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JOURNAL ARTICLE
Mafalda F Teixeira, Mónica Lopes, Frederico Batista, Ana Bastos Furtado, José Delgado Alves
BACKGROUND: Noninvasive mechanical ventilation (NIMV) has been established as a successful therapeutic option for patients with acute respiratory failure (ARF) with a specific etiology. OBJECTIVES: This study evaluated the morbimortality of patients with ARF treated with NIMV in a medical intermediate care unit (UCINT) to identify factors associated with higher in-hospital mortality, six-month mortality, and three- and six-month hospital readmission rates. METHODS: This retrospective cohort study included elderly patients admitted for ARF and treated with NIMV in the UCINT between 2015 and 2019...
November 2022: Curēus
#22
JOURNAL ARTICLE
Ayse Bahadir, Sinem Iliaz, Mehmet Hursitoglu, Gul Unalan, Sibel Yurt, Mehmet Akif Ozgul
It is known that pneumothorax (PX) and pneumomediastinum (PM) develop due to COVID-19 disease. The objective of our study was to determine the prevalence of PX/PM due to COVID-19 in the intermediate intensive care unit (IMCU) and to evaluate the factors causing barotrauma and also the clinical outcomes of these patients. A total of 283 non-intubated patients with COVID-19 pneumonia followed up in the IMCU in a 1-year period were included in the study. The patients were classified as group 1 (having barotrauma) and group 2 (without barotrauma)...
November 7, 2022: Journal of Personalized Medicine
#23
JOURNAL ARTICLE
Kai Kang, Junfeng Wang, Xue Du, Nana Li, Songgen Jin, Yuanyuan Ji, Xinjia Liu, Pengfei Chen, Chuangshi Yue, Jihan Wu, Xintong Wang, Yujia Tang, Qiqi Lai, Baitao Lu, Yang Gao, Kaijiang Yu
IMPORTANCE: The number of infections and deaths caused by the global epidemic of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) invasion is steadily increasing daily. In the early stages of outbreak, approximately 15%-20% of patients with coronavirus disease 2019 (COVID-19) inevitably developed severe and critically ill forms of the disease, especially elderly patients and those with several or serious comorbidities. These more severe forms of disease mainly manifest as dyspnea, reduced blood oxygen saturation, severe pneumonia, acute respiratory distress syndrome (ARDS), thus requiring prolonged advanced respiratory support, including high-flow nasal cannula (HFNC), non-invasive mechanical ventilation (NIMV), and invasive mechanical ventilation (IMV)...
2022: Frontiers in Surgery
#24
RANDOMIZED CONTROLLED TRIAL
Neven Sarhan, Ahmed E Abou Warda, Rania M Sarhan, Marian S Boshra, Gomaa Mostafa-Hedeab, Bashayer F ALruwaili, Haytham Soliman Ghareeb Ibrahim, Mona F Schaalan, Shaimaa Fathy
Background and Objectives: Vitamin D supplementation plays a key effect in lowering cytokine storms among COVID-19 patients by influencing the activity of the renin-angiotensin system and the production of the angiotensin-2 converting enzyme. The study was conducted to explore the effect of high-dose intramuscular vitamin D in hospitalized adults infected with moderate-to-severe SARS-CoV-2 in comparison with the standard of care in the COVID-19 protocol. Materials and Methods: Two groups of patients were compared in this prospective randomized controlled trial as the vitamin D was administered orally to group 1 (alfacalcidol 1 mcg/day) and intramuscularly to group 2 (cholecalciferol 200,000 IU)...
September 27, 2022: Medicina
#25
JOURNAL ARTICLE
Crhistian-Mario Oblitas, Francisco Galeano-Valle, Carmen Cuenca-Carvajal, Sandra Piqueras-Ruiz, Rubén Alonso-Beato, Álvaro Alejandre-de-Oña, Paula Carrascosa-Fernández, Agustín-Diego Chacón Moreno, Alejandro Parra-Virto, María-Teresa Pérez Sanz, Laura Abarca Casas, Clara Millán-Nohales, Luis Álvarez-Sala-Walther, Pablo Demelo-Rodríguez
BACKGROUND: The real predictive prognostic capacity of cellular indices (or ratios) is unclear in SARS-CoV-2 infection. This study aimed to assess the prognostic role of previously well-known laboratory indices and new ones in hospitalized COVID-19 patients. METHODS: A retrospective observational study from March to May 2022 evaluated laboratory indices on admission (neutrophil to lymphocyte-, derived neutrophil to lymphocyte-, platelet to lymphocyte-, CRP to lymphocyte-, CRP to albumin-, fibrinogen to lymphocyte-, d-dimer to lymphocyte-, ferritin to lymphocyte-, LDH to lymphocyte-, and IL-6 to lymphocyte ratios), in patients hospitalized due to SARS-CoV2 infection to determine the association with mortality, admission to an intensive care unit (ICU), need for non-invasive mechanical ventilation (NIMV), orotracheal intubation (OTI), or combined event at 30 days follow-up...
December 2022: Infectious Diseases
#26
JOURNAL ARTICLE
Carolina A Isnardi, Karen Roberts, Verónica Saurit, Ingrid Petkovic, Roberto M Báez, Rosana Quintana, Yohana Tissera, Sofía Ornella, Maria Eugenia D Angelo Exeni, Cecilia N Pisoni, Vanessa V Castro Coello, Guillermo Berbotto, María J Haye Salinas, Edson Velozo, Álvaro A Reyes Torres, Romina Tanten, Marcos D Zelaya, Carla Gobbi, Carla G Alonso, María de Los Ángeles Severina, Florencia Vivero, Alba Paula, Adriana K Cogo, Gelsomina Alle, Mariana Pera, Romina E Nieto, Micaela Cosatti, Cecilia Asnal, Dora Pereira, Juan A Albiero, Verónica G Savio, Federico N Maldonado, María Julieta Gamba, Noelia F Germán, Andrea Baños, Josefina Gallino Yanzi, María Soledad Gálvez Elkin, Julieta S Morbiducci, María Victoria Martire, Hernán Maldonado Ficco, Maria Marcela Schmid, Jaime A Villafañe Torres, Maria de Los Ángeles Correa, María Alejandra Medina, María Alejandra Cusa, Julia Scafati, Santiago E Agüero, Nicolás M Lloves Schenone, Enrique R Soriano, Cesar Graf, Bernardo A Pons-Estel, Gimena Gomez, Margarita Landi, María Celina De la Vega, Guillermo J Pons-Estel
BACKGROUND/OBJECTIVE: This study aims to describe the course and to identify poor prognostic factors of SARS-CoV-2 infection in patients with rheumatic diseases. METHODS: Patients ≥ 18 years of age, with a rheumatic disease, who had confirmed SARS-CoV-2 infection were consecutively included by major rheumatology centers from Argentina, in the national, observational SAR-COVID registry between August 13, 2020 and July 31, 2021. Hospitalization, oxygen requirement, and death were considered poor COVID-19 outcomes...
October 6, 2022: Clinical Rheumatology
#27
JOURNAL ARTICLE
Nur Berna Celik, Murat Tanyildiz, Filiz Yetimakman, Selman Kesici, Benan Bayrakci
Post-extubation respiratory failure is associated with a poor prognosis due to increased ventilator-associated pneumonia, and longer length of stay in the ICU and hospital. In this study, we aimed to evaluate the efficacy of high-flow nasal cannula (HFNC) and noninvasive mechanical ventilation (NIMV) on extubation success in children. A total of 48 patients, aged between 1 month and 18 years, who were weaned to either NIMV or HFNC were included. Patients who had tracheostomy or were not weaned and underwent unplanned extubation were excluded...
September 30, 2022: Medicine (Baltimore)
#28
JOURNAL ARTICLE
Xuejuan Zhu, Xiaofan Wang, Xing Jin, Yonghua Sang, Wentao Yang, Yongbing Chen, Shanzhou Duan
BACKGROUND: Patients who underwent lobectomy resection are prone to hypoxemia, and the vast majority present with type I respiratory failure. Thus, improvement of hypoxemia is one of the most important factors to facilitate postoperative recovery of patients. In this study, the superiority-inferiority of different oxygen inhalation methods were compared with high-flow nasal oxygen therapy (HFNO), noninvasive mechanical ventilation (NIMV) and nasal oxygen breath (NOB) in patients with hypoxemia after single-port video-assisted thoracoscopic (VATS) lobectomy, and the clinical efficacy of HFNO in these patients was further investigated...
September 20, 2022: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
#29
REVIEW
Woon Hean Chong, Biplab K Saha, Chee Keat Tan
Before coronavirus disease 2019 (COVID-19) emerged, proning had been demonstrated to improve oxygenation in those with acute hypoxic respiratory failure and be performed in non-intensive care settings. This benefit was further exemplified by the COVID-19 pandemic, leading to awake prone positioning (APP). We assessed the efficacy of routine APP versus standard care in preventing death and invasive mechanical ventilation (IMV) in non-intubated hypoxic COVID-19 patients. PubMed, Cochrane Library, Scopus, and medRxiv databases were used from January 1st, 2020, to January 15th, 2022, to identify randomized controlled trials (RCTs)...
2022: Prague Medical Report
#30
JOURNAL ARTICLE
Mihailo I Stjepanovic, Maja R Stojanovic, Sanja Stankovic, Jelena Cvejic, Sanja Dimic-Janjic, Spasoje Popevic, Ivana Buha, Slobodan Belic, Natasa Djurdjevic, Mirjana M Stjepanovic, Dragana Jovanovic, Milica Stojkovic-Laloševic, Ivan Soldatovic, Branka Bonaci-Nikolic, Rada Miskovic
Background: Immune dysregulation and associated inefficient anti-viral immunity during Coronavirus Disease 2019 (COVID-19) can cause tissue and organ damage which shares many similarities with pathogenetic processes in systemic autoimmune diseases. In this study, we investigate wide range autoimmune and immunoserological markers in hospitalized patients with COVID-19. Methods: Study included 51 patients with confirmed Severe Acute Respiratory Syndrome Coronavirus 2 infection and hospitalized due to COVID-19 pneumonia...
2022: Frontiers in Medicine
#31
JOURNAL ARTICLE
Salih Kocaoglu, Adnan Karadas
OBJECTIVE: To evaluate the effectiveness and practicality of shock index (SI), modified shock index (MSI), and age-shock index (Age-SI) in predicting the prognosis, mortality, ICU and service admission, and the need for intermittent mandatory ventilation (IMV) and nasal intermittent mandatory ventilation) (NIMV in the ED patients with chronic obstructive pulmonary disease (COPD) exacerbation. STUDY DESIGN: Retrospective study. PLACE AND DURATION OF STUDY: Balikesir University Faculty of Medicine, Emergency Service, Balıkesir, Turkey, from January 2019 to May 2020...
September 2022: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
#32
JOURNAL ARTICLE
Killen H Briones-Claudett, Mónica H Briones-Claudett, Mariuxi Del Pilar Cabrera Baños, Killen H Briones Zamora, Diana C Briones Marquez, Luc J I Zimmermann, Antonio W D Gavilanes, Michelle Grunauer
BACKGROUND: Bilevel positive airway pressure in spontaneous/time and average volume-assured pressure support (BiPAP·S/T-AVAPS) could maintain an adequate tidal volume by reducing the patient's inspiratory effort; however, this ventilatory strategy has not been compared with other ventilatory modes, especially the conventional BiPAP S/T mode, when noninvasive mechanical ventilation (NIMV) is used. The primary objective of this study was to determine the rate of success and failure of the use of BiPAP·S/T-AVAPS versus BiPAP·S/T alone in patients with mild-to-moderate "de novo" hypoxemic respiratory failure...
2022: Critical Care Research and Practice
#33
JOURNAL ARTICLE
Pablo Rama-Maceiras, Yolanda Sanduende, Manuel Taboada, María Casero, Sonsoles Leal, Rafael Pita-Romero, Ricardo Fernández, Eva López, José Antonio López, Elvira Pita, Ana Tubío, Arancha Rodríguez, Marina Varela, Daniel Campaña, Carla Delgado, Mónica Lombardía, Eva Villar, Pilar Blanco, Adrián Martínez, Ana Sarmiento, Pilar Díaz, María Ojea, Ángel Rodríguez, Lorena Mouriz, Milagros Cid, Lorena Ramos, Teresa Seoane-Pillado
OBJECTIVE: To compare the clinical characteristics, treatments, and evolution of critical patients with COVID-19 pneumonia treated in Intensive Care Units (ICU) after one year of pandemic. METHODOLOGY: Multicenter, prospective study, which included critical COVID-19 patients in 9 ICUs in northwestern Spain. The clinical characteristics, treatments, and evolution of patients admitted to the ICU during the months of March-April 2020 (period 1) were compared with patients admitted in January-February 2021 (period 2)...
July 27, 2022: Enfermedades infecciosas y microbiologia clinica
#34
JOURNAL ARTICLE
Vittorio Abbonante, Alessandro Malara, Martina Chrisam, Samuele Metti, Paolo Soprano, Claudio Semplicini, Luca Bello, Valeria Bozzi, Monica Battiston, Alessandro Pecci, Elena Pegoraro, Luigi De Marco, Paola Braghetta, Paolo Bonaldo, Alessandra Balduini
Endoplasmic reticulum stress is an emerging significant player in the molecular pathology of connective tissue disorders. In response to endoplasmic reticulum stress, cells can upregulate macroautophagy/autophagy, a fundamental cellular homeostatic process used by cells to degrade and recycle proteins or remove damaged organelles. In these scenarios, autophagy activation can support cell survival. Here we demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1 -⁄- (collagen, type VI, alpha 1) null mice display increased intracellular retention of COL6 polypeptides, endoplasmic reticulum stress and apoptosis...
July 20, 2022: Autophagy
#35
RANDOMIZED CONTROLLED TRIAL
Birsen Cirit Ekiz, Nurhan Köksal, Tibel Tuna, Yusuf Taha Güllü
INTRODUCTION: Non-invasive mechanical ventilation (NIMV) is a successful treatment modality in hypercapnic respiratory failure. Patient compliance and mask selection are the most important factors in the success of NIMV. In our prospective randomized study, we aimed to investigate the efficacy of full-face and oronasal masks in the treatment of patients with hypercapnic respiratory failure who underwent NIMV and to investigate the mask compliance of the patients. MATERIALS AND METHODS: In this prospective randomized study, 60 patients with hypercapnic respiratory failure were divided into two groups; the full face mask group (n= 30) and the oronasal mask group (n= 30)...
June 2022: Tüberküloz Ve Toraks
#36
JOURNAL ARTICLE
Patricia Sánchez-Lloria, Roberto Barcala-Furelos, Martín Otero-Agra, Silvia Aranda-García, Óscar Cosido-Cobos, Jorge Blanco-Prieto, Ignacio Muñoz-Barús, Antonio Rodríguez-Núñez
OBJECTIVE: Drowning is one of major public health problem in childhood. The aim of this paper was to describe the characteristics, locations, interventions and outcomes of child drowning in Galicia over 17 years. METHODS: Retrospective study of 100% of data of drowning amongst children aged 0-14 in the 2004-2020 period who were attended by the 061 emergency services in Galicia (Spain) was made. The characteristics of the incident, the victim's profile, location, type of medical care given and whether the victim survived or died were analysed using the Chi Square test to compare relative frequencies, and Odds Ratio to estimate the risk...
June 22, 2022: Revista Española de Salud Pública
#37
JOURNAL ARTICLE
Marina Galdeano Lozano, Julio César Alfaro Álvarez, Núria Parra Macías, Rosario Salas Campos, Sarah Heili Frades, Josep Maria Montserrat, Antoni Rosell Gratacós, Jorge Abad Capa, Olga Parra Ordaz, Francesc López Seguí
Objectives: During the COVID-19 pandemic, the risk of collapse for the health system created great difficulties. We will demonstrate that intermediate respiratory care units (IRCU) provide adequate management of patients with non-invasive respiratory support, which is particularly important for patients with SARS-CoV-2 pneumonia. Methods: A prospective observational study of patients with COVID-19 admitted to the ICU of a tertiary hospital. Sociodemographic data, comorbidities, pharmacological, respiratory support, laboratory and blood gas variables were collected...
May 16, 2022: International Journal of Environmental Research and Public Health
#38
JOURNAL ARTICLE
Murat Duyan, Ali Saridas
OBJECTIVE: This study aims to determine if there is a correlation between differences in optic nerve sheath diameter (ONSD) and changes in PaCO2 and pH values that were measured in the arterial blood gas (ABG) before and after treatment in COPD patients with acute hypercarbic respiratory failure (AHRF). MATERIALS AND METHODS: This study serves as a prospective self-controlled non-randomized trial study conducted in the emergency clinic of a tertiary hospital. Forty-four patients with COPD, who were found to have acidosis and hypercarbia in ABG and had an indication for non-invasive mechanic ventilation (NIMV), were analyzed prospectively...
May 5, 2022: Journal of Ultrasound
#39
JOURNAL ARTICLE
Sevilay Erden, Tülay Artiklar, İlknur Tura, Açelya Türkmen
AIM: The purpose of the study was to assess the level of procedural pain in patients treated in the COVID-19 intensive care unit, in a tertiary university hospital. METHOD: We performed the procedural pain assessment of COVID-19 patients in this study, and 162 (93.6 %) of 173 hospitalized patients assessed during this period. While pain was assessed before, during, and at the 20th minute after endotracheal aspiration, wound care, and position change, which are procedural patient practices, the pain was assessed before, during, and up to the fourth hour after prone positioning, high-flow oxygen therapy (HFOT), and the non-invasive mechanical ventilation (NIMV) procedure...
March 14, 2022: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
#40
JOURNAL ARTICLE
Cem Sahin, Ibrahim Onder Yeniceri, Ozge Oral Tapan, Tumay Cakir, Selmin Dirgen Caylak, Turhan Togan
SUBJECTIVE: Skeletal muscle indexes are known to be one of the important prognostic indicators in many clinical situations. This study aims to evaluate the effects of laboratory values and muscle mass measures such as skeletal muscle area (SMA), skeletal muscle index (SMI), skeletal muscle density (SMD) and skeletal muscle gauge (SMG) obtained from the 12th thoracic vertebra (T12) level of patients hospitalized for COVID-19 infection on prognosis. METHODS: The patients' age, comorbidity index (CCI) scores, gender, anthropometric criteria such as height, weight, and BMI, laboratory values, development of NIMV and IC need during follow-up, length of hospital stay, and hospital mortality were retrospectively screened...
2022: Bratislavské Lekárske Listy
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