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https://www.readbyqxmd.com/read/28507526/behavioral-and-neural-manifestations-of-reward-memory-in-carriers-of-low-expressing-versus-high-expressing-genetic-variants-of-the-dopamine-d2-receptor
#1
Anni Richter, Adriana Barman, Torsten Wüstenberg, Joram Soch, Denny Schanze, Anna Deibele, Gusalija Behnisch, Anne Assmann, Marieke Klein, Martin Zenker, Constanze Seidenbecher, Björn H Schott
Dopamine is critically important in the neural manifestation of motivated behavior, and alterations in the human dopaminergic system have been implicated in the etiology of motivation-related psychiatric disorders, most prominently addiction. Patients with chronic addiction exhibit reduced dopamine D2 receptor (DRD2) availability in the striatum, and the DRD2 TaqIA (rs1800497) and C957T (rs6277) genetic polymorphisms have previously been linked to individual differences in striatal dopamine metabolism and clinical risk for alcohol and nicotine dependence...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28503114/antidepressant-induced-dopamine-receptor-dysregulation-a-valid-animal-model-of-manic-depressive-illness
#2
REVIEW
Francesca Demontis, Francesca Serra, Gino Serra
BACKGROUND: Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28502844/a-novel-approach-to-map-induced-activation-of-neuronal-networks-using-chemogenetics-and-functional-neuroimaging-in-rats-a-proof-of-concept-study-on-the-mesocorticolimbic-system
#3
Theresia J M Roelofs, Jeroen P H Verharen, Geralda A F van Tilborg, Linde Boekhoudt, Annette van der Toorn, Johannes W de Jong, Mieneke C M Luijendijk, Willem M Otte, Roger A H Adan, Rick M Dijkhuizen
Linking neural circuit activation at whole-brain level to neuronal activity at cellular level remains one of the major challenges in neuroscience research. We set up a novel functional neuroimaging approach to map global effects of locally induced activation of specific midbrain projection neurons using chemogenetics (Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-technology) combined with pharmacological magnetic resonance imaging (phMRI) in the rat mesocorticolimbic system. Chemogenetic activation of DREADD-targeted mesolimbic or mesocortical pathways, i...
May 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28501595/corticolimbic-circuitry-in-the-modulation-of-chronic-pain-and-substance-abuse
#4
REVIEW
Anna M W Taylor
The transition from acute to chronic pain is accompanied by increased engagement of emotional and motivational circuits. Adaptations within this corticolimbic circuitry contribute to the cellular and behavioral maladaptations associated with chronic pain. Central regions within the corticolimbic brain include the mesolimbic dopamine system, the amygdala, and the medial prefrontal cortex. The evidence reviewed herein supports the notion that chronic pain induces significant changes within these corticolimbic regions that contribute to the chronicity and intractability of pain...
May 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28495611/hiv-1-tat-protein-enhances-sensitization-to-methamphetamine-by-affecting-dopaminergic-function
#5
James P Kesby, Julia A Najera, Benedetto Romoli, Yiding Fang, Liana Basova, Amanda Birmingham, Maria Cecilia G Marcondes, Davide Dulcis, Svetlana Semenova
Methamphetamine abuse is common among humans with immunodeficiency virus (HIV). The HIV-1 regulatory protein TAT induces dysfunction of mesolimbic dopaminergic systems which may result in impaired reward processes and contribute to methamphetamine abuse. These studies investigated the impact of TAT expression on methamphetamine-induced locomotor sensitization, underlying changes in dopamine function and adenosine receptors in mesolimbic brain areas and neuroinflammation (microgliosis). Transgenic mice with doxycycline-induced TAT protein expression in the brain were tested for locomotor activity in response to repeated methamphetamine injections and methamphetamine challenge after a 7-day abstinence period...
May 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28494748/the-novelty-of-bupropion-as-a-dopaminergic-antidepressant-for-the-treatment-of-adult-attention-deficit-hyperactive-disorder
#6
Kanit Tha Deang, Hatta Sidi, Hazli Zakaria, Raja Lope Adam, Srijit Das, Nurul Hazwani Hatta, Muhammad Hatta, Kok Wei Wee
Attention deficit hyperactive disorder (ADHD), a hyperactivity disorder that is prevalent among children may continue as an adulthood attention deficit. To date, treating an individual with an adult ADHD may be an arduous task as it involved numerous challenges, such as a need for high index of suspicion to diagnose this medical condition. Many psychiatric disorders masquerade as ADHD and delayed the necessary assessment and proper treatment for the debilitating medical condition. Adult ADHD would also be misdiagnosed (or under diagnosed) due to the facts that this medical condition is being masked by his or her high level of intellectuality achievement...
May 11, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28487223/obesogenic-diet-intake-during-pregnancy-programs-aberrant-synaptic-plasticity-and-addiction-like-behavior-to-a-palatable-food-in-offspring
#7
Alberto Camacho, Larisa Montalvo-Martinez, Robbi E Cardenas-Perez, Lizeth Fuentes-Mera, Lourdes Garza-Ocañas
Contextual food conditioned behaviors require plasticity of glutamatergic neurotransmission in the reward system, involving changes in the expression of including a-amino-3-hydroxy-5- methylisoxazole-4-propionate receptors (AMPA), N-methyl-d-aspartic acid (NMDA) and metabotropic glutamate 2,3 (mGlur 2,3). However, the role of changes in glutamatergic synaptic markers on energy-dense palatable food preference during development has not been described. Here, we determine the effect of nutritional programing during gestation on fat food choices using a conditioned place preference (CPP) test and an operant training response and its effect on glutamatergic markers in the nucleus accumbens (Nac) shell and prefrontal cortex (PFC)...
May 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28479265/the-amphetamine-associated-context-exerts-a-stronger-motivational-effect-in-low-anxiety-rats-than-in-high-anxiety-rats
#8
Małgorzata Lehner, Marek Gryz, Aleksandra Wisłowska-Stanek, Danuta Turzyńska, Alicja Sobolewska, Anna Skórzewska, Adam Płaźnik
This study used the conditioned place preference test to explore the effects of subchronic amphetamine administration on drug-associated cues in rats with different emotional reactivity. We also examined the changes in markers of dopaminergic activity in brain regions in response to the amphetamine-paired context, after a withdrawal period preceded by subchronic amphetamine treatment. We used low-anxiety (LR) and high-anxiety (HR) rats, which are known to exhibit distinct levels of susceptibility to amphetamine...
May 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28469558/intracellular-fibroblast-growth-factor-14-emerging-risk-factor-for-brain-disorders
#9
REVIEW
Jessica Di Re, Paul A Wadsworth, Fernanda Laezza
The finely tuned regulation of neuronal firing relies on the integrity of ion channel macromolecular complexes. Minimal disturbances of these tightly regulated networks can lead to persistent maladaptive plasticity of brain circuitry. The intracellular fibroblast growth factor 14 (FGF14) belongs to the nexus of proteins interacting with voltage-gated Na+ (Nav) channels at the axonal initial segment. Through isoform-specific interactions with the intracellular C-terminal tail of neuronal Nav channels (Nav1.1, Nav1...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28466092/repeated-social-defeat-and-the-rewarding-effects-of-cocaine-in-adult-and-adolescent-mice-dopamine-transcription-factors-probdnf-signaling-pathways-and-the-trkb-receptor-in-the-mesolimbic-system
#10
Sandra Montagud-Romero, Cristina Nuñez, M Carmen Blanco-Gandia, Elena Martínez-Laorden, María A Aguilar, Javier Navarro-Zaragoza, Pilar Almela, Maria-Victoria Milanés, María-Luisa Laorden, José Miñarro, Marta Rodríguez-Arias
RATIONALE: Repeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents. OBJECTIVE: The aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine and levels of the transcription factors Pitx3 and Nurr1 in the ventral tegmental area (VTA), the dopamine transporter (DAT), the D2 dopamine receptor (D2DR) and precursor of brain-derived neurotrophic factor (proBDNF) signaling pathways, and the tropomyosin-related kinase B (TrkB) receptor in the nucleus accumbens (NAc) in adult and adolescent mice...
May 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28458129/the-acute-effect-of-pleasurable-music-on-craving-for-alcohol-a-pilot-crossover-study
#11
Walter S Mathis, Xiaotong Han
Chronic administration of drugs of abuse leads to a dopamine deficient state in the mesolimbic system, causing dysphoria in abstinence and contributing to craving and return to use. Recent functional imaging studies have shown that listening to personally pleasing music activates the mesolimbic reward system in a fashion similar to drugs of abuse. It has been proposed that such activation could ameliorate the dysphoria and craving of the hypodopaminergic state. The present study sought to evaluate the efficacy of listening to personally pleasing or moving music on reducing craving in abstinent alcoholics using a single-blind, within-subject randomized block design, with three randomly determined presentations of each condition...
April 25, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28457669/%C3%AE-6%C3%AE-2-nicotinic-acetylcholine-receptors-influence-locomotor-activity-and-ethanol-consumption
#12
Helen M Kamens, Colette Peck, Caitlin Garrity, Alex Gechlik, Brenita C Jenkins, Akshat Rajan
Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system have been implicated in ethanol behaviors. In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption and sedation. A limitation of these studies is that the alteration in the receptor was present throughout development. The recently described α6β2 antagonist, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI), now makes it possible to test for the involvement of these receptors using a pharmacological approach...
April 27, 2017: Alcohol
https://www.readbyqxmd.com/read/28456768/corticotropin-releasing-factor-receptor-1-antagonist-differentially-inhibits-freezing-behavior-and-changes-gamma-aminobutyric-acidergic-activity-in-the-amygdala-in-low-and-high-anxiety-rats
#13
A Skorzewska, A Wislowska-Stanek, M Lehner, D Turzynska, A Sobolewska, P Krzascik, A Plaznik
The aim of this study was to examine the effects of non-peptide corticotropin-releasing factor receptor 1 (CRF1) antagonist (antalarmin) administration on rat conditioned fear responses and gamma-aminobutyric acid (GABA)-ergic brain activity (GAD67 expression and GABA concentration) in low-anxiety (LR) and high-anxiety (HR) rats. The animals were divided into the LR and HR groups based on the duration of their conditioned freezing response in the first contextual fear test. After 28 days, the animals were re-subjected to the contextual fear training and test...
February 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28445429/exploring-the-behavioral-and-metabolic-phenotype-generated-by-re-introduction-of-the-ghrelin-receptor-in-the-ventral-tegmental-area
#14
Louise J Skov, Morten Jensen, Søren H Christiansen, Cecilia Ratner, David P D Woldbye, Birgitte Holst
Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this study, we re-introduced the Ghr-R in VTA neurons in Ghr-R knockout mice (Ghr-R(VTA) mice) to specifically study the importance of the constitutively active Ghr-R for VTA neuronal signaling. Our results showed that re-introduction of the Ghr-R in the VTA had no impact on body weight or food intake under basal conditions...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28434991/the-control-of-sleep-and-wakefulness-by-mesolimbic-dopamine-systems
#15
REVIEW
Yo Oishi, Michael Lazarus
The mesolimbic dopamine pathway between the ventral tegmental area (VTA) and the nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings indicate that the VTA and NAc are also involved in sleep/wake regulation - the topic of this review. First, we present an overview of the growing evidence from rodent studies revealing a wake-regulatory role of VTA dopamine neurons. We also discuss brain areas and their neurotransmitters or neuromodulators that may regulate the activity of wake-promoting VTA dopamine neurons...
April 20, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28432029/suppression-of-reward-induced-dopamine-release-in-the-nucleus-accumbens-in-animal-models-of-depression-differential-responses-to-drug-treatment
#16
Saki Minami, Hiroshi Satoyoshi, Soichiro Ide, Takeshi Inoue, Mitsuhiro Yoshioka, Masabumi Minami
Anhedonia, the loss of interest or pleasure in previously enjoyable activities, is a core symptom of major depressive disorder, suggesting that the brain reward system may be dysfunctional in this condition. Neurochemical changes in the mesolimbic dopamine (DA) system are not fully understood in animal models of depression. We investigated reward (30% sucrose intake)-induced DA release in the nucleus accumbens (NAc) and the effect of chronic treatment with the antidepressant escitalopram (5mg/kg, intraperitoneally twice daily for 3 weeks) in two animal models of depression...
April 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28422060/clarifying-the-ghrelin-system-s-ability-to-regulate-feeding-behaviours-despite-enigmatic-spatial-separation-of-the-ghsr-and-its-endogenous-ligand
#17
REVIEW
Alexander Edwards, Alfonso Abizaid
Ghrelin is a hormone predominantly produced in and secreted from the stomach. Ghrelin is involved in many physiological processes including feeding, the stress response, and in modulating learning, memory and motivational processes. Ghrelin does this by binding to its receptor, the growth hormone secretagogue receptor (GHSR), a receptor found in relatively high concentrations in hypothalamic and mesolimbic brain regions. While the feeding and metabolic effects of ghrelin can be explained by the effects of this hormone on regions of the brain that have a more permeable blood brain barrier (BBB), ghrelin produced within the periphery demonstrates a limited ability to reach extrahypothalamic regions where GHSRs are expressed...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28417291/reward-prediction-errors-in-drug-addiction-and-parkinson-s-disease-from-neurophysiology-to-neuroimaging
#18
REVIEW
Isabel García-García, Yashar Zeighami, Alain Dagher
PURPOSE OF REVIEW: Surprises are important sources of learning. Cognitive scientists often refer to surprises as "reward prediction errors," a parameter that captures discrepancies between expectations and actual outcomes. Here, we integrate neurophysiological and functional magnetic resonance imaging (fMRI) results addressing the processing of reward prediction errors and how they might be altered in drug addiction and Parkinson's disease. RECENT FINDINGS: By increasing phasic dopamine responses, drugs might accentuate prediction error signals, causing increases in fMRI activity in mesolimbic areas in response to drugs...
June 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28413623/glutamate-plasticity-woven-through-the-progression-to-alcohol-use-disorder-a-multi-circuit-perspective
#19
REVIEW
Lara Hwa, Joyce Besheer, Thomas Kash
Glutamate signaling in the brain is one of the most studied targets in the alcohol research field. Here, we report the current understanding of how the excitatory neurotransmitter glutamate, its receptors, and its transporters are involved in low, episodic, and heavy alcohol use. Specific animal behavior protocols can be used to assess these different drinking levels, including two-bottle choice, operant self-administration, drinking in the dark, the alcohol deprivation effect, intermittent access to alcohol, and chronic intermittent ethanol vapor inhalation...
2017: F1000Research
https://www.readbyqxmd.com/read/28411257/relief-of-pain-depressed-behavior-in-rats-by-activation-of-d1-like-dopamine-receptors
#20
Matthew F Lazenka, Kelen C Freitas, Sydney Henck, S Stevens Negus
Clinically significant pain often includes depression of both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists in a preclinical assay of pain-depressed operant responding. Male Sprague-Dawley rats with chronic indwelling microelectrodes in the medial forebrain bundle were trained in an intracranial self-stimulation (ICSS) procedure to press a lever for pulses of electrical brain stimulation...
April 14, 2017: Journal of Pharmacology and Experimental Therapeutics
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