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https://www.readbyqxmd.com/read/29337226/glp-1-signaling-and-alcohol-mediated-behaviors-preclinical-and-clinical-evidence
#1
REVIEW
Elisabet Jerlhag
Alcohol addiction, affecting approximately four percent of the population, contributes significantly to the global burden of diseases and is a substantial cost to the society. The neurochemical mechanisms regulating alcohol mediated behaviors is complex and in more recent years a new physiological role of the gut-brain peptides, traditionally known to regulate appetite and food intake, have been suggested. Indeed, regulators of alcohol-mediated behaviors. One of these gut-brain peptides is the annorexigenic peptide glucagon-like peptide-1 (GLP-1), Preclinical studies show that GLP-1 receptor activation, either by GLP-1 or analogues, attenuate the ability of alcohol to activate the mesolimbic dopamine system as well as decrease alcohol consumption and operant self-administration...
January 11, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29336819/identification-of-a-corticohabenular-circuit-regulating-socially-directed-behavior
#2
Madhurima Benekareddy, Tevye Jason Stachniak, Andreas Bruns, Frederic Knoflach, Markus von Kienlin, Basil Künnecke, Anirvan Ghosh
BACKGROUND: The prefrontal cortex (PFC) has been implicated in the pathophysiology of social dysfunction, but the specific circuit partners mediating PFC function in health and disease are unclear. METHODS: The excitatory designer receptor exclusively activated by designer drugs (DREADD) hM3Dq was used to induce PFC activation during social behavior measured in the three-chamber sociability assay (rats/mice). Functional magnetic resonance imaging was combined with hM3Dq-mediated PFC activation to identify novel nodes in the "social brain" in a hypothesis-free manner...
December 2, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29335538/speed-related-activation-in-the-mesolimbic-dopamine-system-during-the-observation-of-driver-view-videos
#3
Hiroyuki Sakai, Takafumi Ando, Norihiro Sadato, Yuji Uchiyama
Despite the ubiquity and importance of speeding offenses, there has been little neuroscience research regarding the propensity for speeding among vehicle drivers. In the current study, as a first attempt, we examined the hypothesis that visual inputs during high-speed driving would activate the mesolimbic dopaminergic system that plays an important role in mediating motivational craving. To this end, we used functional magnetic resonance imaging to identify speed-related activation changes in mesolimbic dopaminergic regions during the observation of driver-view videos in two groups that differed in self-reported speeding propensity...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329678/apelin-13-ameliorates-cognitive-impairments-in-6-hydroxydopamine-induced-substantia-nigra-lesion-in-rats
#4
Elham Haghparast, Saeed Esmaeili-Mahani, Mehdi Abbasnejad, Vahid Sheibani
Although Parkinson's disease (PD) is well known with its motor deficits, the patients often suffer from cognitive dysfunction. Apelin, as the endogenous ligand of the APJ receptor, is found in several brain regions such as substantia nigra and mesolimbic pathway. However, the role of apelin in cognition and cognitive disorders has not been fully clarified. In this study the effects of apelin-13 were investigated on cognitive disorders in rat Parkinsonism experimental model. 6-hydroxydopamine (6-OHDA) was administrated into the substantia nigra...
January 5, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29318488/disrupted-topological-organization-of-the-frontal-mesolimbic-network-in-obese-patients
#5
Qianqian Meng, Yu Han, Gang Ji, Guanya Li, Yang Hu, Li Liu, Qingchao Jin, Karen M von Deneen, Jizheng Zhao, Guangbin Cui, Huaning Wang, Dardo Tomasi, Nora D Volkow, Jixin Liu, Yongzhan Nie, Yi Zhang, Gene-Jack Wang
Neuroimaging studies have revealed brain functional abnormalities in frontal-mesolimbic regions in obesity. However, the effects of obesity on brain network topology remains largely unknown. In the current study, we employed resting-state functional magnetic resonance imaging and graph theory methods to investigate obesity-related changes in brain network topology in 26 obese patients and 28 normal weight subjects. Results revealed that the whole-brain networks of the two groups exhibited typical features of small-world topology...
January 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29301039/defining-the-locus-of-dopaminergic-dysfunction-in-schizophrenia-a-meta-analysis-and-test-of-the-mesolimbic-hypothesis
#6
Robert McCutcheon, Katherine Beck, Sameer Jauhar, Oliver D Howes
Background: Studies using positron emission tomography to image striatal dopamine function, have demonstrated that individuals with schizophrenia display increases in presynaptic function. Mesolimbic dysfunction specifically, has previously been suggested to underlie psychotic symptoms. This has not been directly tested in vivo, and the precise anatomical locus of dopamine dysfunction within the striatum remains unclear. The current article investigates the magnitude of dopaminergic abnormalities in individuals with schizophrenia, and determines how the magnitude of abnormality varies across functional subdivisions of the striatum...
December 28, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29298426/interrogating-the-spatiotemporal-landscape-of-neuromodulatory-gpcr-signaling-by-real-time-imaging-of-camp-in-intact-neurons-and-circuits
#7
Brian S Muntean, Stefano Zucca, Courtney M MacMullen, Maria T Dao, Caitlin Johnston, Hideki Iwamoto, Randy D Blakely, Ronald L Davis, Kirill A Martemyanov
Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology. How numerous GPCRs integrate neuromodulatory inputs while accommodating diversity of incoming signals is poorly understood. In this study, we develop an in vivo tool and analytical suite for analyzing GPCR responses by monitoring the dynamics of a key second messenger, cyclic AMP (cAMP), with excellent quantitative and spatiotemporal resolution in various neurons...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29289614/sexual-odor-preference-and-dopamine-release-in-the-nucleus-accumbens-by-estrous-olfactory-cues-in-sexually-na%C3%A3-ve-and-experienced-male-rats
#8
Masaya Fujiwara, Atsuhiko Chiba
Sexual behavior is a natural reward that activates mesolimbic dopaminergic system. Microdialysis studies have shown that extracellular level of dopamine (DA) in the nucleus accumbens (NAcc) significantly increases during copulation in male rats. The NAcc DA level is also known to be increased during the presentation of a sexually receptive female before mating. This rise in DA was probably associated with sexual motivation elicited by incentive stimuli from the receptive female. These microdialysis studies, however, did not thoroughly investigated if olfactory stimuli from estrous females could significantly increase the extracellular DA in the NAcc of male rats...
December 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29276735/circuit-and-synaptic-mechanisms-of-repeated-stress-perspectives-from-differing-contexts-duration-and-development
#9
REVIEW
Kevin G Bath, Scott J Russo, Kristen E Pleil, Eric S Wohleb, Ronald S Duman, Jason J Radley
The current review is meant to synthesize research presented as part of a symposium at the 2016 Neurobiology of Stress workshop in Irvine California. The focus of the symposium was "Stress and the Synapse: New Concepts and Methods" and featured the work of several junior investigators. The presentations focused on the impact of various forms of stress (altered maternal care, binge alcohol drinking, chronic social defeat, and chronic unpredictable stress) on synaptic function, neurodevelopment, and behavioral outcomes...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/29249995/homer2-and-alcohol-a-mutual-interaction
#10
REVIEW
Valentina Castelli, Anna Brancato, Angela Cavallaro, Gianluca Lavanco, Carla Cannizzaro
The past two decades of data derived from addicted individuals and preclinical animal models of addiction implicate a role for the excitatory glutamatergic transmission within the mesolimbic structures in alcoholism. The cellular localization of the glutamatergic receptor subtypes, as well as their signaling efficiency and function, are highly dependent upon discrete functional constituents of the postsynaptic density, including the Homer family of scaffolding proteins. The consequences of repeated alcohol administration on the expression of the Homer family proteins demonstrate a crucial and active role, particularly for the expression of Homer2 isoform, in regulating alcohol-induced behavioral and cellular neuroplasticity...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29248527/inhibiting-mesolimbic-dopamine-neurons-reduces-the-initiation-and-maintenance-of-instrumental-responding
#11
Sarah Fischbach-Weiss, Rebecca M Reese, Patricia H Janak
Mesolimbic dopamine perturbations modulate performance of reward-seeking behavior, with tasks requiring high effort being especially vulnerable to disruption of dopamine signaling. Previous work primarily investigated longer-term perturbations such as receptor antagonism and dopamine depletion, which constrain the ability to assess dopamine contributions to effort expenditure in isolation from other behavior events, such as reward consumption. Also unclear is if dopamine is required for both initiation and maintenance when a sequence of multiple instrumental responses is required...
December 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/29243121/neural-processing-of-food-and-monetary-rewards-is-modulated-by-metabolic-state
#12
Mushfa Yousuf, Marcus Heldmann, Martin Göttlich, Thomas F Münte, Nuria Doñamayor
In humans, food is considered a powerful primary reinforcer, whereas money is a secondary reinforcer, as it gains a value through learning experience. Here, we aimed to identify the neural regions supporting the processing of food-related reinforcers, relate it to the neural underpinnings of monetary reinforcers, and explore their modulation by metabolic state (hunger vs satiety). Twenty healthy male participants were tested in two experimental sessions, once hungry and once satiated, using functional magnetic resonance imaging...
December 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29241537/nucleus-accumbens-dopamine-signaling-regulates-sexual-preference-for-females-in-male-mice
#13
Yamit Beny-Shefer, Noga Zilkha, Yael Lavi-Avnon, Nadav Bezalel, Ilana Rogachev, Alexander Brandis, Molly Dayan, Tali Kimchi
Sexual preference for the opposite sex is a fundamental behavior underlying reproductive success, but the neural mechanisms remain unclear. Here, we examined the role of dopamine signaling in the nucleus accumbens core (NAcc) in governing chemosensory-mediated preference for females in TrpC2-/- and wild-type male mice. TrpC2-/- males, deficient in VNO-mediated signaling, do not display mating or olfactory preference toward females. We found that, during social interaction with females, TrpC2-/- males do not show increased NAcc dopamine levels, observed in wild-type males...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29237282/modulation-of-salience-network-intranetwork-resting-state-functional-connectivity-in-women-with-chronic-migraine
#14
X Michelle Androulakis, Chris Rorden, B Lee Peterlin, Kaitlin Krebs
Objective To investigate the intranetwork resting state fMRI connectivity within the Salience Network of chronic migraine with and without medication overuse headache. Methods We compared 351 pairs of intranetwork connectivity in chronic migraine (n = 13) and chronic migraine with medication overuse headache (n = 16) compared to matched controls, and between each chronic migraine subgroup. Results Compared to controls, 17 pairs of intranetwork connections in chronic migraine and 27 pairs in chronic migraine with medication overuse headache were decreased...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29236922/effects-of-n-acetylcysteine-on-amphetamine-induced-sensitization-in-mice
#15
Ana P Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S Gama, Elaine Elisabetsky
OBJECTIVE: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. METHODS: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29221808/a-cannabinoid-receptor-antagonist-attenuates-ghrelin-induced-activation-of-the-mesolimbic-dopamine-system-in-mice
#16
Aimilia Lydia Kalafateli, Daniel Vallöf, Julia Winsa Jörnulf, Markus Heilig, Elisabet Jerlhag
Ghrelin has been attributed various physiological processes including food intake and reward regulation, through activation of the mesolimbic dopamine system. Reward modulation involves the mesolimbic dopamine system, consisting of the ventral tegmental area (VTA) dopamine neurons targeting nucleus accumbens (NAc), a system that ghrelin activates through VTA-dependent mechanisms. In the first study, we found that systemic intraperitoneal (ip) administration of rimonabant attenuated intracerebroventricular (icv) ghrelin's ability to cause locomotor stimulation and NAc dopamine release in mice...
December 5, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29217684/retrieval-demands-adaptively-change-striatal-old-new-signals-and-boost-subsequent-long-term-memory
#17
Nora A Herweg, Tobias Sommer, Nico Bunzeck
The striatum is a central part of the dopaminergic mesolimbic system and contributes both to the encoding and retrieval of long-term memories. In this regard, the co-occurrence of striatal novelty and retrieval success effects in independent studies underlines the structure's double duty and suggests dynamic contextual adaption. To test this hypothesis and further investigate the underlying mechanisms of encoding and retrieval dynamics, human subjects viewed pre-familiarized scene images intermixed with new scenes and classified them as indoor vs...
December 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29216450/endocannabinoid-actions-on-cortical-terminals-orchestrate-local-modulation-of-dopamine-release-in-the-nucleus-accumbens
#18
Yolanda Mateo, Kari A Johnson, Dan P Covey, Brady K Atwood, Hui-Ling Wang, Shiliang Zhang, Iness Gildish, Roger Cachope, Luigi Bellocchio, Manuel Guzmán, Marisela Morales, Joseph F Cheer, David M Lovinger
Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper of goal-directed behavior. Here we report that extracellular DA increases induced by selective optogenetic activation of cholinergic neurons in the nucleus accumbens (NAc) are inhibited by CB1 agonists and eCBs...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29209998/rodent-ultrasonic-vocalizations-as-biomarkers-of-future-alcohol-use-a-predictive-analytic-approach
#19
Nitish Mittal, W Todd Maddox, Timothy Schallert, Christine L Duvauchelle
Excessive alcohol consumption has a vast, negative impact on society. Rodent models have been successful in furthering our understanding of the biological underpinnings that drive alcohol consumption. Rodents emit ultrasonic vocalizations (USVs) that are each composed of several acoustic characteristics (e.g., frequency, duration, bandwidth, power). USVs reflect neurotransmitter activity in the ascending limb of the mesolimbic dopaminergic and cholinergic neurotransmitter systems and serve as noninvasive, real-time biomarkers of dopaminergic and cholinergic neurotransmission in the limbic system...
December 5, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29187755/a-mouse-model-of-the-schizophrenia-associated-1q21-1-microdeletion-syndrome-exhibits-altered-mesolimbic-dopamine-transmission
#20
Jacob Nielsen, Kim Fejgin, Florence Sotty, Vibeke Nielsen, Arne Mørk, Claus T Christoffersen, Leonid Yavich, Jes B Lauridsen, Dorte Clausen, Peter H Larsen, Jan Egebjerg, Thomas M Werge, Pekka Kallunki, Kenneth V Christensen, Michael Didriksen
1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model (Df(h1q21)/+) and characterized it in a broad test battery focusing on schizophrenia-related assays. Df(h1q21)/+ mice displayed increased hyperactivity in response to amphetamine challenge and increased sensitivity to the disruptive effects of amphetamine and phencyclidine hydrochloride (PCP) on prepulse inhibition...
November 30, 2017: Translational Psychiatry
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