosphaeran (BOT) is an exocellular β-d-glucan (carbohydrate biopolymer) of the (1→3;1→6)-linked type produced by Botryosphaeria rhodina MAMB-05. The cytotoxic, mutagenic, genotoxic, and protective effects of this substance were evaluated in Chinese hamster lung fibroblasts (V79) and rat hepatocarcinoma cells (HTC) by the micronucleus test (MN) and the comet assay. BOT was not genotoxic in either cell line; it decreased the clastogenic effects of doxorubicin, H2O2, and benzo[a]pyrene. These results indicate that BOT may have potential as a therapeutic agent...
February 2017: Mutation Research
https://www.readbyqxmd.com/read/28134248/expression-and-function-of-nkp46-w32r-the-human-homologous-protein-of-mouse-nkp46-w32r-no%C3%A3
#9
Ariella Glasner, Batya Isaacson, Ofer Mandelboim
Natural killer (NK) cells eradicate infected cells and tumors following the triggering of activating receptors, like the Natural Cytotoxicity Receptors (NCRs), which include NKp30, NKp44 and NKp46. NKp46 is the only NCR expressed in mice (mNKp46), and except for some Innate Lymphoid Cell (ILC) populations (ILC1/3 subsets), its expression is restricted to NK cells. Previously, a mouse named Noé was generated in which a random point mutation (W32R) impaired the cell surface expression of mNKp46. Interestingly, the Noé mice NK cells expressed twice as much of the transcription factor Helios, and displayed general non-NKp46 specific hyperactivity...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28124996/expression-of-lipid-metabolism-related-proteins-differs-between-invasive-lobular-carcinoma-and-invasive-ductal-carcinoma
#10
Yoon Jin Cha, Hye Min Kim, Ja Seung Koo
We comparatively investigated the expression and clinical implications of lipid metabolism-related proteins in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast. A total of 584 breast cancers (108 ILC and 476 IDC) were subjected to tissue microarray and immunohistochemical analysis for lipid metabolism-related proteins including hormone-sensitive lipase (HSL), perilipin A, fatty acid binding protein (FABP)4, carnitine palmitoyltransferase (CPT)-1, acyl-CoA oxidase 1, and fatty acid synthetase (FASN)...
January 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28117653/innate-immune-cytokines-fibroblast-phenotypes-and-regulation-of-extracellular-matrix-in-lung
#11
Carl D Richards
Chronic inflammation can be caused by adaptive immune responses in autoimmune and allergic conditions, driven by a T lymphocyte subset balance (TH1, TH2, Th17, Th22, and/or Treg) and skewed cellular profiles in an antigen-specific manner. However, several chronic inflammatory diseases have no clearly defined adaptive immune mechanisms that drive chronicity. These conditions include those that affect the lung such as nonatopic asthma or idiopathic pulmonary fibrosis comprising significant health problems. The remodeling of extracellular matrix (ECM) causes organ dysfunction, and it is largely generated by fibroblasts as the major cell controlling net ECM...
February 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28116477/regulation-and-function-of-mecp2-ser421-phosphorylation-in-u50488-induced-conditioned-place-aversion-in-mice
#12
Anthony S Zannas, Jun H Kim, Anne E West
RATIONALE: Phosphorylation of the methyl DNA-binding protein MeCP2 at Ser421 (pMeCP2-S421) is induced in corticolimbic brain regions during exposure to drugs of abuse and modulates reward-driven behaviors. However, whether pMeCP2-S421 is also involved in behavioral adaptations to aversive drugs is unknown. OBJECTIVES: Our goal was to establish the role and regulation of pMeCP2-S421 in corticolimbic brain regions of mice upon acute treatment with the kappa opioid receptor agonist U50488 and during the expression of U50488-induced conditioned place aversion (CPA)...
January 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28115527/cutting-edge-notch-signaling-promotes-the-plasticity-of-group-2-innate-lymphoid-cells
#13
Kangning Zhang, Xingyuan Xu, Muhammad Asghar Pasha, Christian W Siebel, Angelica Costello, Angela Haczku, Katherine MacNamara, Tingbo Liang, Jinfang Zhu, Avinash Bhandoola, Ivan Maillard, Qi Yang
The mechanisms underlying lymphocyte lineage stability and plasticity remain elusive. Recent work indicates that innate lymphoid cells (ILC) possess substantial plasticity. Whereas natural ILC2 (nILC2) produce type-2 cytokines, plastic inflammatory ILC2 (iILC2) can coproduce both type-2 cytokines and the ILC3-characteristic cytokine, IL-17. Mechanisms that elicit this lineage plasticity, and the importance in health and disease, remain unclear. In this study we show that iILC2 are potent inducers of airway inflammation in response to acute house dust mite challenge...
January 23, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28111737/expression-of-dna-methylation-related-proteins-in-invasive-lobular-carcinoma-of-breast-comparison-to-invasive-ductal-carcinoma
#14
Yoon Jin Cha, Hye Min Kim, Ja Seung Koo
PURPOSE: We aimed to compare the expression of DNA methylation-related proteins in invasive lobular carcinoma (ILC) of breast with those of invasive ductal carcinoma (IDC) of breast and to assess its potential clinical application. METHODS: Immunohistochemical staining of DNS methylation-related proteins (5-meC, DNMT1, DNMT3B and ISL-1) was applied to tissue microarrays generated from 108 ILCs and 203 IDCs. Protein expression and its correlation with clinicopatholgic variables were statistically analyzed...
January 23, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28109886/truncated-prion-protein-prp226-a-structural-view-on-its-role-in-amyloid-disease
#15
Valerija Kovač, Blaž Zupančič, Gregor Ilc, Janez Plavec, Vladka Čurin Šerbec
In the brain of patients with transmissible spongiform encephalopathies, besides PrP(Sc) aggregates, deposition of truncated PrP molecules was described. Jansen et al. reported two clinical cases with deposition of C-terminally truncated PrP, one of them ending with Tyr226. We have previously described the discovery of monoclonal antibody V5B2 that selectively recognizes this version of the prion protein, which we called PrP226*. Using monoclonal antibody V5B2 we showed that accumulation of PrP226* is characteristic for most types of human and animal TSEs...
January 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28108967/specific-sites-of-metastases-in-invasive-lobular-carcinoma-a-retrospective-cohort-study-of-metastatic-breast-cancer
#16
Masayuki Inoue, Hiroshi Nakagomi, Haruka Nakada, Kazushige Furuya, Kou Ikegame, Hideki Watanabe, Masao Omata, Toshio Oyama
BACKGROUND: Invasive lobular carcinoma (ILC) is known to be the second most common histological type following invasive ductal carcinoma (IDC). Definitive clinical features of ILC are controversial. METHODS: We retrospectively analyzed a cohort of 330 patients with metastatic breast cancer, 303 of IDC, 19 of ILC, and 8 of others. We compared the patient age and tumor-node-metastasis factors, disease-free survival (DFS), estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression at the primary site between ILC and IDC...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28108952/transcriptional-regulators-dictate-innate-lymphoid-cell-fates
#17
REVIEW
Chao Zhong, Jinfang Zhu
Research on innate lymphoid cells (ILC) has recently been a fast paced topic of immunological research. As ILCs are able to produce signature Th cytokine, ILCs have garnered considerable attention and have been described to represent the innate counterpart of the CD4(+) T helper (Th) cells. The development and function of ILCs are precisely regulated by a network of crucial transcription factors, which are also involved in the development or differentiation of conventional natural killer (cNK) cells and T cells...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28103115/involvement-of-autophagy-in-nk-cell-development-and-function
#18
Alejandro López-Soto, José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi, Segundo Gonzalez
Natural killer (NK) cells are the prototypical members of the recently identified family of innate lymphoid cells (ILCs). Thanks to their cytotoxic and secretory functions, NK cells play a key role in the immune response to cells experiencing various forms of stress, including viral infection and malignant transformation. Autophagy is a highly conserved network of degradative pathways that participate in the maintenance of cellular and organismal homeostasis as they promote adaptation to adverse microenvironmental conditions...
January 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28099859/how-many-subsets-of-innate-lymphoid-cells-do-we-need
#19
Kafi N Ealey, Shigeo Koyasu
Innate lymphoid cells (ILCs) are composed of three main subsets. In this issue of Immunity, Simoni et al. (2017) show using mass-cytometry that human ILCs are highly heterogeneous between individuals and tissues and lack a previously proposed helper-type ILC1 population.
January 17, 2017: Immunity
https://www.readbyqxmd.com/read/28098786/retinoic-acid-and-its-role-in-modulating-intestinal-innate-immunity
#20
REVIEW
Paulo Czarnewski, Srustidhar Das, Sara M Parigi, Eduardo J Villablanca
Vitamin A (VA) is amongst the most well characterized food-derived nutrients with diverse immune modulatory roles. Deficiency in dietary VA has not only been associated with immune dysfunctions in the gut, but also with several systemic immune disorders. In particular, VA metabolite all-trans retinoic acid (atRA) has been shown to be crucial in inducing gut tropism in lymphocytes and modulating T helper differentiation. In addition to the widely recognized role in adaptive immunity, increasing evidence identifies atRA as an important modulator of innate immune cells, such as tolerogenic dendritic cells (DCs) and innate lymphoid cells (ILCs)...
January 13, 2017: Nutrients
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