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https://www.readbyqxmd.com/read/29150451/elucidating-mechanisms-for-insect-body-size-partial-support-for-the-oxygen-dependent-induction-of-moulting-hypothesis
#1
Sami M Kivelä, Sonja Viinamäki, Netta Keret, Karl Gotthard, Esa Hohtola, Panu Välimäki
Body size is a key life history trait and knowledge of its mechanistic basis is crucial in life history biology. Such knowledge is accumulating in holometabolous insects, whose growth is characterised and body size affected by moulting. According to the oxygen-dependent induction of moulting (ODIM) hypothesis, moult is induced at a critical mass where oxygen demand of growing tissues overrides the supply that principally grows only at moults. Support for the ODIM hypothesis is controversial partly because of a lack of proper data to explicitly test the hypothesis...
November 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29149715/robust-brain-roi-segmentation-by-deformation-regression-and-deformable-shape-model
#2
Zhengwang Wu, Yanrong Guo, Sang Hyun Park, Yaozong Gao, Pei Dong, Seong-Whan Lee, Dinggang Shen
We propose a robust and efficient learning-based deformable model for segmenting regions of interest (ROIs) from structural MR brain images. Different from the conventional deformable-model-based methods that deform a shape model locally around the initialization location, we learn an image-based regressor to guide the deformable model to fit for the target ROI. Specifically, given any voxel in a new image, the image-based regressor can predict the displacement vector from this voxel towards the boundary of target ROI, which can be used to guide the deformable segmentation...
November 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29149582/corrigendum-the-science-and-practice-of-self-control
#3
(no author information available yet)
Original article: Duckworth, A. L., & Seligman, M. E. P. (2017). The science and practice of self-control. Perspectives on Psychological Science, 12, 715-718. doi:10.1177/1745691617690880 On p. 715, right column, first paragraph, Duckworth, Tsukayama, and May (2010) should have been cited instead of Emanuele et al. (2010). The reference list should not have included Emanuele et al. (2010). Instead, the following reference should have been included: Duckworth, A. L., Tsukayama, E., & May, H. (2010). Establishing causality using longitudinal hierarchical linear modeling: An illustration predicting achievement from self-control...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149556/evaluating-force-field-london-dispersion-coefficients-using-the-exchange-hole-dipole-moment-model
#4
Mohamad Mohebifar, Erin R Johnson, Christopher N Rowley
London dispersion interactions play an integral role in materials science and biophysics. Force fields for atomistic molecular simulations typically represent dispersion interactions by the 12-6 Lennard-Jones potential, using empirically-determined parameters. These parameters are generally underdetermined and there is no straightforward way to test if they are physically realistic. Alternatively, the exchange-hole dipole moment (XDM) model from density-functional theory predicts atomic and molecular London dispersion coefficients from first principles, providing an innovative strategy to validate the dispersion terms of molecular-mechanical force fields...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29149549/workflow-for-target-oriented-parametrization-of-an-enhanced-mechanistic-cell-culture-model
#5
Sophia Ulonska, Paul Kroll, Jens Fricke, Christoph Clemens, Raphael Voges, Markus Michael Müller, Christoph Herwig
The goal of this study was to develop a macroscopic mechanistic model describing growth and production within fed-batch cultivations of CHO cells. The model should be used for process characterization as well as for process monitoring including real-time parameter adaptations. The model proved to be able to describe a data-set of 40 processes differing in clones, scales and process conditions with a normalized root mean square error of approximately 10%. However, due to limited parameter identifiability and limited knowledge about physiologically meaningful parameter values, a broad range of parameters could describe the data with similar quality...
November 17, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29149069/temperature-uncertainty-analysis-of-injection-mechanism-based-on-kriging-modeling
#6
Dongdong You, Dehui Liu, Xiaomo Jiang, Xueyu Cheng, Xiang Wang
A kriging modeling method is proposed to conduct the temperature uncertainty analysis of an injection mechanism in squeeze casting. A mathematical model of temperature prediction with multi input and single output is employed to estimate the temperature spatiotemporal distributions of the injection mechanism. The kriging model applies different weights to the independent variables according to spatial location of sample points and their correlation, thus reducing the estimation variance. The predicted value of the kriging model is compared with the sample data at the corresponding position to investigate the influence of the temperature uncertainty of the injection mechanism on the injection process including friction...
November 17, 2017: Materials
https://www.readbyqxmd.com/read/29147791/completed-sequence-and-corrected-annotation-of-the-genome-of-maize-iranian-mosaic-virus
#7
Abozar Ghorbani, Keramatollah Izadpanah, Ralf G Dietzgen
Maize Iranian mosaic virus (MIMV) is a negative-sense single-stranded RNA virus that is classified in the genus Nucleorhabdovirus, family Rhabdoviridae. The MIMV genome contains six open reading frames (ORFs) that encode in 3΄ to 5΄ order the nucleocapsid protein (N), phosphoprotein (P), putative movement protein (P3), matrix protein (M), glycoprotein (G) and RNA-dependent RNA polymerase (L). In this study, we determined the first complete genome sequence of MIMV using Illumina RNA-Seq and 3'/5' RACE. MIMV genome ('Fars' isolate) is 12,426 nucleotides in length...
November 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29146719/can-arterial-spin-labeling-with-multiple-postlabeling-delays-predict-cerebrovascular-reserve
#8
H J Choi, C-H Sohn, S-H You, R-E Yoo, K M Kang, T J Yun, S H Choi, J-H Kim, W-S Cho, J E Kim
BACKGROUND AND PURPOSE: The effect of delayed transit time is the main source of error in the quantitative measurement of CBF in arterial spin-labeling. In the present study, we evaluated the usefulness of the transit time-corrected CBF and arterial transit time delay from multiple postlabeling delays arterial spin-labeling compared with basal/acetazolamide stress technetium Tc99m-hexamethylpropylene amineoxime (Tc99m-HMPAO) SPECT in predicting impairment in the cerebrovascular reserve...
November 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29146692/prediction-of-90-y-radioembolization-outcome-from-pre-therapeutic-factors-with-random-survival-forests
#9
Michael Ingrisch, Franziska Schöppe, Karolin Johanna Paprottka, Matthias Fabritius, Frederik F Strobl, Enrico de Toni, Harun Ilhan, Andrei Todica, Marlies Michl, Philipp Paprottka
To predict outcome of (90)Y radioembolization (RE) in patients with intrahepatic tumors from pre-therapeutic baseline parameters and to identify predictive variables using a machine-learning approach based on random survival forests (RSF). Materials and Methods: In this retrospective study, 366 patients with primary (n = 92) or secondary (n = 274) liver tumors who had received (90)Y radioembolization were analyzed. A random survival forest was trained to predict individual risk from baseline values of cholinesterase (CHE), bilirubin, type of primary tumor, age at radioembolization, hepatic tumor burden, presence of extrahepatic disease (EHD) and sex...
November 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29146340/effect-of-the-composition-of-extra-virgin-olive-oils-on-the-differentiation-and-antioxidant-capacities-of-twelve-monovarietals
#10
Edwar Fuentes, Fiorela Paucar, Francisco Tapia, Jaime Ortiz, Paula Jimenez, Nalda Romero
The effect of the composition of twelve varieties of extra virgin olive oils (EVOOs) on their differentiation based in agronomic criteria and on the antioxidant capacity was studied. Principal component analysis permitted an overview of the samples and their compositions, showing evidence of grouping and correlation between antioxidant capacity, oleuropein and ligstroside derivatives (OLD) and specific extinction at 270. Oleic and linoleic acids, 3,4-DHPEA-EA and p-HPEA-EDA (OLD), unsaturated/saturated ratio and induction time (IT) allowed the correct classification of samples according to year of harvest, ripening stage and variety...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146280/evolutionary-isolation-and-phylogenetic-diversity-loss-under-random-extinction-events
#11
Mike Steel, Vahab Pourfaraj, Abhishek Chaudhary, Arne Mooers
The extinction of species at the present leads to the loss of 'phylogenetic diversity' (PD) from the evolutionary tree in which these species lie. Prior to extinction, the total PD present can be divided up among the species in various ways using measures of evolutionary isolation (such as 'fair proportion' and 'equal splits'). However, the loss of PD when certain combinations of species become extinct can be either larger or smaller than the cumulative loss of the isolation values associated with the extinct species...
November 13, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29145933/quantitative-structure-pharmacokinetics-relationships-for-plasma-protein-binding-of-basic-drugs
#12
Zvetanka Dobreva Zhivkova
PURPOSE: Binding of drugs to plasma proteins is a common physiological occurrence which may have a profound effect on both pharmacokinetics and pharmacodynamics. The early prediction of plasma protein binding (PPB) of new drug candidates is an important step in drug development process. The present study is focused on the development of quantitative structure - pharmacokinetics relationship (QSPkR) for the negative logarithm of the free fraction of the drug in plasma (pfu) of basic drugs...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145931/in-vitro-and-in-silico-approaches-to-study-cytochrome-p450-mediated-interactions
#13
Boon Hooi Tan, Yan Pan, Amelia Nathania Dong, Chin Eng Ong
In vitro and in silico models of drug metabolism are utilized regularly in the drug research and development as tools for assessing pharmacokinetic variability and drug-drug interaction risk. The use of in vitro and in silico predictive approaches offers advantages including guiding rational design of clinical drug-drug interaction studies, minimization of human risk in the clinical trials, as well as cost and time savings due to lesser attrition during compound development process. This article gives a review of some of the current in vitro and in silico methods used to characterize cytochrome P450(CYP)-mediated drug metabolism for estimating pharmacokinetic variability and the magnitude of drug-drug interactions...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145521/characterization-of-rubella-specific-humoral-immunity-following-two-doses-of-mmr-vaccine-using-proteome-microarray-technology
#14
Iana H Haralambieva, Michael J Gibson, Richard B Kennedy, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland
INTRODUCTION//BACKGROUND: The lack of standardization of the currently used commercial anti-rubella IgG antibody assays leads to frequent misinterpretation of results for samples with low/equivocal antibody concentration. The use of alternative approaches in rubella serology could add new information leading to a fuller understanding of rubella protective immunity and neutralizing antibody response after vaccination. METHODS: We applied microarray technology to measure antibodies to all rubella virus proteins in 75 high and 75 low rubella virus-specific antibody responders after two MMR vaccine doses...
2017: PloS One
https://www.readbyqxmd.com/read/29145389/the-use-of-ambient-humidity-conditions-to-improve-influenza-forecast
#15
Jeffrey Shaman, Sasikiran Kandula, Wan Yang, Alicia Karspeck
Laboratory and epidemiological evidence indicate that ambient humidity modulates the survival and transmission of influenza. Here we explore whether the inclusion of humidity forcing in mathematical models describing influenza transmission improves the accuracy of forecasts generated with those models. We generate retrospective forecasts for 95 cities over 10 seasons in the United States and assess both forecast accuracy and error. Overall, we find that humidity forcing improves forecast performance (at 1-4 lead weeks, 3...
November 16, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29144422/atypical-processing-of-novel-distracters-in-a-visual-oddball-task-in-autism-spectrum-disorder
#16
Estate M Sokhadze, Eva V Lamina, Emily L Casanova, Desmond P Kelly, Ioan Opris, Irma Khachidze, Manuel F Casanova
Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a three-stimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task tested the hypothesis that children with autism are abnormally orienting attention to distracters probably due to impaired habituation to novelty. We predicted a lower selectivity in early ERPs to target, frequent non-target, and rare distracters...
November 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29144299/the-modelling-of-lead-removal-from-water-by-deep-eutectic-solvents-functionalized-cnts-artificial-neural-network-ann-approach
#17
Seef Saadi Fiyadh, Mohammed Abdulhakim AlSaadi, Mohamed Khalid AlOmar, Sabah Saadi Fayaed, Ako R Hama, Sharifah Bee, Ahmed El-Shafie
The main challenge in the lead removal simulation is the behaviour of non-linearity relationships between the process parameters. The conventional modelling technique usually deals with this problem by a linear method. The substitute modelling technique is an artificial neural network (ANN) system, and it is selected to reflect the non-linearity in the interaction among the variables in the function. Herein, synthesized deep eutectic solvents were used as a functionalized agent with carbon nanotubes as adsorbents of Pb(2+)...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29143712/accuracy-and-bias-of-genomic-prediction-with-different-de-regression-methods
#18
H Song, L Li, Q Zhang, S Zhang, X Ding
Genomic selection has become increasingly important in the breeding of animals and plants. The response variable is an important factor, influencing the accuracy of genomic selection. The de-regressed proof (DRP) based on traditional estimated breeding value (EBV) is commonly used as response variable. In the current study, simulated data from 16th QTL-MAS Workshop and real data from Chinese Holstein cattle were used to compare accuracy and bias of genomic prediction with two methods of calculating DRP. Our results with simulated data showed that the correlation between genomic EBV and true breeding value achieved using the Jairath method (DRP_J) was superior to that achieved using the Garrick method (DRP_G) for simulated trait 1 but the reverse was true for simulated trait 3, and these two methods performed comparably for simulated trait 2...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29143639/linking-household-surveys-and-health-facility-assessments-to-estimate-intervention-coverage-for-the-lives-saved-tool-list
#19
Mufaro Kanyangarara, Victoria B Chou
BACKGROUND: Calls have been made for improved measurement of coverage for maternal, newborn and child health interventions. Recently, methods linking household and health facility surveys have been used to improve estimation of intervention coverage. However, linking methods rely the availability of household and health facility surveys which are temporally matched. Because nationally representative health facility assessments are not yet routinely conducted in many low and middle income countries, estimates of intervention coverage based on linking methods can be produced for only a subset of countries...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29143393/an-algorithm-to-detect-unexpected-increases-in-frequency-of-reports-of-adverse-events-in-eudravigilance
#20
Luis C Pinheiro, Gianmario Candore, Cosimo Zaccaria, Jim Slattery, Peter Arlett
PURPOSE: The European Medicines Agency developed an algorithm to detect unexpected increases in frequency of reports, to enhance the ability to detect adverse events that manifest as increases in frequency, in particular quality defects, medication errors, and cases of abuse or misuse. METHODS: An algorithm based on a negative binomial time-series regression model run on 6 sequential observations prior to the monitored period was developed to forecast monthly counts of reports...
November 16, 2017: Pharmacoepidemiology and Drug Safety
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