keyword
MENU ▼
Read by QxMD icon Read
search

ilc

keyword
https://www.readbyqxmd.com/read/29782555/langerin-dcs-regulate-innate-il-17-production-in-the-oral-mucosa-during-candida-albicans-mediated-infection
#1
Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immunity against OPC, the cellular source and the regulation of this cytokine during infection are still a matter of debate. Here, we directly visualized IL-17 production in the infected tongue of experimentally infected mice, thereby demonstrating that this key cytokine is expressed by three complementary subsets of CD90+ leukocytes: RAG-dependent αβ and γδ T cells, as well as RAG-independent ILCs...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29774524/%C3%AE-e-catenin-is-a-candidate-tumor-suppressor-for-the-development-of-e-cadherin-expressing-lobular-type-breast-cancer
#2
Jolien S de Groot, Max A K Rätze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick W B Derksen
Mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), although approximately 10-15% of all ILCs retain membrane-localized E-cadherin, despite the presence of an apparent non-cohesive and invasive lobular growth pattern. Given that ILC is dependent on constitutive actomyosin contraction for tumor development and progression, we used a combination of cell systems and in vivo experiments to investigate the consequences of α-catenin (CTNNA1) loss in the regulation of anchorage independence of non-invasive breast carcinoma...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29774321/sentinel-lymph-node-metastasis-in-invasive-lobular-carcinoma-of-the-breast
#3
Hikmet Erhan Güven, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
Objective: Invasive lobular carcinoma (ILC) of the breast makes up 5 to 15 percent of all invasive breast cancers. It has distinctive clinical and histopathological features when compared to invasive ductal carcinoma (IDC). This study intends to describe factors influencing sentinel lymph node (SLN) positivity in patients with "pure" ILC. Materials and Methods: Data of 105 patients, who were treated at a tertiary oncology center, with lobular carcinoma of the breast that were subjected to SLN biopsy was probed retrospectively...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29770140/seventeen-year-journey-working-with-a-master
#4
Jinfang Zhu
It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field. Under his outstanding guidance, my research has been focusing on transcriptional regulation of T helper (Th) cell differentiation, especially, on the role of a master transcription factor GATA3 during Th2 cell differentiation. Just as enormous scientific contributions of Dr. Paul (we all call him Bill) to the immunology community are far beyond his serving as the Chief of the LI, GATA3 also plays important roles in different lymphocytes at various developmental stages besides its critical functions in Th2 cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760540/ambiguous-roles-of-innate-lymphoid-cells-in-chronic-development-of-liver-diseases
#5
REVIEW
Yue Shen, Jing Li, Si-Qi Wang, Wei Jiang
Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs (ILC2s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin (IL)-5 and IL-13; and, group 3 ILCs (including lymphoid tissue-like cells and ILC3s) are dependent on RORγt and can produce IL-22 and IL-17...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29759595/her2-positive-lobular-versus-ductal-carcinoma-of-the-breast-pattern-of-first-recurrence-and-molecular-insights
#6
Lucia Da Ros, Anna Moretti, Patrizia Querzoli, Massimo Pedriali, Laura Lupini, Cristian Bassi, Paolo Carcoforo, Massimo Negrini, Antonio Frassoldati
BACKGROUND: Infiltrating lobular carcinoma (ILC) represents about 10% of breast cancer and rarely shows overexpression of human epidermal growth factor receptor 2 (HER2). We compared biological and clinical characteristics of HER2-positive ILC versus HER2-positive infiltrating ductal carcinoma (IDC). PATIENTS AND METHODS: We retrospectively analyzed the data of 328 patients with HER2-positive pure ductal or lobular breast carcinoma, comparing clinical and biological data at diagnosis as well as outcome between the 2 histologies...
April 18, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29754579/peer-relationships-and-quality-of-life-in-11-12-year-old-children-the-health-oriented-pedagogical-project-hopp
#7
Natalia Lezhnieva, Per Morten Fredriksen, Mona Bekkhus
AIMS: Social interactions play an important role in our everyday life. Studies on children's quality of life (QoL) show that peer relations are associated with both positive and negative outcomes. Popularity defines the degree to which a child is liked by his or her peers, whereas reciprocal friendship occurs when two children mutually nominate each other as friends. The overall aim was to examine associations between peer relations and children's QoL. METHODS: Baseline data were from the Health Oriented Pedagogical Project (HOPP)...
May 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29754578/quality-of-life-in-primary-school-children-the-health-oriented-pedagogical-project-hopp
#8
Kristen Ringdal, Gerd Inger Ringdal, Helene Kristin Olsen, Asgeir Mamen, Per Morten Fredriksen
AIMS: The primary aim of the present study was to evaluate the association between parents' level of education, measurements of physical attributes, and quality of life in a general sample of primary school children. METHODS: The children's and the parents' versions of the Inventory of Life Quality in Children and Adolescents (ILC) were used to measure health-related quality of life (QOL) in 2140 school children (response rate 93%) and 1639 parents (response rate 71%) recruited from nine primary schools in Norway...
May 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29752828/cannabis-smoking-impairs-driving-performance-on-simulator-and-real-driving-a-randomized-double-blind-placebo-controlled-crossover-trial
#9
Joëlle Micallef, Julien Dupouey, Elisabeth Jouve, Romain Truillet, Bruno Lacarelle, Jack Taillard, Agnès Daurat, Colas Authié, Olivier Blin, Olivier Rascol, Pierre Philip, Daniel Mestre
Driving experiments in real conditions are considered as a "gold standard" to evaluate the effects of drugs on driving performance. Several constraints are difficult to manage in these conditions, so driving simulation appears as the best alternative. A preliminary comparison is crucial before being able to use driving simulation as a valid evaluation method. The aim of this study was to design a driving simulation method for assessing drugs effects on driving. We used cannabis (THC) as a positive control and assessed whether THC affects driving performance in simulation conditions and whether these effects are consistent with performance in real driving conditions...
May 12, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29746218/effect-of-an-innovative-technology-active-warming-and-passive-warming-on-unplanned-hypothermia-during-perioperative-period-a-clinical-trial
#10
Ganime Esra Soysal, Arzu İlçe, Mehmet Hayri Erkol
Patients are at risk for unplanned hypothermia during the perioperative period due to many reasons, including anesthesia, low room temperature, cold intravenous fluid, and blood transfusion. This study was conducted to examine the effect of active and passive warming methods applied in patients during the perioperative period on unplanned hypothermia. This study is a case-control type study. The population of this study is composed of the patients hospitalized in surgical clinic and undergone abdominal region-related operations...
May 10, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29744328/bilateral-metachronous-breast-carcinoma-a-rare-case-report
#11
Anand Singla, Navneet Kaur, Darshanjeet Singh Walia, Deeksha Singla
The occurrence of bilateral breast cancer is rare. A second primary in the contralateral breast can either be synchronous or metachronous. Lobular carcinoma of the breast is known for its multicentricity and bilateral spread. The synchronous mixed pattern of carcinoma of the breast has also been reported in the same breast. The family history of breast carcinoma, estrogen receptor negativity, and human epidermal growth factor receptor-2 positivity are risk factors for the development of contralateral breast malignancy...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29739984/invasive-lobular-and-ductal-breast-carcinoma-differ-in-immune-response-protein-translation-efficiency-and-metabolism
#12
Tian Du, Li Zhu, Kevin M Levine, Nilgun Tasdemir, Adrian V Lee, Dario A A Vignali, Bennett Van Houten, George C Tseng, Steffi Oesterreich
Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer following invasive ductal carcinoma (IDC). ILC differs from IDC in a number of histological and clinical features, such as single strand growth, difficulty in detection, and frequent late recurrences. To understand the molecular pathways involved in the clinical characteristics of ILC, we compared the gene expression profiles of luminal A ILC and luminal A IDC using data from TCGA and utilized samples from METABRIC as a validation data set...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29730679/impact-of-strain-elastography-on-bi-rads-classification-in-small-invasive-lobular-carcinoma
#13
Angelica Rita Chiorean, Mădălina Brîndușa Szep, Diana Sorina Feier, Magdalena Duma, Marco Andrei Chiorean, Ștefan Strilciuc
AIMS: The purpose of this study was to determine the impact of strain elastography (SE) on the Breast Imaging Reporting Data System (BI-RADS) classification depending on invasive lobular carcinoma (ILC) lesion size. MATERIALS AND METHODS: We performed a retrospective analysis on a sample of 152 female subjects examined between January 2010 - January 2017. SE was performed on all patients and ILC was subsequently diagnosed by surgical or ultrasound-guided biopsy...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29730548/the-determination-of-ethyl-glucuronide-in-hair-experiences-from-nine-consecutive-interlaboratory-comparison-rounds
#14
R Becker, I Lô, F Sporkert, M Baumgartner
The increasing request for hair ethyl glucuronide (HEtG) in alcohol consumption monitoring according to cut-off levels set by the Society of Hair Testing (SoHT) has triggered a proficiency testing program based on interlaboratory comparisons (ILC). Here, the outcome of nine consecutive ILC rounds organised by the SoHT on the determination of HEtG between 2011 and 2017 is summarised regarding interlaboratory reproducibility and the influence of procedural variants. Test samples prepared from cut hair (1mm) with authentic (in-vivo incorporated) and soaked (in-vitro incorporated) HEtG concentrations up to 80pg/mg were provided for 27-35 participating laboratories...
April 26, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29728440/peripheral-pdgfr%C3%AE-gp38-mesenchymal-cells-support-the-differentiation-of-fetal-liver-derived-ilc2
#15
Satoshi Koga, Katsuto Hozumi, Ken-Ichi Hirano, Masaki Yazawa, Tommy Terooatea, Aki Minoda, Takashi Nagasawa, Shigeo Koyasu, Kazuyo Moro
Group 2 innate lymphoid cells (ILC2s) are derived from common lymphoid progenitors (CLPs) via several specific precursors, and the transcription factors essential for ILC2 differentiation have been extensively studied. However, the external factors regulating commitment to the ILC lineage as well as the sites and stromal cells that constitute the optimal microenvironment for ILC2-specific differentiation are not fully defined. In this study, we demonstrate that three key external factors, the concentration of interleukin 7 (IL-7) and strength and duration of Notch signaling, coordinately determine the fate of CLP toward the T, B, or ILC lineage...
May 4, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29728401/immune-regulatory-cell-infusion-for-graft-versus-host-disease-prevention-and-therapy
#16
Bruce R Blazar, Kelli P A MacDonald, Geoffrey R Hill
Current approaches to prevent and treat graft-versus-host disease (GVHD) after stem cell transplantation rely principally on pharmacological immune suppression. Such approaches are limited by drug toxicity, non-specific immune suppression and a requirement for long-term therapy. Our increased understanding of the regulatory cells and molecular pathways involved in limiting pathogenic immune responses opens the opportunity for the use of these cell subsets to prevent and/or GVHD. The theoretical advantages of this approach is permanency of effect, potential for facilitating tissue repair, and induction of tolerance that obviates a need for ongoing drug therapy...
May 4, 2018: Blood
https://www.readbyqxmd.com/read/29726984/immune-cell-census-in-murine-atherosclerosis-cytometry-by-time-of-flight-illuminates-vascular-myeloid-cell-diversity
#17
Jennifer E Cole, Inhye Park, David Ahern, Christina Kassiteridi, Dina Danso Abeam, Michael Goddard, Patricia Green, Pasquale Maffia, Claudia Monaco
Aims: Atherosclerosis is characterised by the abundant infiltration of myeloid cells starting at early stages of disease. Myeloid cells are key players in vascular immunity during atherogenesis. However, the subsets of vascular myeloid cells have eluded resolution due to shared marker expression and atypical heterogeneity in vascular tissues. We applied the high-dimensionality of mass cytometry to the study of myeloid cell subsets in atherosclerosis. Methods and Results: Apolipoprotein E-deficient (ApoE-/-) mice were fed a chow or a high fat (western) diet for 12 weeks...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29720597/-19-f-nmr-studies-provide-insights-into-lipid-membrane-interactions-of-listeriolysin-o-a-pore-forming-toxin-from-listeria-monocytogenes
#18
Mirijam Kozorog, Marc-Antoine Sani, Martina Lenarčič Živković, Gregor Ilc, Vesna Hodnik, Frances Separovic, Janez Plavec, Gregor Anderluh
Listeria monocytogenes is a mammalian pathogen that causes gastroenteritis, miscarriages and infections of the central nervous system in immunocompromised individuals. Its main virulence factor is listeriolysin O (LLO), a pore-forming cholesterol-dependent cytolysin (CDC), which enables bacterial escape from the phagolysosome and contributes to bacterial pathogenicity. Details of cholesterol (Chol) recognition and membrane binding mechanisms by LLO are still not known. Here we used 19 F-NMR spectroscopy in order to assess LLO-Chol interactions in solution and in a Chol-rich membrane environment...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703840/transcription-factor-id2-prevents-e-proteins-from-enforcing-a-na%C3%A3-ve-t-lymphocyte-gene-program-during-nk-cell-development
#19
Erin C Zook, Zhong-Yin Li, Yiying Xu, Renée F de Pooter, Mihalis Verykokakis, Aimee Beaulieu, Anna Lasorella, Mark Maienschein-Cline, Joseph C Sun, Mikael Sigvardsson, Barbara L Kee
All innate lymphoid cells (ILCs) require the small helix-loop-helix transcription factor ID2, but the functions of ID2 are not well understood in these cells. We show that mature natural killer (NK) cells, the prototypic ILCs, developed in mice lacking ID2 but remained as precursor CD27+ CD11b- cells that failed to differentiate into CD27- CD11b+ cytotoxic effectors. We show that ID2 limited chromatin accessibility at E protein binding sites near naïve T lymphocyte-associated genes including multiple chemokine receptors, cytokine receptors, and signaling molecules and altered the NK cell response to inflammatory cytokines...
April 27, 2018: Science Immunology
https://www.readbyqxmd.com/read/29702643/dependence-of-innate-lymphoid-cell-1-development-on-nkp46
#20
Yufeng Wang, Wenjuan Dong, Yibo Zhang, Michael A Caligiuri, Jianhua Yu
NKp46, a natural killer (NK) cell-activating receptor, is involved in NK cell cytotoxicity against virus-infected cells or tumor cells. However, the role of NKp46 in other NKp46+ non-NK innate lymphoid cell (ILC) populations has not yet been characterized. Here, an NKp46 deficiency model of natural cytotoxicity receptor 1 (Ncr1)gfp/gfp and Ncr1gfp/+ mice, i.e., homozygous and heterozygous knockout (KO), was used to explore the role of NKp46 in regulating the development of the NKp46+ ILCs. Surprisingly, our studies demonstrated that homozygous NKp46 deficiency resulted in a nearly complete depletion of the ILC1 subset (ILC1) of group 1 ILCs, and heterozygote KO decreased the number of cells in the ILC1 subset...
April 2018: PLoS Biology
keyword
keyword
37308
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"