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JOURNAL ARTICLE
Maurizio Grassano, Emanuele Koumantakis, Umberto Manera, Antonio Canosa, Rosario Vasta, Francesca Palumbo, Giuseppe Fuda, Paolina Salamone, Giulia Marchese, Federico Casale, Lorena Charrier, Gabriele Mora, Cristina Moglia, Andrea Calvo, Adriano Chiò
OBJECTIVE: Noninvasive mechanical ventilation (NIMV) improves amyotrophic lateral sclerosis (ALS) quality of life and survival. However, data about its effect on disease progression are still lacking. Here, we test whether NIMV use changed the rate of functional decline among ALS patients. METHODS: In this retrospective observational study, we included 448 ALS patients followed up at the ALS Center in Turin, Italy, who underwent NIMV during the disease course. The primary outcome was the change in functional decline after NIMV initiation adjusting for covariates...
January 29, 2024: Annals of Neurology
#2
JOURNAL ARTICLE
Secahattin Bayav, Nazan Çobanoğlu
BACKGROUND: Developments and technological advances in neonatal and pediatric intensive care units have led to a prolonged life expectancy of pediatric patients with chronic respiratory failure. Therefore, the number of hemodynamically stable pediatric patients with chronic respiratory failure who need mechanical ventilator assistance throughout the day has significantly increased. AIMS: Numerous conditions, including parenchymal lung diseases, airway disorders, neuromotor disorders, or respiratory defects, can lead to chronic respiratory failure...
January 22, 2024: Pediatric Pulmonology
#3
JOURNAL ARTICLE
Harinivaas Shanmugavel Geetha, Sushmita Prabhu, Abinesh Sekar, Maya Gogtay, Yuvaraj Singh, Ajay K Mishra, George M Abraham, Suzanne Martin
BACKGROUND: Studies have shown elevated C-reactive protein (CRP) to predict mechanical ventilation (MV) in patients with coronavirus disease 2019 (COVID-19). Its utility is unknown in patients with chronic kidney disease (CKD), who have elevated baseline CRP levels due to chronic inflammation and reduced renal clearance. AIM: To assess whether an association exists between elevated inflammatory markers and MV rate in patients with stages IIIb-V CKD and COVID-19...
December 25, 2023: World Journal of Virology
#4
MULTICENTER STUDY
Carolina S Delgado, Alberto García-Salido, María Á García-Teresa, Amelia Martínez de Azagra-Garde, Inés Leoz-Gordillo, Gema de Lama Caro-Patón, Montserrat Nieto-Moro
BACKGROUND: Asthma is a common cause of admission to the pediatric intensive care unit (PICU). We described and analyzed the therapies applied to children admitted to a tertiary PICU because of asthma. Later, we evaluated high-flow nasal cannula (HFNC) use in these patients and compared their evolution and complications with those who received non-invasive ventilation. METHODS: We conducted a prospective observational study (October 2017-October 2019). Collected data: epidemiological, clinical, respiratory support therapy needed, complementary tests, and PICU and hospital stay...
2023: Boletín Médico del Hospital Infantil de México
#5
JOURNAL ARTICLE
Mircea Stoian, Adina Roman, Alina Boeriu, Danusia Onișor, Sergio Rareș Bandila, Dragoș Florin Babă, Iuliu Cocuz, Raluca Niculescu, Anamaria Costan, Sergiu Ștefan Laszlo, Dragoș Corău, Adina Stoian
From the first reports of SARS-CoV-2, at the end of 2019 to the present, the global mortality associated with COVID-19 has reached 6,952,522 deaths as reported by the World Health Organization (WHO). Early intubation and mechanical ventilation can increase the survival rate of critically ill patients. This prospective study was carried out on 885 patients in the ICU of Mureș County Clinical Hospital, Romania. After applying inclusion and exclusion criteria, a total of 54 patients were included. Patients were monitored during hospitalization and at 6-month follow-up...
September 26, 2023: Biomedicines
#6
JOURNAL ARTICLE
Diana J Valencia Morales, Vikas Bansal, Smith F Heavner, Janna C Castro, Mayank Sharma, Aysun Tekin, Marija Bogojevic, Simon Zec, Nikhil Sharma, Rodrigo Cartin-Ceba, Rahul S Nanchal, Devang K Sanghavi, Abigail T La Nou, Syed A Khan, Katherine A Belden, Jen-Ting Chen, Roman R Melamed, Imran A Sayed, Ronald A Reilkoff, Vitaly Herasevich, Juan Pablo Domecq Garces, Allan J Walkey, Karen Boman, Vishakha K Kumar, Rahul Kashyap
BACKGROUND: The gold standard for gathering data from electronic health records (EHR) has been manual data extraction; however, this requires vast resources and personnel. Automation of this process reduces resource burdens and expands research opportunities. OBJECTIVE: This study aimed to determine the feasibility and reliability of automated data extraction in a large registry of adult COVID-19 patients. MATERIALS AND METHODS: This observational study included data from sites participating in the SCCM Discovery VIRUS COVID-19 registry...
2023: Frontiers in Medicine
#7
JOURNAL ARTICLE
Yewande E Odeyemi, Amos Lal, Erin F Barreto, Allison M LeMahieu, Hemang Yadav, Ognjen Gajic, Phillip Schulte
Current prognostic tools for pneumonia predominantly focus on mortality, often neglecting other crucial outcomes such as the need for advanced respiratory support. The objective of this study was to develop and validate a tool that predicts the early risk of non-occurrence of respiratory deterioration or mortality. We conducted a single-center, retrospective cohort study involving hospitalized adult patients with community-acquired pneumonia (CAP) and acute hypoxic respiratory failure from January 2009 to December 2019 (n = 4379)...
October 4, 2023: Biomol Biomed
#8
JOURNAL ARTICLE
Mehmet Ali Yesiltas, A K Hulya Yilmaz, Yasemin Ozsahin, Baris Sandal, Ziya Salihoglu, Kerem Erkalp
BACKGROUND: Previous studies have shown that hepatic fibrosis indices and rates can be used to predict cardiovascular mortality and morbidity. Our aim with this study was to investigate the effect of aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and fibrosis-4 (FIB-4) index calculated with ALT, AST, and platelet biomarkers, which are simple, fast, and relatively inexpensive and were used in previous studies to predict cardiovascular disease prognosis, on the prediction of postoperative morbidity and early mortality after mitral valve replacement (MVR) surgery...
2023: Annals of Cardiac Anaesthesia
#9
JOURNAL ARTICLE
Agustin García, Rita Galeiras, Sonia Pertega-Díaz
To date, recommendations for the implementation of awake prone positioning in patients with hypoxia secondary to SARSCoV2 infection have been extrapolated from prior studies on respiratory distress. Thus, we carried out a systematic review and metaanalysis to evaluate the benefits of pronation on the oxygenation, need for endotracheal intubation (ETI), and mortality of this group of patients. We carried out a systematic search in the PubMed and Embase databases between June 2020 and November 2021. A randomeffects metaanalysis was performed to evaluate the impact of pronation on the ETI and mortality rates...
April 2023: Journal of Critical Care Medicine
#10
Giovanni Napoli, Martina Rubin, Gianni Cutillo, Paride Schito, Tommaso Russo, Angelo Quattrini, Massimo Filippi, Nilo Riva
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with variable phenotypic expressions which has been associated with autonomic dysfunction. The cardiovascular system seems to be affected especially in the context of bulbar involvement. We describe four new cases of Tako-Tsubo syndrome (TTS) in ALS patients with an appraisal of the literature. We present a late-stage ALS patient with prominent bulbar involvement that presented TTS during hospitalization. We then retrospectively identify three additional ALS-TTS cases reporting relevant clinical findings...
July 28, 2023: International Journal of Molecular Sciences
#11
MULTICENTER STUDY
Ernesto Crisafulli, Giulia Sartori, Alice Vianello, Alessio Maroccia, Elisa Lepori, Massimiliano Quici, Chiara Cogliati, Massimo Salvetti, Anna Paini, Carlo Aggiusti, Fabio Bertacchini, Fabiana Busti, Giacomo Marchi, Maria Lorenza Muiesan, Domenico Girelli
During the first two waves of the COVID-19 emergency in Italy, internal medicine high-dependency wards (HDW) have been organized to manage patients with acute respiratory failure (ARF). There is heterogeneous evidence about the feasibility and outcomes of non-invasive respiratory supports (NIRS) in settings outside the intensive care unit (ICU), including in patients deemed not eligible for intubation (i.e., with do-not-intubate, DNI status). Few data are available about the different NIRS modalities applied to ARF patients in the newly assembled internal medicine HDW...
September 2023: Internal and Emergency Medicine
#12
JOURNAL ARTICLE
Po-Yang Tsou, Lystra P Hayden
OBJECTIVE (S): Children with bronchopulmonary dysplasia (BPD) are at higher risk of respiratory insufficiency during respiratory illness. We aimed to investigate whether obstructive sleep apnea (OSA) is associated with increased morbidity among children with BPD hospitalized with acute respiratory illnesses. STUDY DESIGN: Hospital discharge records were obtained from the Kid's Inpatient Database for children <21 years of age with BPD hospitalized for acute respiratory illness between 1997 and 2012...
September 2023: Sleep Medicine
#13
REVIEW
Nurel Erturk, Adem Celik, Ebru CalikKutukcu
BACKGROUND: The effects of expiratory muscle strength training (EMST) with different intensity on stages of sleep were not examined in patients with obstructive sleep apnea syndrome (OSAS). OBJECTIVES: The aim of this study was to compare the effects of high- and low-intensity EMST (H-EMST and L-EMST) on disease severity, sleep stages, disease-related symptoms, daytime sleepiness, fatigue severity, and sleep quality in adult patients with severe OSAS using non-invasive mechanical ventilation (NIMV)...
April 21, 2023: Heart & Lung: the Journal of Critical Care
#14
MULTICENTER STUDY
Divya A Shankar, Allan J Walkey, Finn J Hawkins, Nicholas A Bosch, Daniel Peterson, Anica C Law
BACKGROUND: In the absence of evidence-based strategies to improve patient outcomes, the management of patients with severe idiopathic pulmonary fibrosis (IPF) exacerbations may vary widely across centres. We assessed between-hospital variation in practices and mortality for patients with severe IPF exacerbations. METHODS: Using the Premier Healthcare Database from 1 October 2015 to 31 December 2020, we identified patients admitted to intensive care unit (ICU) or intermediate care unit with an IPF exacerbation...
April 2023: BMJ Open Respiratory Research
#15
JOURNAL ARTICLE
Jovana Maskovic, Aleksandra Ilic, Vladimir Zugic, Zorica Stevic, Mihailo I Stjepanovic
INTRODUCTION: The most common cause of death in patients with amyotrophic lateral sclerosis (ALS) is respiratory failure, often in the period of 2-5 years, with a small percentage of patients surviving up to 10 years or more. The aim of the study was to evaluate the significance of pulmonary function tests in prediction of mortality and definition of indications for noninvasive mechanical ventilation (NIMV). MATERIAL AND METHODS: This retrospective-prospective study was performed at the Clinic of Pulmonology, Clinical Centre of Serbia in the period from January 2015 to December 2017...
2023: Archives of Medical Science: AMS
#16
JOURNAL ARTICLE
Ayfer Kaya Gök, Aygen Turkmen, Emine Köse, Ferhat Çengel, Serpil Şehirlioglu
BACKGROUND: Intensive care workers received the largest share of the COVID-19 pandemic, which caused nightmares to the whole world. In COVID-19 pneumonia cases which had high mortality rates, many prognostic factors and laboratory examinations were tried to evaluate the clinical severity quickly and accurately.This study was planned to investigate a correlation between the initially ventilation strategy and major prognostic parameters and CT scores in patients admitted to intensive care unit (ICU)...
February 2023: Turkish Journal of Trauma & Emergency Surgery: TJTES
#17
JOURNAL ARTICLE
Marco Bongiovanni, Giuseppe Barilaro, Francesco Bini
OBJECTIVES: To assess long-term clinical, radiological and functional follow-up of patients hospitalized for SARS-CoV-2 pneumonia of different grade of severity. METHODS: Two-hundred-thirty-three patients (Group 1, patients needed invasive mechanical ventilation -IMV-, n=69; Group 2, patients needed NIMV, n=78; Group 3, patients needed < 12 l/min of O2 supply, n=96) with a post-discharge follow-up>12 months were studied. Follow-up visits, chest CT scan and pulmonary function tests (DLCO, 6-minutes walking tests -6MWT-, spirometry) were done at 3, 6 and 12 months after discharge...
January 25, 2023: Journal of Medical Virology
#18
JOURNAL ARTICLE
Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients.
Jessica González, Jordi de Batlle, Iván D Benítez, Gerard Torres, Sally Santisteve, Adriano D S Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Maria Aguilà, Fatty Seck, Adrián Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernández, Rosario Menéndez, José Ángel Lorente, Oscar Peñuelas, Dario Garcia-Gasulla, Yhivian Peñasco, Pilar Ricart, Elena Abril Palomares, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Belén Beteré, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Inmaculada Salvador-Adell, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, José M Gómez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Covadonga Rodríguez, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M Albaiceta, Maria Del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Jose M Añón, Cristina Carbajales Pérez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Emili Diaz, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbé
INTRODUCTION: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors. METHODS: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-confirmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit...
January 7, 2023: Archivos de Bronconeumología
#19
JOURNAL ARTICLE
Natieli Flores Fernandes, Isabella Ferreira Costa, Karla Nunes Pereira, José Antonio Mainardi de Carvalho, Clóvis Paniz
Patients with the most severe form of coronavirus disease 2019 (COVID-19) often require invasive ventilation. Determining the best moment to intubate a COVID-19 patient is complex decision and can result in important consequences for the patient. Therefore, markers that could aid in clinical decision-making such as hematological indices are highly useful. These markers are easy to calculate, do not generate extra costs for the laboratory, and are readily implemented in routine practice. Thus, this study aimed to investigate differences in the ratios calculated from the hemogram between patients with and without the need for invasive mechanical ventilation (IMV) and a control group...
January 20, 2023: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#20
JOURNAL ARTICLE
Elisa Reitano, Francesco Gavelli, Giacomo Iannantuoni, Silvia Fattori, Chiara Airoldi, Simone Matranga, Stefano Piero Bernardo Cioffi, Silvia Ingala, Francesco Virdis, Martina Rizzo, Nicole Marcomini, Alberto Motta, Andrea Spota, Matteo Maestrone, Roberta Ragozzino, Michele Altomare, Luigi Mario Castello, Francesco Della Corte, Rosanna Vaschetto, Gian Carlo Avanzi, Osvaldo Chiara, Stefania Cimbanassi
Chest trauma management often requires the use of invasive and non-invasive ventilation. To date, only a few studies investigated the predictors of the need for ventilatory support. Data on 1080 patients with chest trauma managed in two different centers were retrospectively analyzed. Univariate and multivariate analyses were performed to identify the predictors of tracheal intubation (TI), non-invasive mechanical ventilation (NIMV), and mortality. Rib fractures ( p = 0.0001) fracture of the scapula, clavicle, or sternum ( p = 0...
January 16, 2023: Journal of Clinical Medicine
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