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mesocorticolimbic

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https://www.readbyqxmd.com/read/29587625/the-effects-of-intranasal-oxytocin-on-reward-circuitry-responses-in-children-with-autism-spectrum-disorder
#1
R K Greene, M Spanos, C Alderman, E Walsh, J Bizzell, M G Mosner, J L Kinard, G D Stuber, T Chandrasekhar, L C Politte, L Sikich, G S Dichter
BACKGROUND: Intranasal oxytocin (OT) has been shown to improve social communication functioning of individuals with autism spectrum disorder (ASD) and, thus, has received considerable interest as a potential ASD therapeutic agent. Although preclinical research indicates that OT modulates the functional output of the mesocorticolimbic dopamine system that processes rewards, no clinical brain imaging study to date has examined the effects of OT on this system using a reward processing paradigm...
March 27, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29580570/increased-alcohol-seeking-in-mice-lacking-gpr88-involves-dysfunctional-mesocorticolimbic-networks
#2
Sami Ben Hamida, Sueli Mendonça-Netto, Tanzil Mahmud Arefin, Md Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Toby Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Laura Adela Harsan, Rafael Maldonado, Brigitte Lina Kieffer
BACKGOUND: Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined. METHODS: We tested Gpr88 knockout mice for alcohol-drinking and -seeking behaviors. To gain system-level understanding of their alcohol endophenotype, we also analyzed whole-brain functional connectivity in naïve mice using resting-state functional magnetic resonance imaging...
February 9, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29551440/racing-the-clock-the-role-of-circadian-rhythmicity-in-addiction-across-the-lifespan
#3
REVIEW
Danielle Gulick, Joshua J Gamsby
Although potent effects of psychoactive drugs on circadian rhythms were first described over 30 years ago, research into the reciprocal relationship between the reward system and the circadian system - and the impact of this relationship on addiction - has only become a focus in the last decade. Nonetheless, great progress has been made in that short time toward understanding how drugs of abuse impact the molecular and physiological circadian clocks, as well as how disruption of normal circadian rhythm biology may contribute to addiction and ameliorate the efficacy of treatments for addiction...
March 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29535626/trace-amine-associated-receptor-1-taar1-modulation-of-food-reward
#4
REVIEW
Catherine F Moore, Valentina Sabino, Pietro Cottone
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use. Food intake is in part mediated by reward and reinforcement processes that can become dysregulated in these disorders. Additionally, impairments in inhibitory control regulation of reward-related responding can cause or further exacerbate binge and compulsive eating. Dysfunctions in two neurotransmitter systems in the mesocorticolimbic pathway, dopamine and glutamate, are thought to contribute to maladaptive eating behaviors...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29533964/prelimbic-cortex-deep-brain-stimulation-reduces-binge-size-in-a-chronic-binge-eating-rat-model
#5
Can Sarica, Mazhar Ozkan, Husniye Hacioglu Bay, Umit Sehirli, Filiz Onat, M Ibrahim Ziyal
BACKGROUND: Binge eating (BE) involves the consumption of a large amount of food in a short period of time and a loss of control during the binge episode. It is a key feature of the major subtypes of eating disorders like bulimia nervosa, BE disorder, anorexia nervosa binge/purge type. Alterations in the mesocorticolimbic pathway play a crucial role in its pathophysiology. OBJECTIVES: We hypothesized that BE rats receiving deep brain stimulation (DBS) in the prelimbic cortex, a functional analog of the dorsolateral prefrontal cortex in humans, would have a reduced binge size compared with those receiving sham stimulation...
March 13, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29530489/abnormal-ventral-tegmental-area-anterior-cingulate-cortex-connectivity-in-parkinson-s-disease-with-depression
#6
Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Chen
Neuropathology suggests that Parkinson's disease (PD) with depression may involve a progressive degeneration of the nigrostriatal and mesocorticolimbic dopaminergic systems. Previous positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies have shown that dopamine changes in individual brain regions constituting the nigrostriatal and mesocorticolimbic circuits are associated with depression in PD. However, few studies have been conducted on the circuit-level alterations in this disease...
March 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29503841/current-perspectives-on-incentive-salience-and-applications-to-clinical-disorders
#7
Jeffrey J Olney, Shelley M Warlow, Erin E Naffziger, Kent C Berridge
Affective neuroscience research has revealed that reward contains separable components of 'liking', 'wanting', and learning. Here we focus on current 'liking' and 'wanting' findings and applications to clinical disorders. 'Liking' is the hedonic impact derived from a pleasant experience, and is amplified by opioid and related signals in discrete sites located in limbic-related brain areas. 'Wanting' refers to incentive salience, a motivation process for reward, and is mediated by larger systems involving mesocorticolimbic dopamine...
August 2018: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29497369/reduced-orbitofrontal-gray-matter-concentration-as-a-marker-of-premorbid-childhood-trauma-in-cocaine-use-disorder
#8
Keren Bachi, Muhammad A Parvaz, Scott J Moeller, Gabriela Gan, Anna Zilverstand, Rita Z Goldstein, Nelly Alia-Klein
Background : Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as documented separately in addiction and for childhood trauma. The purpose of this study was to understand the contribution of childhood maltreatment to GMC effects in individuals with cocaine use disorder. Methods : Individuals with cocaine use disorder were partitioned into groups of low vs...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29485031/effects-of-extended-release-naltrexone-on-the-brain-response-to-drug-related-stimuli-in-patients-with-opioid-use-disorder
#9
Zhenhao Shi, An-Li Wang, Kanchana Jagannathan, Victoria P Fairchild, Charles P O'Brien, Anna Rose Childress, Daniel D Langleben
BACKGROUND: Heightened response to drug-related cues is a hallmark of addiction. Extended-release naltrexone (XR-NTX) is a US Food and Drug Administration-approved pharmacotherapy for relapse prevention in patients with opioid use disorder (OUD). In these patients, XR-NTX has been shown to reduce brain responses to opioid-related visual stimuli. To assess the biomarker potential of this phenomenon, it is necessary to determine whether this effect is limited to opioid-related stimuli and whether it is associated with key OUD symptoms...
February 23, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29483278/nigrostriatal-and-mesolimbic-d-2-3-receptor-expression-in-parkinson-s-disease-patients-with-compulsive-reward-driven-behaviors
#10
Adam J Stark, Christopher T Smith, Ya-Chen Lin, Kalen J Petersen, Paula Trujillo, Nelleke C van Wouwe, Hakmook Kang, Manus J Donahue, Robert M Kessler, David H Zald, Daniel O Claassen
The nigrostriatal and mesocorticolimbic dopamine networks regulate reward-driven behavior. Regional alterations to mesolimbic dopamine D2/3 receptor expression are described in drug-seeking and addiction disorders. Parkinson's disease (PD) patients are frequently prescribed D2 -like dopamine agonist (DAgonist) therapy for motor symptoms, yet a proportion develop clinically significant behavioral addictions characterized by impulsive and compulsive behaviors (ICBs). Until now, changes in D2/3 receptor binding in both striatal and extrastriatal regions have not been concurrently quantified in this population...
February 24, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29481626/developmental-lead-exposure-and-prenatal-stress-result-in-sex-specific-reprograming-of-adult-stress-physiology-and-epigenetic-profiles-in-brain
#11
Marissa Sobolewski, Garima Varma, Beth Adams, David W Anderson, Jay S Schneider, Deborah A Cory-Slechta
Developmental exposure to lead (Pb) and prenatal stress (PS) both impair cognition, which could derive from their joint targeting of the hypothalamic-pituitary-adrenal (HPA) axis and the brain mesocorticolimbic (MESO) system, including frontal cortex (FC) and hippocampus (HIPP). Glucocorticoids modulate both FC and HIPP function and associated mediation of cognitive and other behavioral functions. The present study sought to determine whether developmental Pb±PS exposures altered glucocorticoid-related epigenetic profiles in brain MESO regions in offspring of female mice exposed to 0 or 100 ppm Pb acetate drinking water from 2 mos prior to breeding until weaning, with half further exposed to prenatal restraint stress from gestational day 11-18...
February 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29470436/neurobiology-of-propofol-addiction-and-supportive-evidence-what-is-the-new-development
#12
REVIEW
Ming Xiong, Nimisha Shiwalkar, Kavya Reddy, Peter Shin, Alex Bekker
Propofol is a short-acting intravenous anesthetic agent suitable for induction and maintenance of general anesthesia as well as for procedural and intensive care unit sedation. As such it has become an unparalleled anesthetic agent of choice in many institutional and office practices. However, in addition to its idealistic properties as an anesthetic agent, there is accumulating evidence suggesting its potential for abuse. Clinical and experimental evidence has revealed that not only does propofol have the potential to be abused, but also that addiction to propofol shows a high mortality rate...
February 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29459754/cocaine-induced-locomotor-sensitization-associates-with-slow-oscillatory-firing-of-neurons-in-the-ventral-tegmental-area
#13
Chang-Liang Liu, Ya-Kun Wang, Guo-Zhang Jin, Wei-Xing Shi, Ming Gao
The initiation of psychostimulant sensitization depends on the mesocorticolimbic dopamine (DA) system. Although many cellular adaptations has been reported to be associated with this addictive behavior, the overall influence of these adaptations on the network regulation of DA neurons has not been established. Here, we profile a network-driven slow oscillation (SO) in the firing activity of ventral tegmental area (VTA) putative DA and non-DA neurons and their correlation with locomotor sensitization induced by repeated administration of cocaine...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29441714/time-dependent-regional-brain-distribution-of-methadone-and-naltrexone-in-the-treatment-of-opioid-addiction
#14
Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Hendrik G Kruger, Tricia Naicker, Nirmala D Gopal, Thavendran Govender
Opioid addiction is a serious public health concern with severe health and social implications; therefore, extensive therapeutic efforts are required to keep users drug free. The two main pharmacological interventions, in the treatment of addiction, involve management with methadone an mu (μ)-opioid agonist and treatment with naltrexone, μ-opioid, kappa (κ)-opioid and delta (δ)-opioid antagonist. MET and NAL are believed to help individuals to derive maximum benefit from treatment and undergo a full recovery...
February 14, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29438716/cholinergic-tone-in-ventral-tegmental-area-functional-organization-and-behavioral-implications
#15
REVIEW
Changzheng Zhang, Xiaodong Liu, Peiling Zhou, Junjie Zhang, Wuming He, Ti-Fei Yuan
The ventral tegmental area (VTA), a pivotal brain region of the mesocorticolimbic dopaminergic system, is substantially innervated and modulated by cholinergic projections from the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. In this review, we focus mainly on the current findings on VTA cholinergic compositions and functions, including VTA cholinergic innervations and synaptic connectivity, acetylcholine receptor expression and functional characteristics, cholinergic modulation of neuronal activity and dopamine efflux, cholinergic modulation of VTA-mediated behaviors such as reward and addiction, stress and depression, locomotion, etc...
February 10, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29380665/repeated-cocaine-exposure-dysregulates-bdnf-expression-and-signaling-in-the-mesocorticolimbic-pathway-of-the-adolescent-rat
#16
Lucia Caffino, Giuseppe Giannotti, Giulia Messa, Francesca Mottarlini, Fabio Fumagalli
OBJECTIVES: Long-term abstinence following cocaine exposure up-regulates brain-derived neurotrophic factor (BDNF) expression in the mesocorticolimbic pathway. Given the increased vulnerability to drug abuse typical of adolescence, we hypothesized that changes in BDNF expression may become manifest early after the end of cocaine treatment in the adolescent brain. METHODS: Rats received cocaine injections from postnatal day 28 (PND28) to PND42 and the mesocorticolimbic expression of BDNF was measured by real-time PCR and Western blotting at PND43...
February 21, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29377365/neonatal-exposure-to-estradiol-increases-dopaminergic-transmission-in-nucleus-accumbens-and-morphine-induced-conditioned-place-preference-in-adult-female-rats
#17
Christian Bonansco, Jonathan Martínez-Pinto, Roxana A Silva, Victoria B Velásquez, Andrés Martorell, Mónica V Selva, Pedro Espinosa, Pablo R Moya, Gonzalo Cruz, María Estela Andrés, Ramón Sotomayor-Zárate
Steroid sex hormones produce physiological effects in reproductive tissues and also in non-reproductive tissues such as the brain, particularly in cortical, limbic and midbrain areas. Dopamine (DA) neurons involved in processes such as prolactin secretion (tuberoinfundibular system), motor circuit regulation (nigrostriatal system) and driving of motivated behavior (mesocorticolimbic system), are specially regulated by sex hormones. Indeed, sex hormones promote neurochemical and behavioral effects induced by drugs of abuse by tuning midbrain DA neurons in adult animals...
January 29, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29340793/neuroimaging-findings-in-patients-with-medication-overuse-headache
#18
REVIEW
Tzu-Hsien Lai, Shuu-Jiun Wang
Medication overuse headache (MOH) is a secondary headache syndrome defined as the deterioration of the headache associated with the overuse of analgesics. The prevalence of MOH is 1-2% in the general population and even up to 50% in special clinics. Overuse of abortive medications is highly associated with chronic daily headaches and also a known risk factor for headache evolution. Possible mechanisms include neural plasticity changes such as sensitization and defective endogenous pain inhibition. Psychological studies have suggested dependence, even addiction, in patients with MOH...
January 16, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29325757/the-role-of-fatty-acids-and-their-endocannabinoid-like-derivatives-in-the-molecular-regulation-of-appetite
#19
REVIEW
Renger F Witkamp
Intake, absorption and synthesis of fatty acids, including those produced by the intestinal microbiota are tightly monitored via specific receptors and, indirectly through their conversion into a variety of signalling molecules. The resulting information is integrated and translated to different physiological processes, including the regulation of appetite and satiation. Direct chemosensing of fatty acids takes place via interaction with free fatty acid (FFA) and other receptors. These are present in the oronasal cavity and along the entire gastrointestinal tract, in various other tissues, and, for some receptors also in brain...
January 19, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29287910/ventral-tegmental-area-d2-receptor-knockdown-enhances-choice-impulsivity-in-a-delay-discounting-task-in-rats
#20
Kimberly A Bernosky-Smith, Yan-Yan Qiu, Malte Feja, Yun Beom Lee, Brian Loughlin, Jun-Xu Li, Caroline E Bass
Impulsivity associated with abnormal dopamine (DA) function has been observed in several disorders, including addiction. Choice impulsivity is the preference for small, immediate rewards over larger rewards after a delay, caused by excessive discounting of future rewards. Addicts have abnormally high discount rates and prefer the smaller rewards sooner. While impulsivity has been inversely correlated with DA D2 receptor (D2R) availability in the midbrain and striatum, it is difficult to mechanistically link the two, due to the diverse neuroanatomical localization of D2Rs, which are found throughout the brain, in many types of neurons and neuronal subcompartments...
April 2, 2018: Behavioural Brain Research
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