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https://www.readbyqxmd.com/read/29793213/end-stage-renal-disease-models-in-the-americas-optimizing-resources-to-achieve-better-health-outcomes
#1
Ramiro E Gilardino, Eduardo González-Pier, Claudia Brabata
End-stage renal disease, the last and most severe stage of chronic kidney disease, represents a major and rising concern for countries in Latin America, driven in large part by aging populations and the near-epidemic rises in diabetes, obesity, and hypertension. This places a great clinical, economic, and social burden on the region's health systems. During the ISPOR 6th Latin America Conference held in Sao Paulo, Brazil, in September 2017, an educational forum debated on value-based decision making in the treatment of end-stage renal disease in Latin America...
May 21, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29793175/apolipoprotein-ciii-and-n-terminal-prohormone-b-type-natriuretic-peptide-as-independent-predictors-for-cardiovascular-disease-in-type-2-diabetes
#2
Marco Colombo, Helen C Looker, Bassam Farran, Felix Agakov, M Julia Brosnan, Paul Welsh, Naveed Sattar, Shona Livingstone, Paul N Durrington, D John Betteridge, Paul M McKeigue, Helen M Colhoun
BACKGROUND AND AIMS: Developing sparse panels of biomarkers for cardiovascular disease in type 2 diabetes would enable risk stratification for clinical decision making and selection into clinical trials. We examined the individual and joint performance of five candidate biomarkers for incident cardiovascular disease (CVD) in type 2 diabetes that an earlier discovery study had yielded. METHODS: Apolipoprotein CIII (apoCIII), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), high sensitivity Troponin T (hsTnT), Interleukin-6, and Interleukin-15 were measured in baseline serum samples from the Collaborative Atorvastatin Diabetes trial (CARDS) of atorvastatin versus placebo...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29792972/association-between-early-confirmatory-testing-and-the-adoption-of-active-surveillance-for-men-with-favorable-risk-prostate-cancer
#3
Deborah R Kaye, Ji Qi, Todd M Morgan, Susan Linsell, Brian R Lane, James E Montie, Michael L Cher, David C Miller
OBJECTIVE: To examine the relationship between the use and results of early confirmatory testing and persistence on active surveillance (AS). METHODS: We identified all men in the MUSIC registry diagnosed with favorable-risk prostate cancer from 01/2016-02/2017. We next examined trends in the use of early confirmatory test(s), defined as repeat biopsy, prostate MRI and/or molecular classifiers obtained within 6-months of the initial cancer diagnosis, in patients with favorable-risk prostate cancer...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792774/when-the-good-looks-bad-an-experimental-exploration-of-the-repulsion-effect
#4
Mikhail S Spektor, David Kellen, Jared M Hotaling
When people are choosing among different options, context seems to play a vital role. For instance, adding a third option can increase the probability of choosing a similar dominating option. This attraction effect is one of the most widely studied phenomena in decision-making research. Its prevalence, however, has been challenged recently by the tainting hypothesis, according to which the inferior option contaminates the attribute space in which it is located, leading to a repulsion effect. In an attempt to test the tainting hypothesis and explore the conditions under which dominated options make dominating options look bad, we conducted four preregistered perceptual decision-making studies with a total of 301 participants...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29792726/i-like-them%C3%A2-will-they-like-me-evidence-for-the-role-of-the-ventrolateral-prefrontal-cortex-during-mismatched-social-appraisals-in-anxious-youth
#5
Ashley R Smith, Eric E Nelson, Brent I Rappaport, Daniel S Pine, Ellen Leibenluft, Johanna M Jarcho
OBJECTIVE: Socially anxious adolescents report distress during social decision-making, wherein their favorable view of peers directly conflicts with their expectation to be viewed negatively by peers; a phenomenon we refer to as "mismatch bias." The present study utilizes a novel paradigm with dynamic social stimuli to explore the correlates of mismatch biases in anxious and healthy youth. METHOD: The behavioral and neural correlates of mismatch biases were assessed in healthy (N = 17) and anxious (N = 14) youth during functional MRI...
May 24, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29792649/network-meta-analysis-a-new-statistical-technique-at-urologists-disposal-to-improve-decision-making
#6
EDITORIAL
Herney Andres Garcia-Perdomo
No abstract text is available yet for this article.
May 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29792462/extreme-teams-toward-a-greater-understanding-of-multiagency-teamwork-during-major-emergencies-and-disasters
#7
Nicola Power
Major emergencies are extreme team decision making environments. They are complex, dynamic, high-stakes and fast paced events, wherein successful resolution is contingent upon effective teamwork. Not only do emergency teams coordinate at the intrateam level (e.g., police team), but they are increasingly required to operate at the interteam level (e.g., police, fire and ambulance teams). This is in response to the desire for networked and cost-effective practice and due to the evolving nature of modern threats, such as extreme weather events and terrorist attacks, which require a multi- rather than single-agency response...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792461/teamwork-in-the-intensive-care-unit
#8
Jennifer N Ervin, Jeremy M Kahn, Taya R Cohen, Laurie R Weingart
Intensive care units (ICUs) provide care to the most severely ill hospitalized patients. Although ICUs increasingly rely on interprofessional teams to provide critical care, little about actual teamwork in this context is well understood. The ICU team is typically comprised of physicians or intensivists, clinical pharmacists, respiratory therapists, dieticians, bedside nurses, clinical psychologists, and clinicians-in-training. ICU teams are distinguished from other health care teams in that they are low in temporal stability, which can impede important team dynamics...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792296/-it-s-totally-okay-to-be-sad-but-never-lose-hope-content-analysis-of-infertility-related-videos-on-youtube-in-relation-to-viewer-preferences
#9
Margot Kelly-Hedrick, Paul H Grunberg, Felicia Brochu, Phyllis Zelkowitz
BACKGROUND: Infertility patients frequently use the internet to find fertility-related information and support from people in similar circumstances. YouTube is increasingly used as a source of health-related information and may influence health decision making. There have been no studies examining the content of infertility-related videos on YouTube. OBJECTIVE: The purpose of this study was to (1) describe the content of highly viewed videos on YouTube related to infertility and (2) identify video characteristics that relate to viewer preference...
May 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29792279/can-intraoperative-measurement-of-bone-quality-help-in-decision-making-for-cementless-unicompartmental-knee-arthroplasty
#10
Johannes A Eckert, Sebastian Jaeger, Matthias C Klotz, Martin Schwarze, Rudi G Bitsch
BACKGROUND: In uncemented total hip arthroplasty (THA), low bone mineral density (BMD) is associated with aseptic loosening. BMD is usually assessed via dual-energy X-ray absorptiometry (DXA) or quantitative computed tomography, which takes time and exposes patients to radiation. Due to its low risk profile, intraoperative measurement of the trabecular stability might be a useful alternative to DXA. METHODS: In 24 human femora, BMD was analysed using DXA at the femoral necks and the knees...
May 20, 2018: Knee
https://www.readbyqxmd.com/read/29792211/the-impact-of-ankle-foot-orthoses-on-toe-clearance-strategy-in-hemiparetic-gait-a-cross-sectional-study
#11
Kannit Pongpipatpaiboon, Masahiko Mukaino, Fumihiro Matsuda, Kei Ohtsuka, Hiroki Tanikawa, Junya Yamada, Kazuhiro Tsuchiyama, Eiichi Saitoh
BACKGROUND: Ankle-foot orthoses (AFOs) are frequently used to improve gait stability, toe clearance, and gait efficiency in individuals with hemiparesis. During the swing phase, AFOs enhance lower limb advancement by facilitating the improvement of toe clearance and the reduction of compensatory movements. Clinical monitoring via kinematic analysis would further clarify the changes in biomechanical factors that lead to the beneficial effects of AFOs. The purpose of this study was to investigate the actual impact of AFOs on toe clearance, and determine the best strategy to achieve toe clearance (including compensatory movements) during the swing phase...
May 23, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29792117/the-rockwood-classification-in-acute-acromioclavicular-joint-injury-does-not-correlate-with-symptoms
#12
J Granville-Chapman, E Torrance, A Rashid, L Funk
PURPOSE: Rockwood classified acromioclavicular (AC) joint injuries by displacement of the joint on radiographs. This classification has driven the management dogma of acute AC dislocation. The correlation between Rockwood grade and symptoms has not been described in acute injury. This study assesses that relationship. METHODS: This series included 77 patients with acute AC joint injury (<6 weeks), treated between 2006 and 2015. Objective and patient-reported measures enabled correlation between clinical measures and Rockwood grade...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29792060/warfarin-monitoring-with-viscoelastic-haemostatic-assays-thrombin-generation-coagulation-factors-and-correlations-to-owren-and-quick-prothrombin-time
#13
Caroline U Nilsson, Karin Strandberg, Peter Reinstrup
The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. However, many patients are still anticoagulated with warfarin and effect of warfarin anticoagulation on VHA is uncertain. The aim of this study was to assess warfarin anticoagulation on three different VHA and compare these findings with prothrombin time (PT), coagulation factor analyses and a thrombin generation assay (TGA)...
May 23, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29792018/predictive-factors-of-a-poor-outcome-following-revascularization-for-critical-limb-ischemia-implications-for-practice
#14
Mireia Martínez, Claudia Sosa, Alina Velescu, Carme Llort, Roberto Elosua, Albert Clarà
BACKGROUND/OBJECTIVE: Advancements in open and endovascular techniques have brought a widespread indication of revascularization in the majority of patients with critical limb ischemia (CLI). However, some cases still have a dismal short-term outcome. Identifying preoperative variables that characterize these patients could be important to prevent futile decisions. The aim of this study was to define predictive risk factors of mortality and/or major amputation after revascularization for CLI...
May 23, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29791777/counting-on-death-quantitative-aspects-of-bcl-2-family-regulation
#15
REVIEW
Annika Hantusch, Markus Rehm, Thomas Brunner
The Bcl-2 protein family members critically regulate mitochondrial outer membrane permeabilization (MOMP), a point-of-no-return in the intrinsic and extrinsic apoptosis pathways. The common view on qualitative interaction and activation patterns of the three subclasses, the BH3-only proteins, prosurvivals and effectors, is static and currently being revolutionized by an emerging understanding of the complex dynamic equilibria that govern cellular fate. Recent experimental evidence on protein associations with the mitochondrial outer membrane, retrotranslocation to the cytosol and differential binding affinities in aqueous and membranous environments instigate the development of a revised model of Bcl-2 family interplay...
May 23, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29791762/ethical-dilemmas-in-nursing-an-integrative-review
#16
REVIEW
Jennifer Rainer, Joanne Kraenzle Schneider, Rebecca A Lorenz
AIMS: The purpose of this integrative review was to identify themes and gaps in the literature to stimulate researchers to develop strategies to guide decision-making among clinical nurses faced with ethical dilemmas. BACKGROUND: The concept of ethical dilemmas has been well explored in nursing because of the frequency of ethical dilemmas in practice and the toll these dilemmas can take on nurses. Although ethical dilemmas are prevalent in nursing practice, frequently leading to moral distress, there is little guidance in the literature to help nurses resolve them...
May 23, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29791717/termination-of-pregnancy-following-a-prenatal-diagnosis-of-down-syndrome-a-qualitative-study-of-the-decision-making-process-of-pregnant-couples
#17
Stina Lou, Kathrine Carstensen, Olav Bjørn Petersen, Camilla Palmhøj Nielsen, Lone Hvidman, Maja Retpen Lanther, Ida Vogel
In Denmark, first trimester screening has a very high uptake (>90%). If Down syndrome is diagnosed, termination rates are high (>95%). The aim of this study was to investigate the timing of the decision of termination of pregnancy following a Down syndrome diagnosis and the factors influencing this decision MATERIAL AND METHODS: Semi-structured, qualitative interview study with 21 couples who had received a prenatal diagnosis of Down syndrome and decided to terminate the pregnancy. Participants were recruited from obstetric departments between February 2016 and July 2017...
May 23, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29791286/metastatic-pancreatic-cancer-asco-clinical-practice-guideline-update
#18
Davendra P S Sohal, Erin B Kennedy, Alok Khorana, Mehmet S Copur, Christopher H Crane, Ignacio Garrido-Laguna, Smitha Krishnamurthi, Cassadie Moravek, Eileen M O'Reilly, Philip A Philip, Ramesh K Ramanathan, Joseph T Ruggiero, Manish A Shah, Susan Urba, Hope E Uronis, Michelle W Lau, Daniel Laheru
Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis, first- and second-line treatment options, palliative and supportive care, and follow-up. The purpose of this update is to incorporate new evidence related to second-line therapy for patients who have experienced disease progression or intolerable toxicity during first-line therapy. Methods ASCO convened an Expert Panel to conduct a systematic review of the literature on second-line therapy published between June 2015 and January 2018...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29791243/amcp-partnership-forum-managing-care-in-the-wave-of-precision-medicine
#19
(no author information available yet)
Precision medicine, the customization of health care to an individual's genetic profile while accounting for biomarkers and lifestyle, has increasingly been adopted by health care stakeholders to guide the development of treatment options, improve treatment decision making, provide more patient-centered care, and better inform coverage and reimbursement decisions. Despite these benefits, key challenges prevent its broader use and adoption. On December 7-8, 2017, the Academy of Managed Care Pharmacy convened a group of stakeholders to discuss these challenges and provide recommendations to facilitate broader adoption and use of precision medicine across health care settings...
May 23, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29790982/peritumoral-edema-relative-to-meningioma-size-predicts-functional-outcomes-after-resection-in-older-patients
#20
Joshua Loewenstern, Amit Aggarwal, Margaret Pain, Ernest Barthélemy, Anthony Costa, Joshua Bederson, Raj K Shrivastava
BACKGROUND: Resection of meningiomas in older adults is associated with increased complications and postoperative functional deficits. Extent of peritumoral edema (PTE), which has been associated with surgical prognosis, may represent a preoperative risk marker for poorer outcomes in older adults. OBJECTIVE: To quantitatively evaluate the relationship between preoperative PTE and postresection outcomes in older meningioma patients. METHODS: One hundred twelve older meningioma patients (age ≥ 60) with evidence of PTE on MRI were reviewed...
May 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
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