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https://www.readbyqxmd.com/read/28454040/the-role-of-dissimilatory-arsenate-reducing-bacteria-in-the-biogeochemical-cycle-of-arsenic-based-on-the-physiological-and-functional-analysis-of-aeromonas-sp-o23a
#1
Witold Uhrynowski, Klaudia Debiec, Aleksandra Sklodowska, Lukasz Drewniak
Dissimilatory arsenate reducing bacteria (DARB) are known to contribute to the mobilization of arsenic and other elements from minerals. Despite this, metabolic capabilities of only a few DARB strains have been thoroughly investigated so far, and the influence of these bacteria on the bioavailability of arsenic in the environment is still a topic for discussion. In this study, Aeromonas sp. O23A, one of the dominant DARB strains found in the Zloty Stok mine (SW Poland), was subjected to a detailed physiological and functional analysis aimed to identify the actual environmental impact of this strain...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453966/psychotherapy-for-depression-among-advanced-incurable-cancer-patients-a-systematic-review-and-meta-analysis
#2
REVIEW
Toru Okuyama, Tatsuo Akechi, Lisa Mackenzie, Toshi A Furukawa
BACKGROUND: There is a high prevalence of depressive disorder and depressive symptoms among advanced, incurable cancer patients. Patients commonly report a preference for non-pharmacological treatments such as psychotherapy over pharmacological treatments for depression. The objective of this review was to investigate the effectiveness of psychotherapy for the treatment of depression in people with advanced, incurable cancer via a meta-analysis of randomized controlled trials (RCTs). METHODS: We searched research databases and clinical trial registries for studies published prior to June 2015...
April 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28453437/umbilical-cord-as-human-cell-source-for-mitral-valve-tissue-engineering-venous-vs-arterial-cells
#3
Axel Malischewski, Ricardo Moreira, Luis Hurtado, Valentine Gesché, Thomas Schmitz-Rode, Stefan Jockenhoevel, Petra Mela
Around 2% of the population in developed nations are affected by mitral valve disease and available valvular replacements are not designed for the atrioventricular position. Recently our group developed the first tissue-engineered heart valve (TEHV) specifically designed for the mitral position - the TexMi valve. The valve recapitulates the main components of the native valve, i.e. annulus, asymmetric leaflets and the crucial chordae tendineae. In the present study, we evaluated the human umbilical cord as a clinically applicable cell source for the TexMi valve...
April 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28449268/ventral-but-not-dorsal-hippocampus-inactivation-impairs-reward-memory-expression-and-retrieval-in-contexts-defined-by-proximal-cues
#4
Sadia Riaz, Anett Schumacher, Seyon Sivagurunathan, Matthijs Van Der Meer, Rutsuko Ito
The hippocampus (HPC) has been widely implicated in the contextual control of appetitive and aversive conditioning. However, whole hippocampal lesions do not invariably impair all forms of contextual processing, as in the case of complex biconditional context discrimination, leading to contention over the exact nature of the contribution of the HPC in contextual processing. Moreover, the increasingly well-established functional dissociation between the dorsal (dHPC) and ventral (vHPC) subregions of the HPC has been largely overlooked in the existing literature on hippocampal-based contextual memory processing in appetitively-motivated tasks...
April 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28449073/genetics-of-phenotypic-plasticity-and-biomass-traits-in-hybrid-willows-across-contrasting-environments-and-years
#5
Sofia Berlin, Henrik R Hallingbäck, Friderike Beyer, Nils-Erik Nordh, Martin Weih, Ann-Christin Rönnberg-Wästljung
Background and Aims: Phenotypic plasticity can affect the geographical distribution of taxa and greatly impact the productivity of crops across contrasting and variable environments. The main objectives of this study were to identify genotype-phenotype associations in key biomass and phenology traits and the strength of phenotypic plasticity of these traits in a short-rotation coppice willow population across multiple years and contrasting environments to facilitate marker-assisted selection for these traits...
April 25, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28448025/novel-assay-for-cold-nociception-in-drosophila-larvae
#6
Heather N Turner, Christian Landry, Michael J Galko
How organisms sense and respond to noxious temperatures is still poorly understood. Further, the mechanisms underlying sensitization of the sensory machinery, such as in patients experiencing peripheral neuropathy or injury-induced sensitization, are not well characterized. The genetically tractable Drosophila model has been used to study the cells and genes required for noxious heat detection, which has yielded multiple conserved genes of interest. Little is known however about the cells and receptors important for noxious cold sensing...
April 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447482/quantitative-potassium-measurements-with-laser-induced-breakdown-spectroscopy-using-low-energy-lasers-application-to-in-situ-k-ar-geochronology-for-planetary-exploration
#7
Yuichiro Cho, Misa Horiuchi, Kazuo Shibasaki, Shingo Kameda, Seiji Sugita
In situ radiogenic isotope measurements to obtain the absolute age of geologic events on planets are of great scientific value. In particular, K-Ar isochrons are useful because of their relatively high technical readiness and high accuracy. Because this isochron method involves spot-by-spot K measurements using laser-induced breakdown spectroscopy (LIBS) and simultaneous Ar measurements with mass spectrometry, LIBS measurements are conducted under a high vacuum condition in which emission intensity decreases significantly...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28447289/electroencephalographic-evidence-of-abnormal-anticipatory-uncertainty-processing-in-gambling-disorder-patients
#8
Alberto Megías, Juan F Navas, Ana Perandrés-Gómez, Antonio Maldonado, Andrés Catena, José C Perales
Putting money at stake produces anticipatory uncertainty, a process that has been linked to key features of gambling. Here we examined how learning and individual differences modulate the stimulus preceding negativity (SPN, an electroencephalographic signature of perceived uncertainty of valued outcomes) in gambling disorder patients (GDPs) and healthy controls (HCs), during a non-gambling contingency learning task. Twenty-four GDPs and 26 HCs performed a causal learning task under conditions of high and medium uncertainty (HU, MU; null and positive cue-outcome contingency, respectively)...
April 26, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28447242/testing-the-online-reading-effects-of-emotionality-on-relative-clause-attachment
#9
Javier García-Orza, José Manuel Gavilán, Isabel Fraga, Pilar Ferré
Previous research has shown the impact of the emotional dimension of nouns (i.e., valence and arousal) on the completion of relative clauses (RC) that are preceded by a double antecedent [e.g.,: Someone shot the servant (the first noun phrase, NP1) of the actress (the second noun phrase, NP2) who was on the balcony] (Fraga et al. in Q J Exp Psychol 65:1740-1759, 2012). The present study explored for the first time the role of emotional valence, specifically emotional positive nouns, on RC disambiguation in a self-paced reading experiment...
April 26, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28447234/remediation-of-soils-contaminated-with-heavy-metals-with-an-emphasis-on-immobilization-technology
#10
REVIEW
Zahra Derakhshan Nejad, Myung Chae Jung, Ki-Hyun Kim
The major frequent contaminants in soil are heavy metals which may be responsible for detrimental health effects. The remediation of heavy metals in contaminated soils is considered as one of the most complicated tasks. Among different technologies, in situ immobilization of metals has received a great deal of attention and turned out to be a promising solution for soil remediation. In this review, remediation methods for removal of heavy metals in soil are explored with an emphasis on the in situ immobilization technique of metal(loid)s...
April 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28446883/in-vitro-and-in-vivo-profile-of-ppl-101-and-ppl-103-mixed-opioid-partial-agonist-analgesics-with-low-abuse-potential
#11
Taline V Khroyan, Andrea Cippitelli, Nicholas Toll, John A Lawson, William Crossman, Willma E Polgar, Lawrence Toll
Opiates are still the most effective and widely used treatments for acute and chronic pain. However, the problems associated with morphine and other standard opioid analgesics severely limit their effectiveness in the clinic. PPL-101 and PPL-103 derived from morphine and morphinan ring systems contain a chiral N-substituent, which confers it with a unique combination of high-binding affinities and partial agonist activities at mu, delta, and kappa opioid receptors, leading to unique in vivo pharmacology compared to other conventional opioids...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28446527/the-value-of-different-aspects-of-person-centred-care-a-series-of-discrete-choice-experiments-in-people-with-long-term-conditions
#12
Christopher D Burton, Vikki A Entwistle, Alison M Elliott, Nicolas Krucien, Terry Porteous, Mandy Ryan
OBJECTIVE: To measure the value the patients place on different aspects of person-centred care. DESIGN: We systematically identified four attributes of person-centred care. We then measured their value to 923 people with either chronic pain or chronic lung disease over three discrete choice experiments (DCEs) about services to support self-management. We calculated the value of each attribute for all respondents and identified groups of people with similar preferences using latent class modelling...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446212/doctors-preferences-in-de-escalating-dmards-in-rheumatoid-arthritis-a-discrete-choice-experiment
#13
T Martijn Kuijper, Riëtte Folmer, Elly A Stolk, Johanna M W Hazes, Jolanda J Luime
BACKGROUND: Current guidelines suggest reduction of DMARDs can be considered in RA patients in remission. Objectives were (1) to estimate the relative importance of patient characteristics rheumatologists consider in their decision to de-escalate (2) to assess whether heterogeneity exists among rheumatologists with respect to de-escalation and (3) to identify the preferred de-escalation strategy. METHODS: A discrete choice experiment (DCE) was conducted. All rheumatologists and trainees in The Netherlands were invited to participate...
April 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28443675/the-effect-of-trigger-finger-injection-site-on-injection-related-pain
#14
Yoseph A Rosenbaum, Nikki Benvenuti, Jingzhen Yang, Michael E Ruff, Hisham M Awan, Julie Balch Samora
BACKGROUND: Stenosing tenosynovitis, or trigger digit, is a common condition for which patients often seek relief. Corticosteroid injections have been shown to provide relief in many cases, and several different approaches for delivering the injection have been described in the literature. We compared patients' perception of pain following each of 3 accepted injection methods, namely, palmar proximal, palmar distal, and webspace approaches. METHODS: We prospectively followed 38 patients with 39 symptomatic digits in this trial, with varying severities of trigger finger as graded by the Patel and Moradia classification...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28442911/are-psychiatric-comorbidities-and-associated-cognitive-functions-related-to-treatment-response-to-methylphenidate-in-boys-with-attention-deficit-hyperactivity-disorder
#15
Mandy H Chan, Patrick Wl Leung, Ting-Pong Ho, Se-Fong Hung, Chi-Chiu Lee, Chun-Pan Tang, Ka-Chai Cheung, Fung-Yee Ching, Fefe Hk Chan, Lu-Hua Chen, Merce Garcia-Barcelo, Pak-Chung Sham
BACKGROUND: Methylphenidate (MPH) has been found to be an effective medication for attention-deficit/hyperactivity disorder (ADHD). However, there are neither consistent nor sufficient findings on whether psychiatric comorbidities and associated cognitive functions of ADHD are related to treatment response to MPH in ADHD children. OBJECTIVES: This study investigated whether psychiatric comorbidities, IQ, and neurocognitive deficits are related to treatment response to MPH in ADHD children...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28442386/arginine-deiminase-pathway-provides-atp-and-boosts-growth-of-the-gas-fermenting-acetogen-clostridium-autoethanogenum
#16
Kaspar Valgepea, Kim Q Loi, James B Behrendorff, Renato de S P Lemgruber, Manuel Plan, Mark P Hodson, Michael Köpke, Lars K Nielsen, Esteban Marcellin
Acetogens are attractive organisms for the production of chemicals and fuels from inexpensive and non-food feedstocks such as syngas (CO, CO2 and H2). Expanding their product spectrum beyond native compounds is dictated by energetics, particularly ATP availability. Acetogens have evolved sophisticated strategies to conserve energy from reduction potential differences between major redox couples, however, this coupling is sensitive to small changes in thermodynamic equilibria. To accelerate the development of strains for energy-intensive products from gases, we used a genome-scale metabolic model (GEM) to explore alternative ATP-generating pathways in the gas-fermenting acetogen Clostridium autoethanogenum...
April 22, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28442231/case-control-vaccine-effectiveness-studies-preparation-design-and-enrollment-of-cases-and-controls
#17
REVIEW
Jennifer R Verani, Abdullah H Baqui, Claire V Broome, Thomas Cherian, Cheryl Cohen, Jennifer L Farrar, Daniel R Feikin, Michelle J Groome, Rana A Hajjeh, Hope L Johnson, Shabir A Madhi, Kim Mulholland, Katherine L O'Brien, Umesh D Parashar, Manish M Patel, Laura C Rodrigues, Mathuram Santosham, J Anthony Scott, Peter G Smith, Halvor Sommerfelt, Jacqueline E Tate, J Chris Victor, Cynthia G Whitney, Anita K Zaidi, Elizabeth R Zell
Case-control studies are commonly used to evaluate effectiveness of licensed vaccines after deployment in public health programs. Such studies can provide policy-relevant data on vaccine performance under 'real world' conditions, contributing to the evidence base to support and sustain introduction of new vaccines. However, case-control studies do not measure the impact of vaccine introduction on disease at a population level, and are subject to bias and confounding, which may lead to inaccurate results that can misinform policy decisions...
April 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28441597/differences-in-nitrate-and-phosphorus-export-between-wooded-and-grassed-riparian-zones-from-farmland-to-receiving-waterways-under-varying-rainfall-conditions
#18
Amanda D Neilen, Chengrong R Chen, Brett M Parker, Stephen J Faggotter, Michele A Burford
Agricultural activities in catchments can cause excessive nutrient loads in waterways. Catchment nitrogen (N) and phosphorus (P) flows may be intercepted and assimilated by riparian vegetation. While prior studies suggest that woody vegetation is preferable for reducing P loads, the question remains: is woody vegetation or grass cover more effective at reducing catchment N and P exports to waterways. To address this we investigated the relative importance of vegetation type, hydrologic and soil microbial processes on N and P losses from soil to a stream...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28439295/production-of-high-concentration-n-caproic-acid-from-lactate-through-fermentation-using-a-newly-isolated-ruminococcaceae-bacterium-cpb6
#19
Xiaoyu Zhu, Yan Zhou, Yi Wang, Tingting Wu, Xiangzhen Li, Daping Li, Yong Tao
BACKGROUND: n-Caproic acid (CA), as a medium-chain carboxylic acid, is a valuable chemical feedstock for various industrial applications. The fermentative production of CA from renewable carbon sources has attracted a lot of attentions. Lactate is a significant intermediate waste in the anaerobic breakdown of carbohydrates that comprise 18-70% of the chemical oxygen demand (COD) in municipal and some industrial wastewaters. Recently, researchers (including our own group) reported the CA production using lactate as electron donor with newly identified microbiome systems...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28439098/uncoupling-dapk1-from-nmda-receptor-glun2b-subunit-exerts-rapid-antidepressant-like-effects
#20
S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi, L Lu
Several preclinical studies have reported the rapid antidepressant effects of N-methyl-D-aspartate receptor (NMDAR) antagonists, although the underlying mechanisms are still unclear. Death-associated protein kinase 1 (DAPK1) couples GluN2B subunits at extrasynaptic sites to regulate NMDAR channel conductance. In the present study, we found that chronic unpredictable stress (CUS) induced extracellular glutamate accumulation, accompanied by an increase in the DAPK1-NMDAR interaction, the high expression of DAPK1 and phosphorylated GluN2B at Ser1303, a decrease in phosphorylated DAPK1 at Ser308 and synaptic protein deficits in the rat medial prefrontal cortex (mPFC)...
April 25, 2017: Molecular Psychiatry
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